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https://www.readbyqxmd.com/read/27911930/the-therapeutic-response-of-gastrointestinal-stromal-tumors-to-imatinib-treatment-assessed-by-intravoxel-incoherent-motion-diffusion-weighted-magnetic-resonance-imaging-with-histopathological-correlation
#1
Feng Pan, Jie Den, Chunfang Zhang, He Wang, Jin Cheng, Weizhen Wu, Nan Hong, Yi Wang
PURPOSE: To exploit the intravoxel incoherent motion (IVIM) diffusion-weighted (DW) MRI when evaluating the therapeutic response of gastrointestinal stromal tumors (GIST) to Imatinib in a mouse model. MATERIALS AND METHODS: Mice with xenografts bearing cells from the GIST-T1 cell line were randomly divided into a treated group receiving Imatinib and a control group. DWMRI scans with 14 b-values (0-1500 s/mm2) were performed before and after treatment (days 1, 3 and 7)...
2016: PloS One
https://www.readbyqxmd.com/read/27903921/a-two-pool-model-to-describe-the-ivim-cerebral-perfusion
#2
Gabrielle Fournet, Jing-Rebecca Li, Alex M Cerjanic, Bradley P Sutton, Luisa Ciobanu, Denis Le Bihan
IntraVoxel Incoherent Motion (IVIM) is a magnetic resonance imaging (MRI) technique capable of measuring perfusion-related parameters. In this manuscript, we show that the mono-exponential model commonly used to process IVIM data might be challenged, especially at short diffusion times. Eleven rat datasets were acquired at 7T using a diffusion-weighted pulsed gradient spin echo sequence with b-values ranging from 7 to 2500 s/mm(2) at three diffusion times. The IVIM signals, obtained by removing the diffusion component from the raw MR signal, were fitted to the standard mono-exponential model, a bi-exponential model and the Kennan model...
November 30, 2016: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/27902857/quantitative-assessment-of-hyperacute-cerebral-infarction-with-intravoxel-incoherent-motion-mr-imaging-initial-experience-in-a-canine-stroke-model
#3
Qian-Qian Gao, Shan-Shan Lu, Xiao-Quan Xu, Cheng-Jiang Wu, Xing-Long Liu, Sheng Liu, Hai-Bin Shi
PURPOSE: To evaluate the feasibility of intravoxel incoherent motion (IVIM) for the measurement of diffusion and perfusion parameters in hyperacute strokes. MATERIALS AND METHODS: An embolic ischemic model was established with an autologous thrombus in 20 beagles. IVIM imaging was performed on a 3.0 Tesla platform at 4.5 h and 6 h after embolization. Ten b values from 0 to 900 s/mm(2) were fitted with a bi-exponential model to extract perfusion fraction f, diffusion coefficient D, and pseudo-diffusion coefficient D*...
November 30, 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27893459/extended-t2-ivim-model-for-correction-of-te-dependence-of-pseudo-diffusion-volume-fraction-in-clinical-diffusion-weighted-magnetic-resonance-imaging
#4
N P Jerome, J A d'Arcy, T Feiweier, D-M Koh, M O Leach, D J Collins, M R Orton
The bi-exponential intravoxel-incoherent-motion (IVIM) model for diffusion-weighted MRI (DWI) fails to account for differential T 2 s in the model compartments, resulting in overestimation of pseudodiffusion fraction f. An extended model, T2-IVIM, allows removal of the confounding echo-time (TE) dependence of f, and provides direct compartment T 2 estimates. Two consented healthy volunteer cohorts (n  =  5, 6) underwent DWI comprising multiple TE/b-value combinations (Protocol 1: TE  =  62-102 ms, b  =  0-250 mm(-2)s, 30 combinations...
