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grape seed extract

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https://www.readbyqxmd.com/read/29352129/molecular-characterization-of-the-grape-seeds-extract-s-effect-against-chemically-induced-liver-cancer-in-vivo-and-in-vitro-analyses
#1
Alaaeldin Ahmed Hamza, Gehan Hussein Heeba, Hanan Mohamed Elwy, Chandraprabha Murali, Raafat El-Awady, Amr Amin
The purpose of this study was to investigate the anti-cancer property of grape seed extract (GSE) during early stages of developing liver cancer using a two-stage carcinogenic model combining diethylnitrosamine (DEN) and 2-Acetyl Aminofluorene (2-AAF). Administration of GSE at doses 25, 50 and 100 mg/kg per day started at the beginning of promotion periods and continued for 14 weeks. GSE dramatically inhibited pre-neoplastic foci formation as well as significantly decreased the number and the area of placental glutathione-S-transferase in livers of DEN-2AAF-treated rats by approximately 4 & 10 fold deductions, respectively...
January 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29349878/efficacy-of-grape-seed-extract-gel-in-the-treatment-of-chronic-periodontitis-a-randomized-clinical-study
#2
Mohammad Rayyan, Tammam Terkawi, Hajer Abdo, Dalia Abdel Azim, Aseel Khalaf, Zenab AlKhouli, Maha Meziad, Marwa Alshamma'a, Horiyah Abu Naim
AIM: The aim of the present study was to assess the effectiveness of applying grape seed extract (GSE) gel in periodontal pockets for the treatment of chronic periodontitis. METHODS: Eighty-six sites with pocket depth (PD) >4 mm were selected from five systemically-healthy patients in whom scaling, and root planing were performed, and oral instructions were given, a week earlier. PD, gingival index (GI), plaque index (PI), and bleeding on probing (BOP) were measured, and sites were then divided into the control group (N = 38) and GSE group (N = 48)...
January 18, 2018: Journal of Investigative and Clinical Dentistry
https://www.readbyqxmd.com/read/29331852/no-time-to-waste-organic-waste-nanosizing-converts-remains-of-food-processing-into-refined-materials
#3
Sharoon Griffin, Muhammad Sarfraz, Verda Farida, Muhammad Jawad Nasim, Azubuike P Ebokaiwe, Cornelia M Keck, Claus Jacob
Modern food processing results in considerable amounts of side-products, such as grape seeds, walnut shells, spent coffee grounds, and harvested tomato plants. These materials are still rich in valuable and biologically active substances and therefore of interest from the perspective of waste management and "up-cycling". In contrast to traditional, often time consuming and low-value uses, such as vermicomposting and anaerobic digestion, the complete conversion into nanosuspensions unlocks considerable potentials of and new applications for such already spent organic materials without the need of extraction and without producing any additional waste...
January 11, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29331224/centrifugal-partition-chromatography-enables-selective-enrichment-of-trimeric-and-tetrameric-proanthocyanidins-for-biomaterial-development
#4
Rasika S Phansalkar, Joo-Won Nam, Shao-Nong Chen, James B McAlpine, Ariene A Leme, Berdan Aydin, Ana-Karina Bedran-Russo, Guido F Pauli
Proanthocyanidins (PACs) find wide applications for human use including food, cosmetics, dietary supplements, and pharmaceuticals. The chemical complexity associated with PACs has triggered the development of various chromatographic techniques, with countercurrent separation (CCS) gaining in popularity. This study applied the recently developed DESIGNER (Depletion and Enrichment of Select Ingredients Generating Normalized Extract Resources) approach for the selective enrichment of trimeric and tetrameric PACs using centrifugal partition chromatography (CPC)...
December 21, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29280676/testing-for-human-norovirus-and-recovery-of-process-control-in-outbreak-associated-produce-items
#5
Kaoru Hida, Efstathia Papafragkou, Michael Kulka
The development of rapid and sensitive detection methods for human noroviruses (HuNoV) in produce items is critical, especially with the recent rise in outbreaks associated with this food commodity. In this study, 50-g portions of various produce items linked to a norovirus outbreak (celery, cucumber, lettuce, grapes, and radish) were artificially inoculated with murine norovirus (MNV-1) and concentrated either by ultracentrifugation or polyethylene glycol (PEG) precipitation after elution with an alkaline Tris-glycine-beef extract buffer supplemented with pectinase...
