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Non ischemic cardiomyopathy

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https://www.readbyqxmd.com/read/28325782/aibp-limits-angiogenesis-thorough-%C3%AE-secretase-mediated-upregulation-of-notch-signaling
#1
Renfang Mao, Shu Meng, Qilin Gu, Raquel Araujo-Gutierrez, Sandeep Kumar, Qing Yan, Felicidad Almazan, Keith A Youker, Yingbin Fu, Henry J Pownall, John P Cooke, Yury I Miller, Longhou Fang
Rationale: Angiogenesis improves perfusion to the ischemic tissue following acute vascular obstruction. Angiogenesis in pathophysiological settings reactivates signaling pathways involved in developmental angiogenesis. We showed previously that apoA-I binding protein (AIBP)-regulated cholesterol efflux in endothelial cells (ECs) controls zebrafish embryonic angiogenesis. Objective: This study is to determine whether loss of AIBP affects angiogenesis in mice during development and under pathological conditions, and to explore the underlying molecular mechanism...
March 21, 2017: Circulation Research
https://www.readbyqxmd.com/read/28316104/implantable-cardioverter-defibrillators-for-primary-prevention-of-mortality-in-patients-with-non-ischemic-cardiomyopathy-a-meta-analysis-of-randomized-controlled-trials
#2
Stavros Stavrakis, Zain Asad, Dwight Reynolds
BACKGROUND: Implantable cardioverter defibrillators (ICDs) improve survival in patients with heart failure due to ischemic cardiomyopathy, but their benefit in non-ischemic cardiomyopathy (NICM) has been recently questioned. We performed a meta-analysis of randomized clinical trials to examine the effect of ICDs on total mortality and arrhythmic death in patients with NICM. We also examined the impact of age and cardiac resynchronization therapy (CRT) on the relative effect of ICD compared to control...
March 18, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28315985/role-of-cardiovascular-magnetic-resonance-in-acute-and-chronic-ischemic-heart-disease
#3
A Baritussio, A Scatteia, C Bucciarelli-Ducci
Cardiovascular magnetic resonance (CMR) is a multi-parametric, multi-planar, non-invasive imaging technique, which allows accurate determination of biventricular function and precise myocardial tissue characterization in a one-stop-shop technique, free from the use of ionizing radiations. Though CMR has been increasingly applied over the last two decades in every-day clinical practice, its widest application has been in the assessment of ischemic cardiomyopathy.
March 18, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28292197/sudden-death-risk-stratification-in-non-ischemic-dilated-cardiomyopathy-using-old-and-new-tools-a-clinical-challenge
#4
Antonis S Manolis
Risk stratification for sudden cardiac death in non-ischemic dilated cardiomyopathy (NIDCM) remains a clinical challenge. Areas Covered: Currently, left ventricular ejection fraction (LVEF), severity of heart failure symptoms according to NYHA classification, and morphology and duration of the QRS complex guide device management in these patients with implantation of a cardioverter defibrillator (ICD) and/or cardiac resynchronization therapy (CRT) devices. Recently, the results of a randomized trial stirred some controversy regarding the utility of ICD in NIDCM patients, however, a subsequent meta-analysis confirmed prior findings of the survival-prolonging benefit of device therapy...
March 15, 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/28281560/electro-echocardiographic-indices-to-predict-cardiac-resynchronization-therapy-non-response-on-non-ischemic-cardiomyopathy
#5
Ziqing Yu, Xueying Chen, Fei Han, Shengmei Qin, Minghui Li, Yuan Wu, Yangang Su, Junbo Ge
Cardiac resynchronization therapy (CRT) threw lights on heart failure treatment, however, parts of patients showed nonresponse to CRT. Unfortunately, it lacks effective parameters to predict CRT non-response. In present study, we try to seek effective electro-echocardiographic predictors on CRT non-response. This is a retrospective study to review a total of 227 patients of dyssynchronous heart failure underwent CRT implantation. Logistic analysis was performed between CRT responders and CRT non-responders...
