Mengjuan Zhang, Yude Guan, Meijuan Han, Fandi Kong, Aoyu Xu, Xiaohan Jin, Xiao Hu, Fang Dong, Nianchao Zhang, Xiuping Peng, Dantong Liu, Yongyan Chen, Ruxin Zhao, Xiulei Zhu, Yanan Zhang, Congcong Lu, Wen Hou, Lei Liu, Dan Li, Zhihui Zhang, Xiaomin Zhang, Song Zhang
T-helper 17 (Th17) cells play a dual role in immunological responses, serving as essential components in tissue homeostasis and host defense against microbial pathogens while also contributing to pro-inflammatory conditions and autoimmunity. While Transforming Growth Factor-beta 1 (TGFβ1) is pivotal for the differentiation of non-pathogenic Th17 cells, the role of TGFβ3 and Activin in steering Th17 cells toward a pathogenic phenotype has been acknowledged. However, the molecular mechanisms governing this dichotomy remain elusive...
January 9, 2024: Journal of Leukocyte Biology