December 21, 2016: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/27865032/intravoxel-incoherent-motion-diffusion-weighted-mri-of-the-abdomen-the-effect-of-fitting-algorithms-on-the-accuracy-and-reliability-of-the-parameters
#5
Hyo Jung Park, Yu Sub Sung, Seung Soo Lee, Yedaun Lee, Hyunhee Cheong, Yeong Jae Kim, Moon-Gyu Lee
PURPOSE: To evaluate the influence of fitting methods on the accuracy and reliability of intravoxel incoherent motion (IVIM) parameters, with a particular emphasis on the constraint function. MATERIALS AND METHODS: Diffusion-weighted (DW) imaging data were analyzed using IVIM-based full-fitting (simultaneous fit of all parameters) and segmented-fitting (step-by-step fit of each parameter), each with and without the constraint function, to estimate the molecular diffusion coefficient (Dslow ), perfusion fraction (f), and flow-related diffusion coefficient (Dfast )...
November 16, 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27862553/intravoxel-incoherent-motion-diffusion-weighted-mri-during-chemoradiation-therapy-to-characterize-and-monitor-treatment-response-in-human-papillomavirus-head-and-neck-squamous-cell-carcinoma
#6
Ramesh Paudyal, Jung Hun Oh, Nadeem Riaz, Praveen Venigalla, Jingao Li, Vaios Hatzoglou, Jonathan Leeman, David Aramburu Nunez, Yonggang Lu, Joseph O Deasy, Nancy Lee, Amita Shukla-Dave
PURPOSE: Characterize and monitor treatment response in human papillomavirus (HPV) head and neck squamous cell carcinoma (HNSCC) using intra-treatment (intra-TX) imaging metrics derived from intravoxel incoherent motion (IVIM) diffusion-weighted magnetic resonance imaging (DW-MRI). MATERIALS AND METHODS: Thirty-four (30 HPV positive [+] and 4 HPV negative [-]) HNSCC patients underwent a total of 136 MRI including multi-b value DW-MRI (pretreatment [pre-TX] and intra-TX weeks 1, 2, and 3) at 3...
November 11, 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27859835/differentiation-of-focal-indeterminate-marrow-abnormalities-with-multiparametric-mri
#7
Jun Seung Baik, Joon-Yong Jung, Won-Hee Jee, Chang-Woo Chun, Sun Ki Kim, Seung Han Shin, Yang Guk Chung, Chan-Kwon Jung, Stephan Kannengiesser, YoHan Sohn
PURPOSE: To explore magnetic resonance imaging (MRI) parameters from intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI), multiecho Dixon imaging (ME-Dixon), and dynamic contrast-enhanced imaging (DCE) for differentiating focal indeterminate marrow abnormalities MATERIALS AND METHODS: Forty-two patients with 14 benign and 28 malignant focal marrow abnormalities were included. The following were independently analyzed by two readers: signal intensity (SI), contour, and margin on conventional MR images; SI on b-800 images (SIb-800 ), apparent diffusion coefficient (ADC), IVIM parameters (Dslow, Dfast , and f), fat fraction (Ff), and DCE parameters (time-to-signal intensity curve pattern, iAUC, K(trans) , kep , and ve )...
November 9, 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27833401/comparison-of-biexponential-and-monoexponential-model-of-diffusion-weighted-imaging-for-distinguishing-between-common-renal-cell-carcinoma-and-fat-poor-angiomyolipoma
#8
Yuqin Ding, Mengsu Zeng, Shengxiang Rao, Caizhong Chen, Caixia Fu, Jianjun Zhou
OBJECTIVE: To compare the diagnostic accuracy of intravoxel incoherent motion (IVIM)-derived parameters and apparent diffusion coefficient (ADC) in distinguishing between renal cell carcinoma (RCC) and fat poor angiomyolipoma (AML). MATERIALS AND METHODS: Eighty-three patients with pathologically confirmed renal tumors were included in the study. All patients underwent renal 1.5T MRI, including IVIM protocol with 8 b values (0-800 s/mm(2)). The ADC, diffusion coefficient (D), pseudodiffusion coefficient (D(*)), and perfusion fraction (f) were calculated...
