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https://www.readbyqxmd.com/read/28714249/simultaneous-magnetic-resonance-diffusion-and-pseudo-diffusion-tensor-imaging
#1
Meghdoot Mozumder, Leandro Beltrachini, Quinten Collier, Jose M Pozo, Alejandro F Frangi
PURPOSE: An emerging topic in diffusion magnetic resonance is imaging blood microcirculation alongside water diffusion using the intravoxel incoherent motion (IVIM) model. Recently, a combined IVIM diffusion tensor imaging (IVIM-DTI) model was proposed, which accounts for both anisotropic pseudo-diffusion due to blood microcirculation and anisotropic diffusion due to tissue microstructures. In this article, we propose a robust IVIM-DTI approach for simultaneous diffusion and pseudo-diffusion tensor imaging...
July 16, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28708735/evaluation-and-minimization-of-the-pseudohepatic-anisotropy-artifact-in-liver-intravoxel-incoherent-motion
#2
Oi Lei Wong, Gladys Goh Lo, Jing Yuan, Wai Kit Chung, Wing Hung Benny Ho, Michael D Noseworthy
PURPOSE: The aim of this study was to evaluate the effect of the pseudohepatic anisotropy artifact on liver intravoxel incoherent motion (IVIM) metrics and whether the use of multiple gradient directions in the IVIM acquisition minimizes the artifact. MATERIALS AND METHODS: Multiple breath-holding and forced shallow free-breathing IVIM scans were performed on 8 healthy volunteers using 1 and 6 gradient directions. Cluster analysis was carried out to separate motion-contaminated parenchyma from liver parenchyma and vessels...
July 13, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28708726/measuring-cerebral-hypoperfusion-induced-by-hyperventilation-challenge-with-intravoxel-incoherent-motion-magnetic-resonance-imaging-in-healthy-volunteers
#3
Aude Pavilla, Alessandro Arrigo, Mehdi Mejdoubi, Régis Duvauferrier, Giulio Gambarota, Hervé Saint-Jalmes
OBJECTIVES: The aim of this study was to demonstrate the feasibility to assess cerebral hypoperfusion with a hyperventilation (HV) challenge protocol using intravoxel incoherent motion (IVIM) magnetic resonance imaging. MATERIALS AND METHODS: Magnetic resonance imaging experiments were performed on 10 healthy volunteers at 1.5 T, with a diffusion IVIM magnetic resonance imaging protocol using a set of b-values optimized by Cramer-Rao Lower Bound analysis. Hypoperfusion was induced by an HV maneuver...
July 13, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28703102/intravoxel-incoherent-motion-application-in-differentiation-of-hepatocellular-carcinoma-and-focal-nodular-hyperplasia
#4
Ma Luo, Ling Zhang, Xin Hua Jiang, Wei Dong Zhang
PURPOSE: We aimed to explore whether intravoxel incoherent motion (IVIM)-related parameters of hepatocellular carcinoma (HCC) and focal nodular hyperplasia (FNH) demonstrate differences that could be used to differentiate and improve diagnostic efficiency. METHODS: A total of 27 patients, including 22 with HCC and 5 with FNH, underwent liver 3.0 T magnetic resonance imaging for routine sequences. They were concurrently examined by IVIM diffusion-weighted imaging (DWI) scanning with 11 different b values (0-800 s/mm2)...
July 2017: Diagnostic and Interventional Radiology: Official Journal of the Turkish Society of Radiology
https://www.readbyqxmd.com/read/28677061/repeatability-of-apparent-diffusion-coefficient-and-intravoxel-incoherent-motion-parameters-at-3-0-tesla-in-orbital-lesions
#5
Augustin Lecler, Julien Savatovsky, Daniel Balvay, Mathieu Zmuda, Jean-Claude Sadik, Olivier Galatoire, Frédérique Charbonneau, Olivier Bergès, Hervé Picard, Laure Fournier
OBJECTIVES: To evaluate repeatability of intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI) parameters in the orbit. METHODS: From December 2015 to March 2016, 22 patients were scanned twice using an IVIM sequence with 15b values (0-2,000 s/mm(2)) at 3.0T. Two readers independently delineated regions of interest in an orbital mass and in different intra-orbital and extra-orbital structures. Short-term test-retest repeatability and inter-observer agreement were assessed using the intra-class correlation coefficient (ICC), the coefficient of variation (CV) and Bland-Altman limits of agreements (BA-LA)...
