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REVIEW
Kiarash Saleki, Parsa Alijanizadeh, Nima Javanmehr, Nima Rezaei
Neuropsychiatric disorders denote a broad range of illnesses involving neurology and psychiatry. These disorders include depressive disorders, anxiety, schizophrenia, bipolar disorder, attention deficit hyperactivity disorder, autism spectrum disorders, headaches, and epilepsy. In addition to their main neuropathology that lies in the central nervous system (CNS), lately, studies have highlighted the role of immunity and neuroinflammation in neuropsychiatric disorders. Toll-like receptors (TLRs) are innate receptors that act as a bridge between the innate and adaptive immune systems via adaptor proteins (e...
January 16, 2024: Medicinal Research Reviews
#22
JOURNAL ARTICLE
Suqi Cao, Zicheng Zhang, Lei Liu, Yin Li, Wei Li, Yunling Li, Dingfeng Wu
BACKGROUND: Observational studies have suggested the potential associations between atopic dermatitis (AD) and psychiatric disorders. However, the causal relationship between them remains uncertain. This study aimed to evaluate the potential bidirectional causal relationship between AD and psychiatric disorders, including autism spectrum disorder (ASD), major depressive disorder (MDD), attention deficit hyperactivity disorder (ADHD), bipolar disorder (BD), anorexia nervosa (AN), Tourette syndrome (TS), schizophrenia, and anxiety...
January 3, 2024: BMC Psychiatry
#23
REVIEW
Matteo Martino, Paola Magioncalda
How phenomenal experience and behavior are related to neural activity in physiology and psychopathology represents a fundamental question in neuroscience and psychiatry. The phenomenal-behavior patterns may be deconstructed into basic dimensions, i.e., psychomotricity, affectivity, and thought, which might have distinct neural correlates. This work provides a data overview on the relationship of these phenomenal-behavioral dimensions with brain activity across physiological and pathological conditions (including major depressive disorder, bipolar disorder, schizophrenia, attention-deficit/hyperactivity disorder, anxiety disorders, addictive disorders, Parkinson's disease, Tourette syndrome, Alzheimer's disease, and frontotemporal dementia)...
December 19, 2023: Molecular Psychiatry
#24
REVIEW
Tabeer Afzal, Justin Louis Hipolito, Laura Jin
Bipolar disorders (BP) are a class of psychiatric disorders with a complex symptom presentation. This systematic review aims to summarize literature pertaining to the misdiagnosis of pediatric BP using the DSM-IV and DSM-5 criteria, while emphasizing the negative impact that untreated BP has on life outcomes. This paper also attempts to outline and summarize available recommendations which may aid in improving diagnostic accuracy of pediatric BP. Scholars Portal Journals, PsychINFO, and MEDLINE databases were used to search articles until March 21, 2023...
December 18, 2023: Research on child and adolescent psychopathology
#25
JOURNAL ARTICLE
Oskar Hougaard Jefsen, Katrine Holde, John J McGrath, Veera Manikandan Rajagopal, Clara Albiñana, Bjarni Jóhann Vilhjálmsson, Jakob Grove, Esben Agerbo, Zeynep Yilmaz, Oleguer Plana-Ripoll, Trine Munk-Olsen, Ditte Demontis, Anders Børglum, Ole Mors, Cynthia M Bulik, Preben Bo Mortensen, Liselotte Vogdrup Petersen
BACKGROUND: Education is essential for socioeconomic security and long-term mental health, however mental disorders are often detrimental to the educational trajectory. Genetic correlations between mental disorders and educational attainment do not always align with corresponding phenotypic associations, implying heterogeneity in the genetic overlap. METHODS: We unraveled this heterogeneity by investigating associations between polygenic risk scores for six mental disorders and fine-grained school outcomes: school grades in language and mathematics in ninth grade and high school, as well as educational attainment by age 25, using nationwide-representative data from established cohorts (n = 79,489)...
December 5, 2023: Biological Psychiatry
#26
JOURNAL ARTICLE
Psychiatric Comorbidities and Schizophrenia in Youths With Attention-Deficit/Hyperactivity Disorder.
