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https://www.readbyqxmd.com/read/27866239/diffusion-kurtosis-imaging-and-diffusion-weighted-imaging-in-assessment-of-liver-fibrosis-stage-and-necroinflammatory-activity
#1
Ruo Fan Sheng, He Qing Wang, Li Yang, Kai Pu Jin, Yan Hong Xie, Cai Zhong Chen, Meng Su Zeng
PURPOSE: To investigate and compare the diagnostic value of diffusion kurtosis imaging (DKI) with diffusion-weighted imaging (DWI) in assessing and quantifying hepatic fibrosis. METHODS: Thirty rats were divided into the control group (n = 6) and the fibrosis experimental groups (n = 6 per group) with CCl4 administration for 2, 4, 6, and 8 weeks. Liver fibrosis stage (S) and necroinflammatory activity grade (G) were histopathologically determined. DKI and DWI were performed; mean apparent diffusion (MD), mean kurtosis (MK), and apparent diffusion coefficient (ADC) values were calculated...
November 19, 2016: Abdominal Radiology
https://www.readbyqxmd.com/read/27834215/diffusion-weighted-imaging-uncovers-likely-sources-of-processing-speed-deficits-in-schizophrenia
#2
Peter Kochunov, Laura M Rowland, Els Fieremans, Jelle Veraart, Neda Jahanshad, George Eskandar, Xiaoming Du, Florian Muellerklein, Anya Savransky, Dinesh Shukla, Hemalatha Sampath, Paul M Thompson, L Elliot Hong
Schizophrenia, a devastating psychiatric illness with onset in the late teens to early 20s, is thought to involve disrupted brain connectivity. Functional and structural disconnections of cortical networks may underlie various cognitive deficits, including a substantial reduction in the speed of information processing in schizophrenia patients compared with controls. Myelinated white matter supports the speed of electrical signal transmission in the brain. To examine possible neuroanatomical sources of cognitive deficits, we used a comprehensive diffusion-weighted imaging (DWI) protocol and characterized the white matter diffusion signals using diffusion kurtosis imaging (DKI) and permeability-diffusivity imaging (PDI) in patients (n = 74), their nonill siblings (n = 41), and healthy controls (n = 113)...
November 22, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27825037/evaluation-of-histopathological-changes-in-the-microstructure-at-the-center-and-periphery-of-glioma-tumors-using-diffusional-kurtosis-imaging
#3
Fuyan Li, Wenqi Shi, Dawei Wang, Yanjie Xu, Hongxia Li, Jingzhen He, Qingshi Zeng
OBJECTIVE: To explore the relationship between alterations in gliomas revealed by diffusional kurtosis imaging (DKI) and the histopathological microstructural changes. METHODS: Thirty-seven patients with cerebral gliomas underwent conventional MRI and DKI at 3.0T. Normalized fractional anisotropy (FA), mean diffusivity (MD) and mean kurtosis (MK) were compared in different regions of glioma tumors. Parameters with a high sensitivity and specificity regarding the discrimination of glioma grade were evaluated using receiver operating characteristic (ROC) curve analysis...
October 27, 2016: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/27796448/assessment-of-tissue-heterogeneity-using-diffusion-tensor-and-diffusion-kurtosis-imaging-for-grading-gliomas
#4
Rajikha Raja, Neelam Sinha, Jitender Saini, Anita Mahadevan, Kvl Narasinga Rao, Aarthi Swaminathan
INTRODUCTION: In this work, we aim to assess the significance of diffusion tensor imaging (DTI) and diffusion kurtosis imaging (DKI) parameters in grading gliomas. METHODS: Retrospective studies were performed on 53 subjects with gliomas belonging to WHO grade II (n = 19), grade III (n = 20) and grade IV (n = 14). Expert marked regions of interest (ROIs) covering the tumour on T2-weighted images. Statistical texture measures such as entropy and busyness calculated over ROIs on diffusion parametric maps were used to assess the tumour heterogeneity...
October 29, 2016: Neuroradiology
https://www.readbyqxmd.com/read/27784203/repetitive-model-of-mild-traumatic-brain-injury-produces-cortical-abnormalities-detectable-by-magnetic-resonance-diffusion-imaging-dti-dki-histopathology-and-behavior
#5
Fengshan Yu, Dinesh Shukla, Regina C Armstrong, Christina Marie Marion, Kryslaine L Radomski, Reed G Selwyn, Bernard Dardzinski
Non-invasive detection of mild traumatic brain injury (mTBI) is important for evaluating acute through chronic effects of head injuries, particularly after repetitive impacts. To better detect abnormalities from mTBI, we performed longitudinal studies (baseline, 3, 6, 42 days) using magnetic resonance diffusion tensor imaging (DTI) and diffusion kurtosis imaging (DKI) in adult mice after repetitive mTBI (r-mTBI; daily x 5), or sham procedure. This r-mTBI produced righting reflex delay and was first characterized in the corpus callosum to demonstrate low levels of axon damage, astrogliosis, and microglial activation, without microhemorrhages...
