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https://www.readbyqxmd.com/read/29667889/journal-club-the-warthin-tumor-score-a-simple-and-reliable-method-to-distinguish-warthin-tumors-from-pleomorphic-adenomas-and-carcinomas
#1
Chih-Wei Wang, Yueng-Hsiang Chu, Deng-Yiv Chiu, Nieh Shin, Hsian-He Hsu, Jih-Chin Lee, Chun-Jung Juan
OBJECTIVE: The objective of this article is to propose a Warthin tumor (WT) score to distinguish WTs from other parotid tumors. MATERIALS AND METHODS: The study included 78 patients with 92 histologically proven parotid tumors, including 42 WTs, 30 pleomorphic adenomas (PMAs), and 20 carcinomas. Echo-planar DW images were acquired. The WT score, which comprised the mean apparent diffusion coefficient (ADCM ) and the SD of the ADC (ADCSD ) of tumors, patient age, and patient sex, was used to predict WTs...
April 18, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29667881/the-ability-of-adc-measurements-in-the-assessment-of-patients-with-stage-i-endometrial-carcinoma-based-on-three-risk-categories
#2
Shijia Wang, Jia Liu, Feng Yuan, Xiaojun Chen, Fenghua Ma, Guofu Zhang, Xiaomei Tian
Background Better selection of patients with intermediate and high-risk stage I endometrial carcinoma (EC) for lymphadenectomy has an important effect on the prognosis. Purpose To investigate the role of apparent diffusion coefficient (ADC) measurements in the assessment of stage I EC patients based on three risk categories. Material and Methods We retrospectively studied 80 patients with EC and 28 cervical cancer patients with normal endometrium. 1.5-T conventional magnetic resonance imaging (MRI) and diffusion-weighted imaging (DWI) (b = 0, 1000 s/mm2 ) were performed, and ADC values were calculated...
January 1, 2018: Acta Radiologica
https://www.readbyqxmd.com/read/29667827/in-situ-x-ray-diffraction-study-of-the-thermal-decomposition-of-selenogallates-cs-2-ga-2-se-2-2-x-se-2-x-x-0-1-2
#3
Daniel Friedrich, Marc Schlosser, Christian Näther, Arno Pfitzner
The selenogallates CsGaSe3 and Cs2 Ga2 Se5 release gaseous selenium upon heating. An in situ high-temperature X-ray powder diffraction analysis revealed a two-step degradation process from CsGaSe3 to Cs2 Ga2 Se5 and finally to CsGaSe2 . During each step, one Se2 2- unit of the anionic chains in Cs2 [Ga2 (Se2 )2- x Se2+ x ] ( x = 0, 1, 2) decomposes, and one equivalent of selenium is released. This thermal decomposition can be reverted by simple addition of elemental selenium and subsequent annealing of the samples below the decomposition temperature...
April 18, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29667690/metal-organic-frameworks-as-affinity-agents-to-enhance-the-microdialysis-sampling-efficiency-of-fatty-acids
#4
Hui Yang, Tuo Li, Lu Liu, Na Li, Ming Guan, Yangyang Zhang, Zhenpeng Wang, Zhenwen Zhao
Microdialysis (MD) has been extensively used for in vivo sampling of hydrophilic analytes such as neurotransmitters and drug metabolites. In contrast, there have been few reports on sampling of lipophilic analytes by MD. Lipophilic analytes are easily adsorbed on the surfaces of the dialysis membrane and the inner wall of tubing, which leads to a very low relative recovery (RR). In this work, a strategy to develop an enhanced MD sampling of fatty acids (FAs) by using metal-organic frameworks (MOFs) as affinity agents in the perfusion fluid was investigated...
April 18, 2018: Analyst
https://www.readbyqxmd.com/read/29667686/rheological-characterization-of-dynamic-remodeling-of-the-pericellular-region-by-human-mesenchymal-stem-cell-secreted-enzymes-in-well-defined-synthetic-hydrogel-scaffolds
#5
Maryam Daviran, Sarah M Longwill, Jonah F Casella, Kelly M Schultz
Human mesenchymal stem cells (hMSCs) dynamically remodel their microenvironment during basic processes, such as migration and differentiation. Migration requires extracellular matrix invasion, necessitating dynamic cell-material interactions. Understanding these interactions is critical to advancing materials designs that harness and manipulate these processes for applications including wound healing and tissue regeneration. In this work, we encapsulate hMSCs in a cell-degradable poly(ethylene glycol)-peptide hydrogel to determine how cell-secreted enzymes, specifically matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs), create unique pericellular microenvironments...
