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https://www.readbyqxmd.com/read/29049953/biomimetic-fabrication-of-antibacterial-calcium-phosphates-mediated-by-polydopamine
#1
Lucia Forte, Paola Torricelli, Francesca Bonvicini, Elisa Boanini, Giovanna Angela Gentilomi, Gigliola Lusvardi, Elena Della Bella, Milena Fini, Edoardo Vecchio Nepita, Adriana Bigi
In this work we developed new antibacterial composite materials using polydopamine (PDA) to trigger the deposition of silver nanoparticles (AgNPs) onto calcium phosphates, namely octacalcium phosphate (OCP) and α-tricalcium phosphate (αTCP). Functionalization of OCP and αTCP with a self-polymerized polydopamine layer was obtained by soaking the calcium phosphates in dopamine solution. The PDA surface of functionalized calcium phosphates (OCPd and αTCPd) promoted the deposition of AgNPs by reducing silver ions when soaked in a silver nitrate solution...
October 10, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/29049940/photocatalytic-degradation-of-synthetic-food-dye-sunset-yellow-fcf-fd-c-yellow-no-6-by-ailanthus-excelsa-roxb-possessing-antioxidant-and-cytotoxic-activity
#2
Subramanyam Deepika, Rajendran Harishkumar, Murugesan Dinesh, Rajadurai Abarna, Moorthy Anbalagan, Selvaraj Mohana Roopan, Chinnadurai Immanuel Selvaraj
The purpose of our work is to identify the bioactive compounds of bark and leaves extract from Ailanthus excelsa Roxb. and to explore its effectiveness against synthetic food dye. The presence of primary and secondary metabolites was confirmed by carrying out phytochemicals analysis. With the prior knowledge accessible on the indispensable secondary metabolites holding antioxidant and cytotoxicity activity, the quantitative screening of total phenolic and flavonoid content in methanolic and aqueous extract of bark and leaves from Ailanthus excelsa were done...
October 12, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29049874/balancing-bacteria-osteoblasts-competition-through-selective-physical-puncture-and-biofunctionalization-of-zno-polydopamine-arginine-glycine-aspartic-acid-cysteine-nanorods
#3
Jun Li, Lei Tan, Xiangmei Liu, Zhenduo Cui, Xianjin Yang, Kelvin Wai Kwok Yeung, Paul K Chu, Shuilin Wu
Bacterial infection and lack of bone tissue integration are two major concerns of orthopedic implants. In addition, osteoinductivity often decreases and toxicity may arise when antibacterial agents are introduced to increase the antibacterial ability. Here hybrid ZnO/polydopamine (PDA)/arginine-glycine-aspartic acid-cysteine (RGDC) nanorod (NR) arrays are designed and prepared on titanium (Ti) implants to not only enhance the osteoinductivity but also effectively kill bacteria simultaneously, which are ascribed to the selective physical puncture and the biofunctionalization of ZnO/PDA/RGDC nanorods during the competition between bacteria and osteoblasts, that is, owing to the much larger size of osteoblasts than bacteria, the hybrid NRs can puncture bacteria but not damage osteoblasts...
October 19, 2017: ACS Nano
https://www.readbyqxmd.com/read/29049642/antibacterial-inhibits-resistance
#4
Rebecca Voelker
No abstract text is available yet for this article.
October 17, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29048870/daptomycin-pore-formation-is-restricted-by-membrane-lipid-acyl-chain-composition
#5
Robert M Taylor, David Beriashvili, Scott D Taylor, Michael Palmer
Daptomycin is a calcium-dependent lipopeptide antibiotic that is used clinically against various Gram-positive pathogens. It acts on bacterial cell membranes, whose susceptibility varies with the content of phosphatidylglycerol (PG). Some studies have reported that daptomycin permeabilizes and depolarizes bacterial cell membranes, while others have found no evidence of membrane permeabilization and thus proposed different mechanisms of antibacterial action. Divergent observations have also been reported regarding the effect of daptomycin on model membranes, which were found to be permeabilized non-selectively, selectively for small cations, or not at all...
