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grape seed extract

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https://www.readbyqxmd.com/read/28218448/chronic-supplementation-with-dietary-proanthocyanidins-protects-from-diet-induced-intestinal-alterations-in-obese-rats
#1
Gil-Cardoso Katherine, Ginés Iris, Pinent Montserrat, Ardévol Anna, Arola Lluís, Blay Mayte, Terra Ximena
SCOPE: Increased attention has been paid to the link between altered intestinal function and elevated incidence of metabolic disorders, such as in obesity. The present study investigated in obese rats the role of grape seed proanthocyanidin extract (GSPE) chronic treatment, taken in a low, moderate or high dose, on obesity-associated intestinal alterations in response to a cafeteria diet (CAF). METHODS AND RESULTS: To evaluate the degree of intestinal inflammation, ROS production and MPO activity were measured as well as the expression of inflammatory related genes...
February 20, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28208831/resveratrol-and-grape-extract-loaded-solid-lipid-nanoparticles-for-the-treatment-of-alzheimer-s-disease
#2
Joana A Loureiro, Stephanie Andrade, Ana Duarte, Ana Rute Neves, Joana Fontes Queiroz, Cláudia Nunes, Emmanuel Sevin, Laurence Fenart, Fabien Gosselet, Manuel A N Coelho, Maria Carmo Pereira
The aggregation of amyloid-β peptide (Aβ) has been linked to the formation of neuritic plaques, which are pathological hallmarks of Alzheimer's disease (AD). Various natural compounds have been suggested as therapeutics for AD. Among these compounds, resveratrol has aroused great interest due to its neuroprotective characteristics. Here, we provide evidence that grape skin and grape seed extracts increase the inhibition effect on Aβ aggregation. However, after intravenous injection, resveratrol is rapidly metabolized into both glucuronic acid and sulfate conjugations of the phenolic groups in the liver and intestinal epithelial cells (within less than 2 h), which are then eliminated...
February 13, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28208630/cocoa-and-grape-seed-byproducts-as-a-source-of-antioxidant-and-anti-inflammatory-proanthocyanidins
#3
María De La Luz Cádiz-Gurrea, Isabel Borrás-Linares, Jesús Lozano-Sánchez, Jorge Joven, Salvador Fernández-Arroyo, Antonio Segura-Carretero
Phenolic compounds, which are secondary plant metabolites, are considered an integral part of the human diet. Physiological properties of dietary polyphenols have come to the attention in recent years. Especially, proanthocyanidins (ranging from dimers to decamers) have demonstrated potential interactions with biological systems, such as antiviral, antibacterial, molluscicidal, enzyme-inhibiting, antioxidant, and radical-scavenging properties. Agroindustry produces a considerable amount of phenolic-rich sources, and the ability of polyphenolic structures to interacts with other molecules in living organisms confers their beneficial properties...
February 10, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28190469/proanthocyanidins-from-vitis-vinifera-inhibit-oxidative-stress-induced-vascular-impairment-in-pulmonary-arteries-from-diabetic-rats
#4
Christian Pinna, Paolo Morazzoni, Angelo Sala
BACKGROUND: Vitis vinifera L. (grape seed extract) is a natural source of proanthocyanidins with antioxidant and free radical-scavenging activities. HYPOTHESIS: Grape seed extract supplementation may prevent vascular endothelium impairment associated with diabetes mellitus in rat pulmonary artery. STUDY DESIGN: We evaluated endothelial function of rat pulmonary artery ex-vivo at the intermediate stage (4 weeks) of streptozotocin (STZ)-induced diabetes mellitus...
February 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28187454/grape-seed-extracts-modify-the-outcome-of-oxaliplatin-in-colon-cancer-cells-by-interfering-with-cellular-mechanisms-of-drug-cytotoxicity
#5
Letizia Porcelli, Rosa Maria Iacobazzi, Anna Elisa Quatrale, Carlo Bergamini, Nunzio Denora, Pasquale Crupi, Donato Antonacci, Anita Mangia, Giovanni Simone, Nicola Silvestris, Amalia Azzariti
Grape seed extracts are commonly utilized as dietary supplements for their antioxidant properties, even from cancer patients. However, whether these natural extracts interfere with chemotherapeutics utilized in colon cancer treatment is still poorly investigated. The cytotoxicity of extracts from Italia and Palieri cultivars either alone or in combination with oxaliplatin was evaluated in colon cancer cells. Grape seed extracts displayed anti-proliferative activity depending on the concentration utilized through apoptosis induction...
