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https://www.readbyqxmd.com/read/29144153/intravoxel-incoherent-motion-diffusion-weighted-mr-imaging-for-differentiation-of-benign-and-malignant-musculoskeletal-tumors-at-3-t
#1
Hyun Kyong Lim, Won-Hee Jee, Joon-Yong Jung, Mun Young Paek, InSeong Kim, Chan-Kwon Jung, Yang-Guk Chung
OBJECTIVE: To evaluate the intravoxel incoherent motion (IVIM) diffusion-weighted (DW) magnetic resonance imaging (MRI) for differentiating between benign and malignant musculoskeletal tumors at 3 T. METHODS: Sixty-five patients with treatment-naïve musculoskeletal tumors (47 malignant and 23 benign lesions) who underwent 3 T MRI including IVIM DW imaging were included. IVIM-derived parameters included pure diffusion coefficient (D), perfusion related incoherent microcirculation (D*, pseudodiffusion coefficient), and perfusion fraction (f)...
November 16, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/29112516/intravoxel-incoherent-motion-analysis-of-abdominal-organs-application-of-simultaneous-multislice-acquisition
#2
Valerie Doan Phi Van, Anton S Becker, Alexander Ciritsis, Caecilia S Reiner, Andreas Boss
PURPOSE: The aim of this study was to systematically evaluate the accuracy of quantitative intravoxel incoherent motion (IVIM) analysis of the upper abdomen applying simultaneous multislice (SMS) diffusion-weighted imaging (DWI) to reduce acquisition time. MATERIALS AND METHODS: Diffusion-weighted imaging of parenchymal abdominal organs was performed in 8 healthy volunteers at 3 T using a standard DWI sequence (acceleration factor 1 [AF1]) and an SMS-accelerated echo planar imaging sequence with acceleration factors 2 and 3 (AF2/AF3)...
November 6, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/29110717/bayesian-intravoxel-incoherent-motion-parameter-mapping-in-the-human-heart
#3
Georg R Spinner, Constantin von Deuster, Kerem C Tezcan, Christian T Stoeck, Sebastian Kozerke
BACKGROUND: Intravoxel incoherent motion (IVIM) imaging of diffusion and perfusion in the heart suffers from high parameter estimation error. The purpose of this work is to improve cardiac IVIM parameter mapping using Bayesian inference. METHODS: A second-order motion-compensated diffusion weighted spin-echo sequence with navigator-based slice tracking was implemented to collect cardiac IVIM data in early systole in eight healthy subjects on a clinical 1.5 T CMR system...
November 6, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29110241/relative-enhanced-diffusivity-noise-sensitivity-protocol-optimization-and-the-relation-to-intravoxel-incoherent-motion
#4
Peter T While, Jose R Teruel, Igor Vidić, Tone F Bathen, Pål Erik Goa
OBJECTIVE: To explore the relationship between relative enhanced diffusivity (RED) and intravoxel incoherent motion (IVIM), as well as the impact of noise and the choice of intermediate diffusion weighting (b value) on the RED parameter. MATERIALS AND METHODS: A mathematical derivation was performed to cast RED in terms of the IVIM parameters. Noise analysis and b value optimization was conducted by using Monte Carlo calculations to generate diffusion-weighted imaging data appropriate to breast and liver tissue at three different signal-to-noise ratios...
November 6, 2017: Magma
https://www.readbyqxmd.com/read/29105178/is-there-evidence-for-more-than-two-diffusion-components-in-abdominal-organs-a-magnetic-resonance-imaging-study-in-healthy-volunteers
#5
Moritz C Wurnig, Manon Germann, Andreas Boss
The most commonly applied model for the description of diffusion-weighted imaging (DWI) data in perfused organs is bicompartmental intravoxel incoherent motion (IVIM) analysis. In this study, we assessed the ground truth of underlying diffusion components in healthy abdominal organs using an extensive DWI protocol and subsequent computation of apparent diffusion coefficient 'spectra', similar to the computation of previously described T2 relaxation spectra. Diffusion datasets of eight healthy subjects were acquired in a 3-T magnetic resonance scanner using 68 different b values during free breathing (equidistantly placed in the range 0-1005 s/mm(2) )...