October 19, 2017: ACS Infectious Diseases
https://www.readbyqxmd.com/read/29046846/bi-layer-sandwich-film-for-antibacterial-catheters
#6
Gerhard Franz, Florian Schamberger, Hamideh Heidari Zare, Sara Felicitas Bröskamp, Dieter Jocham
Background: Approximately one quarter of all nosocomial infections can be attributed to the urinary tract. The infections are supposed to be mainly caused by implantations of urethral catheters and stents. A new catheter design is introduced with the aim to lower the high number of nosocomial urethral infections. In order to avoid limitations to use, the design is first applied to conventional commercially available balloon catheters. Results: The main feature of the design is a sandwich layer on both sides of the catheter wall, which is composed of a fragmented base layer of silver capped by a thin film of poly(p-xylylene)...
2017: Beilstein Journal of Nanotechnology
https://www.readbyqxmd.com/read/29046693/antibacterial-activity-of-essential-oil-from-lavender-lavandula-angustifolia-against-pet-turtle-borne-pathogenic-bacteria
#7
Sabrina Hossain, Honghoi Heo, B C J De Silva, S H M P Wimalasena, H N K S Pathirana, Gang-Joon Heo
Pet turtles are well-known to harbor an array of bacterial pathogens which can cause zoonotic infections in humans as well as opportunistic infections in the turtles itself. Essential oils are the natural plant extracts which have been traditionally used for disease treatment. In the present study, the essential oil of lavender (EOL) was examined for its antibacterial activity against thirty-eight strains of turtle-borne pathogenic bacteria belonging to seven species; Aeromonas hydrophila, A. caviae, A. dhakensis, Citrobacter freundii, Proteus mirabilis, Salmonella enterica and Pseudomonas aeruginosa...
September 2017: Laboratory Animal Research
https://www.readbyqxmd.com/read/29046668/characterization-of-anti-bacterial-compounds-from-the-seed-coat-of-chinese-windmill-palm-tree-trachycarpus-fortunei
#8
Shakeel Ahmed, Huimin Liu, Aqeel Ahmad, Waheed Akram, Eman K N Abdelrahman, Fengming Ran, Wuling Ou, Shuang Dong, Qian Cai, Qiyun Zhang, Xiaohua Li, Sheng Hu, Xuebo Hu
The increasing of multidrug resistance in bacterial associated infections has impaired the current antimicrobial therapy and it forces the search for other alternatives. In this study, we aimed to find the in vitro antibacterial activity of seed coat of Trachycarpus fortunei against a panel of clinically important bacterial species. Ethanolic extracts of target tissues were fractionated through macro porous resin by column chromatography, using ethanol as an organic solvent with a concentration gradient of 0-100%, each along with 20% concentration increment...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29046368/enhancement-of-lung-gene-delivery-after-aerosol-a-new-strategy-using-non-viral-complexes-with-antibacterial-properties
#9
Angelique Mottais, Tony Le Gall, Yann Sibiril, Julian Ravel, Véronique Laurent, Frédérique d'Arbonneau, Tristan Montier
The pathophysiology of obstructive pulmonary diseases, such as cystic fibrosis, leads to the development of chronic infections in the respiratory tract. Thus, the symptomatic management of the disease requires, in particular, repetitive antibiotherapy. Besides these antibacterial treatments, certain pathologies, such as cystic fibrosis or chronic obstructive pulmonary disease, require the intake of many drugs. This simultaneous absorption may lead to undesired drug interactions. For example, Orkambi® (lumacaftor/Ivacaftor, Vertex), a pharmacological drug employed to treat F508del patients, cannot be used with antibiotics such as rifampicin or rifabutin (rifamycin family) which are necessary to treat Mycobacteriaceae...
October 18, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/29045929/deciphering-the-complexation-process-of-a-fluoroquinolone-antibiotic-levofloxacin-with-bovine-serum-albumin-in-the-presence-of-additives
#10
Amandeep Kaur, Imran Ahmd Khan, Parampaul Kaur Banipal, Tarlok Singh Banipal
The current work aims to explore the thermodynamic and conformational aspects for the binding of fluoroquinolone antibacterial drug, levofloxacin (LFC), with bovine serum albumin (BSA) using calorimetric, spectroscopic (UV-visible, fluorescence, circular dichroism, and (1)H NMR), dynamic light scattering (DLS) and computational methods (molecular docking). The binding of LFC with BSA at two sequential sites with higher affinity (~10(3)M(-1)) at the first site has been explored by calorimetry whereas the binding at a single site with affinity of the order of ~10(4)M(-1) has been observed from fluorescence spectroscopy...
