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https://www.readbyqxmd.com/read/28423540/correlations-between-intravoxel-incoherent-motion-ivim-parameters-and-histological-findings-in-rectal-cancer-preliminary-results
#1
Alexey Surov, Hans Jonas Meyer, Anne-Kathrin Höhn, Curd Behrmann, Andreas Wienke, Rolf Peter Spielmann, Nikita Garnov
Our purpose was to correlate different intravoxel incoherent motion (IVIM), histopathological and clinical parameters in rectal cancer. 17 patients with histologically proven rectal cancer investigated on a 3.T device were included into the study. DWI was performed using a multi-slice single-shot echo-planar imaging sequence with b values of 0, 50, 200, 500 and 1000 s/mm.2 A polygonal region of interest was drawn within the tumors on every b image. The following parameters were retrieved from IVIM: apparent diffusion coefficient (ADC), true diffusion (D), pseudo diffusion coefficient (D*), perfusion factor (f), and relative perfusion f·D*...
March 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28419705/intravoxel-incoherent-motion-mri-for-the-differentiation-of-benign-intermediate-and-malignant-solid-soft-tissue-tumors
#2
Haijun Wu, Shuixing Zhang, Changhong Liang, Hui Liu, Yanhui Liu, Yingjie Mei, Hongjun Liu, Zaiyi Liu, Fangping Xu
PURPOSE: To determine the diagnostic potential of apparent diffusion coefficient (ADC) and intravoxel incoherent motion (IVIM)-derived parameters for the differentiation of benign, intermediate, and malignant solid soft-tissue tumors. MATERIALS AND METHODS: The Institutional Review Board approved this prospective study, and informed consent was obtained. IVIM imaging was performed in 64 patients including 44 benign, 6 intermediate, and 14 malignant solid soft-tissue tumors at 1...
April 17, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28412443/separating-blood-and-water-perfusion-and-free-water-elimination-from-diffusion-mri-in-the-human-brain
#3
Anna S Rydhög, Filip Szczepankiewicz, Ronnie Wirestam, André Ahlgren, Carl-Fredrik Westin, Linda Knutsson, Ofer Pasternak
The assessment of the free water fraction in the brain provides important information about extracellular processes such as atrophy and neuroinflammation in various clinical conditions as well as in normal development and aging. Free water estimates from diffusion MRI are assumed to account for freely diffusing water molecules in the extracellular space, but may be biased by other pools of molecules in rapid random motion, such as the intravoxel incoherent motion (IVIM) of blood, where water molecules perfuse in the randomly oriented capillary network...
April 12, 2017: NeuroImage
https://www.readbyqxmd.com/read/28410964/comparison-of-turbo-spin-echo-and-echo-planar-imaging-for-intravoxel-incoherent-motion-and-diffusion-tensor-imaging-of-the-kidney-at-3tesla
#4
Fabian Hilbert, Tobias Wech, Henning Neubauer, Simon Veldhoen, Thorsten Alexander Bley, Herbert Köstler
Echo Planar Imaging (EPI) is most commonly applied to acquire diffusion-weighted MR-images. EPI is able to capture an entire image in very short time, but is prone to distortions and artifacts. In diffusion-weighted EPI of the kidney severe distortions may occur due to intestinal gas. Turbo Spin Echo (TSE) is robust against distortions and artifacts, but needs more time to acquire an entire image compared to EPI. Therefore, TSE is more sensitive to motion during the readout. In this study we compare diffusion-weighted TSE and EPI of the human kidney with regard to intravoxel incoherent motion (IVIM) and diffusion tensor imaging (DTI)...
April 12, 2017: Zeitschrift Für Medizinische Physik
https://www.readbyqxmd.com/read/28383778/the-effect-of-noise-and-lipid-signals-on-determination-of-gaussian-and-non-gaussian-diffusion-parameters-in-skeletal-muscle
#5
Donnie Cameron, Mustapha Bouhrara, David A Reiter, Kenneth W Fishbein, Seongjin Choi, Christopher M Bergeron, Luigi Ferrucci, Richard G Spencer
This work characterizes the effect of lipid and noise signals on muscle diffusion parameter estimation in several conventional and non-Gaussian models, the ultimate objectives being to characterize popular fat suppression approaches for human muscle diffusion studies, to provide simulations to inform experimental work and to report normative non-Gaussian parameter values. The models investigated in this work were the Gaussian monoexponential and intravoxel incoherent motion (IVIM) models, and the non-Gaussian kurtosis and stretched exponential models...
