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Pacemaker programming

Masao Takahashi, Nicolas Badenco, Jacques Monteau, Estelle Gandjbakhch, Fabrice Extramiana, Marina Urena, Nicole Karam, Eloi Marijon, Vincent Algalarrondo, Emmanuel Teiger, Nicolas Lellouche
OBJECTIVES: This study aimed to assess the impact of pacemaker mode programming on clinical outcomes in patients with high-degree atrioventricular conduction disturbance (AVCD) after transcatheter aortic valve implantation (TAVI). BACKGROUND: Although high-degree AVCD after TAVI can receive pacemaker, recovery of the AVCD is often observed. Specific pacemaker algorithms (AAI-DDD mode switch) are available which favor spontaneous atrioventricular conduction. METHODS: Of 1,621 consecutive multi-center TAVI patients, 269 (16...
March 14, 2018: Catheterization and Cardiovascular Interventions
Frank Edelmann, Christoph Knosalla, Klaus Mörike, Christiane Muth, Peggy Prien, Stefan Störk
BACKGROUND: Chronic heart failure (CHF) is the most common reason for hospital admissions in Germany. For the National Disease Management Guideline (NDMG) on CHF, a multidisciplinary expert panel revised the chapters on drug therapy, invasive therapy, and care coordination, following the methods of evidence-based medicine. METHODS: Recommendations are based on international guideline adaptations or systematic literature search. They were developed by a multidisciplinary expert panel, approved in a formal consensus procedure, and tested in open consultation, as specified by the requirements for S3 guidelines...
February 23, 2018: Deutsches Ärzteblatt International
Vincenzo Russo, Andrea Antonio Papa, Anna Rago, Carmine Ciardiello Eng, Gerardo Nigro
BACKGROUND: Atrial fibrillation (AF) is a common finding in myotonic dystrophy type 1 (DM1) population. Pacemakers may facilitate the diagnosis and management of frequent subclinical asymptomatic AF episodes. OBJECTIVE: To evaluate the effect of minimal ventricular pacing (MVP) on paroxysmal AF incidence in DM1 patients during a 24-month follow-up period. METHODS: We enrolled 70 DM1 patients (age 43.4 ± 13.8; 39 F) who underwent dual chamber pacemaker implantation...
March 7, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
Casper Lund-Andersen, Helen H Petersen, Christian Jøns, Berit T Philbert, Jacob Tfelt-Hansen, Lene T Skovgaard, Jesper H Svendsen
PURPOSE: Shortening of the QRS duration (QRSd) is often used to guide device optimization and reprogramming in patients with cardiac resynchronization therapy (CRT). Detecting the small changes expected during reprogramming requires that the QRSd can be measured with high precision, but this has never been studied in patients with CRT. In this study, we wanted to assess the precision of automated QRSd measurement in patients treated with CRT using two commonly available electrocardiographs...
March 5, 2018: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
Nancy Dong, Anthony Senzel, Kathy Li, Tom Z Lu, Cong-Hui Guo, Mila Aleksic, Zhong-Ping Feng
Activity-dependent transcription factors critically coordinate the gene expression program underlying memory formation. The tumour suppressor gene, MEN1, encodes a ubiquitously expressed transcription regulator required for synaptogenesis and synaptic plasticity in invertebrate and vertebrate central neurons. In this study, we investigated the role of MEN1 in long-term memory (LTM) formation in an aversive operant conditioning paradigm in the freshwater pond snail Lymnaea stagnalis (L. stagnalis). We demonstrated that LTM formation is associated with an increased expression of MEN1 coinciding with an up-regulation of creb1 gene expression...
February 26, 2018: Neuroscience
Kyoichiro Yazaki, Masahiro Watarai, Mitsuru Kahata, Asako Kumagai, Koji Inoue, Hiroshi Koganei, Kenji Enta, Masato Otsuka, Yasuhiro Ishii
A 67-year old male with a dual-chamber pacemaker visited for a regular check-up. An unfamiliar message emerged on the display just after placing the programmer wand. We could recognize that the pacemaker had already been in the safe back-up mode of DDI, and the programmer prompted a re-initialization request. We are so surprised because there was no indication of device malfunction the day before in daily monitoring and a 12-lead electrocardiogram revealed normally working in the DDD mode just before checking the device...
February 22, 2018: Indian Pacing and Electrophysiology Journal
Bogdan Caloian, Adela Viviana Sitar-Taut, Gabriel Nicolae Gusetu, Dana Pop, Dumitru Tudor Zdrenghea
BACKGROUND/AIM: The cardiac pacing mode influences the atrioventricular synchronicity and the response of the heart rate to physical exercise. The aim of this study was to compare the influence of the most common pacemaker programming modes on exercise capacity. PATIENTS AND METHODS: Fifty-two pacemaker-wearing patients were clinically evaluated and submitted to an exercise stress test. RESULTS: Symptoms of heart failure were more frequently met in the single-chamber pacemaker group compared to the dual-chamber group...
