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R S Dzhindzhikhadze, O N Dreval', V A Lazarev, A V Polyakov
AIM: Currently, there are many different surgical approaches to orbital pathology. This pathology rarely occurs in neurosurgical practice, and neurosurgeons have often used approaches that can be accompanied by negative cosmetic and functional outcomes. MATERIAL AND METHODS: We present a case report of orbital cavernoma removal via a minimally invasive approach. RESULTS: The presented case demonstrates successful removal of orbital cavernoma using the transpalpebral approach: a skin incision along a natural fold of the upper eyelid and orbitofrontal keyhole craniotomy...
2018: Zhurnal Voprosy Neĭrokhirurgii Imeni N. N. Burdenko
D Tasic, I Lazarevic, A Knezevic, L Tasic, A Pikula, Z Perisic, T Jovanovic, M Cupic
Persistent infection with one or more highly oncogenic human papillomaviruses (HPVs) or high-risk-HPV (HR-HPV) is necessary but not a sufficient aetiological agent for the development of cervical neoplasia. A number of viral, host, environmental and behavioural factors are suggested to be associated with the progression of cervical disorder. This study aimed to evaluate the impact of environmental and behavioural cofactors on the development of cervical disorders in HR-HPV-infected women in Serbia. A total of 541 women have been tested by PCR for the presence of HPV on the cervix...
June 20, 2018: Epidemiology and Infection
Ivan E Lazarev, Elena S Tomilovskaya, Inesa B Kozlovskaya
BACKGROUND: The purpose of this work was to investigate the brain's rhythmic activity during a simulated microgravity condition (namely dry immersion). METHODS: During dry immersion, which lasted for 5 d, nine subjects (healthy men, 20 to 29 yr of age) were individually placed in a tub (2.2 × 1.1 × 0.85 m) filled with water (temperature was kept constant at about 33°C). Subject floated in the tub without bodily support in the supine horizontal position, but isolated from the water by waterproof material...
July 1, 2018: Aerospace Medicine and Human Performance
Marija Mitkovic Voncina, Zeljka Kosutic, Danilo Pesic, Dejan Todorovic, Aleksandar Peulic, Milica Lazarevic, Ivana Rakovic Dobroslavic, Mina Djuric, Zagorka Bradic, Milica Pejovic Milovancevic, Dorothy Gotlib, Dusica Lecic Tosevski
There is an ongoing debate on the relationship between depression and anxiety, but data on similarities and differences in their predictor profiles are scarce. The aim of our study was to compare family and personality predictors of these disorders among 220 "emerging adults." As such, two clinical groups with noncomorbid depressive and anxiety disorders, and one healthy control group were assessed by sociodemographic questionnaires, Structured Clinical Interview for DSM-IV Disorders and NEO Personality Inventory, Revised...
June 15, 2018: Journal of Nervous and Mental Disease
Janis H Zickfeld, Thomas W Schubert, Beate Seibt, Johanna K Blomster, Patrícia Arriaga, Nekane Basabe, Agata Blaut, Amparo Caballero, Pilar Carrera, Ilker Dalgar, Yi Ding, Kitty Dumont, Valerie Gaulhofer, Asmir Gračanin, Réka Gyenis, Chuan-Peng Hu, Igor Kardum, Ljiljana B Lazarević, Leemamol Mathew, Sari Mentser, Ravit Nussinson, Mayuko Onuki, Darío Páez, Anna Pásztor, Kaiping Peng, Boban Petrović, José J Pizarro, Victoria Schönefeld, Magdalena Śmieja, Akihiko Tokaji, Ad Vingerhoets, Anja Vorster, Jonna Vuoskoski, Lei Zhu, Alan Page Fiske
English-speakers sometimes say that they feel "moved to tears," "emotionally touched," "stirred," or that something "warmed their heart;" other languages use similar passive contact metaphors to refer to an affective state. The authors propose and measure the concept of kama muta to understand experiences often given these and other labels. Do the same experiences evoke the same kama muta emotion across nations and languages? They conducted studies in 19 different countries, 5 continents, 15 languages, with a total of 3,542 participants...
