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Non ischemic cardiomyopathy

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https://www.readbyqxmd.com/read/28054710/atypical-surface-ecg-complicating-the-diagnosis-of-bundle-branch-reentry-tachycardia
#1
Christopher Reithmann, Bernhard Herkommer, Thomas Remp, Michael Fiek
BACKGROUND: Typical left bundle branch block (LBBB) during ventricular tachycardia (VT) is a diagnostic criterion of bundle branch reentry tachycardia (BBRT) with activation of the right bundle in the anterograde direction. METHODS AND RESULTS: 11 patients (7 male, 60 ± 12 years) with non-ischemic cardiomyopathy (left ventricular ejection fraction 37 ± 16 %) presenting with BBRT were successfully treated by ablation of the right bundle. Among them, 5 patients had atypical surface ECGs differing from a typical left bundle branch block during the VT...
January 5, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/28045413/vitamin-d-levels-predict-the-response-to-cardiac-resynchronization-therapy-in-patients-with-systolic-heart-failure
#2
Hamza Sunman, Adem Özkan, Hikmet Yorgun, Uğur Canpolat, Naresh Maharjan, Serkan Asil, Ergün Barış Kaya, Tülin Bayrak, Lale Tokgözoğlu, Asuman Özkara, Kudret Aytemir, Ali Oto
OBJECTIVE: The aim of this study was to examine the relationship between vitamin D levels in patients with heart failure (HF) and response to cardiac resynchronization therapy (CRT). METHODS: We studied 57 patients (mean age: 60.47±13.09 years) with New York Heart Association Class II or III heart failure, QRS duration ?120 milliseconds, and ejection fraction <35% (mean: 27.1±4.4%) who underwent CRT. All patients were taking optimal medical treatment for HF...
December 2016: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/28041705/using-coronary-calcification-to-exclude-an-ischemic-etiology-for-cardiomyopathy-a-validation-study-and-systematic-review
#3
Manuja Premaratne, Mohabbat Shamsaei, Jonathan D H Chow, Tony Haddad, Fernanda Erthal, Helen Curran, Yeung Yam, Agnieszka Szczotka, Lisa Mielniczuk, George A Wells, Rob S Beanlands, Alomgir Hossain, Benjamin J W Chow
BACKGROUND: Preliminary data suggests the absence of coronary artery calcification (CAC) excludes ischemic etiologies of cardiomyopathy. We prospectively validate and perform a systematic review to determine the utility of an Agatston score=0 to exclude the diagnosis of ischemic cardiomyopathy. METHODS AND RESULTS: Patients with newly diagnosed LV dysfunction were prospectively enrolled. Patients underwent CAC imaging and were followed until an etiologic diagnosis of cardiomyopathy was made...
December 20, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/28038817/low-partial-pressure-of-end-tidal-carbon-dioxide-predicts-left-ventricular-assist-device-implantation-in-patients-with-advanced-chronic-heart-failure
#4
Osamu Seguchi, Eriko Hisamatsu, Atsushi Nakano, Seiko Nakajima, Kensuke Kuroda, Takuya Watanabe, Takuma Sato, Haruki Sunami, Masanobu Yanase, Hiroki Hata, Toshimitsu Hamasaki, Tomoyuki Fujita, Junjiro Kobayashi, Takeshi Nakatani, Masafumi Kitakaze, Norihide Fukushima
BACKGROUND: This study aimed to clarify the prognostic impact of partial pressure of end-tidal carbon dioxide (PETCO2) in patients with advanced chronic heart failure (HF). METHODS: Forty-eight patients (mean age 43.1±11.9years, 32 males) with chronic HF (44 with non-ischemic and 4 with ischemic cardiomyopathy) were prospectively enrolled. Echocardiography, blood tests, pulmonary function testing, and PETCO2 measurements were performed as noninvasive tests, whereas right heart catheterization and arterial blood gas analysis were conducted as invasive tests...
December 21, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/28025038/incidence-and-risk-of-cardiac-events-in-patients-with-previously-treated-multiple-myeloma-versus-matched-patients-without-multiple-myeloma-an-observational-retrospective-cohort-study
#5
Kristin D Kistler, Jill Kalman, Gagan Sahni, Brian Murphy, Winifred Werther, Kanya Rajangam, Ajai Chari
BACKGROUND: Multiple myeloma (MM) patients have age-, disease-, and treatment-related risk factors for cardiac events. MATERIALS AND METHODS: We analyzed the 2006 to 2011 MarketScan database to determine whether the risk of cardiac events is greater in MM patients than in non-MM patients. Included were 1723 MM patients treated with corticosteroids and ≥ 3 drugs (bortezomib, immunomodulatory derivatives, and alkylating agents or anthracyclines). The index date (ID) was the date on which the 3-drug exposure criterion was met...
