keyword
MENU ▼
Read by QxMD icon Read
search

antibacterial

keyword
https://www.readbyqxmd.com/read/29679907/in-vitro-screening-homology-modeling-and-molecular-docking-studies-of-some-pyrazole-and-imidazole-derivatives
#1
Farid Abrigach, Yahya Rokni, Abdelilah Takfaoui, Mohamed Khoutoul, Henri Doucet, Abdeslam Asehraou, Rachid Touzani
A series of synthesized compounds based on pyrazole and imidazole skeletons prepared by palladium catalysts via a one-pot reaction was screened to determine their inhibitory potency against the pathogen fungus Fusarium oxysporum f.sp. albedinis (F.o.a) and four bacteria strains namely Micrococcus luteus, Bacillus subtilis, Staphylococcus aureus and Escherichia coli. The obtained result showed that these compounds exhibit an efficiency antifungal action. Whereas, they showed a very weak antibacterial activity...
April 18, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29679863/discovery-of-new-gyrase-%C3%AE-inhibitors-via-structure-based-modeling
#2
Afaf H Al-Nadaf, Sajeda A Salah, Mutasem O Taha
Gyrase B is an essential enzyme in the prokaryotes which became an attractive target for antibacterial agents. In our study, we implemented a wide range of docking configurations to dock 120 inhibitors into the in the ATP- binding pocket of Gyrase B enzyme (PDB code: 4GEE). LigandFit docking engines and six scoring functions were utilized in the study. Furthermore, the ligands were docked in their ionized and unionized forms into the hydrous and anhydrous binding pocket. We used docking-based Comparative Intermolecular Contacts Analysis (db-CICA) which is a novel methodology to validate and identify the optimal docking configurations...
March 19, 2018: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/29679784/a-swinging-seesaw-as-a-novel-model-mechanism-for-time-dependent-hormesis-under-dose-dependent-stimulatory-and-inhibitory-effects-a-case-study-on-the-toxicity-of-antibacterial-chemicals-to-aliivibrio-fischeri
#3
Haoyu Sun, Edward J Calabrese, Min Zheng, Dali Wang, Yongzheng Pan, Zhifen Lin, Ying Liu
Hormesis occurs frequently in broadly ranging biological areas (e.g. plant biology, microbiology, biogerontology), toxicology, pharmacology and medicine. While numerous mechanisms (e.g. receptor and pathway mediated pathway responses) account for stimulatory and inhibitory features of hormetic dose responses, the vast majority emphasizes the inclusion of many doses but only one timepoint or use of a single optimized dose that is assessed over a broad range of timepoints. In this paper, a toxicity study was designed using a large number of properly spaced doses with responses determined over a large number of timepoints, which could help us reveal the underlying mechanism of hormesis...
April 10, 2018: Chemosphere
https://www.readbyqxmd.com/read/29679711/establishment-of-a-drug-induced-rhabdomyolysis-mouse-model-by-co-administration-of-ciprofloxacin-and-atorvastatin
#4
Akiko Matsubara, Shingo Oda, Sho Akai, Koichi Tsuneyama, Tsuyoshi Yokoi
Rhabdomyolysis is one of the serious side effects of ciprofloxacin (CPFX), a widely used antibacterial drug; and occasionally, acute kidney injury (AKI) occurs. Often, rhabdomyolysis has occurred in patients taking CPFX co-administered with statins. The purpose of this study is to establish a mouse model of drug-induced rhabdomyolysis by co-administration of CPFX and atorvastatin (ATV) and to clarify the mechanisms of its pathogenesis. C57BL/6J mice treated with L-buthionine-(S,R)-sulfoximine (BSO), a glutathione synthesis inhibitor, were orally administered with CPFX and ATV for 4 days...
April 18, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/29679358/peptides-from-chia-present-antibacterial-activity-and-inhibit-cholesterol-synthesis
#5
Michele Silveira Coelho, Rosana Aparecida Manólio Soares-Freitas, José Alfredo Gomes Arêas, Eliezer Avila Gandra, Myriam de Las Mercedes Salas-Mellado
In previous studies, it has not been reported that protein isolated from chia interferes favorably with antibacterial activity, and reduces cholesterol synthesis. The objective of this study was to determine whether commonly used commercial microbial proteases can be utilized to generate chia protein-based antibacterial and hypocholesterolemic hydrolysates/peptides, considering the effects of protein extraction method. Alcalase, Flavourzyme and sequential Alcalase-Flavourzyme were used to produce hydrolysates from chia protein (CF), protein-rich fraction (PRF) and chia protein concentrates (CPC1 and CPC2)...
