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https://www.readbyqxmd.com/read/28090658/analysis-of-the-effects-of-noise-dwi-sampling-and-value-of-assumed-parameters-in-diffusion-mri-models
#1
Elizabeth B Hutchinson, Alexandru V Avram, M Okan Irfanoglu, C Guan Koay, Alan S Barnett, Michal E Komlosh, Evren Özarslan, Susan C Schwerin, Sharon L Juliano, Carlo Pierpaoli
PURPOSE: This study was a systematic evaluation across different and prominent diffusion MRI models to better understand the ways in which scalar metrics are influenced by experimental factors, including experimental design (diffusion-weighted imaging [DWI] sampling) and noise. METHODS: Four diffusion MRI models-diffusion tensor imaging (DTI), diffusion kurtosis imaging (DKI), mean apparent propagator MRI (MAP-MRI), and neurite orientation dispersion and density imaging (NODDI)-were evaluated by comparing maps and histogram values of the scalar metrics generated using DWI datasets obtained in fixed mouse brain with different noise levels and DWI sampling complexity...
January 16, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28054731/lung-adenocarcinoma-assessment-of-epidermal-growth-factor-receptor-mutation-status-based-on-extended-models-of-diffusion-weighted-image
#2
Mei Yuan, Xue-Hui Pu, Xiao-Quan Xu, Yu-Dong Zhang, Yan Zhong, Hai Li, Jiang-Fen Wu, Tong-Fu Yu
PURPOSE: To evaluate the diagnostic performance of extended models of diffusion-weighted (DW) imaging to help differentiate the epidermal growth factor receptor (EGFR) mutation status in stage IIIA-IV lung adenocarcinoma. MATERIALS AND METHODS: This retrospective study had institutional research board approval and was HIPAA compliant. Preoperative extended DW imaging including intravoxel incoherent motion (IVIM) and diffusional kurtosis imaging (DKI) 3 Tesla MRI were retrospectively evaluated in 53 patients with pathologically confirmed non-early stage (IIIA-IV) lung adenocarcinoma...
January 5, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28046847/su-g-iep1-05-diffusion-kurtosis-imaging-for-oropharyngeal-cancer-detection
#3
Y Ding, A Mohamed, J Ma, S Frank, J Wang, C Fuller
PURPOSE: Diffusion kurtosis imaging (DKI) is an emerging diffusion MRI technique in cancer diagnosis applications. The objective of this study is to compare DKI with conventional diffusion weighted imaging (DWI) for diagnosis of head and neck cancer. METHODS: Five male patients with histologically documented phase II/III squamous cell carcinoma of the oropharynx were included in this study. DKI (with 6 b-values of 0-2000 s/mm2) and conventional DWI data were acquired at a 3...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28026061/detection-of-smoke-induced-pulmonary-lesions-by-hyperpolarized-129-xe-diffusion-kurtosis-imaging-in-rat-models
#4
Weiwei Ruan, Jianping Zhong, Yu Guan, Yi Xia, Xiuchao Zhao, Yeqing Han, Xianping Sun, Shiyuan Liu, Chaohui Ye, Xin Zhou
PURPOSE: To demonstrate that hyperpolarized (HP) xenon diffusion kurtosis imaging (DKI) is able to detect smoke-induced pulmonary lesions in rat models. METHODS: Multi-b DKI with hyperpolarized xenon was used for the first time in five smoke-exposed rats and five healthy rats. Additionally, DKI with b values of up to 80 s/cm(2) were used in two healthy rats to probe the critical b value (a limit beyond which the DKI cannot describe the non-Gaussian diffusion). RESULTS: The mean apparent diffusion coefficient (Dapp ) and diffusion kurtosis (Kapp ) extracted by the DKI model revealed significant changes in the smoke-exposed rats compared with those in the control group (P = 0...
December 27, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28012424/white-matter-microstructure-and-volitional-motor-activity-in-schizophrenia-a-diffusion-kurtosis-imaging-study
#5
Lise Docx, Louise Emsell, Wim Van Hecke, Timo De Bondt, Paul M Parizel, Bernard Sabbe, Manuel Morrens
Avolition is a core feature of schizophrenia and may arise from altered brain connectivity. Here we used diffusion kurtosis imaging (DKI) to investigate the association between white matter (WM) microstructure and volitional motor activity. Multi-shell diffusion MRI and 24-h actigraphy data were obtained from 20 right-handed patients with schizophrenia and 16 right-handed age and gender matched healthy controls. We examined correlations between fractional anisotropy (FA), mean diffusivity (MD), mean kurtosis (MK), and motor activity level, as well as group differences in these measures...
