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https://www.readbyqxmd.com/read/28929210/discrimination-of-malignant-versus-benign-mediastinal-lymph-nodes-using-diffusion-mri-with-an-ivim-model
#1
Li-Ping Qi, Wan-Pu Yan, Ke-Neng Chen, Zheng Zhong, Xiao-Ting Li, Kejia Cai, Ying-Shi Sun, Xiaohong Joe Zhou
OBJECTIVES: To investigate the value of an intravoxel incoherent motion (IVIM) diffusion model for discriminating malignant versus benign mediastinal lymph nodes (MLN). METHODS: Thirty-five subjects with enlarged MLN were scanned at 1.5 Tesla. Diffusion-weighted imaging was performed with eight b-values. IVIM parameters D, D*, and f, as well as apparent diffusion coefficient (ADC) from a mono-exponential model were obtained. 91 nodes (49 malignant and 42 benign) were analysed with pathologic (n=90) or radiologic (n=1) confirmations...
September 19, 2017: European Radiology
https://www.readbyqxmd.com/read/28914609/effect-of-multiple-perfusion-components-on-pseudo-diffusion-coefficient-in-intravoxel-incoherent-motion-imaging
#2
Zi-Xiang Kuai, Wan-Yu Liu, Yue-Min Zhu
The aim of this work was to investigate the effect of multiple perfusion components on the pseudo-diffusion coefficient D* in the bi-exponential intravoxel incoherent motion (IVIM) model. Simulations were first performed to examine how the presence of multiple perfusion components influences D*. The real data of livers (n=31), spleens (n=31) and kidneys (n=31) of 31 volunteers was then acquired using DWI for in vivo study and the number of perfusion components in these tissues was determined together with their perfusion fraction and D*, using an adaptive multi-exponential IVIM model...
September 15, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28912536/predictive-and-prognostic-value-of-intravoxel-incoherent-motion-ivim-mr-imaging-in-patients-with-advanced-cervical-cancers-undergoing-concurrent-chemo-radiotherapy
#3
Li Zhu, Huanhuan Wang, Lijing Zhu, Jie Meng, Yan Xu, Baorui Liu, Weibo Chen, Jian He, Zhengyang Zhou, Xiaofeng Yang
By using the intravoxel incoherent motion (IVIM) model, the diffusion-related coefficient (D) and the perfusion-related parameter (f) can be obtained simultaneously. Here, we explored the application of IVIM MR imaging in predicting long-term prognosis in patients with advanced cervical cancers treated with concurrent chemo-radiotherapy (CCRT). In this study, pelvic MR examinations including an IVIM sequence were performed on 30 women with advanced cervical cancers at three time points (within 2 weeks before, as well as 2 and 4 weeks after, the initiation of CCRT)...
September 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28881847/to-predict-the-radiosensitivity-of-nasopharyngeal-carcinoma-using-intravoxel-incoherent-motion-mri-at-3-0-t
#4
Wen Bo Chen, Bin Zhang, Long Liang, Yu Hao Dong, Guan Hui Cai, Chang Hong Liang, Bo Wen Lan, Shui Xing Zhang
PURPOSE: To investigate intravoxel incoherent motion (IVIM) MRI for evaluating the sensitivity of radiotherapy on nasopharyngeal carcinoma (NPC). RESULTS: The reproducibility between intra-observer and inter-observer was relatively good. D (0.72×10(-3) mm(2)/s±0.14 vs. 0.54×10(-3) mm(2)/s±0.23; P < 0.001) and D* (157.92×10(-3) mm(2)/s±15.21 vs. 120.36×10(-3) mm(2)/s±10.22; P < 0.0001) were significantly higher in effective group than poor-effective group, whereas the difference of f (18...
August 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28866259/intravoxel-incoherent-motion-diffusion-weighted-imaging-evaluation-of-the-differentiation-of-solid-hepatic-lesions
#5
Ma Luo, Ling Zhang, Xin-Hua Jiang, Wei-Dong Zhang
PURPOSE: To evaluate whether intravoxel incoherent motion (IVIM)-related parameters could be used to differentiate malignant from benign focal liver lesions (FLLs) and to improve diagnostic efficiency. METHODS: Seventy-four patients with 75 lesions, including 51 malignant FLLs and 24 benign FLLs, underwent liver 3.0-T magnetic resonance imaging for routine examination sequences. IVIM diffusion-weighted imaging (DWI) with 11 b values (0-800s/mm(2)) was also acquired concurrently...
