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https://www.readbyqxmd.com/read/29077702/a-lethal-disease-model-for-new-world-hantaviruses-using-immunosuppressed-syrian-hamsters
#1
Valentijn Vergote, Lies Laenen, Bert Vanmechelen, Marc Van Ranst, Erik Verbeken, Jay W Hooper, Piet Maes
BACKGROUND: Hantavirus, the hemorrhagic causative agent of two clinical diseases, is found worldwide with variation in severity, incidence and mortality. The most lethal hantaviruses are found on the American continent where the most prevalent viruses like Andes virus and Sin Nombre virus are known to cause hantavirus pulmonary syndrome. New World hantavirus infection of immunocompetent hamsters results in an asymptomatic infection except for Andes virus and Maporal virus; the only hantaviruses causing a lethal disease in immunocompetent Syrian hamsters mimicking hantavirus pulmonary syndrome in humans...
October 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28977768/interspecific-comparison-of-hantavirus-prevalence-in-peromyscus-populations-from-a-fragmented-agro-ecosystem-in-indiana
#2
Jacob L Berl, Amy J Kuenzi, Elizabeth A Flaherty, Robert K Swihart
Comparatively little is known about hantavirus prevalence within rodent populations from the Midwestern US, where two species of native mice, the prairie deer mouse (Peromyscus maniculatus bairdii) and the white-footed mouse (Peromyscus leucopus noveboracensis), are dominant members of rodent communities. We sampled both species in central Indiana and tested individuals for presence of hantavirus antibodies to determine whether seroprevalence (percent of individuals with antibodies reactive to Sin Nombre virus antigen) differed between species, or among different habitat types within fragmented agro-ecosystems...
October 4, 2017: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/28977767/evaluating-the-impacts-of-coinfection-on-immune-system-function-of-the-deer-mouse-peromyscus-maniculatus-using-sin-nombre-virus-and-bartonella-as-model-pathogen-systems
#3
Erin M Lehmer, Kathryn Lavengood, Mason Miller, Jacob Rodgers, Steven D Fenster
Simultaneous infections with multiple pathogens can alter the function of the host's immune system, often resulting in additive or synergistic morbidity. We examined how coinfection with the common pathogens Sin Nombre virus (SNV) and Bartonella sp. affected aspects of the adaptive and innate immune responses of wild deer mice (Peromyscus maniculatus). Adaptive immunity was assessed by measuring SNV antibody production; innate immunity was determined by measuring levels of C-reactive protein (CRP) in blood and the complement activity of plasma...
October 4, 2017: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/28835374/low-affinity-binding-in-cis-to-p2y2r-mediates-force-dependent-integrin-activation-during-hantavirus-infection
#4
Virginie Bondu, Chenyu Wu, Wenpeng Cao, Peter C Simons, Jennifer Gillette, Jieqing Zhu, Laurie Erb, X Frank Zhang, Tione Buranda
Pathogenic hantaviruses bind to the plexin-semaphorin-integrin (PSI) domain of inactive, β3 integrins. Previous studies have implicated a cognate cis interaction between the bent conformation β5/β3 integrins and an arginine-glycine-aspartic acid (RGD) sequence in the first extracellular loop of P2Y2R. With single-molecule atomic force microscopy, we show a specific interaction between an atomic force microscopy tip decorated with recombinant αIIbβ3 integrins and (RGD)P2Y2R expressed on cell membranes. Mutation of the RGD sequence to RGE in the P2Y2R removes this interaction...
October 15, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/28714801/muleshoe-virus-and-other-hantaviruses-associated-with-neotomine-or-sigmodontine-rodents-in-texas
#5
Mary Louise Milazzo, Maria N B Cajimat, Martin H Richter, Robert D Bradley, Charles F Fulhorst
The broad objective of this study was to increase our knowledge of Muleshoe virus and other hantaviruses associated with cricetid rodents in Texas. Anti-hantavirus antibody was found in 38 (3.2%) of 1171 neotomine rodents and 6 (1.8%) of 332 sigmodontine rodents from 10 Texas counties; hantaviral RNA was detected in 23 (71.9%) of 32 antibody-positive rodents. Analyses of nucleocapsid protein gene sequences indicated Muleshoe virus infection in four hispid cotton rats (Sigmodon hispidus) from northern Texas; Bayou virus, three Texas marsh oryzomys (Oryzomys texensis) from the Gulf Coast; Limestone Canyon virus, five brush mice (Peromyscus boylii) from western Texas; and Sin Nombre virus-five Texas mice (P...
