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circulating Monocyte cells

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https://www.readbyqxmd.com/read/29467653/the-antioxidant-activity-of-pistachios-reduces-cardiac-tissue-injury-of-acute-ischemia-reperfusion-i-r-in-diabetic-streptozotocin-stz-induced-hyperglycaemic-rats
#1
Rosanna Di Paola, Roberta Fusco, Enrico Gugliandolo, Ramona D'Amico, Michela Campolo, Saverio Latteri, Arianna Carughi, Giuseppina Mandalari, Salvatore Cuzzocrea
Diabetes mellitus is an important risk factor for the development of heart pathology. Myocardial infarction is the cause of death occurring after prolonged ischemia of the coronary arteries. Restoration of blood flow is the first intervention against heart attack, although the process of restoring blood flow to the ischemic myocardium could cause additional injury. This phenomenon, termed myocardial ischemia-reperfusion (MI-R) injury, is characterized by the formation of oxygen radicals. Pistachios have significant glucose- and insulin-lowering effects and can improve the inflammatory contest by downregulating both the expression and the circulating levels of several metabolic risk markers...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29465348/increased-circulating-cd14brightcd16-intermediate-monocytes-are-regulated-by-tnf-%C3%AE-and-il-6-axis-in-accordance-with-disease-activity-in-patients-with-rheumatoid-arthritis
#2
Masako Tsukamoto, Katsuya Suzuki, Noriyuki Seta, Tsutomi Takeuchi
OBJECTIVES: Although circulating CD14brightCD16+ monocyte subsets are increased in inflammatory disease, the pathogenesis of the increase in the inflammatory condition of the cells is still unclear and the relationship to cytokines is unknown particularly in rheumatoid arthritis (RA). The purpose of this study was to investigate the influence anti-cytokine treatment has on CD14brightCD16+ monocytes in patients with RA. METHODS: Thirty-two RA patients and 14 healthy volunteers (HV) were enrolled in this study...
January 31, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29462174/exposure-to-1-8-ghz-electromagnetic-fields-affects-morphology-dna-related-raman-spectra-and-mitochondrial-functions-in-human-lympho-monocytes
#3
M Lasalvia, R Scrima, G Perna, C Piccoli, N Capitanio, P F Biagi, L Schiavulli, T Ligonzo, M Centra, G Casamassima, A Ermini, V Capozzi
Blood is a fluid connective tissue of human body, where it plays vital functions for the nutrition, defense and well-being of the organism. When circulating in peripheral districts, it is exposed to some physical stresses coming from outside the human body, as electromagnetic fields (EMFs) which can cross the skin. Such fields may interact with biomolecules possibly inducing non thermal-mediated biological effects at the cellular level. In this study, the occurrence of biochemical/biological modifications in human peripheral blood lympho-monocytes exposed in a reverberation chamber for times ranging from 1 to 20 h to EMFs at 1...
2018: PloS One
https://www.readbyqxmd.com/read/29453607/semaphorin-7a-in-circulating-regulatory-t-cells-is-increased-in-autosomal-dominant-polycystic-kidney-disease-and-decreases-with-tolvaptan-treatment
#4
Yashang Lee, Katrina Lehmann Blount, Feng Dai, Siobhan Thompson, Jonathan Kaufman Scher, Sherrie Bitterman, Madeline Droher, Erica L Herzog, Gilbert Moeckel, Anil Karihaloo, Neera K Dahl
BACKGROUND: Semaphorin 7A (SEMA7A) is an immunomodulating protein implicated in lung and liver fibrosis. In autosomal-dominant polycystic kidney disease (ADPKD), the progressive expansion of renal cysts, inflammation, and subsequent renal fibrosis leads to end-stage renal disease (ESRD). SEMA7A may play a role in renal fibrosis and in ADPKD. METHODS: We evaluated Sema7a in a mouse model of renal fibrosis and determined the expression of SEMA7A in human ADPKD kidney...
February 16, 2018: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/29449276/immune-evasion-via-pd-1-pd-l1-on-nk-cells-and-monocyte-macrophages-is-more-prominent-in-hodgkin-lymphoma-than-dlbcl
#5
Frank Vari, David Arpon, Colm Keane, Mark S Hertzberg, Dipti Talaulikar, Sanjiv Jain, Qingyan Cui, Erica Han, Josh Tobin, Robert Bird, Donna Cross, Annette Hernandez, Clare Gould, Simone Birch, Maher K Gandhi
Much focus has been on the interaction of PD-L1 on malignant B-cells with PD-1 on effector T-cells in inhibiting anti-lymphoma immunity. We sought to establish the contribution of NK-cells and inhibitory CD163+ monocytes/macrophages in Hodgkin Lymphoma (cHL) and Diffuse Large B-cell Lymphoma (DLBCL). Levels of PD-1 on NK-cells were elevated in cHL relative to DLBCL. Notably, CD3- CD56hi CD16-ve NK-cells had substantially higher PD-1 expression relative to CD3- CD56dim CD16+ cells, and were expanded in blood and tissue, more marked in cHL than DLBCL patients...