August 30, 2017: Translational Oncology
https://www.readbyqxmd.com/read/28860901/correlation-between-intravoxel-incoherent-motion-magnetic-resonance-imaging-derived-metrics-and-serum-soluble-cd40-ligand-level-in-an-embolic-canine-stroke-model
#6
Xiao-Quan Xu, Chen-Jiang Wu, Shan-Shan Lu, Qian-Qian Gao, Qing-Quan Zu, Xing-Long Liu, Hai-Bin Shi, Sheng Liu
OBJECTIVE: To determine the relationship between intravoxel incoherent motion (IVIM) imaging derived quantitative metrics and serum soluble CD40 ligand (sCD40L) level in an embolic canine stroke model. MATERIALS AND METHODS: A middle cerebral artery occlusion model was established in 24 beagle dogs. Experimental dogs were divided into low- and high-sCD40L group according to serum sCD40L level at 4.5 hours after establishing the model. IVIM imaging was scanned at 4...
September 2017: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
https://www.readbyqxmd.com/read/28856177/intravoxel-incoherent-motion-ivim-histogram-biomarkers-for-prediction-of-neoadjuvant-treatment-response-in-breast-cancer-patients
#7
Gene Y Cho, Lucas Gennaro, Elizabeth J Sutton, Emily C Zabor, Zhigang Zhang, Dilip Giri, Linda Moy, Daniel K Sodickson, Elizabeth A Morris, Eric E Sigmund, Sunitha B Thakur
OBJECTIVE: To examine the prognostic capabilities of intravoxel incoherent motion (IVIM) metrics and their ability to predict response to neoadjuvant treatment (NAT). Additionally, to observe changes in IVIM metrics between pre- and post-treatment MRI. METHODS: This IRB-approved, HIPAA-compliant retrospective study observed 31 breast cancer patients (32 lesions). Patients underwent standard bilateral breast MRI along with diffusion-weighted imaging before and after NAT...
2017: European Journal of Radiology Open
https://www.readbyqxmd.com/read/28828723/the-value-of-advanced-mri-techniques-in-the-assessment-of-cervical-cancer-a-review
#8
REVIEW
Evelyn Dappa, Tania Elger, Annette Hasenburg, Christoph Düber, Marco J Battista, Andreas M Hötker
OBJECTIVES: To assess the value of new magnetic resonance imaging (MRI) techniques in cervical cancer. METHODS: We searched PubMed and MEDLINE and reviewed articles published from 1990 to 2016 to identify studies that used MRI techniques, such as diffusion weighted imaging (DWI), intravoxel incoherent motion (IVIM) and dynamic contrast enhancement (DCE) MRI, to assess parametric invasion, to detect lymph node metastases, tumour subtype and grading, and to detect and predict tumour recurrence...
August 21, 2017: Insights Into Imaging
https://www.readbyqxmd.com/read/28828711/does-intravoxel-incoherent-motion-reliably-stage-hepatic-fibrosis-steatosis-and-inflammation
#9
Kumaresan Sandrasegaran, Paul Territo, Reem M Elkady, Yuning Lin, Pauley Gasparis, Gitasree Borthakur, Chen Lin
OBJECTIVE: To investigate the usefulness of intravoxel incoherent motion (IVIM) in determining the severity of hepatic fibrosis, steatosis, and inflammation in patients with chronic liver disease. METHODS: Forty-nine patients who had liver MRI with IVIM sequence and liver biopsy within three months of MRI were enrolled. A reviewer, blinded to histology, placed regions of interest of 1-2 cm(2) in the right liver lobe. In addition, the first twenty patients were assessed with a second reviewer...
August 21, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28819296/intravoxel-incoherent-motion-diffusion-weighted-imaging-for-discriminating-the-pathological-response-to-neoadjuvant-chemoradiotherapy-in-locally-advanced-rectal-cancer
#10
Wen Lu, Hou Jing, Zhou Ju-Mei, Nie Shao-Lin, Cao Fang, Yu Xiao-Ping, Lu Qiang, Zeng Biao, Zhu Su-Yu, Hu Ying
To investigate the usefulness of intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) in discriminating the pathological complete response (pCR) to neoadjuvant chemoradiotherapy (nCRT) in locally advanced rectal cancer (LARC), 42 patients underwent preoperative IVIM-DWI before (pre-nCRT) and after nCRT (post-nCRT). The values of pre-nCRT and post-nCRT IVIM-DWI parameters (ADC, D, D* and f), together with the percentage changes (∆% parametric value) induced by nCRT, were compared between the pCR (tumour regression grade [TRG] 4) and non-pCR (TRG 0, 1, 2 or 3) groups and between the GR (TRG 3 or 4) and PR (TRG 0, 1 or 2) groups based on the Dworak TRG system...