October 2017: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/28584450/t-cell-epitopes-predicted-from-the-nucleocapsid-protein-of-sin-nombre-virus-restricted-to-30-hla-alleles-common-to-the-north-american-population
#6
Sathish Sankar, Mageshbabu Ramamurthy, Balaji Nandagopal, Gopalan Sridharan
Hantavirus cardiopulmonary syndrome in North America is caused by Sin Nombre virus (SNV) and poses a public health problem. We identified T-cell epitopes restricted to HLA alleles commonly seen in the N. American population. Nucleocapsid (N) protein is 428 aminoacid in length and binds to RNA and functions also as a key molecule between virus and host cell processes. The predicted epitopes from N protein that bind to class I MHC were analyzed for human proteasomes cleavage, TAP efficiency, immunogenicity and antigenicity...
2017: Bioinformation
https://www.readbyqxmd.com/read/28105849/antiviral-therapy-and-prevention-against-hantavirus-infections
#7
R Szabó
Hantaviruses are emerging zoonoses hosted by small mammals. In humans, they cause two diseases. Hemorrhagic fever with renal syndrome is mainly caused by Dobrava-Belgrade virus, Puumala virus, Seoul virus and Hantaan virus in Asia and Europe. On the other hand, the most important causes of hantavirus cardiopulmonary syndrome are Sin Nombre virus and Andes virus in Americas. Ribavirin yet remains the only licensed drug against the hantavirus infections, but its sufficient antiviral activity remains an issue under discussion...
2017: Acta Virologica
https://www.readbyqxmd.com/read/28103211/notes-from-the-field-hantavirus-pulmonary-syndrome-in-a-migrant-farm-worker-colorado-2016
#8
Grace Marx, Kaylan Stinson, Monte Deatrich, Bernadette Albanese
HASH(0x3873d08)
January 20, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/27763552/maporal-hantavirus-causes-mild-pathology-in-deer-mice-peromyscus-maniculatus
#9
Amanda McGuire, Kaitlyn Miedema, Joseph R Fauver, Amber Rico, Tawfik Aboellail, Sandra L Quackenbush, Ann Hawkinson, Tony Schountz
Rodent-borne hantaviruses can cause two human diseases with many pathological similarities: hantavirus cardiopulmonary syndrome (HCPS) in the western hemisphere and hemorrhagic fever with renal syndrome in the eastern hemisphere. Each virus is hosted by specific reservoir species without conspicuous disease. HCPS-causing hantaviruses require animal biosafety level-4 (ABSL-4) containment, which substantially limits experimental research of interactions between the viruses and their reservoir hosts. Maporal virus (MAPV) is a South American hantavirus not known to cause disease in humans, thus it can be manipulated under ABSL-3 conditions...
October 18, 2016: Viruses
https://www.readbyqxmd.com/read/27398256/how-much-effort-is-required-to-accurately-describe-the-complex-ecology-of-a-rodent-borne-viral-disease
#10
Richard J Douglass, María Victoria Vadell
We use data collected on 18,1-ha live trapping grids monitored from 1994 through 2005 and on five of those grids through 2013 in the mesic northwestern US to illustrate the complexity of the deer mouse (Peromyscus maniculatus)/Sin Nombre virus (SNV) host-pathogen system. Important factors necessary to understand zoonotic disease ecology include those associated with distribution and population dynamics of reservoir species as well as infection dynamics. Results are based on more than 851,000 trap nights, 16,608 individual deer mice and 10,572 collected blood samples...
June 2016: Ecosphere
https://www.readbyqxmd.com/read/27112283/historical-perspective-what-constitutes-discovery-of-a-new-virus
#11
REVIEW
F A Murphy
A historic review of the discovery of new viruses leads to reminders of traditions that have evolved over 118 years. One such tradition gives credit for the discovery of a virus to the investigator(s) who not only carried out the seminal experiments but also correctly interpreted the findings (within the technological context of the day). Early on, ultrafiltration played a unique role in "proving" that an infectious agent was a virus, as did a failure to find any microscopically visible agent, failure to show replication of the agent in the absence of viable cells, thermolability of the agent, and demonstration of a specific immune response to the agent so as to rule out duplicates and close variants...
