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https://www.readbyqxmd.com/read/28651162/antibacterial-activity-corrosion-resistance-and-wear-behavior-of-spark-plasma-sintered-ta-5cu-alloy-for-biomedical-applications
#1
Jing Cui, Liang Zhao, Weiwei Zhu, Bi Wang, Cancan Zhao, Liming Fang, Fuzeng Ren
Tantalum has been widely used in orthopedic and dental implants. However, the major barrier to the extended use of such medical devices is the possibility of bacterial adhesion to the implant surface which will cause implant-associated infections. To solve this problem, bulk Ta-5Cu alloy has been fabricated by a combination of mechanical alloying and spark plasma sintering. The effect of the addition of Cu on the hardness, antibacterial activity, cytocompatibility, corrosion resistance and wear performance was systematically investigated...
June 21, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28650788/comparison-of-the-antimicrobial-efficacy-of-the-endovac-system-and-conventional-needle-irrigation-in-primary-molar-root-canals
#2
Burak Buldur, Arife Kapdan
PURPOSE: The purpose of this study was to compare the antimicrobial efficacy of the EndoVac system and conventional needle irrigation to eliminate E faecalis in primary molar root canals. STUDY DESIGN: 60 extracted human primary second molar roots were instrumented up to an apical size .04/35 and randomly divided into two groups; Group 1: conventional needle (n=30) and Group 2: EndoVac (n=30), and four subgroups (two experimental subgroups; (a) 2.5% sodium hypochlorite (NaOCl) + ethylenediaminetetraacetic acid (EDTA) (n=20), (b) ozonated water (OW) + EDTA (n=20), and control groups (c) 5...
2017: Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/28650661/triaryl-benzimidazoles-as-a-new-class-of-antibacterial-agents-against-resistant-pathogenic-microorganisms
#3
Pietro Picconi, Charlotte Hind, Shirin Jamshidi, Kazi Nahar, Melanie Clifford, Matthew E Wand, J Mark Sutton, K Miraz Rahman
A new class of non-toxic triaryl benzimidazole compounds, derived from existing classes of DNA minor groove binders, were designed, synthesized and evaluated for their antibacterial activity against multi-drug resistant (MDR) Gram-positive and Gram-negative species. Molecular modelling experiments suggest that the newly synthesized class cannot be accommodated within the minor groove of DNA, due to a change in the shape of the molecules. Compounds 8, 13 and 14 were found to be the most active of the series, with MICs in the range of 0...
June 26, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28650559/the-antibacterial-activity-and-modes-of-li-f-type-antimicrobial-peptides-against-bacillus-cereus-in-vitro
#4
Jinzhi Han, Shengming Zhao, Zhi Ma, Ling Gao, Hongxia Liu, Umair Muhammad, Zhaoxin Lu, Fengxia Lv, Xiaomei Bie
AIMS: LI-Fs are a family of highly potent cyclic lipodepsipeptide antibiotics with a broad antimicrobial spectrum (Gram-positive bacteria and fungi). In this study, LI-F type antimicrobial peptides (AMP-jsa9) composing of LI-F03a, LI-F03b, LI-F04a, LI-F04b, and LI-F05b were isolated from Paenibacillus polymyxa JSA-9. To better understand the antimicrobial mechanism of AMP-jsa9, the potency and action(s) of AMP-jsa9 against B. cereus were examined. METHODS AND RESULTS: Flow cytometry, confocal laser microscopy, scanning electron microscopy (SEM), transmission electron microscopy (TEM), and atomic force microscopy (AFM) observation, as well as determination of peptidoglycan and cell wall associated protein, and other methods were used...
June 26, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/28650486/advanced-carbon-dots-via-plasma-induced-surface-functionalization-for-fluorescent-and-bio-medical-applications
#5
So Young Park, Che Yoon Lee, Ha-Rim An, Hyeran Kim, Young-Chul Lee, Edmond Changkyun Park, Hang-Suk Chun, Hee Young Yang, Sae-Hae Choi, Hee Sik Kim, Kyoung Suk Kang, Hyun Gyu Park, Jong-Pil Kim, Yunju Choi, Jouhahn Lee, Hyun Uk Lee
Multifunctional carbon-based nanodots (C-dots) are synthesized using atmospheric plasma treatments involving reactive gases (oxygen and nitrogen). Surface design was achieved through one-step plasma treatment of C-dots (AC-paints) from polyethylene glycol used as a precursor. These AC-paints show high fluorescence, low cytotoxicity and excellent cellular imaging capability. They exhibit bright fluorescence with a quantum yield twice of traditional C-dots. The cytotoxicity of AC-paints was tested on BEAS2B, THLE2, A549 and hep3B cell lines...