October 9, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29045862/the-two-state-prehensile-tail-of-the-antibacterial-toxin-colicin-n
#11
Christopher L Johnson, Alexandra S Solovyova, Olli Hecht, Colin Macdonald, Helen Waller, J Günter Grossmann, Geoffrey R Moore, Jeremy H Lakey
Intrinsically disordered regions within proteins are critical elements in many biomolecular interactions and signaling pathways. Antibacterial toxins of the colicin family, which could provide new antibiotic functions against resistant bacteria, contain disordered N-terminal translocation domains (T-domains) that are essential for receptor binding and the penetration of the Escherichia coli outer membrane. Here we investigate the conformational behavior of the T-domain of colicin N (ColN-T) to understand why such domains are widespread in toxins that target Gram-negative bacteria...
October 17, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/29045805/triclocarban-enhances-short-chain-fatty-acids-production-from-anaerobic-fermentation-of-waste-activated-sludge
#12
Yali Wang, Dongbo Wang, Yiwen Liu, Qilin Wang, Fei Chen, Qi Yang, Xiaoming Li, Guangming Zeng, Hailong Li
Triclocarban (TCC), one typical antibacterial agent being widely used in various applications, was found to be present in waste activated sludge at significant levels. To date, however, its effect on anaerobic fermentation of sludge has not been investigated. This work therefore aims to fill this knowledge gap. Experimental results showed that when TCC content in sludge increased from 26.7 ± 5.3 to 520.5 ± 12.6 mg per kilogram total suspended solids, the maximum concentration of short-chain fatty acids (SCFA) increased from 32...
October 6, 2017: Water Research
https://www.readbyqxmd.com/read/29045123/polymyxin-b3-tobramycin-hybrids-with-pseudomonas-aeruginosa-selective-antibacterial-activity-and-strong-potentiation-of-rifampicin-minocycline-and-vancomycin
#13
Ronald Domalaon, Xuan Yang, Yinfeng Lyu, George G Zhanel, Frank M Schweizer
There is an urgent need to develop novel antibacterial agents able to eradicate drug-resistant Gram-negative pathogens such as Pseudomonas aeruginosa. Antimicrobial hybrids have emerged as a promising strategy to combat bacterial resistance, as a stand-alone drug but also as an adjuvant in combination with existing antibiotics. Herein, we report for the first time the synthesis and biological evaluation of polymyxin-aminoglycoside heterodimers composing of polymyxin B3 covalently linked to tobramycin via an aliphatic hydrocarbon linker...
October 18, 2017: ACS Infectious Diseases
https://www.readbyqxmd.com/read/29044318/antibiotic-activity-of-plectranthus-ornatus-codd-a-traditional-medicinal-plant
#14
Fernanda R Nascimento, Kamylla R S Albuquerque, Marcos R Oliveira, Virginia R Pizziolo, Beatriz G Brasileiro, Gaspar Diaz, Marisa A N Diaz
The dichloromethane extract of Plectranthus ornatus Codd., a tradicional medicinal plant, showed antibiotic activity with minimum inhibitory concentration (MIC) values of 0.4 mg.mL-1 and 100 percent of biofilm inhibition against Staphylococcus aureus strains isolated from animals with mastitis infections. Based on these antibacterial activities, in addition to ethnopharmacological reports from healing men and farmers in Brazil, an herbal soap was produced from this active extract and was tested both in vitro and in vivo...
October 16, 2017: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/29043959/purified-citritin-in-combination-with-vancomycin-inhibits-vre-in-vitro-and-in-vivo
#15
Kléber de Sousa Oliveira, Paulo Roberto Martins Queiroz, Isabel Cristina Marques Fensterseifer, Ludovico Migliolo, Aline Lima Oliveira, Octávio Luiz Franco
Gram-positive pathogens such as methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecium (VRE) have been frequently associated with bacterial resistance mechanisms. These mechanisms, in turn, restrict a range of therapeutic opportunities for the treatment of infections caused by these micro-organisms. Faced with this problem, the present study aims to isolate and characterize molecules with antimicrobial activity derived from the fungus Penicillium citrinum isolated from Cerrado soil...
