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Spermatogonia stem cell

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https://www.readbyqxmd.com/read/29781095/gasoline-exhaust-damages-spermatogenesis-through-downregulating-%C3%AE-6-integrin-and-%C3%AE-1-integrin-in-the-rat-model
#1
L Luo, E Li, S Zhao, J Wang, Z Zhu, Y Liu, J Luo, Z Zhao
The health influence of air pollution has been an international public health concern. Increasing evidence has suggested that air pollution has been associated with decreased sperm quality. However, the underlying molecular mechanisms are still not fully elucidated. We aimed to verify whether gasoline exhaust leads to reproductive impairment by injuring spermatogonial stem cells and explore its underlying molecular mechanism. Twenty male Sprague-Dawley rats were randomly divided into two groups: the exposure group (n = 10) and the control group (n = 10)...
May 20, 2018: Andrologia
https://www.readbyqxmd.com/read/29772210/in-silico-analysis-seasonal-variation-and-gonadotropic-regulation-of-jag1-and-its-receptor-notch1-in-testis-of-spotted-snakehead-channa-punctatus
#2
Alivia Roy, Reetuparna Basak, Umesh Rai
The present study in seasonally breeding spotted snakehead Channa punctatus, for the first time in nonmammalian vertebrates, demonstrated correlation between reproductive phase-dependent testicular expression of ligand Jag1/receptor Notch1 and spermatogenic events. Testicular transcriptome sequencing data from our earlier study in C. punctatus was used in the present study to select the best transcript for jag1 (cpjag1) and notch1 (cpnotch1). The transcripts cpjag1 and cpnotch1 encoded full-length putative proteins of 1215 (cpJag1) and 2475 (cpNotch1) amino acids, respectively...
May 14, 2018: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29769589/conserved-and-non-conserved-characteristics-of-porcine-glial-cell-line-derived-neurotrophic-factor-expressed-in-the-testis
#3
Kazue Kakiuchi, Kazumi Taniguchi, Hiroshi Kubota
Glial cell line-derived neurotrophic factor (GDNF) is essential for the self-renewal and proliferation of spermatogonial stem cells (SSCs) in mice, rats, and rabbits. Although the key extrinsic factors essential for spermatogonial proliferation in other mammals have not been determined, GDNF is one of the potential candidates. In this study, we isolated porcine GDNF (pGDNF) cDNAs from neonatal testis and generated recombinant pGDNF to investigate its biological activity on gonocytes/undifferentiated spermatogonia, including SSCs...
May 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29763586/postnatal-testis-development-in-the-collared-peccary-tayassu-tajacu-with-emphasis-on-spermatogonial-stem-cells-markers-and-niche
#4
Nathália de Lima E Martins Lara, Guilherme Mattos Jardim Costa, Gleide Fernandes de Avelar, Diva Anelie Guimarães, Luiz Renato de França
Collared peccaries (Tayassu tajacu) present a unique testis cytoarchitecture, where Leydig cells (LC) are mainly located in cords around the seminiferous tubules (ST) lobes. This peculiar arrangement is very useful to better investigate and understand the role of LC in spermatogonial stem cells (SSCs) biology and niche. Recent studies from our laboratory using adult peccaries have shown that the undifferentiated type A spermatogonia (Aund or SSCs) are preferentially located in ST regions adjacent to the intertubular compartment without LC...
May 12, 2018: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29733421/chemotherapeutic-drugs-alter-functional-properties-and-proteome-of-mouse-testicular-germ-cells-in-vitro
#5
Polash Chandra Karmakar, Yeon-Jin Cho, Yong-Hee Kim, Sang-Eun Jung, Ju-Hee Jin, Bang-Jin Kim, Woo-Sung Kwon, Young-Hyun Kim, Myung-Geol Pang, Buom-Yong Ryu
Many of the testicular cancer-survived patients, treated with chemotherapeutic drugs, show infertility, preimplantation and postimplantation loss, and germ cell abnormality. Studies examining the negative effects of chemotherapeutic drugs on testicular germ cells are ongoing; however, information on the stemness properties and proteomic profiles of these cells are lacking. The present study investigated the effects of chemotherapeutic drugs etoposide, cisplatin, bleomycin, and their combination (BEP) on the physiology and stem cell activity of mouse germ cells in vitro...