November 3, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/29103979/comparison-of-microvascular-perfusion-evaluation-among-ivim-dwi-ct-perfusion-imaging-and-histological-microvessel-density-in-rabbit-liver-vx2-tumors
#6
Jing-Lei Li, Wei-Tao Ye, Zai-Yi Liu, Li-Fen Yan, Wei Luo, Xi-Ming Cao, Changhong Liang
OBJECT: To explore microcirculation features with intravoxel incoherent motion (IVIM) and to compare IVIM with CT perfusion imaging (CTPI) and microvessel density (MVD). MATERIALS AND METHODS: Hepatic CTPI and IVIM were performed in 16 rabbit liver VX2 tumor models. Hepatic arterial perfusion (HAP), hepatic arterial perfusion index (HPI), Blood flow (BF), and blood volume (BV) from CTPI were measured. Apparent diffusion coefficient (ADC), true diffusion coefficient (D), perfusion fraction (f), and pseudo-diffusion coefficient (D*) from IVIM were measured...
November 9, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29098732/differentiating-the-histologic-grades-of-gliomas-preoperatively-using-amide-proton-transfer-weighted-aptw-and-intravoxel-incoherent-motion-mri
#7
Tianyu Zou, Hao Yu, Chunxiu Jiang, Xianlong Wang, Shanshan Jiang, Qihong Rui, Yingjie Mei, Jinyuan Zhou, Zhibo Wen
The purpose of this work was to investigate the diagnostic performance of amide proton transfer-weighted (APTW) and intravoxel incoherent motion (IVIM) magnetic resonance imaging (MRI) in the preoperative grading of gliomas. Fifty-one patients with suspected gliomas were recruited and underwent a preoperative MRI examination that included APTW and IVIM sequences. All cases were confirmed by postsurgical histopathology. APTW signal intensity, true diffusion coefficient (D), perfusion fraction (f) and pseudo-diffusion coefficient (D*) were applied to assess the solid tumor component and contralateral normal-appearing white matter...
November 3, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/29095673/intravoxel-incoherent-motion-and-quantitative-non-gaussian-diffusion-mr-imaging-evaluation-of-the-diagnostic-and-prognostic-value-of-several-markers-of-malignant-and-benign-breast-lesions
#8
Mami Iima, Masako Kataoka, Shotaro Kanao, Natsuko Onishi, Makiko Kawai, Akane Ohashi, Rena Sakaguchi, Masakazu Toi, Kaori Togashi
Purpose To investigate the performance of integrated approaches that combined intravoxel incoherent motion (IVIM) and non-Gaussian diffusion parameters compared with the Breast Imaging and Reporting Data System (BI-RADS) to establish multiparameter thresholds scores or probabilities by using Bayesian analysis to distinguish malignant from benign breast lesions and their correlation with molecular prognostic factors. Materials and Methods Between May 2013 and March 2015, 411 patients were prospectively enrolled and 199 patients (allocated to training [n = 99] and validation [n = 100] sets) were included in this study...
November 2, 2017: Radiology
https://www.readbyqxmd.com/read/29075909/rapid-measurement-of-intravoxel-incoherent-motion-ivim-derived-perfusion-fraction-for-clinical-magnetic-resonance-imaging
#9
Emma M Meeus, Jan Novak, Hamid Dehghani, Andrew C Peet
OBJECTIVE: This study aimed to investigate the reliability of intravoxel incoherent motion (IVIM) model derived parameters D and f and their dependence on b value distributions with a rapid three b value acquisition protocol. MATERIALS AND METHODS: Diffusion models for brain, kidney, and liver were assessed for bias, error, and reproducibility for the estimated IVIM parameters using b values 0 and 1000, and a b value between 200 and 900, at signal-to-noise ratios (SNR) 40, 55, and 80...
October 26, 2017: Magma
https://www.readbyqxmd.com/read/29071436/measurement-and-scan-reproducibility-of-parameters-of-intravoxel-incoherent-motion-in-renal-tumor-and-normal-renal-parenchyma-a-preliminary-research-at-3-0%C3%A2-t-mr
#10
Jingjing Pan, Hongtao Zhang, Fengyuan Man, Yanguang Shen, Yingwei Wang, Yan Zhong, Lu Ma, Haiyi Wang, Huiyi Ye
PURPOSE: To prospectively estimate measurement and scan reproducibility of parameters of intravoxel incoherent motion (IVIM) in renal tumors, normal renal cortex, and medulla. METHODS: Twenty-four consecutive patients (twelve males and twelve females; median age 56.7 years, range 32-71 years) with 25 renal tumors (20 renal cell carcinomas, one urothelium carcinoma, three angiomyolipomas, and one oncocytoma) were examined twice using IVIM1 and IVIM2 with 9 and 16 b values, respectively, at 3...