July 4, 2017: European Radiology
https://www.readbyqxmd.com/read/28677006/application-of-noninvasive-functional-imaging-to-monitor-the-progressive-changes-in-kidney-diffusion-and-perfusion-in-contrast-induced-acute-kidney-injury-rats-at-3-0-t
#6
Bin Zhang, Yuhao Dong, Baoliang Guo, Wenbo Chen, Fusheng Ouyang, Zhouyang Lian, Jing Liu, Shuixing Zhang
OBJECTIVES: Contrast-induced acute kidney injury is a prevalent cause of renal failure, and the noninvasive tools to monitor its progress are lacking. We applied intravoxel incoherent motion (IVIM) DWI to measure the progressive changes in kidney diffusion and perfusion of CI-AKI. METHODS: Twenty-four rats received Iopromide (370 mg/ml, 1600 mg iodine/kg) to induce CI-AKI. IVIM DWI was performed on rats (n = 6) at 24 h prior to and 12, 24, 48, 72, and 96 h after the injection using a 3...
July 4, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28674974/differentiating-radiation-necrosis-from-tumor-progression-in-brain-metastases-treated-with-stereotactic-radiotherapy-utility-of-intravoxel-incoherent-motion-perfusion-mri-and-correlation-with-histopathology
#7
Jay S Detsky, Julia Keith, John Conklin, Sean Symons, Sten Myrehaug, Arjun Sahgal, Chinthaka C Heyn, Hany Soliman
Radiation necrosis is a serious potential adverse event of stereotactic radiosurgery that cannot be reliably differentiated from recurrent tumor using conventional imaging techniques. Intravoxel incoherent motion (IVIM) is a magnetic resonance imaging (MRI) based method that uses a diffusion-weighted sequence to estimate quantitative perfusion and diffusion parameters. This study evaluated the IVIM-derived apparent diffusion coefficient (ADC) and perfusion fraction (f), and compared the results to the gold standard histopathological-defined outcomes of radiation necrosis or recurrent tumor...
July 3, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28669014/temporal-evolution-of-perfusion-parameters-in-brain-metastases-treated-with-stereotactic-radiosurgery-comparison-of-intravoxel-incoherent-motion-and-dynamic-contrast-enhanced-mri
#8
Anish Kapadia, Hatef Mehrabian, John Conklin, Sean P Symons, Pejman J Maralani, Greg J Stanisz, Arjun Sahgal, Hany Soliman, Chinthaka C Heyn
Intravoxel incoherent motion (IVIM) is a magnetic resonance imaging (MRI) technique that is seeing increasing use in neuro-oncology and offers an alternative to contrast-enhanced perfusion techniques for evaluation of tumor blood volume after stereotactic radiosurgery (SRS). To date, IVIM has not been validated against contrast enhanced techniques for brain metastases after SRS. In the present study, we measure blood volume for 20 brain metastases (15 patients) at baseline, 1 week and 1 month after SRS using IVIM and dynamic contrast enhanced (DCE)-MRI...
July 1, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28666091/a-combined-use-of-intravoxel-incoherent-motion-mri-parameters-can-differentiate-early-stage-hepatitis-b-fibrotic-livers-from-healthy-livers
#9
Yì Xiáng J Wáng, Min Deng, Yáo T Li, Hua Huang, Jason Chi Shun Leung, Weitian Chen, Pu-Xuan Lu
This study investigated a combined use of intravoxel incoherent motion (IVIM) parameters, Dslow ( D), PF ( f), and Dfast ( D*), for liver fibrosis evaluation. Sixteen healthy volunteers (F0) and 33 hepatitis-b patients (stage F1 = 15, stage F2-4 = 18) were included. With a 1.5 T MR scanner and respiration gating, IVIM diffusion-weighted imaging was acquired using a single-shot echo-planar imaging sequence with 10 b values of 10, 20, 40, 60, 80, 100, 150, 200, 400, and 800 s/mm(2). Signal measurement was performed on right liver parenchyma...
June 1, 2017: SLAS Technology
https://www.readbyqxmd.com/read/28653457/intravoxel-incoherent-motion-analysis-of-renal-allograft-diffusion-with-clinical-and-histopathological-correlation-in-pediatric-kidney-transplant-patients-a-preliminary-cross-sectional-observational-study
#10
Clare B Poynton, Marsha M Lee, Yi Li, Zoltan Laszik, Pauline W Worters, John D Mackenzie, Jesse Courtier
The purpose of this study was to compare IVIM values in pediatric renal transplants with histopathology and clinical management change. Fifteen pediatric renal transplant recipients (mean 15.7±2.9 years) were prospectively scanned on a 3T MR scanner with multi-b DTI, prior to same-day transplant biopsy. IVIM maps from 14 subjects were analyzed (one excluded due to motion). Mean values were computed from cortical ROIs and medullary ROIs corresponding to the biopsy site. Subjects were also grouped according to whether or not the biopsy resulted in a change in clinical management...
