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https://www.readbyqxmd.com/read/28454377/frequent-expression-of-human-leukocyte-antigen-class-i-and-the-status-of-intratumoral-immune-cells-in-alveolar-soft-part-sarcoma
#1
Akira Ogose, Hiroyuki Kawashima, Tetsuo Hotta, Takashi Ariizumi, Tetsuro Yamagishi, Naoki Oike, Taro Sasaki, Hiroshi Hatano, Hajime Umezu, Naoto Endo
The prognosis of alveolar soft part sarcoma is poor, despite the slow growth of the tumor. A number of cases with spontaneous regression of this rare tumor have been reported. Although the mechanisms underlying spontaneous regression remain uncertain, local immune reaction may be a possible contributing factor. Immunohistochemical expression of human leukocyte antigen (HLA) class I, cluster of differentiation (CD) 3, CD4, CD8, CD20, CD45, CD56, CD68, CD138 and CD163 were assessed in a series of 10 alveolar soft part sarcomas, and the expression profiles were associated with patients' clinicopathological parameters...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454064/withaferin-a-a-steroidal-lactone-encapsulated-mannose-decorated-liposomes-ameliorates-rheumatoid-arthritis-by-intriguing-the-macrophage-repolarization-in-adjuvant-induced-arthritic-rats
#2
Farhath Sultana, Manoj Kumar Neog, MahaboobKhan Rasool
In order to develop a better therapeutic approach for the treatment of rheumatoid arthritis (RA), withaferin-A; a steroidal lactone incorporated with mannosylated liposomes (ML-WA) was administered to adjuvant induced arthritic rats in intent to target the synovial macrophages. The confocal microscopy studies showed a successful internalization of ML-WA in the primarily isolated synovial macrophages. Consequently, targeting synovial macrophages via ML-WA reduced the oxidative stress (ROS and NO), and paw edema, however, a progressive gain in the body weight was observed in AIA rats...
April 23, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28444535/image-analysis-of-immune-cell-patterns-in-the-human-mammary-gland-during-the-menstrual-cycle-refines-lymphocytic-lobulitis
#3
Nadine S Schaadt, Juan Carlos López Alfonso, Ralf Schönmeyer, Anne Grote, Germain Forestier, Cédric Wemmert, Nicole Krönke, Mechthild Stoeckelhuber, Hans H Kreipe, Haralampos Hatzikirou, Friedrich Feuerhake
PURPOSE: To improve microscopic evaluation of immune cells relevant in breast cancer oncoimmunology, we aim at distinguishing normal infiltration patterns from lymphocytic lobulitis by advanced image analysis. We consider potential immune cell variations due to the menstrual cycle and oral contraceptives in non-neoplastic mammary gland tissue. METHODS: Lymphocyte and macrophage distributions were analyzed in the anatomical context of the resting mammary gland in immunohistochemically stained digital whole slide images obtained from 53 reduction mammoplasty specimens...
April 25, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28438619/implications-of-infiltrating-immune-cells-within-bone-marrow-of-patients-with-diffuse-large-b-cell-lymphoma
#4
Juhyeon Jeong, Eun Ji Oh, Woo Ick Yang, Soo Jeong Kim, Sun Och Yoon
The implications of infiltrating immune cells, especially T cells and macrophages, in the bone marrow (BM) microenvironment of patients with diffuse large B-cell lymphoma (DLBCL) have rarely been studied. We aimed to investigate the significance of infiltrating immune cells in the BM microenvironment as a prognostic factor for DLBCL patients. Using the initial pretreatment BM biopsy obtained from 198 DLBCL patients, we semiquantitatively evaluated CD3+ T cells, CD8+ T cells, and CD163+ macrophages that infiltrate into the paratrabecular and interstitial areas of BM by immunohistochemistry and analyzed their clinicopathological and prognostic implications...
April 21, 2017: Human Pathology
https://www.readbyqxmd.com/read/28438290/programmed-death-ligand-1-pd-l1-expression-and-tumor-microenvironment-implications-for-patients-with-oral-precancerous-lesions
#5
Takahiro Yagyuu, Kinta Hatakeyama, Mitsuhiko Imada, Miyako Kurihara, Yumiko Matsusue, Kazuhiko Yamamoto, Chiho Obayashi, Tadaaki Kirita
OBJECTIVES: Cancer immunoediting represents a relatively novel concept attempting to explain the process of tumor escape from the host immune system response. Here, we attempted to elucidate the role of programmed death ligand 1 (PD-L1), the tumor microenvironment, and tumor escape mechanisms that allow malignant transformation of oral precancerous lesions. MATERIALS AND METHODS: Patients with oral precancerous lesions managed at the Nara Medical University Hospital, Japan, (n=120) were enrolled in this study...
