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Non ischemic cardiomyopathy

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https://www.readbyqxmd.com/read/27925329/fragmented-qrs-is-a-novel-risk-factor-for-ventricular-arrhythmic-events-after-receiving-cardiac-resynchronization-therapy-in-non-ischemic-cardiomyopathy
#1
Miyako Igarashi, Hiroshi Tada, Hiro Yamasaki, Kenji Kuroki, Tomoko Ishizu, Yoshihiro Seo, Takeshi Machino, Nobuyuki Murakoshi, Yukio Sekiguchi, Yuichi Noguchi, Akihiko Nogami, Kazutaka Aonuma
INTRODUCTION: A fragmented QRS (fQRS) is reported to be associated with a poor prognosis or sudden cardiac death (SCD) in patients with Brugada syndrome or ischemic heart disease. However, no studies have clarified the impact of the presence of an fQRS on SCD or ventricular arrhythmic events in patients receiving cardiac resynchronization therapy (CRT). This study aimed to clarify this point in patients with non-ischemic cardiomyopathy. METHODS AND RESULTS: This study included 137 heart failure patients with non-ischemic cardiomyopathy who received CRT (NYHA functional class: II/III/IV = 25/84/28)...
December 7, 2016: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/27909478/cardiac-resynchronization-therapy-in-non-ischemic-cardiomyopathy
#2
REVIEW
Miriam Shanks Md PhD, Victoria Delgado Md PhD, Jeroen J Bax Md PhD
Cardiac resynchronization therapy (CRT) is an established therapy for heart failure patients who remain symptomatic despite optimal medical therapy, have reduced left ventricular ejection fraction (<35%) and wide QRS duration (>120 ms), preferably with left bundle branch block morphology. The response to CRT depends on the cardiac substrate: presence of correctable left ventricular mechanical dyssynchrony, presence of myocardial fibrosis (scar) and position of the left ventricular pacing lead. Patients with non-ischemic cardiomyopathy have shown higher response rates to CRT compared with patients with ischemic cardiomyopathy...
February 2016: Journal of Atrial Fibrillation
https://www.readbyqxmd.com/read/27905927/characteristics-and-outcomes-of-diabetic-patients-with-an-implantable-cardioverter-defibrillator-in-a-real-world-setting-results-from-the-israeli-icd-registry
#3
Hillel Steiner, Michael Geist, Ilan Goldenberg, Mahmoud Suleiman, Michael Glikson, Alexander Tenenbaum, Moshe Swissa, Enrique Z Fisman, Gregory Golovchiner, Boris Strasberg, Alon Barsheshet
AIMS: There are limited data regarding the effect of diabetes mellitus (DM) on the risks of both appropriate and inappropriate implantable cardioverter defibrillator (ICD) therapy. The present study was designed to compare the outcome of appropriate and inappropriate ICD therapy in patients with or without DM. METHODS AND RESULTS: The risk of a first appropriate ICD therapy for ventricular tachyarrhythmias (including anti tachycardia pacing and shock) was compared between 764 DM and 1346 non-DM patients enrolled in the national Israeli ICD registry...
December 1, 2016: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/27903393/-a-multi-center-study-on-the-long-term-mortality-and-related-risk-factors-in-patients-with-chronic-heart-failure-receiving-resynchronization-therapy
#4
S Y Qi, D M Wang, H B Yu, C Ding, F L Tian, L S Ru, J Li, B Zhang, Y L Han
Objective: To analyze long-term mortality and patients characteristics of cardiac resynchronization therapy (CRT) for patients with chronic heart failure. Methods: In-patients with chronic heart failure who received CRT in the three medical centers(Bethune International Peace Hospital, General Hospital of Shenyang Military Command of Chinese People's Liberation Army, and 251 Hospital of People's Liberation Army)from March 2001 to June 2013 were included.Mortality and related causes, echocardiographic parameters were analyzed...
