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https://www.readbyqxmd.com/read/28640476/histogram-analyses-of-diffusion-kurtosis-indices-and-apparent-diffusion-coefficient-in-assessing-liver-regeneration-after-alpps-and-a-comparative-study-with-portal-vein-ligation
#1
Ruo-Fan Sheng, He-Qing Wang, Kai-Pu Jin, Li Yang, Hao Liu, Yuan Ji, Cai-Xia Fu, Meng-Su Zeng
PURPOSE: To investigate the value of diffusion kurtosis imaging (DKI) histogram analysis in assessing liver regeneration and the microstructure basis after associating liver partition and portal vein ligation for staged hepatectomy (ALPPS), in comparison with portal vein ligation (PVL). MATERIALS AND METHODS: Thirty rats were divided into the ALPPS, PVL, and control groups. Histograms of DKI using a 3T magnetic resonance imaging (MRI) scanner were performed for corrected apparent diffusion (D), kurtosis (K), and apparent diffusion coefficient (ADC)...
June 22, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28634047/the-study-of-the-intervertebral-disc-microstructure-in-matured-rats-with-diffusion-kurtosis-imaging
#2
Li Li, Wenzhen Zhu, Weiwei Chen, Jicheng Fang, Jing Li
OBJECTIVES: The aim of this study was to use DKI to detect the microstructural change of the discs in matured normal rats. METHODS: Total 24 normal SD rats (12 males/12 females) underwent DWI/DKI and T2 sequences with a 3T MRI scanner to get the values of ADC, FA, MD, Da, Dr, MK, Ka and Kr. The discs were categorized using a five-grade degeneration grading system in the T2-images. The height of the discs and the parameters in DWI/DKI were measured to compare between the different grades and sexes...
June 17, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28629955/correlation-study-between-dki-and-conventional-dwi-in-brain-and-head-and-neck-tumors
#3
Silvia Minosse, Simona Marzi, Francesca Piludu, Antonello Vidiri
PURPOSE: To investigate the relationship between the Diffusion Kurtosis Imaging (DKI) parameters and conventional metrics provided by Diffusion-weighted imaging (DWI) in patients affected by Brain or Head and Neck (HN) cancer. METHODS: Ten patients affected by brain tumor and nine patients with HN tumor underwent a pre-treatment MR examination at 3 T. The largest tumor section was manually contoured by two expert neuroradiologists. The apparent diffusion coefficient (Dapp) and apparent diffusional kurtosis (Kapp) parameters were determined at the voxel level by using the DKI model, and compared to the apparent diffusion coefficient (ADC) and the tissue diffusion coefficient (Dmono) obtained from mono-exponential fitting methods...
June 16, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28616727/preliminary-study-of-diffusion-kurtosis-imaging-in-thyroid-nodules-and-its-histopathologic-correlation
#4
Ruo-Yang Shi, Qiu-Ying Yao, Qin-Yi Zhou, Qing Lu, Shi-Teng Suo, Jun Chen, Wen-Jie Zheng, Yong-Ming Dai, Lian-Ming Wu, Jian-Rong Xu
OBJECTIVES: To evaluate the utility of diffusion kurtosis imaging (DKI) of patients with thyroid nodules and to assess the probable correlation with histopathological factors. METHODS: The study included 58 consecutive patients with thyroid nodules who underwent magnetic resonance imaging (MRI) examination, including DKI and diffusion-weighted imaging (DWI). Histopathological analysis of paraffin sections included cell density and immunohistochemical analysis of Ki-67 and vascular endothelial growth factor (VEGF)...
June 14, 2017: European Radiology
https://www.readbyqxmd.com/read/28608327/diffusional-kurtosis-imaging-dki-incorporation-into-an-intravoxel-incoherent-motion-ivim-mr-model-to-measure-cerebral-hypoperfusion-induced-by-hyperventilation-challenge-in-healthy-subjects
#5
Aude Pavilla, Giulio Gambarota, Alessandro Arrigo, Mehdi Mejdoubi, Régis Duvauferrier, Hervé Saint-Jalmes
OBJECTIVES: The objectives were to investigate the diffusional kurtosis imaging (DKI) incorporation into the intravoxel incoherent motion (IVIM) model for measurements of cerebral hypoperfusion in healthy subjects. MATERIALS AND METHODS: Eight healthy subjects underwent a hyperventilation challenge with a 4-min diffusion weighted imaging protocol, using 8 b values chosen with the Cramer-Rao Lower Bound optimization approach. Four regions of interest in gray matter (GM) were analyzed with the DKI-IVIM model and the bi-exponential IVIM model, for normoventilation and hyperventilation conditions...