October 25, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/29044896/support-vector-machine-for-breast-cancer-classification-using-diffusion-weighted-mri-histogram-features-preliminary-study
#11
Igor Vidić, Liv Egnell, Neil P Jerome, Jose R Teruel, Torill E Sjøbakk, Agnes Østlie, Hans E Fjøsne, Tone F Bathen, Pål Erik Goa
BACKGROUND: Diffusion-weighted MRI (DWI) is currently one of the fastest developing MRI-based techniques in oncology. Histogram properties from model fitting of DWI are useful features for differentiation of lesions, and classification can potentially be improved by machine learning. PURPOSE: To evaluate classification of malignant and benign tumors and breast cancer subtypes using support vector machine (SVM). STUDY TYPE: Prospective. SUBJECTS: Fifty-one patients with benign (n = 23) and malignant (n = 28) breast tumors (26 ER+, whereof six were HER2+)...
October 16, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29038934/characterisation-of-fibrosis-in-chemically-induced-rat-mammary-carcinomas-using-multi-modal-endogenous-contrast-mri-on-a-1-5t-clinical-platform
#12
Neil P Jerome, Jessica K R Boult, Matthew R Orton, James A d'Arcy, Ashutosh Nerurkar, Martin O Leach, Dow-Mu Koh, David J Collins, Simon P Robinson
OBJECTIVES: To determine the ability of multi-parametric, endogenous contrast MRI to detect and quantify fibrosis in a chemically-induced rat model of mammary carcinoma. METHODS: Female Sprague-Dawley rats (n=18) were administered with N-methyl-N-nitrosourea; resulting mammary carcinomas underwent nine-b-value diffusion-weighted (DWI), ultrashort-echo (UTE) and magnetisation transfer (MT) magnetic resonance imaging (MRI) on a clinical 1.5T platform, and associated quantitative MR parameters were calculated...
October 16, 2017: European Radiology
https://www.readbyqxmd.com/read/29034282/differentiation-of-prostate-cancer-lesions-in-the-transition-zone-by-diffusion-weighted-mri
#13
Jie Bao, Ximing Wang, Chunhong Hu, Jianquan Hou, Fenglin Dong, Lingchuan Guo
OBJECTIVE: To differentiate prostate cancer lesions in transition zone by diffusion-weighted-MRI (DW-MRI). METHODS: Data from a total of 63 patients who underwent preoperative DWI (b of 0-1000 s/mm(2)) were prospectively collected and processed by a monoexponential (DWI) model and compared with a biexponential (IVIM) model for quantitation of apparent diffusion coefficients (ADCs), perfusion fraction f, diffusivity D and pseudo-diffusivity D*. Histogram analyses were performed by outlining entire-tumor regions of interest (ROIs)...
2017: European Journal of Radiology Open
https://www.readbyqxmd.com/read/28981189/in-vivo-assessment-of-the-placental-anatomy-and-perfusion-in-a-mouse-model-of-intrauterine-inflammation
#14
Dan Wu, Jun Lei, Bei Jia, Han Xie, Yan Zhu, Jiadi Xu, Susumu Mori, Jiangyang Zhang, Irina Burd
BACKGROUND: Magnetic resonance imaging (MRI) provides useful markers to examine placental function. MRI features of placental injury due to intrauterine inflammation-a common risk during pregnancy, are not well known. PURPOSE: To investigate the capability of structural MRI and intravoxel incoherent motion (IVIM) imaging in examining acute placental injury in a mouse model of intrauterine inflammation, as well as gestation-dependent placental changes. STUDY TYPE: Prospective study...
October 5, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28978131/intravoxel-incoherent-motion-mr-imaging-in-nasopharyngeal-carcinoma-comparison-and-correlation-with-dynamic-contrast-enhanced-mr-imaging
#15
Vincent Lai, Victor Ho Fun Lee, Ka On Lam, Bingsheng Huang, Queenie Chan, Pek Lan Khong
OBJECTIVES: To compare accuracy and assess agreement between intravoxel incoherent motion (IVIM) magnetic resonance (MR) perfusion-related parameters and quantitative dynamic contrast-enhanced (DCE) MR parameters in nasopharyngeal carcinoma (NPC). RESULTS: D, f, D*, K(trans) , Kep and Vp were significantly lower in the high stage group while Ve was significantly higher in the high stage group. Optimal cut-off values were: D=0.749 × 10(-3) mm(2)/s; f=0.145; D*=100...