April 27, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29730571/spermatogonial-stem-cells-and-spermatogenesis-in-mice-monkeys-and-men
#6
Adetunji P Fayomi, Kyle E Orwig
Continuous spermatogenesis in post-pubertal mammals is dependent on spermatogonial stem cells (SSCs), which balance self-renewing divisions that maintain stem cell pool with differentiating divisions that sustain continuous sperm production. Rodent stem and progenitor spermatogonia are described by their clonal arrangement in the seminiferous epithelium (e.g., Asingle , Apaired or Aaligned spermatogonia), molecular markers (e.g., ID4, GFRA1, PLZF, SALL4 and others) and most importantly by their biological potential to produce and maintain spermatogenesis when transplanted into recipient testes...
April 21, 2018: Stem Cell Research
https://www.readbyqxmd.com/read/29721205/treosulfan-induces-distinctive-gonadal-toxicity-compared-with-busulfan
#7
Mattan Levi, Salomon M Stemmer, Jerry Stein, Ruth Shalgi, Irit Ben-Aharon
Treosulfan (L-treitol-1,4-bis-methanesulfonate) has been increasingly incorporated as a main conditioning protocol for hematopoietic stem cell transplantation in pediatric malignant and non-malignant diseases. Treosulfan presents lower toxicity profile than other conventional alkylating agents containing myeloablative and immunosuppressive traits such as busulfan. Yet, whereas busulfan is considered highly gonadotoxic, the gonadal toxicity profile of treosulfan remains to be elucidated. To study the gonadotoxicity of treosulfan, pubertal and prepubertal male and female mice were injected with treosulfan or busulfan and sacrificed one week, one month or six months later...
April 10, 2018: Oncotarget
https://www.readbyqxmd.com/read/29683733/cep55-overexpression-causes-male-specific-sterility-in-mice-by-suppressing-foxo1-nuclear-retention-through-sustained-activation-of-pi3k-akt-signaling
#8
Debottam Sinha, Murugan Kalimutho, Josephine Bowles, Ai-Leen Chan, D Jo Merriner, Amanda L Bain, Jacinta L Simmons, Raimundo Freire, J Alejandro Lopez, Robin M Hobbs, Moira K O'Bryan, Kum Kum Khanna
Spermatogenesis is a dynamic process involving self-renewal and differentiation of spermatogonial stem cells, meiosis, and ultimately, the differentiation of haploid spermatids into sperm. Centrosomal protein (CEP)-55 is necessary for somatic cell abscission during cytokinesis. It facilitates equal segregation of cytoplasmic contents between daughter cells by recruiting endosomal sorting complex required for transport machinery (ESCRT) at the midbody. In germ cells, CEP55, in partnership with testes expressed-14 protein (TEX14), has also been shown to be an integral component of intercellular bridge before meiosis...
April 17, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29681540/fgf2-has-distinct-molecular-functions-from-gdnf-in-the-mouse-germline-niche
#9
Kaito Masaki, Mizuki Sakai, Shunsuke Kuroki, Jun-Ichiro Jo, Kazuo Hoshina, Yuki Fujimori, Kenji Oka, Toshiyasu Amano, Takahiro Yamanaka, Makoto Tachibana, Yasuhiko Tabata, Tanri Shiozawa, Osamu Ishizuka, Shinichi Hochi, Seiji Takashima
Both glial cell line-derived neurotrophic factor (GDNF) and fibroblast growth factor 2 (FGF2) are bona fide self-renewal factors for spermatogonial stem cells, whereas retinoic acid (RA) induces spermatogonial differentiation. In this study, we investigated the functional differences between FGF2 and GDNF in the germline niche by providing these factors using a drug delivery system in vivo. Although both factors expanded the GFRA1+ subset of undifferentiated spermatogonia, the FGF2-expanded subset expressed RARG, which is indispensable for proper differentiation, 1...
April 16, 2018: Stem Cell Reports
https://www.readbyqxmd.com/read/29660605/functional-assessment-of-spermatogonial-stem-cell-purity-in-experimental-cell-populations
#10
REVIEW
Tessa Lord, Jon M Oatley
Historically, research in spermatogonial biology has been hindered by a lack of validated approaches to identify and isolate pure populations of the various spermatogonial subsets for in-depth analysis. In particular, although a number of markers of the undifferentiated spermatogonial population have now been characterized, standardized methodology for assessing their specificity to the spermatogonial stem cell (SSC) and transit amplifying progenitor pools has been lacking. To date, SSC content within an undefined population of spermatogonia has been inferred using either lineage tracing or spermatogonial transplantation analyses which generate qualitative and quantitative data, respectively...
