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circulating Monocyte cells

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https://www.readbyqxmd.com/read/29684027/chronic-calcitriol-supplementation-improves-the-inflammatory-profiles-of-circulating-monocytes-and-the-associated-intestinal-adipose-tissue-alteration-in-a-diet-induced-steatohepatitis-rat-model
#1
Yen-Bo Su, Tzu-Hao Li, Chia-Chang Huang, Hung-Cheng Tsai, Shiang-Fen Huang, Yun-Cheng Hsieh, Ying-Ying Yang, Yi-Hsiang Huang, Ming-Chih Hou, Han-Chieh Lin
Vitamin D deficiency and up-regulated TNFα-related signals are reported to be involved in abnormalities including intestinal hyper-permeability, bacterial translocation, systemic/portal endotoxemia, intestinal/adipose tissue/hepatic inflammation, and hepatic steatosis in nonalcoholic steatohepatitis (NASH). This study aims to explore the molecular mechanisms and effects of chronic calcitriol [1,25-(OH)2D3, hormonal form of vitamin D] on gut-adipose tissue-liver axis abnormalities using a high-fat diet (HFD)-fed rat model of NASH...
2018: PloS One
https://www.readbyqxmd.com/read/29683844/circulating-inflammatory-monocytes-contribute-to-impaired-influenza-vaccine-responses-in-hiv-infected-participants
#2
Varghese K George, Suresh Pallikkuth, Rajendra Pahwa, Lesley de Armas, Stefano Rinaldi, Li Pan, Savita Pahwa
OBJECTIVE: Antibody responses are often impaired in old age and in HIV+ infection despite virologic control with antiretroviral therapy but innate immunologic determinants are not well understood. DESIGN: Monocytes and natural killer cells were examined for relationships to age, HIV infection and influenza vaccine responses. METHODS: Virologically suppressed HIV+ (n = 139) and HIV- (n = 137) participants classified by age as young (18-39 years), middle-aged (40-59 years) and old (≥60 years) were evaluated preinfluenza and postinfluenza vaccination...
April 19, 2018: AIDS
https://www.readbyqxmd.com/read/29681407/circulating-metabolites-of-strawberry-mediate-reductions-in-vascular-inflammation-and-endothelial-dysfunction-in-db-db-mice
#3
Chrissa Petersen, Divya Bharat, Brett Ronald Cutler, Samira Gholami, Christopher Denetso, Jennifer Ellen Mueller, Jae Min Cho, Ji-Seok Kim, J David Symons, Pon Velayutham Anandh Babu
BACKGROUND: Cardiovascular disease is 2-4-fold more prevalent in patients with diabetes. Human studies support the cardiovascular benefits of strawberry consumption but the effects of strawberry on diabetic vasculature are unknown. We tested the hypothesis that dietary strawberry supplementation attenuates vascular inflammation and dysfunction in diabetic mice. METHODS: Seven-week-old diabetic db/db mice that consumed standard diet (db/db) or diet supplemented with 2...
April 12, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29677388/engulfment-of-hb-activated-platelets-differentiates-monocytes-into-pro-inflammatory-macrophages-in-pnh-patients
#4
Rashi Singhal, Sheetal Chawla, Harish Batra, Sameer Gupta, Amrita Ojha, Deepak K Rathore, Tulika Seth, Prasenjit Guchhait
The distinct response shown by different phenotypes of macrophages and monocytes under various clinical conditions have put the heterogeneity of these cells into focus of investigation for several diseases. Recently we have described that after engulfing Hb-activated platelets, classical monocytes differentiated into pro-inflammatory phenotypes, which were abundant in the circulation of PNH and SCD patients. Our current study shows that upon engulfment of Hb-activated platelets, monocytes differentiate into M1-macrophages under M1-polarization stimulus (GM-CSF, IFN-γ+LPS)...