June 26, 2017: Nanoscale
https://www.readbyqxmd.com/read/28650325/evaluation-of-three-plant-extracts-against-biofilm-formation-and-expression-of-quorum-sensing-regulated-virulence-factors-in-pseudomonas-aeruginosa
#6
Vajihe Karbasizade, Parichehr Dehghan, Maryam Mohammadi Sichani, Kahin Shahanipoor, Reyhaneh Jafari, Rozita Yousefian
Following the increasing antibiotic resistance of pathogenic bacteria, the use of medicinal herbs as antibacterial agents has attracted growing attention. Pseudomonas aeruginosa is a human opportunistic pathogen that uses quorum sensing for regulating virulence gene expression (pyocyanin, protease, and elastase production and biofilm formation). This study examined the anti-quorum sensing activity of Quercus infectoria, Zataria multiflora and Trachyspermum copticum extracts on standard P. aeruginosa strain...
March 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28650175/bioactive-peptide-natural-products-as-lead-structures-for-medicinal-use
#7
Tam Dang, Roderich D Süssmuth
The need for new drugs for the treatment of various diseases is enormous. From the previous century until the present, numerous peptide and peptide-derived natural products have been isolated from bacteria and fungi. Hence, microorganisms play a pivotal role as sources for novel drugs with an emphasis on anti-infective agents. Various disciplines from biology, chemistry, and medicine are involved in early stages of the search for peptide natural products including taxonomy, microbiology, bioanalytics, bioinformatics, and medicinal chemistry...
June 26, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28650068/rational-engineering-of-p-hydroxybenzoate-hydroxylase-to-enable-efficient-gallic-acid-synthesis-via-a-novel-artificial-biosynthetic-pathway
#8
Zhenya Chen, Xiaolin Shen, Jian Wang, Jia Wang, Qipeng Yuan, Yajun Yan
Gallic acid (GA) is a naturally occurring phytochemical that has strong antioxidant and antibacterial activities. It is also used as a potential platform chemical for the synthesis of diverse high-value compounds. Hydrolytic degradation of tannins by acids, bases or microorganisms serves as a major way for GA production, which however, might cause environmental pollution and low yield and efficiency. Here, we report a novel approach for efficient microbial production of GA. First, structure-based rational engineering of PobA, a p-hydroxybenzoate hydroxylase from Pseudomonas aeruginosa, generated a new mutant, Y385F/T294A PobA, which displayed much higher activity towards 3,4-dihydroxybenzoic acid (3,4-DHBA) than the wild type and any other reported mutants...
June 26, 2017: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/28649412/surface-topology-affects-wetting-behavior-of-bacillus-subtilis-biofilms
#9
Moritz Werb, Carolina Falcón García, Nina C Bach, Stefan Grumbein, Stephan A Sieber, Madeleine Opitz, Oliver Lieleg
The colonization of surfaces by bacterial biofilms constitutes a huge problem in healthcare and industry. When attempting biofilm inactivation or removal, it is crucial to sufficiently wet the biofilm surface with antibacterial agents; however, certain biofilms efficiently resist wetting, and the origin of this behavior remains to date unclear. Here, we demonstrate that, depending on the growth medium used, the model bacterium Bacillus subtilis can form biofilm colonies with distinct surface properties: we find either hydrophilic or two variants of hydrophobic behavior...
2017: NPJ Biofilms and Microbiomes
https://www.readbyqxmd.com/read/28649410/komodo-dragon-inspired-synthetic-peptide-drgn-1-promotes-wound-healing-of-a-mixed-biofilm-infected-wound
#10
Ezra M C Chung, Scott N Dean, Crystal N Propst, Barney M Bishop, Monique L van Hoek
Cationic antimicrobial peptides are multifunctional molecules that have a high potential as therapeutic agents. We have identified a histone H1-derived peptide from the Komodo dragon (Varanus komodoensis), called VK25. Using this peptide as inspiration, we designed a synthetic peptide called DRGN-1. We evaluated the antimicrobial and anti-biofilm activity of both peptides against Pseudomonas aeruginosa and Staphylococcus aureus. DRGN-1, more than VK25, exhibited potent antimicrobial and anti-biofilm activity, and permeabilized bacterial membranes...
