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https://www.readbyqxmd.com/read/29470156/journal-club-evaluation-of-diffusion-kurtosis-imaging-of-stroke-lesion-with-hemodynamic-and-metabolic-mri-in-a-rodent-model-of-acute-stroke
#1
Dongshuang Lu, Yinghua Jiang, Yang Ji, Iris Yuwen Zhou, Emiri Mandeville, Eng H Lo, Xiaoying Wang, Phillip Zhe Sun
OBJECTIVE: Diffusion kurtosis imaging (DKI) has emerged as a new acute stroke imaging approach, augmenting routine DWI. Although it has been shown that a diffusion lesion without kurtosis abnormality is more likely to recover after reperfusion, whereas a kurtosis lesion shows poor response, little is known about the underlying pathophysiologic profile of the kurtosis lesion versus the kurtosis lesion-diffusion lesion mismatch. MATERIALS AND METHODS: We performed multiparametric MRI, including arterial spin labeling, pH-sensitive amide proton transfer, and DKI, in a rodent model of acute stroke caused by embolic middle cerebral artery occlusion...
February 22, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29459137/microstructural-visual-pathway-abnormalities-in-patients-with-primary-glaucoma-3-t-diffusion-kurtosis-imaging-study
#2
Z F Xu, J S Sun, X H Zhang, Y Y Feng, A Z Pan, M Y Gao, H Zhao
AIM: To evaluate microstructural visual pathway damage in patients with primary glaucoma (PG) by using 3 T diffusion kurtosis imaging (DKI). MATERIALS AND METHODS: The study was approved by the ethics committee, and all participants provided written informed consent. Ten patients with PG were examined. Twenty healthy individuals served as control subjects. DKI was performed with a GE Silent 3 T magnetic resonance imaging (MRI) unit. Mean diffusivity (MD), fractional anisotropy (FA), and mean kurtosis (MK) maps were automatically created...
February 16, 2018: Clinical Radiology
https://www.readbyqxmd.com/read/29453439/working-memory-and-brain-tissue-microstructure-white-matter-tract-integrity-based-on-multi-shell-diffusion-mri
#3
Sohae Chung, Els Fieremans, Nuri E Kucukboyaci, Xiuyuan Wang, Charles J Morton, Dmitry S Novikov, Joseph F Rath, Yvonne W Lui
Working memory is a complex cognitive process at the intersection of sensory processing, learning, and short-term memory and also has a general executive attention component. Impaired working memory is associated with a range of neurological and psychiatric disorders, but very little is known about how working memory relates to underlying white matter (WM) microstructure. In this study, we investigate the association between WM microstructure and performance on working memory tasks in healthy adults (right-handed, native English speakers)...
February 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29438595/effects-of-early-alcohol-exposure-on-functional-organization-and-microstructure-of-a-visual-tactile-integrative-circuit
#4
Shiyu Tang, Su Xu, Rao P Gullapalli, Alexandre E Medina
BACKGROUND: Children with fetal alcohol spectrum disorders (FASD) often have deficits associated with multisensory processing. Because ethanol disrupts activity-dependent neuronal plasticity, a process that is essential for refining connections during cortical development, we hypothesize that early alcohol exposure results in alterations in multisensory cortical networks, which could explain the multisensory processing deficits seen in FASD. Here, we use a gyrencephalic animal model to test the prediction that early alcohol exposure alters the functional connectivity and microstructural features of the rostral posterior parietal cortex (PPr), a visual-tactile integrative area...
February 13, 2018: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29433631/ampk-signaling-to-acetyl-coa-carboxylase-is-required-for-fasting-and-cold-induced-appetite-but-not-thermogenesis
#5
Sandra Galic, Kim Loh, Lisa Murray-Segal, Gregory R Steinberg, Zane B Andrews, Bruce E Kemp
AMP-activated protein kinase (AMPK) is a known regulator of whole-body energy homeostasis, but the downstream AMPK substrates mediating these effects are not entirely clear. AMPK inhibits fatty acid synthesis and promotes fatty acid oxidation by phosphorylation of acetyl-CoA carboxylase (ACC) 1 at Ser 79 and ACC2 at Ser 212 . Using mice with Ser 79 Ala/Ser 212 Ala knock-in mutations (ACC DKI) we find that inhibition of ACC phosphorylation leads to reduced appetite in response to fasting or cold exposure. At sub-thermoneutral temperatures, ACC DKI mice maintain normal energy expenditure and thermogenesis, but fail to increase appetite and lose weight...
