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Water fat imaging

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https://www.readbyqxmd.com/read/29670577/anatomical-variation-of-age-related-changes-in-vertebral-bone-marrow-composition-using-chemical-shift-encoding-based-water-fat-magnetic-resonance-imaging
#1
Thomas Baum, Alexander Rohrmeier, Jan Syväri, Maximilian N Diefenbach, Daniela Franz, Michael Dieckmeyer, Andreas Scharr, Hans Hauner, Stefan Ruschke, Jan S Kirschke, Dimitrios C Karampinos
Assessment of vertebral bone marrow composition has been proposed as imaging biomarker for osteoporosis, hematopoietic, and metabolic disorders. We investigated the anatomical variation of age-related changes of vertebral proton density fat fraction (PDFF) using chemical shift encoding-based water-fat magnetic resonance imaging (MRI). 156 healthy subjects were recruited (age range 20-29 years: 12/30 males/females; 30-39: 15/9; 40-49: 4/14; 50-59: 9/27; 60-69: 5/19; 70-79: 4/8). An eight-echo 3D spoiled gradient-echo sequence at 3T MRI was used for chemical shift-encoding based water-fat separation at the lumbar spine...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29657962/a-robust-method-for-estimating-b0-inhomogeneity-field-in-the-liver-by-mitigating-fat-signals-and-phase-wrapping
#2
Antonis Matakos, James M Balter, Yue Cao
We developed an optimized and robust method to estimate liver B0 field inhomogeneity for monitoring and correcting susceptibility-induced geometric distortion in magnetic resonance images for precision therapy. A triple-gradient-echo acquisition was optimized for the whole liver B0 field estimation within a single-exhale breath-hold scan on a 3 T scanner. To eliminate chemical-shift artifacts, fat signals were chosen in-phase between 2 echoes with an echo time difference (ΔTE) of 2.3 milliseconds. To avoid phase-wrapping, other 2 echoes provided a large field dynamic range (1/ΔTE) to cover the B0 field inhomogeneity...
June 2017: Tomography: a Journal for Imaging Research
https://www.readbyqxmd.com/read/29628974/the-effect-of-near-infrared-fluorescence-conjugation-on-the-anti-cancer-potential-of-cetuximab
#3
Ji Young Yun, Byung-Hwa Hyun, Sang Yoon Nam, Young Won Yun, Hu-Jang Lee, Beom-Jun Lee
This study investigated the anti-cancer potential of a near-infrared fluorescence (NIRF) molecule conjugated with Cetuximab (Cetuximab-NIRF) in six-week-old female BALB/c athymic (nu+/nu+) nude mice. A431 cells were cultured and injected into the animals to induce solid tumors. Paclitaxel (30 mg/kg body weight (BW)), Cetuximab (1 mg/kg BW), and Cetuximab-NIRF (0.25, 0.5 and 1.0 mg/kg BW) were intraperitoneally injected twice a week into the A431 cell xenografts of the nude mice. Changes in BW, tumor volume and weight, fat and lean mass, and diameter of the peri-tumoral blood vessel were determined after two weeks...
March 2018: Laboratory Animal Research
https://www.readbyqxmd.com/read/29613984/t2-weighted-dixon-turbo-spin-echo-for-accelerated-simultaneous-grading-of-whole-body-skeletal-muscle-fat-infiltration-and-edema-in-patients-with-neuromuscular-diseases
#4
Sarah Schlaeger, Elisabeth Klupp, Dominik Weidlich, Barbara Cervantes, Sarah C Foreman, Marcus Deschauer, Benedikt Schoser, Christoph Katemann, Hendrik Kooijman, Ernst J Rummeny, Claus Zimmer, Jan S Kirschke, Dimitrios C Karampinos
OBJECTIVE: The assessment of fatty infiltration and edema in the musculature of patients with neuromuscular diseases (NMDs) typically requires the separate performance of T1-weighted and fat-suppressed T2-weighted sequences. T2-weighted Dixon turbo spin echo (TSE) enables the generation of T2-weighted fat- and water-separated images, which can be used to assess both pathologies simultaneously. The present study examines the diagnostic performance of T2-weighted Dixon TSE compared with the standard sequences in 10 patients with NMDs and 10 healthy subjects...
April 2, 2018: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/29602018/low-dose-caffeine-as-a-salivary-tracer-for-the-determination-of-gastric-water-emptying-in-fed-and-fasted-state-a-mri-validation-study
#5
Maximilian Sager, Philipp Jedamzik, Simon Merdivan, Michael Grimm, Felix Schneider, Marie-Luise Kromrey, Mahmoud Hasan, Stefan Oswald, Jens Kühn, Mirko Koziolek, Werner Weitschies
Improving our knowledge about human gastrointestinal physiology and its impact on oral drug delivery is crucial for the development of new therapies and effective drug delivery systems. The aim of this study was to develop an in vivo tool to determine gastric emptying of water by administration of a caffeine as a tracer substance followed by subsequent saliva caffeine analysis. For this purpose, 35mg of caffeine were given to six healthy volunteers after a 10h overnight together with 240mL of tap water either on a fasted stomach or 30min after the high-caloric, high-fat breakfast recommended for bioavailability/bioequivalence (BA/BE) studies...