February 15, 2018: Blood
https://www.readbyqxmd.com/read/29445379/contribution-of-regulatory-t-cells-in-nucleotide-binding-oligomerization-domain-2-response-to-influenza-virus-infection
#6
Benoit Egarnes, Jean Gosselin
Influenza A virus (IAV) is recognized to cause severe pulmonary illnesses in humans, particularly in elderly and children. One of the features associated with IAV infection is an excessive lung inflammation due to an uncontrolled immune response. The nucleotide-binding oligomerization domain 2 (NOD2) receptor is known to recognize ssRNA viruses such as IAV, but its role in the inflammatory process during viral infections remains to be clarified. In a previous report, we have shown that activation of NOD2 with muramyl dipeptide (MDP) significantly reduces both viral loads and lung inflammation and also improves pulmonary function during IAV infection...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29437578/tissue-factor-an-essential-mediator-of-hemostasis-and-trigger-of-thrombosis
#7
REVIEW
Steven P Grover, Nigel Mackman
Tissue factor (TF) is the high-affinity receptor and cofactor for FVII/VIIa. The TF-FVIIa complex is the primary initiator of blood coagulation and plays an essential role in hemostasis. TF is expressed on perivascular and epithelial cells at organ and body surfaces where it forms a hemostatic barrier. TF also provides additional hemostatic protection to vital organs, such as the brain, lung, and heart. Under pathological conditions, TF can trigger both arterial and venous thrombosis. For instance, atherosclerosis plaques contain high levels of TF on macrophage foam cells and microvesicles that drives thrombus formation after plaque rupture...
February 8, 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29433873/impact-of-repeated-abdominal-surgery-on-wound-healing-and-myeloid-cell-dynamics
#8
Gunes Esendagli, Digdem Yoyen-Ermis, Emil Guseinov, Cigdem Aras, Cisel Aydin, Aysegul Uner, Erhan Hamaloglu, Derya Karakoc
BACKGROUND: Even though wound dehiscence is a surgical complication, under certain medical conditions, repetition of the laparotomy (LT) (relaparotomy) can become inevitable. In addition to the risks associated with this surgical operation, relaparotomy can interfere with the tissue healing and contribute to the development of chronic wounds. METHODS: In an experimental relaparotomy wounding model, this study investigated the impact of repeated surgery on wound healing and on the immune cells of myeloid origin...
March 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29433150/cx3cr1-cx3cl1-axis-mediates-platelet-leukocyte-adhesion-to-arterial-endothelium-in-younger-patients-with-a-history-of-idiopathic-deep-vein-thrombosis
#9
Elena Furio, Maria Jose García-Fuster, Josep Redon, Patrice Marques, Rebeca Ortega, Maria Jesus Sanz, Laura Piqueras
Mechanisms linking deep vein thrombosis (DVT) and subclinical atherosclerosis and risk of cardiovascular events are poorly understood. The aim of this study was to investigate the potential impact of CX3CR1/CX3CL1 axis in DVT-associated endothelial dysfunction. The study included 22 patients (age: 37.5 ± 8.2 years) with a history of idiopathic DVT and without known cardiovascular risk factors and 23 aged-matched control subjects (age: 34 ± 7.8 years). Flow cytometry was used to evaluate peripheral markers of platelet activation, leukocyte immunophenotypes and CX3CR1/CX3CL1 expression in both groups...
February 12, 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29428948/ratio-of-immune-response-to-tumor-burden-predicts-survival-via-regulating-functions-of-lymphocytes-and-monocytes-in-diffuse-large-b-cell-lymphoma
#10
Hongfei Ji, Xingjian Niu, Lei Yin, Yiran Wang, Lan Huang, Qijia Xuan, Liru Li, Han Zhang, Jingtong Li, Yue Yang, Weiwei An, Qingyuan Zhang
BACKGROUND/AIMS: Diffuse large B-cell lymphoma (DLBCL) is an aggressive disease, and is the most common type of lymphoma in adults. Although significant progress in treatment has been made using chemotherapy combinations, there exist a large amount of relapse or refractory cases. Thus, effective clinical biomarkers for DLBCL are urgently needed. Our study aims to explore the predictive significance of using the immune response to tumor burden ratio [defined as the lymphocyte to monocyte ratio (LMR)/lactate dehydrogenase (LDH) levels] in 184 DLBCL patients and the potential mechanism underlying the use of the LMR to tumor burden ratio in predicting patient survival...
