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https://www.readbyqxmd.com/read/29029498/diffusion-kurtosis-imaging-predicts-early-radiotherapy-response-in-nasopharyngeal-carcinoma-patients
#1
Gang Wu, Meng-Meng Li, Feng Chen, Shao-Ming Lin, Kai Yang, Ying-Man Zhao, Xiao-Lei Zhu, Wei-Yuan Huang, Jian-Jun Li
In this prospective study, we analyzed diffusion kurtosis imaging (DKI) parameters to predict the early response to radiotherapy in 23 nasopharyngeal carcinoma (NPC) patients. All patients underwent conventional magnetic resonance imaging (MRI) and DKI before and after radiotherapy. The patients were divided into response (RG; no residual tumors; 16/23 patients) and no-response (NRG; residual tumors; 7/23 patients) groups, based on MRI and biopsy results 3 months after radiotherapy. The maximum diameter of tumors in RG and NRG patients were similar prior to radiotherapy (p=0...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/28987682/mr-diffusion-kurtosis-imaging-predicts-malignant-potential-and-the-histological-type-of-meningioma
#2
Fen Xing, Ning Tu, Tong San Koh, Guangyao Wu
PURPOSE: To explore the value of Diffusion kurtosis imaging (DKI) metrics in the differential diagnosis of meningioma. METHODS: For this study, we retrospectively enrolled 35 patients of cerebral meningioma with DKI which included axial diffusion coefficient (AD), radial diffusion coefficient (RD), mean diffusion coefficient (MD), fractional anisotropy (FA), axial kurtosis (AK), radial kurtosis (RK) and mean kurtosis (MK). All of these metrics were normalized according to contralateral normal-appearing white matter (NAWMc)...
October 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28987669/histogram-analysis-of-diffusion-kurtosis-imaging-estimates-for-in-vivo-assessment-of-2016-who-glioma-grades-a-cross-sectional-observational-study
#3
Johann-Martin Hempel, Jens Schittenhelm, Cornelia Brendle, Benjamin Bender, Georg Bier, Marco Skardelly, Ghazaleh Tabatabai, Salvador Castaneda Vega, Ulrike Ernemann, Uwe Klose
PURPOSE: To assess the diagnostic performance of histogram analysis of diffusion kurtosis imaging (DKI) maps for in vivo assessment of the 2016 World Health Organization Classification of Tumors of the Central Nervous System (2016 CNS WHO) integrated glioma grades. MATERIALS AND METHODS: Seventy-seven patients with histopathologically-confirmed glioma who provided written informed consent were retrospectively assessed between 01/2014 and 03/2017 from a prospective trial approved by the local institutional review board...
October 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28911770/primary-deuterium-kinetic-isotope-effects-from-product-yields-rationale-implementation-and-interpretation
#4
Tina L Amyes, John P Richard
A simple and convenient method is described to determine primary deuterium kinetic isotope effects (1°DKIEs) on reactions where the hydron incorporated into the reaction product is derived from solvent water. The 1°DKIE may be obtained by (1)H NMR analyses as the ratio of the yields of H- and D-labeled products from a reaction in 50:50 (v/v) HOH/DOD. The procedures for these (1)H NMR analyses are reviewed. This product deuterium isotope effect (PDIE) is defined as 1/ϕEL for fractionation of hydrons between solvent and the transition state for the reaction examined...
2017: Methods in Enzymology
https://www.readbyqxmd.com/read/28900220/diffusion-kurtosis-imaging-evaluating-epithelial-mesenchymal-transition-in-colorectal-carcinoma-xenografts-model-a-preliminary-study
#5
Huanhuan Liu, Wenbin Shen, Caiyuan Zhang, Yanfen Cui, Jinning Li, Tingting Zhang, Weibo Chen, Dengbin Wang
Epithelial-mesenchymal transition (EMT) plays an important role in aggravating invasiveness and metastatic behavior of colorectal cancer (CRC). Identification of EMT is important for structuring treatment strategy, but has not yet been studied by using noninvasive imaging modality. Diffusion kurtosis imaging (DKI) is an advanced diffusion weighted model that could reflect tissue microstructural changes in vivo. In this study, EMT was induced in CRC cells (HCT116) by overexpressing Snail1 gene. We aimed to investigate the value of DKI in identifying EMT in CRC and decipher the correlations between DKI-derived parameters and EMT biomarker E-cadherin and cell proliferative index Ki-67 expression...