2017: NPJ Biofilms and Microbiomes
https://www.readbyqxmd.com/read/28649072/investigation-of-composition-extracts-biological-activities-and-optimization-of-solanum-nigrum-l-extraction-growing-in-iran
#11
Akbar Esmaeili, Abdul Rahman Tahazadeh, Mohammad Ali Ebrahimzadeh
Raw materials including medicinal plants are gaining popularity for the production of reliable and safe medicines suitable for human. Response Surface Methodology (RSM) is a collection of mathematical and statistical techniques used for solving the optimization problems. Using the RSM method, compounds, extracts, antioxidant and antibacterial agents of methanol, hexane, chloroform and water extracts of black nightshade (Solanum nigrum) found in Iran, had been studied for this research. GC and GC/MS had been used to determine the composition of the extracts from the aerial parts of S...
March 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28649069/altered-antibacterial-activity-of-curcumin-in-the-presence-of-serum-albumin-plasma-and-whole-blood
#12
Sin Yeang Teow, Syed A Ali
Antibacterial effect is one of the major therapeutic activities of plant-derived Curcumin. This work evaluated the effect of serum albumin, human plasma, and whole blood on the in vitro activity of Curcumin against eight clinical bacterial isolates by standard broth microdilution and plate-counting methods. Toxicological effects of Curcumin towards human red blood cells (RBCs) and peripheral blood mononuclear cells (PBMCs) were also investigated. Curcumin exhibited weak activity against gram-negative bacteria, except Escherichia coli and Shigella flexneri were susceptible and was most active against gram-positive bacteria: Staphylococcus aureus, Streptococcus pyogenes and Enterococcus faecalis...
March 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28649062/antibacterial-activity-of-penicillins-alone-and-in-combination-with-different-agents-against-staphylococcus-aureus
#13
Sumbal Nosheen, Hasan Ejaz, Aizza Zafar, Hafeez Ikram
Difficulties in the treatment of the resistant strains of Staphylococcus aureus, which is a frequent cause of nosocomial infections in paediatric patients, has prompted this research to empower the usage of various combinations of penicillin. During the study period 17,452 clinical samples were processed for culture. The positive cultures yielded 564 strains of S. aureus. Out of these, 362 (64.2%) isolates were found to be methicillin sensitive S. aureus (MSSA) and 202 (35.8%) methicillin resistant S. aureus (MRSA)...
March 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28649006/optimization-of-hydrogel-containing-toluidine-blue-o-for-photodynamic-therapy-by-response-surface-methodology
#14
Hui Liang, Jialin Xu, Yunfeng Liu, Jianxing Zhang, Wei Peng, Jinhua Yan, Zelin Li, Qingyong Li
Photodynamic therapy with toluidine blue O (TBO) hydrogel exhibits antibacterial activity against Staphylococcus aureus and Escherichia coli in this paper. The response surface methodology is employed to optimize formulations for antibacterial activity. The optimal formulations are carbomer concentration of 3% (w/v), TBO concentration of 0.1mg/mL and the quality ratio of NaOH and carbomer of 0.4 (w/w). Under the optimized formulations, the log-transformed of CFUmL(-1) on the Staphylococcus aureus and Escherichia coli are 0...
June 16, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28648972/diallyl-trisulfide-a-garlic-polysulfide-protects-against-as-induced-renal-oxidative-nephrotoxicity-apoptosis-and-inflammation-in-rats-by-activating-the-nrf2-are-signaling-pathway
#15
S Miltonprabu, N C Sumedha, P Senthilraja
BACKGROUND: Arsenic (As) contamination is an extremely dangerous global environmental problem as it can enter into the food chain and become bio-accumulated, endangering human health. Chronic As intoxication leads to undesirable toxic effects in various organ systems of the body, especially the kidney. Diallyl trisulfide (DATS) is an organosulfur compound which has been widely known for its uses as antibacterial, antitumorogenic, antioxidant agent and has been also reported to have anti-apoptotic and anti-inflammatory properties...
