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https://www.readbyqxmd.com/read/28892824/resolvin-d1-increases-mucin-secretion-in-cultured-rat-conjunctival-goblet-cells-via-multiple-signaling-pathways
#1
Marit Lippestad, Robin R Hodges, Tor P Utheim, Charles N Serhan, Darlene A Dartt
Purpose: Goblet cells in the conjunctiva secrete mucin into the tear film protecting the ocular surface. The proresolution mediator resolvin D1 (RvD1) regulates mucin secretion to maintain homeostasis during physiological conditions and in addition, actively terminates inflammation. We determined the signaling mechanisms used by RvD1 in cultured rat conjunctival goblet cells to increase intracellular [Ca2+] ([Ca2+]i) and induce glycoconjugate secretion. Methods: Increase in [Ca2+]i were measured using fura 2/AM and glycoconjugate secretion determined using an enzyme-linked lectin assay with the lectin Ulex Europaeus Agglutinin 1...
September 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28874620/diagnostic-value-of-platelet-indices-in-acute-appendicitis-and-comparison-with-histopathology
#2
Mehmet Emin Gu Nes, Mehmet Mehdi Deniz, Serhan Yılmaz
BACKGROUND: Acute appendicitis is one of the most common surgical emergencies. An early and accurate diagnosis of acute appendicitis is vital. Evidence for a link between platelets indices and inflammation disease comes from recent studies. We aimed to evaluate preoperative diagnostic values of platelet indices (Mean platelet volume-MPV, Platelet Distribution Width-PDW, Plateletcrit-PCT) and leukocyte count (WBC) in comparison with post-operative histopathology results in patients who underwent appendectomy...
2017: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/28838191/expansion-of-surveillance-for-vaccine-preventable-diseases-building-on-the-global-polio-laboratory-network-and-the-global-measles-and-rubella-laboratory-network-platforms
#3
Mick N Mulders, Fatima Serhan, James L Goodson, Joseph Icenogle, Barbara W Johnson, Paul A Rota
Laboratory networks were established to provide accurate and timely laboratory confirmation of infections, an essential component of disease surveillance systems. The World Health Organization (WHO) coordinates global laboratory surveillance of vaccine-preventable diseases (VPDs), including polio, measles and rubella, yellow fever, Japanese encephalitis, rotavirus, and invasive bacterial diseases. In addition to providing high-quality laboratory surveillance data to help guide disease control, elimination, and eradication programs, these global networks provide capacity-building and an infrastructure for public health laboratories...
July 1, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28838152/etiology-of-severe-acute-watery-diarrhea-in-children-in-the-global-rotavirus-surveillance-network-using-quantitative-polymerase-chain-reaction
#4
MULTICENTER STUDY
Darwin J Operario, James A Platts-Mills, Sandrama Nadan, Nicola Page, Mapaseka Seheri, Jeffrey Mphahlele, Ira Praharaj, Gagandeep Kang, Irene T Araujo, Jose Paulo G Leite, Daniel Cowley, Sarah Thomas, Carl D Kirkwood, Francis Dennis, George Armah, Jason M Mwenda, Pushpa Ranjan Wijesinghe, Gloria Rey, Varja Grabovac, Chipo Berejena, Chibumbya J Simwaka, Jeannine Uwimana, Jeevan B Sherchand, Hlaing Myat Thu, Geethani Galagoda, Isidore J O Bonkoungou, Sheriffo Jagne, Enyonam Tsolenyanu, Amadou Diop, Christabel Enweronu-Laryea, Sam-Aliyah Borbor, Jie Liu, Timothy McMurry, Benjamin Lopman, Umesh Parashar, John Gentsch, A Duncan Steele, Adam Cohen, Fatima Serhan, Eric R Houpt
Background: The etiology of acute watery diarrhea remains poorly characterized, particularly after rotavirus vaccine introduction. Methods: We performed quantitative polymerase chain reaction for multiple enteropathogens on 878 acute watery diarrheal stools sampled from 14643 episodes captured by surveillance of children <5 years of age during 2013-2014 from 16 countries. We used previously developed models of the association between pathogen quantity and diarrhea to calculate pathogen-specific weighted attributable fractions (AFs)...
July 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28831194/origin-and-invasion-of-the-emerging-infectious-pathogen-sphaerothecum-destruens
#5
Salma Sana, Emilie A Hardouin, Rodolphe E Gozlan, Didem Ercan, Ali Serhan Tarkan, Tiantian Zhang, Demetra Andreou
Non-native species are often linked to the introduction of novel pathogens with detrimental effects on native biodiversity. Since Sphaerothecum destruens was first discovered as a fish pathogen in the United Kingdom, it has been identified as a potential threat to European fish biodiversity. Despite this parasite's emergence and associated disease risk, there is still a poor understanding of its origin in Europe. Here, we provide the first evidence to support the hypothesis that S. destruens was accidentally introduced to Europe from China along with its reservoir host Pseudorasbora parva via the aquaculture trade...