November 2016: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
https://www.readbyqxmd.com/read/27821130/early-evaluation-of-irradiated-parotid-glands-with-intravoxel-incoherent-motion-mr-imaging-correlation-with-dynamic-contrast-enhanced-mr-imaging
#9
Nan Zhou, Chen Chu, Xin Dou, Ming Li, Song Liu, Lijing Zhu, Baorui Liu, Tingting Guo, Weibo Chen, Jian He, Jing Yan, Zhengyang Zhou, Xiaofeng Yang, Tian Liu
BACKGROUND: Radiation-induced parotid damage is one of the most common complications in patients with nasopharyngeal carcinoma (NPC) undergoing radiotherapy (RT). Intravoxel incoherent motion (IVIM) magnetic resonance (MR) imaging has been reported for evaluating irradiated parotid damage. However, the changes of IVIM perfusion-related parameters in irradiated parotid glands have not been confirmed by conventional perfusion measurements obtained from dynamic contrast-enhanced (DCE) MR imaging...
November 8, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27818467/application-of-cardiac-gating-to-improve-the-reproducibility-of-intravoxel-incoherent-motion-measurements-in-the-head-and-neck
#10
Koung Mi Kang, Seung Hong Choi, Dong Eun Kim, Tae Jin Yun, Ji-Hoon Kim, Chul-Ho Sohn, Sun-Won Park
PURPOSE: To prospectively evaluate whether cardiac gating can improve the reproducibility of intravoxel incoherent motion (IVIM) parameters in the head and neck, we performed IVIM diffusion-weighted imaging (DWI) using 4 b values (4b), 4 b values with cardiac gating (4b gating) and 17 b values (17b). METHODS: We performed IVIM DWI twice per person on nine healthy volunteers using 4b, 4b gating and 17b and five patients with head and neck masses using 4b gating and 17b...
November 4, 2016: Magnetic Resonance in Medical Sciences: MRMS
https://www.readbyqxmd.com/read/27799790/intravoxel-incoherent-motion-model-based-analysis-of-diffusion-weighted-magnetic-resonance-imaging-with-3-b-values-for-response-assessment-in-locoregional-therapy-of-hepatocellular-carcinoma
#11
Petra Mürtz, Arndt-Hendrik Penner, Anne-Kristina Pfeiffer, Alois M Sprinkart, Claus C Pieper, Roy König, Wolfgang Block, Hans H Schild, Winfried A Willinek, Guido M Kukuk
PURPOSE: The aim of this study was to evaluate an intravoxel incoherent motion (IVIM) model-based analysis of diffusion-weighted imaging (DWI) for assessing the response of hepatocellular carcinoma (HCC) to locoregional therapy. PATIENTS AND METHODS: Respiratory-gated DWI (b=0, 50, and 800 s/mm(2)) was retrospectively analyzed in 25 patients who underwent magnetic resonance imaging at 1.5 T before and 6 weeks following the first cycle of transarterial chemoembolization therapy, transarterial ethanol-lipiodol embolization therapy, and transarterial radioembolization therapy...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27797155/total-variation-based-method-for-generation-of-intravoxel-incoherent-motion-parametric-images-in-mri
#12
Chieh Lin, Yi-Yu Shih, Siao-Lan Huang, Hsuan-Ming Huang
PURPOSE: Total variation (TV) method has been used widely for image restoration and reconstruction. In this work, we propose a TV-based algorithm for parametric image generation in intravoxel incoherent motion (IVIM) diffusion-weighted magnetic resonance imaging (DW-MRI). METHODS: We used simulated and real data to investigate whether the proposed TV-based method can provide reliable parametric images. Parametric images of IVIM parameters including perfusion fraction (PF), diffusion coefficient (D), and pseudo-diffusion coefficient (D*) were estimated using DW-MRI data and TV through fitting the IVIM model...
