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Non ischemic cardiomyopathy

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https://www.readbyqxmd.com/read/28919378/sudden-death-mechanisms-in-non-ischemic-cardiomyopathies-insights-gleaned-from-clinical-implantable-cardioverter-defibrillator-trials
#1
Benjamin A Steinberg, Siva K Mulpuru, James C Fang, Bernard J Gersh
Sudden cardiac death (SCD) represents a major cause of death among patients with heart failure. While scar-based, macro-reentrant ventricular tachycardia and ventricular fibrillation (VT/VF) is the primary etiology for SCD among patients with ischemic cardiomyopathy, a more diverse set of mechanisms and substrates are likely at play for the diverse group of patients characterized by non-ischemic, dilated cardiomyopathy (NICM). These causes may include scar-based re-entry, but also neurohormonal stimulation (sympathetic, parasympathetic, renin-angiotensin-aldosterone), inflammation, and non-arrhythmic processes occurring in the context of a genetic predisposition...
September 14, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28915329/mitophagy-as-a-protective-mechanism-against-myocardial-stress
#2
Jihoon Nah, Shigeki Miyamoto, Junichi Sadoshima
Mitochondria are dynamic organelles that can undergo fusion, fission, biogenesis, and autophagic elimination to maintain mitochondrial quality control. Since the heart is in constant need of high amounts of energy, mitochondria, as a central energy supply source, play a crucial role in maintaining optimal cardiac performance. Therefore, it is reasonable to assume that mitochondrial dysfunction is associated with the pathophysiology of heart diseases. In non-dividing, post-mitotic cells such as cardiomyocytes, elimination of dysfunctional organelles is essential to maintaining cellular function because non-dividing cells cannot dilute dysfunctional organelles through cell division...
September 12, 2017: Comprehensive Physiology
https://www.readbyqxmd.com/read/28903763/troponin-as-ischemic-biomarker-is-related-with-all-three-echocardiographic-risk-factors-for-sudden-death-in-hypertrophic-cardiomyopathy-esc-guidelines-2014
#3
Rafał Hładij, Renata Rajtar-Salwa, Paweł Petkow Dimitrow
BACKGROUND: Sudden cardiac death (SCD) risk stratification is the most important preventive action in patients with hypertrophic cardiomyopathy (HCM). The identification of the ischemia biomarker high sensitive troponin I (hs-TnI) role for this arrhythmic disease may provide additional information for SCD risk stratification. The aim of the study was to compare echocardiographic parameters (prognostic for risk stratification of SCD in HCM) among two subgroups of HCM patients: with elevated hs-TnI versus non-elevated hs-TnI level...
September 13, 2017: Cardiovascular Ultrasound
https://www.readbyqxmd.com/read/28890876/implantable-cardioverter-defibrillator-in-non-ischemic-cardiomyopathy-a-meta-analysis-of-randomized-controlled-trials
#4
Ahmad Masri, Muhammad Hammadah, Evan Adelstein, Sandeep Jain, Samir Saba
BACKGROUND: Sudden cardiac death (SCD) is a significant cause of mortality in patients with non-ischemic cardiomyopathy (NICM). Implantable cardioverter defibrillators (ICDs) are currently indicated for the primary prevention of SCD in these patients. Conflicting results from published randomized controlled trials (RCTs) have recently questioned the protective role of ICD in NICM patients to perform an updated meta-analysis of the effect of ICDs on outcomes of NICM patients. METHODS: We performed a search of PubMed, EMBASE, and Cochrane databases for RCTs comparing ICD to medical therapy in patients with NICM...
August 2017: Cardiovascular Diagnosis and Therapy
https://www.readbyqxmd.com/read/28870505/tgf-%C3%AE-1-affects-cell-cell-adhesion-in-the-heart-in-an-ncam1-dependent-mechanism
#5
Maegen A Ackermann, Jennifer M Petrosino, Heather R Manring, Patrick Wright, Vikram Shettigar, Ahmet Kilic, Paul M L Janssen, Mark T Ziolo, Federica Accornero
The contractile property of the myocardium is maintained by cell-cell junctions enabling cardiomyocytes to work as a syncytium. Alterations in cell-cell junctions are observed in heart failure, a disease characterized by the activation of Transforming Growth Factor beta 1 (TGFβ1). While TGFβ1 has been implicated in diverse biologic responses, its molecular function in controlling cell-cell adhesion in the heart has never been investigated. Cardiac-specific transgenic mice expressing active TGFβ1 were generated to model the observed increase in activity in the failing heart...