October 15, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/27993865/simultaneous-determination-of-five-specific-and-sensitive-nephrotoxicity-biomarkers-in-serum-and-urine-samples-of-four-drug-induced-kidney-injury-models
#6
Liqiang Gu, Huiyan Shi, Ruowen Zhang, Zhe Wei, Kai-Shun Bi, Xiao-Hui Chen
In clinical diagnosis, serum creatinine (CR) was commonly used as the routine markers for the evaluation of kidney injury. To investigate the specific and sensitive nephrotoxicity biomarkers in different drug-induced kidney injury (DKI) models, receiver operating characteristic (ROC) analysis was applied in this study. The quantification data were acquired by the LC-MS determination. Histopathology results showed that different kinds of kidney injuries were observed in different DKI models (gentamycin, cisplatin, methotrexate and amphotericin B models), indicating the injuries might be caused by different mechanisms...
January 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/27989906/advanced-diffusion-models-in-head-and-neck-squamous-cell-carcinoma-patients-goodness-of-fit-relationships-among-diffusion-parameters-and-comparison-with-dynamic-contrast-enhanced-perfusion
#7
Noriyuki Fujima, Tomohiro Sakashita, Akihiro Homma, Yukie Shimizu, Atsushi Yoshida, Taisuke Harada, Khin Khin Tha, Kohsuke Kudo, Hiroki Shirato
PURPOSE: We assessed advanced fitting models of diffusion weighted imaging (DWI) in head/neck squamous cell carcinoma (HNSCC) patients to determine the best goodness of fit and correlations among diffusion parameters. We compared these results with those of dynamic contrast-enhanced (DCE) perfusion parameters. MATERIALS AND METHODS: We retrospectively evaluated 32 HNSCC patients (12 sinonasal, 20 pharynx/oral cavity). The DWI acquisition used single-shot spin-echo echo-planar imaging (EPI) with 12 b-values (0-2000)...
October 27, 2016: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/27931179/structural-and-functional-integrity-of-the-intraparietal-sulcus-in-moderate-and-severe-traumatic-brain-injury
#8
Chandler Sours, Prashant Raghavan, Alexandre Medina de Jesus, Steven R Roys, Li Jiang, Jiachen Zhuo, Rao P Gullapalli
Severe and Moderate TBI (sTBI) often results in long-term cognitive deficits such as reduced processing speed and attention. The intraparietal sulcus (IPS) is a neocortical structure that plays a crucial role in the deeply interrelated processes of multisensory processing and top down attention. Therefore, we hypothesized that disruptions in the functional and structural connections of the IPS may play a role in the development of such deficits. To examine these connections we used resting state fMRI (rsfMRI) and diffusion kurtosis imaging (DKI) in a cohort of 27 sTBI patients (29...
December 8, 2016: Journal of Neurotrauma
https://www.readbyqxmd.com/read/27929929/diffusion-kurtosis-imaging-study-of-rectal-adenocarcinoma-associated-with-histopathologic-prognostic-factors-preliminary-findings
#9
Lan Zhu, Zilai Pan, Qian Ma, Wenjie Yang, Hongyuan Shi, Caixia Fu, Xu Yan, Lianjun Du, Fuhua Yan, Huan Zhang
Purpose To determine the correlation between diffusion kurtosis imaging (DKI)-derived parameters and prognostic factors for rectal adenocarcinoma. Materials and Methods This study was approved by the local institute review board, and written informed consent was obtained from each patient. Data from 56 patients (median age, 59.5 years; age range, 31-86 years) with rectal adenocarcinoma between April 2014 and September 2015 were involved in this prospective study. DKI (b = 0, 700, 1400, and 2100 sec/mm(2)) and conventional diffusion-weighted imaging (b = 0, 1000 sec/mm(2)) were performed...
December 5, 2016: Radiology
https://www.readbyqxmd.com/read/27923670/early-and-progressive-microstructural-brain-changes-in-mice-overexpressing-human-%C3%AE-synuclein-detected-by-diffusion-kurtosis-imaging
#10
Amit Khairnar, Jana Ruda-Kucerova, Nikoletta Szabó, Eva Drazanova, Anas Arab, Birgit Hutter-Paier, Joerg Neddens, Peter Latta, Zenon Starcuk, Irena Rektorova
Diffusion kurtosis imaging (DKI) is sensitive in detecting α-Synuclein (α-Syn) accumulation-associated microstructural changes at late stages of the pathology in α-Syn overexpressing TNWT-61 mice. The aim of this study was to perform DKI in young TNWT-61 mice when α-Syn starts to accumulate and to compare the imaging results with an analysis of motor and memory impairment and α-Syn levels. Three-month-old (3mo) and six-month-old (6mo) mice underwent DKI scanning using the Bruker Avance 9.4T magnetic resonance imaging system...
