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https://www.readbyqxmd.com/read/27814886/duration-of-untreated-illness-in-first-treatment-bipolar-i-disorder-in-relation-to-clinical-outcome-and-cannabis-use
#1
Levi Røstad Kvitland, Petter Andreas Ringen, Sofie Ragnhild Aminoff, Christine Demmo, Tone Hellvin, Trine Vik Lagerberg, Ole Andreas Andreassen, Ingrid Melle
There is little knowledge about the role of the duration of untreated bipolar (DUB) illness in first-treatment bipolar disorder I (BD I), its association with symptoms at start of first treatment, and development over the first year, and limited knowledge about factors that influence the length of DUB. Substance use has shown to delay identification of primary psychiatric disorders, and while cannabis use is common in BD the role of cannabis in relationship to DUB is unclear. The aim of the present study is to examine the associations between DUB and key clinical outcomes at baseline in BD I, and at one year follow-up, and to evaluate the influence of cannabis use...
October 28, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/27742912/disruptive-mood-dysregulation-disorder-severe-mood-dysregulation-and-chronic-irritability-in-youth-at-high-familial-risk-of-bipolar-disorder
#2
Tania Perich, Andrew Frankland, Gloria Roberts, Florence Levy, Rhoshel Lenroot, Philip B Mitchell
OBJECTIVE: Disruptive mood dysregulation disorder is a newly proposed childhood disorder included in Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition to describe children ⩽18 years of age with chronic irritability/temper outbursts. This study aimed to examine the prevalence of disruptive mood dysregulation disorder, severe mood dysregulation and chronic irritability in an Australian study of young people at increased familial risk of developing bipolar disorder ('HR' group) and controls ('CON' group)...
October 14, 2016: Australian and New Zealand Journal of Psychiatry
https://www.readbyqxmd.com/read/27536368/accuracy-of-2012-international-consensus-guidelines-for-the-prediction-of-malignancy-of-branch-duct-intraductal-papillary-mucinous-neoplasms-of-the-pancreas
#3
Enrique Pérez-Cuadrado Robles, Frédérique Maire, Jérôme Cros, Marie-Pierre Vullierme, Vinciane Rebours, Alain Sauvanet, Alain Aubert, Safi Dokmak, Philippe Lévy, Philippe Ruszniewski
OBJECTIVE: To determine accuracy of 2012 International Consensus Guidelines (ICG) predicting malignancy in a surgical cohort of branch-duct intraductal papillary mucinous neoplasms (BD-IPMN). METHODS: This study included all consecutive patients with final pathological diagnosis of pure BD-IPMN resected between 2006 and 2014 at Beaujon Hospital. Neoplasms were classified as malignant in presence of high-grade dysplasia (HGD) or invasive carcinoma. Medical, pathological, and radiological data were retrospectively recorded...
August 2016: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/27334286/severe-mental-illness-and-acute-stress-a-study-of-service-utilization-in-a-conflict-zone
#4
Demian Halperin, Tal Levy, Sofia Avissar, Gabriel Schreiber
Patients suffering from severe mental illness (SMI) are considered especially vulnerable to stress. In this study, their use of acute stress services in a military context affecting civilian populations was assessed, using naturally occurring data. The proportion of patients with a previously known SMI, defined as any chronic psychotic disorder or bipolar disorder, among all civilians examined at a center for treatment of stress during a military conflict versus at the ER in usual times, was compared, using the Chi square statistical test...
June 22, 2016: Psychiatric Quarterly
https://www.readbyqxmd.com/read/27291060/interhemispheric-white-matter-integrity-in-young-people-with-bipolar-disorder-and-at-high-genetic-risk
#5
G Roberts, W Wen, A Frankland, T Perich, E Holmes-Preston, F Levy, R K Lenroot, D Hadzi-Pavlovic, J I Nurnberger, M Breakspear, P B Mitchell
BACKGROUND: White matter (WM) impairments have been reported in patients with bipolar disorder (BD) and those at high familial risk of developing BD. However, the distribution of these impairments has not been well characterized. Few studies have examined WM integrity in young people early in the course of illness and in individuals at familial risk who have not yet passed the peak age of onset. METHOD: WM integrity was examined in 63 BD subjects, 150 high-risk (HR) individuals and 111 participants with no family history of mental illness (CON)...