June 12, 2017: Magma
https://www.readbyqxmd.com/read/28583625/residual-tumour-detection-in-post-treatment-granulation-tissue-by-using-advanced-diffusion-models-in-head-and-neck-squamous-cell-carcinoma-patients
#6
Noriyuki Fujima, Daisuke Yoshida, Tomohiro Sakashita, Akihiro Homma, Kohsuke Kudo, Hiroki Shirato
PURPOSE: To evaluate the detectability of the residual tumour in post-treatment granulation tissue using parameters obtained with an advanced diffusion model in patients with head and neck squamous cell carcinoma (HNSCC) treated by chemoradiation therapy. MATERIALS AND METHODS: We retrospectively evaluated 23 patients with HNSCC after the full course of chemoradiation therapy. The diffusion-weighted image (DWI) acquisition used single-shot spin-echo echo-planar imaging with 11 b-values (0-1000)...
May 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28580278/fgf21-does-not-require-adipocyte-amp-activated-protein-kinase-ampk-or-the-phosphorylation-of-acetyl-coa-carboxylase-acc-to-mediate-improvements-in-whole-body-glucose-homeostasis
#7
Emilio P Mottillo, Eric M Desjardins, Andreas M Fritzen, Vito Z Zou, Justin D Crane, Julian M Yabut, Bente Kiens, Derek M Erion, Adhiraj Lanba, James G Granneman, Saswata Talukdar, Gregory R Steinberg
OBJECTIVE: Fibroblast growth factor 21 (FGF21) shows great potential for the treatment of obesity and type 2 diabetes, as its long-acting analogue reduces body weight and improves lipid profiles of participants in clinical studies; however, the intracellular mechanisms mediating these effects are poorly understood. AMP-activated protein kinase (AMPK) is an important energy sensor of the cell and a molecular target for anti-diabetic medications. This work examined the role of AMPK in mediating the glucose and lipid-lowering effects of FGF21...
June 2017: Molecular Metabolism
https://www.readbyqxmd.com/read/28577319/diffusion-kurtosis-mri-versus-conventional-diffusion-weighted-imaging-for-evaluating-inflammatory-activity-in-crohn-s-disease
#8
Li Huang, Xue-Hua Li, Si-Yun Huang, Zhong-Wei Zhang, Xu-Feng Yang, Jin-Jiang Lin, Meng-Jie Jiang, Shi-Ting Feng, Can-Hui Sun, Zi-Ping Li
PURPOSE: To assess the efficacy of diffusion kurtosis imaging (DKI) and to compare DKI-derived parameters with that of conventional diffusion-weighted imaging (DWI) for grading the inflammatory activity of Crohn's disease (CD). MATERIALS AND METHODS: In all, 38 patients with CD underwent 3T magnetic resonance enterography (MRE) with DKI (b values of 0-2000 s/mm(2) ). The inflammatory activity of the bowel segments was graded by magnetic resonance index of activity (MaRIA) as inactive (<7), mild (≥7 and <11), or moderate-severe (≥11)...
June 3, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28560158/application-and-evaluation-of-noddi-in-the-cervical-spinal-cord-of-multiple-sclerosis-patients
#9
Samantha By, Junzhong Xu, Bailey A Box, Francesca R Bagnato, Seth A Smith
INTRODUCTION: There is a need to develop imaging methods sensitive to axonal injury in multiple sclerosis (MS), given the prominent impact of axonal pathology on disability and outcome. Advanced multi-compartmental diffusion models offer novel indices sensitive to white matter microstructure. One such model, neurite orientation dispersion and density imaging (NODDI), is sensitive to neurite morphology, providing indices of apparent volume fractions of axons (vin), isotropic water (viso) and the dispersion of fibers about a central axis (orientation dispersion index, ODI)...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28543843/white-matter-biomarkers-from-fast-protocols-using-axially-symmetric-diffusion-kurtosis-imaging
#10
Brian Hansen, Ahmad R Khan, Noam Shemesh, Torben E Lund, Ryan Sangill, Simon F Eskildsen, Leif Østergaard, Sune N Jespersen
White matter tract integrity (WMTI) can characterize brain microstructure in areas with highly aligned fiber bundles. Several WMTI biomarkers have now been validated against microscopy and provided promising results in studies of brain development and aging, as well as in a number of brain disorders. Currently, WMTI is mostly used in dedicated animal studies and clinical studies of slowly progressing diseases, and has not yet emerged as a routine clinical tool. To this end, a less data intensive experimental method would be beneficial by enabling high resolution validation studies, and ease clinical applications by speeding up data acquisition compared with typical diffusion kurtosis imaging (DKI) protocols utilized as part of WMTI imaging...