September 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28894296/test-retest-reliability-of-high-spatial-resolution-diffusion-tensor-and-diffusion-kurtosis-imaging
#6
Pashtun Shahim, Laurena Holleran, Joong H Kim, David L Brody
We assessed the test-retest reliability of high spatial resolution diffusion tensor imaging (DTI) and diffusion kurtosis imaging (DKI). Diffusion MRI was acquired using a Siemens 3 Tesla Prisma scanner with 80 mT/m gradients and a 32-channel head coil from each of 3 concussive traumatic brain injury (cTBI) patients and 4 controls twice 0 to 24 days apart. Coefficients of variation (CoV) for DTI parameters were calculated in each DTI Studio parcellated white matter tract at 1.25 mm and 1.75 mm isotropic voxel resolution, as well as DKI parameters at 1...
September 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28865921/in-vivo-assessment-of-tumor-heterogeneity-in-who-2016-glioma-grades-using-diffusion-kurtosis-imaging-diagnostic-performance-and-improvement-of-feasibility-in-routine-clinical-practice
#7
J-M Hempel, J Schittenhelm, S Bisdas, C Brendle, B Bender, G Bier, M Skardelly, G Tabatabai, S Castaneda Vega, U Ernemann, U Klose
PURPOSE: To assess the diagnostic performance of normalized and non-normalized diffusion kurtosis imaging (DKI) metrics extracted from different tumor volume data for grading glioma according to the integrated approach of the revised 2016 WHO classification. MATERIALS AND METHODS: Sixty patients with histopathologically confirmed glioma, who provided written informed consent, were retrospectively assessed between 01/2013 and 08/2016 from a prospective trial approved by the local institutional review board...
September 1, 2017: Journal of Neuroradiology. Journal de Neuroradiologie
https://www.readbyqxmd.com/read/28845175/microstructural-abnormalities-of-basal-ganglia-and-thalamus-in-bipolar-and-unipolar-disorders-a-diffusion-kurtosis-and-perfusion-imaging-study
#8
Lianping Zhao, Ying Wang, Yanbin Jia, Shuming Zhong, Yao Sun, Zhifeng Zhou, Zhongping Zhang, Li Huang
OBJECTIVE: Bipolar disorder (BD) is often misdiagnosed as unipolar depression (UD), leading to mistreatment and poor clinical outcomes. However, little is known about the similarities and differences in subcorticalgray matter regions between BD and UD. METHODS: Thirty-five BD patients, 30 UD patients and 40 healthy controls underwent diffusional kurtosis imaging (DKI) and three dimensional arterial spin labeling (3D ASL). The parameters including mean kurtosis (MK), axial kurtosis (Ka), radial kurtosis (Kr), fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (Da), radial diffusivity (Dr) and cerebral blood flow (CBF) were measured by using regions-of-interest analysis in the caudate, putamen and thalamus of the subcortical gray matter regions...
July 2017: Psychiatry Investigation
https://www.readbyqxmd.com/read/28841758/precision-and-accuracy-of-diffusion-kurtosis-estimation-and-the-influence-of-b-value-selection
#9
Andrey Chuhutin, Brian Hansen, Sune Nørhøj Jespersen
Diffusion kurtosis imaging (DKI) is an extension of diffusion tensor imaging that accounts for leading non-Gaussian diffusion effects. In DKI studies, a wide range of different gradient strengths (b-values) is used, which is known to affect the estimated diffusivity and kurtosis parameters. Hence there is a need to assess the accuracy and precision of the estimated parameters as a function of b-value. This work examines the error in the estimation of mean of the kurtosis tensor (MKT) with respect to the ground truth, using simulations based on a biophysical model for both gray (GM) and white (WM) matter...
August 25, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/28834443/diffusion-kurtosis-imaging-helps-to-predict-upgrading-in-biopsy-proven-prostate-cancer-with-a-gleason-score-of-6
#10
Chen-Jiang Wu, Yu-Dong Zhang, Mei-Ling Bao, Hai Li, Xiao-Ning Wang, Xi-Sheng Liu, Hai-Bin Shi
OBJECTIVE: The purpose of this study was to investigate whether diffusion kurtosis imaging (DKI) is useful for predicting upgrades in Gleason score (GS) in biopsy-proven prostate cancer with a GS of 6. MATERIALS AND METHODS: A total of 46 patients with biopsy-proven GS 6 prostate cancer, 3-T DWI results, and surgical pathologic results were retrospectively included in the study. DWI data were postprocessed with monoexponential and DK models to quantify the apparent diffusion coefficient (ADC), apparent diffusion for gaussian distribution (Dapp), and apparent kurtosis coefficient (Kapp)...