August 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28819085/histological-grading-of-hepatocellular-carcinomas-with-intravoxel-incoherent-motion-diffusion-weighted-imaging-inconsistent-results-depending-on-the-fitting-method
#11
Shintaro Ichikawa, Utaroh Motosugi, Diego Hernando, Hiroyuki Morisaka, Nobuyuki Enomoto, Masanori Matsuda, Hiroshi Onishi
PURPOSE: To compare the abilities of three intravoxel incoherent motion (IVIM) imaging approximation methods to discriminate the histological grade of hepatocellular carcinomas (HCCs). METHODS: Fifty-eight patients (60 HCCs) underwent IVIM imaging with 11 b-values (0-1000 s/mm(2)). Slow (D) and fast diffusion coefficients (D(*)) and the perfusion fraction (f) were calculated for the HCCs using the mean signal intensities in regions of interest drawn by two radiologists...
August 16, 2017: Magnetic Resonance in Medical Sciences: MRMS
https://www.readbyqxmd.com/read/28817196/technical-note-quantitative-analysis-of-ivim-diffusion-mri-using-total-variation-and-huber-penalty-function
#12
Esha Baidya Kayal, Devasenathipathy Kandasamy, Kedar Khare, Jayendra Tiru Alampally, Sameer Bakhshi, Raju Sharma, Amit Mehndiratta
PURPOSE: Quantitative analysis in Intra-voxel Incoherent Motion (IVIM) imaging commonly uses voxel-wise estimation of the bi-exponential model, which might not be reliable for clinical interpretation. Improving model fitting performance and qualitative and quantitative parametric estimation, two novel methodologies are proposed here. METHODS: Five IVIM analyses methodologies: i) Bi-Exponential (BE) model, ii) Segmented BE method with 2-parameter fitting (BEseg-2), iii) Segmented BE method with 1-parameter fitting (BEseg-1), iv) BE with adaptive Total Variation Penalty function (BE+TV) and v) BE with adaptive Huber Penalty function (BE+HPF) were evaluated...
August 17, 2017: Medical Physics
https://www.readbyqxmd.com/read/28815808/intravoxel-incoherent-motion-diffusion-weighted-imaging-in-assessing-bladder-cancer-invasiveness-and-cell-proliferation
#13
Fang Wang, Lian-Ming Wu, Xiao-Lan Hua, Zi-Zhou Zhao, Xiao-Xi Chen, Jian-Rong Xu
BACKGROUND: Nonmuscle-invasive bladder cancer (NMIBC, Stage T1 or lower) is treated with transurethral resection (TUR), while muscle-invasive bladder cancer (MIBC, Stage T2 or more) requires neoadjuvant chemotherapy before radical cystectomy. Hence, preoperative differentiation is vital. PURPOSE: To investigate whether intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI) can differentiate NMIBC from MIBC and to assess whether there were correlations between IVIM parameters and the Ki-67 labeling index (LI)...
August 17, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28750363/to-predict-the-radiosensitivity-of-nasopharyngeal-carcinoma-using-intravoxel-incoherent-motion-mri-at-3-0-t
#14
Wen Bo Chen, Bin Zhang, Long Liang, Yu Hao Dong, Guan Hui Cai, Chang Hong Liang, Bo Wen Lan, Shui Xing Zhang
PURPOSE: To investigate intravoxel incoherent motion (IVIM) MRI for evaluating the sensitivity of radiotherapy on nasopharyngeal carcinoma (NPC). RESULTS: The reproducibility between intra-observer and inter-observer was relatively good. D (0.72×10-3 mm2/s±0.14 vs. 0.54×10-3 mm2/s±0.23; P < 0.001) and D* (157.92×10-3 mm2/s±15.21 vs. 120.36×10-3 mm2/s±10.22; P < 0.0001) were significantly higher in effective group than poor-effective group, whereas the difference of f (18...
April 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/28741732/lung-cancer-short-term-reproducibility-of-intravoxel-incoherent-motion-parameters-and-apparent-diffusion-coefficient-at-3t
#15
Jianqin Jiang, Jianbin Yin, Lei Cui, Xiaowen Gu, Rongfang Cai, Shenchu Gong, Yiming Xu, Hang Ma, Jian Mao
PURPOSE: To prospectively evaluate the short-term reproducibility of intravoxel incoherent motion (IVIM) parameters and apparent diffusion coefficient (ADC) in lung cancer patients. MATERIALS AND METHODS: In all, 50 patients (50 lesions) underwent free-breathing diffusion-weighted imaging (DWI) (b = 0, 300, 800 s/mm(2) ) and IVIM (10 b-values, 0-1000 s/mm(2) ) scans twice (0.5-1-hour interval) at 3T. Regions of interests (ROIs) were drawn on ADC maps and IVIM images to derive the mean ADC value and IVIM parameters D, D*, and f...
