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https://www.readbyqxmd.com/read/28802833/new-pro-resolving-n-3-mediators-bridge-resolution-of-infectious-inflammation-to-tissue-regeneration
#1
REVIEW
Charles N Serhan, Nan Chiang, Jesmond Dalli
While protective, the acute inflammatory response when uncontrolled can lead to further tissue damage and chronic inflammation that is now widely recognized to play important roles in many commonly occurring diseases, such as cardiovascular disease, neurodegenerative diseases, metabolic syndrome, and many other diseases of significant public health concern. The ideal response to initial challenges of the host is complete resolution of the acute inflammatory response, which is now recognized to be a biosynthetically active process governed by specialized pro-resolving mediators (SPM)...
August 9, 2017: Molecular Aspects of Medicine
https://www.readbyqxmd.com/read/28765512/a-cluster-of-immunoresolvents-links-coagulation-to-innate-host-defense-in-human-blood
#2
Paul C Norris, Stephania Libreros, Nan Chiang, Charles N Serhan
Blood coagulation is a protective response that prevents excessive bleeding upon blood vessel injury. We investigated the relationship between coagulation and the resolution of inflammation and infection by lipid mediators (LMs) through metabololipidomics-based profiling of human whole blood (WB) during coagulation. We identified temporal clusters of endogenously produced prothrombotic and proinflammatory LMs (eicosanoids), as well as specialized proresolving mediators (SPMs). In addition to eicosanoids, a specific SPM cluster was identified that consisted of resolvin E1 (RvE1), RvD1, RvD5, lipoxin B4, and maresin 1, each of which was present at bioactive concentrations (0...
August 1, 2017: Science Signaling
https://www.readbyqxmd.com/read/28762976/formation-of-local-spin-state-concentration-waves-during-the-relaxation-from-a-photoinduced-state-in-a-spin-crossover-polymer
#3
Céline Mariette, Elzbieta Trzop, Serhane Zerdane, Pierre Fertey, Daopeng Zhang, Francisco J Valverde-Muñoz, José Antonio Real, Eric Collet
The complex relaxation from the photoinduced high-spin phase (PIHS) to the low-spin phase of the bimetallic two-dimensional coordination spin-crossover polymer [Fe[(Hg(SCN)3)2](4,4'-bipy)2]n is reported. During the thermal relaxation, commensurate and incommensurate spin-state concentration waves (SSCWs) form. However, contrary to the steps forming at thermal equilibrium, associated with long-range SSCW order, the SSCWs forming during the relaxation from the PIHS phase correspond to short-range order, revealed by diffuse X-ray scattering...
August 1, 2017: Acta Crystallographica Section B, Structural Science, Crystal Engineering and Materials
https://www.readbyqxmd.com/read/28755683/sulbutiamine-shows-promising-results-in-reducing-fatigue-in-patients-with-multiple-sclerosis
#4
Serhan Sevim, Hakan Kaleağası, Bahar Taşdelen
BACKGROUND: Fatigue is the most frequent and often debilitating symptom for patients with multiple sclerosis (MS). There are no available effective therapies for fatigue associated with MS, and it is unclear whether a successful therapy of MS leads to clinical improvement. Sulbutiamine is a lipophilic compound that crosses the blood-brain barrier more readily than thiamine and increases the levels of thiamine and thiamine phosphate esters in the brain. Whereas several clinical trials have demonstrated the beneficial effects of sulbutiamine in patients with asthenia, there have been no reports on the effects of sulbutiamine on fatigue in patients with MS...
August 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28752145/increased-levels-of-red-cell-distribution-width-is-correlated-with-presence-of-left-atrial-stasis-in-patients-with-non-valvular-atrial-fibrillation
#5
Adnan Kaya, Ceyhan Tukkan, Ahmet Taha Alper, Baris Gungor, Kazim Serhan Ozcan, Mustafa Adem Tatlisu, Ahmet Ilker Tekkesin, Fatma Ozpamuk Karadeniz, Gulay Gok, Osman Kayapinar
OBJECTIVE: Red cell distribution width (RDW) and neutrophil to lymphocyte ratio (NLR) have been found to be associated with non-valvular atrial fibrillation (AF) and cardiovascular diseases. However, correlation of these parameters with presence of left atrial (LA) thrombus and/or spontaneous echo contrast (SEC) in patients with non-valvular AF has not been clarified. This study was an investigation of correlation of RDW, NLR, and clinical risk factors with LA thrombus and dense SEC in patients with non-valvular AF in the Turkish population...