August 23, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28802833/new-pro-resolving-n-3-mediators-bridge-resolution-of-infectious-inflammation-to-tissue-regeneration
#6
REVIEW
Charles N Serhan, Nan Chiang, Jesmond Dalli
While protective, the acute inflammatory response when uncontrolled can lead to further tissue damage and chronic inflammation that is now widely recognized to play important roles in many commonly occurring diseases, such as cardiovascular disease, neurodegenerative diseases, metabolic syndrome, and many other diseases of significant public health concern. The ideal response to initial challenges of the host is complete resolution of the acute inflammatory response, which is now recognized to be a biosynthetically active process governed by specialized pro-resolving mediators (SPM)...
September 1, 2017: Molecular Aspects of Medicine
https://www.readbyqxmd.com/read/28765512/a-cluster-of-immunoresolvents-links-coagulation-to-innate-host-defense-in-human-blood
#7
Paul C Norris, Stephania Libreros, Nan Chiang, Charles N Serhan
Blood coagulation is a protective response that prevents excessive bleeding upon blood vessel injury. We investigated the relationship between coagulation and the resolution of inflammation and infection by lipid mediators (LMs) through metabololipidomics-based profiling of human whole blood (WB) during coagulation. We identified temporal clusters of endogenously produced prothrombotic and proinflammatory LMs (eicosanoids), as well as specialized proresolving mediators (SPMs). In addition to eicosanoids, a specific SPM cluster was identified that consisted of resolvin E1 (RvE1), RvD1, RvD5, lipoxin B4, and maresin 1, each of which was present at bioactive concentrations (0...
August 1, 2017: Science Signaling
https://www.readbyqxmd.com/read/28762976/formation-of-local-spin-state-concentration-waves-during-the-relaxation-from-a-photoinduced-state-in-a-spin-crossover-polymer
#8
Céline Mariette, Elzbieta Trzop, Serhane Zerdane, Pierre Fertey, Daopeng Zhang, Francisco J Valverde-Muñoz, José Antonio Real, Eric Collet
The complex relaxation from the photoinduced high-spin phase (PIHS) to the low-spin phase of the bimetallic two-dimensional coordination spin-crossover polymer [Fe[(Hg(SCN)3)2](4,4'-bipy)2]n is reported. During the thermal relaxation, commensurate and incommensurate spin-state concentration waves (SSCWs) form. However, contrary to the steps forming at thermal equilibrium, associated with long-range SSCW order, the SSCWs forming during the relaxation from the PIHS phase correspond to short-range order, revealed by diffuse X-ray scattering...
August 1, 2017: Acta Crystallographica Section B, Structural Science, Crystal Engineering and Materials
https://www.readbyqxmd.com/read/28755683/sulbutiamine-shows-promising-results-in-reducing-fatigue-in-patients-with-multiple-sclerosis
#9
Serhan Sevim, Hakan Kaleağası, Bahar Taşdelen
BACKGROUND: Fatigue is the most frequent and often debilitating symptom for patients with multiple sclerosis (MS). There are no available effective therapies for fatigue associated with MS, and it is unclear whether a successful therapy of MS leads to clinical improvement. Sulbutiamine is a lipophilic compound that crosses the blood-brain barrier more readily than thiamine and increases the levels of thiamine and thiamine phosphate esters in the brain. Whereas several clinical trials have demonstrated the beneficial effects of sulbutiamine in patients with asthenia, there have been no reports on the effects of sulbutiamine on fatigue in patients with MS...
August 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28752145/increased-levels-of-red-cell-distribution-width-is-correlated-with-presence-of-left-atrial-stasis-in-patients-with-non-valvular-atrial-fibrillation
#10
Adnan Kaya, Ceyhan Tukkan, Ahmet Taha Alper, Baris Gungor, Kazim Serhan Ozcan, Mustafa Adem Tatlisu, Ahmet Ilker Tekkesin, Fatma Ozpamuk Karadeniz, Gulay Gok, Osman Kayapinar
OBJECTIVE: Red cell distribution width (RDW) and neutrophil to lymphocyte ratio (NLR) have been found to be associated with non-valvular atrial fibrillation (AF) and cardiovascular diseases. However, correlation of these parameters with presence of left atrial (LA) thrombus and/or spontaneous echo contrast (SEC) in patients with non-valvular AF has not been clarified. This study was an investigation of correlation of RDW, NLR, and clinical risk factors with LA thrombus and dense SEC in patients with non-valvular AF in the Turkish population...