October 26, 2016: Journal of Neurotrauma
https://www.readbyqxmd.com/read/27769116/structure-reactivity-effects-on-intrinsic-primary-kinetic-isotope-effects-for-hydride-transfer-catalyzed-by-glycerol-3-phosphate-dehydrogenase
#6
Archie C Reyes, Tina L Amyes, John P Richard
Primary deuterium isotope effects (1°DKIE) on (kcat/KGA, M(-1)s(-1)) for dianion (X(2-)) activated hydride transfer from NADL to glycolaldehyde (GA) catalyzed by glycerol 3-phosphate dehydrogenase are reported: (X(2-), 1°DKIE); FPO3(2-), 2.8 ± 0.1; HPO3(2-), 2.5 ± 0.1; SO4(2-), 2.8 ± 0.2; HOPO3(2-), 2.5 ± 0.1; S2O3(2-), 2.9 ± 0.1; unactivated; 2.4 ± 0.2. The 1°DKIEs on kcat are similar, consistent with fast and reversible ligand binding, and the conclusion that the observed 1°DKIEs are equal to the intrinsic 1°DKIE...
October 21, 2016: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/27758016/diffusion-kurtosis-imaging-for-differentiating-between-the-benign-and-malignant-sinonasal-lesions
#7
Jing Xuan Jiang, Zuo Hua Tang, Yu Feng Zhong, Jin Wei Qiang
PURPOSE: The study aimed to evaluate diffusion kurtosis imaging (DKI) in the differentiation between benign and malignant sinonasal lesions, and to compare the diagnostic performance of DKI with diffusion weighted imaging (DWI). MATERIALS AND METHODS: Eight-one patients with solid sinonasal lesions confirmed by surgery and pathology (46 malignant and 35 benign) underwent conventional MRI, DWI, and DKI. DKI was performed employing a 13 extended b-value ranging from 0 to 2500 s/mm(2) ...
October 19, 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27731906/fast-diffusion-kurtosis-imaging-of-fibrotic-mouse-kidneys
#8
B F Kjølby, A R Khan, A Chuhutin, L Pedersen, J B Jensen, S Jakobsen, D Zeidler, R Sangill, J R Nyengaard, S N Jespersen, B Hansen
Diffusion kurtosis imaging (DKI) is sensitive to tissue microstructure and may therefore be useful in the diagnosis and monitoring of disease in brain and body organs. Generally, diffusion magnetic resonance imaging (dMRI) in the body is challenging because of the heterogeneous body composition, which can cause image artefacts as a result of chemical shifts and susceptibility differences. In addition, the abdomen possesses physiological factors (e.g. breathing, heartbeat, blood flow) which may severely reduce image quality, especially when echo planar imaging is employed, as is typical in dMRI...
December 2016: NMR in Biomedicine
https://www.readbyqxmd.com/read/27696558/fast-diffusion-kurtosis-imaging-dki-with-inherent-correlation-based-normalization-icon-enhances-automatic-segmentation-of-heterogeneous-diffusion-mri-lesion-in-acute-stroke
#9
Iris Yuwen Zhou, Yingkun Guo, Takahiro Igarashi, Yu Wang, Emiri Mandeville, Suk-Tak Chan, Lingyi Wen, Mark Vangel, Eng H Lo, Xunming Ji, Phillip Zhe Sun
Diffusion kurtosis imaging (DKI) has been shown to augment diffusion-weighted imaging (DWI) for the definition of irreversible ischemic injury. However, the complexity of cerebral structure/composition makes the kurtosis map heterogeneous, limiting the specificity of kurtosis hyperintensity to acute ischemia. We propose an Inherent COrrelation-based Normalization (ICON) analysis to suppress the intrinsic kurtosis heterogeneity for improved characterization of heterogeneous ischemic tissue injury. Fast DKI and relaxation measurements were performed on normal (n = 10) and stroke rats following middle cerebral artery occlusion (MCAO) (n = 20)...
December 2016: NMR in Biomedicine
https://www.readbyqxmd.com/read/27693403/imaging-the-transformation-of-ipsilateral-internal-capsule-following-focal-cerebral-ischemia-in-rat-by-diffusion-kurtosis-imaging
#10
Xiao-Xue Zhang, Le-Kang Yin, Xiao-Zhu Hao, Jia-Qi Tian, Chan-Chan Li, Xiao-Yuan Feng, Yan-Mei Yang
BACKGROUND: The purpose of our study is to explore the relationship between recovery of neural function and transformation of the internal capsule (IC) after transient middle cerebral artery occlusion (MCAO) by using diffusion kurtosis imaging (DKI). METHODS: Six male adult Sprague-Dawley rats implemented with transient MCAO were used in this study. Sensorimotor function was assessed according to repetitive behavioral testing on day 1, 3, 7, 14, and 28 after cerebral ischemia...