March 27, 2018: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29601865/water-fat-separation-incorporating-spatial-smoothing-is-robust-to-noise
#6
Jonathan Andersson, Håkan Ahlström, Joel Kullberg
PURPOSE: To develop and evaluate a noise-robust method for reconstruction of water and fat images for spoiled gradient multi-echo sequences. METHODS: The proposed method performs water-fat separation by using a graph cut to minimize an energy function consisting of unary and binary terms. Spatial smoothing is incorporated to increase robustness to noise. The graph cut can fail to find a solution covering the entire image, in which case the relative weighting of the unary term is iteratively increased until a complete solution is found...
March 27, 2018: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29594090/assessing-exposures-to-magnetic-resonance-imaging-s-complex-mixture-of-magnetic-fields-for-in-vivo-in-vitro-and-epidemiologic-studies-of-health-effects-for-staff-and-patients
#7
Jennifer Frankel, Jonna Wilén, Kjell Hansson Mild
A complex mixture of electromagnetic fields is used in magnetic resonance imaging (MRI): static, low-frequency, and radio frequency magnetic fields. Commonly, the static magnetic field ranges from one to three Tesla. The low-frequency field can reach several millitesla and with a time derivative of the order of some Tesla per second. The radiofrequency (RF) field has a magnitude in the microtesla range giving rise to specific absorption rate values of a few Watts per kilogram. Very little attention has been paid to the case where there is a combined exposure to several different fields at the same time...
2018: Frontiers in Public Health
https://www.readbyqxmd.com/read/29566449/quantitative-susceptibility-mapping-qsm-minimizes-interference-from-cellular-pathology-in-r2-estimation-of-liver-iron-concentration
#8
Jianqi Li, Huimin Lin, Tian Liu, Zhuwei Zhang, Martin R Prince, Kelly Gillen, Xu Yan, Qi Song, Ting Hua, Xiance Zhao, Miao Zhang, Yu Zhao, Gaiying Li, Guangyu Tang, Guang Yang, Gary M Brittenham, Yi Wang
BACKGROUND: A challenge for R2 and R2* methods in measuring liver iron concentration (LIC) is that fibrosis, fat, and other hepatic cellular pathology contribute to R2 and R2* and interfere with LIC estimation. PURPOSE: To examine the interfering effects of fibrosis, fat, and other lesions on R2* LIC estimation and to use quantitative susceptibility mapping (QSM) to reduce these distortions. STUDY TYPE: Prospective. PHANTOMS, SUBJECTS: Water phantoms with various concentrations of gadolinium (Gd), collagen (Cl, modeling fibrosis), and fat; nine healthy controls with no known hepatic disease, nine patients with known or suspected hepatic iron overload, and nine patients with focal liver lesions...
March 22, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29545214/hybrid-quantitative-mri-using-chemical-shift-displacement-and-recovery-based-simultaneous-water-and-lipid-imaging-a-preliminary-study
#9
Naoki Ohno, Tosiaki Miyati, Shuto Suzuki, Hirohito Kan, Toshitaka Aoki, Yoshitaka Nakamura, Yuki Hiramatsu, Satoshi Kobayashi, Toshifumi Gabata
PURPOSE: To suppress olefinic signals and enable simultaneous and quantitative estimation of multiple functional parameters associated with water and lipid, we investigated a modified method using chemical shift displacement and recovery-based separation of lipid tissue (SPLIT) involving acquisitions with different inversion times (TIs), echo times (TEs), and b-values. MATERIALS AND METHODS: Single-shot diffusion echo-planar imaging (SSD-EPI) with multiple b-values (0-3000 s/mm2 ) was performed without fat suppression to separate water and lipid images using the chemical shift displacement of lipid signals in the phase-encoding direction...
March 12, 2018: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29543692/-x-map-2-0-for-edema-signal-enhancement-for-acute-ischemic-stroke-using-non-contrast-enhanced-dual-energy-computed-tomography
#10
Katsuyuki Taguchi, Toshihide Itoh, Matthew K Fuld, Eric Fournie, Okkyun Lee, Kyo Noguchi
OBJECTIVES: A novel imaging technique ("X-map") has been developed to identify acute ischemic lesions for stroke patients using non-contrast-enhanced dual-energy computed tomography (NE-DE-CT). Using the 3-material decomposition technique, the original X-map ("X-map 1.0") eliminates fat and bone from the images, suppresses the gray matter (GM)-white matter (WM) tissue contrast, and makes signals of edema induced by severe ischemia easier to detect. The aim of this study was to address the following 2 problems with the X-map 1...