Soo Min Jeon, Dong Yun Lee, SangHun Cha, Jin-Won Kwon
IMPORTANCE: The association between attention-deficit/hyperactivity disorder (ADHD) and schizophrenia has received increased attention; however, evidence on the association between psychiatric comorbidities and subsequent schizophrenia in patients with ADHD is limited. OBJECTIVE: To investigate the risk of being diagnosed with schizophrenia in children and adolescents with ADHD considering the presence of psychiatric comorbidity. DESIGN, SETTING, AND PARTICIPANTS: This was a population-based, retrospective cohort study using the Health Insurance Review and Assessment claims database from January 1, 2007, to December 31, 2019...
November 1, 2023: JAMA Network Open
#27
JOURNAL ARTICLE
Hua Xue, Shuangjuan Liu, Li Zeng, Weihui Fan
BACKGROUND: This study aims to investigate the association between systemic lupus erythematosus (SLE) and the risk of seven psychiatric disorders through the application of Mendelian randomization (MR) analysis due to previous observational studies that have suggested a potential link between SLE and psychiatric disorders. METHODS: We collected genetic instruments for SLE from a genome-wide association study (GWAS) involving 23,210 individuals. Seven psychiatric traits were enrolled from the recent largest GWAS, including major depression disorder (MDD), generalized anxiety disorder (GAD), schizophrenia (SCZ), bipolar disorder (BID), autism spectrum disorder (ASD), attention deficit/hyperactivity disorder (ADHD), and insomnia...
November 24, 2023: Journal of Affective Disorders
#28
JOURNAL ARTICLE
Amy Shakeshaft, Joanna Martin, Charlotte A Dennison, Lucy Riglin, Cathryn M Lewis, Michael C O'Donovan, Anita Thapar
Anxiety and depression (emotional disorders) are familial and heritable, especially when onset is early. However, other cross-generational studies suggest transmission of youth emotional problems is explained by mainly environmental risks. We set out to test the contribution of parental non-transmitted genetic liability, as indexed by psychiatric/neurodevelopmental common polygenic liability, to youth emotional problems using a UK population-based cohort: the Millennium Cohort Study. European (N = 6328) and South Asian (N = 814) ancestries were included, as well as a subset with genomic data from both parents (European: N = 2809; South Asian: N = 254)...
November 21, 2023: Molecular Psychiatry
#29
JOURNAL ARTICLE
Yingwei Wang, Tao Yao, Yunlu Lin, Lili Ye, Shuting Li, Yu Gao, Jianming Wu
Although a large number of existing studies have confirmed that people with vitiligo are prone to mental disorders, these observational studies may be subject to confounding factors and reverse causality, so the true causal relationship is inconclusive. We conducted a bidirectional Mendelian randomization (MR) analysis to assess the causality between vitiligo and mental disorders, namely depression, anxiety, insomnia, schizophrenia, bipolar disorder, obsessive-compulsive disorder (OCD) and attention-deficit hyperactivity disorder (ADHD)...
November 17, 2023: Experimental Dermatology
#30
JOURNAL ARTICLE
Trine Munk-Olsen, Arianna Di Florio, Kathrine B Madsen, Clara Albiñana, Merete L Mægbæk, Veerle Bergink, Vibe G Frøkjær, Esben Agerbo, Bjarni J Vilhjálmsson, Thomas Werge, Merete Nordentoft, David M Hougaard, Anders D Børglum, Ole Mors, Preben Bo Mortensen, Xiaoqin Liu
It remains inconclusive whether postpartum depression (PPD) and depression with onset outside the postpartum period (MDD) are genetically distinct disorders. We aimed to investigate whether polygenic risk scores (PGSs) for major mental disorders differ between PPD cases and MDD cases in a nested case-control study of 50,057 women born from 1981 to 1997 in the iPSYCH2015 sample in Demark. We identified 333 women with first-onset postpartum depression (PPD group), who were matched with 993 women with first-onset depression diagnosed outside of postpartum (MDD group), and 999 female population controls...
November 13, 2023: Translational Psychiatry
#31
JOURNAL ARTICLE
Serkan Sayin
Dopamine (DA) at normal levels in the human body exhibits a high potential for maintaining a proper neuron network. However, their abnormalities in humans can bring out aggressive disorders such as Schizophrenia, hypertension, Tourette's syndrome, Alzheimer's disease, bipolar depression, Parkinson's disease, drug addiction and attention-deficit hyperactivity diseases. Hence, in this study, a bis-quinoline-substituted calix[4] arene carboxylic acid derivative ( Quin-Calix-CO2 H ) at cone conformation was developed as an effective fluorescent sensor for the detection of a catecholamine neurotransmitter (dopamine)...