April 20, 2018: Plant Foods for Human Nutrition
https://www.readbyqxmd.com/read/29679285/exploration-of-phyllanthus-acidus-mediated-silver-nanoparticles-and-its-activity-against-infectious-bacterial-pathogen
#6
Cherukuri Sowmya, Vuppalapati Lavakumar, Narayanan Venkateshan, Velayutham Ravichandiran, D V R Saigopal
In our present investigation, synthesis of nontoxic, eco friendly and cost effective silver nanoparticles, Phyllanthus acidus (P. acidus) was used as starting material. The influence of phyto-constituents present in aqueous extracts of Phyllanthus acidus was found to be effective in reduction of silver nitrate to free silver nanoparticles (PA-AgNPs). HPTLC finger print analysis reveals the presence of flavonoid, quercetin in aqueous extracts of Phyllanthus acidus. Surface plasmon racemonance exhibited λ max at 462 nm through UV-Vis spectroscopy...
April 20, 2018: Chemistry Central Journal
https://www.readbyqxmd.com/read/29678916/identification-of-laoabcr-as-a-novel-system-for-the-oxidation-of-long-chain-alcohols-derived-from-sds-and-alkane-degradation-in-pseudomonas-aeruginosa
#7
Gianna Panasia, Bodo Philipp
The opportunistic pathogen Pseudomonas aeruginosa strain PAO1 is able to use a variety of organic pollutants as growth substrates including the anionic detergent sodium dodecyl sulfate (SDS) and long-chain alkanes. While the enzymes initiating SDS and alkane degradation are well known, the following enzymatic steps for degradation of the derived primary long-chain alcohols have not been identified yet. By evaluating genes specifically induced during growth with SDS, a gene cluster encoding a putative alcohol dehydrogenase (PA0364/LaoA), a probable inner membrane protein (PA0365/LaoB) and a presumable aldehyde dehydrogenase (PA0366/LaoC) were identified and designated as Lao (<u>l</u>ong-chain-<u>a</u>lcohol/<u>a</u>ldehyde-<u>o</u>xidation) system...
April 20, 2018: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29678738/autochthonous-lactic-acid-bacteria-isolated-from-pig-faeces-in-thailand-show-probiotic-properties-and-antibacterial-activity-against-enteric-pathogenic-bacteria
#8
Wandee Sirichokchatchawan, Puwiya Pupa, Prasert Praechansri, Nutthee Am-In, Somboon Tanasupawat, Piengchan Sonthayanon, Nuvee Prapasarakul
Lactic acid bacteria (LAB) play an important role in pig health and performance that arises from their beneficial impacts on the balance of gastrointestinal microbes, ability to fight enteric pathogens, and capacity to support the immune system. The aim of this study was to evaluate the functional and safety aspects of five previously isolated autochthonous LAB strains, (Lactobacillus plantarum 22F, 25F and 31F, Pediococcus acidilactici 72N and Pediococcus pentosaceus 77F) from pig faeces as potential probiotics for a pig feed supplement...
April 17, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29678695/the-imd-pathway-regulates-lysozyme-like-proteins-llps-in-the-silkmoth-antheraea-mylitta
#9
Valluri V Satyavathi, Amr A Mohamed, Swetha Kumari, Dadala M Mamatha, Bernard Duvic
Lysozyme-like proteins (LLPs) are members of the glycoside hydrolase family 22 (CAZY GH22). Unlike conventional c-type lysozymes (EC 3.2.1.17), LLPs lack specific catalytic amino acid residues essential for muramidase activity. Previous reports indicated upregulation of LLPs upon bacterial infection in the wild silkworm, Antheraea mylitta as well as in the domesticated silkworm, Bombyx mori. In the present work, we studied the signaling pathways mediating the production of LLPs using RNA interference-mediated knockdown of Spätzle, Relish and STAT, the key regulators of Toll, IMD (Immune deficiency) and JAK/STAT pathways, respectively...