July 25, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28741366/comparison-of-bi-exponential-and-mono-exponential-models-of-diffusion-weighted-imaging-for-detecting-active-sacroiliitis-in-ankylosing-spondylitis
#16
Haitao Sun, Kai Liu, Hao Liu, Zongfei Ji, Yan Yan, Lindi Jiang, Jianjun Zhou
Background There has been a growing need for a sensitive and effective imaging method for the differentiation of the activity of ankylosing spondylitis (AS). Purpose To compare the performances of intravoxel incoherent motion (IVIM)-derived parameters and the apparent diffusion coefficient (ADC) for distinguishing AS-activity. Material and Methods One hundred patients with AS were divided into active (n = 51) and non-active groups (n = 49) and 21 healthy volunteers were included as control. The ADC, diffusion coefficient ( D), pseudodiffusion coefficient ( D*), and perfusion fraction ( f) were calculated for all groups...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28714249/simultaneous-magnetic-resonance-diffusion-and-pseudo-diffusion-tensor-imaging
#17
Meghdoot Mozumder, Leandro Beltrachini, Quinten Collier, Jose M Pozo, Alejandro F Frangi
PURPOSE: An emerging topic in diffusion magnetic resonance is imaging blood microcirculation alongside water diffusion using the intravoxel incoherent motion (IVIM) model. Recently, a combined IVIM diffusion tensor imaging (IVIM-DTI) model was proposed, which accounts for both anisotropic pseudo-diffusion due to blood microcirculation and anisotropic diffusion due to tissue microstructures. In this article, we propose a robust IVIM-DTI approach for simultaneous diffusion and pseudo-diffusion tensor imaging...
July 16, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28708735/evaluation-and-minimization-of-the-pseudohepatic-anisotropy-artifact-in-liver-intravoxel-incoherent-motion
#18
Oi Lei Wong, Gladys Goh Lo, Jing Yuan, Wai Kit Chung, Wing Hung Benny Ho, Michael D Noseworthy
PURPOSE: The aim of this study was to evaluate the effect of the pseudohepatic anisotropy artifact on liver intravoxel incoherent motion (IVIM) metrics and whether the use of multiple gradient directions in the IVIM acquisition minimizes the artifact. MATERIALS AND METHODS: Multiple breath-holding and forced shallow free-breathing IVIM scans were performed on 8 healthy volunteers using 1 and 6 gradient directions. Cluster analysis was carried out to separate motion-contaminated parenchyma from liver parenchyma and vessels...
September 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28708726/measuring-cerebral-hypoperfusion-induced-by-hyperventilation-challenge-with-intravoxel-incoherent-motion-magnetic-resonance-imaging-in-healthy-volunteers
#19
Aude Pavilla, Alessandro Arrigo, Mehdi Mejdoubi, Régis Duvauferrier, Giulio Gambarota, Hervé Saint-Jalmes
OBJECTIVES: The aim of this study was to demonstrate the feasibility to assess cerebral hypoperfusion with a hyperventilation (HV) challenge protocol using intravoxel incoherent motion (IVIM) magnetic resonance imaging. MATERIALS AND METHODS: Magnetic resonance imaging experiments were performed on 10 healthy volunteers at 1.5 T, with a diffusion IVIM magnetic resonance imaging protocol using a set of b-values optimized by Cramer-Rao Lower Bound analysis. Hypoperfusion was induced by an HV maneuver...
July 13, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28703102/intravoxel-incoherent-motion-application-in-differentiation-of-hepatocellular-carcinoma-and-focal-nodular-hyperplasia
#20
Ma Luo, Ling Zhang, Xin Hua Jiang, Wei Dong Zhang
PURPOSE: We aimed to explore whether intravoxel incoherent motion (IVIM)-related parameters of hepatocellular carcinoma (HCC) and focal nodular hyperplasia (FNH) demonstrate differences that could be used to differentiate and improve diagnostic efficiency. METHODS: A total of 27 patients, including 22 with HCC and 5 with FNH, underwent liver 3.0 T magnetic resonance imaging for routine sequences. They were concurrently examined by IVIM diffusion-weighted imaging (DWI) scanning with 11 different b values (0-800 s/mm2)...
July 2017: Diagnostic and Interventional Radiology: Official Journal of the Turkish Society of Radiology
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