November 8, 2023: Journal of Biomolecular Structure & Dynamics
#32
JOURNAL ARTICLE
Helena K Kim, Vanessa F Gonçalves, Muhammad I Husain, Daniel J Müller, Benoit H Mulsant, Gwyneth Zai, Stefan Kloiber
The endocannabinoid system (ECS) is implicated in multiple mental disorders. In this study, we explored DNA variations in the ECS across major depressive disorder (MDD), bipolar disorder, attention deficit hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and schizophrenia by performing a cross-disorder genome-wide association study (GWAS) meta-analysis. We obtained six datasets from the Psychiatric Genomics Consortium containing GWAS summary statistics from European cohorts (284,023 cases and 508,515 controls)...
October 30, 2023: Psychiatry Research
#33
JOURNAL ARTICLE
Yifan Yu, Lei Hou, Yutong Wu, Yuanyuan Yu, Xinhui Liu, Sijia Wu, Yina He, Yilei Ge, Yun Wei, Fengtong Qian, Qingxin Luo, Yue Feng, Xiaojing Cheng, Tiangui Yu, Hongkai Li, Fuzhong Xue
BACKGROUND: The timings of reproductive life events have been examined to be associated with various psychiatric disorders. However, studies have not considered the causal pathways from reproductive behaviors to different psychiatric disorders. This study aimed to investigate the nature of the relationships between five reproductive behaviors and twelve psychiatric disorders. METHODS: Firstly, we calculated genetic correlations between reproductive factors and psychiatric disorders...
November 2, 2023: BMC Psychiatry
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JOURNAL ARTICLE
Yulin Xiang, Jukun Song, Ying Liang, Jiaxin Sun, Zhijun Zheng
OBJECTIVES: This study was to investigate the causal relationship between temporomandibular disorders (TMD) and psychiatric disorders by Mendelian randomization (MR) analysis. MATERIALS AND METHODS: A two-sample bidirectional MR analysis was adopted to systematically explore the causal relationship between TMD and eight psychiatric traits, including anxiety disorder (AD), panic disorder (PD), major depressive disorder (MDD), neuroticism, attention deficit hyperactivity disorder (ADHD), autism spectrum disorder (ASD), bipolar disorder (BIP), and schizophrenia (SCZ)...
November 1, 2023: Clinical Oral Investigations
#35
REVIEW
Ronald Miguel Hernández, Jacqueline Cynthia Ponce-Meza, Miguel Ángel Saavedra-López, Walter Antonio Campos Ugaz, Roxana Monteza Chanduvi, Walter Campos Monteza
Objective: In recent years, researchers and neuroscientists have begun to use a variety of nonlinear techniques for analyzing neurophysiologic signals derived from fMRI, MEG, and EEG in order to describe the complex dynamical aspects of neural mechanisms. In this work, we first attempted to describe different algorithms to estimate neural complexity in a simple manner understandable for psychiatrists, psychologists, and neuroscientists. Then, we reviewed the findings of the brain complexity analysis in psychiatric disorders and their clinical implications...
October 2023: Iranian Journal of Psychiatry
#36
JOURNAL ARTICLE
Margaret G Guo, David L Reynolds, Cheen E Ang, Yingfei Liu, Yang Zhao, Laura K H Donohue, Zurab Siprashvili, Xue Yang, Yongjin Yoo, Smarajit Mondal, Audrey Hong, Jessica Kain, Lindsey Meservey, Tania Fabo, Ibtihal Elfaki, Laura N Kellman, Nathan S Abell, Yash Pershad, Vafa Bayat, Payam Etminani, Mark Holodniy, Daniel H Geschwind, Stephen B Montgomery, Laramie E Duncan, Alexander E Urban, Russ B Altman, Marius Wernig, Paul A Khavari
Noncoding variants of presumed regulatory function contribute to the heritability of neuropsychiatric disease. A total of 2,221 noncoding variants connected to risk for ten neuropsychiatric disorders, including autism spectrum disorder, attention deficit hyperactivity disorder, bipolar disorder, borderline personality disorder, major depression, generalized anxiety disorder, panic disorder, post-traumatic stress disorder, obsessive-compulsive disorder and schizophrenia, were studied in developing human neural cells...
