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Francesc Xavier Avilés-Jurado, Ximena Terra, David Gómez, Joan Carles Flores, Antoni Raventós, Elsa Maymó-Masip, Xavier León, Vicente Serrano-Gonzalvo, Joan Vendrell, Enric Figuerola, Matilde R Chacón
Identifying serum pre-treatment molecular markers that can predict response to therapy is of great interest in head and neck oncology and is required to develop personalized treatments that maximize survival while minimizing morbidity. The main aim was to investigate the potential prognostic significance of tumor necrosis factor-like weak inducer of apoptosis (TWEAK), and its receptors, fibroblast growth factor-inducible 14 (Fn14) and CD163, in head and neck squamous cell carcinoma (HNSCC). The study comprised 37 consecutive patients with pathologically confirmed, untreated HNSCC...
July 2015: European Archives of Oto-rhino-laryngology
Ying-Ying Yang, Ming-Chih Hou, Ming-Wei Lin, Ping-Hsien Chen, Wei-Chih Liao, Chi-Jen Chu, Han-Chieh Lin
BACKGROUND AND AIM: Endoscopic screening for esophageal varices (EVs) is expensive and invasive. Besides traditional noninvasive markers, we explore additional candidate markers including portal hypertension serum marker-soluble CD136 (sCD163) and genetic variants of splanchnic vasodilatation and revascularization pathways for prediction of EVs in cirrhotic patients. METHODS: A total of 951 cirrhotic patients without history of variceal bleeding and an independent validation cirrhotic cohort were enrolled to evaluate the association between the presence of EVs and patients' clinical and genetic characteristics...
January 2013: Journal of Gastroenterology and Hepatology
Jiqiu Wen, Jisong Chen, Shu-Ming Ji, Dongrui Cheng, Zhi-hong Liu
OBJECTIVE: To investigate the correlation between circulating endothelial cells (CECs) and vascular lesions in renal allografts. METHODOLOGY: Sixty-two renal transplant patients were divided into four groups according to biopsy data. CECs were isolated from peripheral blood with anti-CD136-coated immunomagnetic Dynabeads and counted by microscopy during biopsy. CEC numbers were compared in each group, as well as the correlation between CECs and C4d and vascular changes in different groups...
July 2012: Clinical Transplantation
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