Davide Pintus, Maria G Cancedda, Giantonella Puggioni, Rosario Scivoli, Angela M Rocchigiani, Caterina Maestrale, Elisabetta Coradduzza, Roberto Bechere, Luciana Silva-Flannery, Hannah A Bullock, Simona Macciocu, Maria A Montesu, Vincenzo Marras, Simone Dore, Jana M Ritter, Ciriaco Ligios
ORF virus (ORFV) causes contagious ecthyma ("ORF"), a disease of sheep and goats characterized by lesions ranging from vesicles and pustules to atypical papilloma-like and angiomatous lesions in the skin and mucosae. The authors investigated the molecular factors leading to the ORF-associated atypical tumor-like changes. Fifteen lambs, 15 kids, and an adult ram clinically affected by natural ORFV infection were enrolled in the study and examined by several methods. ORFV was detected by viral culture or real-time polymerase chain reaction (RT-PCR) in the lesioned tissues and in the blood of the clinically affected sheep and goats...
April 13, 2024: Veterinary Pathology