March 2018: In Vivo
Pietro Palmisano, Matteo Ziacchi, Mauro Biffi, Renato P Ricci, Maurizio Landolina, Massimo Zoni-Berisso, Eraldo Occhetta, Giampiero Maglia, Gianluca Botto, Luigi Padeletti, Giuseppe Boriani
: The purpose of this two-part consensus document is to provide specific suggestions (based on an extensive literature review) on appropriate pacemaker setting in relation to patients' clinical features. In part 2, criteria for pacemaker choice and programming in atrioventricular blocks and neurally mediate syncope are proposed. The atrioventricular blocks can be paroxysmal or persistent, isolated or associated with sinus node disease. Neurally mediated syncope can be related to carotid sinus syndrome or cardioinhibitory vasovagal syncope...
February 20, 2018: Journal of Cardiovascular Medicine
Matteo Ziacchi, Pietro Palmisano, Mauro Biffi, Renato P Ricci, Maurizio Landolina, Massimo Zoni-Berisso, Eraldo Occhetta, Giampiero Maglia, Gianluca Botto, Luigi Padeletti, Giuseppe Boriani
: Modern pacemakers have an increasing number of programable parameters and specific algorithms designed to optimize pacing therapy in relation to the individual characteristics of patients. When choosing the most appropriate pacemaker type and programing, the following variables must be taken into account: the type of bradyarrhythmia at the time of pacemaker implantation; the cardiac chamber requiring pacing, and the percentage of pacing actually needed to correct the rhythm disorder; the possible association of multiple rhythm disturbances and conduction diseases; the evolution of conduction disorders during follow-up...
April 2018: Journal of Cardiovascular Medicine
Anand D Shah, Mike A Morris, David S Hirsh, Megan Warnock, Yijian Huang, Mike Mollerus, Faisal M Merchant, Anshul M Patel, David B Delurgio, Adarsh U Patel, Michael H Hoskins, Mikhael F El Chami, Angel R Leon, Jonathan J Langberg, Michael S Lloyd
BACKGROUND: Recommendations regarding performance of MRI in non-MRI conditional pacemaker and defibrillator recipients are evolving. Previous studies suggest low adverse event rates with MRI in non-conditional CIED recipients, but low power limits optimal characterization of risk. OBJECTIVE: In order to improve power, a systematic review and meta-analysis was performed to characterize the clinical risk associated with MRI in CIED recipients. METHODS: PUBMED and CINAHL indexed articles from 1990-2017 were queried...
February 16, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
Elan D Louis, Daniel Trujillo Diaz, Sheng-Han Kuo, Shi-Rui Gan, Etty P Cortes, Jean Paul G Vonsattel, Phyllis L Faust
Background: In traditional models of essential tremor, the inferior olivary nucleus was posited to play a central role as the pacemaker for the tremor. However, recent data call this disease model into question. Case presentation: Our patient had progressive, long-standing, familial essential tremor. Upper limb tremor began at age 10 and worsened over time. It continued to worsen during the nine-year period he was enrolled in our brain donation program (age 85 - 94 years), during which time the tremor moved from the moderate to severe range on examination...
2018: Cerebellum & Ataxias
S Serge Barold, Nigel Lever, Fiona Riddell, Andreas Kucher
This report describes the occurrence of desynchronization in a patient with a cardiac resynchronization device programmed with an active pacemaker-mediated tachycardia algorithm based on AV delay modification. Desynchronization was precipitated by sinus tachycardia and the abrupt return of the prevailing AV delay that followed the periodic prolongation of the AV delay mandated by activity of the algorithm. Prevention of desynchronization in this setting requires programming a right ventricular upper rate interval longer than the sum of the programmed ventriculoatrial interval and the AV delay...
January 5, 2018: Indian Pacing and Electrophysiology Journal
Aimé Bonny, Marcus Ngantcha, Mohamed Jeilan, Emmy Okello, Bundhoo Kaviraj, Mohammed A Talle, George Nel, Eloi Marijon, Mahmoud U San, Zaheer Yousef, Kamilu M Karaye, Ibrahim A Touré, Mohamed A Awad, George Millogo, Jonas Kologo, Adama Kane, Romain Houndolo, Anastase Dzudié, Amam Mbakwem, Bongani M Mayosi, Ashley Chin
Aims: To provide comprehensive information on the access and use of cardiac implantable electronic devices (CIED) and catheter ablation procedures in Africa. Methods and results: The Pan-African Society of Cardiology (PASCAR) collected data on invasive management of cardiac arrhythmias from 2011 to 2016 from 31 African countries. A specific template was completed by physicians, and additional information obtained from industry. Information on health care systems, demographics, economics, procedure rates, and specific training programs was collected...