April 3, 2018: Stem Cell Research
https://www.readbyqxmd.com/read/29660000/spermatogonial-behavior-in-marmoset-a-new-generation-their-kinetics-and-niche
#11
A L Caldeira-Brant, L Eras-Garcia, D Alves-Freitas, F R C L Almeida, H Chiarini-Garcia
STUDY QUESTION: Could a more detailed evaluation of marmoset spermatogonial morphology, kinetics, and niches using high-resolution light microscopy (HRLM) lead to new findings? SUMMARY ANSWER: Three new classes of marmoset spermatogonia, which were not evenly distributed in terms of number and position along the basal membrane, and an extra premeiotic cell division not present in humans were identified using HRLM. WHAT IS KNOWN ALREADY: The seminiferous epithelium cycle (SEC) of marmosets is divided into nine stages when based on the acrosome system, and several spermatogenic stages can usually be recognized within the same tubular cross-section...
April 11, 2018: Molecular Human Reproduction
https://www.readbyqxmd.com/read/29657241/expression-dynamics-of-self-renewal-factors-for-spermatogonial-stem-cells-in-the-mouse-testis
#12
Mizuki Sakai, Kaito Masaki, Shota Aiba, Masaaki Tone, Seiji Takashima
Glial cell line-derived neurotrophic factor (GDNF) and fibroblast growth factor 2 (FGF2) are bona fide self-renewal factors for spermatogonial stem cells (SSCs). Although GDNF is indispensable for the maintenance of SSCs, the role of FGF2 in the testis remains to be elucidated. To clarify this, the expression dynamics and regulatory mechanisms of Fgf2 and Gdnf in the mouse testes were analyzed. It is well known that Sertoli cells express Gdnf, and its receptor is expressed in a subset of undifferentiated spermatogonia, including SSCs...
April 16, 2018: Journal of Reproduction and Development
https://www.readbyqxmd.com/read/29652044/-the-ultrastructure-of-sertoli-cells-and-spermatogonia-in-the-rats-exposed-to-radiation-under-conditions-of-therapeutic-and-prophylactic-application-of-low-intensity-electromagnetic-emission
#13
Y N Korolev, I P Bobrovnitskii, M S Geniatulina, L A Nikulina, L V Mikhailik
BACKGROUND: it has been demonstrated in various experimental studies that radiation exposure produces a negative impact on the processes of spermatogenesis associated with the disturbances of the microcirculation processes in the testes and the development of cellular and intracellular disintegration expressed as destructive changes in the cells leading to their death. AIM: The objective of the present study was to detect the ultrastructural abnormalities in the cells of Sertoli and spermatogonia under conditions of their exposure to radiation and to identify the peculiarities of their regeneration under the influence of the therapeutic and prophylactic application of low-intensity ultra-high frequency (UHF) electromagnetic radiation (EMR) and low-intensity low-frequency magnetic field (MF)...
April 9, 2018: Voprosy Kurortologii, Fizioterapii, i Lechebnoĭ Fizicheskoĭ Kultury
https://www.readbyqxmd.com/read/29649409/the-forkhead-transcription-factor-foxc2-is-required-for-maintaining-murine-spermatogonial-stem-cells
#14
Chao Wei, Hao Lin, Sheng Cui
Continuous spermatogenesis from puberty to old age in males relies on spermatogonial stem cells (SSCs) that possess the property of self-renewal and differentiation. The delicate balance between self-renewal and differentiation is of great importance. In mice, SSCs exist as a subpopulation of undifferentiated spermatogonia. SSCs are controlled by intrinsic molecular pathways which can be activated by extrinsic signals. Our results here first show that the expression of forkhead box C2 (FOXC2) is restricted to GFRα1 positive spermatogonia in the testis...
March 13, 2018: Stem Cells and Development
https://www.readbyqxmd.com/read/29649254/uxt-is-required-for-spermatogenesis-in-mice
#15
Eric D Schafler, Phillip A Thomas, Susan Ha, Yu Wang, Keria Bermudez-Hernandez, Zuojian Tang, David Fenyö, Margarita Vigodner, Susan K Logan
Male mammals must simultaneously produce prodigious numbers of sperm and maintain an adequate reserve of stem cells to ensure continuous production of gametes throughout life. Failures in the mechanisms responsible for balancing germ cell differentiation and spermatogonial stem cell (SSC) self-renewal can result in infertility. We discovered a novel requirement for Ubiquitous Expressed Transcript (UXT) in spermatogenesis by developing the first knockout mouse model for this gene. Constitutive deletion of Uxt is embryonic lethal, while conditional knockout in the male germline results in a Sertoli cell-only phenotype during the first wave of spermatogenesis that does not recover in the adult...