November 24, 2016: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/27903390/-current-status-of-antiarrhythmic-drug-use-and-safety-assessment-in-chinese-patients-with-atrial-fibrillation
#5
R He, X Du, S W Liu, L J Sun, Y Li, H Zeng, Y Y Li, C Sun, Y Zhang, C S Ma, W Gao
Objective: To investigate the current status of antiarrhythmic drugs (AADs) use in Chinese patients with atrial fibrillation(AF) and assess the safety of AADs in this patient cohort. Methods: From January 2011 to December 2013, a total of 4 008 AF patients treated with AADs was enrolled in this study and patients were followed up for 24 months. Detailed information of prescribed drug, the causes of drug discontinuation and side effects were recorded. Results: Amiodarone was prescribed to 64.3%(2 579 cases) and propafenone to 31...
November 24, 2016: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/27884156/targeted-myocardial-gene-expression-in-failing-hearts-by-rna-sequencing
#6
Kajari Dhar, Alexandra M Moulton, Eric Rome, Fang Qiu, Jeff Kittrell, Eugenia Raichlin, Ronald Zolty, John Y Um, Michael J Moulton, Hesham Basma, Daniel R Anderson, James D Eudy, Brian D Lowes
BACKGROUND: Myocardial recovery with left ventricular assist device (LVAD) therapy is highly variable and difficult to predict. Next generation ribonucleic acid (RNA) sequencing is an innovative, rapid, and quantitative approach to gene expression profiling in small amounts of tissue. Our primary goal was to identify baseline transcriptional profiles in non-ischemic cardiomyopathies that predict myocardial recovery in response to LVAD therapy. We also sought to verify transcriptional differences between failing and non-failing human hearts...
November 25, 2016: Journal of Translational Medicine
https://www.readbyqxmd.com/read/27873128/assessment-of-myocardial-delayed-enhancement-with-cardiac-computed-tomography-in-cardiomyopathies-a-prospective-comparison-with-delayed-enhancement-cardiac-magnetic-resonance-imaging
#7
Hye-Jeong Lee, Dong Jin Im, Jong-Chan Youn, Suyon Chang, Young Joo Suh, Yoo Jin Hong, Young Jin Kim, Jin Hur, Byoung Wook Choi
To evaluate the feasibility of cardiac CT for the evaluation of myocardial delayed enhancement (MDE) in the assessment of patients with cardiomyopathy, compared to cardiac MRI. A total of 37 patients (mean age 54.9 ± 15.7 years, 24 men) who underwent cardiac MRI to evaluate cardiomyopathy were enrolled. Dual-energy ECG-gated cardiac CT was acquired 12 min after contrast injection. Two observers evaluated cardiac MRI and cardiac CT at different kV settings (100, 120 and 140 kV) independently for MDE pattern-classification (patchy, transmural, subendocardial, epicardial and mesocardial), differentiation between ischemic and non-ischemic cardiomyopathy and MDE quantification (percentage MDE)...
November 22, 2016: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/27866869/clinical-characteristics-and-outcomes-of-yemeni-patients-with-acute-heart-failure-aged-50years-or-younger-data-from-gulf-acute-heart-failure-registry-gulf-care
#8
A-Nasser Munibari, Ahmed Al-Motarreb, Nora Al-Sagheer, Hana Abu Hadi, Ali Othman, Nawar Al-Wather, Abdu Hamoud, Mutae Alawlagy, Salem Almehdar, Abdulkarim Alhammadi, Mohammed Almogayed, Giorgio Caretta, Anees Al Jabri, Luciano Agati
AIMS: There is a shortage of data about acute heart failure (AHF) in the young, including its underlying causes, clinical presentation and outcomes. We aim to describe clinical characteristics, causes and outcomes of AHF in Yemeni patients aged 50years or younger. METHODS AND RESULTS: we evaluated Yemeni patients with AHF enrolled in Gulf CARE registry. Patients were divided into two groups: young patients (≤50years) and older patients (>50years). A total of 1536 patients with AHF were enrolled, of whom 635 (41...