June 11, 2018: Emotion
Julie Mareschal, Jacques Schrenzel, Vladimir Lazarevic, Laurence Genton
Currently, there is an increased interest in the role of gut microbiota in health issues. Evidence shows that an imbalance of gut microbiota or dysbiosis is involved in the mechanisms of weight changes. This review aims at summarizing the present knowledge between gut microbiota and malnutrition. Intestinal bacterial diversity and richness are altered in malnourished people compared to healthy people. The first studies on the modulation of the gut microbiota by probiotics, prebiotics, symbiotics, fecal transplantation and antibiotics for weight gain are encouraging...
June 6, 2018: Revue Médicale Suisse
M R Islamova, P V Lazarev, A F Safarova, Z D Kobalava
In this review article we discuss the clinical and prognostic value of echocardiographic evaluation methods of the right ventricular function and right ventricular - pulmonary artery coupling, advantages and disadvantages of echocardiography in comparison with other instrumental methods of investigation in patients with chronic heart failure.
May 2018: Kardiologiia
Peiqi Wang, Jun Hu, Shadi Ghadermarzi, Ali Raza, Douglas O'Connell, Amy Xiao, Faraz Ayyaz, Min Zhi, Yuanqi Zhang, Nimisha K Parekh, Mark Lazarev, Alyssa Parian, Steven R Brant, Marshall Bedine, Brindusa Truta, Pinjin Hu, Rupa Banerjee, Susan M Hutfless
BACKGROUND: Cigarette smoking is thought to increase the risk of Crohn's disease (CD) and exacerbate the disease course, with opposite roles in ulcerative colitis (UC). However, these findings are from Western populations, and the association between smoking and inflammatory bowel disease (IBD) has not been well studied in Asia. AIMS: We aimed to compare the prevalence of smoking at diagnosis between IBD cases and controls recruited in China, India, and the USA, and to investigate the impact of smoking on disease outcomes...
June 4, 2018: Digestive Diseases and Sciences
Luna Colagrossi, Lucas E Hermans, Romina Salpini, Domenico Di Carlo, Suzan D Pas, Marta Alvarez, Ziv Ben-Ari, Greet Boland, Bianca Bruzzone, Nicola Coppola, Carole Seguin-Devaux, Tomasz Dyda, Federico Garcia, Rolf Kaiser, Sukran Köse, Henrik Krarup, Ivana Lazarevic, Maja M Lunar, Sarah Maylin, Valeria Micheli, Orna Mor, Simona Paraschiv, Dimitros Paraskevis, Mario Poljak, Elisabeth Puchhammer-Stöckl, François Simon, Maja Stanojevic, Kathrine Stene-Johansen, Nijaz Tihic, Pascale Trimoulet, Jens Verheyen, Adriana Vince, Snjezana Zidovec Lepej, Nina Weis, Tülay Yalcinkaya, Charles A B Boucher, Annemarie M J Wensing, Carlo F Perno, Valentina Svicher
BACKGROUND: HBsAg immune-escape mutations can favor HBV-transmission also in vaccinated individuals, promote immunosuppression-driven HBV-reactivation, and increase fitness of drug-resistant strains. Stop-codons can enhance HBV oncogenic-properties. Furthermore, as a consequence of the overlapping structure of HBV genome, some immune-escape mutations or stop-codons in HBsAg can derive from drug-resistance mutations in RT. This study is aimed at gaining insight in prevalence and characteristics of immune-associated escape mutations, and stop-codons in HBsAg in chronically HBV-infected patients experiencing nucleos(t)ide analogues (NA) in Europe...