April 6, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/28380018/image-denoising-substantially-improves-accuracy-and-precision-of-intravoxel-incoherent-motion-parameter-estimates
#6
Carolin Reischauer, Andreas Gutzeit
Applicability of intravoxel incoherent motion (IVIM) imaging in the clinical setting is hampered by the limited reliability in particular of the perfusion-related parameter estimates. To alleviate this problem, various advanced postprocessing methods have been introduced. However, the underlying algorithms are not readily available and generally suffer from an increased computational burden. Contrary, several computationally fast image denoising methods have recently been proposed which are accessible online and may improve reliability of IVIM parameter estimates...
2017: PloS One
https://www.readbyqxmd.com/read/28374076/selection-for-biopsy-of-kidney-transplant-patients-by-diffusion-weighted-mri
#7
Philipp Steiger, Sebastiano Barbieri, Anja Kruse, Michael Ith, Harriet C Thoeny
OBJECTIVES: To assess retrospectively whether diffusion-weighted magnetic resonance imaging (DW-MRI) allows physicians to determine the severity of histopathologic findings in biopsies of renal allograft patients with deteriorating renal function. METHODS: Forty consecutive kidney transplant patients underwent DW-MRI and biopsy. Patients were assigned to one group with severe and to another group with normal or mild histopathologic findings. These two groups were compared based on a qualitative DW-MRI assessment (homo-/heterogeneity) and the combination of qualitative and quantitative DW-MRI parameters (ADC, and intravoxel incoherent motion, IVIM, parameters: D, f, D*)...
April 3, 2017: European Radiology
https://www.readbyqxmd.com/read/28373765/chemotherapy-response-evaluation-in-a-mouse-model-of-gastric-cancer-using-intravoxel-incoherent-motion-diffusion-weighted-mri-and-histopathology
#8
Jin Cheng, Yi Wang, Chun-Fang Zhang, He Wang, Wei-Zhen Wu, Feng Pan, Nan Hong, Jie Deng
AIM: To determine the role of intravoxel incoherent motion (IVIM) diffusion-weighted (DW) magnetic resonance imaging (MRI) using a bi-exponential model in chemotherapy response evaluation in a gastric cancer mouse model. METHODS: Mice bearing MKN-45 human gastric adenocarcinoma xenografts were divided into four treated groups (TG1, 2, 3 and 4, n = 5 in each group) which received Fluorouracil and Calcium Folinate and a control group (CG, n = 7). DW-MRI scans with 14 b-values (0-1500 s/mm(2)) were performed before and after treatment on days 3, 7, 14 and 21...
March 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28370232/a-comparative-simulation-study-of-bayesian-fitting-approaches-to-intravoxel-incoherent-motion-modeling-in-diffusion-weighted-mri
#9
Peter T While
PURPOSE: To assess the performance of various least squares and Bayesian modeling approaches to parameter estimation in intravoxel incoherent motion (IVIM) modeling of diffusion-weighted MRI data. METHODS: Simulated tissue models of different type (breast/liver) and morphology (discrete/continuous) were used to generate noisy data according to the IVIM model at several signal-to-noise ratios. IVIM parameter maps were generated using six different approaches, including full nonlinear least squares (LSQ), segmented least squares (SEG), Bayesian modeling with a Gaussian shrinkage prior (BSP) and Bayesian modeling with a spatial homogeneity prior (FBM), plus two modified approaches...
March 31, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28349630/optimization-of-intra-voxel-incoherent-motion-measurement-in-diffusion-weighted-imaging-of-breast-cancer
#10
Wenjing Chen, Juan Zhang, Dan Long, Zhenchang Wang, Jian-Ming Zhu
PURPOSE: The purpose of this study was to optimize intra-voxel incoherent motion (IVIM) measurement in diffusion-weighted imaging (DWI) of breast cancer by separating perfusion and diffusion effects through the determination of an optimal threshold b-value, thus benign and cancerous breast tissues can be accurately differentiated using IVIM-derived diffusion and perfusion parameters. MATERIALS AND METHODS: Twenty-eight patients, with biopsy-confirmed breast cancers, were studied with a 3T MRI scanner, using T1-weighted dynamic contrast-enhanced MRI images, and diffusion-weighted images with nine b-values, ranging from 0 to 1000 s/mm²...