November 9, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27863359/is-hyperhomocysteinemia-a-causal-factor-for-heart-failure-the-impact-of-the-functional-variants-of-mthfr-and-pon1-on-ischemic-and-non-ischemic-etiology
#9
Ewa Strauss, Wieslaw Supinski, Artur Radziemski, Grzegorz Oszkinis, Andrzej Leon Pawlak, Jerzy Gluszek
BACKGROUND: Hyperhomocysteinemia was found to be uniformly associated with the development of heart failure (HF) and HF mortality; however, it is uncertain whether this relation is causative or not. We used Mendelian randomization to examine the associations of the methylene tetrahydrofolate gene (MTHFR) and paraoxonase 1 gene (PON1) variants as a proxy for lifelong exposure to high Hcy and Hcy-thiolactone concentrations with the development of HF in men aged ≤60years and the occurrence of adverse effects at one-year follow-up...
November 9, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27860063/a-comparison-of-women-and-men-undergoing-catheter-ablation-for-sustained-monomorphic-ventricular-tachycardia
#10
Samuel H Baldinger, Saurabh Kumar, Jorge Romero, Akira Fujii, Laurence M Epstein, Gregory F Michaud, Roy John, Usha B Tedrow, William G Stevenson
INTRODUCTION: Women are underrepresented in clinical studies on catheter ablation (CA) for ventricular tachycardia (VT). The role of gender as a predictor for VT recurrence after CA is unclear and complication rates have not been compared in a large cohort. METHODS AND RESULTS: We analyzed data of consecutive patients undergoing CA for sustained monomorphic VT at our center between 2005 and 2015. A total of 948 patients underwent 1314 ablation procedures: 114 patients without SHD (48% female), 486 with coronary artery disease (CAD) (9% female), 301 with non-ischemic cardiomyopathy (NICM) (22% female), and 46 with arrhythmogenic right ventricular cardiomyopathy (ARVC) (17% female)...
November 18, 2016: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/27858926/-heart-failure-role-of-cardiovascular-imaging
#11
Rienzi Díaz Navarro
The usefulness of echocardiography and the new noninvasive cardiac techniques in assessing heart failure is analyzed. The usefulness of non-invasive CT coronary angiography, as well as the growing applications of magnetic resonance imaging (MRI) in the study of ischemic heart disease, cardiomyopathy and arrhythmogenic right ventricular dysplasia is considered. For this puspose, some clinical cases are used. The combined use of these techniques, especially in patients in whom the etiology of heart failure is ischemic heart disease or cardiomyopathy is emphasized...
October 11, 2016: Medwave
https://www.readbyqxmd.com/read/27856539/left-ventricular-dimensions-predict-risk-of-appropriate-shocks-but-not-mortality-in-cardiac-resynchronization-therapy-defibrillator-recipients-with-left-bundle-branch-block-and-non-ischemic-cardiomyopathy
#12
Evan C Adelstein, David Schwartzman, Sandeep Jain, Raveen Bazaz, Norman C Wang, Samir Saba
AIMS: Patients with non-ischaemic cardiomyopathy (NICM) and left bundle-branch block (LBBB) often benefit markedly from cardiac resynchronization therapy (CRT). Cardiac resynchronization therapy responders have a lower risk of appropriate device shocks from CRT-defibrillators (CRT-D) than do non-responders. Larger baseline left ventricular (LV) dimensions may be associated with less CRT response and thus greater risk of appropriate shocks. METHODS AND RESULTS: We analysed all (n = 249; 55% female) primary prevention CRT-D recipients at our institution with LBBB, NICM, and measured LV dimensions prior to device implant for the outcomes of (i) appropriate shocks, (ii) any appropriate tachyarrhythmia therapies, and (iii) risk of death, transplant, or left ventricular assist device (LVAD)...