2017: Northern Clinics of Istanbul
https://www.readbyqxmd.com/read/28694398/renal-sympathetic-denervation-assisted-treatment-of-electrical-storm-due-to-polymorphic-ventricular-tachycardia-in-a-patient-with-cathecolaminergic-polymorphic-ventricular-tachycardia
#6
Tolga Aksu, Tümer Erdem Güler, Kazım Serhan Özcan, Serdar Bozyel, Kıvanç Yalın
Electrical storm (ES) is not a rare clinical entity. Sympathetic hyperactivity may play critical role in development and continuation of ES. Some recent reports have demonstrated that catheter-based renal sympathetic denervation (RSD) may reduce sympathetic activation and have a potential role in reducing arrhythmic burden. A 46-year-old man was admitted to clinic with frequent implantable cardioverter defibrillator shocks and ES related to catecholaminergic polymorphic ventricular tachycardia (VT). Tachycardia was unresponsive to administration of beta-blockers, verapamil, and flecainide...
July 2017: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/28694292/specialized-pro-resolving-mediators-spm-rescue-infant-mice-from-lethal-citrobacter-rodentium-infection-and-promote-immunity-against-re-infection
#7
Luis Alonso Diaz, Norman H Altman, Wasif Khan, Charles N Serhan, Becky Adkins
Infants are generally highly susceptible to oral pathogens. Intestinal infection and the associated diarrhea are significant global causes of morbidity and mortality in infants. Among the enteric pathogens, enteropathogenic E. coli (EPEC) stands out as showing the highest risk for infection-induced death in infants ≤ 12 months old. We have developed an experimental model of infant infection with EPEC, using the murine specific pathogen Citrobacter rodentium Our murine infant model is similar to EPEC infection in human infants since infant mice are much more susceptible to C...
July 10, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28690729/-unusual-location-of-multiple-hydatidosis-pancreatic-and-pelvic-about-a-case
#8
Lamyae Amro, Saloua El Fadili, Hind Serhane, Hafsa Sajiai, Salma Ait Batahar
Hydatid cyst is an infectious disease which is quite frequent in Morocco. Pelvic and pancreatic locations of this parasitic infection are rare, namely exceptional. We report the case of a 66-year old patient who was operated for liver hydatic cyst 6 years before, presenting for chest pain associated with hydatidoptysis. Chest X-ray objectified left hydropneumothorax. Thoraco-abdominopelvic CT showed mediastinal liquid mass as well as multiple hepatic, pancreatic (isthmus), pelvic and left under diaphragmatic cystic lesions...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28684089/quantitative-analysis-of-the-tumor-suppressor-dendrogenin-a-using-liquid-chromatography-tandem-mass-spectrometry
#9
Emmanuel Noguer, Régis Soules, Claude Netter, Citra Nagarathinam, Julie Leignadier, Emilie Huc-Claustre, Nizar Serhan, Arnaud Rives, Philippe de Medina, Sandrine Silvente-Poirot, Marc Poirot
Dendrogenin A (DDA) was recently identified as a mammalian cholesterol metabolite that displays tumor suppressor and neurostimulating properties at low doses. In breast tumors, DDA levels were found to be decreased compared to normal tissues, evidencing a metabolic deregulation of DDA production in cancers. DDA is an amino-oxysterol that contains three protonatable nitrogen atoms. This makes it physico-chemically different from other oxysterols and it therefore requires specific analytical methods We have previously used a two-step method for the quantification of DDA in biological samples: 1) DDA purification from a Bligh and Dyer extract by RP-HPLC using a 250×4...
July 3, 2017: Chemistry and Physics of Lipids
https://www.readbyqxmd.com/read/28669251/an-algorithmic-approach-for-the-management-of-hand-deformities-in-dystrophic-epidermolysis-bullosa
#10
Serhan Tuncer, Billur Sezgin, Basar Kaya, Suhan Ayhan, Osman Latifoglu
Treatment of hand deformities in epidermolysis bullosa patients represents a challenging field in hand surgery practice, thus a systematic approach by a team is mandatory for a successful result. A simple and practical algorithm for the surgical treatment of hand deformities in EB was employed by the authors where the deformities of each digit in EB patients was categorized according to pseudosyndactyly and interphalangeal joint contracture severity for guidance during the surgical treatment. The current study retrospectively reviewed the medical records and photographic data of 13 EB patients followed in our department, for whom a systematic approach to the management and treatment was used...