April 18, 2018: Soft Matter
https://www.readbyqxmd.com/read/29667605/hierarchical-layered-double-hydroxides-with-ag-nanoparticles-modification-for-ethanol-sensing
#6
Yuxiang Qin, Liping Wang, Xiaofei Wang
Layered double hydroxides (LDHs) are recently revealed to be promising in gas sensor application due to compositional flexibility and unique 2D-interlayer channel for gas diffusion and adsorption. This work demonstrates a kind of highly porous hierarchical LDHs containing Mg2+ and Al3+ (MgAl-LDHs) for ethanol-sensing at room temperature. The MgAl-LDHs with unique flower-like hierarchical structure and mesoporous interlayer were synthesized hydrothermally using sodium dodecyl sulfate (SDS) as soft template as well as intercalating agent...
April 18, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29667580/severe-asthma-phenotypes-classified-by-site-of-airway-involvement-and-remodeling-via-chest-ct-scan
#7
S Kim, K Nam Jin, S H Cho, C Hyun Lee, H R Kang
BACKGROUND AND OBJECTIVE: This study aimed to establish a system that can classify severe asthma on the basis of airway remodeling patterns visualized by computed tomography (CT) images and to evaluate the clinical characteristics of individual image-based subtypes. METHODS: Chest CT images of severe asthma patients were retrospectively evaluated to classify phenotypes by site of airway involvement and remodeling. The association between radiologic subtypes and clinical characteristics was assessed...
April 18, 2018: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/29667536/simulation-of-protein-diffusion-a-sensitive-probe-of-protein-solvent-interactions
#8
Valerio Ferrario, Jürgen Pleiss
Aqueous solutions of Candida antarctica lipase B (CALB) were simulated considering three different water models (SPC/E, TIP3P, TIP4P) by a series of molecular dynamics (MD) simulations of three different box sizes (L = 9, 14, and 19 nm) to determine the diffusion coefficient, the water viscosity, and the protein density. The protein-water systems were equilibrated for 500 ns, followed by 100 ns production runs which were analyzed. The diffusional properties of CALB were characterized by the Stokes radius (RS ), which was derived from the diffusion coefficient and the viscosity...
April 18, 2018: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/29667533/the-use-of-metal-hydroxide-sludge-in-natura-and-calcined-for-the-adsorption-of-brilliant-blue-dye-in-aqueous-solution
#9
Ana Maria Salgueiro Baptisttella, Andressa Aziz Diniz Araújo, Matheus Caldas Barreto, Vivian Stumpf Madeira, Mauricio Alves da Motta Sobrinho
Industrial waste such as metal hydroxide sludge (in natura and calcined) from galvanic bath was evaluated as an adsorbent in the removal of brilliant blue synthetic dye (NB 180) in aqueous solution. The samples were characterised using X-ray fluorescence analysis (XRF), X-ray diffraction analysis (XRD), thermogravimetric analysis (TGA), infrared spectroscopy (FT - IR), as well as the specific surface area (BET) and the point of zero charge (pHZCP ). The effects of the conditions in relation to pH and adsorbent dosage were also investigated...
April 18, 2018: Environmental Technology
https://www.readbyqxmd.com/read/29667510/air-quality-modeling-for-effective-environmental-management-in-the-mining-region
#10
Zunaira Asif, Zhi Chen, Yi Han
Air quality in the mining sector is a serious environmental concern and associated with many health issues. The air quality management in mining region has been facing many challenges due to lack of understanding of atmospheric factors and physical removal mechanism. A modeling approach called mining air dispersion model (MADM) is developed to predict air pollutants concentration in the mining region while considering the deposition effect. The model is taken into account through the planet's boundary conditions and assuming that the eddy diffusivity depends on the downwind distance...
April 18, 2018: Journal of the Air & Waste Management Association
https://www.readbyqxmd.com/read/29667317/relationships-between-executive-function-working-memory-and-decision-making-on-the-iowa-gambling-task-evidence-from-ventromedial-patients-dorsolateral-patients-and-normal-subjects
#11
Riadh Ouerchefani, Naoufel Ouerchefani, Philippe Allain, Mohamed Riadh Ben Rejeb, Didier Le Gall
The results of previous studies are inconsistent in regard to the relationship between the Iowa Gambling Task (IGT), working-memory (WM), and executive tasks, and whether these cognitive processes could be considered as mechanisms underlying a decision-making deficit. Moreover, the relationship between the IGT and executive measures is examined based on a limited number of executive tasks, within different populations showing diffuse damage. In addition, there are fewer studies carried out within control participants, with those studies also being inconclusive...
