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https://www.readbyqxmd.com/read/27763552/maporal-hantavirus-causes-mild-pathology-in-deer-mice-peromyscus-maniculatus
#1
Amanda McGuire, Kaitlyn Miedema, Joseph R Fauver, Amber Rico, Tawfik Aboellail, Sandra L Quackenbush, Ann Hawkinson, Tony Schountz
Rodent-borne hantaviruses can cause two human diseases with many pathological similarities: hantavirus cardiopulmonary syndrome (HCPS) in the western hemisphere and hemorrhagic fever with renal syndrome in the eastern hemisphere. Each virus is hosted by specific reservoir species without conspicuous disease. HCPS-causing hantaviruses require animal biosafety level-4 (ABSL-4) containment, which substantially limits experimental research of interactions between the viruses and their reservoir hosts. Maporal virus (MAPV) is a South American hantavirus not known to cause disease in humans, thus it can be manipulated under ABSL-3 conditions...
October 18, 2016: Viruses
https://www.readbyqxmd.com/read/27398256/how-much-effort-is-required-to-accurately-describe-the-complex-ecology-of-a-rodent-borne-viral-disease
#2
Richard J Douglass, María Victoria Vadell
We use data collected on 18,1-ha live trapping grids monitored from 1994 through 2005 and on five of those grids through 2013 in the mesic northwestern US to illustrate the complexity of the deer mouse (Peromyscus maniculatus)/Sin Nombre virus (SNV) host-pathogen system. Important factors necessary to understand zoonotic disease ecology include those associated with distribution and population dynamics of reservoir species as well as infection dynamics. Results are based on more than 851,000 trap nights, 16,608 individual deer mice and 10,572 collected blood samples...
June 2016: Ecosphere
https://www.readbyqxmd.com/read/27112283/historical-perspective-what-constitutes-discovery-of-a-new-virus
#3
F A Murphy
A historic review of the discovery of new viruses leads to reminders of traditions that have evolved over 118 years. One such tradition gives credit for the discovery of a virus to the investigator(s) who not only carried out the seminal experiments but also correctly interpreted the findings (within the technological context of the day). Early on, ultrafiltration played a unique role in "proving" that an infectious agent was a virus, as did a failure to find any microscopically visible agent, failure to show replication of the agent in the absence of viable cells, thermolability of the agent, and demonstration of a specific immune response to the agent so as to rule out duplicates and close variants...
2016: Advances in Virus Research
https://www.readbyqxmd.com/read/26955081/toward-a-mechanistic-understanding-of-environmentally-forced-zoonotic-disease-emergence-sin-nombre-hantavirus
#4
Scott Carver, James N Mills, Cheryl A Parmenter, Robert R Parmenter, Kyle S Richardson, Rachel L Harris, Richard J Douglass, Amy J Kuenzi, Angela D Luis
Understanding the environmental drivers of zoonotic reservoir and human interactions is crucial to understanding disease risk, but these drivers are poorly predicted. We propose a mechanistic understanding of human-reservoir interactions, using hantavirus pulmonary syndrome as a case study. Crucial processes underpinning the disease's incidence remain poorly studied, including the connectivity among natural and peridomestic deer mouse host activity, virus transmission, and human exposure. We found that disease cases were greatest in arid states and declined exponentially with increasing precipitation...
July 1, 2015: Bioscience
https://www.readbyqxmd.com/read/26559827/crystal-structure-of-the-core-region-of-hantavirus-nucleocapsid-protein-reveals-the-mechanism-for-ribonucleoprotein-complex-formation
#5
Yu Guo, Wenming Wang, Yuna Sun, Chao Ma, Xu Wang, Xin Wang, Pi Liu, Shu Shen, Baobin Li, Jianping Lin, Fei Deng, Hualin Wang, Zhiyong Lou
UNLABELLED: Hantaviruses, which belong to the genus Hantavirus in the family Bunyaviridae, infect mammals, including humans, causing either hemorrhagic fever with renal syndrome (HFRS) or hantavirus cardiopulmonary syndrome (HCPS) in humans with high mortality. Hantavirus encodes a nucleocapsid protein (NP) to encapsidate the genome and form a ribonucleoprotein complex (RNP) together with viral polymerase. Here, we report the crystal structure of the core domains of NP (NPcore) encoded by Sin Nombre virus (SNV) and Andes virus (ANDV), which are two representative members that cause HCPS in the New World...