August 2016: Psychological Medicine
https://www.readbyqxmd.com/read/27120077/exome-sequencing-of-familial-bipolar-disorder
#6
Fernando S Goes, Mehdi Pirooznia, Jennifer S Parla, Melissa Kramer, Elena Ghiban, Senem Mavruk, Yun-Ching Chen, Eric T Monson, Virginia L Willour, Rachel Karchin, Matthew Flickinger, Adam E Locke, Shawn E Levy, Laura J Scott, Michael Boehnke, Eli Stahl, Jennifer L Moran, Christina M Hultman, Mikael Landén, Shaun M Purcell, Pamela Sklar, Peter P Zandi, W Richard McCombie, James B Potash
IMPORTANCE: Complex disorders, such as bipolar disorder (BD), likely result from the influence of both common and rare susceptibility alleles. While common variation has been widely studied, rare variant discovery has only recently become feasible with next-generation sequencing. OBJECTIVE: To utilize a combined family-based and case-control approach to exome sequencing in BD using multiplex families as an initial discovery strategy, followed by association testing in a large case-control meta-analysis...
June 1, 2016: JAMA Psychiatry
https://www.readbyqxmd.com/read/27088656/comparison-of-serum-carnitine-levels-and-clinical-correlates-between-outpatients-and-acutely-hospitalised-individuals-with-bipolar-disorder-and-schizophrenia-a-cross-sectional-study
#7
Miroslav Cuturic, Ruth K Abramson, Robert J Breen, Alfred C Edwards, Elliott E Levy
OBJECTIVES: We sought to compare serum carnitine levels and clinical correlates between stable outpatients and acutely hospitalised individuals with diagnoses of bipolar disorder and schizophrenia. METHODS: We obtained clinical information as well as serum levels for total and free carnitine, high-density lipoprotein (HDL) and triglycerides in 60 consenting individuals. RESULTS: We found higher total serum carnitine levels in our outpatient group in comparison to acutely hospitalised psychiatric patients, with a statistically significant P value of 0...
September 2016: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/27067698/abnormalities-in-left-inferior-frontal-gyral-thickness-and-parahippocampal-gyral-volume-in-young-people-at-high-genetic-risk-for-bipolar-disorder
#8
G Roberts, R Lenroot, A Frankland, P K Yeung, N Gale, A Wright, P Lau, F Levy, W Wen, P B Mitchell
BACKGROUND: Fronto-limbic structural brain abnormalities have been reported in patients with bipolar disorder (BD), but findings in individuals at increased genetic risk of developing BD have been inconsistent. We conducted a study in adolescents and young adults (12-30 years) comparing measures of fronto-limbic cortical and subcortical brain structure between individuals at increased familial risk of BD (at risk; AR), subjects with BD and controls (CON). We separately examined cortical volume, thickness and surface area as these have distinct neurodevelopmental origins and thus may reflect differential effects of genetic risk...
July 2016: Psychological Medicine
https://www.readbyqxmd.com/read/26990158/history-of-psychosis-and-previous-episodes-as-potential-explanatory-factors-for-neurocognitive-impairment-in-first-treatment-bipolar-i-disorder
#9
Christine Demmo, Trine Vik Lagerberg, Sofie R Aminoff, Tone Hellvin, Levi R Kvitland, Carmen Simonsen, Ole A Andreassen, Ingrid Melle, Torill Ueland
OBJECTIVES: Explanatory factors for the observed neurocognitive impairment in early-stage bipolar I disorder (BD-I) have received little attention. The current study investigated neurocognitive functioning in first-treatment (FT) BD-I compared to FT schizophrenia (SCZ), and healthy controls (HCs), and the effect of history of psychosis and previous episodes in the two clinical groups. METHODS: A total of 202 FT patients with BD-I (n = 101) and SCZ spectrum disorder (n = 101), in addition to HCs (n = 101), were included...
March 2016: Bipolar Disorders
https://www.readbyqxmd.com/read/26486425/early-exposure-to-parental-bipolar-disorder-and-risk-of-mood-disorder-the-flourish%C3%A2-canadian-prospective-offspring-cohort-study
#10
Sarah Goodday, Adrian Levy, Gordon Flowerdew, Julie Horrocks, Paul Grof, Mark Ellenbogen, Anne Duffy
AIM: Exposure to postnatal parental depression is associated with offspring mood disorder later in life; however, little is known about exposure to parental bipolar disorder (BD) and subsequent risk of psychopathology. The aim of this study was to determine the association between the duration, severity and timing of exposure to parental BD in early childhood and subsequent risk of mood disorder. METHODS: 189 offspring of a parent with BD completed annual assessments following Kiddie Schedule for Affective Disorders (KSADS) format semistructured interviews as part of an ongoing 16-year prospective cohort study...