April 17, 2018: Journal of Neuropsychology
https://www.readbyqxmd.com/read/29667305/insight-into-ca-substitution-effects-on-o3-type-nani-1-3-fe-1-3-mn-1-3-o-2-cathode-materials-for-sodium-ion-batteries-application
#12
Liqi Sun, Yingying Xie, Xiao-Zhen Liao, Hong Wang, Guoqiang Tan, Zonghai Chen, Yang Ren, Jihyeon Gim, Wan Tang, Yu-Shi He, Khalil Amine, Zi-Feng Ma
O3-type NaNi1/3 Fe1/3 Mn1/3 O2 (NaNFM) is well investigated as a promising cathode material for sodium-ion batteries (SIBs), but the cycling stability of NaNFM still needs to be improved by using novel electrolytes or optimizing their structure with the substitution of different elements sites. To enlarge the alkali-layer distance inside the layer structure of NaNFM may benefit Na+ diffusion. Herein, the effect of Ca-substitution is reported in Na sites on the structural and electrochemical properties of Na1- x Cax /2 NFM (x = 0, 0...
April 18, 2018: Small
https://www.readbyqxmd.com/read/29667266/application-of-the-dawn-clinical-imaging-mismatch-and-defuse-3-selection-criteria-benefit-seems-similar-but-restrictive-volume-cut-offs-might-omit-potential-responders
#13
Célina Ducroux, Naim Khoury, Augustin Lecler, Raphaël Blanc, Annaëlle Chetrit, Hocine Redjem, Gabriele Ciccio, Stanislas Smajda, Simon Escalard, Jean-Philippe Desilles, Mikaël Mazighi, Malek Ben Maacha, Michel Piotin, Robert Fahed
BACKGROUND: We aimed to conduct an external validation of the selection criteria of the diffusion-weighted-imaging or computerized-tomography-perfusion assessment with clinical mismatch in the triage of wake-up and late-presenting strokes undergoing Neurointervention with Trevo (DAWN) and the Endovascular Therapy Following Imaging Evaluation for Ischemic Stroke (DEFUSE3) trials in a cohort of unknown onset stroke (UOS) patients treated with thrombectomy. METHODS: A validation cohort of UOS patients was selected from a prospectively collected thrombectomy database to match the inclusion criteria of DAWN and DEFUSE3...
April 18, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29667228/the-anterior-longitudinal-ligament-in-diffuse-idiopathic-skeletal-hyperostosis-ossified-or-displaced
#14
Jonneke S Kuperus, Esther Jm Smit, Behdad Pouran, Robbert W van Hamersvelt, Marijn van Stralen, Peter R Seevinck, Constantinus F Buckens, Ronald Law Bleys, Harrie H Weinans, F Cumhur Oner, Pim A de Jong, Jorrit-Jan Verlaan
Diffuse idiopathic skeletal hyperostosis (DISH) is often theorized to be an ossification of the anterior longitudinal ligament (ALL). Using computed tomography (CT) imaging and cryomacrotome sectioning we investigated the spatial relationship between the ALL and newly formed bone in DISH to test this hypothesis. In the current study, four human cadaveric spines diagnosed with DISH using CT imaging were frozen and sectioned using a cryomacrotome. Photographs were obtained of the specimen at 125µm intervals...
April 17, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29667201/functioning-of-potassium-and-magnesium-in-photosynthesis-photosynthate-translocation-and-photoprotection
#15
Merle Tränkner, Ershad Tavakol, Bálint Jákli
Potassium (K) and magnesium (Mg) are mineral nutrients that are required in large quantities by plants. Both elements critically contribute to the process of photosynthesis and the subsequent long-distance transport of photoassimilates. If K or Mg are not present in sufficient quantities in photosynthetic tissues, complex interactions of anatomical, physiological and biochemical responses result in a reduction of photosynthetic carbon assimilation. As a consequence, excessive production of reactive oxygen species causes photooxidation of the photosynthetic apparatus and cause an up-regulation of photoprotective mechanisms...
April 18, 2018: Physiologia Plantarum
https://www.readbyqxmd.com/read/29667176/pre-diagnostic-blood-immune-markers-incidence-and-progression-of-b-cell-lymphoma-and-multiple-myeloma-univariate-and-functionally-informed-multivariate-analyses
#16
Roel Vermeulen, Fatemeh Saberi Hosnijeh, Barbara Bodinier, Lützen Portengen, Benoît Liquet, Javiera Garrido-Manriquez, Henk Lokhorst, Ingvar A Bergdahl, Soterios A Kyrtopoulos, Ann-Sofie Johansson, Panagiotis Georgiadis, Beatrice Melin, Domenico Palli, Vittorio Krogh, Salvatore Panico, Carlotta Sacerdote, Rosario Tumino, Paolo Vineis, Raphaële Castagné, Marc Chadeau-Hyam
Recent prospective studies have shown that dysregulation of the immune system may precede the development of B-cell lymphomas (BCL) in immunocompetent individuals. However, to date, the studies were restricted to a few immune markers, which were considered separately. Using a nested case-control study within two European prospective cohorts, we measured plasma levels of 28 immune markers in samples collected a median of 6 years prior to diagnosis (range, 2.01-15.97) in 268 incident cases of BCL (including multiple myeloma) and matched controls...