April 20, 2018: European Journal of Immunology
https://www.readbyqxmd.com/read/29675019/enhanced-akt-phosphorylation-of-circulating-b-cells-in-patients-with-activated-pi3k%C3%AE-syndrome
#5
Takaki Asano, Satoshi Okada, Miyuki Tsumura, Tzu-Wen Yeh, Kanako Mitsui-Sekinaka, Yuki Tsujita, Youjiro Ichinose, Akira Shimada, Kunio Hashimoto, Taizo Wada, Kohsuke Imai, Osamu Ohara, Tomohiro Morio, Shigeaki Nonoyama, Masao Kobayashi
Activated PI3Kδ syndrome (APDS) is a primary immunodeficiency characterized by recurrent respiratory tract infections, lymphoproliferation, and defective IgG production. Heterozygous mutations in PIK3CD, PIK3R1 , or PTEN , which are related to the hyperactive phosphoinositide 3-kinase (PI3K) signaling, were recently presented to cause APDS1 or APDS2 (APDSs), or APDS-like (APDS-L) disorder. In this study, we examined the AKT phosphorylation of peripheral blood lymphocytes and monocytes in patients with APDSs and APDS-L by using flow cytometry...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29673796/cigarette-smoke-extract-interferes-with-placenta-macrophage-functions-a-new-mechanism-to-compromise-placenta-functions
#6
Rym Belhareth, Soraya Mezouar, Amira Ben Amara, Céline Chartier, Eya Ben Azzouz, Eric Chabrière, Mohamed Amri, Jean-Louis Mege
The success of pregnancy depends on the maternal immune system's ability to promote tolerance and host defense. This equilibrium is compromised in inflammatory and infectious impairment of placenta. Smoking during pregnancy exposes the fetus to severe complications which might result from an alteration in placenta macrophages (pMφ) functions. In this study, we assessed the effect of cigarette smoke extract (CSE) on the functions of third trimester pMφs.CSE inhibited particles uptake and the formation of multinucleated giant cells, a recently reported property of pMφs based on their ability to fuse in vitro...
April 16, 2018: Reproductive Toxicology
https://www.readbyqxmd.com/read/29672927/interleukin-33-contributes-to-ilc2-activation-and-early-inflammation-associated-lung-injury-during-abdominal-sepsis
#7
Hui Xu, Jing Xu, Li Xu, Shuqing Jin, Heth R Turnquist, Rosemary Hoffman, Patricia Loughran, Timothy R Billiar, Meihong Deng
Sepsis is defined as infection with organ dysfunction due to a dysregulated immune response. The lung is one of the most vulnerable organs at the onset of sepsis. Interleukin-33 (IL-33) can be released by injured epithelial and endothelial cells in the lung and regulate immune activation and infiltration. Therefore, we postulated that IL-33 would contribute to the immune response in the lung during sepsis. Using the cecal ligation and puncture (CLP) sepsis model, we show here that IL-33 contributes significantly to both sepsis-induced inflammation in the lung and systemic inflammatory response in the early phase of sepsis...
April 19, 2018: Immunology and Cell Biology
https://www.readbyqxmd.com/read/29670115/clinicopathological-and-prognostic-significance-of-high-circulating-lymphocyte-ratio-in-patients-receiving-neoadjuvant-chemotherapy-for-advanced-gastric-cancer
#8
Yang Li, Yao Wei, Qi He, Xulin Wang, Chaogang Fan, Guoli Li
This study was designed to investigate the prognostic value of circulating blood cell counts and subsets for patients with advanced gastric cancer (AGC) treated with neoadjuvant chemotherapy (NAC) and the factors determining pathological complete response (pCR). In 112 patients with AGC, we retrospectively examined the ratios of lymphocyte, monocyte, and neutrophil during and after NAC before surgery, and the percentages of CD3+, CD3+ CD4+, CD3+ CD8+ and CD4+/CD8+ lymphocytes as well. We also investigated their associations with the pCR rate and overall survival (OS)...
