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https://www.readbyqxmd.com/read/29676939/diffusion-kurtosis-imaging-in-the-differential-diagnosis-of-parotid-gland-disease-and-parotid-adenolymphoma-preliminary-results
#1
Shun Yu, Zhongshuai Zhang, Bao Qiang, S U Jiawei, Mengxiao Liu, Qinglei Shi, Wenchao Cai
PURPOSE: To study the value of diffusion kurtosis imaging (DKI) in diagnosis of parotid gland disease (PGD) with different pathological patterns and parotid adenolymphoma (PAL). METHODS: Fifty-seven patients with different kinds of PGD were enrolled and underwent DKI and conventional diffusion-weighted imaging (DWI). All patients were categorized into different groups according to their pathological patterns. The result of calculating the value of DKI-derived parameters (Kmean, Krad, Kax, Dmean, Drad, Dax, and FA) and apparent diffusion coefficient (ADC) of DWI were used to study their diagnostic accuracy in PGD with different pathological patterns...
April 20, 2018: Dento Maxillo Facial Radiology
https://www.readbyqxmd.com/read/29671924/effects-of-syn1-q555x-mutation-on-cortical-gray-matter-microstructure
#2
Jean-François Cabana, Guillaume Gilbert, Laurent Létourneau-Guillon, Dima Safi, Isabelle Rouleau, Patrick Cossette, Dang Khoa Nguyen
A new Q555X mutation on the SYN1 gene was recently found in several members of a family segregating dyslexia, epilepsy, and autism spectrum disorder. To describe the effects of this mutation on cortical gray matter microstructure, we performed a surface-based group study using novel diffusion and quantitative multiparametric imaging on 13 SYN1Q555X mutation carriers and 13 age- and sex-matched controls. Specifically, diffusion kurtosis imaging (DKI) and neurite orientation and dispersion and density imaging (NODDI) were used to analyze multi-shell diffusion data and obtain parametric maps sensitive to tissue structure, while quantitative metrics sensitive to tissue composition (T1, T2* and relative proton density [PD]) were obtained from a multi-echo variable flip angle FLASH acquisition...
April 19, 2018: Human Brain Mapping
https://www.readbyqxmd.com/read/29666413/texture-analysis-and-support-vector-machine-assisted-diffusional-kurtosis-imaging-may-allow-in-vivo-gliomas-grading-and-idh-mutation-status-prediction-a-preliminary-study
#3
Sotirios Bisdas, Haocheng Shen, Steffi Thust, Vasileios Katsaros, George Stranjalis, Christos Boskos, Sebastian Brandner, Jianguo Zhang
We sought to investigate, whether texture analysis of diffusional kurtosis imaging (DKI) enhanced by support vector machine (SVM) analysis may provide biomarkers for gliomas staging and detection of the IDH mutation. First-order statistics and texture feature extraction were performed in 37 patients on both conventional (FLAIR) and mean diffusional kurtosis (MDK) images and recursive feature elimination (RFE) methodology based on SVM was employed to select the most discriminative diagnostic biomarkers. The first-order statistics demonstrated significantly lower MDK values in the IDH-mutant tumors...
April 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29573042/value-of-diffusion-kurtosis-imaging-in-assessing-low-grade-gliomas
#4
Mohammed Z Goryawala, Deborah O Heros, Ricardo J Komotar, Sulaiman Sheriff, Efrat Saraf-Lavi, Andrew A Maudsley
BACKGROUND: Diffusion kurtosis imaging (DKI) measures have been shown to provide increased sensitivity relative to diffusion tensor imaging (DTI) in detecting pathologies. PURPOSE: To compare the sensitivity of DKI-derived kurtosis and diffusion maps for assessment of low-grade gliomas (LGG). STUDY TYPE: Prospective study. POPULATION: In all, 19 LGG patients and 26 healthy control subjects were recruited. FIELD STRENGTH/SEQUENCE: Echo-planar-imaging diffusion-weighted MR images (b-values = 0, 1000, and 2000 with 30 diffusion gradient directions) were acquired on a 3T scanner...