July 2, 2017: Journal of Plastic Surgery and Hand Surgery
https://www.readbyqxmd.com/read/28667126/functional-implications-of-the-relaxin-rln-system-in-the-dog-throughout-pregnancy-and-at-term
#11
Marta Nowak, Aykut Gram, Alois Boos, Selim Aslan, Serhan Serhat Ay, Firdevs Önyay, Mariusz Kowalewski
Relaxin (RLN) is a key hormone of pregnancy in mammals best known for its involvement in connective tissue remodeling. In the domestic dog, placental RLN is the only known endocrine marker of pregnancy. However, knowledge is sparse regarding the spatio-temporal expression of RLN and its receptors (RXFP1 and RXFP2) in the canine uterus and placenta. Here, their expression was investigated in the pre-implantation uterus and utero-placental compartments (UtPl) at selected time points during gestation: post-implantation, mid-gestation, and at normal and antigestagen-induced luteolysis/abortion...
June 30, 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/28661440/online-recognition-of-daily-activities-by-color-depth-sensing-and-knowledge-models
#12
Carlos Fernando Crispim-Junior, Alvaro Gómez Uría, Carola Strumia, Michal Koperski, Alexandra König, Farhood Negin, Serhan Cosar, Anh Tuan Nghiem, Duc Phu Chau, Guillaume Charpiat, Francois Bremond
Visual activity recognition plays a fundamental role in several research fields as a way to extract semantic meaning of images and videos. Prior work has mostly focused on classification tasks, where a label is given for a video clip. However, real life scenarios require a method to browse a continuous video flow, automatically identify relevant temporal segments and classify them accordingly to target activities. This paper proposes a knowledge-driven event recognition framework to address this problem. The novelty of the method lies in the combination of a constraint-based ontology language for event modeling with robust algorithms to detect, track and re-identify people using color-depth sensing (Kinect(®) sensor)...
June 29, 2017: Sensors
https://www.readbyqxmd.com/read/28659053/posterior-hip-approach-yields-better-functional-results-vis-%C3%A3-vis-anterolateral-approach-in-total-hip-arthroplasty-for-patients-with-severe-hip-dysplasia-a-prospective-randomized-controlled-clinical-study
#13
Faruk Mehmet Çatma, Alper Öztürk, Serhan Ünlü, Önder Ersan, Murat Altay
OBJECTIVES: We aimed to compare functional outcomes of two common hip approaches for patients with severe hip dysplasia in total hip replacement (THR) surgery. MATERIALS AND METHODS: Seventy hips of 68 patients randomized into two groups with regard to hip approach as posterior (group I) and anterolateral (group II). All patients underwent THR surgery with femoral shortening osteotomy. The groups were compared for operation time, preoperative and 6 months after abductor muscle strengths (AMSs), gait disorders, union time of the osteotomied site and dislocation rates...
May 2017: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/28602942/the-novel-lipid-mediator-pd1n-3-dpa-an-overview-of-the-structural-elucidation-synthesis-biosynthesis-and-bioactions
#14
REVIEW
Trond Vidar Hansen, Jesmond Dalli, Charles N Serhan
Resolvins, protectins and maresins are individual families of specialized pro-resolving mediators biosynthesized from the dietary n-3 polyunsaturated fatty acids eicosapentaenoic acid and docosahexaenoic acid. These enzymatically oxygenated polyunsaturated lipid mediators were first elucidated during the resolution phase of acute inflammation in animal models of self-limited inflammation. Specialized pro-resolving mediators display potent bioactions when administrated in vivo. Biosynthetic pathway studies have revealed that individual lipoxygenases and cyclooxygenase-2 converts eicosapentaenoic acid and docosahexaenoic acid into distinct families of the resolvins, protectins and maresins...