March 14, 2018: Investigative Radiology
https://www.readbyqxmd.com/read/29514074/non-invasive-measurement-of-brown-fat-metabolism-based-on-optoacoustic-imaging-of-hemoglobin-gradients
#11
Josefine Reber, Monja Willershäuser, Angelos Karlas, Korbinian Paul-Yuan, Gael Diot, Daniela Franz, Tobias Fromme, Saak V Ovsepian, Nicolas Bézière, Elena Dubikovskaya, Dimitrios C Karampinos, Christina Holzapfel, Hans Hauner, Martin Klingenspor, Vasilis Ntziachristos
Metabolism is a fundamental process of life. However, non-invasive measurement of local tissue metabolism is limited today by a deficiency in adequate tools for in vivo observations. We designed a multi-modular platform that explored the relation between local tissue oxygen consumption, determined by label-free optoacoustic measurements of hemoglobin, and concurrent indirect calorimetry obtained during metabolic activation of brown adipose tissue (BAT). By studying mice and humans, we show how video-rate handheld multi-spectral optoacoustic tomography (MSOT) in the 700-970 nm spectral range enables non-invasive imaging of BAT activation, consistent with positron emission tomography findings...
March 6, 2018: Cell Metabolism
https://www.readbyqxmd.com/read/29513377/quantitative-analysis-of-hepatic-iron-in-patients-suspected-of-coexisting-iron-overload-and-steatosis-using-multi-echo-single-voxel-magnetic-resonance-spectroscopy-comparison-with-fat-saturated-multi-echo-gradient-echo-sequence
#12
Huimin Lin, Caixia Fu, Stephan Kannengiesser, Shu Cheng, Jun Shen, Haipeng Dong, Fuhua Yan
BACKGROUND: The coexistence of hepatic iron and fat is common in patients with hyperferritinemia, which plays an interactive and aggressive role in the progression of diseases (fibrosis, cirrhosis, and hepatocellular carcinomas). PURPOSE: To evaluate a modified high-speed T2 -corrected multi-echo, single voxel spectroscopy sequence (HISTOV) for liver iron concentration (LIC) quantification in patients with hyperferritinemia, with simultaneous fat fraction (FF) estimation...
March 7, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29496516/magnetic-resonance-imaging-and-spectroscopy-evidence-of-efficacy-for-adrenal-and-gonadal-hormone-replacement-therapy-in-anorexia-nervosa
#13
Sridhar Vajapeyam, Kirsten Ecklund, Robert V Mulkern, Henry A Feldman, Jennifer M O'Donnell, Amy D DiVasta, Clifford J Rosen, Catherine M Gordon
PURPOSE: Dehydroepiandrosterone (DHEA)+estrogen/progestin therapy for adolescent girls with anorexia nervosa (AN) has the potential to arrest bone loss. The primary aim of this study was to test the effects of DHEA+estrogen/progestin therapy in adolescent girls with AN on bone marrow in the distal femur using magnetic resonance imaging (MRI) and spectroscopy. METHODS: Seventy adolescent girls with AN were enrolled in a double blind, randomized, placebo-controlled trial at two urban hospital-based programs...
February 26, 2018: Bone
https://www.readbyqxmd.com/read/29488251/time-resolved-contrast-enhanced-mr-angiography-with-single-echo-dixon-fat-suppression
#14
Eric G Stinson, Joshua D Trzasko, Norbert G Campeau, James F Glockner, John Huston, Phillip M Young, Stephen J Riederer
PURPOSE: Dixon-based fat suppression has recently gained interest for dynamic contrast-enhanced MRI, but multi-echo techniques require longer scan times and reduce temporal resolution compared to single-echo alternatives without fat suppression. The purpose of this work is to demonstrate accelerated single-echo Dixon imaging with high spatial and temporal resolution. THEORY AND METHODS: Real-valued water and fat images can be obtained from a single measurement if the shared initial phase and that due to ΔB0 are assumed known a priori...
February 27, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29477926/colorectal-intussusception-secondary-to-primary-rectal-melanoma-a-novel-case-report
#15
Colin McQuade, Peadar S Waters, Ciara O'Brien, Stephen Crowther, William Torreggiani, Dara O Kavanagh
INTRODUCTION: Intussusception in adults is a rare condition, accounting for just 5% of all cases. Approximately 50% of cases of large intestine intussusception occur due to a malignant neoplasm. We present here a novel case report of colo-rectal intussusception arising secondary to a primary rectal melanoma. PRESENTATION OF CASE: We present the case of an 85 year-old patient, who underwent a colonoscopy for investigation of weight loss and altered bowel habit. At colonoscopy, a pigmented polypoid mass was visualised in the upper third of the rectum...