March 23, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29558293/diffusion-kurtosis-imaging-of-acute-infarction-comparison-with-routine-diffusion-and-follow-up-mr-imaging
#5
Jianzhong Yin, Haizhen Sun, Zhiyun Wang, Hongyan Ni, Wen Shen, Phillip Zhe Sun
Purpose To determine the relationship between diffusion-weighted imaging (DWI) and diffusion kurtosis imaging (DKI) in patients with acute stroke at admission and the tissue outcome 1 month after onset of stroke. Materials and Methods Patients with stroke underwent DWI (b values = 0, 1000 sec/mm2 along three directions) and DKI (b values = 0, 1000, 2000 sec/mm2 along 20 directions) within 24 hours after symptom onset and 1 month after symptom onset. For large lesions (diameter ≥ 1 cm), acute lesion volumes at DWI and DKI were compared with those at follow-up T2-weighted imaging by using Spearman correlation analysis...
March 20, 2018: Radiology
https://www.readbyqxmd.com/read/29486596/a-comparative-study-of-gaussian-and-non-gaussian-diffusion-models-for-differential-diagnosis-of-prostate-cancer-with-in-bore-transrectal-mr-guided-biopsy-as-a-pathological-reference
#6
Chunmei Li, Min Chen, Ben Wan, Jingying Yu, Ming Liu, Wei Zhang, Jianye Wang
Background Although several studies have been reported on evaluating the performance of Gaussian and different non-Gaussian diffusion models on prostate cancer, few studies have been reported on the comparison of different models on differential diagnosis for prostate cancer. Purpose To compare the utility of various metrics derived from monoexponential model (MEM), biexponential model (BEM), stretched-exponential model (SEM) based diffusion-weighted imaging (DWI) and diffusion kurtosis imaging (DKI) in the differential diagnosis of prostate cancer...
January 1, 2018: Acta Radiologica
https://www.readbyqxmd.com/read/29482345/subcortical-nuclei-in-alzheimer-s-disease-a-volumetric-and-diffusion-kurtosis-imaging-study
#7
Ming-Liang Wang, Xiao-Er Wei, Jian-Liang Fu, Wei Li, Meng-Meng Yu, Peng-Yang Li, Wen-Bin Li
Background Previous studies revealed that subcortical nuclei were harmed in the process of Alzheimer's disease (AD). Purpose To investigate the volumetric and diffusion kurtosis imaging (DKI) parameter changes of subcortical nuclei in AD and their relationship with cognitive function. Materials and Methods A total of 17 mild AD patients, 15 moderate to severe AD patients, and 16 controls underwent neuropsychological tests and magnetic resonance imaging (MRI) scans. Volume, mean kurtosis (MK), mean diffusivity (MD), and fractional anisotropy (FA) were measured in hippocampus, thalamus, caudate, putamen, pallidum, and amygdala...
January 1, 2018: Acta Radiologica
https://www.readbyqxmd.com/read/29470156/journal-club-evaluation-of-diffusion-kurtosis-imaging-of-stroke-lesion-with-hemodynamic-and-metabolic-mri-in-a-rodent-model-of-acute-stroke
#8
Dongshuang Lu, Yinghua Jiang, Yang Ji, Iris Yuwen Zhou, Emiri Mandeville, Eng H Lo, Xiaoying Wang, Phillip Zhe Sun
OBJECTIVE: Diffusion kurtosis imaging (DKI) has emerged as a new acute stroke imaging approach, augmenting routine DWI. Although it has been shown that a diffusion lesion without kurtosis abnormality is more likely to recover after reperfusion, whereas a kurtosis lesion shows poor response, little is known about the underlying pathophysiologic profile of the kurtosis lesion versus the kurtosis lesion-diffusion lesion mismatch. MATERIALS AND METHODS: We performed multiparametric MRI, including arterial spin labeling, pH-sensitive amide proton transfer, and DKI, in a rodent model of acute stroke caused by embolic middle cerebral artery occlusion...