2016: Advances in Virus Research
https://www.readbyqxmd.com/read/26955081/toward-a-mechanistic-understanding-of-environmentally-forced-zoonotic-disease-emergence-sin-nombre-hantavirus
#12
Scott Carver, James N Mills, Cheryl A Parmenter, Robert R Parmenter, Kyle S Richardson, Rachel L Harris, Richard J Douglass, Amy J Kuenzi, Angela D Luis
Understanding the environmental drivers of zoonotic reservoir and human interactions is crucial to understanding disease risk, but these drivers are poorly predicted. We propose a mechanistic understanding of human-reservoir interactions, using hantavirus pulmonary syndrome as a case study. Crucial processes underpinning the disease's incidence remain poorly studied, including the connectivity among natural and peridomestic deer mouse host activity, virus transmission, and human exposure. We found that disease cases were greatest in arid states and declined exponentially with increasing precipitation...
July 1, 2015: Bioscience
https://www.readbyqxmd.com/read/26559827/crystal-structure-of-the-core-region-of-hantavirus-nucleocapsid-protein-reveals-the-mechanism-for-ribonucleoprotein-complex-formation
#13
Yu Guo, Wenming Wang, Yuna Sun, Chao Ma, Xu Wang, Xin Wang, Pi Liu, Shu Shen, Baobin Li, Jianping Lin, Fei Deng, Hualin Wang, Zhiyong Lou
UNLABELLED: Hantaviruses, which belong to the genus Hantavirus in the family Bunyaviridae, infect mammals, including humans, causing either hemorrhagic fever with renal syndrome (HFRS) or hantavirus cardiopulmonary syndrome (HCPS) in humans with high mortality. Hantavirus encodes a nucleocapsid protein (NP) to encapsidate the genome and form a ribonucleoprotein complex (RNP) together with viral polymerase. Here, we report the crystal structure of the core domains of NP (NPcore) encoded by Sin Nombre virus (SNV) and Andes virus (ANDV), which are two representative members that cause HCPS in the New World...
January 2016: Journal of Virology
https://www.readbyqxmd.com/read/25943457/assessing-prevention-measures-and-sin-nombre-hantavirus-seroprevalence-among-workers-at-yosemite-national-park
#14
Jason A Wilken, Rebecca Jackson, Barbara L Materna, Gayle C Windham, Barryett Enge, Sharon Messenger, Dongxiang Xia, Barbara Knust, Danielle Buttke, Rachel Roisman
BACKGROUND: During 2012, a total of 10 overnight visitors to Yosemite National Park (Yosemite) became infected with a hantavirus (Sin Nombre virus [SNV]); three died. SNV infections have been identified among persons with occupational exposure to deer mice (Peromyscus maniculatus). METHODS: We assessed SNV infection prevalence, work and living environments, mice exposures, and SNV prevention training, knowledge, and practices among workers of two major employers at Yosemite during September-October, 2012 by voluntary blood testing and a questionnaire...
June 2015: American Journal of Industrial Medicine
https://www.readbyqxmd.com/read/25856432/transcriptome-markers-of-viral-persistence-in-naturally-infected-andes-virus-bunyaviridae-seropositive-long-tailed-pygmy-rice-rats
#15
Corey L Campbell, Fernando Torres-Perez, Mariana Acuna-Retamar, Tony Schountz
Long-tailed pygmy rice rats (Oligoryzomys longicaudatus) are principal reservoir hosts of Andes virus (ANDV) (Bunyaviridae), which causes most hantavirus cardiopulmonary syndrome cases in the Americas. To develop tools for the study of the ANDV-host interactions, we used RNA-Seq to generate a de novo transcriptome assembly. Splenic RNA from five rice rats captured in Chile, three of which were ANDV-infected, was used to generate an assembly of 66,173 annotated transcripts, including noncoding RNAs. Phylogenetic analysis of selected predicted proteins showed similarities to those of the North American deer mouse (Peromyscus maniculatus), the principal reservoir of Sin Nombre virus (SNV)...