April 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29666112/increased-erythrophagocytosis-induces-ferroptosis-in-red-pulp-macrophages-in-a-mouse-model-of-transfusion
#9
Lyla A Youssef, Abdelhadi Rebbaa, Sergey Pampou, Stuart P Weisberg, Brent R Stockwell, Eldad A Hod, Steven L Spitalnik
Macrophages play important roles in recycling iron derived from the clearance of red blood cells (RBCs). They are also a critically important component of host defense, protecting against invading pathogens. However, the effects on macrophage biology of acutely ingesting large numbers of RBCs are not completely understood. To investigate this issue, we used a mouse model of RBC transfusion and clearance, which mimics the clinical setting. In this model, transfusions of refrigerator storage-damaged (i.e., "old") RBCs led to increased erythrophagocytosis by splenic red pulp macrophages (RPMs)...
April 17, 2018: Blood
https://www.readbyqxmd.com/read/29665135/hepatocellular-carcinoma-is-associated-with-gut-microbiota-profile-and-inflammation-in-non-alcoholic-fatty-liver-disease
#10
Francesca Romana Ponziani, Sherrie Bhoori, Chiara Castelli, Lorenza Putignani, Licia Rivoltini, Federica Del Chierico, Maurizio Sanguinetti, Daniele Morelli, Francesco Paroni Sterbini, Valentina Petito, Sofia Reddel, Riccardo Calvani, Chiara Camisaschi, Anna Picca, Alessandra Tuccitto, Antonio Gasbarrini, Maurizio Pompili, Vincenzo Mazzaferro
The gut-liver axis plays a pivotal role in the pathogenesis of non-alcoholic fatty liver disease (NAFLD), which is the third cause of hepatocellular carcinoma (HCC) worldwide. However, the link between gut microbiota and hepatocarcinogenesis remains to be clarified. The aim of this study is to explore what features of the gut microbiota are associated with HCC in cirrhotic patients with NAFLD. A consecutive series of patients with NAFLD-related cirrhosis and HCC (group 1: 21 patients), NAFLD-related cirrhosis without HCC (group 2: 20 patients) and healthy controls (group 3: 20 patients) was studied for gut microbiota profile, intestinal permeability, inflammatory status and circulating mononuclear cells...
April 17, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29626088/granulocytes-are-unresponsive-to-il-6-due-to-an-absence-of-gp130
#11
Andrew N Wilkinson, Kate H Gartlan, Greg Kelly, Luke D Samson, Stuart D Olver, Judy Avery, Nienke Zomerdijk, Siok-Keen Tey, Jason S Lee, Slavica Vuckovic, Geoffrey R Hill
IL-6 mediates broad physiological and pathological effects through its receptor signal transducing unit gp130. Due to the reportedly wide cellular expression of gp130, IL-6 is thought to signal ubiquitously via gp130 complex formation with membrane-bound IL-6Rα or soluble IL-6Rα. gp130 signaling primarily induces p-STAT3 and p-STAT1. In contrast to the previous dogma, we show in this article that circulating mouse and human granulocytes are unable to induce p-STAT3 or p-STAT1 after stimulation with IL-6 or an IL-6/soluble IL-6R complex...
April 6, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29621877/the-prognostic-role-of-circulating-epstein-barr-virus-dna-copy-number-in-angioimmunoblastic-t-cell-lymphoma-treated-with-dose-adjusted-epoch
#12
Jin-Hua Liang, Luo Lu, Hua-Yuan Zhu, Wang Li, Lei Fan, Jian-Yong Li, Wei Xu
Purpose: Determine the frequency and prognostic value of circulating Epstein-Barr virus (EBV) DNA copy number in angioimmunoblastic T-cell lymphoma (AITL) patients who were treated with dose-adjusted etoposide, prednisone, vincristine, cyclophosphamide and doxorubicin (DA-EPOCH) regimens. Materials and Methods: Sixty newly-diagnosed AITL patients were retrospectively enrolled in the present study. All patients were treated with DA-EPOCH regimen. Results: Twenty-two subjects (36...