February 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28178683/gspe-reduces-lead-induced-oxidative-stress-by-activating-the-nrf2-pathway-and-suppressing-mir153-and-gsk-3%C3%AE-in-rat-kidney
#6
Biying Liu, Haili Zhang, Xiao Tan, Daqian Yang, Zhanjun Lv, Huijie Jiang, Jingjing Lu, Ruiqi Baiyun, Zhigang Zhang
Lead (Pb) is a global environmental health hazard that leads to nephrotoxicity. However, the effective treatment of Pb-induced nephrotoxicity remains elusive. Grape seed procyanidin extract (GSPE) has beneficial properties for multiple biological functions. Therefore, the present study investigated whether GSPE reduced Pb-induced nephrotoxicity as well as the protective mechanism of GSPE in a well-established 35-day Pb induced nephrotoxicity rat model. The results showed that GSPE normalized Pb-induced oxidative stress, histological damage, inflammatory, apoptosis, and changes of miR153 and glycogen synthase kinase 3β (GSK-3β) levels in rat kidney...
February 2, 2017: Oncotarget
https://www.readbyqxmd.com/read/28162106/chronic-administration-of-grape-seed-polyphenols-attenuates-the-development-of-hypertension-and-improves-other-cardiometabolic-risk-factors-associated-with-the-metabolic-syndrome-in-cafeteria-diet-fed-rats
#7
Zara Pons, Maria Margalef, Francisca I Bravo, Anna Arola-Arnal, Begoña Muguerza
The effects of grape-seed polyphenols against the development of hypertension and other cardiometabolic conditions associated with the metabolic syndrome (MetS) were studied in rats fed a high-fat, high-carbohydrate diet, known as the cafeteria (CAF) diet. Two groups of Wistar rats were fed standard (STD) or CAF diets for 12 weeks. The CAF diet-fed rats were administered different doses of a low-molecular-weight grape-seed polyphenol extract (LM-GSPE) (25, 100 and 200 mg/kg per d) or vehicle daily, and the STD diet-fed rats were administered LM-GSPE (100 mg/kg per d) or vehicle using ten animals per group...
February 6, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28153244/cyclic-voltammetry-to-evaluate-the-antioxidant-potential-in-winemaking-by-products
#8
M José Jara-Palacios, M Luisa Escudero-Gilete, J Miguel Hernández-Hierro, Francisco J Heredia, Dolores Hernanz
Grape pomace is composed of seeds, skins and stems that are an important source of phenolic substances, which have antioxidant properties and potential benefits to human health. Cyclic voltammetry (CV) has been used to measure the total antioxidant potential of different winemaking by-products. The electrochemical behavior of pomace, seeds, skins and stems was measured by CV and lipid peroxidation inhibition by thiobarbituric acid reactive substances (TBARS) method. Differences for the electrochemical parameter were found between the by-products, pomace and seeds, which presented the greatest voltammetric peak area...
April 1, 2017: Talanta
https://www.readbyqxmd.com/read/28144458/grape-seed-extract-supplementation-and-the-effects-on-the-biomarkers-of-oxidative-stress-and-metabolic-profiles-in-female-volleyball-players-a-randomized-double-blind-placebo-controlled-clinical-trial
#9
Mohsen Taghizadeh, Elaheh Malekian, Mohammad Reza Memarzadeh, Ali Akbar Mohammadi, Zatollah Asemi
BACKGROUND: Only limited data are available for evaluating the effects of the administration of grape seed extract (GSE) on the metabolic status of female volleyball players. OBJECTIVES: This study was conducted to determine the effects of GSE administration on the metabolic status of female volleyball players. METHODS: This randomized, double-blind, placebo-controlled clinical trial was performed among 40 female volleyball players. The subjects were randomly divided into two groups, with members of the test group (n = 20) taking 300 mg of GSE twice a day for eight weeks and members of the control group (n = 20) taking a placebo pearl for the same period...
September 2016: Iranian Red Crescent Medical Journal
https://www.readbyqxmd.com/read/28127316/in-vitro-evaluation-of-the-effect-of-herbal-antioxidants-on-shear-bond-strength-of-composite-resin-to-bleached-enamel
#10
Zahra Khamverdi, Parvin Khadem, Aliraza Soltanian, Maryam Azizi
OBJECTIVES: A reduction in bond strength of composite to bleached enamel has been reported immediately after bleaching treatment. Application of some antioxidant agents may decrease the adverse effects of whitening agents on bond strength and enhance composite bond to enamel. This study aimed to assess the effect of green tea, sodium ascorbate, sage and grape seed extract on bond strength of composite to bleached enamel. MATERIALS AND METHODS: In this in-vitro study, 90 human enamel surfaces were randomly divided into six groups as follows (n=15): G1, no bleaching; G2, bleaching with 40% hydrogen peroxide (HP); G3, HP+1000 μmol epigallocatechin gallate (EGCG) for 10 minutes; G4, HP+10% sodium ascorbate for 10 minutes; G5, HP+10% sage for 10 minutes and G6, HP+5% grape seed extract for 10 minutes...