September 29, 2016: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/27639358/diffusion-kurtosis-metrics-as-biomarkers-of-microstructural-development-a-comparative-study-of-a-group-of-children-and-a-group-of-adults
#11
Farida Grinberg, Ivan I Maximov, Ezequiel Farrher, Irene Neuner, Laura Amort, Heike Thönneßen, Eileen Oberwelland, Kerstin Konrad, N Jon Shah
The most common modality of diffusion MRI used in the ageing and development studies is diffusion tensor imaging (DTI) providing two key measures, fractional anisotropy and mean diffusivity. Here, we investigated diffusional changes occurring between childhood (average age 10.3 years) and mitddle adult age (average age 54.3 years) with the help of diffusion kurtosis imaging (DKI), a recent novel extension of DTI that provides additional metrics quantifying non-Gaussianity of water diffusion in brain tissue...
September 14, 2016: NeuroImage
https://www.readbyqxmd.com/read/27631106/the-value-of-diffusion-kurtosis-magnetic-resonance-imaging-for-assessing-treatment-response-of-neoadjuvant-chemoradiotherapy-in-locally-advanced-rectal-cancer
#12
Jing Yu, Qing Xu, Jia-Cheng Song, Yan Li, Xin Dai, Dong-Ya Huang, Ling Zhang, Yang Li, Hai-Bin Shi
OBJECTIVES: To evaluate the feasibility and value of diffusion kurtosis (DK) imaging in assessing treatment response to neoadjuvant chemoradiotherapy (CRT) in patients with locally advanced rectal cancer (LARC). METHODS: Forty-one patients were included. All patients underwent pre- and post-CRT DCE-MRI on a 3.0-Tesla MRI scanner. Imaging indices (D app , K app and ADC values) were measured. Change value (∆X) and change ratio (r∆X) were calculated. Pathological tumour regression grade scores (Mandard) were the standard reference (good responders: pTRG 1-2; poor responders: pTRG 3-5)...
September 8, 2016: European Radiology
https://www.readbyqxmd.com/read/27604789/in-vivo-molecular-profiling-of-human-glioma-using-diffusion-kurtosis-imaging
#13
Johann-Martin Hempel, Sotirios Bisdas, Jens Schittenhelm, Cornelia Brendle, Benjamin Bender, Henk Wassmann, Marco Skardelly, Ghazaleh Tabatabai, Salvador Castaneda Vega, Ulrike Ernemann, Uwe Klose
The purpose of this study is to assess the diagnostic performance of diffusion kurtosis imaging (DKI) for in vivo molecular profiling of human glioma. Normalized mean kurtosis (MKn) and mean diffusivity (MDn) metrics from DKI were assessed in 50 patients with histopathologically confirmed glioma. The results were compared in regard to the WHO-based histological findings and molecular characteristics leading to integrated diagnosis (Haarlem Consensus): isocitrate-dehydrogenase (IDH1/2) mutation status, alpha-thalassemia/mental retardation syndrome X-linked (ATRX) expression, chromosome 1p/19q loss of heterozygosity (LOH), and O6-methylguanine DNA methyltransferase (MGMT) promoter methylation status...
September 7, 2016: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/27576023/data-for-evaluation-of-fast-kurtosis-strategies-b-value-optimization-and-exploration-of-diffusion-mri-contrast
#14
COMMENT
Brian Hansen, Sune Nørhøj Jespersen
Here we describe and provide diffusion magnetic resonance imaging (dMRI) data that was acquired in neural tissue and a physical phantom. Data acquired in biological tissue includes: fixed rat brain (acquired at 9.4 T) and spinal cord (acquired at 16.4 T) and in normal human brain (acquired at 3 T). This data was recently used for evaluation of diffusion kurtosis imaging (DKI) contrasts and for comparison to diffusion tensor imaging (DTI) parameter contrast. The data has also been used to optimize b-values for ex vivo and in vivo fast kurtosis imaging...
August 30, 2016: Scientific Data
https://www.readbyqxmd.com/read/27552827/multimodal-mri-for-early-diabetic-mild-cognitive-impairment-study-protocol-of-a-prospective-diagnostic-trial
#15
Ying Yu, Qian Sun, Lin-Feng Yan, Yu-Chuan Hu, Hai-Yan Nan, Yang Yang, Zhi-Cheng Liu, Wen Wang, Guang-Bin Cui
BACKGROUND: Type 2 diabetes mellitus (T2DM) is a risk factor for dementia. Mild cognitive impairment (MCI), an intermediary state between normal cognition and dementia, often occurs during the prodromal diabetic stage, making early diagnosis and intervention of MCI very important. Latest neuroimaging techniques revealed some underlying microstructure alterations for diabetic MCI, from certain aspects. But there still lacks an integrated multimodal MRI system to detect early neuroimaging changes in diabetic MCI patients...