January 2016: Journal of Virology
https://www.readbyqxmd.com/read/25943457/assessing-prevention-measures-and-sin-nombre-hantavirus-seroprevalence-among-workers-at-yosemite-national-park
#6
Jason A Wilken, Rebecca Jackson, Barbara L Materna, Gayle C Windham, Barryett Enge, Sharon Messenger, Dongxiang Xia, Barbara Knust, Danielle Buttke, Rachel Roisman
BACKGROUND: During 2012, a total of 10 overnight visitors to Yosemite National Park (Yosemite) became infected with a hantavirus (Sin Nombre virus [SNV]); three died. SNV infections have been identified among persons with occupational exposure to deer mice (Peromyscus maniculatus). METHODS: We assessed SNV infection prevalence, work and living environments, mice exposures, and SNV prevention training, knowledge, and practices among workers of two major employers at Yosemite during September-October, 2012 by voluntary blood testing and a questionnaire...
June 2015: American Journal of Industrial Medicine
https://www.readbyqxmd.com/read/25856432/transcriptome-markers-of-viral-persistence-in-naturally-infected-andes-virus-bunyaviridae-seropositive-long-tailed-pygmy-rice-rats
#7
Corey L Campbell, Fernando Torres-Perez, Mariana Acuna-Retamar, Tony Schountz
Long-tailed pygmy rice rats (Oligoryzomys longicaudatus) are principal reservoir hosts of Andes virus (ANDV) (Bunyaviridae), which causes most hantavirus cardiopulmonary syndrome cases in the Americas. To develop tools for the study of the ANDV-host interactions, we used RNA-Seq to generate a de novo transcriptome assembly. Splenic RNA from five rice rats captured in Chile, three of which were ANDV-infected, was used to generate an assembly of 66,173 annotated transcripts, including noncoding RNAs. Phylogenetic analysis of selected predicted proteins showed similarities to those of the North American deer mouse (Peromyscus maniculatus), the principal reservoir of Sin Nombre virus (SNV)...
2015: PloS One
https://www.readbyqxmd.com/read/25725074/isolation-identification-and-whole-genome-sequencing-of-reticuloendotheliosis-virus-from-a-vaccine-against-marek-s-disease
#8
Junping Li, Xuan Dong, Chenghuai Yang, Qihong Li, Zhizhong Cui, Shuang Chang, Peng Zhao, Kangzhen Yu, Hanchun Yang
According to the requirements of the Ministry of Agriculture of China, all vaccines must be screened for exogenous virus contamination before commercialization. A freeze-dried vaccine against Marek's disease was used to inoculate specific pathogen-free chickens, from which serum samples were collected after 42 days. The results were positive for reticuloendotheliosis virus antibody, which was indicative of reticuloendotheliosis virus contamination. After neutralization with serum positive for Marek's disease virus, chicken embryo fibroblasts were inoculated with the vaccine...
April 2015: Poultry Science
https://www.readbyqxmd.com/read/25674766/elevated-cytokines-thrombin-and-pai-1-in-severe-hcps-patients-due-to-sin-nombre-virus
#9
Virginie Bondu, Ron Schrader, Mary Ann Gawinowicz, Paul McGuire, Daniel A Lawrence, Brian Hjelle, Tione Buranda
Sin Nombre Hantavirus (SNV, Bunyaviridae Hantavirus) is a Category A pathogen that causes Hantavirus Cardiopulmonary Syndrome (HCPS) with case fatality ratios generally ranging from 30% to 50%. HCPS is characterized by vascular leakage due to dysregulation of the endothelial barrier function. The loss of vascular integrity results in non-cardiogenic pulmonary edema, shock, multi-organ failure and death. Using Electric Cell-substrate Impedance Sensing (ECIS) measurements, we found that plasma samples drawn from University of New Mexico Hospital patients with serologically-confirmed HCPS, induce loss of cell-cell adhesion in confluent epithelial and endothelial cell monolayers grown in ECIS cultureware...
February 2015: Viruses
https://www.readbyqxmd.com/read/25429055/dna-vaccine-derived-human-igg-produced-in-transchromosomal-bovines-protect-in-lethal-models-of-hantavirus-pulmonary-syndrome
#10
Jay W Hooper, Rebecca L Brocato, Steven A Kwilas, Christopher D Hammerbeck, Matthew D Josleyn, Michael Royals, John Ballantyne, Hua Wu, Jin-an Jiao, Hiroaki Matsushita, Eddie J Sullivan
Polyclonal immunoglobulin-based medical products have been used successfully to treat diseases caused by viruses for more than a century. We demonstrate the use of DNA vaccine technology and transchromosomal bovines (TcBs) to produce fully human polyclonal immunoglobulins (IgG) with potent antiviral neutralizing activity. Specifically, two hantavirus DNA vaccines [Andes virus (ANDV) DNA vaccine and Sin Nombre virus (SNV) DNA vaccine] were used to produce a candidate immunoglobulin product for the prevention and treatment of hantavirus pulmonary syndrome (HPS)...