November 22, 2016: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/28008413/gastrointestinal-symptoms-from-left-ventricular-assist-device-external-compression-of-the-gastric-lumen
#6
Jorge Suarez, Dennis Yang
A 74-year-old man with a left-ventricular assist device (LVAD) as destination therapy for end-stage ischemic cardiomyopathy presented with acute upper gastrointestinal bleeding. Other symptoms included chronic early satiety, intermittent nausea, and non-specific abdominal discomfort since LVAD implantation 3 years ago. An actively bleeding duodenal arteriovenous malformation was successfully treated with endoscopic coagulation. There was also evidence of moderate external compression of the anterior gastric wall from the LVAD pump with luminal narrowing in the antrum...
August 2016: ACG Case Reports Journal
https://www.readbyqxmd.com/read/27993908/implantable-cardioverter-defibrillator-for-non-ischemic-cardiomyopathy-an-updated-meta-analysis
#7
Harsh Golwala, Navkaranbir Singh Bajaj, Garima Arora, Pankaj Arora
Use of Implantable cardioverter-defibrillators (ICD) have been a major advancement in patients with ischemic cardiomyopathy (ICM) with reduced ejection fraction <35%.(1) While the data supporting the use of ICDs are robust in patients with ICM, limited randomized controlled clinical trial (RCT) data exist for similar benefit in patients with non-ischemic cardiomyopathy (NICM).(2) A prior meta-analysis that included both primary and secondary prevention ICD trials in 2004 by Desai et al. demonstrated a 31% reduction in all-cause mortality with ICD use in patients with NICM...
December 19, 2016: Circulation
https://www.readbyqxmd.com/read/27993408/antithrombotic-treatment-and-characteristics-of-elderly-patients-with-non-valvular-atrial-fibrillation-hospitalized-at-internal-medicine-departments-nonavasc-registry
#8
Alejandra Gullón, Carmen Suárez, Jesús Díez-Manglano, Francesc Formiga, José María Cepeda, Antonio Pose, Miguel Camafort, Jesús Castiella, Eduardo Rovira, José María Mostaza
BACKGROUND AND OBJETIVES: The prevalence of non-valvular atrial fibrillation (NVAF) increases with the patient's age and is associated with high morbi-mortality rates. The main goal of this study was to describe the characteristics of hospitalized elderly patients with NVAF and to identify the clinical and functional factors which determine the use of different antithrombotic strategies. PATIENTS AND METHODS: Observational, prospective, multicentre study carried out on patients with NVAF over the age of 75, who had been admitted for any medical condition to Internal Medicine departments...
December 16, 2016: Medicina Clínica
https://www.readbyqxmd.com/read/27979675/temporal-change-of-myocardial-tissue-character-is-associated-with-left-ventricular-reverse-remodeling-in-patients-with-dilated-cardiomyopathy-a-cardiovascular-magnetic-resonance-study
#9
Takeru Nabeta, Takayuki Inomata, Teppei Fujita, Yuichiro Iida, Yuki Ikeda, Takanori Sato, Shunsuke Ishii, Emi Maekawa, Tomohiro Mizutani, Takashi Naruke, Toshimi Koitabashi, Yusuke Inoue, Junya Ako
BACKGROUND: Prognostic significance of temporal change in myocardial tissue characterization by cardiovascular magnetic resonance (CMR) has not been elucidated in patients with non-ischemic dilated cardiomyopathy (DCM). METHODS AND RESULTS: Sixty-eight patients with newly-diagnosed DCM who underwent CMR including late gadolinium enhancement (LGE) both at baseline and during follow-up period were enrolled. LGE score was defined by a signal intensity of ≥5 standard deviations above the remote reference myocardium mean...
December 12, 2016: Journal of Cardiology
https://www.readbyqxmd.com/read/27959282/neonates-of-diabetic-mothers-the-starting-point-for-developing-novel-therapeutic-approaches-to-ischemic-heart-and-brain
#10
Raffaella Mormile
Diabetes mellitus represents the most common medical condition causing complications during pregnancy. However, there is still some controversy surrounding complications. Maternal hyperglycemia leads to fetal hyperglycemia. Offspring of diabetic mothers compensate excess glucose concentrations by producing higher levels of insulin causing transient hyperinsulinemia. Infants of diabetic mothers are at risk for congenital cardiac malformations, of which 40% are with hypertrophic cardiomyopathy. However, regardless of severity, cardiac hypertrophy is transient with echocardiographic resolution within the first months after birth...