October 31, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/27796081/intravoxel-incoherent-motion-ivim-derived-parameters-in-diffusion-weighted-mri-associations-with-prognostic-factors-in-invasive-ductal-carcinoma
#13
Youn Joo Lee, Sung Hun Kim, Bong Joo Kang, Young Jee Kang, Heesoo Yoo, Jaewan Yoo, Jaeun Lee, Yo Han Son, Robert Grimm
PURPOSE: To investigate relationships between intravoxel incoherent motion (IVIM) metrics of invasive ductal carcinoma of the breast and prognostic factors. MATERIALS AND METHODS: This retrospective study included a total of 82 masses from 72 patients who underwent 3T breast magnetic resonance imaging (MRI) and diffusion-weighted imaging. IVIM metrics of tissue diffusivity (Dslow ), pseudodiffusivity (Dfast ), and perfusion fraction (Dpf ) were measured using histogram analysis for whole lesion volumes...
October 31, 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27787931/intravoxel-incoherent-motion-modeling-in-the-kidneys-comparison-of-mono-bi-and-triexponential-fit
#14
Sophie van Baalen, Alexander Leemans, Pieter Dik, Marc R Lilien, Bennie Ten Haken, Martijn Froeling
PURPOSE: To evaluate if a three-component model correctly describes the diffusion signal in the kidney and whether it can provide complementary anatomical or physiological information about the underlying tissue. MATERIALS AND METHODS: Ten healthy volunteers were examined at 3T, with T2 -weighted imaging, diffusion tensor imaging (DTI), and intravoxel incoherent motion (IVIM). Diffusion tensor parameters (mean diffusivity [MD] and fractional anisotropy [FA]) were obtained by iterative weighted linear least squares fitting of the DTI data and mono-, bi-, and triexponential fit parameters (D1 , D2 , D3 , ffast2 , ffast3 , and finterm ) using a nonlinear fit of the IVIM data...
October 27, 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27779790/voxelwise-analysis-of-simultaneously-acquired-and-spatially-correlated-18-f-fluorodeoxyglucose-fdg-pet-and-intravoxel-incoherent-motion-metrics-in-breast-cancer
#15
Jason Ostenson, Akshat C Pujara, Artem Mikheev, Linda Moy, Sungheon G Kim, Amy N Melsaether, Komal Jhaveri, Sylvia Adams, David Faul, Christopher Glielmi, Christian Geppert, Thorsten Feiweier, Kimberly Jackson, Gene Y Cho, Fernando E Boada, Eric E Sigmund
PURPOSE: Diffusion-weighted imaging (DWI) and (18) F-fluorodeoxyglucose-positron emission tomography ((18) F-FDG-PET) independently correlate with malignancy in breast cancer, but the relationship between their structural and metabolic metrics is not completely understood. This study spatially correlates diffusion, perfusion, and glucose avidity in breast cancer with simultaneous PET/MR imaging and compares correlations with clinical prognostics. METHODS: In this Health Insurance Portability and Accountability Act-compliant prospective study, with written informed consent and approval of the institutional review board and using simultaneously acquired FDG-PET and DWI, tissue diffusion (Dt ), and perfusion fraction (fp ) from intravoxel incoherent motion (IVIM) analysis were registered to FDG-PET within 14 locally advanced breast cancers...
October 25, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/27776645/simultaneous-multi-slice-echo-planar-diffusion-weighted-imaging-of-the-liver-and-the-pancreas-optimization-of-signal-to-noise-ratio-and-acquisition-time-and-application-to-intravoxel-incoherent-motion-analysis
#16
Andreas Boss, Borna Barth, Lukas Filli, David Kenkel, Moritz C Wurnig, Marco Piccirelli, Caecilia S Reiner
PURPOSE: To optimize and test a diffusion-weighted imaging (DWI) echo-planar imaging (EPI) sequence with simultaneous multi-slice (SMS) excitation in the liver and pancreas regarding acquisition time (TA), number of slices, signal-to-noise ratio (SNR), image quality (IQ), apparent diffusion coefficient (ADC) quantitation accuracy, and feasibility of intravoxel incoherent motion (IVIM) analysis. MATERIALS AND METHODS: Ten healthy volunteers underwent DWI of the upper abdomen at 3T...