May 22, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/28515412/utility-of-a-hybrid-ivim-dki-model-to-predict-the-development-of-distant-metastasis-in-head-and-neck-squamous-cell-carcinoma-patients
#11
Noriyuki Fujima, Tomohiro Sakashita, Akihiro Homma, Daisuke Yoshida, Kohsuke Kudo, Hiroki Shirato
PURPOSE: To evaluate the diagnostic power of hybrid intravoxel incoherent motion (IVIM)-diffusion kurtosis imaging (DKI) model parameters in pretreatment for the prediction of future distant metastasis in head and neck squamous cell carcinoma (HNSCC) patients. MATERIALS AND METHODS: We retrospectively evaluated 49 HNSCC patients who underwent curative chemoradiation therapy. Diffusion-weighted image (DWI) acquired by single-shot spin-echo echo-planar imaging with 12 b-values (0-2000) was performed in all patients before any treatment...
May 18, 2017: Magnetic Resonance in Medical Sciences: MRMS
https://www.readbyqxmd.com/read/28514763/the-value-of-diffusion-kurtosis-imaging-in-assessing-pathological-complete-response-to-neoadjuvant-chemoradiation-therapy-in-rectal-cancer-a-comparison-with-conventional-diffusion-weighted-imaging
#12
Feixiang Hu, Wei Tang, Yiqun Sun, Dang Wan, Sanjun Cai, Zhen Zhang, Robert Grimm, Xu Yan, Caixia Fu, Tong Tong, Weijun Peng
OBJECTIVES: The aim of this study is to comprehensively evaluate the advantage of diffusion kurtosis imaging (DKI) in distinguishing pathological complete response (pCR) from non-pCR patients with locally advanced rectal cancer (LARC) after neoadjuvant chemoradiation therapy (CRT) in comparison to conventional diffusion-weighted imaging (DWI). MATERIAL AND METHODS: Fifty-six consecutive patients diagnosed with LARC were prospectively enrolled and underwent pre- and post-CRT MRI on a 3...
April 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28509567/early-evaluation-of-radiation-induced-parotid-damage-with-diffusion-kurtosis-imaging-a-preliminary-study
#13
Nan Zhou, Weibo Chen, Xia Pan, Jian He, Jing Yan, Zhengyang Zhou, Xiaofeng Yang
Background Radiation-induced parotid gland damage is a common complication of radiotherapy (RT) in patients with nasopharyngeal carcinoma (NPC), which always causes xerostomia, dysphagia, dental caries, and even sleep disorders. Early evaluation of radiation-induced parotid damage is required to facilitate early interventions. Purpose To early-evaluate radiation-induced parotid damage using diffusion kurtosis imaging (DKI) in patients with NPC undergoing RT. Material and Methods Thirty-two patients with NPC underwent DKI for parotid glands pre-RT (two weeks before RT), mid-RT (five weeks after RT began), and post-RT (four weeks after RT)...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28484279/diffusion-kurtosis-imaging-of-microstructural-alterations-in-the-brains-of-paediatric-patients-with-congenital-sensorineural-hearing-loss
#14
Wenbin Zheng, Chunxiao Wu, Lexing Huang, Renhua Wu
Our aim was to assess microstructural alterations in the cerebrums of paediatric patients with congenital sensorineural hearing loss (SNHL) using diffusion kurtosis imaging (DKI). Seventy-two paediatric SNHL patients and 38 age-matched healthy volunteers were examined via DKI using a 3.0 T magnetic resonance (MR) imager. Fractional anisotropy (FA) and mean kurtosis (MK) values were computed for 12 cerebral regions in both the controls and the SNHL patients. Compared with patients below age 3, patients in the older age group were found to have more significant differences in MK than in FA, and these appeared in more major areas of the brain...
May 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28470878/gray-matter-abnormalities-in-idiopathic-parkinson-s-disease-evaluation-by-diffusional-kurtosis-imaging-and-neurite-orientation-dispersion-and-density-imaging
#15
Koji Kamagata, Andrew Zalesky, Taku Hatano, Ryo Ueda, Maria Angelique Di Biase, Ayami Okuzumi, Keigo Shimoji, Masaaki Hori, Karen Caeyenberghs, Christos Pantelis, Nobutaka Hattori, Shigeki Aoki
Mapping gray matter (GM) pathology in Parkinson's disease (PD) with conventional MRI is challenging, and the need for more sensitive brain imaging techniques is essential to facilitate early diagnosis and assessment of disease severity. GM microstructure was assessed with GM-based spatial statistics applied to diffusion kurtosis imaging (DKI) and neurite orientation dispersion imaging (NODDI) in 30 participants with PD and 28 age- and gender-matched controls. These were compared with currently used assessment methods such as diffusion tensor imaging (DTI), voxel-based morphometry (VBM), and surface-based cortical thickness analysis...