April 18, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29667143/diagnostic-performance-of-18-f-fdg-pet-ct-and-whole-body-diffusion-weighted-imaging-with-background-body-suppression-dwibs-in-detection-of-lymph-node-and-bone-metastases-from-pediatric-neuroblastoma
#17
Hiroaki Ishiguchi, Shinji Ito, Katsuhiko Kato, Yusuke Sakurai, Hisashi Kawai, Naotoshi Fujita, Shinji Abe, Atsushi Narita, Nobuhiro Nishio, Hideki Muramatsu, Yoshiyuki Takahashi, Shinji Naganawa
OBJECTIVE: Recent many studies have shown that whole body "diffusion-weighted imaging with background body signal suppression" (DWIBS) seems a beneficial tool having higher tumor detection sensitivity without ionizing radiation exposure for pediatric tumors. In this study, we evaluated the diagnostic performance of whole body DWIBS and 18 F-FDG PET/CT for detecting lymph node and bone metastases in pediatric patients with neuroblastoma. METHODS: Subjects in this retrospective study comprised 13 consecutive pediatric patients with neuroblastoma (7 males, 6 females; mean age, 2...
April 17, 2018: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/29667086/contrast-enhancement-predicting-survival-in-integrated-molecular-subtypes-of-diffuse-glioma-an-observational-cohort-study
#18
Johann-Martin Hempel, Cornelia Brendle, Benjamin Bender, Georg Bier, Marco Skardelly, Irina Gepfner-Tuma, Franziska Eckert, Ulrike Ernemann, Jens Schittenhelm
INTRODUCTION: To assess the predictive value of magnetic resonance imaging (MRI) gadolinium enhancement as a prognostic factor in the 2016 World Health Organization Classification of Tumors of the Central Nervous System integrated glioma groups. METHODS: Four-hundred fifty patients with histopathologically confirmed glioma were retrospectively assessed between 07/1997 and 06/2014 using gadolinium enhancement, survival, and relevant prognostic molecular data [isocitrate dehydrogenase (IDH); alpha-thalassemia/mental retardation syndrome X-linked (ATRX); chromosome 1p/19q loss of heterozygosity; and O6-methylguanine DNA methyltransferase (MGMT)]...
April 17, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29667043/abnormalities-in-thalamo-cortical-connections-in-patients-with-first-episode-schizophrenia-a-two-tensor-tractography-study
#19
Hesham M Hamoda, A T Makhlouf, J Fitzsimmons, Y Rathi, N Makris, R I Mesholam-Gately, J D Wojcik, J Goldstein, R W McCarley, L J Seidman, M Kubicki, M E Shenton
The "cognitive dysmetria" hypothesis suggests that impairments in cognition and behavior in patients with schizophrenia can be explained by disruptions in the cortico-cerebellar-thalamic-cortical circuit. In this study we examine thalamo-cortical connections in patients with first-episode schizophrenia (FESZ). White matter pathways are investigated that connect the thalamus with three frontal cortex regions including the anterior cingulate cortex (ACC), ventrolateral prefrontal cortex (VLPFC), and lateral oribitofrontal cortex (LOFC)...
April 17, 2018: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/29666984/unusual-white-matter-involvement-in-east-syndrome-associated-with-novel-kcnj10-mutations
#20
Mariasavina Severino, Susanna Lualdi, Chiara Fiorillo, Pasquale Striano, Teresa De Toni, Silvio Peluso, Giuseppe De Michele, Andrea Rossi, Mirella Filocamo, Claudio Bruno
BACKGROUND: Epilepsy, ataxia, sensorineural deafness, and tubulopathy (EAST syndrome) is a rare channelopathy due to KCNJ10 mutations. So far, only mild cerebellar hypoplasia and/or dentate nuclei abnormalities have been reported as major neuroimaging findings in these patients. METHODS: We analyzed the clinical and brain MRI features of two unrelated patients (aged 27 and 23 years) with EAST syndrome carrying novel homozygous frameshift mutations (p.Asn232Glnfs*14and p...
April 17, 2018: Journal of Neurology
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