August 24, 2016: BMC Medical Imaging
https://www.readbyqxmd.com/read/27539807/fast-imaging-of-mean-axial-and-radial-diffusion-kurtosis
#16
Brian Hansen, Noam Shemesh, Sune Nørhøj Jespersen
Diffusion kurtosis imaging (DKI) is being increasingly reported to provide sensitive biomarkers of subtle changes in tissue microstructure. However, DKI also imposes larger data requirements than diffusion tensor imaging (DTI), hence, the widespread adaptation and exploration of DKI would benefit from more efficient acquisition and computational methods. To meet this demand, we recently developed a method capable of estimating mean kurtosis with only 13 diffusion weighted images. This approach was later shown to provide very accurate mean kurtosis estimates and to be more efficient in terms of contrast to noise per unit time...
August 15, 2016: NeuroImage
https://www.readbyqxmd.com/read/27538923/effects-of-perfusion-on-dti-and-dki-estimates-in-the-skeletal-muscle
#17
Alberto De Luca, Alessandra Bertoldo, Martijn Froeling
PURPOSE: In this study, we evaluated the effects of perfusion of the skeletal muscle on diffusion tensor imaging (DTI) and diffusional kurtosis imaging (DKI) parameters and their reproducibility. METHODS: Diffusion tensor imaging and DKI models, with and without intravoxel incoherent motion (IVIM) correction, were applied to simulated data at different physiological conditions and signal-to-noise ratio levels. Next, the same models were applied to data of the right calf of five healthy volunteers, acquired twice at 3 telsa...
August 19, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/27514570/diffusion-kurtosis-imaging-study-on-temporal-lobe-after-nasopharyngeal-carcinoma-radiotherapy
#18
Dan Wang, Yue-Hua Li, Jie Fu, He Wang
PURPOSE: Diffusion kurtosis imaging (DKI) is a MRI technique which can measure alterations in the diffusion of water molecules to reflect tissue changes in both white and grey matter. This study evaluated the potential of DKI for the early diagnosis of radiation-induced temporal lobe changes in the grey and white matter of the temporal lobe in patients with nasopharyngeal carcinoma (NPC). MATERIALS AND METHODS: Sixty patients with NPC who had normal MRI brain scans were enrolled and underwent DKI at 1 week (n=20), 6 months (n=20) or 1 year (n=20) after radiotherapy; 20 normal control individuals were also evaluated...
October 1, 2016: Brain Research
https://www.readbyqxmd.com/read/27499120/striatal-silent-lacunar-infarction-is-associated-with-changes-to-the-substantia-nigra-in-patients-with-early-stage-parkinson-s-disease-a-diffusion-kurtosis-imaging-study
#19
Guohua Zhang, Yuhu Zhang, Chengguo Zhang, Yukai Wang, Guixian Ma, Kun Nie, Haiqun Xie, Jianping Liu, Lijuan Wang
A recent study has shown that striatal silent infarction may occur secondary to the degeneration of dopaminergic neurons in the substantia nigra (SN) of mice. However, it is uncertain whether this phenomenon occurs in patients with early-stage Parkinson's disease (PD) and can be detected by diffusion kurtosis imaging (DKI). A total of 72 untreated patients with early-stage PD underwent conventional MRI and DKI. Participants were divided into control and striatal silent lacunar infarction (SSLI) groups. The differences in mean kurtosis (MK) values of the SN, Hoehn-Yahr (H-Y) staging, and Unified Parkinson's Disease Rating Scale (UPDRS) III score between groups, were analyzed...
November 2016: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/27476097/assessment-of-cochlear-nerve-deficiency-and-its-effect-on-normal-maturation-of-auditory-tract-by-diffusion-kurtosis-imaging-and-diffusion-tensor-imaging-a-correlational-approach
#20
Vijayakumar Chinnadurai, C M Sreedhar, Subash Khushu
OBJECTIVE: The use of diffusion kurtosis imaging (DKI) and diffusion tensor imaging (DTI) was evaluated in assessing cochlear nerve deficiency (CND) and its effect on normal maturation of auditory tract. METHODS: 25 CND patients and 25 controls (age matched: 2months to 17years, gender matched) were evaluated by mean kurtosis (MK), axial kurtosis, and radial kurtosis and compared against fractional anisotropy (FA), axial and radial diffusivities in internal auditory canal (IAC), lateral lemniscus (LL) and inferior colliculus (IC)...
November 2016: Magnetic Resonance Imaging
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