October 21, 2015: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/26373604/network-dysfunction-of-emotional-and-cognitive-processes-in-those-at-genetic-risk-of-bipolar-disorder
#11
Michael Breakspear, Gloria Roberts, Melissa J Green, Vinh T Nguyen, Andrew Frankland, Florence Levy, Rhoshel Lenroot, Philip B Mitchell
The emotional and cognitive vulnerabilities that precede the development of bipolar disorder are poorly understood. The inferior frontal gyrus-a key cortical hub for the integration of cognitive and emotional processes-exhibits both structural and functional changes in bipolar disorder, and is also functionally impaired in unaffected first-degree relatives, showing diminished engagement during inhibition of threat-related emotional stimuli. We hypothesized that this functional impairment of the inferior frontal gyrus in those at genetic risk of bipolar disorder reflects the dysfunction of broader network dynamics underlying the coordination of emotion perception and cognitive control...
November 2015: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/25740047/genomewide-association-analyses-of-electrophysiological-endophenotypes-for-schizophrenia-and-psychotic-bipolar-disorders-a-preliminary-report
#12
Mei-Hua Hall, Chia-Yen Chen, Bruce M Cohen, Kevin M Spencer, Deborah L Levy, Dost Öngür, Jordan W Smoller
Several event-related potentials (ERP), including P3, sensory gating (P50), and gamma oscillation, are robustly impaired in patients with schizophrenia (SCZ) and bipolar disorder (BIP). Although these ERPs are known to be heritable, little is known about the specific genetic loci involved and the degree to which they overlap with loci influencing mood and psychotic disorders. In the present study, we conducted GWAS to a) identify common variants associated with ERP endophenotypes, and b) construct polygenic risk scores (PRS) to examine overlap between genetic components of ERPs and mood and psychotic disorders...
April 2015: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
https://www.readbyqxmd.com/read/25700556/what-clinical-features-precede-the-onset-of-bipolar-disorder
#13
Tania Perich, Phoebe Lau, Dusan Hadzi-Pavlovic, Gloria Roberts, Andrew Frankland, Adam Wright, Melissa Green, Michael Breakspear, Justine Corry, Basia Radlinska, Clare McCormack, Cassandra Joslyn, Florence Levy, Rhoshel Lenroot, John I Nurnberger Jnr, Philip B Mitchell
Despite a growing number of reports, there is still limited knowledge of the clinical features that precede the onset of bipolar disorder (BD). To explore this, we investigated baseline data from a prospectively evaluated longitudinal cohort of subjects aged 12-30 years to compare: first, lifetime rates of clinical features between a) subjects at increased genetic risk for developing BD ('AR'), b) participants from families without mental illness ('controls'), and c) those with established BD; and, second, prior clinical features that predict the later onset of affective disorders in these same three groups...
March 2015: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/25696783/stigma-social-anxiety-and-illness-severity-in-bipolar-disorder-implications-for-treatment
#14
REVIEW
Boaz Levy, Elena Tsoy, Madeline Brodt, Karen Petrosyan, Mary Malloy
BACKGROUND: Studies indicate that comorbid anxiety disorders predict a more severe course of illness in bipolar disorder (BD). The relatively high prevalence of social anxiety in BD points to the potential role that socio-cultural factors, such as stigma, play in exacerbating the progression of this disorder. Stigma creates social anxiety in affected individuals because it essentially forces them into a vulnerable social status that is marked by public disgrace. Although the etiology of debilitating social anxiety in BD may involve multiple factors, stigma deserves particular clinical attention because research in this area indicates that it is common and its internalization is associated with poor outcome...
February 2015: Annals of Clinical Psychiatry: Official Journal of the American Academy of Clinical Psychiatrists
https://www.readbyqxmd.com/read/25651990/continued-cannabis-use-at-one-year-follow-up-is-associated-with-elevated-mood-and-lower-global-functioning-in-bipolar-i-disorder
#15
Levi Roestad Kvitland, Ingrid Melle, Sofie Ragnhild Aminoff, Christine Demmo, Trine Vik Lagerberg, Ole Andreas Andreassen, Petter Andreas Ringen
BACKGROUND: There is limited knowledge about how environmental factors affect the course of bipolar disorder (BD). Cannabis has been proposed as a potential risk factor for poorer course of illness, but the role of cannabis use has not been studied in a first treatment BD I sample. METHODS: The present study examines the associations between course of illness in first treatment BD I and continued cannabis use, from baseline to one year follow up. Patients (N = 62) with first treatment DSM-IV BD I were included as part of the Thematically Organized Psychosis study (TOP), and completed interviews and self-report questionnaires at both baseline and follow up...