March 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28264039/in-vivo-t2-weighted-mri-visualizes-cardiac-lesions-in-murine-models-of-acute-and-chronic-viral-myocarditis
#6
Xavier Helluy, Martina Sauter, Yu-Xiang Ye, Gunthard Lykowsky, Jakob Kreutner, Ali Yilmaz, Roland Jahns, Valerie Boivin, Reinhard Kandolf, Peter M Jakob, Karl-Heinz Hiller, Karin Klingel
OBJECTIVE: Acute and chronic forms of myocarditis are mainly induced by virus infections. As a consequence of myocardial damage and inflammation dilated cardiomyopathy and chronic heart failure may develop. The gold standard for the diagnosis of myocarditis is endomyocardial biopsies which are required to determine the etiopathogenesis of cardiac inflammatory processes. However, new non-invasive MRI techniques hold great potential in visualizing cardiac non-ischemic inflammatory lesions at high spatial resolution, which could improve the investigation of the pathophysiology of viral myocarditis...
2017: PloS One
https://www.readbyqxmd.com/read/28262437/myocardial-fibrosis-predicts-ventricular-tachyarrhythmias
#7
REVIEW
Marcello Disertori, Michela Masè, Flavia Ravelli
Myocardial fibrosis is a common pattern in the setting of different heart diseases, and promotes ventricular tachyarrhythmias by creating a vulnerable substrate for reentrant activity and by favoring the emergence of triggers. Currently, late gadolinium enhancement (LGE) cardiac magnetic resonance is considered the reference method for the noninvasive assessment of ventricular fibrosis. Several studies and meta-analyses have shown that ventricular fibrosis detected by LGE is a powerful predictor of ventricular tachyarrhythmic events in ischemic, non-ischemic dilated cardiomyopathy and hypertrophic cardiomyopathy patients...
February 2, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28261285/comparison-of-echocardiography-with-tissue-doppler-imaging-and-magnetic-resonance-imaging-with-delayed-enhancement-in-the-assessment-of-children-with-hypertrophic-cardiomyopathy
#8
Lidia Ziółkowska, Joanna Petryka, Agnieszka Boruc, Wanda Kawalec
INTRODUCTION: In children with hypertrophic cardiomyopathy (HCM) there often occurs a non-ischemic pattern of myocardial fibrosis, which could be the cause of impaired left ventricular (LV) diastolic function assessed by tissue Doppler imaging (TDI). The aim of the study was to determine the prevalence of myocardial fibrosis in children with HCM, and to evaluate its relationship with echocardiographic parameters including LV diastolic dysfunction. MATERIAL AND METHODS: Sixty-three children with HCM, mean age 12...
March 1, 2017: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/28256321/trimetazidine-in-conditions-other-than-coronary-disease-old-drug-new-tricks
#9
REVIEW
Hai Zou, Xing-Xing Zhu, Ya-Hui Ding, Qin-Yang Jin, Lin-Yan Qian, Dong-Sheng Huang, Xue-Jiang Cen
Trimetazidine (TMZ) has traditionally been used as an anti-ischemic drug for coronary artery disease by selectively inhibiting the mitochondrial long-chain 3-ketoacyl-CoA thiolase. Recently, new applications for this therapy have been investigated. This article reviews alternative uses for TMZ in non-coronary artery diseases, such as non-ischemic cardiomyopathy, sepsis, myocardial dysfunction induced by anti-cancer drugs, diabetic cardiomyopathy and contrast-induced nephropathy.
May 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28251724/temporal-trends-over-a-decade-of-defibrillator-therapy-for-primary-prevention-in-community-practice
#10
Serge Boveda, Kumar Narayanan, Sophie Jacob, Rui Providencia, Frankie Beganton, Vincent Algalarrondo, Pascal Defaye, Marie-Cécile Perier, Nicolas Sadoul, Olivier Piot, Didier Klug, Daniel Gras, Laurent Fauchier, Pierre Bordachar, Dominique Babuty, Jean-Claude Deharo, Christophe Leclercq, Eloi Marijon
BACKGROUND: Technology and clinical practice surrounding the use of the primary prevention implantable cardioverter defibrillator (ICD) are in a state of constant evolution. The purpose of the study was to test the hypothesis of significant temporal trends in characteristics and outcomes over a decade of ICD therapy. METHODS: Between 2002-2012, 5,539 consecutive patients (age 62.5±11 years, 84.9% male), with ischemic or non-ischemic cardiomyopathy, implanted with a primary prevention ICD from 12 centers in France were included...