August 23, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28820864/diffusion-kurtosis-imaging-and-pathology-in-spinal-cord-ischemia-reperfusion-injury-in-rabbits-a-case-control-study
#11
Daowei Li, Xiaoming Wang
BACKGROUND The aim of this study was to evaluate the application of diffusion kurtosis imaging (DKI) in spinal cord ischemia/reperfusion (SCI/R) injury and to explore its association with pathology. MATERIAL AND METHODS Japanese male long-eared rabbits were chosen and divided into 7 groups (8 rabbits in each group): control group (C group), sham-operation control group (S group), and 5 experimental groups (E-2 h group, E-24 h group, E-48 h group, E-7 d group, and E-14 d group). Tarlov scoring and immunohistochemical staining were used to assess hindlimb motor function and observe the expression of glial fiber acidic protein (GFAP), respectively...
August 18, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28818694/diffusion-time-dependence-of-microstructural-parameters-in-fixed-spinal-cord
#12
Sune Nørhøj Jespersen, Jonas Lynge Olesen, Brian Hansen, Noam Shemesh
Biophysical modelling of diffusion MRI is necessary to provide specific microstructural tissue properties. However, estimating model parameters from data with limited diffusion gradient strength, such as clinical scanners, has proven unreliable due to a shallow optimization landscape. On the other hand, estimation of diffusion kurtosis (DKI) parameters is more robust, and its parameters may be connected to microstructural parameters, given an appropriate biophysical model. However, it was previously shown that this procedure still does not provide sufficient information to uniquely determine all model parameters...
August 14, 2017: NeuroImage
https://www.readbyqxmd.com/read/28813200/brain-microstructural-abnormalities-in-patients-with-cirrhosis-without-overt-hepatic-encephalopathy-a-voxel-based-diffusion-kurtosis-imaging-study
#13
Hua-Jun Chen, Peng-Fei Liu, Qiu-Feng Chen, Hai-Bin Shi
OBJECTIVE: This study aimed to investigate whole-brain microstructural abnormalities and their correlation with cognitive impairment in patients with cirrhosis using diffusion kurtosis imaging (DKI). SUBJECTS AND METHODS: Eighteen patients with cirrhosis and 17 healthy control subjects underwent DKI. Cognition was measured using psychometric hepatic encephalopathy (HE) scores. Whole-brain voxel-based analyses were performed to investigate between-group differences in DKI-derived parameters, including mean kurtosis, axial kurtosis, and radial kurtosis...
August 16, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28774471/quantitative-evaluation-of-diffusion-kurtosis-imaging-for-grading-endometrial-carcinoma-a-comparative-study-with-diffusion-weighted-imaging
#14
COMPARATIVE STUDY
T Chen, Y Li, S-S Lu, Y-D Zhang, X-N Wang, C-Y Luo, H-B Shi
AIM: To evaluate the diagnostic performance of histogram analysis of diffusion kurtosis magnetic resonance imaging (DKI) and standard diffusion-weighted imaging (DWI) in discriminating tumour grades of endometrial carcinoma (EC). MATERIALS AND METHODS: Seventy-three patients with EC were included in this study. The apparent diffusion coefficient (ADC) value from standard DWI, apparent diffusion for Gaussian distribution (Dapp), and apparent kurtosis coefficient (Kapp) from DKI were acquired using a 3 T magnetic resonance imaging (MRI) system...
November 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28772347/diffusion-kurtosis-imaging-in-identifying-the-malignancy-of-lymph-node-during-the-primary-staging-of-rectal-cancer
#15
Jing Yu, Xin Dai, Hai-Hua Zou, Jia-Cheng Song, Yan Li, Hai-Bin Shi, Qing Xu, Hongbing Shen
AIM: To assess the diagnostic value of diffusion kurtosis imaging (DKI) for discriminating between benign and malignant lymph nodes (LNs) in patients with rectal carcinoma. METHOD: Eighty-five patients with rectal adenocarcinoma who underwent total mesorectal excision of the rectum were studied. A total of 273 lymph nodes were harvested and subjected to histological analysis.. Quantitative parameters (apparent diffusion parameter of Gaussian distribution (Dapp ), apparent kurtosis coefficient (Kapp ) and apparent diffusion coefficient (ADC)) of lymph node were derived from DKI...