November 2016: Medical Hypotheses
https://www.readbyqxmd.com/read/27940336/myocardial-t1-measurement-predicts-beneficial-lv-remodeling-after-long-term-heart-failure-therapy
#11
William S Bradham, Susan P Bell, Douglas W Adkisson, Holly M Smith, Frank E Harrell, Mark A Lawson, Henry Ooi, Douglas B Sawyer, Marvin W Kronenberg
OBJECTIVE: We assessed the hypothesis that interstitial myocardial fibrosis measured by cardiac magnetic resonance imaging (CMR) predicts left ventricular (LV) beneficial remodeling in non-ischemic dilated cardiomyopathy (NIDCM) after heart failure (HF) treatment including mineralocorticoid receptor antagonists (MRA). BACKGROUND: The myocardial longitudinal relaxation time (T1) on CMR, can quantify myocardial fibrosis in the presence or absence of visually detectable late gadolinium (Gd) enhancement (LGE) MRA treatment produces beneficial remodeling in NIDCM...
December 8, 2016: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/27936202/new-altered-non-fibrillar-collagens-in-human-dilated-cardiomyopathy-role-in-the-remodeling-process
#12
Carolina Gil-Cayuela, Esther Roselló-LLetí, Ana Ortega, Estefanía Tarazón, Juan Carlos Triviño, Luis Martínez-Dolz, José Ramón González-Juanatey, Francisca Lago, Manuel Portolés, Miguel Rivera
BACKGROUND: In dilated cardiomyopathy (DCM), cardiac failure is accompanied by profound alterations of extracellular matrix associated with the progression of cardiac dilation and left ventricular (LV) dysfunction. Recently, we reported alterations of non-fibrillar collagen expression in ischemic cardiomyopathy linked to fibrosis and cardiac remodeling. We suspect that expression changes in genes coding for non-fibrillar collagens may have a potential role in DCM development. OBJECTIVES: This study sought to analyze changes in the expression profile of non-fibrillar collagen genes in patients with DCM and to examine relationships between cardiac remodeling parameters and the expression levels of these genes...
2016: PloS One
https://www.readbyqxmd.com/read/27931223/pattern-and-prognostic-value-of-cardiac-involvement-in-patients-with-late-onset-pompe-disease-a-comprehensive-cardiovascular-magnetic-resonance-approach
#13
Matthias Boentert, Anca Florian, Bianca Dräger, Peter Young, Ali Yilmaz
BACKGROUND: Pompe disease is an autosomal recessive disorder caused by deficiency of the lysosomal α-1,4-glucosidase leading to accumulation of glycogen in target tissues with progressive organ failure. While the early infantile-onset form is characterized by early severe hypertrophic cardiomyopathy with cardiac and respiratory failure, clinically relevant cardiomyopathy seems to be uncommon in patients with late-onset Pompe disease, and the prevalence and nature of myocardial abnormalities are still to be clarified...
December 7, 2016: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/27930686/comparison-of-ventricular-inducibility-with-late-gadolinium-enhancement-and-myocardial-inflammation-in-endomyocardial-biopsy-in-patients-with-dilated-cardiomyopathy
#14
Karin A L Mueller, Christian Heck, David Heinzmann, Johannes Schwille, Karin Klingel, Reinhard Kandolf, Ulrich Kramer, Michael Gramlich, Tobias Geisler, Meinrad P Gawaz, Juergen Schreieck, Peter Seizer
BACKGROUND: Risk stratification of patients with non-ischemic dilated cardiomyopathy remains a matter of debate in the era of device implantation. OBJECTIVE: We investigated associations between histopathological findings, contrast-enhanced cardiac MRI and the inducibility of ventricular tachycardia (VT) or fibrillation (VF) in programmed ventricular stimulation. METHODS: 56 patients with impaired left ventricular ejection fraction (LVEF≤50%, mean 36...
2016: PloS One
https://www.readbyqxmd.com/read/27925329/fragmented-qrs-is-a-novel-risk-factor-for-ventricular-arrhythmic-events-after-receiving-cardiac-resynchronization-therapy-in-non-ischemic-cardiomyopathy
#15
Miyako Igarashi, Hiroshi Tada, Hiro Yamasaki, Kenji Kuroki, Tomoko Ishizu, Yoshihiro Seo, Takeshi Machino, Nobuyuki Murakoshi, Yukio Sekiguchi, Yuichi Noguchi, Akihiko Nogami, Kazutaka Aonuma
INTRODUCTION: A fragmented QRS (fQRS) is reported to be associated with a poor prognosis or sudden cardiac death (SCD) in patients with Brugada syndrome or ischemic heart disease. However, no studies have clarified the impact of the presence of an fQRS on SCD or ventricular arrhythmic events in patients receiving cardiac resynchronization therapy (CRT). This study aimed to clarify this point in patients with non-ischemic cardiomyopathy. METHODS AND RESULTS: This study included 137 heart failure patients with non-ischemic cardiomyopathy who received CRT (NYHA functional class: II/III/IV = 25/84/28)...
