Raquel Vieira Niella, Janaína Maria Xavier Corrêa, João Felipe Ribeiro Dos Santos, Larissa Ferreira Lima, Claire Souza da Costa Marques, Luciano Cardoso Santos, Larissa Rodrigues Santana, Álvaro José Chávez Silva, Keilane Silva Farias, Carlos Priminho Pirovani, Juneo Freitas Silva, Mário Sérgio Lima de Lavor
OBJECTIVE: To determine the effective dose and therapeutic potential of maropitant using through expression of mediators of oxidative stress, inflammatory and of the unfolded protein response (UPR) (bio) markers on spinal cord using a model of neuropathic pain induced through chronic constriction injury (CCI) in rats. STUDY DESIGN: Randomized, blinded, prospective experimental study. ANIMALS: 98 male Wistar rats. METHODS: Rats were anesthetized with sevoflurane and after CCI, they were randomly assigned to the following groups that received: vehicle, 3, 6, 15, 30 e 50 mg/kg/24q of maropitant...
2024: PloS One