April 17, 2018: Journal of Invertebrate Pathology
https://www.readbyqxmd.com/read/29678565/simplification-of-first-line-antibacterial-regimen-for-complicated-appendicitis-in-children-was-associated-with-better-adherence-to-guidelines-and-reduced-use-of-antibiotics
#10
Marion Taleb, Nicolas Nardi, Alexis Arnaud, Nathalie Costet, Pierre-Yves Donnio, Charlotte Engrand, Edouard Habonimana, Eric Wodey, Pierre Tattevin
Acute appendicitis in children requires early surgery, and a short course of antibiotics active on Enterobacteriaceae and anaerobes. Although aminoglycoside-containing 3-drug regimen have been used successfully for decades, simpler regimens with similar efficacy are increasingly used. We aimed to evaluate the impact of a switch from the combination of cefotaxime, metronidazole, and gentamicin (regimen 1), to piperacillin-tazobactam (regimen 2), as first-line regimen for complicated acute appendicitis in children...
April 17, 2018: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29678543/hollow-mesoporous-hydroxyapatite-nanostructures-smart-nanocarriers-with-high-drug-loading-and-controlled-releasing-features
#11
M Usman Munir, Ayesha Ihsan, Yasra Sarwar, Sadia Zafar Bajwa, Khizra Bano, Bushra Tehseen, Neelam Zeb, Irshad Hussain, M Tayyab Ansari, Madiha Saeed, Juan Li, M Zubair Iqbal, Aiguo Wu, Waheed S Khan
We report the development of effective drug loaded nanocarriers to combat multidrug resistant infection especially in case of osteomyelitis. The hollow mesoporous hydroxyapatite nanoparticles (hmHANPs) and solid/non-hollow hydroxyapatite nanoparticles (sHANPs) were synthesized by core-shell and co-precipitation techniques respectively. High encapsulation of the drug (ciprofloxacin) was observed in hmHANPs as compared to sHANPs, which may be due to the hollow porous structure of hmHANPs. These nanoparticles were characterized by scanning electron microscope (FESEM), N2 adsorption/desorption, Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) and Thermogravimetric analysis (TGA)...
April 17, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29678533/a-chitinase-from-pacific-white-shrimp-litopenaeus-vannamei-involved-in-immune-regulation
#12
Shengwen Niu, Linwei Yang, Hongliang Zuo, Jiefu Zheng, Shaoping Weng, Jianguo He, Xiaopeng Xu
Chitinases are a group of hydrolytic enzymes that hydrolyze chitin and widely exist in organisms. Studies in mammals have demonstrated that chitinases play important roles in regulation of humoral and cellular immune responses. In arthropods, although it is well known that chitinases are involved in growth, molting and development, the current knowledge on the role of chitinases in immunity, especially in immune regulation, remains largely unknown. In this study, a chitinase (LvChi5) from Litopenaeus vannamei was representatively selected for studying its immune function...
April 17, 2018: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/29678329/antibacterial-photocatalytic-activity-of-different-crystalline-tio-2-phases-in-oral-multispecies-biofilm
#13
Heloisa N Pantaroto, Antonio P Ricomini-Filho, Martinna M Bertolini, José H D Silva, Nilton F Azevedo Neto, Cortino Sukotjo, Elidiane C Rangel, Valentim A R Barão
OBJECTIVE: Titanium dioxide (TiO2 ) incorporation in biomaterials is a promising technology due to its photocatalytic and antibacterial activities. However, the antibacterial potential of different TiO2 crystalline structures on a multispecies oral biofilm remains unknown. We hypothesized that the different crystalline TiO2 phases present different photocatalytic and antibacterial activities. METHODS: Three crystalline TiO2 films were deposited by magnetron sputtering on commercially pure titanium (cpTi), in order to obtain four groups: (1) machined cpTi (control); (2) A-TiO2 (anatase); (3) M-TiO2 (mixture of anatase and rutile); (4) R-TiO2 (rutile)...
April 17, 2018: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/29678327/antibacterial-quaternary-ammonium-compounds-in-dental-materials-a-systematic-review
#14
REVIEW
Pooyan Makvandi, Rezvan Jamaledin, Mostafa Jabbari, Nasser Nikfarjam, Assunta Borzacchiello
OBJECTIVE: Quaternary ammonium compounds (QACs) represent one of the most effective classes of disinfectant agents in dental materials and resin nanocomposites. This reviews aims to give a wide overview on the research in the field of antibacterial QACs in dental materials and nanocomposites. METHOD: An introduction to dental materials components as well as the microorganisms and methods of evaluation for the antimicrobial assays are presented. Then, the properties and synthesis route of QACs, as monomer and filler, are shown...