December 5, 2016: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/27866239/diffusion-kurtosis-imaging-and-diffusion-weighted-imaging-in-assessment-of-liver-fibrosis-stage-and-necroinflammatory-activity
#11
Ruo Fan Sheng, He Qing Wang, Li Yang, Kai Pu Jin, Yan Hong Xie, Cai Zhong Chen, Meng Su Zeng
PURPOSE: To investigate and compare the diagnostic value of diffusion kurtosis imaging (DKI) with diffusion-weighted imaging (DWI) in assessing and quantifying hepatic fibrosis. METHODS: Thirty rats were divided into the control group (n = 6) and the fibrosis experimental groups (n = 6 per group) with CCl4 administration for 2, 4, 6, and 8 weeks. Liver fibrosis stage (S) and necroinflammatory activity grade (G) were histopathologically determined. DKI and DWI were performed; mean apparent diffusion (MD), mean kurtosis (MK), and apparent diffusion coefficient (ADC) values were calculated...
November 19, 2016: Abdominal Radiology
https://www.readbyqxmd.com/read/27834215/diffusion-weighted-imaging-uncovers-likely-sources-of-processing-speed-deficits-in-schizophrenia
#12
Peter Kochunov, Laura M Rowland, Els Fieremans, Jelle Veraart, Neda Jahanshad, George Eskandar, Xiaoming Du, Florian Muellerklein, Anya Savransky, Dinesh Shukla, Hemalatha Sampath, Paul M Thompson, L Elliot Hong
Schizophrenia, a devastating psychiatric illness with onset in the late teens to early 20s, is thought to involve disrupted brain connectivity. Functional and structural disconnections of cortical networks may underlie various cognitive deficits, including a substantial reduction in the speed of information processing in schizophrenia patients compared with controls. Myelinated white matter supports the speed of electrical signal transmission in the brain. To examine possible neuroanatomical sources of cognitive deficits, we used a comprehensive diffusion-weighted imaging (DWI) protocol and characterized the white matter diffusion signals using diffusion kurtosis imaging (DKI) and permeability-diffusivity imaging (PDI) in patients (n = 74), their nonill siblings (n = 41), and healthy controls (n = 113)...
November 22, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27825037/evaluation-of-histopathological-changes-in-the-microstructure-at-the-center-and-periphery-of-glioma-tumors-using-diffusional-kurtosis-imaging
#13
Fuyan Li, Wenqi Shi, Dawei Wang, Yanjie Xu, Hongxia Li, Jingzhen He, Qingshi Zeng
OBJECTIVE: To explore the relationship between alterations in gliomas revealed by diffusional kurtosis imaging (DKI) and the histopathological microstructural changes. METHODS: Thirty-seven patients with cerebral gliomas underwent conventional MRI and DKI at 3.0T. Normalized fractional anisotropy (FA), mean diffusivity (MD) and mean kurtosis (MK) were compared in different regions of glioma tumors. Parameters with a high sensitivity and specificity regarding the discrimination of glioma grade were evaluated using receiver operating characteristic (ROC) curve analysis...
October 27, 2016: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/27796448/assessment-of-tissue-heterogeneity-using-diffusion-tensor-and-diffusion-kurtosis-imaging-for-grading-gliomas
#14
Rajikha Raja, Neelam Sinha, Jitender Saini, Anita Mahadevan, Kvl Narasinga Rao, Aarthi Swaminathan
INTRODUCTION: In this work, we aim to assess the significance of diffusion tensor imaging (DTI) and diffusion kurtosis imaging (DKI) parameters in grading gliomas. METHODS: Retrospective studies were performed on 53 subjects with gliomas belonging to WHO grade II (n = 19), grade III (n = 20) and grade IV (n = 14). Expert marked regions of interest (ROIs) covering the tumour on T2-weighted images. Statistical texture measures such as entropy and busyness calculated over ROIs on diffusion parametric maps were used to assess the tumour heterogeneity...
December 2016: Neuroradiology
https://www.readbyqxmd.com/read/27784203/repetitive-model-of-mild-traumatic-brain-injury-produces-cortical-abnormalities-detectable-by-magnetic-resonance-diffusion-imaging-dti-dki-histopathology-and-behavior
#15
Fengshan Yu, Dinesh K Shukla, Regina C Armstrong, Christina M Marion, Kryslaine L Radomski, Reed G Selwyn, Bernard J Dardzinski
Noninvasive detection of mild traumatic brain injury (mTBI) is important for evaluating acute through chronic effects of head injuries, particularly after repetitive impacts. To better detect abnormalities from mTBI, we performed longitudinal studies (baseline, 3, 6, and 42 days) using magnetic resonance diffusion tensor imaging (DTI) and diffusion kurtosis imaging (DKI) in adult mice after repetitive mTBI (r-mTBI; daily × 5) or sham procedure. This r-mTBI produced righting reflex delay and was first characterized in the corpus callosum to demonstrate low levels of axon damage, astrogliosis, and microglial activation, without microhemorrhages...