February 2, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29427369/pre-eclampsia-affects-procalcitonin-production-in-placental-tissue
#11
Chiara Agostinis, Damiano Rami, Paola Zacchi, Fleur Bossi, Tamara Stampalija, Alessandro Mangogna, Leonardo Amadio, Romana Vidergar, Liza Vecchi Brumatti, Giuseppe Ricci, Claudio Celeghini, Oriano Radillo, Ian Sargent, Roberta Bulla
PROBLEM: Procalcitonin (PCT) is the prohormone of calcitonin which is usually released from neuroendocrine cells of the thyroid gland (parafollicular) and the lungs (K cells). PCT is synthesized by almost all cell types and tissues, including monocytes and parenchymal tissue, upon LPS stimulation. To date, there is no evidence for PCT expression in the placenta both in physiological and pathological conditions. METHOD: Circulating and placental PCT levels were analysed in pre-eclamptic (PE) and control patients...
February 10, 2018: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29422900/role-of-slc7a5-in-metabolic-reprogramming-of-human-monocyte-macrophage-immune-responses
#12
Bo Ruem Yoon, Yoon-Jeong Oh, Seong Wook Kang, Eun Bong Lee, Won-Woo Lee
Amino acids (AAs) are necessary nutrients which act not only as building blocks in protein synthesis but also in crucial anabolic cellular signaling pathways. It has been demonstrated that SLC7A5 is a critical transporter that mediates uptake of several essential amino acids in highly proliferative tumors and activated T cells. However, the dynamics and relevance of SLC7A5 activity in monocytes/macrophages is still poorly understood. We provide evidence that SLC7A5-mediated leucine influx contributes to pro-inflammatory cytokine production via mTOR complex 1 (mTORC1)-induced glycolytic reprograming in activated human monocytes/macrophages...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29422500/the-tumour-microenvironment-creates-a-niche-for-the-self-renewal-of-tumour-promoting-macrophages-in-colon-adenoma
#13
Irene Soncin, Jianpeng Sheng, Qi Chen, Shihui Foo, Kaibo Duan, Josephine Lum, Michael Poidinger, Francesca Zolezzi, Klaus Karjalainen, Christiane Ruedl
Circulating CCR2+ monocytes are crucial for maintaining the adult tissue-resident F4/80hiMHCIIhi macrophage pool in the intestinal lamina propria. Here we show that a subpopulation of CCR2-independent F4/80hiMHCIIlow macrophages, which are the most abundant F4/80hi cells in neonates, gradually decline in number in adulthood; these macrophages likely represent the fetal contribution to F4/80hi cells. In colon adenomas of ApcMin/+ mice, F4/80hiMHCIIlow macrophages are not only preserved, but become the dominant subpopulation among tumour-resident macrophages during tumour progression...
February 8, 2018: Nature Communications
https://www.readbyqxmd.com/read/29417780/-subculture-cryopreservation-and-recovery-of-osteoclasts
#14
Suo-Jing Yu, Cheng-Liang Wu, Hong-Ting Jin, Xue-Qin Hu, Lu-Wei Xiao, Pei-Jian Tong
OBJECTIVE: To explore the feasibility of passage, cryopreservation, and recovery of osteoclasts in order to develop new techniques facilitating osteoclast research. METHODS: Passage of osteoclasts: adult male SD rat(SPF grade, weight of 250 g) was sacrificed and the abdominal aorta was exposed for blood draw. Monocytes isolated from peripheral circulation was treated with RANKL and M-CSF for 2 weeks. After formation of osteoclasts, they were trypsinized with pipetting, centrifuged, re-suspended with α-MEM containing RANKL and M-CSF, and cultured in 6 well-plates and 35 mm culture dishes...
May 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29416600/impaired-autophagic-flux-and-its-related-inflammation-in-patients-with-adult-onset-still-s-disease
#15
Chia-Wei Hsieh, Chun-Yu Chang, Yi-Ming Chen, Hsin-Hua Chen, Wei-Ting Hung, Ning-Rong Gung, Shiow-Jiuan Wey, Der-Yuan Chen
The pathogenic role of autophagic immune regulation in adult-onset Still's disease (AOSD) is unclear. We investigated the relative levels of autophagy in AOSD patients and healthy controls, its association with disease activity or course, and the change in autophagy after 6 months of therapy. Autophagosome levels were determined from the mean fluorescence intensity of autophagosomotropic dye incorporated into circulating immune cells. The fluorescent signal from lymphocytes, monocytes, and granulocytes from AOSD patients was greater than from controls...