2015: BMC Psychiatry
https://www.readbyqxmd.com/read/25651064/identification-of-a-common-neurobiological-substrate-for-mental-illness
#16
Madeleine Goodkind, Simon B Eickhoff, Desmond J Oathes, Ying Jiang, Andrew Chang, Laura B Jones-Hagata, Brissa N Ortega, Yevgeniya V Zaiko, Erika L Roach, Mayuresh S Korgaonkar, Stuart M Grieve, Isaac Galatzer-Levy, Peter T Fox, Amit Etkin
IMPORTANCE: Psychiatric diagnoses are currently distinguished based on sets of specific symptoms. However, genetic and clinical analyses find similarities across a wide variety of diagnoses, suggesting that a common neurobiological substrate may exist across mental illness. OBJECTIVE: To conduct a meta-analysis of structural neuroimaging studies across multiple psychiatric diagnoses, followed by parallel analyses of 3 large-scale healthy participant data sets to help interpret structural findings in the meta-analysis...
April 2015: JAMA Psychiatry
https://www.readbyqxmd.com/read/25503422/role-of-anatomical-region-and-hypoxia-on-angiogenic-markers-in-adipose-derived-stromal-cells
#17
Jacob Rinkinen, Jeffrey Lisiecki, Eboda Oluwatobi, Jonathan Peterson, Sara De La Rosa, Kavitha Ranganathan, Stewart C Wang, Paul S Cederna, Benjamin Levi
BACKGROUND: Recent research into adipose-derived stem cells (ASCs) suggests that anatomical location has a major impact on the metabolic profile and differentiation capacity of ASCs. By having a better understanding of how various ASCs respond to cellular stressors such as hypoxia, which are induced during routine surgical procedures, we can facilitate future development of cell-based therapies to improve wound healing. PATIENTS AND METHODS: Human ASCs were isolated from the superficial and deep adipose layers of four patients undergoing elective abdominoplasty...
February 2015: Journal of Reconstructive Microsurgery
https://www.readbyqxmd.com/read/25439055/a-familial-risk-enriched-cohort-as-a-platform-for-testing-early-interventions-to-prevent-severe-mental-illness
#18
RANDOMIZED CONTROLLED TRIAL
Rudolf Uher, Jill Cumby, Lynn E MacKenzie, Jessica Morash-Conway, Jacqueline M Glover, Alice Aylott, Lukas Propper, Sabina Abidi, Alexa Bagnell, Barbara Pavlova, Tomas Hajek, David Lovas, Kathleen Pajer, William Gardner, Adrian Levy, Martin Alda
BACKGROUND: Severe mental illness (SMI), including schizophrenia, bipolar disorder and severe depression, is responsible for a substantial proportion of disability in the population. This article describes the aims and design of a research study that takes a novel approach to targeted prevention of SMI. It is based on the rationale that early developmental antecedents to SMI are likely to be more malleable than fully developed mood or psychotic disorders and that low-risk interventions targeting antecedents may reduce the risk of SMI...
2014: BMC Psychiatry
https://www.readbyqxmd.com/read/25219620/illness-severity-trait-anxiety-cognitive-impairment-and-heart-rate-variability-in-bipolar-disorder
#19
Boaz Levy
Numerous studies have documented a significant association between symptom severity and cognitive functioning in bipolar disorder (BD). These findings advanced speculations about a potential link between the physiological stress associated with illness severity and cognitive dysfunction. To explore this hypothesis, the current study employed heart rate variability (HRV) as a physiological measure that is sensitive to the effects of chronic stress, and a scale of trait anxiety for assessing a psychological condition that is correlated with hyper sympathetic arousal...
December 30, 2014: Psychiatry Research
https://www.readbyqxmd.com/read/24895037/ct-and-mr-imaging-of-multilocular-acinar-cell-cystadenoma-comparison-with-branch-duct-intraductal-papillary-mucinous-neoplasia-ipmns
#20
COMPARATIVE STUDY
Christophe Delavaud, Gaspard d'Assignies, Jérome Cros, Philippe Ruszniewski, Pascal Hammel, Philippe Levy, Anne Couvelard, Alain Sauvanet, Safi Dokmak, Valérie Vilgrain, Marie-Pierre Vullierme
OBJECTIVES: To describe CT and MR imaging findings of acinar cell cystadenoma (ACC) of the pancreas and to compare them with those of branch duct intraductal papillary mucinous neoplasia (BD-IPMN) to identify distinctive elements. METHODS: Five patients with ACC and the 20 consecutive patients with histologically proven BD-IPMN were retrospectively included. Clinical and biological information was collected and histological data reviewed. CT and MR findings were analysed blinded to pathological diagnosis in order to identify imaging diagnostic criteria of ACC...
September 2014: European Radiology
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