November 26, 2014: Science Translational Medicine
https://www.readbyqxmd.com/read/24970702/serological-diagnosis-of-hantavirus-pulmonary-syndrome-in-a-febrile-patient-in-colombia
#11
Salim Mattar, Denisse Garzon, Luis Tadeu, Alvaro A Faccini-Martínez, James N Mills
Hantavirus pulmonary syndrome (HPS) is an often fatal rodent-borne zoonosis caused by any of at least 20 hantavirus genotypes distributed throughout the Americas. Although HPS has been documented in several bordering countries, it has not been reported in Colombia. Here we report seroconversion to a hantavirus in paired samples from a hospitalized patient with symptoms compatible with HPS from Montería, Córdoba Department, north-western Colombia. Tests for regionally endemic agents including Plasmodium, Leptospira, Salmonella, dengue virus, Brucella, Rickettsia, human immunodeficiency virus and hepatitis viruses were negative...
August 2014: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/24910509/grazing-effects-on-deer-mice-with-implications-to-human-exposure-to-sin-nombre-virus
#12
Abigail J Leary, Amy J Kuenzi, Richard J Douglass
We examined the effects of grazing on deer mouse (Peromyscus maniculatus) movements into buildings using passive integrated transponder (PIT) technology and small simulated buildings located on 0.6-ha treatment (grazing) and control (no grazing) plots. Twelve experimental 9-day trials were conducted over the course of the study. During these trials, mouse movements into buildings were monitored during three time periods (each 3 days in length). In the treatment plots these time periods corresponded to pre-grazing, grazing, and post grazing by horses...
December 2011: Intermountain Journal of Sciences: IJS
https://www.readbyqxmd.com/read/24867065/a-hantavirus-pulmonary-syndrome-hps-dna-vaccine-delivered-using-a-spring-powered-jet-injector-elicits-a-potent-neutralizing-antibody-response-in-rabbits-and-nonhuman-primates
#13
Steve Kwilas, Jennifer M Kishimori, Matthew Josleyn, Kurt Jerke, John Ballantyne, Michael Royals, Jay W Hooper
Sin Nombre virus (SNV) and Andes virus (ANDV) cause most of the hantavirus pulmonary syndrome (HPS) cases in North and South America, respectively. The chances of a patient surviving HPS are only two in three. Previously, we demonstrated that SNV and ANDV DNA vaccines encoding the virus envelope glycoproteins elicit high-titer neutralizing antibodies in laboratory animals, and (for ANDV) in nonhuman primates (NHPs). In those studies, the vaccines were delivered by gene gun or muscle electroporation. Here, we tested whether a combined SNV/ANDV DNA vaccine (HPS DNA vaccine) could be delivered effectively using a disposable syringe jet injection (DSJI) system (PharmaJet, Inc)...
2014: Current Gene Therapy
https://www.readbyqxmd.com/read/24829335/differential-lymphocyte-and-antibody-responses-in-deer-mice-infected-with-sin-nombre-hantavirus-or-andes-hantavirus
#14
COMPARATIVE STUDY
Tony Schountz, Sandra Quackenbush, Joel Rovnak, Elaine Haddock, William C Black, Heinz Feldmann, Joseph Prescott
UNLABELLED: Hantavirus cardiopulmonary syndrome (HCPS) is a rodent-borne disease with a high case-fatality rate that is caused by several New World hantaviruses. Each pathogenic hantavirus is naturally hosted by a principal rodent species without conspicuous disease and infection is persistent, perhaps for life. Deer mice (Peromyscus maniculatus) are the natural reservoirs of Sin Nombre virus (SNV), the etiologic agent of most HCPS cases in North America. Deer mice remain infected despite a helper T cell response that leads to high-titer neutralizing antibodies...
August 2014: Journal of Virology
https://www.readbyqxmd.com/read/24817814/effect-of-rock-cover-on-small-mammal-abundance-in-a-montana-grassland
#15
Kyle Richardson, Scott Carver, Richard Douglass, Amy Kuenzi
We examined the influence of rock cover, as an indicator of presumable retreat site availability on the abundance of deer mice (Peromyscus maniculatus) and prevalence of Sin Nombre virus (SNV) using long-term live trapping and habitat data from three live trapping grids and a short-term (three month), spatially replicated study across three slopes in Cascade County, Montana. In our long-term study, we found that deer mice were more abundant at a live-trapping grid with greater rock cover, than two grids with less rock cover...