December 27, 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/29279544/use-of-grape-seed-extract-for-improving-the-shear-bond-strength-of-total-etching-adhesive-to-bleached-enamel
#6
Yingxin Xu, Jianfeng Zhou, Jianguo Tan
This study was to ascertain if grape seed extract (GSE) can restore the shear bond strength (SBS) of total-etching adhesive to enamel immediately after bleaching. Immediately after bleaching with Beyond gel, different concentrations of GSE were applied to the surface of bovine enamel for 1 min before bonding of resin composite with Adper single bond 2 or All-Bond 3 adhesive. SBS values and debonding modes were recorded. Structure of the bonding interface and elements on enamel surface were analyzed by scanning electron microscopy and X-ray photoelectron spectroscopy (XPS)...
December 27, 2017: Dental Materials Journal
https://www.readbyqxmd.com/read/29240945/transcript-profiling-indicates-a-widespread-role-for-bacterial-type-phosphoenolpyruvate-carboxylase-in-malate-accumulating-sink-tissues
#7
Michael K Y Ting, Yi-Min She, William C Plaxton
Phosphoenolpyruvate carboxylase (PEPC) is an important regulatory enzyme situated at a key branch point of central plant metabolism. Plant genomes encode several plant-type PEPC (PTPC) isozymes, along with a distantly related bacterial-type PEPC (BTPC). BTPC is expressed at high levels in developing castor oil seeds where it tightly interacts with co-expressed PTPC polypeptides to form unusual hetero-octameric Class-2 PEPC complexes that are desensitized to allosteric inhibition by L-malate. Analysis of RNA-Seq and microarray transcriptome datasets revealed two distinct patterns of tissue-specific BTPC expression in vascular plants...
December 16, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/29227543/edible-coating-using-a-chitosan-based-colloid-incorporating-grapefruit-seed-extract-for-cherry-tomato-safety-and-preservation
#8
Jin Sung Won, Seung Jo Lee, Hyeon Hwa Park, Kyung Bin Song, Sea C Min
Grapefruit seed extract (GSE)-containing chitosan-based coating was developed and applied to cherry tomatoes to protect them from Salmonella invasion and improve their storability. The coating colloids were produced by mixing a chitosan colloid (1% [w/w] chitosan) with GSE at various concentrations (0.5%, 0.7%, 1.0%, and 1.2% [w/w]) using high-shear mixing (10000 rpm, 2 min). Coatings with chitosan colloids containing GSE at 0.0%, 0.5%, 0.7%, and 1.0% (w/w) inactivated Salmonella on cherry tomatoes by 1.0 ± 0...
December 11, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/29223045/investigation-of-antioxidant-ability-of-grape-seeds-extract-to-prevent-oxidatively-induced-dna-damage-by-gas-chromatography-tandem-mass-spectrometry
#9
Önder Aybastıer, Sam Dawbaa, Cevdet Demir
Phenolic compounds have been studied elaborately for their efficacy to improve health and to protect against a wide variety of diseases. Herein this study, different analysis methods were implemented to evaluate the antioxidant properties of catechin and cyanidin using their standard substances and as they found in the grape seeds extracts. Total phenol contents were 107.39±8.94mg GAE/g dw of grape seeds for grape seed extract (GSE) and 218.32±10.66mg GAE/g dw of grape seeds for acid-hydrolyzed grape seed extract (AcGSE)...
December 6, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29211130/dentin-sealing-and-bond-strength-evaluation-of-hema-free-and-multi-mode-adhesives-to-biomodified-dentin
#10
Renata Bacelar-Sá, Marcelo Giannini, Glaucia Maria Bovi Ambrosano, Ana Karina Bedran-Russo
This study evaluated the effect of dentin biomodification on the bond strength (BS) and sealing ability (SA) of HEMA-free and multi-mode adhesives after 24 h and 6 months of water storage. Four adhesives were tested: two multi-mode (Scotchbond Universal - SU, and Prime & Bond Elect - PB) and two HEMA-free (All-Bond 3 - AB, and G-Aenial - GA). Human third molars were selected and dentin was treated with two cross-linking agents (5% glutaraldehyde and 6.5% proanthocyanidin-rich grape seed extract - PACs) for 10 min or kept untreated (control group) (n=6)...
November 2017: Brazilian Dental Journal
https://www.readbyqxmd.com/read/29189132/polyphenols-novel-signaling-pathways
#11
Marie-Louise Ricketts, Bradley S Ferguson
BACKGROUND: Cardiovascular disease (CVD) is currently the leading cause of death globally. The metabolic syndrome (MetS), a clustering of risk factors including hypertension, hyperglycemia, elevated low-density lipoprotein (LDL) cholesterol, reduced high-density lipoprotein (HDL) cholesterol and increased visceral adiposity, is a significant risk factor for the development of CVD. Non-alcoholic fatty liver disease (NAFLD), often referred to as the hepatic manifestation of MetS, is a constellation of progressive liver disorders closely linked to obesity, diabetes, and insulin resistance...