November 2023: Nature Genetics
#37
REVIEW
Michele De Prisco, Vincenzo Oliva, Giovanna Fico, Joaquim Radua, Iria Grande, Natalia Roberto, Gerard Anmella, Diego Hidalgo-Mazzei, Michele Fornaro, Andrea de Bartolomeis, Alessandro Serretti, Eduard Vieta, Andrea Murru
People with bipolar disorder (BD) often present emotion dysregulation (ED), a pattern of emotional expression interfering with goal-directed behavior. ED is a transdiagnostic construct, and it is unclear whether it manifests itself similarly in other conditions, such as major depressive disorder (MDD) or borderline personality disorder (BPD), or has specific features in BD. The present systematic review and meta-analysis explored ED and adopted emotion regulation (ER) strategies in BD compared with other psychiatric conditions...
October 16, 2023: Psychological Medicine
#38
JOURNAL ARTICLE
Xiaohui Sui, Tingting Liu, Yi Liang, Baoqing Zhang
BACKGROUND: Previous researches have demonstrated a connection between psychiatric disorders and cardiovascular diseases (CVDs), but the cause-and-effect relationship is still unclear. To that goal, the mendelian randomization (MR) method was used to study the causal link between psychiatric disorders and CVDs. METHODS: Genome-wide association studies (GWAS) data were collected for four CVDs, including coronary artery disease (n = 547,261), atrial fibrillation (n = 537,409), heart failure (n = 977,323) and ischemic stroke (n = 440,328)...
October 2023: Heliyon
#39
JOURNAL ARTICLE
Shweta Patel, Suraiya Silvi, Saral Desai, Fayaz Rahman, Nishitha Depa, Sarah Hanif, Syeda Rizvi, Ya-Ching Hsieh, Preeti Malik, Urvish Patel, Zeeshan Mansuri, Rana Prathap Mercy, Kapil Aedma, Tapan Parikh
Objective: To analyze the safety and efficacy of repetitive transcranial magnetic stimulation (rTMS) for major depressive disorder, schizophrenia, and obsessive-compulsive disorder (OCD) via umbrella meta-analysis. Data Sources: Meta-analysis studies were searched in PubMed from inception to May 2021 using the keywords anxiety , depression , ADHD , schizophrenia , mood disorder , OCD , psychiatric disorders , GAD , bipolar disorders , ASD , PTSD , transcranial magnetic stimulation , transcranial , magnetic , stimulation ...
September 26, 2023: Primary Care Companion to CNS Disorders
#40
JOURNAL ARTICLE
Anna R Docherty, Niamh Mullins, Allison E Ashley-Koch, Xuejun Qin, Jonathan R I Coleman, Andrey Shabalin, JooEun Kang, Balasz Murnyak, Frank Wendt, Mark Adams, Adrian I Campos, Emily DiBlasi, Janice M Fullerton, Henry R Kranzler, Amanda V Bakian, Eric T Monson, Miguel E Rentería, Consuelo Walss-Bass, Ole A Andreassen, Chittaranjan Behera, Cynthia M Bulik, Howard J Edenberg, Ronald C Kessler, J John Mann, John I Nurnberger, Giorgio Pistis, Fabian Streit, Robert J Ursano, Renato Polimanti, Michelle Dennis, Melanie Garrett, Lauren Hair, Philip Harvey, Elizabeth R Hauser, Michael A Hauser, Jennifer Huffman, Daniel Jacobson, Ravi Madduri, Benjamin McMahon, David W Oslin, Jodie Trafton, Swapnil Awasthi, Wade H Berrettini, Martin Bohus, Xiao Chang, Hsi-Chung Chen, Wei J Chen, Erik D Christensen, Scott Crow, Philibert Duriez, Alexis C Edwards, Fernando Fernández-Aranda, Hanga Galfalvy, Michael Gandal, Philip Gorwood, Yiran Guo, Jonathan D Hafferty, Hakon Hakonarson, Katherine A Halmi, Akitoyo Hishimoto, Sonia Jain, Stéphane Jamain, Susana Jiménez-Murcia, Craig Johnson, Allan S Kaplan, Walter H Kaye, Pamela K Keel, James L Kennedy, Minsoo Kim, Kelly L Klump, Daniel F Levey, Dong Li, Shih-Cheng Liao, Klaus