June 7, 2017: Prostaglandins & Other Lipid Mediators
https://www.readbyqxmd.com/read/28557340/trka-is-a-binding-partner-of-npm-alk-that-promotes-the-survival-of-alk-t-cell-lymphoma
#15
Wenyu Shi, Suraj Konnath George, Bhawana George, Choladda V Curry, Albina Murzabdillaeva, Serhan Alkan, Hesham M Amin
Nucleophosmin-anaplastic lymphoma kinase-expressing (NPM-ALK(+) ) T-cell lymphoma is an aggressive neoplasm that is more commonly seen in children and young adults. The pathogenesis of NPM-ALK(+) T-cell lymphoma is not completely understood. It is characterized by the expression of the chimeric tyrosine kinase NPM-ALK. Wild-type ALK is a receptor tyrosine kinase that is physiologically expressed in neural tissues during early stages of human development, which suggests that ALK may interact with neurotrophic factors...
May 30, 2017: Molecular Oncology
https://www.readbyqxmd.com/read/28551915/-characteristics-of-large-pericardial-effusion-in-a-well-defined-geographical-region
#16
Moanis Serhan, Ruhi Abdallah, Shaul Atar
BACKGROUND: Pericardial effusion can occur as a result of primary pericardial disease or secondary to systemic disease. Analysis of the features of pericardial effusion in correlation with clinical and demographic findings can help clinicians to determine the correct diagnosis and to choose the appropriate treatment and reduce patient mortality and morbidity. METHODS: Retrospective analysis of the characteristics of pericardial effusion and the prevalence of the different etiologies and their correlation with demographics, clinical characteristics and medical history in 86 patients admitted to Galilee Medical Center from 2001 to 2010 who underwent pericardiocentesis or pericardial window...
May 2017: Harefuah
https://www.readbyqxmd.com/read/28538505/thalassemia-major-and-priapism-a-case-report-of-an-adolescent
#17
Sibel Öz, Serhan Küpeli, Gülay Sezgin, İbrahim Bayram
Priapism is defined as a prolonged pathologic penile erection without sexual stimulation. In children, priapism secondary to sickle cell disease or hematological malignancy is a frequent condition. Appropriate treatment of priapism varies; the treatment is primarily etiological, conservative management. In the present report, we aimed to present a case of asplenic thalassemia major who developed priapism, improved with hydration and ibuprofen treatment. Clinicians should take into account that priapism can be encountered in patients with thalassemia major...
May 22, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/28518180/the-effects-of-laser-with-different-parameters-and-crosshatching-on-fibroblast-adhesion-and-proliferation-to-implant-surfaces
#18
Hakki Çelebi, Pembegül Uyar Arpacı, Ilhami Çelik, Serhan Akman
PURPOSE: To compare the adhesion and proliferation effect of HGF-1 cells on pure titanium disks when the surfaces are unprocessed (machined surfaces after slicing) or modified with a laser. MATERIALS AND METHODS: Twenty-eight titanium disks were divided into four groups. Three surface topographies were created using an erbium fiber laser: group 1 (unidirectional application [no crosshatch]), group 2 (crosshatching in two directions), and group 3 (crosshatching in three directions)...
May 18, 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/28473988/in-vitro-evaluation-of-manual-torque-values-applied-to-implant-abutment-complex-by-different-clinicians-and-abutment-screw-loosening
#19
Onur Dincer Kose, Burcin Karataslı, Sabit Demircan, Taha Emre Kose, Erhan Cene, Serhan Aydın Aya, Mehmet Ali Erdem, Abdulkadir Burak Cankaya
Preload is applied to screws manually or using a torque wrench in dental implant systems, and the preload applied must be appropriate for the purpose. The aim of this study was to assess screw loosening and bending/torsional moments applied by clinicians of various specialties following application of manual tightening torque to combinations of implants and abutments. Ten-millimeter implants of 3.7 and 4.1 mm diameters and standard or solid abutments were used. Each group contained five implant-abutment combinations...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28472018/does-spanning-a-lateral-lumbar-interbody-cage-across-the-vertebral-ring-apophysis-increase-loads-required-for-failure-and-mitigate-endplate-violation
#20
David C Briski, Vijay K Goel, Bradford S Waddell, Hassan Serhan, Manoj K Kodigudla, Vivek Palepu, Anand K Agarwal, Joseph M Zavatsky
STUDY DESIGN: Randomized Biomechanical Cadaveric Study - Level II. OBJECTIVE: We aimed to elucidate that placing lateral lumbar interbody cages that span the stronger ring apophysis will require increasing loads for failure, decreasing rates of subsidence, regardless of bone density or endplate integrity. SUMMARY OF BACKGROUND DATA: There are several reports regarding the rates and grades of cage subsidence when utilizing the lateral lumbar interbody fusion technique...
May 2, 2017: Spine
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