March 2, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28240517/pattern-of-initiation-of-monomorphic-ventricular-tachycardia-and-implications-on-tachycardia-mechanism
#11
Rodrigo S Barbosa, Leon Glass, Riccardo Proietti, Barry Burstein, Lyndon Sobolik, Zhubo D Zhang, Guillaume Viart, Alvin Shrier, Vidal Essebag
The incidence of sudden cardiac death, predominantly caused by ventricular tachycardia and ventricular fibrillation, is high in patients with congestive heart failure. Implantable cardiac defibrillators have improved survival in this population but defibrillator shocks can lead to low quality of life and heart failure progression. The current management of recurrent ventricular tachycardia includes ablation and anti-arrhythmic drugs and both are associated with high recurrence rates. Better understanding the mechanism of ventricular tachycardia allowing individualization of treatment may improve outcomes...
February 27, 2017: Minerva Cardioangiologica
https://www.readbyqxmd.com/read/28220947/does-anyone-really-believe-the-results-of-the-danish-trial-implanting-an-icd-in-non-ischemic-cardiomyopathy-patients
#12
EDITORIAL
J Rod Gimbel, Judith Mackall
The recent publication of the DANISH Trial seems to leave clinicians and patients at a point of therapeutic equipoise regarding the implantation of an ICD in patients with non-ischemic cardiomyopathy. Limitations of the DANISH Trial are discussed and suggestions for a potential way forward are outlined in this controversial area of patient care. This article is protected by copyright. All rights reserved.
February 21, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/28220942/crt-induced-ventricular-tachyarrhythmia-what-s-the-mechanism
#13
Sanoj Chacko, Enes Gul, Chris Simpson, Adrian Baranchuk
A 56-year-old woman with non-ischemic dilated cardiomyopathy and severe left ventricular systolic dysfunction received cardiac resynchronization defibrillator therapy (CRT-D; St Jude Medical Quadra Assura, CA, USA), for primary prevention and management of heart failure. This article is protected by copyright. All rights reserved.
February 21, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/28213903/specifics-of-fetuin-a-levels-in-distinct-types-of-chronic-heart-failure
#14
Michael Lichtenauer, Bernhard Wernly, Vera Paar, Ilonka Rohm, Christian Jung, Atilla Yilmaz, Uta C Hoppe, Paul Christian Schulze, Daniel Kretzschmar, Rudin Pistulli
INTRODUCTION: Fetuin-A has been described to correlate inversely with vascular calcification both in animal models but also in patients with heart and renal disease. In this current study, we sought to investigate whether fetuin-A might be a useful marker for the discrimination of ischemic (ICM) from dilated cardiomyopathy (DCM). METHODS: A total of 124 non-consecutive patients were included in this study, 59 patients suffered from ICM and 65 patients from DCM. Serum samples were obtained during out-patient visits and analyzed for fetuin-A by ELISA...
February 18, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28210871/repeated-doses-of-cardiac-mesenchymal-cells-are-therapeutically-superior-to-a-single-dose-in-mice-with-old-myocardial-infarction
#15
Yiru Guo, Marcin Wysoczynski, Yibing Nong, Alex Tomlin, Xiaoping Zhu, Anna M Gumpert, Marjan Nasr, Senthikumar Muthusamy, Hong Li, Michael Book, Abdur Khan, Kyung U Hong, Qianhong Li, Roberto Bolli
We have recently demonstrated that repeated administrations of c-kit(POS) cardiac progenitor cells (CPCs) have cumulative beneficial effects in rats with old myocardial infarction (MI), resulting in markedly greater improvement in left ventricular (LV) function compared with a single administration. To determine whether this paradigm applies to other species and cell types, mice with a 3-week-old MI received one or three doses of cardiac mesenchymal cells (CMCs), a novel cell type that we have recently described...