Lieb, Lisa Lilenfeld, Christian R Marshall, James E Mitchell, Satoshi Okazaki, Ikuo Otsuka, Dalila Pinto, Abigail Powers, Nicolas Ramoz, Stephan Ripke, Stefan Roepke, Vsevolod Rozanov, Stephen W Scherer, Christian Schmahl, Marcus Sokolowski, Anna Starnawska, Michael Strober, Mei-Hsin Su, Laura M Thornton, Janet Treasure, Erin B Ware, Hunna J Watson, Stephanie H Witt, D Blake Woodside, Zeynep Yilmaz, Lea Zillich, Rolf Adolfsson, Ingrid Agartz, Martin Alda, Lars Alfredsson, Vivek Appadurai, María Soler Artigas, Sandra Van der Auwera, M Helena Azevedo, Nicholas Bass, Claiton H D Bau, Bernhard T Baune, Frank Bellivier, Klaus Berger, Joanna M Biernacka, Tim B Bigdeli, Elisabeth B Binder, Michael Boehnke, Marco P Boks, David L Braff, Richard Bryant, Monika Budde, Enda M Byrne, Wiepke Cahn, Enrique Castelao, Jorge A Cervilla, Boris Chaumette, Aiden Corvin, Nicholas Craddock, Srdjan Djurovic, Jerome C Foo, Andreas J Forstner, Mark Frye, Justine M Gatt, Ina Giegling, Hans J Grabe, Melissa J Green, Eugenio H Grevet, Maria Grigoroiu-Serbanescu, Blanca Gutierrez, Jose Guzman-Parra, Marian L Hamshere, Annette M Hartmann, Joanna Hauser, Stefanie Heilmann-Heimbach, Per Hoffmann, Marcus Ising, Ian Jones, Lisa A Jones, Lina Jonsson, René S Kahn, John R Kelsoe, Kenneth S Kendler, Stefan Kloiber, Karestan C Koenen, Manolis Kogevinas, Marie-Odile Krebs, Mikael Landén, Marion Leboyer, Phil H Lee, Douglas F Levinson, Calwing Liao, Jolanta Lissowska, Fermin Mayoral, Susan L McElroy, Patrick McGrath, Peter McGuffin, Andrew McQuillin, Divya Mehta, Ingrid Melle, Philip B Mitchell, Esther Molina, Gunnar Morken, Caroline Nievergelt, Markus M Nöthen, Michael C O'Donovan, Roel A Ophoff, Michael J Owen, Carlos Pato, Michele T Pato, Brenda W J H Penninx, James B Potash, Robert A Power, Martin Preisig, Digby Quested, Josep Antoni Ramos-Quiroga, Andreas Reif, Marta Ribasés, Vanesa Richarte, Marcella Rietschel, Margarita Rivera, Andrea Roberts, Gloria Roberts, Guy A Rouleau, Diego L Rovaris, Alan R Sanders, Peter R Schofield, Thomas G Schulze, Laura J Scott, Alessandro Serretti, Jianxin Shi, Lea Sirignano, Pamela Sklar, Olav B Smeland, Jordan W Smoller, Edmund J S Sonuga-Barke, Maciej Trzaskowski, Ming T Tsuang, Gustavo Turecki, Laura Vilar-Ribó, John B Vincent, Henry Völzke, James T R Walters, Cynthia Shannon Weickert, Thomas W Weickert, Myrna M Weissman, Leanne M Williams, Naomi R Wray, Clement C Zai, Esben Agerbo, Anders D Børglum, Gerome Breen, Ditte Demontis, Annette Erlangsen, Joel Gelernter, Stephen J Glatt, David M Hougaard, Hai-Gwo Hwu, Po-Hsiu Kuo, Cathryn M Lewis, Qingqin S Li, Chih-Min Liu, Nicholas G Martin, Andrew M McIntosh, Sarah E Medland, Ole Mors, Merete Nordentoft, Catherine M Olsen, David Porteous, Daniel J Smith, Eli A Stahl, Murray B Stein, Danuta Wasserman, Thomas Werge, David C Whiteman, Virginia Willour, Hilary Coon, Jean C Beckham, Nathan A Kimbrel, Douglas M Ruderfer
OBJECTIVE: Suicidal behavior is heritable and is a major cause of death worldwide. Two large-scale genome-wide association studies (GWASs) recently discovered and cross-validated genome-wide significant (GWS) loci for suicide attempt (SA). The present study leveraged the genetic cohorts from both studies to conduct the largest GWAS meta-analysis of SA to date. Multi-ancestry and admixture-specific meta-analyses were conducted within groups of significant African, East Asian, and European ancestry admixtures...
October 1, 2023: American Journal of Psychiatry
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