June 1, 2018: BMC Infectious Diseases
Katarina Tomovic, Jelena Lazarevic, Gordana Kocic, Marina Deljanin-Ilic, Marko Anderluh, Andrija Smelcerovic
Dipeptidyl peptidase-4 (DPP-4) cleaves N-terminal dipeptides, with Pro, Ala or Ser at the penultimate position, and, in that way, modulates biological activity of certain polypeptides. Due to its ubiquitous distribution, many pathological processes are associated with altered DPP-4 expression and activity. Besides the regulation of glucose metabolism, DPP-4 also exhibits many other systemic effects, and the inhibition of its activity might lead to cardiovascular and renal protection. Mechanisms underlying these protective effects of DPP-4 inhibition are ascribed to elevated bioavailability of its substrates, to impacts on mediators and signaling pathways that ameliorate cardiovascular and renal function through the suppression of oxidative stress, inflammation, fibrosis and apoptosis, improved endothelial function and tissue reparation...
May 28, 2018: Medicinal Research Reviews
R S Dzhindzhikhadze, O N Dreval', V A Lazarev, A V Polyakov, R L Kambiev
The concept of minimally invasive neurosurgery has significantly evolved in recent years, which is associated with improvements in diagnostics, microneurosurgical techniques, anesthesiology, and intraoperative imaging. MATERIAL AND METHODS: We present the preliminary results of using transpalpebral craniotomy in surgery of supratentorial aneurysms and anterior cranial fossa tumors. In the period between 2015 and 2107, we used this approach in surgical treatment of 30 aneurysms (10 aneurysms in the 'cold' period of hemorrhage and 20 unruptured aneurysms) and 10 anterior cranial fossa base tumors...
2018: Zhurnal Voprosy Neĭrokhirurgii Imeni N. N. Burdenko
Mirjana Dimitrijević, Nevena Arsenović-Ranin, Biljana Bufan, Mirjana Nacka-Aleksić, Mirjana Lazarević Macanović, Petar Milovanović, Marija Đurić, Jelena Sopta, Gordana Leposavić
Collagen-induced arthritis (CIA) is a frequently used animal model of rheumatoid arthritis, human autoimmune disease that exhibits clear sex bias in incidence and clinical course. Female Dark Agouti rats immunized for CIA showed also greater incidence and higher arthritic score than their male counterparts. The study investigated sex differences in mechanisms controlling the primary immune responses in draining lymph nodes (dLNs), as a factor contributing to this dimorphism. The higher frequencies of CD4 + CD25 + Foxp3- cells, presumably activated effector T (Teff) cells, and IL-17+, IFN-γ + and IL-17 + IFN-γ + T cells were found in female comapared with male rat dLNs...
May 21, 2018: Experimental and Molecular Pathology
Vladimir F Lazarev, Elizaveta A Dutysheva, Elena Y Komarova, Elena R Mikhaylova, Irina V Guzhova, Boris A Margulis
Massive neuronal death caused by a neurodegenerative pathology or damage due to ischaemia or traumatic brain injury leads to the appearance of cytosolic proteins in the extracellular space. We found that one of the most abundant cellular polypeptides, glyceraldehyde-3-phosphate dehydrogenase (GAPDH), appearing in the medium of dying cells or body fluids is able to form aggregates that are cytotoxic to adjacent cells. Since we previously showed that the hydrocortisone derivative RX624 can inhibit the ability of GAPDH to transport the enzyme complex with polyglutamine and reduce the cytotoxicity of the complex, we explored the effects of GAPDH on SH-SY5Y neuroblastoma cells...
May 16, 2018: Biochemical and Biophysical Research Communications
I Labunska, V Kashparov, S Levchuk, D Santillo, P Johnston, S Polishchuk, N Lazarev, Y Khomutinin
This study reports for the first time temporal trends for the period of 2011-2016 in 137 Cs content in cow's milk originating from private farms and households of 14 settlements located in the territories of the Rivne region, Ukraine. These areas are still radioactively contaminated as a result of the accident at the Chernobyl Nuclear Power Plant (ChNPP) in 1986. In 2016, the average 137 Cs activity concentration in milk exceeded the Ukrainian Permissible Level (PL) for adults of 100 Bq/l in samples from 6 settlements and the PL for children of 40 Bq/l in 8 settlements, reaching activity concentration of around 500 Bq/l in some samples...
