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Navroop K Dhaliwal, Kamelia Miri, Scott Davidson, Hala Tamim El Jarkass, Jennifer A Mitchell
Cooperative action of a transcription factor complex containing OCT4, SOX2, NANOG, and KLF4 maintains the naive pluripotent state; however, less is known about the mechanisms that disrupt this complex, initiating exit from pluripotency. We show that, as embryonic stem cells (ESCs) exit pluripotency, KLF4 protein is exported from the nucleus causing rapid decline in Nanog and Klf4 transcription; as a result, KLF4 is the first pluripotency transcription factor removed from transcription-associated complexes during differentiation...
March 1, 2018: Stem Cell Reports
Kiran Dhaliwal, Michelle Griffin, Christopher P Denton, Peter E M Butler
Raynaud's phenomenon is a vasospastic disorder of the digital vessels triggered by exposure to cold or stress. It is most commonly observed in the hands, but also frequently affects the toes. We present three cases of patients with severe Raynaud's phenomenon in the toes, secondary to scleroderma. The diagnosis of Raynaud's syndrome and scleroderma was established according to the 2010 American College of Rheumatology and European League Against Rheumatism criteria. Patients were treated with 10 units of botulinum toxin injected into each foot...
March 9, 2018: BMJ Case Reports
Richard J Alsop, Sebastian Himbert, Alexander Dhaliwal, Karin Schmalzl, Maikel C Rheinstädter
Local structure and dynamics of lipid membranes play an important role in membrane function. The diffusion of small molecules, the curvature of lipids around a protein and the existence of cholesterol-rich lipid domains (rafts) are examples for the membrane to serve as a functional interface. The collective fluctuations of lipid tails, in particular, are relevant for diffusion of membrane constituents and small molecules in and across membranes, and for structure and formation of membrane domains. We studied the effect of aspirin (acetylsalicylic acid, ASA) on local structure and dynamics of membranes composed of dimyristoylphosphocholine (DMPC) and cholesterol...
February 2018: Royal Society Open Science
N Mundi, J Theurer, A Warner, J Yoo, K Fung, D MacNeil, S Dhaliwal, E Winquist, D A Palma, A C Nichols
Background: Operating room slowdowns occur at specific intervals in the year as a cost-saving measure. We aim to investigate the impact of these slowdowns on the care of oral cavity cancer patients at a Canadian tertiary care centre. Methods: A total of 585 oral cavity cancer patients seen between 1999 and 2015 at the London Health Science Centre (lhsc) Head and Neck Multidisciplinary Clinic were included in this study. Operating room hours and patient load from 2006 to 2014 were calculated...
February 2018: Current Oncology
Keegan Lutek, Rasmeet Singh Dhaliwal, Terence J Van Raay, Andreas Heyland
Settlement is a rapid process in many marine invertebrate species, transitioning a planktonic larva into a benthic juvenile. In indirectly developing sea urchins, this ecological transition correlates with a morphological, developmental and physiological transition (metamorphosis) during which apoptosis is essential for the resorption and remodelling of larval and juvenile structures. While settlement is initiated by environmental cues (i.e. habitat-specific or benthic substrate cues), metamorphosis is regulated by developmental endocrine signals, such as histamine (HA), thyroid hormones (THs) and nitric oxide (NO)...
March 5, 2018: Scientific Reports
Gurpreet Dhaliwal, Kaveh G Shojania
No abstract text is available yet for this article.
March 5, 2018: BMJ Quality & Safety
Yu Zhan, Christophe H Marchand, Alexandre Maes, Adeline Mauries, Yi Sun, James S Dhaliwal, James Uniacke, Simon Arragain, Heng Jiang, Nicholas D Gold, Vincent J J Martin, Stéphane D Lemaire, William Zerges
Organelles are intracellular compartments which are themselves compartmentalized. Biogenic and metabolic processes are localized to specialized domains or microcompartments to enhance their efficiency and suppress deleterious side reactions. An example of intra-organellar compartmentalization is the pyrenoid in the chloroplasts of algae and hornworts. This microcompartment enhances the photosynthetic CO2-fixing activity of the Calvin-Benson cycle enzyme Rubisco, suppresses an energetically wasteful oxygenase activity of Rubisco, and mitigates limiting CO2 availability in aquatic environments...
2018: PloS One
Sidharth Kumar Sethi, Arushi Nautiyal, Alka Rana, Rajan Duggal, Ashish Nandwani, Dinesh Yadav, Amit Mahapatra, Maninder Dhaliwal, Veena Raghunathan, Shyam Bihari Bansal
No abstract text is available yet for this article.
February 26, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
Sidharth Kumar Sethi, Arushi Nautiyal, Alka Rana, Rajan Duggal, Ashish Nandwani, Dinesh Yadav, Amit Mahapatra, Maninder Dhaliwal, Veena Raghunathan, Shyam Bihari Bansal
No abstract text is available yet for this article.
February 26, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
Mohit Girotra, Kaartik Soota, Amaninder S Dhaliwal, Rtika R Abraham, Mauricio Garcia-Saenz-de-Sicilia, Benjamin Tharian
Hepatocellular carcinoma constitutes over 90% of the primary liver tumors, the rest being cholangiocarcinoma. It has an insidious presentation, which is responsible for the delayed presentation. Hence, the management strategy relies on screening to diagnose it an early stage for curative resection and/or treatment with local ablative techniques or chemotherapy. However, even with different screening programs, more than 60% of tumors are still detected at an advanced stage, leading to an unchanged mortality rate, thereby implying a room for improvement in the screening and diagnostic process...
February 16, 2018: World Journal of Gastrointestinal Endoscopy
Amy Nau, Deepinder K Dhaliwal
No abstract text is available yet for this article.