May 4, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28454487/diffusion-kurtosis-imaging-of-the-liver-at-3-tesla-in%C3%A2-vivo-comparison-to-standard-diffusion-weighted-imaging
#16
Johannes Budjan, Elke A Sauter, Frank G Zoellner, Andreas Lemke, Jens Wambsganss, Stefan O Schoenberg, Ulrike I Attenberger
Background Functional techniques like diffusion-weighted imaging (DWI) are gaining more and more importance in liver magnetic resonance imaging (MRI). Diffusion kurtosis imaging (DKI) is an advanced technique that might help to overcome current limitations of DWI. Purpose To evaluate DKI for the differentiation of hepatic lesions in comparison to conventional DWI at 3 Tesla. Material and Methods Fifty-six consecutive patients were examined using a routine abdominal MR protocol at 3 Tesla which included DWI with b-values of 50, 400, 800, and 1000 s/mm(2)...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28448817/automated-detection-of-pathologic-white-matter-alterations-in-alzheimer-s-disease-using-combined-diffusivity-and-kurtosis-method
#17
Yuanyuan Chen, Miao Sha, Xin Zhao, Jianguo Ma, Hongyan Ni, Wei Gao, Dong Ming
Diffusion tensor imaging (DTI) and diffusion kurtosis imaging (DKI) are important diffusion MRI techniques for detecting microstructure abnormities in diseases such as Alzheimer's. The advantages of DKI over DTI have been reported generally; however, the indistinct relationship between diffusivity and kurtosis has not been clearly revealed in clinical settings. In this study, we hypothesize that the combination of diffusivity and kurtosis in DKI improves the capacity of DKI to detect Alzheimer's disease compared with diffusivity or kurtosis alone...
April 12, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28448418/effects-of-b-value-on-quantification-of-rapid-diffusion-kurtosis-imaging-in-normal-and-acute-ischemic-brain-tissues
#18
Ming-Chung Chou, Cheng-Wen Ko, Yu-Hsien Chiu, Hsiao-Wen Chung, Ping-Hong Lai
PURPOSE: Diffusion kurtosis imaging (DKI) has been widely used to characterize brain tissue alterations. Diffusion-weighting factor or b value plays an important role in the measurement of rapid DKI and may have influential effects on them. The purpose of this study was to investigate the effects of b value on rapid DKI indices in normal and acute ischemic brain tissues. MATERIALS AND METHODS: This study enrolled 10 healthy subjects and 4 acute ischemic stroke patients...
April 26, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28447147/diffusion-kurtosis-as-an-in-vivo-imaging-marker-of-early-radiation-induced-changes-in-radiation-induced-temporal-lobe-necrosis-in-nasopharyngeal-carcinoma-patients
#19
Lu Liyan, Wang Si, Wang Qian, Shao Yuhui, Wei Xiaoer, Li Yuehua, Li Wenbin
PURPOSE: Diffusion kurtosis imaging (DKI), an extension of the popular diffusion tensor imaging (DTI) model, has been applied in clinical studies of brain tissue changes. We explored the value of DKI for the early detection of radiation-induced changes in temporal lobe necrosis (TLN) after radiotherapy (RT) for nasopharyngeal carcinoma (NPC). METHODS: A total of 400 patients with NPC were retrospectively enrolled; all participants underwent MRI scans 0-7 days before RT, at 4 weeks during RT, and 1 month after completing RT...
April 26, 2017: Clinical Neuroradiology
https://www.readbyqxmd.com/read/28438531/altered-gray-and-white-matter-microstructure-in-cushing-s-disease-a-diffusional-kurtosis-imaging-study
#20
Hong Jiang, Na-Ying He, Yu-Hao Sun, Fang-Fang Jian, Liu-Guan Bian, Jian-Kang Shen, Fu-Hua Yan, Si-Jian Pan, Qing-Fang Sun
Exposure to chronic hypercortisolism has multiple adverse effects on brain biology in humans. Cushing's disease (CD) represents a unique and natural human model for examining the effects of hypercortisolism on the brain. This cross-sectional study used Diffusional Kurtosis Imaging (DKI) to investigate the microstructure alterations in both white matter (WM) and gray matter (GM) of CD patients and to determine the relationship of these changes with clinical characteristics. DKI images were obtained from 15 active CD patients...
April 21, 2017: Brain Research
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