March 27, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28337521/evaluating-histologic-differentiation-of-hepatitis-b-virus-related-hepatocellular-carcinoma-using-intravoxel-incoherent-motion-and-afp-levels-alone-and-in-combination
#11
Qungang Shan, Jingbiao Chen, Tianhui Zhang, Ronghua Yan, Jun Wu, Yunhong Shu, Zhuang Kang, Bingjun He, Zhongping Zhang, Jin Wang
PURPOSE: To evaluate histologic differentiation of hepatitis B virus (HBV)-related hepatocellular carcinomas (HCCs) using apparent diffusion coefficient (ADC) and intravoxel incoherent motion (IVIM)-derived metrics and to compare findings with alpha-fetoprotein (AFP) levels alone and in combination. MATERIALS AND METHOD: One hundred and six chronic HBV-related HCC patients who underwent IVIM diffusion-weighted magnetic resonance imaging with eleven b values were enrolled...
March 24, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28332854/the-intravoxel-incoherent-motion-mri-of-lateral-pterygoid-muscle-a-quantitative-analysis-in-patients-with-temporomandibular-joint-disorders
#12
Supak Ngamsom, Shin Nakamura, Junichiro Sakamoto, Shinya Kotaki, Akemi Tetsumura, Tohru Kurabayashi
OBJECTIVES: To quantitatively evaluate diffusion and perfusion status of lateral pterygoid muscle (LPM) in patients with temporomandibular joint disorder (TMD) by intravoxel incoherent motion (IVIM) imaging and to correlate with findings on temporomandibular joints (TMJs) by conventional MRI. METHODS: 42 patients with TMD underwent MRI. To assess IVIM parameters, diffusion-weighted imaging was obtained by spin-echo-based single-shot echoplanar imaging. Regions of interest were created on all diffusion-weighted images of the superior belly of the lateral pterygoid (SLP) and inferior belly of the lateral pterygoid (ILP) at b-values 0-500 s mm(-2)...
March 23, 2017: Dento Maxillo Facial Radiology
https://www.readbyqxmd.com/read/28306208/evaluation-of-myocardial-microcirculation-using-intravoxel-incoherent-motion-imaging
#13
Anna Mou, Chen Zhang, Mengying Li, Fengqiang Jin, Qingwei Song, Ailian Liu, Zhiyong Li
PURPOSE: To explore whether cardiac magnetic resonance-intravoxel incoherent motion imaging (MR-IVIM) is feasible for the clinical evaluation of myocardial microcirculation. MATERIALS AND METHODS: The study included 30 patients (with hypertrophic cardiomyopathy, diabetes mellitus, hypertension, or combined diabetes and hypertension) and 34 healthy volunteers. MR-IVIM with a maximum gradient strength of 50 mT/m was performed on the left ventricular short axis (apex, middle, and base), using multiple b values (0-500 s/mm(2) ) on a 3...
March 17, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28283723/intravoxel-incoherent-motion-magnetic-resonance-imaging-of-the-knee-joint-in-children-with-juvenile-idiopathic-arthritis
#14
Fabian Hilbert, Annette Holl-Wieden, Alexander Sauer, Herbert Köstler, Henning Neubauer
BACKGROUND: MRI of synovitis relies on use of a gadolinium-based contrast agent. Diffusion-weighted MRI (DWI) visualises thickened synovium but is of limited use in the presence of joint effusion. OBJECTIVE: To investigate the feasibility and diagnostic accuracy of diffusion-weighted MRI with intravoxel incoherent motion (IVIM) for diagnosing synovitis in the knee joint of children with juvenile idiopathic arthritis. MATERIALS AND METHODS: Twelve consecutive children with confirmed or suspected juvenile idiopathic arthritis (10 girls, median age 11 years) underwent MRI with contrast-enhanced T1-weighted imaging and DWI at 1...
March 10, 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/28277457/advanced-mri-measures-of-cerebral-perfusion-and-their-clinical-applications
#15
Bryan Lanzman, Jeremy J Heit
Cerebral blood flow measurement by magnetic resonance imaging perfusion (MRP) techniques is broadly applied to patients with acute ischemic stroke, vasospasm following aneurysmal subarachnoid hemorrhage, chronic arterial steno-occlusive disease, cervical atherosclerotic disease, and primary brain neoplasms. MRP may be performed using an exogenous tracer, most commonly gadolinium-based intravenous contrast, or an endogenous tracer, such as arterial spin labeling (ASL) or intravoxel incoherent motion (IVIM). Here, we review the technical basis of commonly performed MRP techniques, the interpretation of MRP imaging maps, and how MRP provides valuable clinical information in the triage of patients with cerebral disease...