2015: PloS One
https://www.readbyqxmd.com/read/25725074/isolation-identification-and-whole-genome-sequencing-of-reticuloendotheliosis-virus-from-a-vaccine-against-marek-s-disease
#16
Junping Li, Xuan Dong, Chenghuai Yang, Qihong Li, Zhizhong Cui, Shuang Chang, Peng Zhao, Kangzhen Yu, Hanchun Yang
According to the requirements of the Ministry of Agriculture of China, all vaccines must be screened for exogenous virus contamination before commercialization. A freeze-dried vaccine against Marek's disease was used to inoculate specific pathogen-free chickens, from which serum samples were collected after 42 days. The results were positive for reticuloendotheliosis virus antibody, which was indicative of reticuloendotheliosis virus contamination. After neutralization with serum positive for Marek's disease virus, chicken embryo fibroblasts were inoculated with the vaccine...
April 2015: Poultry Science
https://www.readbyqxmd.com/read/25674766/elevated-cytokines-thrombin-and-pai-1-in-severe-hcps-patients-due-to-sin-nombre-virus
#17
Virginie Bondu, Ron Schrader, Mary Ann Gawinowicz, Paul McGuire, Daniel A Lawrence, Brian Hjelle, Tione Buranda
Sin Nombre Hantavirus (SNV, Bunyaviridae Hantavirus) is a Category A pathogen that causes Hantavirus Cardiopulmonary Syndrome (HCPS) with case fatality ratios generally ranging from 30% to 50%. HCPS is characterized by vascular leakage due to dysregulation of the endothelial barrier function. The loss of vascular integrity results in non-cardiogenic pulmonary edema, shock, multi-organ failure and death. Using Electric Cell-substrate Impedance Sensing (ECIS) measurements, we found that plasma samples drawn from University of New Mexico Hospital patients with serologically-confirmed HCPS, induce loss of cell-cell adhesion in confluent epithelial and endothelial cell monolayers grown in ECIS cultureware...
February 2015: Viruses
https://www.readbyqxmd.com/read/25429055/dna-vaccine-derived-human-igg-produced-in-transchromosomal-bovines-protect-in-lethal-models-of-hantavirus-pulmonary-syndrome
#18
Jay W Hooper, Rebecca L Brocato, Steven A Kwilas, Christopher D Hammerbeck, Matthew D Josleyn, Michael Royals, John Ballantyne, Hua Wu, Jin-an Jiao, Hiroaki Matsushita, Eddie J Sullivan
Polyclonal immunoglobulin-based medical products have been used successfully to treat diseases caused by viruses for more than a century. We demonstrate the use of DNA vaccine technology and transchromosomal bovines (TcBs) to produce fully human polyclonal immunoglobulins (IgG) with potent antiviral neutralizing activity. Specifically, two hantavirus DNA vaccines [Andes virus (ANDV) DNA vaccine and Sin Nombre virus (SNV) DNA vaccine] were used to produce a candidate immunoglobulin product for the prevention and treatment of hantavirus pulmonary syndrome (HPS)...
November 26, 2014: Science Translational Medicine
https://www.readbyqxmd.com/read/24970702/serological-diagnosis-of-hantavirus-pulmonary-syndrome-in-a-febrile-patient-in-colombia
#19
Salim Mattar, Denisse Garzon, Luis Tadeu, Alvaro A Faccini-Martínez, James N Mills
Hantavirus pulmonary syndrome (HPS) is an often fatal rodent-borne zoonosis caused by any of at least 20 hantavirus genotypes distributed throughout the Americas. Although HPS has been documented in several bordering countries, it has not been reported in Colombia. Here we report seroconversion to a hantavirus in paired samples from a hospitalized patient with symptoms compatible with HPS from Montería, Córdoba Department, north-western Colombia. Tests for regionally endemic agents including Plasmodium, Leptospira, Salmonella, dengue virus, Brucella, Rickettsia, human immunodeficiency virus and hepatitis viruses were negative...
August 2014: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/24910509/grazing-effects-on-deer-mice-with-implications-to-human-exposure-to-sin-nombre-virus
#20
Abigail J Leary, Amy J Kuenzi, Richard J Douglass
We examined the effects of grazing on deer mouse (Peromyscus maniculatus) movements into buildings using passive integrated transponder (PIT) technology and small simulated buildings located on 0.6-ha treatment (grazing) and control (no grazing) plots. Twelve experimental 9-day trials were conducted over the course of the study. During these trials, mouse movements into buildings were monitored during three time periods (each 3 days in length). In the treatment plots these time periods corresponded to pre-grazing, grazing, and post grazing by horses...
December 2011: Intermountain Journal of Sciences: IJS
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