Read by QxMD icon Read


Paul J Guyett, Shuangluo Xia, David C Swinney, Michael P Pollastri, Kojo Mensa-Wilmot
Human parasite Trypanosoma brucei proliferates in the blood of its host, where it takes up iron via receptor-mediated endocytosis of transferrin (Tf). Mechanisms of Tf endocytosis in the trypanosome are not fully understood. Small molecule lapatinib inhibits Tf endocytosis in T. brucei and associates with protein kinase GSK3β (TbGSK3β). Therefore, we hypothesized that Tf endocytosis may be regulated by TbGSK3β, and we used three approaches (both genetic and small molecule) to test this possibility. First, the RNAi knock-down of TbGSK3β reduced Tf endocytosis selectively, without affecting the uptake of haptaglobin-hemoglobin (Hp-Hb) or bovine serum albumin (BSA)...
July 8, 2016: ACS Infectious Diseases
Vishnu Swarup, Achal K Srivastava, Moganty R Rajeswari
Spinocerebellar ataxia 12 (SCA12) is a unique dominant type of ataxia characterized by early and prominent action tremors, memory deficit, neuropathy, dysarthria, etc. The expansion of DNA triplet (CAG) repeats in 5'UTR of PPP2R2B gene appears to be the cause for the pathogenesis of the neurodegenerative disorder, SCA12. The objective of the current study was to identify the aberrantly expressed plasma proteins for their potential application in therapy or diagnosis/prognosis of SCA12. Sixty-two clinically suspected patients were assessed using International Co-operative Ataxia Rating Scale (ICARS) and genetic confirmation was done using PCR followed by DNA sequencing...
June 2012: Neuroscience Research
Fiona Crispie, Mercedes Alonso-Gómez, Collette O'Loughlin, Katja Klostermann, James Flynn, Seán Arkins, William Meaney, R Paul Ross, Colin Hill
In the accompanying article, we demonstrated that a live culture of Lactococcus lactis compares favourably with antibiotics for treatment of bovine mastitis in two initial field trials. In an effort to explain the mechanism involved, this study investigated the effect of culture administration on the local immune response. In this respect we initially observed that infusion of the live culture Lactococcus lactis stimulated substantial recruitment of polymorphonucleocytes (PMN) and lymphocytes to the udder. For instance, in one assay, quarters infused with the probiotic experienced a dramatic increase (approximately 20,000-fold) in neutrophils over the first 48-h period from an average value of 83...
August 2008: Journal of Dairy Research
Rajesh K Thimmulappa, Kim H Mai, Sorachai Srisuma, Thomas W Kensler, Masayuki Yamamoto, Shyam Biswal
Electrophiles formed during metabolic activation of chemical carcinogens and reactive oxygen species generated from endogenous and exogenous sources play a significant role in carcinogenesis. Cancer chemoprevention by induction of phase 2 proteins to counteract the insults of these reactive intermediates has gained considerable attention. Nuclear factor E2 p45-related factor 2 (Nrf2), a bZIP transcription factor, plays a central role in the regulation (basal and or inducible expression) of phase 2 genes by binding to the "antioxidant response element" in their promoters...
September 15, 2002: Cancer Research
H Uludag, M V Sefton
The feasibility of a microencapsulation process ultimately for cell transplantation was investigated by encapsulating human hepatoma (HepG2) cells in hydroxyethyl methacrylate-methyl methacrylate (HEMA-MMA) membranes through an interfacial precipitation process. Changes in viability and metabolic activity as well as protein secretion by the encapsulated cells were studied in vitro. When encapsulated at either low or high density (1 or 5 x 10(6) cells/mL, respectively), HepG2 cells retained their active metabolic state and/or proliferated during the initial 1-week period, after which a significant drop in cell viability was obtained...
October 1993: Journal of Biomedical Materials Research
J Lindner, V Skokanová
The submitted investigation deals with the value of assessment of selected reactants of the acute stage in patients with acute pancreatitis and their follow-up in the course of the disease. For the investigation C-reactive protein, alpha-1-antitrypsin and haptaglobin were selected. In addition to the prognostic impact the authors focused attention on assessment of the dynamics of individual proteins and their importance for the early detection of complications in acute pancreatitis with different etiologies...
February 1995: Rozhledy V Chirurgii: Měsíčník Československé Chirurgické Společnosti
M Szubiński, J Grzybowski, Z Górka
No abstract text is available yet for this article.
1967: Acta Physiologica Polonica
B Turowska, M Gurda
No abstract text is available yet for this article.
1967: Przegla̧d Lekarski
D Sedlácek, T Stuksová, K Novák, A Stajner
The more frequent incidence of infections after splenectomy, some leading even to OPSI syndrome, is known from the literature and practice. The authors investigated in two groups of 20 splenectomized patients (on account of injury of the spleen or for haematological reasons) in particular changes of immunological indicators. On both groups they revealed a predominating increase of the absolute number of leucocytes, lymphocytes, the phagocytic index of PMN leucocytes, the ratio of active nucleoli, FW. They found also in both groups a predominating reduction of the number of T lymphocytes (p less than 0...
July 21, 1989: Casopís Lékar̆ů C̆eských
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"