April 2017: Topics in Magnetic Resonance Imaging: TMRI
https://www.readbyqxmd.com/read/28276105/adctotal-ratio-and-d-ratio-derived-from-intravoxel-incoherent-motion-early-after-tace-are-independent-predictors-for-survival-in-hepatocellular-carcinoma
#16
Lifang Wu, Pengju Xu, Shengxiang Rao, Li Yang, Caizhong Chen, Hao Liu, Caixia Fu, Mengsu Zeng
PURPOSE: To explore the threshold of intravoxel incoherent motion (IVIM) parameters, apparent diffusion coefficient [ADCtotal and ADC(0,500) ] ratios 24-48 hours after transarterial chemoembolization (TACE) to assess early response in patients with unresectable hepatocellular carcinoma (HCC) and to compare the association between diffusion-weighted imaging with the intravoxel incoherent motion (IVIM-DWI) and mRECIST with survival. MATERIALS AND METHODS: Institutional Review Board approval and informed consent were obtained for this prospective study...
March 9, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28275560/liver-intravoxel-incoherent-motion-ivim-magnetic-resonance-imaging-a-comprehensive-review-of-published-data-on-normal-values-and-applications-for-fibrosis-and-tumor-evaluation
#17
REVIEW
Yáo T Li, Jean-Pierre Cercueil, Jing Yuan, Weitian Chen, Romaric Loffroy, Yì Xiáng J Wáng
A comprehensive literature review was performed on liver intravoxel incoherent motion (IVIM) magnetic resonance imaging (MRI) technique and its applications. Heterogeneous data have been reported. IVIM parameters are magnetic field strength dependent to a mild extent. A lower Dslow (D) value at 3 T than at 1.5 T and higher perfusion fraction (PF) value at 3 T than at 1.5 T were noted. An increased number of b values are associated with increased IVIM parameter measurement accuracy. With the current status of art, IVIM technique is not yet capable of detecting early stage liver fibrosis and diagnosing liver fibrosis grades, nor can it differentiate liver tumors...
February 2017: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/28269992/volumetric-analysis-of-intravoxel-incoherent-motion-imaging-for-assessment-of-solitary-pulmonary-lesions
#18
Mei Yuan, Yan Zhong, Yu-Dong Zhang, Tong-Fu Yu, Hai Li, Jiang-Fen Wu
Background Differentiating between malignant and benign solitary pulmonary lesions (SPLs) is challenging. Purpose To determine diagnostic performance of intravoxel incoherent motion-based diffusion-weighted imaging (DW-IVIM) in distinguishing malignant from benign SPLs, using histogram analysis derived whole-tumor and single-section region of interest (ROI). Material and Methods This retrospective study received institutional review board approval. A total of 129 patients with diagnosed SPLs underwent DW-IVIM and apparent diffusion coefficient (ADC)...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28267238/ultrahigh-b-values-mri-in-normal-human-prostate-initial-research-on-reproducibility-and-age-related-differences
#19
Changzheng Shi, Dong Zhang, Zeyu Xiao, Li Wang, Rong Ma, Hanwei Chen, Liangping Luo
PURPOSE: To investigate the reproducibility of diffusion-weighted imaging (DWI) with ultrahigh b-values, and analyze the age-related differences in normal prostates. MATERIALS AND METHODS: In all, 67 healthy participants were divided into three age groups (group A, 15-30 years; group B, 31-50 years; group C, ≥51 years), and underwent DWI scanning twice with 15 b-factors from 0 to 3000 at 3.0T. Triexponential fits were applied to calculate the molecular diffusion coefficient (D), the pseudo-diffusion coefficient (D*), the ultrahigh apparent diffusion coefficient (ADCuh ), and perfusion fraction (f)...
March 7, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28265697/intravoxel-incoherent-motion-diffusion-weighted-magnetic-resonance-imaging-of-focal-vertebral-bone-marrow-lesions-initial-experience-of-the-differentiation-of-nodular-hyperplastic-hematopoietic-bone-marrow-from-malignant-lesions
#20
Sunghoon Park, Kyu-Sung Kwack, Nam-Su Chung, Jinwoo Hwang, Hyun Young Lee, Jae Ho Kim
OBJECTIVE: To evaluate the ability of intravoxel incoherent motion (IVIM) diffusion-weighted magnetic resonance imaging (MRI) parameters to differentiate nodular hyperplastic hematopoietic bone marrow (HHBM) from malignant vertebral bone marrow lesions (VBMLs). MATERIALS AND METHODS: A total of 33 patients with 58 VBMLs, including 9 nodular HHBM lesions, 39 bone metastases, and 10 myelomas, were retrospectively assessed. All diagnoses were confirmed either pathologically or via image assessment...
March 6, 2017: Skeletal Radiology
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