August 2016: Journal of Dentistry of Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/28103873/masquelier-s-grape-seed-extract-from-basic-flavonoid-research-to-a-well-characterized-food-supplement-with-health-benefits
#11
REVIEW
Antje R Weseler, Aalt Bast
Careful characterization and standardization of the composition of plant-derived food supplements is essential to establish a cause-effect relationship between the intake of that product and its health effect. In this review we follow a specific grape seed extract containing monomeric and oligomeric flavan-3-ols from its creation by Jack Masquelier in 1947 towards a botanical remedy and nutraceutical with proven health benefits. The preparation's research history parallels the advancing insights in the fields of molecular biology, medicine, plant and nutritional sciences during the last 70 years...
January 19, 2017: Nutrition Journal
https://www.readbyqxmd.com/read/28074795/comparative-effect-of-grape-seed-extract-vitis-vinifera-and-ascorbic-acid-in-oxidative-stress-induced-by-on-pump-coronary-artery-bypass-surgery
#12
Naser Safaei, Hossein Babaei, Rasoul Azarfarin, Ahmad-Reza Jodati, Alireza Yaghoubi, Mohammad-Ali Sheikhalizadeh
BACKGROUND: This study aimed to test the beneficial effect of grape seed extract (GSE) (Vitis vinifera) and Vitamin C in oxidative stress and reperfusion injury induced by cardiopulmonary bypass (CPB) in coronary artery bypass surgery. PATIENTS AND METHODS: In this randomized trial, 87 patients undergoing elective and isolated coronary bypass surgery included. The patients were randomly assigned into three groups (n = 29 each): (1) Control group with no treatment, (2) GSE group who received the extract 24 h before operation, 100 mg every 6 h, orally, (3) Vitamin C group who received 25 mg/kg Vitamin C through CPB during surgery...
January 2017: Annals of Cardiac Anaesthesia
https://www.readbyqxmd.com/read/28031711/synergistic-anti-glioma-effect-of-a-coloaded-nano-drug-delivery-system
#13
Huae Xu, Feng Jia, Pankaj Kumar Singh, Shu Ruan, Hao Zhang, Xiaolin Li
The anti-glioma effect of temozolomide (Tem) is sometimes undermined by the emerging resistance. Recently, resveratrol (Res), herbal medicine extracted from grape seeds, has been demonstrated for its potential use in chemosensitization. In the current study, both these drugs were loaded simultaneously into nanoparticles with methoxy poly(ethylene glycol)-poly epsilon caprolactone (mPEG-PCL) as drug carriers in order to achieve better antitumor efficiency. Tem/Res-coloaded mPEG-PCL nanoparticles were constructed, characterized, and tested for antitumor effect on glioma cells by using in vitro and xenograft model system...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28027472/assessment-of-major-and-trace-element-bioavailability-in-vineyard-soil-applying-different-single-extraction-procedures-and-pseudo-total-digestion
#14
Tijana Milićević, Dubravka Relić, Sandra Škrivanj, Živoslav Tešić, Aleksandar Popović
A different single extraction procedures (CH3COOH, Na2EDTA, CaCl2, NH4NO3, deionized water), and pseudo-total digestion (aqua regia) were applied to determine major (Al, Fe, K, Mn, Na, P, S, and Si) and trace (Cd, Co, Cr, Cu, Mo, Ni, Pb, V, and Zn) element bioavailability in a topsoil from the experimental vineyard ("Radmilovac", Belgrade, Serbia). For the first time, the extraction with deionized water during 16 h was tested as an alternative method for isolating bioavailable major and trace elements from the soil...