October 18, 2017: Microbiology
https://www.readbyqxmd.com/read/29043602/fluorinated-pyrrole-incorporated-2-thiazolyl-hydrazone-motifs-a-new-class-of-antimicrobial-and-anti-tuberculosis-agents
#16
P V Sowmya, Boja Poojary, Vasantha Kumar, U Vishwanatha, Premalatha Shetty
In aim of obtaining novel bio-active compounds, a new series of fluorinated 1-(4-(aryl)thiazol-2-yl)-2-((1-(aryl)-2,5-dimethyl-1H-pyrrol-3-yl)methylene)hydrazines (5a-t) and 1-(4-(4-aryl)thiazol-2-yl)-2-((3-(2,4-dichlorophenyl)-1-phenyl-1H-pyrazol-4-yl)methylene)hydrazines (8a-d) were synthesized and screened for their antibacterial and antifungal activities. The potent compounds were further screened in vitro for anti-tuberculosis activity against Mycobacterium tuberculosis H37Rv strain. Compounds 5a, 5c-5h and 5m were found to be good inhibitors of B...
October 17, 2017: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/29043494/influence-of-proline-substitution-on-the-bioactivity-of-mammalian-derived-antimicrobial-peptide-nk-2
#17
Jiexi Yan, Xiaolei Liang, Chang Liu, Yuemei Cheng, Lanxia Zhou, Kairong Wang, Li Zhao
Multidrug-resistant bacteria are emerging as a global threat, making the search for alternative compounds urgent. Antimicrobial peptides (AMPs) became a promising hotspot due to their distinct action mechanism and possibility to be used as an alternative or complement to traditional antibiotics. However, gaining a better understanding about the relationship between antimicrobial peptides structure and its bioactivity is crucial for the development of next generation of antimicrobial agents. NK-2, derived from mammalian protein NK-lysin, has potent antitumor and bactericidal abilities...
October 17, 2017: Probiotics and Antimicrobial Proteins
https://www.readbyqxmd.com/read/29043249/interactions-between-bacteria-and-bile-salts-in-the-gastrointestinal-and-hepatobiliary-tracts
#18
REVIEW
Verónica Urdaneta, Josep Casadesús
Bile salts and bacteria have intricate relationships. The composition of the intestinal pool of bile salts is shaped by bacterial metabolism. In turn, bile salts play a role in intestinal homeostasis by controlling the size and the composition of the intestinal microbiota. As a consequence, alteration of the microbiome-bile salt homeostasis can play a role in hepatic and gastrointestinal pathological conditions. Intestinal bacteria use bile salts as environmental signals and in certain cases as nutrients and electron acceptors...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/29043212/antibacterial-anti-diarrhoeal-analgesic-cytotoxic-activities-and-gc-ms-profiling-of-sonneratia-apetala-buch-ham-seed
#19
Sheikh Julfikar Hossain, M Rabiul Islam, Tahmina Pervin, M Iftekharuzzaman, Omer A A Hamdi, Sanzida Mubassara, M Saifuzzaman, Jamil Ahmad Shilpi
Fruits of Sonneratia apetala (Buch.-Ham.), (English: mangrove apple, Bengali: keora) both seeds and pericarps, are largely consumed as food besides their enormous medicinal application. The fruit seeds have high content of nutrients and bioactive components. The seeds powder of S. apetala was successively fractionated using n-hexane, diethyl ether, chloroform, ethyl acetate, and methanol. The fractions were used to evaluate antibacterial, anti-diarrhoeal, analgesic, and cytotoxic activities. Methanol fraction of seeds (MeS) stronly inhibited Escherichia coli strains, Salmonella Paratyphi A, Salmonella Typhi, Shigella dysenteriae, and Staphylococcus aureus except Vibrio cholerae at 500 μg/disc...
September 2017: Preventive Nutrition and Food Science
https://www.readbyqxmd.com/read/29042450/zinc-finger-protein-365-is-a-new-maternal-lps-binding-protein-that-defends-zebrafish-embryos-against-gram-negative-bacterial-infections
#20
Xiaoyuan Du, Yang Zhou, Lili Song, Xia Wang, Shicui Zhang
Zinc finger protein 365 (ZNF365) is widespread in animals, but its function and mechanism remains poorly defined. Here we clearly demonstrate that zebrafish ZNF365 is a newly identified LPS-binding protein capable of interacting with the gram-negative bacteria Escherichia coli, Vibrio anguillarum, and Aeromonas hydrophila, and functions as an antibacterial effector molecule capable of directly killing the bacteria. We also reveal that N-terminal residues 30-55 consisting of the ZnF_C2H2 domain are indispensable for ZNF365 antimicrobial activity...
October 17, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
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