February 22, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29459137/microstructural-visual-pathway-abnormalities-in-patients-with-primary-glaucoma-3-t-diffusion-kurtosis-imaging-study
#9
Z F Xu, J S Sun, X H Zhang, Y Y Feng, A Z Pan, M Y Gao, H Zhao
AIM: To evaluate microstructural visual pathway damage in patients with primary glaucoma (PG) by using 3 T diffusion kurtosis imaging (DKI). MATERIALS AND METHODS: The study was approved by the ethics committee, and all participants provided written informed consent. Ten patients with PG were examined. Twenty healthy individuals served as control subjects. DKI was performed with a GE Silent 3 T magnetic resonance imaging (MRI) unit. Mean diffusivity (MD), fractional anisotropy (FA), and mean kurtosis (MK) maps were automatically created...
February 16, 2018: Clinical Radiology
https://www.readbyqxmd.com/read/29453439/working-memory-and-brain-tissue-microstructure-white-matter-tract-integrity-based-on-multi-shell-diffusion-mri
#10
Sohae Chung, Els Fieremans, Nuri E Kucukboyaci, Xiuyuan Wang, Charles J Morton, Dmitry S Novikov, Joseph F Rath, Yvonne W Lui
Working memory is a complex cognitive process at the intersection of sensory processing, learning, and short-term memory and also has a general executive attention component. Impaired working memory is associated with a range of neurological and psychiatric disorders, but very little is known about how working memory relates to underlying white matter (WM) microstructure. In this study, we investigate the association between WM microstructure and performance on working memory tasks in healthy adults (right-handed, native English speakers)...
February 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29438595/effects-of-early-alcohol-exposure-on-functional-organization-and-microstructure-of-a-visual-tactile-integrative-circuit
#11
Shiyu Tang, Su Xu, Rao P Gullapalli, Alexandre E Medina
BACKGROUND: Children with fetal alcohol spectrum disorders (FASD) often have deficits associated with multisensory processing. Because ethanol disrupts activity-dependent neuronal plasticity, a process that is essential for refining connections during cortical development, we hypothesize that early alcohol exposure results in alterations in multisensory cortical networks, which could explain the multisensory processing deficits seen in FASD. Here, we use a gyrencephalic animal model to test the prediction that early alcohol exposure alters the functional connectivity and microstructural features of the rostral posterior parietal cortex (PPr), a visual-tactile integrative area...
February 13, 2018: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29433631/ampk-signaling-to-acetyl-coa-carboxylase-is-required-for-fasting-and-cold-induced-appetite-but-not-thermogenesis
#12
Sandra Galic, Kim Loh, Lisa Murray-Segal, Gregory R Steinberg, Zane B Andrews, Bruce E Kemp
AMP-activated protein kinase (AMPK) is a known regulator of whole-body energy homeostasis, but the downstream AMPK substrates mediating these effects are not entirely clear. AMPK inhibits fatty acid synthesis and promotes fatty acid oxidation by phosphorylation of acetyl-CoA carboxylase (ACC) 1 at Ser 79 and ACC2 at Ser 212 . Using mice with Ser 79 Ala/Ser 212 Ala knock-in mutations (ACC DKI) we find that inhibition of ACC phosphorylation leads to reduced appetite in response to fasting or cold exposure. At sub-thermoneutral temperatures, ACC DKI mice maintain normal energy expenditure and thermogenesis, but fail to increase appetite and lose weight...