December 20, 2016: Journal of Neurotrauma
https://www.readbyqxmd.com/read/27769116/structure-reactivity-effects-on-intrinsic-primary-kinetic-isotope-effects-for-hydride-transfer-catalyzed-by-glycerol-3-phosphate-dehydrogenase
#16
Archie C Reyes, Tina L Amyes, John P Richard
Primary deuterium kinetic isotope effects (1°DKIE) on (kcat/KGA, M(-1) s(-1)) for dianion (X(2-)) activated hydride transfer from NADL to glycolaldehyde (GA) catalyzed by glycerol-3-phosphate dehydrogenase were determined over a 2100-fold range of enzyme reactivity: (X(2-), 1°DKIE); FPO3(2-), 2.8 ± 0.1; HPO3(2-), 2.5 ± 0.1; SO4(2-), 2.8 ± 0.2; HOPO3(2-), 2.5 ± 0.1; S2O3(2-), 2.9 ± 0.1; unactivated; 2.4 ± 0.2. Similar 1°DKIEs were determined for kcat. The observed 1°DKIEs are essentially independent of changes in enzyme reactivity with changing dianion activator...
November 9, 2016: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/27758016/diffusion-kurtosis-imaging-for-differentiating-between-the-benign-and-malignant-sinonasal-lesions
#17
Jing Xuan Jiang, Zuo Hua Tang, Yu Feng Zhong, Jin Wei Qiang
PURPOSE: The study aimed to evaluate diffusion kurtosis imaging (DKI) in the differentiation between benign and malignant sinonasal lesions, and to compare the diagnostic performance of DKI with diffusion weighted imaging (DWI). MATERIALS AND METHODS: Eight-one patients with solid sinonasal lesions confirmed by surgery and pathology (46 malignant and 35 benign) underwent conventional MRI, DWI, and DKI. DKI was performed employing a 13 extended b-value ranging from 0 to 2500 s/mm(2) ...
October 19, 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27731906/fast-diffusion-kurtosis-imaging-of-fibrotic-mouse-kidneys
#18
B F Kjølby, A R Khan, A Chuhutin, L Pedersen, J B Jensen, S Jakobsen, D Zeidler, R Sangill, J R Nyengaard, S N Jespersen, B Hansen
Diffusion kurtosis imaging (DKI) is sensitive to tissue microstructure and may therefore be useful in the diagnosis and monitoring of disease in brain and body organs. Generally, diffusion magnetic resonance imaging (dMRI) in the body is challenging because of the heterogeneous body composition, which can cause image artefacts as a result of chemical shifts and susceptibility differences. In addition, the abdomen possesses physiological factors (e.g. breathing, heartbeat, blood flow) which may severely reduce image quality, especially when echo planar imaging is employed, as is typical in dMRI...
December 2016: NMR in Biomedicine
https://www.readbyqxmd.com/read/27696558/fast-diffusion-kurtosis-imaging-dki-with-inherent-correlation-based-normalization-icon-enhances-automatic-segmentation-of-heterogeneous-diffusion-mri-lesion-in-acute-stroke
#19
Iris Yuwen Zhou, Yingkun Guo, Takahiro Igarashi, Yu Wang, Emiri Mandeville, Suk-Tak Chan, Lingyi Wen, Mark Vangel, Eng H Lo, Xunming Ji, Phillip Zhe Sun
Diffusion kurtosis imaging (DKI) has been shown to augment diffusion-weighted imaging (DWI) for the definition of irreversible ischemic injury. However, the complexity of cerebral structure/composition makes the kurtosis map heterogeneous, limiting the specificity of kurtosis hyperintensity to acute ischemia. We propose an Inherent COrrelation-based Normalization (ICON) analysis to suppress the intrinsic kurtosis heterogeneity for improved characterization of heterogeneous ischemic tissue injury. Fast DKI and relaxation measurements were performed on normal (n = 10) and stroke rats following middle cerebral artery occlusion (MCAO) (n = 20)...
December 2016: NMR in Biomedicine
https://www.readbyqxmd.com/read/27693403/imaging-the-transformation-of-ipsilateral-internal-capsule-following-focal-cerebral-ischemia-in-rat-by-diffusion-kurtosis-imaging
#20
Xiao-Xue Zhang, Le-Kang Yin, Xiao-Zhu Hao, Jia-Qi Tian, Chan-Chan Li, Xiao-Yuan Feng, Yan-Mei Yang
BACKGROUND: The purpose of our study is to explore the relationship between recovery of neural function and transformation of the internal capsule (IC) after transient middle cerebral artery occlusion (MCAO) by using diffusion kurtosis imaging (DKI). METHODS: Six male adult Sprague-Dawley rats implemented with transient MCAO were used in this study. Sensorimotor function was assessed according to repetitive behavioral testing on day 1, 3, 7, 14, and 28 after cerebral ischemia...
January 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
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