June 22, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28648884/epigallocatechin-3-gallate-inhibit-replication-of-white-spot-syndrome-virus-in-scylla-paramamosain
#16
Zhi Wang, Baozhen Sun, Fei Zhu
Epigallocatechin-3-gallate (EGCG) has exhibited potential antibacterial and anticancer activities. In this study, we tested whether EGCG can protect the mud crab Scylla paramamosain against white spot syndrome virus (WSSV). Treatment with 1.5 mg/kg EGCG killed crab hemocytes but treatment with 1 mg/kg EGCG did not. Results of the virus challenge experiment confirmed that EGCG could enhance the survival rate of WSSV-challenged crabs, and treatment with 1 mg/kg EGCG significantly increased their resistance to WSSV compared with the control...
June 22, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28648853/next-generation-sequencing-of-oral-microbiota-in-type-2-diabetes-mellitus-prior-to-and-after-neem-stick-usage-and-correlation-with-serum-monocyte-chemoattractant-1
#17
Rubini Anbalagan, Padma Srikanth, Monika Mani, Ramya Barani, Krishna G Seshadri, R Janarthanan
INTRODUCTION: Oral microbiome impacts health and disease. T2DM and periodontitis are associated. Neem (Azadiracta indica) has antibacterial activity against oral microbiota. OBJECTIVES: To characterize oral microbiota (OMB) in saliva samples of T2DM patients by Next generation sequencing. To analyze MCP-1 levels among the T2DM patients before and after a month of neem stick usage as a toothbrush. MATERIALS AND METHODS: Blood and saliva samples were collected from adult T2DM patients before and after the neem stick usage...
June 13, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28648647/in-vitro-antibacterial-activity-of-fosfomycin-combined-with-other-antimicrobials-against-kpc-producing-klebsiella-pneumoniae
#18
Wei Yu, Ping Shen, Zhang Bao, Kai Zhou, Beiwen Zheng, Jinru Ji, Lihua Guo, Chen Huang, Yonghong Xiao
The increasing prevalence of KPC-producing Klebsiella pneumoniae (KPC-Kp) strains poses a serious threat to patients. Therapeutic options are limited to colistin, fosfomycin, tigecycline and selected aminoglycosides. Although the combination of fosfomycin with other antimicrobials is recommended, data regarding possible synergistic activity in vitro and in vivo appear inconsistent. Here we report that five drug combinations (fosfomycin combined with imipenem, ertapenem, tigecycline, colistin or amikacin) had a significant additive effect against 136 KPC-Kp strains in an in vitro chequerboard assay...
June 22, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28648632/purification-characterization-cloning-and-structural-analysis-of-crocodylus-siamensis-ovotransferrin-for-insight-into-functions-of-iron-binding-and-autocleavage
#19
Sukanya Chaipayang, Chomphunuch Songsiriritthigul, Chun-Jung Chen, Philip M Palacios, Brad S Pierce, Nisachon Jangpromma, Sompong Klaynongsruang
Ovotransferrin, the major protein constituent of egg white, is of great interest due to its pivotal role in biological iron transport and storage processes and its spontaneous autocleavage into peptidic fragments with alternative biological properties, such antibacterial and antioxidant activity. However, despite being well-investigated in avian, a detailed elucidation of the structure-function relationship of ovotransferrins in the closely related order of Crocodilia has not been reported to date. In this study, electron paramagnetic resonance (EPR) confirmed the presence of two spectroscopically distinct ferric iron binding sites in Crocodylus siamensis OTf (cOTf), but implied a five-fold lower quantity of bound iron than in hen OTf (hOTf)...
June 22, 2017: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/28648631/flavonoids-from-artificially-induced-dragon-s-blood-of-dracaena-cambodiana
#20
Hui Wang, He-Mei Jiang, Fei-Xiang Li, Hui-Qin Chen, Wen-Chao Liu, Shou-Zhong Ren, Wen-Li Mei, Hao-Fu Dai
Dragon's blood is a rare traditional medicine used in many countries. Because of its various therapeutic uses, its requirement is increasing dramatically, while formation of dragon's blood need at least several years, so many researchers tried to induce the formation of dragon's blood artificially, but the chemical constituents of artificially induced dragon's blood were rarely studied. In our research, twenty constituents, including three new ones, were isolated from artificially induced dragon's blood of Dracaena cambodiana, five of which are the same with those from natural dragon's blood...
June 22, 2017: Fitoterapia
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