2017: Northern Clinics of Istanbul
https://www.readbyqxmd.com/read/28694398/renal-sympathetic-denervation-assisted-treatment-of-electrical-storm-due-to-polymorphic-ventricular-tachycardia-in-a-patient-with-cathecolaminergic-polymorphic-ventricular-tachycardia
#11
Tolga Aksu, Tümer Erdem Güler, Kazım Serhan Özcan, Serdar Bozyel, Kıvanç Yalın
Electrical storm (ES) is not a rare clinical entity. Sympathetic hyperactivity may play critical role in development and continuation of ES. Some recent reports have demonstrated that catheter-based renal sympathetic denervation (RSD) may reduce sympathetic activation and have a potential role in reducing arrhythmic burden. A 46-year-old man was admitted to clinic with frequent implantable cardioverter defibrillator shocks and ES related to catecholaminergic polymorphic ventricular tachycardia (VT). Tachycardia was unresponsive to administration of beta-blockers, verapamil, and flecainide...
July 2017: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/28694292/specialized-pro-resolving-mediators-spm-rescue-infant-mice-from-lethal-citrobacter-rodentium-infection-and-promote-immunity-against-re-infection
#12
Luis Alonso Diaz, Norman H Altman, Wasif Khan, Charles N Serhan, Becky Adkins
Infants are generally highly susceptible to oral pathogens. Intestinal infection and the associated diarrhea are significant global causes of morbidity and mortality in infants. Among the enteric pathogens, enteropathogenic E. coli (EPEC) stands out as showing the highest risk for infection-induced death in infants ≤ 12 months old. We have developed an experimental model of infant infection with EPEC, using the murine specific pathogen Citrobacter rodentium Our murine infant model is similar to EPEC infection in human infants since infant mice are much more susceptible to C...
July 10, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28690729/-unusual-location-of-multiple-hydatidosis-pancreatic-and-pelvic-about-a-case
#13
Lamyae Amro, Saloua El Fadili, Hind Serhane, Hafsa Sajiai, Salma Ait Batahar
Hydatid cyst is an infectious disease which is quite frequent in Morocco. Pelvic and pancreatic locations of this parasitic infection are rare, namely exceptional. We report the case of a 66-year old patient who was operated for liver hydatic cyst 6 years before, presenting for chest pain associated with hydatidoptysis. Chest X-ray objectified left hydropneumothorax. Thoraco-abdominopelvic CT showed mediastinal liquid mass as well as multiple hepatic, pancreatic (isthmus), pelvic and left under diaphragmatic cystic lesions...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28684089/quantitative-analysis-of-the-tumor-suppressor-dendrogenin-a-using-liquid-chromatography-tandem-mass-spectrometry
#14
Emmanuel Noguer, Régis Soules, Claude Netter, Citra Nagarathinam, Julie Leignadier, Emilie Huc-Claustre, Nizar Serhan, Arnaud Rives, Philippe de Medina, Sandrine Silvente-Poirot, Marc Poirot
Dendrogenin A (DDA) was recently identified as a mammalian cholesterol metabolite that displays tumor suppressor and neurostimulating properties at low doses. In breast tumors, DDA levels were found to be decreased compared to normal tissues, evidencing a metabolic deregulation of DDA production in cancers. DDA is an amino-oxysterol that contains three protonatable nitrogen atoms. This makes it physico-chemically different from other oxysterols and it therefore requires specific analytical methods We have previously used a two-step method for the quantification of DDA in biological samples: 1) DDA purification from a Bligh and Dyer extract by RP-HPLC using a 250×4...
July 3, 2017: Chemistry and Physics of Lipids
https://www.readbyqxmd.com/read/28669251/an-algorithmic-approach-for-the-management-of-hand-deformities-in-dystrophic-epidermolysis-bullosa
#15
Serhan Tuncer, Billur Sezgin, Basar Kaya, Suhan Ayhan, Osman Latifoglu
Treatment of hand deformities in epidermolysis bullosa patients represents a challenging field in hand surgery practice, thus a systematic approach by a team is mandatory for a successful result. A simple and practical algorithm for the surgical treatment of hand deformities in EB was employed by the authors where the deformities of each digit in EB patients was categorized according to pseudosyndactyly and interphalangeal joint contracture severity for guidance during the surgical treatment. The current study retrospectively reviewed the medical records and photographic data of 13 EB patients followed in our department, for whom a systematic approach to the management and treatment was used...