August 3, 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/28752790/ph-imaging-reveals-worsened-tissue-acidification-in-diffusion-kurtosis-lesion-than-the-kurtosis-diffusion-lesion-mismatch-in-an-animal-model-of-acute-stroke
#16
Enfeng Wang, Yin Wu, Jerry S Cheung, Iris Yuwen Zhou, Takahiro Igarashi, XiaoAn Zhang, Phillip Zhe Sun
Diffusion weighted imaging (DWI) has been commonly used in acute stroke examination, yet a portion of DWI lesion may be salvageable. Recently, it has been shown that diffusion kurtosis imaging (DKI) defines the most severely damaged DWI lesion that does not renormalize following early reperfusion. We postulated that the diffusion and kurtosis lesion mismatch experience heterogeneous hemodynamic and/or metabolic injury. We investigated tissue perfusion, pH, diffusion, kurtosis and relaxation from regions of the contralateral normal area, diffusion lesion, kurtosis lesion and their mismatch in an animal model of acute stroke...
October 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28748504/whole-brain-analyses-of-age-related-microstructural-changes-quantified-using-different-diffusional-magnetic-resonance-imaging-methods
#17
Miho Ota, Noriko Sato, Norihide Maikusa, Daichi Sone, Hiroshi Matsuda, Hiroshi Kunugi
PURPOSE: The new diffusional magnetic resonance imaging (dMRI) techniques, diffusional kurtosis imaging (DKI) and neurite orientation dispersion and density imaging (NODDI) have been developed to clarify the microstructural changes. To our knowledge, however, there is little information on the similarities and differences of these metrics evaluated by the image-by-image paired t test. MATERIALS AND METHODS: Twenty-three healthy subjects underwent dMRI. We estimated the relationships of these metrics evaluated by the image-by-image paired t-test and compared aging effects on each metric...
July 26, 2017: Japanese Journal of Radiology
https://www.readbyqxmd.com/read/28740446/diffusion-kurtosis-imaging-of-gliomas-grades-ii-and-iii-a-study-of-perilesional-tumor-infiltration-tumor-grades-and-subtypes-at-clinical-presentation
#18
Anna F Delgado, Markus Fahlström, Markus Nilsson, Shala G Berntsson, Maria Zetterling, Sylwia Libard, Irina Alafuzoff, Danielle van Westen, Jimmy Lätt, Anja Smits, Elna-Marie Larsson
BACKGROUND: Diffusion kurtosis imaging (DKI) allows for assessment of diffusion influenced by microcellular structures. We analyzed DKI in suspected low-grade gliomas prior to histopathological diagnosis. The aim was to investigate if diffusion parameters in the perilesional normal-appearing white matter (NAWM) differed from contralesional white matter, and to investigate differences between glioma malignancy grades II and III and glioma subtypes (astrocytomas and oligodendrogliomas)...
June 2017: Radiology and Oncology
https://www.readbyqxmd.com/read/28725591/diffusion-weighted-imaging-of-the-prostate-principles-application-and-advances
#19
REVIEW
Martin H Maurer, Johannes T Heverhagen
This review article aims to provide an overview on the principles of diffusion-weighted magnetic resonance imaging (DW-MRI) and its applications in the imaging of the prostate. DW-MRI with regards to different applications for prostate cancer (PCa) detection and characterization, local staging as well as for active surveillance (AS) and tumor recurrence after radical prostatectomy (RP) will be discussed. Furthermore, advances in DW-MRI techniques like diffusion kurtosis imaging (DKI) will be presented.
June 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28712716/differentiation-of-glioma-malignancy-grade-using-diffusion-mri
#20
Ivan I Maximov, Aram S Tonoyan, Igor N Pronin
Modern diffusion MR protocols allow one to acquire the multi-shell diffusion data with high diffusion weightings in a clinically feasible time. In the present work we assessed three diffusion approaches based on diffusion and kurtosis tensor imaging (DTI, DKI), and neurite orientation dispersion and density imaging (NODDI) as possible biomarkers for human brain glioma grade differentiation based on the one diffusion protocol. We used three diffusion weightings (so called b-values) equal to 0, 1000, and 2500s/mm(2) with 60 non-coplanar diffusion directions in the case of non-zero b-values...
July 13, 2017: Physica Medica: PM
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