2018: PloS One
https://www.readbyqxmd.com/read/29617903/spermatogonial-stem-cells
#16
Hiroshi Kubota, Ralph L Brinster
Spermatogonial stem cells (SSCs) are the most primitive spermatogonia in the testis and have an essential role to maintain highly productive spermatogenesis by self-renewal and continuous generation of daughter spermatogonia that differentiate into spermatozoa, transmitting genetic information to the next generation. Since the 1950s, many experimental methods, including histology, immunostaining, whole-mount analyses, and pulse-chase labeling had been used in attempts to identify SSCs, but without success. In 1994, a spermatogonial transplantation method was reported that established a quantitative functional assay to identify SSCs by evaluating their ability to both self-renew and differentiate to spermatozoa...
March 30, 2018: Biology of Reproduction
https://www.readbyqxmd.com/read/29573661/expression-patterns-and-role-of-sdf-1-cxcr4-axis-in-boar-spermatogonial-stem-cells
#17
Hyun Jung Park, Won-Yong Lee, Jin Hoi Kim, Chankyu Park, Hyuk Song
The signaling of chemokine stromal cell-derived factor (SDF)-1 and its receptor C-X-C motif chemokine receptor 4 (CXCR4) is involved in the cellular proliferation, survival, and migration of various cell types. Although SDF-1/CXCR4 has been implicated in the maintenance of the spermatogonial population during mouse testis development, their expression patterns and functions in boar testis remain unclear. In the present study, the expression pattern of SDF-1 and CXCR4 was determined during pre-pubertal and post-pubertal stage boar testes and in vitro cultured porcine spermatogonial stem cells (pSSCs)...
March 15, 2018: Theriogenology
https://www.readbyqxmd.com/read/29524808/identification-of-type-a-spermatogonia-in-turbot-scophthalmus-maximus-using-a-new-cell-surface-marker-of-lymphocyte-antigen-75-ly75-cd205
#18
Chunyan Zhao, Qinghua Liu, Shihong Xu, Yongshuang Xiao, Wenqi Wang, Jingkun Yang, Yang Yang, Yanfeng Wang, Zongcheng Song, Jun Li
Turbot (Schophthalmus maximus) is one of the most important economic marine flatfish species. However, due to rapid development of the industry, genetic resource recession has brought down the efficiency of aquaculture. Therefore, conservation of the genetic resource is increasingly demanded. Recent research proved that type A spermatogonia possesses the properties of spermatogonia stem cell, and it might provide an ideal solution. Therefore, it is necessary to develop an appropriate molecular marker on type A spermatogonia to further isolate and purify of type A spermatogonia in turbot...
June 2018: Theriogenology
https://www.readbyqxmd.com/read/29492477/evaluation-of-the-effect-of-follicular-stimulating-hormone-on-the-in-vitro-bovine-spermatogonial-stem-cells-self-renewal-an-experimental-study
#19
Masoome Jabarpour, Parviz Tajik
Background: Spermatogonial stem cells (SSCs) are undifferentiated cells which are highly reproducible and expandable. Several studies have been conducted to reproduce these cells in culture. They used growth factors, hormones and different feeder cells to improve survival and proliferation of SSCs. Objective: This study was conducted to evaluate the effects of follicular stimulating hormone (FSH) on gene expression of fibroblast growth factor (FGF2) and glial cell-derived neurotrophic factor (GDNF) in Sertoli cells...
December 2017: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/29492312/exposure-to-phthalate-esters-induces-an-autophagic-response-in-male-germ-cells
#20
Paula Valenzuela-Leon, Ina Dobrinski
Phthalate esters are plasticizers that impart flexibility to polvinylchloride plastics. As they are not covalently bound, they can leach from a wide range of products, including food containers, medical devices, clothing, and toys, leading to widespread environmental exposure. Phthalate toxicity has been linked to male infertility by disrupting testosterone production and testis development. Phthalates also impair proliferation and viability of spermatogonial stem cells (SSC), the role of which is to support lifelong spermatogenesis...
July 2017: Environmental Epigenetics
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