May 2017: Oral Oncology
https://www.readbyqxmd.com/read/28436576/the-role-of-macrophages-in-the-pathogenesis-of-mycosis-fungoides
#6
D Ö Kara, K Ç Özsaraç, M K Uzar, Ö Bozdoğan, Ö Gündüz
BACKGROUND: Macrophages are classified into classically activated (M1) and alternatively activated (M2) macrophages. Decrease in macrophage number in tumour tissue with treatment has been reported. AIM: The aim of this study was to determine whether treatment has an effect on the number of dermal M1 and M2 macrophages in patients with mycosis fungoides (MF). METHODS: In total, 21 patients (8 women, 13 men; age range 42-73 years) were included in this study...
April 24, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28435287/serum-galectin-1-in-patients-with-multiple-myeloma-associations-with-survival-angiogenesis-and-biomarkers-of-macrophage-activation
#7
Morten Nørgaard Andersen, Maja Ludvigsen, Niels Abildgaard, Irma Petruskevicius, Rikke Hjortebjerg, Mette Bjerre, Bent Honoré, Holger J Møller, Niels F Andersen
Galectin-1 (Gal-1) is known to regulate cell signaling within the immune system and may be a target for new anticancer immune therapy. In patients with chronic lymphocytic leukemia (CLL) and classical Hodgkin lymphoma (cHL), high levels of Gal-1 within the tumor microenvironment were associated with worse disease state or poor outcome. Gal-1 can be secreted from cells by an unknown mechanism, and levels in blood samples were associated with high tumor burden and worse disease state in cHL and CLL patients. However, serum levels of Gal-1 have never been investigated in patients with multiple myeloma (MM)...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28434701/upregulated-interleukins-il-6-il-10-and-il-13-in-immunoglobulin-g4-related-aortic-aneurysm-patients
#8
Satomi Kasashima, Atsuhiro Kawashima, Yoh Zen, Satoru Ozaki, Fuminori Kasashima, Masamitsu Endo, Yasushi Matsumoto, Kengo Kawakami
OBJECTIVE: Immunoglobulin (Ig) G4-related aortic aneurysms (IgG4-AAs) are a special aortic aneurysm among IgG4-related diseases (IgG4-RDs), which are inflammatory and fibrous conditions characterized by tumorous swelling of affected organs and high serum IgG4 concentrations. Recently, IgG4-RD pathogenesis was shown to be associated with T-helper-2 (Th2) and regulatory T (Treg) dominant cytokine production, such as interleukin (IL)-4, IL-10, and IL-13. IL-6 is a key proinflammatory cytokine contributing to lymphocyte and plasmacyte maturation and to atherosclerosis and aneurysm development...
April 20, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28432704/human-galectin-9-on-the-porcine-cells-affects-the-cytotoxic-activity-of-m1-differentiated-thp-1-cells-through-inducing-a-shift-in-m2-differentiated-thp-1-cells
#9
Sung Han Jung, Jeong Ho Hwang, Sang Eun Kim, Young Kyu Kim, Hyo Chang Park, Hoon Taek Lee
BACKGROUND: In xenotransplantation, immune rejection by macrophages occurs rapidly and remains a major obstacle. Studies to control immune rejection in macrophages have been continuing to date. Recent studies have reported that human galectin-9 (hGal-9) can regulate the function of regulatory T cells (Treg), as well as cytotoxicity T cells (CTL) and natural killer cells (NK). Although the effect of hGal-9 on lymphocytes has been well studied, the relationship between hGal-9 and myeloid cells has been scarcely studied...
April 21, 2017: Xenotransplantation
https://www.readbyqxmd.com/read/28432434/ventricular-androgenic-anabolic-steroid-related-remodeling-an-immunohistochemical-study
#10
Rossana Cecchi, Barbara Muciaccia, Costantino Ciallella, Natale Mario Di Luca, Akihiko Kimura, Cristina Sestili, Mizuho Nosaka, Toshikazu Kondo
BACKGROUND: Several fatal cases of bodybuilders, following a myocardial infarction after long exposure to androgenic-anabolic steroids (AAS), are reported. In recent years, evidence has emerged of cases of heart failure related to AAS consumption, with no signs of coronary or aorta atherosclerosis. This study aims to further investigate the pathogenesis of the ventricular AAS-related remodeling performing immunohistochemistry (IHC). METHOD: In order to examine innate immunity activity and myocytes and endothelial cell apoptosis, IHC analyses were performed on heart tissue of two cases of bodybuilders who died after years of supratherapeutic use of metelonone and nandrolone and where no atherosclerosis or thrombosis were found, using the following antibodies: anti-CD68, anti-iNOS, anti-CD163, anti-CD 15, anti-CD8, anti-CD4, anti-HIF1 α, and in situ TUNEL staining...