January 2, 2018: Oncotarget
https://www.readbyqxmd.com/read/29415518/the-biology-of-monocytes-and-dendritic-cells-contribution-to-hiv-pathogenesis
#16
REVIEW
Vanessa Sue Wacleche, Cécile L Tremblay, Jean-Pierre Routy, Petronela Ancuta
Myeloid cells such as monocytes, dendritic cells (DC) and macrophages (MΦ) are key components of the innate immune system contributing to the maintenance of tissue homeostasis and the development/resolution of immune responses to pathogens. Monocytes and DC, circulating in the blood or infiltrating various lymphoid and non-lymphoid tissues, are derived from distinct bone marrow precursors and are typically short lived. Conversely, recent studies revealed that subsets of tissue resident MΦ are long-lived as they originate from embryonic/fetal precursors that have the ability to self-renew during the life of an individual...
February 6, 2018: Viruses
https://www.readbyqxmd.com/read/29413364/arachidonic-acid-supplementation-modulates-blood-and-skeletal-muscle-lipid-profile-with-no-effect-on-basal-inflammation-in-resistance-exercise-trained-men
#17
James F Markworth, Cameron J Mitchell, Randall F D'Souza, Kirsten M M Aasen, Brenan R Durainayagam, Sarah M Mitchell, Alex H C Chan, Andrew J Sinclair, Manohar Garg, David Cameron-Smith
Arachidonic acid (ARA), an omega-6 polyunsaturated fatty acid (PUFA), is the metabolic precursor to the eicosanoid family of lipid mediators. Eicosanoids have potent pro-inflammatory actions, but also act as important autocrine/paracrine signaling molecules in skeletal muscle growth and development. Whether dietary ARA is incorporated into skeletal muscle phospholipids and the resulting impact on intramuscular inflammatory and adaptive processes in-vivo is not known. In the current study, resistance trained men (≥1 year) received dietary supplementation with 1...
January 2018: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/29395574/up-regulated-expression-of-cd86-on-circulating-intermediate-monocytes-correlated-with-disease-severity-in-psoriasis
#18
Chuyen Thi Hong Nguyen, Naotomo Kambe, Fumikazu Yamazaki, Ikuko Ueda-Hayakawa, Izumi Kishimoto, Hiroyuki Okamoto
BACKGROUND: The number of intermediate monocytes (CD14++CD16+) increases in many inflammatory conditions. However, it is not yet known which functional markers expressed by these populations are linked to the pathogenesis of psoriasis. OBJECTIVES: We evaluated the expression of functional markers on circulating intermediate monocytes. Our goal was to correlate specific populations and their markers with the clinical severity of psoriasis. METHODS: A cohort of 43 psoriatic patients was subjected to analysis...
January 27, 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29393104/downregulated-expression-of-trpv2-in-peripheral-blood-cells-following-acute-myocardial-infarction-is-inversely-correlated-with-serum-levels-of-crp-and-troponin-i
#19
Zach Rozenbaum, Lena Cohen, Einat Bigelman, Yacov Shacham, Gad Keren, Michal Entin-Meer
OBJECTIVES: We have recently shown that the transient receptor potential vanilloid 2 (TRPV2) channel is exclusively upregulated in rat/murine peri-infarct monocytes/macrophages following an acute myocardial infarction (AMI), and that this overexpression might be detrimental for cardiac recovery. We aimed to characterize the expression levels of TRPV2 in peripheral blood mononuclear cells (PBMCs) of AMI patients relative to individuals with normal coronaries, and to analyze potential associations with inflammatory and cardiac ischemic markers...
January 26, 2018: Cardiology
https://www.readbyqxmd.com/read/29390091/identification-and-characterization-at-the-single-cell-level-of-cytokine-producing-circulating-cells-in-children-with-dengue
#20
Federico Perdomo-Celis, Felipe Romero, Doris M Salgado, Rocío Vega, Jairo Rodríguez, Juana Angel, Manuel A Franco, Harry B Greenberg, Carlos F Narváez
In this study we identified, at the single-cell level, naturally induced cytokine-producing circulating cells (CPCC) in children with dengue virus (DENV) infection ranging clinically from mild to severe disease. Tumor necrosis factor (TNF)-α- and Interleukin (IL)-6-CPCC were detected in children with primary or secondary acute DENV infection and the pattern of these cytokines was similar to that seen in the supernatant of cultured PBMC and partially comparable to that found in the plasma. Monocytes, B cells (BC), and myeloid dendritic cells (mDC) were the primary CPCC detected, and the frequency of mDC was significantly higher in severe disease...
January 30, 2018: Journal of Infectious Diseases
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