December 7, 2016: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/27909478/cardiac-resynchronization-therapy-in-non-ischemic-cardiomyopathy
#16
REVIEW
Miriam Shanks Md PhD, Victoria Delgado Md PhD, Jeroen J Bax Md PhD
Cardiac resynchronization therapy (CRT) is an established therapy for heart failure patients who remain symptomatic despite optimal medical therapy, have reduced left ventricular ejection fraction (<35%) and wide QRS duration (>120 ms), preferably with left bundle branch block morphology. The response to CRT depends on the cardiac substrate: presence of correctable left ventricular mechanical dyssynchrony, presence of myocardial fibrosis (scar) and position of the left ventricular pacing lead. Patients with non-ischemic cardiomyopathy have shown higher response rates to CRT compared with patients with ischemic cardiomyopathy...
February 2016: Journal of Atrial Fibrillation
https://www.readbyqxmd.com/read/27905927/characteristics-and-outcomes-of-diabetic-patients-with-an-implantable-cardioverter-defibrillator-in-a-real-world-setting-results-from-the-israeli-icd-registry
#17
Hillel Steiner, Michael Geist, Ilan Goldenberg, Mahmoud Suleiman, Michael Glikson, Alexander Tenenbaum, Moshe Swissa, Enrique Z Fisman, Gregory Golovchiner, Boris Strasberg, Alon Barsheshet
AIMS: There are limited data regarding the effect of diabetes mellitus (DM) on the risks of both appropriate and inappropriate implantable cardioverter defibrillator (ICD) therapy. The present study was designed to compare the outcome of appropriate and inappropriate ICD therapy in patients with or without DM. METHODS AND RESULTS: The risk of a first appropriate ICD therapy for ventricular tachyarrhythmias (including anti tachycardia pacing and shock) was compared between 764 DM and 1346 non-DM patients enrolled in the national Israeli ICD registry...
December 1, 2016: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/27903393/-a-multi-center-study-on-the-long-term-mortality-and-related-risk-factors-in-patients-with-chronic-heart-failure-receiving-resynchronization-therapy
#18
S Y Qi, D M Wang, H B Yu, C Ding, F L Tian, L S Ru, J Li, B Zhang, Y L Han
Objective: To analyze long-term mortality and patients characteristics of cardiac resynchronization therapy (CRT) for patients with chronic heart failure. Methods: In-patients with chronic heart failure who received CRT in the three medical centers(Bethune International Peace Hospital, General Hospital of Shenyang Military Command of Chinese People's Liberation Army, and 251 Hospital of People's Liberation Army)from March 2001 to June 2013 were included.Mortality and related causes, echocardiographic parameters were analyzed...
November 24, 2016: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/27903390/-current-status-of-antiarrhythmic-drug-use-and-safety-assessment-in-chinese-patients-with-atrial-fibrillation
#19
R He, X Du, S W Liu, L J Sun, Y Li, H Zeng, Y Y Li, C Sun, Y Zhang, C S Ma, W Gao
Objective: To investigate the current status of antiarrhythmic drugs (AADs) use in Chinese patients with atrial fibrillation(AF) and assess the safety of AADs in this patient cohort. Methods: From January 2011 to December 2013, a total of 4 008 AF patients treated with AADs was enrolled in this study and patients were followed up for 24 months. Detailed information of prescribed drug, the causes of drug discontinuation and side effects were recorded. Results: Amiodarone was prescribed to 64.3%(2 579 cases) and propafenone to 31...
November 24, 2016: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/27884156/targeted-myocardial-gene-expression-in-failing-hearts-by-rna-sequencing
#20
Kajari Dhar, Alexandra M Moulton, Eric Rome, Fang Qiu, Jeff Kittrell, Eugenia Raichlin, Ronald Zolty, John Y Um, Michael J Moulton, Hesham Basma, Daniel R Anderson, James D Eudy, Brian D Lowes
BACKGROUND: Myocardial recovery with left ventricular assist device (LVAD) therapy is highly variable and difficult to predict. Next generation ribonucleic acid (RNA) sequencing is an innovative, rapid, and quantitative approach to gene expression profiling in small amounts of tissue. Our primary goal was to identify baseline transcriptional profiles in non-ischemic cardiomyopathies that predict myocardial recovery in response to LVAD therapy. We also sought to verify transcriptional differences between failing and non-failing human hearts...
November 25, 2016: Journal of Translational Medicine
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