Siji Zhao, Ruya Yin, Mengwei Zhang, Ziqi Zhai, Zhen Shen, Yan Mou, Dan Xu, Ligang Zhou, Daowan Lai
The endophytic fungus Berkleasmium sp. Dzf12 that was isolated from Dioscorea zingiberensis, is a proficient producer of palmarumycins, which are intriguing polyketides of the spirobisnaphthalene class. These compounds displayed a wide range of bioactivities, including antibacterial, antifungal, and cytotoxic activities. However, conventional genetic manipulation of Berkleasmium sp. Dzf12 is difficult and inefficient, partially due to the slow-growing, non-sporulating, and highly pigmented behavior of this fungus...
April 23, 2024: World Journal of Microbiology & Biotechnology