September 1, 2017: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/28861149/posttranslational-modifications-of-calcium-calmodulin-dependent-protein-kinase-ii%C3%AE-and-its-downstream-signaling-in-human-failing-hearts
#6
Tomas Rajtik, Eva Goncalvesova, Zoltan V Varga, Przemyslaw Leszek, Mariusz Kusmierczyk, Michal Hulman, Jan Kyselovic, Peter Ferdinandy, Adriana Adameova
BACKGROUND: In human failing hearts (HF) of different origin (coronary artery disease-CAD, dilated-DCM, restrictive and hypertrophic cardiomyopathy-OTHER), we investigated the active forms of Ca(2+)/calmodulin-dependent protein kinase IIδ (p-Thr(287)-CaMKIIδ, oxMet(281/282)-CaMKIIδ) and their role in phenotypes of the disease. METHODS AND RESULTS: Although basic diagnostic and clinical markers indicating the attenuated cardiac contractility and remodeling were comparable in HF groups, CaMKIIδ-mediated axis was different...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28857211/the-impact-of-changes-in-lvef-and-renal-function-on-the-prognosis-of-icd-patients-after-elective-device-replacement
#7
Bert Vandenberk, Tomas Robyns, Christophe Garweg, Vincent Floré, Stefaan Foulon, Gabor Voros, Joris Ector, Rik Willems
BACKGROUND: A proportion of patients with an ICD in prevention of sudden cardiac death will only receive their first appropriate ICD therapy (AT) after device replacement. Clinical reassessment at the time of replacement could be helpful to guide the decision to replace or not in the future. METHODS: All patients with an ICD for primary or secondary prevention in ischemic (ICM) or non-ischemic cardiomyopathy were included in a single-center retrospective registry...
August 30, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/28843420/profound-differences-in-prognostic-impact-of-left-ventricular-reverse-remodeling-after-cardiac-resynchronization-therapy-relate-to-heart-failure-etiology
#8
Pieter Martens, Petra Nijst, Frederik H Verbrugge, Matthias Dupont, W H Wilson Tang, Wilfried Mullens
BACKGROUND: An ischemic etiology of heart failure (HF) has been associated with reduced left ventricular reverse remodeling after cardiac resynchronization therapy (CRT). OBJECTIVE: The purpose of this study was to assess the relationship between the etiology of HF and reverse remodeling and outcome after CRT. METHODS: Consecutive patients undergoing CRT implantation between October 2008 and August 2015 were retrospectively evaluated. Coronary angiography classified ischemic vs nonischemic etiology...
August 24, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28842918/who-still-remains-at-risk-of-arrhythmic-death-at-time-of-implantable-cardioverter-defibrillator-generator-replacement
#9
Marta Madeira, Natália António, James Milner, Miguel Ventura, João Cristóvão, Marco Costa, José Nascimento, Luís Elvas, Lino Gonçalves, Guilherme Mariano Pego
BACKGROUND: Implantable cardioverter-defibrillator (ICD) is associated with reduction in arrhythmic mortality. However, at the time of generator replacement (GR) some patients had not experienced therapies and had a different clinical profile. Therefore, the risk-benefit ratio of ICD may have changed. Our aim was to determine the proportion of patients with ICD implanted in primary prevention that maintain guideline-derived indications at the time of GR and assess predictors of therapies in the post-replacement period...
August 26, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/28840451/early-prediction-of-cardiac-resynchronization-therapy-response-by-non-invasive-electrocardiogram-markers
#10
Nuria Ortigosa, Víctor Pérez-Roselló, Víctor Donoso, Joaquín Osca, Luis Martínez-Dolz, Carmen Fernández, Antonio Galbis
Cardiac resynchronization therapy (CRT) is an effective treatment for those patients with severe heart failure. Regrettably, there are about one third of CRT "non-responders", i.e. patients who have undergone this form of device therapy but do not respond to it, which adversely affects the utility and cost-effectiveness of CRT. In this paper, we assess the ability of a novel surface ECG marker to predict CRT response. We performed a retrospective exploratory study of the ECG previous to CRT implantation in 43 consecutive patients with ischemic (17) or non-ischemic (26) cardiomyopathy...