February 13, 2018: ELife
https://www.readbyqxmd.com/read/29416777/staging-of-rat-liver-fibrosis-using-monoexponential-stretched-exponential-and-diffusion-kurtosis-models-with-diffusion-weighted-imaging-magnetic-resonance
#6
Genwen Hu, Wen Liang, Mingxiang Wu, Queenie Chan, Yufa Li, Jianmin Xu, Liangping Luo, Xianyue Quan
Early diagnosis of liver fibrosis is important. The objective of this study was to explore the characteristics and to assess the accuracy of monoexponential, stretched exponential models (SEM), and diffusion kurtosis imaging (DKI) with diffusion-weighted imaging (DWI)-magnetic resonance imaging (MRI) in various stages of liver fibrosis in two standard rat models induced by carbon tetrachloride (CCl4) and biliary duct ligation (BDL). Parameters (ADC, Dapp, Kapp, DDC, α) were measured with a 3.0T MRI. Liver fibrosis stages (F0-F4) were defined by METAVIR scoring...
January 5, 2018: Oncotarget
https://www.readbyqxmd.com/read/29416687/no-differences-in-brain-microstructure-between-young-kibra-c-carriers-and-non-carriers
#7
Li Hu, Qunxing Xu, Jizhen Li, Feifei Wang, Xinghua Xu, Zhiyuan Sun, Xiangxing Ma, Yong Liu, Qing Wang, Dawei Wang
KIBRA rs17070145 polymorphism is associated with variations in memory function and the microstructure of related brain areas. Diffusion kurtosis imaging (DKI) as an extension of diffusion tensor imaging that can provide more information about changes in microstructure, based on the idea that water diffusion in biological tissues is heterogeneous due to structural hindrance and restriction. We used DKI to explore the relationship between KIBRA gene polymorphism and brain microstructure in young adults. We recruited 100 healthy young volunteers, including 53 TT carriers and 47 C allele carriers...
January 2, 2018: Oncotarget
https://www.readbyqxmd.com/read/29393531/diffusion-kurtosis-imaging-with-free-water-elimination-a-bayesian-estimation-approach
#8
Quinten Collier, Jelle Veraart, Ben Jeurissen, Floris Vanhevel, Pim Pullens, Paul M Parizel, Arnold J den Dekker, Jan Sijbers
PURPOSE: Diffusion kurtosis imaging (DKI) is an advanced magnetic resonance imaging modality that is known to be sensitive to changes in the underlying microstructure of the brain. Image voxels in diffusion weighted images, however, are typically relatively large making them susceptible to partial volume effects, especially when part of the voxel contains cerebrospinal fluid. In this work, we introduce the "Diffusion Kurtosis Imaging with Free Water Elimination" (DKI-FWE) model that separates the signal contributions of free water and tissue, where the latter is modeled using DKI...
February 2, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29383522/staging-liver-fibrosis-with-dwi-is-there-an-added-value-for-diffusion-kurtosis-imaging
#9
Li Yang, Shengxiang Rao, Wentao Wang, Caizhong Chen, Ying Ding, Chun Yang, Robert Grimm, Xu Yan, Caixia Fu, Mengsu Zeng
OBJECTIVES: To assess liver fibrosis in patients with chronic liver disease using diffusion kurtosis imaging (DKI) in comparison with conventional diffusion-weighted imaging, with histology as reference standard. METHODS: This prospective study included 81 patients and DKI with b-values of 0, 200, 500, 1,000, 1,500, 2,000 s/mm2 were performed. Mean diffusivity (MD), mean kurtosis (MK) and apparent diffusion coefficient (ADC) maps were calculated. The diagnostic efficacy of MD, MK and ADC for predicting stage 2 fibrosis or greater, and stage 3 fibrosis or greater were compared...
January 30, 2018: European Radiology
https://www.readbyqxmd.com/read/29383521/standard-diffusion-weighted-diffusion-kurtosis-and-intravoxel-incoherent-motion-mr-imaging-of-sinonasal-malignancies-correlations-with-ki-67-proliferation-status
#10
Zebin Xiao, Yufeng Zhong, Zuohua Tang, Jinwei Qiang, Wen Qian, Rong Wang, Jie Wang, Lingjie Wu, Wenlin Tang, Zhongshuai Zhang
OBJECTIVES: To explore the correlations of parameters derived from standard diffusion-weighted imaging (DWI), diffusion kurtosis imaging (DKI) and intravoxel incoherent motion (IVIM) with the Ki-67 proliferation status. METHODS: Seventy-five patients with histologically proven sinonasal malignancies who underwent standard DWI, DKI and IVIM were retrospectively reviewed. The mean, minimum, maximum and whole standard DWI [apparent diffusion coefficient (ADC)], DKI [diffusion kurtosis (K) and diffusion coefficient (Dk)] and IVIM [pure diffusion coefficient (D), pseudo-diffusion coefficient (D*) and perfusion fraction (f)] parameters were measured and correlated with the Ki-67 labelling index (LI)...
