Feiven Fan, Franz E Babl, Ella E K Swaney, Stephen J C Hearps, Michael Takagi, Samantha J Emery-Corbin, Laura F Dagley, Jumana Yousef, Georgia M Parkin, Vanessa C Rausa, Nicholas Anderson, Fabian Fabiano, Kevin Dunne, Marc Seal, Gavin A Davis, Chantal Attard, Vicki Anderson, Vera Ignjatovic
OBJECTIVE: Posttraumatic headache (PTH) represents the most common acute and persistent symptom in children after concussion, yet there is no blood protein signature to stratify the risk of PTH after concussion to facilitate early intervention. This discovery study aimed to identify capillary blood protein markers, at emergency department (ED) presentation within 48 hours of concussion, to predict children at risk of persisting PTH at 2 weeks postinjury. METHODS: Capillary blood was collected using the Mitra Clamshell device from children aged 8-17 years who presented to the ED of the Royal Children's Hospital, Melbourne, Australia, within 48 hours of sustaining a concussion...
March 8, 2024: Journal of Neurosurgery. Pediatrics