July 2, 2017: Journal of Plastic Surgery and Hand Surgery
https://www.readbyqxmd.com/read/28667126/functional-implications-of-the-relaxin-rln-system-in-the-dog-throughout-pregnancy-and-at-term
#16
Marta Nowak, Aykut Gram, Alois Boos, Selim Aslan, Serhan Serhat Ay, Firdevs Önyay, Mariusz Kowalewski
Relaxin (RLN) is a key hormone of pregnancy in mammals best known for its involvement in connective tissue remodeling. In the domestic dog, placental RLN is the only known endocrine marker of pregnancy. However, knowledge is sparse regarding the spatio-temporal expression of RLN and its receptors (RXFP1 and RXFP2) in the canine uterus and placenta. Here, their expression was investigated in the pre-implantation uterus and utero-placental compartments (UtPl) at selected time points during gestation: post-implantation, mid-gestation, and at normal and antigestagen-induced luteolysis/abortion...
June 30, 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/28661440/online-recognition-of-daily-activities-by-color-depth-sensing-and-knowledge-models
#17
Carlos Fernando Crispim-Junior, Alvaro Gómez Uría, Carola Strumia, Michal Koperski, Alexandra König, Farhood Negin, Serhan Cosar, Anh Tuan Nghiem, Duc Phu Chau, Guillaume Charpiat, Francois Bremond
Visual activity recognition plays a fundamental role in several research fields as a way to extract semantic meaning of images and videos. Prior work has mostly focused on classification tasks, where a label is given for a video clip. However, real life scenarios require a method to browse a continuous video flow, automatically identify relevant temporal segments and classify them accordingly to target activities. This paper proposes a knowledge-driven event recognition framework to address this problem. The novelty of the method lies in the combination of a constraint-based ontology language for event modeling with robust algorithms to detect, track and re-identify people using color-depth sensing (Kinect(®) sensor)...
June 29, 2017: Sensors
https://www.readbyqxmd.com/read/28659053/posterior-hip-approach-yields-better-functional-results-vis-%C3%A3-vis-anterolateral-approach-in-total-hip-arthroplasty-for-patients-with-severe-hip-dysplasia-a-prospective-randomized-controlled-clinical-study
#18
Faruk Mehmet Çatma, Alper Öztürk, Serhan Ünlü, Önder Ersan, Murat Altay
OBJECTIVES: We aimed to compare functional outcomes of two common hip approaches for patients with severe hip dysplasia in total hip replacement (THR) surgery. MATERIALS AND METHODS: Seventy hips of 68 patients randomized into two groups with regard to hip approach as posterior (group I) and anterolateral (group II). All patients underwent THR surgery with femoral shortening osteotomy. The groups were compared for operation time, preoperative and 6 months after abductor muscle strengths (AMSs), gait disorders, union time of the osteotomied site and dislocation rates...
May 2017: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/28602942/the-novel-lipid-mediator-pd1n-3-dpa-an-overview-of-the-structural-elucidation-synthesis-biosynthesis-and-bioactions
#19
REVIEW
Trond Vidar Hansen, Jesmond Dalli, Charles N Serhan
Resolvins, protectins and maresins are individual families of specialized pro-resolving mediators biosynthesized from the dietary n-3 polyunsaturated fatty acids eicosapentaenoic acid and docosahexaenoic acid. These enzymatically oxygenated polyunsaturated lipid mediators were first elucidated during the resolution phase of acute inflammation in animal models of self-limited inflammation. Specialized pro-resolving mediators display potent bioactions when administrated in vivo. Biosynthetic pathway studies have revealed that individual lipoxygenases and cyclooxygenase-2 converts eicosapentaenoic acid and docosahexaenoic acid into distinct families of the resolvins, protectins and maresins...
June 7, 2017: Prostaglandins & Other Lipid Mediators
https://www.readbyqxmd.com/read/28557340/trka-is-a-binding-partner-of-npm-alk-that-promotes-the-survival-of-alk-t-cell-lymphoma
#20
Wenyu Shi, Suraj Konnath George, Bhawana George, Choladda V Curry, Albina Murzabdillaeva, Serhan Alkan, Hesham M Amin
Nucleophosmin-anaplastic lymphoma kinase-expressing (NPM-ALK(+) ) T-cell lymphoma is an aggressive neoplasm that is more commonly seen in children and young adults. The pathogenesis of NPM-ALK(+) T-cell lymphoma is not completely understood. Wild-type ALK is a receptor tyrosine kinase that is physiologically expressed in neural tissues during early stages of human development, which suggests that ALK may interact with neurotrophic factors. The aberrant expression of NPM-ALK results from a translocation between the ALK gene on chromosome 2p23 and the NPM gene on chromosome 5q35...
September 2017: Molecular Oncology
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