February 14, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29469137/impact-of-food-structure-on-the-compatibility-of-heated-wpi-pectin-complexes-in-meat-dispersions
#16
Benjamin Zeeb, Vanessa Schöck, Nicole Schmid, Lisa Majer, Kurt Herrmann, Jörg Hinrichs, Jochen Weiss
Process-stable complexes composed of whey protein isolate (WPI) and sugar beet pectin have great potential as structuring agents or fat replacers in foods. The current study investigates the compatibility of heated WPI : pectin complexes in different meat matrices. Spreadable raw-fermented sausages and sliceable emulsion-type sausages were therefore manufactured containing biopolymer complexes with various WPI : pectin ratios r (2 : 1, 8 : 1). Macro- and microstructural properties of the meat dispersions were analyzed in terms of colour, texture, rheometry, sensory, and confocal laser scanning microscopy (CLSM) measurements...
February 22, 2018: Food & Function
https://www.readbyqxmd.com/read/29464718/technical-note-feasibility-of-mri-based-estimation-of-water-equivalent-path-length-to-detect-changes-in-proton-range-during-treatment-courses
#17
Jinsoo Uh, Matthew J Krasin, Chia-Ho Hua
PURPOSE: To evaluate the feasibility of using on-treatment magnetic resonance imaging (MRI) to detect proton range changes during treatment courses. METHODS: MRI-based virtual computed tomography (vCT) was generated to calculate water-equivalent path length (WEPL) at the distal surface of a clinical target volume. T2-weighted MR images with and without fat suppression were processed by thresholding and fuzzy c-mean clustering to assign a bulk HU (Hounsfield Unit) to each segment of fat, water, and air...
February 21, 2018: Medical Physics
https://www.readbyqxmd.com/read/29455909/elevated-tissue-sodium-deposition-in-patients-with-type-2-diabetes-on-hemodialysis-detected-by-23-na-magnetic-resonance-imaging
#18
Christoph Kopp, Peter Linz, Carolin Maier, Peter Wabel, Matthias Hammon, Armin M Nagel, Daniela Rosenhauer, Stephan Horn, Michael Uder, Friedrich C Luft, Jens Titze, Anke Dahlmann
Long-term elevated blood sugar levels result in tissue matrix compositional changes in patients with diabetes mellitus type 2 (T2DM). We hypothesized that hemodialysis patients with T2DM might accumulate more tissue sodium than control hemodialysis patients. To test this,23 Na magnetic resonance imaging (23 Na MRI) was used to estimate sodium in skin and muscle tissue in hemodialysis patients with or without T2DM. Muscle fat content was estimated by1 H MRI and tissue sodium content by23 Na MRI pre- and post-hemodialysis in ten hemodialysis patients with T2DM and in 30 matched control hemodialysis patients...
February 15, 2018: Kidney International
https://www.readbyqxmd.com/read/29450711/renal-fat-fraction-and-diffusion-tensor-imaging-in-patients-with-early-stage-diabetic-nephropathy
#19
Yuan-Cheng Wang, Yinglian Feng, Chun-Qiang Lu, Shenghong Ju
OBJECTIVE: To investigate the renal fat fraction and water molecular diffusion features in patients with early-stage DN using Dixon imaging and diffusion tensor imaging (DTI). METHODS: Sixty-one type 2 diabetics (normoalbuminuria: n = 40; microalbuminuria: n = 21) and 34 non-diabetic volunteers were included. All participants received three-point Dixon imaging and DTI using a 3.0-T magnetic resonance imager. The fat fraction [FF] and DTI features [fractional anisotropy (FA), apparent diffusion coefficient (ADC), tract counts and length from DTI tractography] were collected...
February 15, 2018: European Radiology
https://www.readbyqxmd.com/read/29448076/single-multi-echo-gre-acquisition-with-short-and-long-echo-spacing-for-simultaneous-quantitative-mapping-of-fat-fraction-b0-inhomogeneity-and-susceptibility
#20
Junmin Liu, Spencer D Christiansen, Maria Drangova
Multi-echo gradient echo (mGRE) sequences have been widely adapted in clinical and scientific practice for different purposes to their capability of performing Dixon MRI, generating multi-contrast images and extracting multi-parametric maps. This work aims to extend mGRE-based techniques for imaging whole head, where further technical developments are required due to the co-existence of fat and large B0 inhomogeneity in regions such as the skull base and neck. Specifically, bipolar mGRE data were acquired with a single sequence that contains both a short echo-spacing (ΔTE) echo train to capture water-fat and B0 phase shifts (for proton density fat-fraction (FF) and B0 mapping) and a longer ΔTE echo train (and long echo times) to capture subtle susceptibility variations and R2* information...
February 13, 2018: NeuroImage
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