January 30, 2018: European Radiology
https://www.readbyqxmd.com/read/29380545/diffusion-kurtosis-imaging-shows-similar-cerebral-axonal-damage-in-patients-with-hiv-infection-and-multiple-sclerosis
#11
Korhan Buyukturkoglu, Lazar Fleyser, Desiree Byrd, Susan Morgello, Matilde Inglese
BACKGROUND AND PURPOSE: In this pilot study, we sought to investigate the pathological changes in the white matter (WM) of medically complex, combination antiretroviral therapy (cART)-treated patients with human immunodeficiency virus (HIV), comparing them to patients with long-standing, secondary progressive multiple sclerosis (SPMS). METHODS: Using diffusion kurtosis imaging (DKI)-derived WM tract integrity (WMTI) metrics, 15 HIV and 15 age- and sex-matched SPMS patients with similar disease duration underwent magnetic resonance imaging analysis...
January 30, 2018: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/29378223/principles-of-diffusion-kurtosis-imaging-and-its-role-in-early-diagnosis-of-neurodegenerative-disorders
#12
REVIEW
Anas Arab, Anna Wojna-Pelczar, Amit Khairnar, Nikoletta Szabó, Jana Ruda-Kucerova
Pathology of neurodegenerative diseases can be correlated with intra-neuronal as well as extracellular changes which lead to neuronal degeneration. The central nervous system (CNS) is a complex structure comprising of many biological barriers. These microstructural barriers might be affected by a variety of pathological processes. Specifically, changes in the brain tissue's microstructure affect the diffusion of water which can be assessed non-invasively by diffusion weighted (DW) magnetic resonance imaging (MRI) techniques...
January 26, 2018: Brain Research Bulletin
https://www.readbyqxmd.com/read/29370870/diffusion-kurtosis-imaging-allows-the-early-detection-and-longitudinal-follow-up-of-amyloid-%C3%AE-induced-pathology
#13
Jelle Praet, Nikolay V Manyakov, Leacky Muchene, Zhenhua Mai, Vasilis Terzopoulos, Steve de Backer, An Torremans, Pieter-Jan Guns, Tom Van De Casteele, Astrid Bottelbergs, Bianca Van Broeck, Jan Sijbers, Dirk Smeets, Ziv Shkedy, Luc Bijnens, Darrel J Pemberton, Mark E Schmidt, Annemie Van der Linden, Marleen Verhoye
BACKGROUND: Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia in the elderly population. In this study, we used the APP/PS1 transgenic mouse model to explore the feasibility of using diffusion kurtosis imaging (DKI) as a tool for the early detection of microstructural changes in the brain due to amyloid-β (Aβ) plaque deposition. METHODS: We longitudinally acquired DKI data of wild-type (WT) and APP/PS1 mice at 2, 4, 6 and 8 months of age, after which these mice were sacrificed for histological examination...
January 9, 2018: Alzheimer's Research & Therapy
https://www.readbyqxmd.com/read/29368035/alteration-of-putaminal-fractional-anisotropy-in-parkinson-s-disease-a-longitudinal-diffusion-kurtosis-imaging-study
#14
Yulia Surova, Markus Nilsson, Björn Lampinen, Jimmy Lätt, Sara Hall, Håkan Widner, Danielle van Westen, Oskar Hansson
PURPOSE: In Parkinson's disease (PD), pathological microstructural changes occur that may be detected using diffusion magnetic resonance imaging (dMRI). However, there are few longitudinal studies that explore the effect of disease progression on diffusion indices. METHODS: We prospectively included 76 patients with PD and 38 healthy controls (HC), all of whom underwent diffusion kurtosis imaging (DKI) as part of the prospective Swedish BioFINDER study at baseline and 2 years later...
January 24, 2018: Neuroradiology
https://www.readbyqxmd.com/read/29305126/assessing-diffusion-kurtosis-tensor-estimation-methods-using-a-digital-brain-phantom-derived-from-human-connectome-project-data
#15
Daniel V Olson, Volkan E Arpinar, L Tugan Muftuler
PURPOSE: Diffusion kurtosis imaging (DKI) has gained popularity in recent years as an advanced diffusion-weighted MRI technique. This work aims to quantitatively compare the performance and accuracy of four DKI processing algorithms. For this purpose, a digital DKI brain phantom is developed. METHODS: Data from the Human Connectome Project database were used to generate a DKI digital phantom. In a Monte Carlo Rician noise simulation, four DKI processing algorithms were compared based on their mean squared error, squared bias, and variance...