April 2, 2018: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/29617574/circulating-and-tumor-myeloid-derived-suppressor-cells-in-resectable-non-small-cell-lung-cancer
#13
Yoshikane Yamauchi, Seyer Safi, Carolin Blattner, Anchana Rathinasamy, Ludmila Umansky, Simone Juenger, Arne Warth, Martin Eichhorn, Thomas Muley, Felix J F Herth, Hendrik Dienemann, Michael Platten, Philipp Beckhove, Jochen Utikal, Hans Hoffmann, Viktor Umansky
Rationale Myeloid-derived suppressor cell (MDSC) expansion has been found to play a role in disease progression in cancer patients. However, the characteristics of MDSCs in lung cancer are poorly understood. Objectives We prospectively investigated MDSCs and inflammatory factors in tumor and peripheral blood samples from patients with resectable non-small cell lung cancer (NSCLC) and studied their correlations with the disease prognosis. Methods A complex analysis of MDSC subsets and inflammatory mediators was performed using flow cytometry and a Bio-Plex assay...
April 4, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29615814/the-impact-of-circulating-preeclampsia-associated-extracellular-vesicles-on-the-migratory-activity-and-phenotype-of-thp-1-monocytic-cells
#14
Árpád Ferenc Kovács, Orsolya Láng, Lilla Turiák, András Ács, László Kőhidai, Nóra Fekete, Bálint Alasztics, Tamás Mészáros, Edit Irén Buzás, János Rigó, Éva Pállinger
Intercellular communication via extracellular vesicles (EVs) and their target cells, especially immune cells, results in functional and phenotype changes that consequently may play a significant role in various physiological states and the pathogenesis of immune-mediated disorders. Monocytes are the most prominent environment-sensing immune cells in circulation, skilled to shape their microenvironments via cytokine secretion and further differentiation. Both the circulating monocyte subset distribution and the blood plasma EV pattern are characteristic for preeclampsia, a pregnancy induced immune-mediated hypertensive disorder...
April 3, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29615676/silent-infection-of-human-dendritic-cells-by-african-and-asian-strains-of-zika-virus
#15
Nathalie J Vielle, Beatrice Zumkehr, Obdulio García-Nicolás, Fabian Blank, Miloš Stojanov, Didier Musso, David Baud, Artur Summerfield, Marco P Alves
While Zika virus (ZIKV) circulated for decades (African lineage strains) without report of outbreaks and severe complications, its emergence in French Polynesia and subsequently in the Americas (Asian lineage strains) was associated with description of severe neurological defects in newborns/neonates and adults. With the aim to identify virus lineage-dependent factors, we compared cell susceptibility, virus replication, cell death and innate immune responses following infection with two African and three contemporary Asian lineage strains of ZIKV...
April 3, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29614988/altered-monocyte-differentiation-and-macrophage-polarization-patterns-in-patients-with-breast-cancer
#16
Chih-Hsing Hung, Fang-Ming Chen, Yi-Ching Lin, Mei-Lan Tsai, Shih-Ling Wang, Yen-Chun Chen, Yi-Ting Chen, Ming-Feng Hou
BACKGROUND: Macrophage heterogeneity is the main feature of the tumour microenvironment. Breast cancer is one of the most life-threatening cancers. However, macrophage polarization patterns in different tumour stages and the importance of its relationship to human epidermal growth factor receptor 2 (HER2) in breast cancer remains highly unclear. The present study investigated the patterns of monocyte differentiation and macrophage polarization in breast cancer. METHODS: Patients with breast cancer (n = 48) and healthy controls (n = 39) were prospectively recruited...