December 2011: Intermountain Journal of Sciences: IJS
https://www.readbyqxmd.com/read/24806874/rapid-enzyme-linked-immunosorbent-assay-for-the-detection-of-hantavirus-specific-antibodies-in-divergent-small-mammals
#16
Karla Cautivo, Tony Schountz, Mariana Acuña-Retamar, Marcela Ferrés, Fernando Torres-Pérez
We assessed the utility of an enzyme-linked immunosorbent assay (ELISA) for the detection of hantavirus-specific antibodies from sera of Oligoryzomys longicaudatus, the principal reservoir of Andes virus (ANDV), using an antigen previously developed for detection of antibodies to Sin Nombre virus (SNV) in sera from Peromyscus maniculatus. The assay uses a protein A/G horseradish peroxidase conjugate and can be performed in as little as 1.5 hours. Serum samples from Oligoryzomys longicaudatus collected in central-south Chile were used and the assay identified several that were antibody positive...
May 2014: Viruses
https://www.readbyqxmd.com/read/24778254/pathophysiology-of-hantavirus-pulmonary-syndrome-in-rhesus-macaques
#17
David Safronetz, Joseph Prescott, Friederike Feldmann, Elaine Haddock, Rebecca Rosenke, Atsushi Okumura, Douglas Brining, Eric Dahlstrom, Stephen F Porcella, Hideki Ebihara, Dana P Scott, Brian Hjelle, Heinz Feldmann
The pathophysiology of hantavirus pulmonary syndrome (HPS) remains unclear because of a lack of surrogate disease models with which to perform pathogenesis studies. Nonhuman primates (NHP) are considered the gold standard model for studying the underlying immune activation/suppression associated with immunopathogenic viruses such as hantaviruses; however, to date an NHP model for HPS has not been described. Here we show that rhesus macaques infected with Sin Nombre virus (SNV), the primary etiological agent of HPS in North America, propagated in deer mice develop HPS, which is characterized by thrombocytopenia, leukocytosis, and rapid onset of respiratory distress caused by severe interstitial pneumonia...
May 13, 2014: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/24652355/-serological-evidence-of-hanta-virus-infection-bunyaviridae-hantavirus-in-rodents-from-the-sucre-department-in-colombia
#18
Pedro Blanco, Stiven Arroyo, Homer Corrales, Julia Pérez, Lercy Álvarez, Anaís Castellar
OBJECTIVE: The main goal of this research was to determine the frequency of hantavirus-specific antibodies in rodents from the municipality of San Marcos in the Sucre department of Colombia. METHODS: 144 rodents were captured in San Marcos' urban and rural areas using Sherman traps between December 2007 and July 2009. "Virus sin Nombre" (SNV)-specific antibodies were detected in plasma samples by an indirect ELISA immunoassay. RESULTS: An 8...
October 2012: Revista de Salud Pública
https://www.readbyqxmd.com/read/24631566/simultaneous-detection-of-igg-antibodies-associated-with-viral-hemorrhagic-fever-by-a-multiplexed-luminex-based-immunoassay
#19
Wei Wu, Shuo Zhang, Jing Qu, Quanfu Zhang, Chuan Li, Jiandong Li, Cong Jin, Mifang Liang, Dexin Li
Viral hemorrhagic fevers (VHFs) are worldwide diseases caused by several kinds of viruses. With the emergence of new viruses, advanced diagnostic methods are urgently needed for identification of VHFs. Based on Luminex xMAP technology, a rapid, sensitive, multi-pathogen and high-throughput method which could simultaneously detect hemorrhagic fever viruses (HFVs) specific IgG antibodies was developed. Recombinant antigens of nine HFVs including Hantaan virus (HTNV), Seoul virus (SEOV), Puumala virus (PUUV), Andes virus (ANDV), Sin Nombre virus (SNV), Crimean-Congo hemorrhagic fever virus (CCHFV), Rift Valley fever virus (RVFV), Severe fever with thrombocytopenia syndrome bunyavirus (SFTSV) and dengue virus (DENV) were produced and purified from a prokaryotic expression system and the influence of the coupling amount was investigated...
July 17, 2014: Virus Research
https://www.readbyqxmd.com/read/24618810/equilibrium-and-kinetics-of-sin-nombre-hantavirus-binding-at-daf-cd55-functionalized-bead-surfaces
#20
Tione Buranda, Scarlett Swanson, Virginie Bondu, Leah Schaefer, James Maclean, Zhenzhen Mo, Keith Wycoff, Archana Belle, Brian Hjelle
Decay accelerating factor (DAF/CD55) is targeted by many pathogens for cell entry. It has been implicated as a co-receptor for hantaviruses. To examine the binding of hantaviruses to DAF, we describe the use of Protein G beads for binding human IgG Fc domain-functionalized DAF ((DAF)₂-Fc). When mixed with Protein G beads the resulting DAF beads can be used as a generalizable platform for measuring kinetic and equilibrium binding constants of DAF binding targets. The hantavirus interaction has high affinity (24-30 nM; k(on) ~ 10⁵ M⁻¹ s⁻¹, k(off) ~ 0...
2014: Viruses
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