January 3, 2018: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29275590/-parkinson-s-disease-diffusion-kurtosis-imaging-and-the-correlation-with-clinical-manifestations
#16
Y Q Sun, Q Zhang, Z Jiang, C Y Zhang, J W Zhang, H Chen, J K Shen
Objective: Using magnetic resonance diffusion kurtosis imaging (DKI) to evaluate the microstructure changes of deep brain nucleus in Parkinson's disease (PD) as well as the correlation with clinical manifestations. Methods: Thirty-two PD patients were recruited into this study. Twenty gender and age matched healthy subjects served as the control group. All participants underwent MRI examinations, including T(1)WI, T(2)WI, DWI, susceptibility weighted imaging (SWI) and DKI. The original DKI imaging data were processed offline to calculate two parametric maps, including mean kurtosis (MK) value and fractional anisotropy (FA) value...
December 5, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29232021/investigation-of-diffusion-kurtosis-imaging-for-discriminating-tumors-from-inflammatory-lesions-after-treatment-for-bladder-cancer
#17
Fang Wang, Di Jin, Xiao-Lan Hua, Zi-Zhou Zhao, Lian-Ming Wu, Wei-Bo Chen, Guang-Yu Wu, Xiao-Xi Chen, Hai-Ge Chen
BACKGROUND: The bladder wall may thicken resulting from chronic inflammation after initial treatment (transurethral resection [TUR] or neoadjuvant chemotherapy), which may mimic the feature of recurrent or residual bladder tumors (RBT). Therefore, it is critical to discriminate RBT from benign lesions after initial treatment. PURPOSE: To investigate whether diffusion kurtosis imaging (DKI) could discriminate RBT from post-therapy bladder inflammatory lesions. STUDY TYPE: Retrospective...
December 12, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29222677/diagnostic-evaluation-of-magnetization-transfer-and-diffusion-kurtosis-imaging-for-prostate-cancer-detection-in-a-re-biopsy-population
#18
Tristan Barrett, Mary McLean, Andrew N Priest, Edward M Lawrence, Andrew J Patterson, Brendan C Koo, Ilse Patterson, Anne Y Warren, Andrew Doble, Vincent J Gnanapragasam, Christof Kastner, Ferdia A Gallagher
OBJECTIVE: To evaluate diffusion kurtosis imaging (DKI) and magnetisation transfer imaging (MTI) compared to standard MRI for prostate cancer assessment in a re-biopsy population. METHODS: Thirty-patients were imaged at 3 T including DKI (Kapp and Dapp) with b-values 150/450/800/1150/1500 s/mm2 and MTI performed with and without MT saturation. Patients underwent transperineal biopsy based on prospectively defined MRI targets. Receiver-operating characteristic (ROC) analyses assessed the parameters and Wilcoxon-signed ranked test assessed relationships between metrics...
December 8, 2017: European Radiology
https://www.readbyqxmd.com/read/29221965/diffusion-kurtosis-imaging-of-a-human-nasopharyngeal-carcinoma-xenograft-model-initial-experience-with-pathological-correlation
#19
Jing Zhong, Peng Shi, Yunbin Chen, Rongfang Huang, Youping Xiao, Xiang Zheng, Dechun Zheng, Li Peng
PURPOSE: The aim of this study was to investigate the relationship between diffusion kurtosis imaging (DKI)-related parameters and pathological measures using human nasopharyngeal carcinoma (NPC) xenografts in a nude mouse model. MATERIALS AND METHODS: Twenty-six BALB/c-nu nude mice were divided into two groups that were injected with two different nasopharyngeal squamous cell carcinoma cell lines (CNE1 and CNE2). DK magnetic resonance (MR) imaging was performed on a 3...
December 6, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29213008/the-relationship-between-neurite-density-measured-with-confocal-microscopy-in-a-cleared-mouse-brain-and-metrics-obtained-from-diffusion-tensor-and-diffusion-kurtosis-imaging
#20
Ryusuke Irie, Koji Kamagata, Aurelien Kerever, Ryo Ueda, Suguru Yokosawa, Yosuke Otake, Hisaaki Ochi, Hidekazu Yoshizawa, Ayato Hayashi, Kazuhiko Tagawa, Hitoshi Okazawa, Kohske Takahashi, Kanako Sato, Masaaki Hori, Eri Arikawa-Hirasawa, Shigeki Aoki
PURPOSE: Diffusional kurtosis imaging (DKI) enables sensitive measurement of tissue microstructure by quantifying the non-Gaussian diffusion of water. Although DKI is widely applied in many situations, histological correlation with DKI analysis is lacking. The purpose of this study was to determine the relationship between DKI metrics and neurite density measured using confocal microscopy of a cleared mouse brain. METHODS: One thy-1 yellow fluorescent protein 16 mouse was deeply anesthetized and perfusion fixation was performed...
December 7, 2017: Magnetic Resonance in Medical Sciences: MRMS
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