September 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28974131/assessment-of-human-placental-perfusion-by-intravoxel-incoherent-motion-mr-imaging
#16
Nathalie Siauve, Pierre Humbert Hayot, Benjamin Deloison, Gihad E Chalouhi, Marianne Alison, Daniel Balvay, Laurence Bussières, Olivier Clément, Laurent J Salomon
PURPOSE: To provide functional information on the human placenta, including perfusion, and diffusion, with no contrast agent injection, and to study correlations between intravoxel incoherent motion (IVIM) placental parameters and fetal growth. MATERIALS AND METHODS: MRI was performed in women undergoing legal termination of pregnancy at 17-34 weeks, including a 4-b-value and 11-b-value DW sequences. The apparent diffusion coefficient (ADC), the restricted diffusion coefficient (D), the pseudoperfusion coefficient (D*), and the perfusion fraction (f) were calculated...
October 3, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28960549/diffusion-parameter-mapping-with-the-combined-intravoxel-incoherent-motion-and-kurtosis-model-using-artificial-neural-networks-at-3%C3%A2-t
#17
Marco Bertleff, Sebastian Domsch, Sebastian Weingärtner, Jascha Zapp, Kieran O'Brien, Markus Barth, Lothar R Schad
Artificial neural networks (ANNs) were used for voxel-wise parameter estimation with the combined intravoxel incoherent motion (IVIM) and kurtosis model facilitating robust diffusion parameter mapping in the human brain. The proposed ANN approach was compared with conventional least-squares regression (LSR) and state-of-the-art multi-step fitting (LSR-MS) in Monte-Carlo simulations and in vivo in terms of estimation accuracy and precision, number of outliers and sensitivity in the distinction between grey (GM) and white (WM) matter...
September 28, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/28947842/semi-automatic-segmentation-of-the-placenta-into-fetal-and-maternal-compartments-using-intravoxel-incoherent-motion-mri
#18
Wonsang You, Nickie Andescavage, Zungho Zun, Catherine Limperopoulos
Intravoxel incoherent motion (IVIM) magnetic resonance imaging is an emerging non-invasive technique that has been recently applied to quantify in vivo global placental perfusion. We propose a robust semi-automated method for segmenting the placenta into fetal and maternal compartments from IVIM data, using a multi-label image segmentation algorithm called 'GrowCut'. Placental IVIM data were acquired on a 1.5T scanner from 16 healthy pregnant women between 21-37 gestational weeks. The voxel-wise perfusion fraction was then estimated after non-rigid image registration...
March 2017: Proceedings of SPIE
https://www.readbyqxmd.com/read/28940646/chronic-kidney-disease-pathological-and-functional-evaluation-with-intravoxel-incoherent-motion-diffusion-weighted-imaging
#19
Wei Mao, Jianjun Zhou, Mengsu Zeng, Yuqin Ding, Lijie Qu, Caizhong Chen, Xiaoqiang Ding, Yaqiong Wang, Caixia Fu
BACKGROUND: Because chronic kidney disease (CKD) is a worldwide problem, accurate pathological and functional evaluation is required for planning treatment and follow-up. Intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) can assess both capillary perfusion and tissue diffusion and may be helpful in evaluating renal function and pathology. PURPOSE: To evaluate functional and pathological alterations in CKD by applying IVIM-DWI. STUDY TYPE: Prospective study...
September 21, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28929210/discrimination-of-malignant-versus-benign-mediastinal-lymph-nodes-using-diffusion-mri-with-an-ivim-model
#20
Li-Ping Qi, Wan-Pu Yan, Ke-Neng Chen, Zheng Zhong, Xiao-Ting Li, Kejia Cai, Ying-Shi Sun, Xiaohong Joe Zhou
OBJECTIVES: To investigate the value of an intravoxel incoherent motion (IVIM) diffusion model for discriminating malignant versus benign mediastinal lymph nodes (MLN). METHODS: Thirty-five subjects with enlarged MLN were scanned at 1.5 Tesla. Diffusion-weighted imaging was performed with eight b-values. IVIM parameters D, D*, and f, as well as apparent diffusion coefficient (ADC) from a mono-exponential model were obtained. 91 nodes (49 malignant and 42 benign) were analysed with pathologic (n=90) or radiologic (n=1) confirmations...
September 19, 2017: European Radiology
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