August 24, 2017: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/28822689/cholesterol-lowering-gene-therapy-counteracts-the-development-of-non-ischemic-cardiomyopathy-in-mice
#11
Ilayaraja Muthuramu, Ruhul Amin, Andrey Postnov, Mudit Mishra, Joseph Pierre Aboumsallem, Tom Dresselaers, Uwe Himmelreich, Paul P Van Veldhoven, Olivier Gheysens, Frank Jacobs, Bart De Geest
A causal role of hypercholesterolemia in non-ischemic heart failure has never been demonstrated. Adeno-associated viral serotype 8 (AAV8)-low-density lipoprotein receptor (AAV8-LDLr) gene transfer was performed in LDLr-deficient mice without and with pressure overload induced by transverse aortic constriction (TAC). AAV8-LDLr gene therapy resulted in an 82.8% (p < 0.0001) reduction of plasma cholesterol compared with controls. Mortality rate was lower (p < 0.05) in AAV8-LDLr TAC mice compared with control TAC mice (hazard ratio for mortality 0...
August 1, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/28822388/outcomes-following-noncardiac-surgery-in-patients-with-ventricular-assist-devices-a-single-center-experience
#12
Shawna M Kettyle, Nikhil L Chervu, Appajosula Sarada Rao, Salaam Sadi, David Majure, Jack A Sava, Laura S Johnson
the prevalence of ventricular assist devices (VADs) is increasing as advanced cardiac therapies progress. These patients commonly require non-cardiac surgical procedures (NCS), although data are scant regarding the safety, timing, and operations that may safely be performed. We aim to describe our experience with VAD patients undergoing NCS. We retrospectively reviewed records on patients who underwent NCS after VAD implantation between 2013 and 2015 at a single Joint Commission-accredited VAD institution. Data collection included demographics, ischemic cardiomyopathy or nonischemic cardiomyopathy, operative details, and perioperative anticoagulation management and outcomes...
August 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28812383/evaluation-of-relationship-between-coronary-artery-status-evaluated-by-coronary-computed-tomography-angiography-and-development-of-cardiomyopathy-in-carbon-monoxide-poisoned-patients-with-myocardial-injury-a-prospective-observational-study
#13
Yong Sung Cha, Hyun Kim, Yoonsuk Lee, Woocheol Kwon, Jung-Woo Son, Hyun Youk, Hyung Il Kim, Oh Hyun Kim, Kyung Hye Park, Kyoung-Chul Cha, Kang Hyun Lee, Sung Oh Hwang
OBJECTIVES: Whether coronary artery changes are a main mechanism in the development of carbon monoxide (CO)-induced cardiomyopathy remains unknown. We investigated the effects of coronary artery stenosis on the presence or patterns of cardiomyopathy in CO-poisoned patients with myocardial injury defined as elevation of troponin I. MATERIALS AND METHODS: This prospective observational study collected data from consecutive patients who were diagnosed with CO poisoning and myocardial injury during the 24-month study period...
August 16, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28793004/abnormal-diastolic-function-underlies-the-different-beneficial-effects-of-cardiac-resynchronization-therapy-on-ischemic-and-non-ischemic-cardiomyopathy
#14
Qi Wang, Kang-Yu Chen, Fei Yu, Hao Su, Chun-Sheng An, Yang Hu, Dong-Mei Yang, Jian Xu, Ji Yan
OBJECTIVES: To investigate the association between diastolic function and the different beneficial effects of cardiac resynchronization therapy in patients with heart failure due to different causes. METHODS: The 104 enrolled patients were divided into an ischemic cardiomyopathy group (n=27) and a non-ischemic cardiomyopathy group (n=77) according to the cause of heart failure. Before implantation, left ventricular diastolic function was evaluated in all patients using echocardiography...
July 2017: Clinics
https://www.readbyqxmd.com/read/28772045/translational-registry-for-cardiomyopathies-torch-rationale-and-first-results
#15
Claudia Seyler, Benjamin Meder, Tanja Weis, Thea Schwaneberg, Kerstin Weitmann, Wolfgang Hoffmann, Hugo A Katus, Andreas Dösch
AIMS: Non-ischemic cardiomyopathies (CMPs) comprise heart muscle disorders of different causes with high variability in disease phenotypes and clinical progression. The lack of national structures for the efficient recruitment, clinical and molecular classification, and follow-up of patients with non-ischemic CMPs limit the thorough analysis of disease mechanisms and the evaluation of novel diagnostic and therapeutic strategies. This paper describes a national, prospective, multicenter registry for patients with non-ischemic CMPs...