April 17, 2018: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/29678262/tolfenamic-acid
#15
Sofia Ahmed, Muhammad Ali Sheraz, Iqbal Ahmad
Tolfenamic acid (TA) is a nonsteroidal antiinflammatory drug and belongs to the group of fenamates. It is used as a potent pain reliever in the treatment of acute migraine attacks, and disorders like dysmenorrhea, rheumatoid, and osteoarthritis. TA has shown excellent in vitro antibacterial activity against certain ATCC strains of bacteria when complexed with bismuth(III). It has also been reported to block pathological processes associated with Alzheimer's disease. In the recent past, TA has also been used as a novel anticancer agent for the treatment of various cancers...
2018: Profiles of Drug Substances, Excipients, and related Methodology
https://www.readbyqxmd.com/read/29677907/re-renal-sodium-gradient-orchestrates-a-dynamic-antibacterial-defense-zone
#16
Anthony Atala
No abstract text is available yet for this article.
May 2018: Journal of Urology
https://www.readbyqxmd.com/read/29677795/facile-synthesis-of-efficient-antibacterial-agent-as-cofe%C3%A2-o%C3%A2-ag-composite-material-against-both-gram-negative-escherichia-coli-and-gram-positive-bacillus-subtilis-bacteria
#17
Sukhbayar Gankhuyag, Kyoung Lee, Dong Sik Bae
We have suggested that a facile synthesis of CoFe2O4/Ag composite material as an antibacterial agent for substitution of a chlorination agent for microbial infected wastewater treatment. The CoFe2O4/Ag was synthesized by an impregnation method in assistance with trisodium citrate as a reducing agent. The as-prepared uncalcined CoFe2O4 (CFG), calcined CoFe2O4 (CFG600), and calcined CoFe2O4/Ag (CFG600/Ag) composites were characterized by X-ray diffraction (XRD), Field Emission Scanning Electron Microscope (FE-SEM) and Energy Dispersive X-ray (EDX) techniques...
September 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29677644/antimicrobial-activity-and-cytotoxicity-of-xanthoquinodin-analogs-from-the-fungus-cytospora-eugeniae-bcc42696
#18
Karoon Sadorn, Siriporn Saepua, Nattawut Boonyuen, Tanapong Boonruangprapa, Pranee Rachtawee, Pattama Pittayakhajonwut
Eleven previously undescribed compounds, including cytosporanthraxanthone, xanthoquinodins A7-A10, ketoxanthoquinodin A6, xanthoquinodins B6-B8, and spiroxanthoquinodins A and B, and one synthetically known compound, 2-methoxy pinselin, as well as ten known compounds, including xanthoquinodins A4-A6, B4, and B5, chrysophanol, physcion, (4S)-5-hydroxy-4-methoxy-α-tetralone, (4S)-4,8-dihydroxy-α-tetralone (or isosclerone), and gonytolide C were isolated from the fungus Cytospora eugeniae BCC42696. Their chemical structures were determined based on the analysis of NMR spectroscopic and mass spectrometric data...
April 17, 2018: Phytochemistry
https://www.readbyqxmd.com/read/29677599/bactericidal-activity-and-mechanisms-of-biobr-agbr-under-both-dark-and-visible-light-irradiation-conditions
#19
Ting Feng, Jialiang Liang, Zhiyao Ma, Mian Li, Meiping Tong
BiOBr-AgBr hybrid photocatalysts were synthesized via a facile precipitation and in-situ ion exchange method at room temperature. The as-synthesized photocatalysts were well characterized with different techniques. The disinfection activities of BiOBr-AgBr towards model bacterial strain Gram-negative Escherichia coli (E. coli) were tested under both dark and visible light irradiation conditions. 1 × 107 CFU/mL of E. coli cells could be completely inactivated by BiOBr-AgBr with the optimal silver amount (BiOBr-0...
April 8, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29676579/antibacterial-indole-alkaloids-with-complex-heterocycles-from-voacanga-africana
#20
Cai-Feng Ding, Hong-Xia Ma, Jing Yang, Xu-Jie Qin, Guy S S Njateng, Hao-Fei Yu, Xin Wei, Ya-Ping Liu, Wan-Yi Huang, Zi-Feng Yang, Xin-Hua Wang, Xiao-Dong Luo
Voacafricines A and B, two unique monoterpenoid indole alkaloids each bearing five fused heterocycles, were obtained from the fruits of Voacanga africana. Their structures were elucidated by extensive spectroscopic methods and computational studies. A plausible biogenetic pathway was proposed from a common precursor, 19- epi-voacristine. Both compounds exhibited potent activity against Staphylococcus aureus and Salmonella typhi, and their activities were superior to those of the well-known antibacterial drugs berberine and fibrauretine...
April 20, 2018: Organic Letters
keyword
keyword
32071
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"