June 27, 2017: Pediatric Transplantation
https://www.readbyqxmd.com/read/28648123/value-of-intravoxel-incoherent-motion-in-assessment-of-pathological-grade-of-clear-cell-renal-cell-carcinoma
#11
Qingqiang Zhu, Jing Ye, Wenrong Zhu, Jingtao Wu, Wenxin Chen
Background Intravoxel incoherent motion (IVIM) can provide a unique view of tissue perfusion without the use of exogenous contrast agents. Purpose To investigate the value of IVIM in assessing grades of clear cell renal cell carcinoma (CRCC). Material and Methods A total of 107 patients with pathologically proven CRCC were included, 26 with grade I, 27 with grade II, 25 with grade III, and 29 with grade IV. These tumors were divided into low (I + II) and high grades (III + IV). Nine b values (0, 30, 50, 80, 150, 300, 500, 800, and 1500 s/mm(2)) were used in diffusion-weighted imaging (DWI)...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28643545/application-of-intravoxel-incoherent-motion-ivim-magnetic-resonance-imaging-in-the-evaluation-of-primitive-brain-tumours
#12
A Catanese, F Malacario, L Cirillo, F Toni, C Zenesini, D Casolino, A Bacci, R Agati
Intravoxel incoherent motion is a potential non-invasive diagnostic tool in brain tumours, without any clear guidelines for its evaluation yet. In our study, we compare intravoxel incoherent motion with dynamic susceptibility contrast magnetic resonance imaging in the quantification of tumour tissue blood perfusion in 28 patients affected by brain tumours, highlighting the issues encountered during the acquisition set-up and post-processing steps. Intravoxel incoherent motion is a new imaging tool and an alternative technique to dynamic susceptibility contrast-magnetic resonance imaging which is of considerable interest at present...
January 1, 2017: Neuroradiology Journal
https://www.readbyqxmd.com/read/28630864/intravoxel-incoherent-motion-diffusion-for-identification-of-breast-malignant-and-benign-tumors-using-chemometrics
#13
Fengnong Chen, Pulan Chen, Hamed Hamid Muhammed, Juan Zhang
The aim of the paper is to identify the breast malignant and benign lesions using the features of apparent diffusion coefficient (ADC), perfusion fraction f, pseudodiffusion coefficient D(⁎), and true diffusion coefficient D from intravoxel incoherent motion (IVIM). There are 69 malignant cases (including 9 early malignant cases) and 35 benign breast cases who underwent diffusion-weighted MRI at 3.0 T with 8 b-values (0~1000 s/mm(2)). ADC and IVIM parameters were determined in lesions. The early malignant cases are used as advanced malignant and benign tumors, respectively, so as to assess the effectiveness on the result...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28629565/a-tri-exponential-model-for-intravoxel-incoherent-motion-analysis-of-the-human-kidney-in-silico-and-during-pharmacological-renal-perfusion-modulation
#14
René van der Bel, Oliver J Gurney-Champion, Martijn Froeling, Erik S G Stroes, Aart J Nederveen, C T Paul Krediet
In the kidneys, there is both blood flow through the capillaries and flow of pre-urine through the tubuli and collecting ducts. We hypothesized that diffusion-weighted (DW) MRI measures both blood and pre-urine flow when using a tri-exponential intravoxel incoherent motion (IVIM) model. Our aim was to systematically investigate and optimize tri-exponential IVIM-analysis for the kidney and test its sensitivity to renal perfusion changes in humans. The tri-exponential fit probes the diffusion coefficient (D), the intermediate (D*i) and fast (D*f) pseudo-diffusion coefficients, and their signal fractions, fD, fi and ff...
June 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28626964/impact-of-prior-distributions-and-central-tendency-measures-on-bayesian-intravoxel-incoherent-motion-model-fitting
#15
Oscar Gustafsson, Mikael Montelius, Göran Starck, Maria Ljungberg
PURPOSE: Bayesian model fitting has been proposed as a robust alternative for intravoxel incoherent motion (IVIM) model-fitting parameter estimation. However, consensus regarding choice of prior distribution and posterior distribution central tendency measure is needed. The aim of this study was to compare the quality of IVIM parameter estimates produced by different prior distributions and central tendency measures, and to gain knowledge about the effect of these choices. METHODS: Three prior distributions (uniform, reciprocal, and lognormal) and two measures of central tendency (mean and mode) found in the literature were studied using simulations and in vivo data from a tumor mouse model...