February 13, 2018: ELife
https://www.readbyqxmd.com/read/29416777/staging-of-rat-liver-fibrosis-using-monoexponential-stretched-exponential-and-diffusion-kurtosis-models-with-diffusion-weighted-imaging-magnetic-resonance
#13
Genwen Hu, Wen Liang, Mingxiang Wu, Queenie Chan, Yufa Li, Jianmin Xu, Liangping Luo, Xianyue Quan
Early diagnosis of liver fibrosis is important. The objective of this study was to explore the characteristics and to assess the accuracy of monoexponential, stretched exponential models (SEM), and diffusion kurtosis imaging (DKI) with diffusion-weighted imaging (DWI)-magnetic resonance imaging (MRI) in various stages of liver fibrosis in two standard rat models induced by carbon tetrachloride (CCl4) and biliary duct ligation (BDL). Parameters (ADC, Dapp, Kapp, DDC, α) were measured with a 3.0T MRI. Liver fibrosis stages (F0-F4) were defined by METAVIR scoring...
January 5, 2018: Oncotarget
https://www.readbyqxmd.com/read/29416687/no-differences-in-brain-microstructure-between-young-kibra-c-carriers-and-non-carriers
#14
Li Hu, Qunxing Xu, Jizhen Li, Feifei Wang, Xinghua Xu, Zhiyuan Sun, Xiangxing Ma, Yong Liu, Qing Wang, Dawei Wang
KIBRA rs17070145 polymorphism is associated with variations in memory function and the microstructure of related brain areas. Diffusion kurtosis imaging (DKI) as an extension of diffusion tensor imaging that can provide more information about changes in microstructure, based on the idea that water diffusion in biological tissues is heterogeneous due to structural hindrance and restriction. We used DKI to explore the relationship between KIBRA gene polymorphism and brain microstructure in young adults. We recruited 100 healthy young volunteers, including 53 TT carriers and 47 C allele carriers...
January 2, 2018: Oncotarget
https://www.readbyqxmd.com/read/29393531/diffusion-kurtosis-imaging-with-free-water-elimination-a-bayesian-estimation-approach
#15
Quinten Collier, Jelle Veraart, Ben Jeurissen, Floris Vanhevel, Pim Pullens, Paul M Parizel, Arnold J den Dekker, Jan Sijbers
PURPOSE: Diffusion kurtosis imaging (DKI) is an advanced magnetic resonance imaging modality that is known to be sensitive to changes in the underlying microstructure of the brain. Image voxels in diffusion weighted images, however, are typically relatively large making them susceptible to partial volume effects, especially when part of the voxel contains cerebrospinal fluid. In this work, we introduce the "Diffusion Kurtosis Imaging with Free Water Elimination" (DKI-FWE) model that separates the signal contributions of free water and tissue, where the latter is modeled using DKI...
February 2, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29383522/staging-liver-fibrosis-with-dwi-is-there-an-added-value-for-diffusion-kurtosis-imaging
#16
Li Yang, Shengxiang Rao, Wentao Wang, Caizhong Chen, Ying Ding, Chun Yang, Robert Grimm, Xu Yan, Caixia Fu, Mengsu Zeng
OBJECTIVES: To assess liver fibrosis in patients with chronic liver disease using diffusion kurtosis imaging (DKI) in comparison with conventional diffusion-weighted imaging, with histology as reference standard. METHODS: This prospective study included 81 patients and DKI with b-values of 0, 200, 500, 1,000, 1,500, 2,000 s/mm2 were performed. Mean diffusivity (MD), mean kurtosis (MK) and apparent diffusion coefficient (ADC) maps were calculated. The diagnostic efficacy of MD, MK and ADC for predicting stage 2 fibrosis or greater, and stage 3 fibrosis or greater were compared...