April 21, 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/28428887/differential-intratumoral-distributions-of-cd8-and-cd163-immune-cells-as-prognostic-biomarkers-in-breast-cancer
#11
Sotirios P Fortis, Michael Sofopoulos, Nectaria N Sotiriadou, Christoforos Haritos, Christoforos K Vaxevanis, Eleftheria A Anastasopoulou, Nicole Janssen, Niki Arnogiannaki, Alexandros Ardavanis, Graham Pawelec, Sonia A Perez, Constantin N Baxevanis
BACKGROUND: Tumor immune cell infiltrates are essential in hindering cancer progression and may complement the TNM classification. CD8+ and CD163+ cells have prognostic impact in breast cancer but their spatial heterogeneity has not been extensively explored in this type of cancer. Here, their potential as prognostic biomarkers was evaluated, depending on their combined densities in the tumor center (TC) and the tumor invasive margin (IM). METHODS: CD8+ and CD163+ cells were quantified by immunohistochemistry of formalin-fixed, paraffin-embedded (FFPE) tumor tissue samples from a cohort totaling 162 patients with histologically-confirmed primary invasive non-metastatic ductal breast cancer diagnosed between 2000 and 2015...
2017: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/28427165/prognostic-significance-of-tumor-associated-macrophages-in-breast-cancer-a-meta-analysis-of-the-literature
#12
REVIEW
Xixi Zhao, Jingkun Qu, Yuchen Sun, Jizhao Wang, Xu Liu, Feidi Wang, Hong Zhang, Wen Wang, Xingcong Ma, Xiaoyan Gao, Shuqun Zhang
PURPOSE: Tumor associated macrophages (TAMs) are important prognostic factors and have been proved to be associated with the invasion and migration of various cancer. However, the relationship between TAMs and breast cancer outcomes remains unclear. EXPERIMENTAL DESIGN: Sixteen studies with a total of 4,541 breast cancer patients were included in this meta-analysis. Correlation of TAMs with overall survival (OS), disease-free survival(DFS), relapse-free survival (RFS), breast cancer special survival (BCSS) and clinicopathological features were analyzed...
February 25, 2017: Oncotarget
https://www.readbyqxmd.com/read/28424285/equine-arteritis-virus-has-specific-tropism-for-stromal-cells-and-cd8-t-and-cd21-b-lymphocytes-but-not-glandular-epithelium-at-the-primary-site-of-persistent-infection-in-the-stallion-reproductive-tract
#13
Mariano Carossino, Alan T Loynachan, Igor F Canisso, R Frank Cook, Juliana R Campos, Bora Nam, Yun Young Go, Edward L Squires, Mats H T Troedsson, Thomas Swerczek, Fabio Del Piero, Ernest Bailey, Peter J Timoney, Udeni B R Balasuriya
Equine arteritis virus (EAV) has a global impact on the equine industry being the causative agent of equine viral arteritis (EVA), a respiratory, systemic, and reproductive disease of equids. A distinctive feature of EAV infection is that it establishes long-term persistent infection in 10 to 70% of infected stallions (carriers). In these stallions, EAV is only detectable in the reproductive tract and viral persistence occurs despite the presence of high serum neutralizing antibodies. Carrier stallions constitute the natural reservoir of the virus as they continuously shed EAV in their semen...
April 19, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28423526/cd163-as-a-marker-of-m2-macrophage-contribute-to-predicte-aggressiveness-and-prognosis-of-kazakh-esophageal-squamous-cell-carcinoma
#14
Jian Ming Hu, Kai Liu, Ji Hong Liu, Xian Li Jiang, Xue Li Wang, Yun Zhao Chen, Shu Gang Li, Hong Zou, Li Juan Pang, Chun Xia Liu, Xiao Bin Cui, Lan Yang, Jin Zhao, Xi Hua Shen, Jin Fang Jiang, Wei Hua Liang, Xiang Lin Yuan, Feng Li
M2 macrophages was domesticated by tumor microenvironment to produce some angiogenic molecules and protease, facilitating angiogenesis and matrix breakdown, promoting tumor invasive and metastasis. However, The function of M2 macrophages to progression of eophageal carcinoma, especially Kazakh esophageal carcinoma is still dimness. This study aims to investigate M2 macrophages correlated with matrix metalloproteinase-9 (MMP9) and microvessel density, and the role in the progression of Kazakh esophageal squamous cell carcinoma...