August 2017: ESC Heart Failure
https://www.readbyqxmd.com/read/28761607/-severe-ventricular-arrhythmias-in-a-patient-with-dilated-cardiomyopathy-and-automated-implantable-defibrillator-aid
#16
Stéphane Méo Ikama, Jospin Makani, Bertrand Ellenga-Mbolla, Louis Igor Ondze-Kafata, Thierry Raoul Gombet, Gisèle Kimbally-Kaky
Severe ventricular arrhythmias are frequent during heart failure; they are a life-threatening condition due to the increased risk of sudden death. Efficient management remains limited in sub-Saharan Africa because of the limited or unavailable medical resources as automated implantable defibrillator (AID). We report the case of a 56-year old patient with non ischemic dilated cardiomyopathy with very low left ventricular ejection fraction (LVEF)who underwent AID implantation for primary prevention of sudden cardiac death due to ventricular arrhythmias in 2012...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28756100/clinical-recognition-of-pure-premature-ventricular-complex-induced-cardiomyopathy-at-presentation
#17
Diego Penela, Juan Fernández-Armenta, Luis Aguinaga, Luis Tercedor, Augusto Ordoñez, Felipe Bisbal, Juan Acosta, Luca Rossi, Roger Borras, Adelina Doltra, José T Ortiz-Pérez, Xavier Bosch, Rosario J Perea, Susana Prat-González, David Soto-Iglesias, Jose M Tolosana, Francesca Vassanelli, Mario Cabrera, Markus Linhart, Mikel Martinez, Lluis Mont, Antonio Berruezo
BACKGROUND: Frequent premature ventricular complexes (PVCs) can induce or worsen left ventricular (LV) systolic dysfunction. OBJECTIVE: The purpose of this study was to identify the clinical pattern of patients having a "pure PVC-induced" cardiomyopathy at presentation. METHODS: This prospective multicenter study included 155 consecutive patients (age 55 ± 12 years, 96 men [62%], 23% ±12% mean PVC burden) with LV dysfunction and frequent PVCs submitted for ablation and followed up for at least 12 months...
July 27, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28756099/predictors-of-ventricular-arrhythmia-after-left-ventricular-assist-device-implantation-a-large-single-center-observational-study
#18
Elena Efimova, Julia Fischer, Livio Bertagnolli, Borislav Dinov, Simon Kircher, Sascha Rolf, Philipp Sommer, Andreas Bollmann, Sergio Richter, Anna Meyer, Jens Garbade, Gerhard Hindricks, Arash Arya
BACKGROUND: Ventricular arrhythmias (VAs) are common in patients after left ventricular assist device (LVAD) implantation. OBJECTIVE: The purpose of this study was to determine the predictors of VAs and their impact on mortality in LVAD patients. METHODS: A total of 98 consecutive patients with an implantable cardioverter-defibrillator (ICD) (86 [88%] male, mean age 57 ± 10 years), 57 [58%] with nonischemic dilated cardiomyopathy) who had received an LVAD between May 2011 and December 2013 at our institution were included in the study...
July 27, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28756079/-exercise-testing-new-guidelines
#19
Dany Michel Marcadet
The GERS (Exercise Rehabilitation and Sports Group of the French Society of Cardiology) has decided to update current guidelines regarding the practice of EKG stress tests. Since the last update dates from 1997, the GERS judged it necessary to integrate data from new works and advancements made in the last 20 years. Good clinical practices and safety conditions are better defined regarding the structure, location, material, staff competency, as well as convention with hospital structures. The diagnosis of coronary artery disease remains the principal indication for a stress test...
July 2017: La Presse Médicale
https://www.readbyqxmd.com/read/28752228/the-dx-af-study-a-prospective-multicenter-randomized-controlled-trial-comparing-vdd-icd-to-vvi-icd-in-detecting-sub-clinical-atrial-fibrillation-in-defibrillator-patients
#20
Mohammed Shurrab, Amir Janmohamed, Jean-François Sarrazin, Felix Ayala-Paredes, Marcio Sturmer, Randall Williams, Satish Toal, Chris Lane, Kevin E Thorpe, Jeff S Healey, Eugene Crystal
PURPOSE: Atrial fibrillation (AF) is the most common cardiac dysrhythmia. Appropriate detection of AF and early initiation of oral anticoagulation therapy are critical to reduce the risk of stroke. Patients with implantable cardioverter defibrillators (ICD) are at high risk of developing AF. The purpose of the Dx-AF study is to demonstrate that a novel single-lead VDD-ICD system (Linox smart S DX) will facilitate adequate recognition of sub-clinical AF and ultimately stroke prevention with a comparable safety profile in comparison to VVI-ICD...
July 27, 2017: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
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