January 30, 2018: European Radiology
https://www.readbyqxmd.com/read/29383521/standard-diffusion-weighted-diffusion-kurtosis-and-intravoxel-incoherent-motion-mr-imaging-of-sinonasal-malignancies-correlations-with-ki-67-proliferation-status
#17
Zebin Xiao, Yufeng Zhong, Zuohua Tang, Jinwei Qiang, Wen Qian, Rong Wang, Jie Wang, Lingjie Wu, Wenlin Tang, Zhongshuai Zhang
OBJECTIVES: To explore the correlations of parameters derived from standard diffusion-weighted imaging (DWI), diffusion kurtosis imaging (DKI) and intravoxel incoherent motion (IVIM) with the Ki-67 proliferation status. METHODS: Seventy-five patients with histologically proven sinonasal malignancies who underwent standard DWI, DKI and IVIM were retrospectively reviewed. The mean, minimum, maximum and whole standard DWI [apparent diffusion coefficient (ADC)], DKI [diffusion kurtosis (K) and diffusion coefficient (Dk)] and IVIM [pure diffusion coefficient (D), pseudo-diffusion coefficient (D*) and perfusion fraction (f)] parameters were measured and correlated with the Ki-67 labelling index (LI)...
January 30, 2018: European Radiology
https://www.readbyqxmd.com/read/29380545/diffusion-kurtosis-imaging-shows-similar-cerebral-axonal-damage-in-patients-with-hiv-infection-and-multiple-sclerosis
#18
Korhan Buyukturkoglu, Lazar Fleyser, Desiree Byrd, Susan Morgello, Matilde Inglese
BACKGROUND AND PURPOSE: In this pilot study, we sought to investigate the pathological changes in the white matter (WM) of medically complex, combination antiretroviral therapy (cART)-treated patients with human immunodeficiency virus (HIV), comparing them to patients with long-standing, secondary progressive multiple sclerosis (SPMS). METHODS: Using diffusion kurtosis imaging (DKI)-derived WM tract integrity (WMTI) metrics, 15 HIV and 15 age- and sex-matched SPMS patients with similar disease duration underwent magnetic resonance imaging analysis...
January 30, 2018: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/29378223/principles-of-diffusion-kurtosis-imaging-and-its-role-in-early-diagnosis-of-neurodegenerative-disorders
#19
REVIEW
Anas Arab, Anna Wojna-Pelczar, Amit Khairnar, Nikoletta Szabó, Jana Ruda-Kucerova
Pathology of neurodegenerative diseases can be correlated with intra-neuronal as well as extracellular changes which lead to neuronal degeneration. The central nervous system (CNS) is a complex structure comprising of many biological barriers. These microstructural barriers might be affected by a variety of pathological processes. Specifically, changes in the brain tissue's microstructure affect the diffusion of water which can be assessed non-invasively by diffusion weighted (DW) magnetic resonance imaging (MRI) techniques...
January 31, 2018: Brain Research Bulletin
https://www.readbyqxmd.com/read/29370870/diffusion-kurtosis-imaging-allows-the-early-detection-and-longitudinal-follow-up-of-amyloid-%C3%AE-induced-pathology
#20
Jelle Praet, Nikolay V Manyakov, Leacky Muchene, Zhenhua Mai, Vasilis Terzopoulos, Steve de Backer, An Torremans, Pieter-Jan Guns, Tom Van De Casteele, Astrid Bottelbergs, Bianca Van Broeck, Jan Sijbers, Dirk Smeets, Ziv Shkedy, Luc Bijnens, Darrel J Pemberton, Mark E Schmidt, Annemie Van der Linden, Marleen Verhoye
BACKGROUND: Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia in the elderly population. In this study, we used the APP/PS1 transgenic mouse model to explore the feasibility of using diffusion kurtosis imaging (DKI) as a tool for the early detection of microstructural changes in the brain due to amyloid-β (Aβ) plaque deposition. METHODS: We longitudinally acquired DKI data of wild-type (WT) and APP/PS1 mice at 2, 4, 6 and 8 months of age, after which these mice were sacrificed for histological examination...
January 9, 2018: Alzheimer's Research & Therapy
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