April 3, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29611111/caspase-1-associated-immune-activation-in-an-accelerated-siv-infected-rhesus-macaque-model
#17
Alison C Kearns, Jake A Robinson, Masoud Shekarabi, Fengming Liu, Xuebin Qin, Tricia H Burdo
In the antiretroviral therapy (ART) era, chronic HIV infection is primarily associated with chronic inflammation driving comorbidities such as cardiovascular disease and neurocognitive impairment. Caspase-1 activation in leukocytes has been documented in HIV infection; however, whether caspase-1 activation and the downstream pro-inflammatory cytokines interleukin-1beta (IL-1β) and interleukin-18 (IL-18) contribute to chronic inflammation in HIV comorbidities remains undetermined. The relationship between the caspase-1 cascade and persistent inflammation in HIV has not been investigated...
April 2, 2018: Journal of Neurovirology
https://www.readbyqxmd.com/read/29606341/myeloid-derived-suppressors-cells-mdsc-correlate-with-clinicopathologic-factors-and-pathologic-complete-response-pcr-in-patients-with-urothelial-carcinoma-uc-undergoing-cystectomy
#18
REVIEW
Moshe C Ornstein, Claudia Marcela Diaz-Montero, Patricia Rayman, Paul Elson, Samuel Haywood, James H Finke, Jin S Kim, Paul G Pavicic, Marcelo Lamenza, Sarah Devonshire, Priscilla Dann, Kim Schach, Andrew Stephenson, Steven Campbell, Hamid Emamekhoo, Marc S Ernstoff, Christopher J Hoimes, Timothy D Gilligan, Brian I Rini, Jorge A Garcia, Petros Grivas
BACKGROUND: Myeloid derived suppressor cells (MDSC) are heterogeneous immunosuppressive cells with potential predictive and prognostic roles in cancer. The association between MDSC, clinicopathologic factors, and pathologic response in patients with bladder urothelial carcinoma (UC) was explored. METHODS: Peripheral blood or tissue were collected from patients with UC undergoing definitive surgery. MDSCs levels were measured in peripheral blood mononuclear cells and fresh tumor tissue...
March 29, 2018: Urologic Oncology
https://www.readbyqxmd.com/read/29599135/par2-protease-activated-receptor-2-deficiency-attenuates-atherosclerosis-in-mice
#19
Shannon M Jones, Adrien Mann, Kelsey Conrad, Keith Saum, David E Hall, Lisa M McKinney, Nathan Robbins, Joel Thompson, Abigail D Peairs, Eric Camerer, Katey J Rayner, Michael Tranter, Nigel Mackman, A Phillip Owens
OBJECTIVE: PAR2 (protease-activated receptor 2)-dependent signaling results in augmented inflammation and has been implicated in the pathogenesis of several autoimmune conditions. The objective of this study was to determine the effect of PAR2 deficiency on the development of atherosclerosis. APPROACH AND RESULTS: PAR2 mRNA and protein expression is increased in human carotid artery and mouse aortic arch atheroma versus control carotid and aortic arch arteries, respectively...
March 29, 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29598931/tarc-expression-in-the-circulation-and-cutaneous-granulomas-correlates-with-disease-severity-and-indicates-th2-mediated-progression-in-patients-with-sarcoidosis
#20
Chuyen Thi Hong Nguyen, Naotomo Kambe, Ikuko Ueda-Hayakawa, Izumi Kishimoto, Nhung Thi My Ly, Kana Mizuno, Hiroyuki Okamoto
BACKGROUND: Sarcoidosis is a systemic disorder characterized by the accumulation of lymphocytes and monocyte/macrophage lineage cells that results in the formation of non-caseating granulomas. Thymus- and activation-regulated chemokine (TARC)/CCL17 is an important chemokine in the amplification of Th2 responses, which are achieved by recruiting CCR4-expressing CD4+ T lymphocytes. TARC concentrations are known to increase in the serum of sarcoidosis patients; however, its role in the assessment of severity and prognosis of sarcoidosis remains unknown...
March 26, 2018: Allergology International: Official Journal of the Japanese Society of Allergology
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