November 17, 2016: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/27856497/intravenous-allogeneic-mesenchymal-stem-cells-for-non-ischemic-cardiomyopathy-safety-and-efficacy-results-of-a-phase-ii-a-randomized-trial
#13
Javed Butler, Stephen E Epstein, Stephen J Greene, Arshed A Quyyumi, Sergey Sikora, Raymond J Kim, Allen S Anderson, Jane E Wilcox, Nikolai I Tankovich, Michael J Lipinski, Yi-An Ko, Kenneth B Margulies, Robert T Cole, Hal A Skopicki, Mihai Gheorghiade
RATIONALE: Potential benefits of mesenchymal stem cell (MSC) therapy in heart failure (HF) may be related to paracrine properties and systemic effects, including anti-inflammatory activities. If this hypothesis is valid, intravenous administration of MSCs should improve outcomes in HF, an entity in which excessive chronic inflammation may play a pivotal role. OBJECTIVE: To assess the safety and preliminary efficacy of intravenously administered ischemia tolerant MSCs (itMSCs) in patients with non-ischemic cardiomyopathy...
November 16, 2016: Circulation Research
https://www.readbyqxmd.com/read/27856208/randomized-comparison-of-allogeneic-vs-autologous-mesenchymal-stem-cells-for-non-lschemic-dilated-cardiomyopathy-poseidon-dcm-trial
#14
Joshua M Hare, Darcy L DiFede, Angela M Castellanos, Victoria Florea, Ana M Landin, Jill El-Khorazaty, Aisha Khan, Muzammil Mushtaq, Maureen H Lowery, John J Byrnes, Robert C Hendel, Mauricio G Cohen, Carlos E Alfonso, Krystalenia Valasaki, Marietsy V Pujol, Samuel Golpanian, Eduard Ghersin, Joel E Fishman, Pradip Pattany, Samirah A Gomes, Cindy Delgado, Roberto Miki, Fouad Abuzeid, Mayra Vidro-Casiano, Courtney Premer, Audrey Medina, Valeria Porras, Konstantinos E Hatzistergos, Erica Anderson, Adam Mendizabal, Raul Mitrani, Alan W Heldman
BACKGROUND: While human mesenchymal stem cells (hMSCs) have been tested in ischemic cardiomyopathy, few studies exist in chronic non-ischemic dilated cardiomyopathy (NIDCM). OBJECTIVES: The POSEIDON-DCM trial is a randomized comparison of safety and efficacy of autologous (auto) vs. allogeneic (allo) bone marrow-derived hMSCs in NIDCM. METHODS: Thirty-seven patients were randomized to either allo- or auto-hMSCs in a 1:1 ratio. Patients were recruited between December 2011 and July 2015 at the University of Miami Hospital...
November 14, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27846845/relationship-between-native-papillary-muscle-t1-time-and-severity-of-functional-mitral-regurgitation-in-patients-with-non-ischemic-dilated-cardiomyopathy
#15
Shingo Kato, Shiro Nakamori, Sébastien Roujol, Francesca N Delling, Shadi Akhtari, Jihye Jang, Tamer Basha, Sophie Berg, Kraig V Kissinger, Beth Goddu, Warren J Manning, Reza Nezafat
BACKGROUND: Functional mitral regurgitation is one of the severe complications of non-ischemic dilated cardiomyopathy (DCM). Non-contrast native T1 mapping has emerged as a non-invasive method to evaluate myocardial fibrosis. We sought to evaluate the potential relationship between papillary muscle T1 time and mitral regurgitation in DCM patients. METHODS: Forty DCM patients (55 ± 13 years) and 20 healthy adult control subjects (54 ± 13 years) were studied...
November 16, 2016: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/27832063/one-health-interactions-of-chagas-disease-vectors-canid-hosts-and-human-residents-along-the-texas-mexico-border
#16
Melissa N Garcia, Sarah O'Day, Susan Fisher-Hoch, Rodion Gorchakov, Ramiro Patino, Teresa P Feria Arroyo, Susan T Laing, Job E Lopez, Alexandra Ingber, Kathryn M Jones, Kristy O Murray
BACKGROUND: Chagas disease (Trypanosoma cruzi infection) is the leading cause of non-ischemic dilated cardiomyopathy in Latin America. Texas, particularly the southern region, has compounding factors that could contribute to T. cruzi transmission; however, epidemiologic studies are lacking. The aim of this study was to ascertain the prevalence of T. cruzi in three different mammalian species (coyotes, stray domestic dogs, and humans) and vectors (Triatoma species) to understand the burden of Chagas disease among sylvatic, peridomestic, and domestic cycles...