November 29, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29188040/evaluation-of-peanut-skin-and-grape-seed-extracts-to-inhibit-growth-of-foodborne-pathogens
#12
Jason Levy, Renee R Boyer, Andrew P Neilson, Sean F O'Keefe, Hyun Sik S Chu, Robert C Williams, Melanie R Dorenkott, Katheryn M Goodrich
Peanut skin extract (PSE) and grape seed extract (GSE) are derived from waste products in the wine and peanut industries, respectively. Both have high concentrations of polyphenols, known to possess antioxidant and antimicrobial properties. PSE primarily contains "A-type" procyanidins, while GSE primarily contains "B-type" procyanidins. These differ structurally, but are both isomers of epicatechin dimers. The objective of this study was to evaluate the antimicrobial effects of PSE containing A-type procyanidins and GSE containing B-type procyanidins against select foodborne pathogens (Listeria monocytogenes, Escherichia coli O157:H7, and Salmonella Typhimurium)...
November 2017: Food Science & Nutrition
https://www.readbyqxmd.com/read/29175668/grape-seed-procyanidin-extract-ameliorates-lead-induced-liver-injury-via-mirna153-and-akt-gsk-3%C3%AE-fyn-mediated-nrf2-activation
#13
Biying Liu, Huijie Jiang, Jingjing Lu, Ruiqi Baiyun, Siyu Li, Yueying Lv, Da Li, Hao Wu, Zhigang Zhang
Lead-induced hepatotoxicity is characterized by an extensive oxidative stress. Grape seed procyanidin extract (GSPE) possesses abundant biological activities. Herein, we investigated the protective role of GSPE against lead-induced liver injury and determined the potential molecular mechanisms. In vivo, rats were treated with/without lead acetate (PbAc) (0.05%, w/v) in the presence/absence of GSPE (200 mg/kg). In vitro, hepatocytes were pretreated with/without GSPE (100 μg/ml) in the presence/absence of PbAc (100 μM)...
October 12, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29174497/antioxidant-action-of-grape-seed-polyphenols-and-aerobic-exercise-in-improving-neuronal-number-in-the-hippocampus-is-associated-with-decrease-in-lipid-peroxidation-and-hydrogen-peroxide-in-adult-and-middle-aged-rats
#14
S Abhijit, Sunil Jamuna Tripathi, V Bhagya, B S Shankaranarayana Rao, Muthangi V Subramanyam, S Asha Devi
The present study explored the effects of swimming training and grape seed proanthocyanidin extract (GSPE) on neuronal survival in the hippocampus (HC) of middle-aged rats along with oxidative stress (OS) parameters. Further, the bioavailability of the GSPE, catechin, epicatechin and gallic acid were measured in the HC and plasma. Male Wistar rats were grouped into: sedentary control, SE-C; swimming trained, SW-T; SE-C, supplemented sedentary, SE-C(PA) and swimming trainees, SW-T(PA). The supplement was a daily dose of 400mg GSPE/kg body weight...
November 22, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/29172735/effects-of-ganoderma-rhodiola-and-grape-seed-extracts-on-the-glucuronidation-and-oral-bioavailability-of-resveratrol-in-rats
#15
Zhaoqing Cong, Man Zhou, Feifei Yang, Chunyu Liu, Ruile Pan, Qi Chang, Xinmin Liu, Yonghong Liao
Herb extracts were shown to inhibit the activity of UDP-glucuronosyltransferases (UGTs) in vitro. However, the actual in vivo effect of the inhibitory ability on oral bioavailability is yet verified. In this study, resveratrol (RES) was used as a model drug to study the effect of three Chinese herb extracts, Ganoderma, Rhodiola and grape seed, on the in vitro and in vivo inhibition of glucuronidation and the in vivo bioavailability of RES. Overall, although herb extracts might show inhibition on glucuronidation of RES in vitro and in vivo, the inhibition of glucuronidation did not necessarily mean to improve the in vivo bioavailability of RES...