December 21, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
Victor P Kuznetsov, Georgy A Slivko-Koltchik, Dmitry A Voronov, Yuri V Panchin
The nervous system controls most rhythmic behaviors, with a remarkable exception. In Caenorhabditis elegans periodic defecation rhythm does not appear to involve the nervous system. Such oscillations are studied in detail with genetic and molecular biology tools. The small size of C. elegans cells impairs the use of standard electrophysiological methods. We studied a similar rhythmic pacemaker in the noticeably larger gut cells of Heterorhabditis megidis nematode. H. megidis defecation cycle is driven by a central pattern generator (CPG) associated with unusual all-or-none hyper-polarization "action potential"...
December 19, 2017: Scientific Reports
Luise Gaede, Johannes Blumenstein, Christoph Liebetrau, Oliver Dörr, Won-Keun Kim, Holger Nef, Oliver Husser, Albrecht Elsässer, Christian W Hamm, Helge Möllmann
Aims: We analysed the number of procedures, complications, and in-hospital mortality rates of all patients undergoing transvascular transcatheter aortic valve implantation (TV-TAVI) in comparison to isolated surgical aortic valve replacement (iSAVR) from 2014 to 2016 in Germany. Methods and results: All aortic valve procedures performed in Germany are mandatorily registered in a quality control program. More than 15 000 TV-TAVI procedures were performed in 2016 in Germany...
February 21, 2018: European Heart Journal
John Gierula, Maria F Paton, Judith E Lowry, Haqeel A Jamil, Rowenna Byrom, Michael Drozd, Jack O Garnham, Richard M Cubbon, David A Cairns, Mark T Kearney, Klaus K Witte
OBJECTIVES: This study sought to examine whether the heart rate (HR) at which the force-frequency relationship (FFR) slope peaks (critical HR) could be used to tailor HR response in chronic heart failure (CHF) patients with cardiac pacemakers and whether this favorably influences exercise capacity. BACKGROUND: CHF secondary to left ventricular (LV) systolic dysfunction is characterized by blunting of the positive relationship between HR and LV contractility known as the FFR...
February 2018: JACC. Heart Failure
Hiroshi Kawakami, Takayuki Nagai, Makoto Saito, Shinji Inaba, Fumiyasu Seike, Kazuhisa Nishimura, Katsuji Inoue, Takafumi Okura, Takumi Sumimoto, Shigeki Uemura, Jitsuo Higaki, Shuntaro Ikeda
Objective: The clinical significance of atrial high-rate episodes (AHREs) detected by cardiac devices among patients with implantable pacemakers has recently emerged. However, the relationship between AHREs and ischaemic stroke and systemic embolism (SE) is not well understood in the Japanese population. Methods: This study included 343 patients with pacemakers capable of continuous atrial rhythm monitoring (167 males; mean age, 80±7 years). Atrial tachyarrhythmia detection was programmed to the nominal setting of each device, and AHRE was defined as any episode of sustained atrial tachyarrhythmia lasting for more than 6 min...
2017: Heart Asia
Thomas G Gleason, John T Schindler, Robert C Hagberg, G Michael Deeb, David H Adams, John V Conte, George L Zorn, G Chad Hughes, Jia Guo, Jeffrey J Popma, Michael J Reardon
BACKGROUND: Iliofemoral arterial disease can preclude transfemoral (TF) transcatheter aortic valve replacement (TF-TAVR). Transthoracic access by direct aortic or a transapical approach imparts a greater risk of complications and death than TF access. We hypothesized that subclavian/axillary arterial (SCA) access offers equivalent risks and outcomes as TF access. METHODS: The outcomes of 202 patients from the CoreValve (Medtronic, Minneapolis, MN) United States Pivotal Trial Program treated with SCA access were propensity matched with patients treated with TF access and analyzed...
November 1, 2017: Annals of Thoracic Surgery
Maneesh K Rai, Mukund A Prabhu, Abhishek Sharma, Ritesh Vekariya, Padmanabh Kamath, Narasimha Pai, Ramanath L Kamath
BACKGROUND: Cardiac Resynchronization therapy (CRT) remains largely under-used in developing countries owing to the high cost of therapy. In this pilot study, we explore 'optimized' Left Ventricle Only Pacing (LVOP) as a cost effective alternative to cardiac resynchronization therapy in selected patients with heart failure. HYPOTHESIS: In economically poorer patients with heart failure, left bundle branch block (LBBB) and intact AV node conduction, synchronization can be obtained using a dual chamber pacemaker (leads in right atrium and Left ventricle) with the help of 2D strain imaging...
May 2017: Indian Pacing and Electrophysiology Journal
Frauke Hausburg, Julia Jeannine Jung, Robert David
Many disorders are manifested by dysfunction of key cell types or their disturbed integration in complex organs. Thereby, adult organ systems often bear restricted self-renewal potential and are incapable of achieving functional regeneration. This underlies the need for novel strategies in the field of cell (re-)programming-based regenerative medicine as well as for drug development in vitro. The regenerative field has been hampered by restricted availability of adult stem cells and the potentially hazardous features of pluripotent embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs)...
October 26, 2017: Advances in Biochemical Engineering/biotechnology
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