November 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27821538/cardiac-mortality-among-200%C3%A2-000-five-year-survivors-of-cancer-diagnosed-at-15-to-39-years-of-age-the-teenage-and-young-adult-cancer-survivor-study
#17
Katherine E Henson, Raoul C Reulen, David L Winter, Chloe J Bright, Miranda M Fidler, Clare Frobisher, Joyeeta Guha, Kwok F Wong, Julie Kelly, Angela B Edgar, Martin G McCabe, Jeremy Whelan, David J Cutter, Sarah C Darby, Mike M Hawkins
BACKGROUND: Survivors of teenage and young adult cancer are acknowledged as understudied. Little is known about their long-term adverse health risks, particularly of cardiac disease that is increased in other cancer populations where cardiotoxic treatments have been used. METHODS: The Teenage and Young Adult Cancer Survivor Study cohort comprises 200 945 5-year survivors of cancer diagnosed at 15 to 39 years of age in England and Wales from 1971 to 2006, and followed to 2014...
November 15, 2016: Circulation
https://www.readbyqxmd.com/read/27818482/high-dose-%C3%AE-blocker-therapy-triggers-additional-reverse-remodeling-in-patients-with-idiopathic-non-ischemic-cardiomyopathy
#18
Daisuke Nitta, Koichiro Kinugawa, Teruhiko Imamura, Naoko P Kato, Issei Komuro
Carvedilol has established its evidence to improve prognosis and facilitate left ventricular reverse remodeling (LVRR) in heart failure patients with reduced left ventricular ejection fraction (LVEF), and many studies have supported its dose-dependency. However, there are few studies demonstrating the effect of high dose carvedilol in Japan. We enrolled 23 patients with idiopathic non-ischemic cardiomyopathy, in whom LVEF remained 45% or less despite 20 mg/ day of carvedilol therapy for > 3 months. After high dose (40 mg/day) carvedilol therapy for > 3 months, LVEF improved (+9...
November 4, 2016: International Heart Journal
https://www.readbyqxmd.com/read/27804074/mechanical-dyssynchrony-according-to-validated-cut-off-values-using-gated-spect-myocardial-perfusion-imaging
#19
Santiago Aguadé-Bruix, Guillermo Romero-Farina, Jaume Candell-Riera, María N Pizzi, David García-Dorado
BACKGROUND: The aim of this study was to establish different degrees of mechanical dyssynchrony according to validated cut-off (CO) values of myocardial perfusion gated SPECT phase analysis parameters (SD, standard deviation; B, bandwidth; S, skewness; K, kurtosis). METHODS: Using Emory Cardiac Toolbox™, we prospectively analyzed 408 patients (mean age 64.1 years, 26.7% female), divided into a control group of 150 normal subjects and a validation group of 258 patients (left bundle branch block: 17...
November 1, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/27785679/the-evaluation-of-non-ischemic-dilated-cardiomyopathy-with-t1-mapping-and-ecv-methods-using-3t-cardiac-mri
#20
Cemile Ayşe Görmeli, Zeynep Maraş Özdemir, Ayşegül Sağır Kahraman, Jülide Yağmur, Ramazan Özdemir, Cemil Çolak
PURPOSE: The aim of this study was to examine the correlation between ventricular function and the extracellular volume fraction (ECV) in patients with non-ischemic dilated cardiomyopathy (NIDCM) using 3.0 T magnetic resonance imaging (MRI). We also hypothesized that native T1 and ECV values would be increased in patients with NIDCM, independent of the left ventricular ejection fraction (LVEF). The findings of our study could lead to further studies of the follow-up protocols. MATERIALS AND METHODS: In total, 53 consecutive dilated cardiomyopathy patients who had undergone cardiac MRI were functionally evaluated and underwent tissue characterization...
October 27, 2016: La Radiologia Medica
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