November 26, 2017: Natural Product Research
https://www.readbyqxmd.com/read/29169010/oxidative-stress-burden-inhibits-spermatogenesis-in-adult-male-rats-testosterone-protective-effect
#16
Samy Makary, Mohamed Abdo, Ereny Fekry
In this study, we aimed to investigate the protective effects of androgens, using letrozole (LET; an aromatase inhibitor), grape seed extract (GSE; a naturally occurring aromatase inhibitor and antioxidant), and testosterone propionate (Tp), against methotrexate (MTX)-induced testicular toxicity in adult male rats. MTX has been shown to induce oxidative stress and exhibit antiproliferative effects in the testes. Adult male rats received oral saline gavage (control group with no treatment), the potential protective agents (LET, GSE, or Tp) alone, MTX alone, or a combination of one of the potential protective agents and MTX...
November 23, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/29162031/norgal-extraction-and-de-novo-assembly-of-mitochondrial-dna-from-whole-genome-sequencing-data
#17
Kosai Al-Nakeeb, Thomas Nordahl Petersen, Thomas Sicheritz-Pontén
BACKGROUND: Whole-genome sequencing (WGS) projects provide short read nucleotide sequences from nuclear and possibly organelle DNA depending on the source of origin. Mitochondrial DNA is present in animals and fungi, while plants contain DNA from both mitochondria and chloroplasts. Current techniques for separating organelle reads from nuclear reads in WGS data require full reference or partial seed sequences for assembling. RESULTS: Norgal (de Novo ORGAneLle extractor) avoids this requirement by identifying a high frequency subset of k-mers that are predominantly of mitochondrial origin and performing a de novo assembly on a subset of reads that contains these k-mers...
November 21, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/29158566/graphene-quantum-dots-for-cell-proliferation-nucleus-imaging-and-photoluminescent-sensing-applications
#18
Mukesh Kumar Kumawat, Mukeshchand Thakur, Raju B Gurung, Rohit Srivastava
We report a simple one-pot microwave assisted "green synthesis" of Graphene Quantum Dots (GQDs) using grape seed extract as a green therapeutic carbon source. These GQDs readily self-assemble, hereafter referred to as "self-assembled" GQDs (sGQDs) in the aqueous medium. The sGQDs enter via caveolae and clathrin-mediated endocytosis and target themselves into cell nucleus within 6-8 h without additional assistance of external capping/targeting agent. The tendency to self-localize themselves into cell nucleus also remains consistent in different cell lines such as L929, HT-1080, MIA PaCa-2, HeLa, and MG-63 cells, thereby serving as a nucleus labelling agent...
November 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29152654/nephrin-loss-is-reduced-by-grape-seed-proanthocyanidins-in-the-experimental-diabetic-nephropathy-rat-model
#19
Xianhua Li, Zhaoli Gao, Haiqing Gao, Baoying Li, Tao Peng, Bei Jiang, Xiangdong Yang, Zhao Hu
Diabetic nephropathy (DN) is one of the major causes of end‑stage renal failure. Grape seed proanthocyanidin extracts (GSPE) are known to act as antioxidants. The current study aimed to determine the effects of GSPE on the streptozotocin (STZ)‑induced diabetic rat model and to explore the underlying mechanism of its action. Wistar rats were induced into a diabetic state by injection of STZ and were treated with 250 mg·kg‑1·day‑1 GSPE for 24 weeks. Kidney samples were collected for observation of renal pathological changes by light microscope (periodic acid‑Schiff staining) and electron microscopy...
October 19, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29140290/ameliorative-effects-of-grape-seed-proanthocyanidin-extract-on-growth-performance-immune-function-antioxidant-capacity-biochemical-constituents-liver-histopathology-and-aflatoxin-residues-in-broilers-exposed-to-aflatoxin-b%C3%A2
#20
Shahid Ali Rajput, Lvhui Sun, Niya Zhang, Mahmoud Mohamed Khalil, Xin Gao, Zhao Ling, Luoyi Zhu, Farhan Anwar Khan, Jiacai Zhang, Desheng Qi
Aflatoxicosis is a grave threat to the poultry industry. Dietary supplementation with antioxidants showed a great potential in enhancing the immune system; hence, protecting animals against aflatoxin B₁-induced toxicity. Grape seed proanthocyanidin extract (GSPE) one of the most well-known and powerful antioxidants. Therefore, the purpose of this research was to investigate the effectiveness of GSPE in the detoxification of AFB₁ in broilers. A total of 300 one-day-old Cobb chicks were randomly allocated into five treatments of six replicates (10 birds per replicate), fed ad libitum for four weeks with the following dietary treatments: 1...
November 15, 2017: Toxins
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