December 19, 2016: Chemosphere
https://www.readbyqxmd.com/read/27990170/evaluation-of-wound-healing-properties-of-grape-seed-sesame-and-fenugreek-oils
#15
Dorsaf Moalla Rekik, Sameh Ben Khedir, Kamilia Ksouda Moalla, Naziha Grati Kammoun, Tarek Rebai, Zouheir Sahnoun
Background. Medicinal plants have proved at all times to be a powerful remedy for health care. Accordingly, grape seed, sesame, and fenugreek extracted oils with pharmacological properties are investigated as wound treatments. This study assesses the potential of our oils for healing wounds induced on rats. Methods. Phytochemical analyses of oils have involved: quality value, polyphenol, chlorophylls, carotene, and fatty acids. Antibacterial activity was carried out. Antioxidant activity was evaluated: the scavenging effect on DPPH radicals, the reducing power, and β-carotene discoloration...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27984208/oral-administration-of-grape-seed-polyphenol-extract-restores-memory-deficits-in-chronic-cerebral-hypoperfusion-rats
#16
Chen Chen, Yake Zheng, Tianwen Wu, Chuanjie Wu, Xuan Cheng
Chronic cerebral hypoperfusion (CCH) has been recognized as an important cause of both vascular dementia and Alzheimer's disease (AD), the two most prominent neurodegenerative diseases causing memory impairment in the elderly. However, an effective therapy for CCH-induced memory impairment has not yet been established. Grape seed polyphenol extract (GSPE) has powerful antioxidant properties and protects neurons and glia during ischemic injury, but its potential use in the prevention of CCH-induced memory impairment has not yet been investigated...
December 14, 2016: Behavioural Pharmacology
https://www.readbyqxmd.com/read/27979147/evaluation-of-the-influence-of-white-grape-seed-extracts-as-copigment-sources-on-the-anthocyanin-extraction-from-grape-skins-previously-classified-by-near-infrared-hyperspectral-tools
#17
Julio Nogales-Bueno, Berta Baca-Bocanegra, María José Jara-Palacios, José Miguel Hernández-Hierro, Francisco José Heredia
Hyperspectral imaging has been used to classify red grapes (Vitis vinifera L.) according to their predicted extractable total anthocyanin content (i.e. extractable total anthocyanin content determined by a hyperspectral method). Low, medium and high levels of predicted extractable total anthocyanin content were established. Then, grape skins were split into three parts and each part was macerated into a different model wine solution for a three-day period. Wine model solutions were made up with different concentration of copigments coming from white grape seeds...
April 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27933323/assessing-collagen-and-micro-permeability-at-the-proanthocyanidin-treated-resin-dentin-interface
#18
Berdan Aydin, Lina Saleh Hassan, Grace Viana, Ana K Bedran-Russo
PURPOSE: To establish a fluorescence-based method to simultaneously assess micro-permeability and collagen cross-linking induced by chemical agents at the resin-dentin interface. MATERIALS AND METHODS: Three chemical agents were investigated (proanthocyanidin-rich grape seed extract: GSE; carbodiimide hydrochloride/N-hydroxysuccinimide: EDC/NHS; glutaraldehyde: GD) along with a control (distilled water) as primers applied on flat occlusal dentin surfaces of 48 teeth and restored with two commercially available etch-and-rinse adhesives...
December 8, 2016: Journal of Adhesive Dentistry
https://www.readbyqxmd.com/read/27927886/biostability-of-the-proanthocyanidins-dentin-complex-and-adhesion-studies
#19
A A Leme-Kraus, B Aydin, C M P Vidal, R M Phansalkar, J W Nam, J McAlpine, G F Pauli, S Chen, A K Bedran-Russo
Oligomeric proanthocyanidins (OPACs) are potent and renewable natural bioactives possible to be refined into chemically standardized mixtures for biological applications. Herein, we found that multiscale interactions of OPACs with the dentin matrix create tight biointerfaces with hydrophobic methacrylate adhesives on wet surfaces. An enriched mixture of OPACs, with a known phytochemical profile, was produced from grape seed crude extract (Vitis vinifera; enriched grape seed extract [e-GSE]) and applied to dentin matrices to determine changes to the mechanical properties and biodegradability of the dentin matrix and favorable resin adhesion mechanisms...
December 7, 2016: Journal of Dental Research
https://www.readbyqxmd.com/read/27892838/effect-of-bioactive-primers-on-bacterial-induced-secondary-caries-at-the-tooth-resin-interface
#20
G E Kim, A A Leme-Kraus, R Phansalkar, G Viana, C Wu, S-N Chen, G F Pauli, Akb Bedran-Russo
Secondary caries at the tooth-resin interface is the primary reason for replacement of resin composite restorations. The tooth-resin interface is formed by the interlocking of resin material with hydroxyapatite crystals in enamel and collagen mesh structure in dentin. Efforts to strengthen the tooth-resin interface have identified chemical agents with dentin collagen cross-linking potential and antimicrobial activities. The purpose of the present study was to assess protective effects of bioactive primer against secondary caries development around enamel and dentin margins of class V restorations, using an in vitro bacterial caries model...
November 28, 2016: Operative Dentistry
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