March 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28422875/jagged1-modulated-tumor-associated-macrophage-differentiation-predicts-poor-prognosis-in-patients-with-invasive-micropapillary-carcinoma-of-the-breast
#15
Hang Liu, Jingxuan Wang, Zhaoliang Liu, Le Wang, Shoujun Liu, Qingyuan Zhang
OBJECTIVES: Invasive micropapillary carcinoma of the breast (IMPC) constitutes a unique and aggressive subtype of breast cancer. We aimed to evaluate the prognostic significance of the Jagged1 (a ligand of the Notch pathway) expression, and infiltration density of tumor-associated macrophages (TAMs) in patients with IMPC. METHODS: Jagged1 expression and CD163+, CD68+ macrophage infiltration were evaluated by immunohistochemistry in 222 tumor samples, and the clinical significance was analyzed...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28422854/immunohistological-analysis-of-active-sacroiliitis-in-patients-with-axial-spondyloarthritis
#16
Jianhua Peng, Yao Gong, Yuping Zhang, Danmin Wang, Zhengyu Xiao
The sacroiliac joints (SIJs) are one of the most common sites involved in axial spondyloarthritis (axSpA), and there are few studies on the histopathology of the SIJ in this group of patients.Mononuclear cell infiltrates in the bone marrow and fibrous tissue resembling a pannus formation were the pathological features of early sacroiliitis in our previous study. We undertook a further immunohistological evaluation of these features in patients with axSpA.Biopsy specimens from the SIJ of 6 patients with established ankylosing spondylitis (AS) and 13 patients with nonradiographic axial spondyloarthritis (nr-axSpA) were analyzed...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28420398/mechanisms-of-corticosteroid-insensitivity-in-copd-alveolar-macrophages-exposed-to-nthi
#17
Rana M Khalaf, Simon R Lea, Hannah J Metcalfe, Dave Singh
BACKGROUND: Non-typeable Haemophilus influenza (NTHi) infection is common in COPD. Corticosteroids can have limited therapeutic effects in COPD patients. NTHi causes corticosteroid insensitive cytokine production from COPD alveolar macrophages. We investigated the mechanisms by which NTHi causes corticosteroid insensitive inflammatory responses, and the effects of NTHi exposure on COPD macrophage polarisation. METHOD: Alveolar macrophages from COPD patients and controls were exposed to NTHi in conjunction with the corticosteroid dexamethasone and/or the p38 MAPK inhibitor BIRB-796...
April 18, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28419539/pd-l1-expression-in-extrahepatic-cholangiocarcinoma
#18
Dirk Walter, Eva Herrmann, Andreas Schnitzbauer, Stefan Zeuzem, Martin Leo Hansmann, Jan Peveling-Oberhag, Sylvia Hartmann
AIMS: To investigate expression of programmed cell death 1 (PD-1) receptor / programmed cell death ligand 1 (PD-L1) pathway as well as clinicopathological characteristics in extrahepatic cholangiocarcinoma (eCCA). METHODS: Tissue samples from patients with eCCA (n=69; perihilar CCA=40, distal CCA=29), who underwent surgical resection in the period from 2007 to 2015 were evaluated for PD-1, PD-L1, CD3 and CD163 expression and correlation with clinicopathological characteristics, including survival data, was performed...
April 17, 2017: Histopathology
https://www.readbyqxmd.com/read/28419526/soluble-egg-antigen-activates-m2-macrophages-via-the-stat6-and-pi3k-pathways-and-schistosoma-japonicum-alternatively-activates-macrophage-polarization-to-improve-the-survival-rate-of-septic-mice
#19
Hao Tang, Yan-Bing Liang, Zhi-Bin Chen, Lin-Lin Du, Li-Jin Zeng, Jing-Guo Wu, Wen Yang, Hua-Ping Liang, Zhong-Fu Ma
Sepsis is one of the most challenging health problems worldwide. Our previous study showed that chronic schistosoma japonica (SJ) infection might increase serum anti-inflammatory factors to play a protective role, thus improving the survival rate of septic mice. Further research revealed that SJ infection promoted J774A.1 macrophage differentiation into M2 macrophages; suppressed LPS-induced activation of M1 macrophages; up-regulated CD163, IL-10 and TGF-β1 expression; inhibited TNF-α and iNOS expression; and blocked the effect of LPS-promoted TNF-α and iNOS expression...
April 17, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28419494/increased-levels-of-soluble-cd163-in-periodontitis-patients
#20
Laurent Detzen, Steven C Y Chen, Bin Cheng, Panos N Papapanou, Evanthia Lalla
AIM: Soluble CD163 (sCD163) has been implicated as a new biomarker in inflammatory conditions. The aim of this cross-sectional study was to assess CD163 levels systemically and locally in patients with chronic periodontitis. METHODS: sCD163 levels were measured by ELISA in serum samples from 70 periodontitis and 70 periodontally healthy subjects, and in saliva samples in a subset of the population. Two gingival biopsies were harvested per subject from 20 periodontitis patients: one from a periodontally affected site, the other from a healthy site, and the relative expression of CD163 mRNA was assessed by real-time PCR...
April 17, 2017: Journal of Clinical Periodontology
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