November 2016: European Journal of Radiology
https://www.readbyqxmd.com/read/27764817/intravoxel-incoherent-motion-ivim-in-diffusion-weighted-imaging-dwi-for-hepatocellular-carcinoma-correlation-with-histologic-grade
#17
Vincenza Granata, Roberta Fusco, Orlando Catalano, Benedetta Guarino, Francesco Granata, Fabiana Tatangelo, Antonio Avallone, Mauro Piccirillo, Raffaele Palaia, Francesco Izzo, Antonella Petrillo
PURPOSE: To assess the correlation between DWI diffusion parameters obtained using Intravoxel Incoherent Motion Method (IVIM) and histological grade of Hepatocellular carcinoma (HCC). RESULTS: According to Edmondson-Steiner grade lesions were classified with grade 1 (14), grade 2 (30), grade 3 (18), and grade 4 (0). Apparent Diffusion Coefficient (ADC), perfusion fraction (fp), tissue diffusion coefficient (Dt) median values were statistically different in HCC groups with 1, 2, 3 histological grade (p<0...
October 15, 2016: Oncotarget
https://www.readbyqxmd.com/read/27747940/generalization-of-intravoxel-incoherent-motion-model-by-introducing-the-notion-of-continuous-pseudodiffusion-variable
#18
Zi-Xiang Kuai, Wan-Yu Liu, Yan-Li Zhang, Yue-Min Zhu
PURPOSE: A generalized intravoxel incoherent motion (IVIM) model, called the GIVIM, was proposed to better account for complex perfusion present in the tissues having various vessels and flow regimes, such as the liver. THEORY AND METHODS: The notions of continuous pseudodiffusion variable as well as perfusion fraction density function were introduced to describe the presence of multiple perfusion components in a voxel. The mean and standard deviation of Gaussian perfusion fraction density function were then used to define two new parameters, the mean pseudodiffusivity ( D¯) and pseudodiffusion dispersion (σ)...
November 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/27742437/intravoxel-incoherent-motion-diffusion-weighted-imaging-as-an-adjunct-to-dynamic-contrast-enhanced-mri-to-improve-accuracy-of-the-differential-diagnosis-of-benign-and-malignant-breast-lesions
#19
Dejing Ma, Feng Lu, Xuexue Zou, Hu Zhang, Yangyang Li, Lin Zhang, Liang Chen, Dongjing Qin, Bin Wang
PURPOSE: To investigate the value of use of intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) as an adjunct to dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) to distinguish benign from malignant breast lesions. MATERIALS AND METHODS: Retrospective analysis of data pertaining to 117 patients with breast lesions who underwent DCE-MRI and IVIM-DWI examination with 3.0T MRI was conducted. A total of 128 lesions were pathologically confirmed (47 benign and 81 malignant)...
October 11, 2016: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/27742432/correlation-study-between-intravoxel-incoherent-motion-mri-and-dynamic-contrast-enhanced-mri-in-head-and-neck-squamous-cell-carcinoma-evaluation-in-primary-tumors-and-metastatic-nodes
#20
Simona Marzi, Francesca Piludu, Chiara Forina, Giuseppe Sanguineti, Renato Covello, Giuseppe Spriano, Antonello Vidiri
OBJECTIVE: To correlate intravoxel incoherent motion (IVIM) imaging and dynamic contrast-enhanced (DCE) MRI in head and neck squamous cell carcinoma (HNSCC). METHODS: Forty untreated patients with HNSCC were included retrospectively in the study. Perfusion fraction f, diffusion coefficient D and perfusion-related diffusion coefficient D* were extracted by bi-exponential fitting of IVIM data. Semi-quantitative DCE-MRI parameters, including positive enhancement integral (PEI) and maximum slope of increase (MSI), were calculated...
October 11, 2016: Magnetic Resonance Imaging
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