March 2018: Eye & Contact Lens
Kevin N Keane, Peter M Hinchliffe, Philip K Rowlands, Gayatri Borude, Shanti Srinivasan, Satvinder S Dhaliwal, John L Yovich
Background: In vitro fertilization (IVF) patients receive various adjuvant therapies to enhance success rates, but the true benefit is actively debated. Growth hormone (GH) and dehydroepiandrosterone (DHEA) supplementation were assessed in women undergoing fresh IVF transfer cycles and categorized as poor prognosis from five criteria. Methods: Data were retrospectively analyzed from 626 women undergoing 626 IVF cycles, where they received no adjuvant, GH alone, or GH-DHEA in combination...
2018: Frontiers in Endocrinology
Karamjit Dhaliwal, Victoria Malkhasyan, Mohammed Elhassan
Overutilization of diagnostic imaging can lead to unnecessary interventions and subsequently can jeopardize patient safety. When ordered, the results of these images should always be interpreted in the appropriate clinical context taking into consideration the patient clinical presentation and the natural history of the diseases which are being investigated. We presented a case that demonstrates for the practicing physicians how violating these two notions can lead ultimately to patient harm.
2018: Journal of Community Hospital Internal Medicine Perspectives
Georg E Matt, Penelope J E Quintana, Eunha Hoh, Joy M Zakarian, Zohir Chowdhury, Melbourne F Hovell, Peyton Jacob, Kayo Watanabe, Teaba S Theweny, Victoria Flores, Anh Nguyen, Narinder Dhaliwal, Gary Hayward
BACKGROUND: Secondhand smoke (SHS) in US casinos is common, but little is known about the residue of tobacco smoke pollutants left behind in dust and on surfaces, commonly referred to as thirdhand smoke (THS). We examined SHS and THS pollution and exposure before and during a casino smoking ban and after smoking resumed. METHODS: A casino was visited nine times over a 15-month period to collect dust, surface and air samples in eight locations. Finger wipe and urine samples were collected from non-smoking confederates before and after a 4-hour casino visit...
February 8, 2018: Tobacco Control
K Agrawal, Shalini Gainder, Lakhbir K Dhaliwal, Vanita Suri
Objective: To determine the efficacy of the stair-step protocol (SSP) using clomiphene citrate (CC) in patients with polycystic ovary syndrome (PCOS) and compare it with traditional regimen. Design: This was randomized control trial. Setting: Infertility Clinic. Patients: Sixty infertile PCOS women. Interventions: Patients were randomized into the study (SSP - 30 patients) and control group (traditional protocol - 30 patients)...
October 2017: Journal of Human Reproductive Sciences
Geak Poh Tan, Nigel McArdle, Satvinder Singh Dhaliwal, Jane Douglas, Clare Siobhan Rea, Bhajan Singh
Home mechanical ventilation (HMV) is used in a wide range of disorders associated with chronic hypoventilation. We describe the patterns of use, survival and predictors of death in Western Australia. We identified 240 consecutive patients (60% male; mean age 58 years and body mass index 31 kg m-2) referred for HMV between 2005 and 2010. The patients were grouped into four categories: motor neurone disorders (MND; 39%), pulmonary disease (PULM; 25%, mainly chronic obstructive pulmonary disease), non-MND neuromuscular and chest wall disorders (NMCW; 21%) and the obesity hypoventilation syndrome (OHS; 15%)...
January 1, 2018: Chronic Respiratory Disease
Danai S Gkotsi, Jag Dhaliwal, Matthew Mw McLachlan, Keith R Mulholand, Rebecca Jm Goss
No abstract text is available yet for this article.
February 1, 2018: Current Opinion in Chemical Biology
Bikramjit Das, Venkataseshan Sundaram, William Tarnow-Mordi, Alpana Ghadge, Lakhbir Kaur Dhaliwal, Praveen Kumar
OBJECTIVES: To compare effect of placental transfusion by delayed cord clamping (DCC) or cord milking (CM) with early cord clamping (ECC) on a composite of mortality or abnormal neurological status at 40 weeks' post-menstrual age (PMA) and 24-30 months' chronological age in neonates of 30-33 weeks' gestation. STUDY DESIGN: Randomized, controlled trial. OUTCOMES: A composite of mortality or abnormal neurological status at 40 weeks PMA and survival free of neurodevelopmental abnormalities at 24-30 months' chronological age...
February 6, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
Peri H Fenwick, Khursheed Jeejeebhoy, Rupinder Dhaliwal, Dawna Royall, Paula Brauer, Angelo Tremblay, Doug Klein, David M Mutch
Metabolic syndrome (MetS) comprises a cluster of risk factors that includes central obesity, dyslipidemia, impaired glucose homeostasis and hypertension. Individuals with MetS have elevated risk of type 2 diabetes and cardiovascular disease; thus placing significant burdens on social and healthcare systems. Lifestyle interventions (comprised of diet, exercise or a combination of both) are routinely recommended as the first line of treatment for MetS. Only a proportion of people respond, and it has been assumed that psychological and social aspects primarily account for these differences...
February 5, 2018: Critical Reviews in Food Science and Nutrition
Aram S Modrek, Jod Prado, Devin Bready, Joravar Dhaliwal, Danielle Golub, Dimitris G Placantonakis
Gliomas are malignant primary tumors of the central nervous system. Their cell-of-origin is thought to be a neural progenitor or stem cell that acquires mutations leading to oncogenic transformation. Thanks to advances in human stem cell biology, it has become possible to derive human cell types that represent putative cells-of-origin in vitro and model the gliomagenesis process by systematically introducing genetic alterations in these human cells. Here, we present methods to derive human neural stem cells (NSCs) from human embryonic stem cells (hESCs)...
2018: Methods in Molecular Biology
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