June 19, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28624925/liver-fibrosis-in-vivo-evaluation-using-intravoxel-incoherent-motion-derived-histogram-metrics-with-histopathologic-findings-at-3-0-t
#16
Fubi Hu, Ru Yang, Zixing Huang, Min Wang, Hanmei Zhang, Xu Yan, Bin Song
PURPOSE: To retrospectively determine the feasibility of intravoxel incoherent motion (IVIM) imaging based on histogram analysis for the staging of liver fibrosis (LF) using histopathologic findings as the reference standard. METHODS: 56 consecutive patients (14 men, 42 women; age range, 15-76, years) with chronic liver diseases (CLDs) were studied using IVIM-DWI with 9 b-values (0, 25, 50, 75, 100, 150, 200, 500, 800 s/mm(2)) at 3.0 T. Fibrosis stage was evaluated using the METAVIR scoring system...
June 17, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28624026/the-prediction-of-the-treatment-response-of-cervical-nodes-using-intravoxel-incoherent-motion-diffusion-weighted-imaging
#17
Simona Marzi, Francesca Piludu, Giuseppe Sanguineti, Laura Marucci, Alessia Farneti, Irene Terrenato, Raul Pellini, Maria Benevolo, Renato Covello, Antonello Vidiri
PURPOSE: To investigate the predictive role of Intravoxel Incoherent Motion Diffusion-Weighted Imaging (IVIM-DWI) parameters on cervical nodal response to chemo-radiotherapy (CRT) of head and neck squamous cell carcinoma (HNSCC). MATERIALS AND METHODS: Patients with pathologically confirmed HNSCC were included in the present prospective study, having at least one positive cervical lymph node (LN). They received concomitant CRT and underwent three serial IVIM-DWI investigations: before, at mid-treatment and after treatment completion...
July 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28608327/diffusional-kurtosis-imaging-dki-incorporation-into-an-intravoxel-incoherent-motion-ivim-mr-model-to-measure-cerebral-hypoperfusion-induced-by-hyperventilation-challenge-in-healthy-subjects
#18
Aude Pavilla, Giulio Gambarota, Alessandro Arrigo, Mehdi Mejdoubi, Régis Duvauferrier, Hervé Saint-Jalmes
OBJECTIVES: The objectives were to investigate the diffusional kurtosis imaging (DKI) incorporation into the intravoxel incoherent motion (IVIM) model for measurements of cerebral hypoperfusion in healthy subjects. MATERIALS AND METHODS: Eight healthy subjects underwent a hyperventilation challenge with a 4-min diffusion weighted imaging protocol, using 8 b values chosen with the Cramer-Rao Lower Bound optimization approach. Four regions of interest in gray matter (GM) were analyzed with the DKI-IVIM model and the bi-exponential IVIM model, for normoventilation and hyperventilation conditions...
June 12, 2017: Magma
https://www.readbyqxmd.com/read/28604279/diffusion-and-intravoxel-incoherent-motion-mr-imaging-based-virtual-elastography-a-hypothesis-generating-study-in-the-liver
#19
Denis Le Bihan, Shintaro Ichikawa, Utaroh Motosugi
Purpose To investigate the potential of diffusion magnetic resonance (MR) imaging to provide quantitative estimates of tissue stiffness without using mechanical vibrations in patients with chronic liver diseases and to generate a new elasticity-driven intravoxel incoherent motion (IVIM) contrast. Materials and Methods This retrospective study, conducted from January to April 2016, was approved by an institutional review board that waived the requirement for informed consent. Fifteen subjects were included (13 men and two women; mean age ± standard deviation, 73 years ± 8)...
June 12, 2017: Radiology
https://www.readbyqxmd.com/read/28590780/intravoxel-incoherent-motion-and-dynamic-contrast-enhanced-mri-for-differentiation-between-hepatocellular-adenoma-and-focal-nodular-hyperplasia
#20
Naim Jerjir, Luk Bruyneel, Marc Haspeslagh, Sarah Quenet, Kenneth Coenegrachts
OBJECTIVES: To examine if intravoxel incoherent motion (IVIM) and dynamic contrast-enhanced MRI (DCE-MRI) can be used as new and supplemental MRI technique to differentiate hepatocellular adenomas (HCAs) from focal nodular hyperplasias (FNHs) and analyse if diffusion parameter ADC and IVIM parameter D differ in doing so. METHODS: This prospective study included 21 patients (8 HCAs and 13 FNHs) who underwent a specifically designed MRI scanning protocol, including series for analysis of IVIM (4 b-values 0, 10, 150 and 800 s/mm(2)) and DCE-MRI...
June 7, 2017: British Journal of Radiology
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