March 2017: Basic Research in Cardiology
https://www.readbyqxmd.com/read/28197282/fragmented-qrs-as-a-marker-of-electrical-dyssynchrony-to-predict-inter-ventricular-conduction-defect-by-subsequent-echocardiographic-assessment-in-symptomatic-patients-of-non-ischemic-dilated-cardiomyopathy
#16
Santosh Kumar Sinha, Kush Bhagat, Mohammad Asif, Karandeep Singh, Mohit Sachan, Vikas Mishra, Nasar Afdaali, Mukesh Jitendra Jha, Ashutosh Kumar, Shravan Singh, Rupesh Sinha, Dibbendhu Khanra, Ramesh Thakur, Chandra Mohan Varma, Vinay Krishna, Umeshwar Pandey
BACKGROUND: Left ventricular (LV) dyssynchrony frequently occurs in patients with heart failure (HF). QRS ≥ 120 ms is a surrogate marker of electrical dyssynchrony, which occurs in only 30% of HF patients. In contrary, in those with normal QRS (nQRS) duration, LV dyssynchrony has been reported in 20-50%. This study was carried out to investigate the role of fragmented QRS (fQRS) on the surface electrocardiography (ECG) as a marker of electrical dyssynchrony to predict the presence of significant intraventricular dyssynchrony (IVD) by subsequent echocardiographic assessment...
August 2016: Cardiology Research
https://www.readbyqxmd.com/read/28194727/review-of-cardiovascular-imaging-in-the-journal-of-nuclear-cardiology-in-2016-part-1-of-2-positron-emission-tomography-computed-tomography-and-magnetic-resonance
#17
Wael AlJaroudi, Fadi G Hage
Several original articles and editorials have been published in the Journal of Nuclear Cardiology last year. It has become a tradition at the beginning of each year to summarize some of these key articles (AlJaroudi and Hage in J Nucl Cardiol 22:507-512, 2015, 23:122-130, 2016; Hage and AlJaroudi in J Nucl Cardiol 22:714-719, 2015; 23:493-498, 2016). In this part one, we will discuss some of the progress made in patients with infiltrative disease, cardiomyopathies (non-ischemic, ischemic, and diabetic), hybrid and molecular imaging, using advancement in positron emission tomography, computed tomography, and magnetic resonance imaging...
February 13, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28176398/the-relationship-of-antitachycardia-pacing-versus-shock-in-an-implantable-cardioverter-defibrillator-population-and-the-risk-of-mortality-just-an-association
#18
EDITORIAL
Jonathan C Hsu, Kurt S Hoffmayer
No abstract text is available yet for this article.
February 8, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28154594/effectiveness-of-implantable-cardioverter-defibrillator-therapy-for-heart-failure-patients-according-to-ischemic-or-non-ischemic-etiology-in-korea
#19
Kyu-Hwan Park, Chan-Hee Lee, Byung Chun Jung, Yongkeun Cho, Myung Hwan Bae, Yoon-Nyun Kim, Hyoung-Seob Park, Seongwook Han, Young Soo Lee, Dae-Woo Hyun, Jun Kim, Dae Kyeong Kim, Tae-Jun Cha, Dong-Gu Shin
BACKGROUND AND OBJECTIVES: This study was performed to describe clinical characteristics of patients with left ventriculars (LV) dysfunction and implantable cardioverter-defibrillator (ICD), and to evaluate the effect of ICD therapy on survival in Yeongnam province of Korea. SUBJECTS AND METHODS: From a community-based device registry (9 centers, Yeongnam province, from November 1999 to September 2012), 146 patients with LV dysfunction and an ICD implanted for primary or secondary prophylaxis, were analyzed...
January 2017: Korean Circulation Journal
https://www.readbyqxmd.com/read/28154101/cardioembolic-stroke
#20
Hooman Kamel, Jeff S Healey
Cardiac embolism accounts for an increasing proportion of ischemic strokes and might multiply several-fold during the next decades. However, research points to several potential strategies to stem this expected rise in cardioembolic stroke. First, although one-third of strokes are of unclear cause, it is increasingly accepted that many of these cryptogenic strokes arise from a distant embolism rather than in situ cerebrovascular disease, leading to the recent formulation of embolic stroke of undetermined source as a distinct target for investigation...
February 3, 2017: Circulation Research
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