May 15, 2018: Environment International
S Rappaport, A Vanderburg, T Jacobs, D LaCourse, J Jenkins, A Kraus, A Rizzuto, D W Latham, A Bieryla, M Lazarevic, A Schmitt
We present the first good evidence for exocomet transits of a host star in continuum light in data from the Kepler mission. The Kepler star in question, KIC 3542116, is of spectral type F2V and is quite bright at Kp = 10. The transits have a distinct asymmetric shape with a steeper ingress and slower egress that can be ascribed to objects with a trailing dust tail passing over the stellar disk. There are three deeper transits with depths of ≃ 0.1% that last for about a day, and three that are several times more shallow and of shorter duration...
February 21, 2018: Monthly Notices of the Royal Astronomical Society
Mlađan Golubović, Milan Lazarević, Dragan Zlatanović, Dane Krtinić, Viktor Stoičkov, Bojan Mladenović, Dragan J Milić, Dušan Sokolović, Aleksandar M Veselinović
Up to this date, there has been an ongoing debate about the mode of action of general anesthetics, which have postulated many biological sites as targets for their action. However, postoperative nausea and vomiting are common problems in which inhalational agents may have a role in their development. When a mode of action is unknown, QSAR modelling is essential in drug development. To investigate the aspects of their anesthetic, QSAR models based on the Monte Carlo method were developed for a set of polyhalogenated ethers...
April 13, 2018: Computational Biology and Chemistry
Diego Farinello, Monika Wozińska, Elisa Lenti, Luca Genovese, Silvia Bianchessi, Edoardo Migliori, Nicolò Sacchetti, Alessia di Lillo, Maria Teresa Sabrina Bertilaccio, Claudia de Lalla, Roberta Valsecchi, Sabrina Bascones Gleave, David Lligé, Cristina Scielzo, Laura Mauri, Maria Grazia Ciampa, Lydia Scarfò, Rosa Bernardi, Dejan Lazarevic, Blanca Gonzalez-Farre, Lucia Bongiovanni, Elias Campo, Andrea Cerutti, Maurilio Ponzoni, Linda Pattini, Federico Caligaris-Cappio, Paolo Ghia, Andrea Brendolan
In chronic lymphocytic leukemia (CLL), the non-hematopoietic stromal microenvironment plays a critical role in promoting tumor cell recruitment, activation, survival, and expansion. However, the nature of the stromal cells and molecular pathways involved remain largely unknown. Here, we demonstrate that leukemic B lymphocytes induce the activation of retinoid acid synthesis and signaling in the microenvironment. Inhibition of RA-signaling in stromal cells causes deregulation of genes associated with adhesion, tissue organization and chemokine secretion including the B-cell chemokine CXCL13...
May 3, 2018: Nature Communications
Irina V Ekimova, Daria V Plaksina, Yuri F Pastukhov, Ksenia V Lapshina, Vladimir F Lazarev, Elena R Mikhaylova, Sergey G Polonik, Bibhusita Pani, Boris A Margulis, Irina V Guzhova, Evgeny Nudler
Molecular chaperone HSP70 (HSPA1A) has therapeutic potential in conformational neurological diseases. Here we evaluate the neuroprotective function of the chaperone in a rat model of Parkinson's disease (PD). We show that the knock-down of HSP70 (HSPA1A) in dopaminergic neurons of the Substantia nigra causes an almost 2-fold increase in neuronal death and multiple motor disturbances in animals. Conversely, pharmacological activation of HSF1 transcription factor and enhanced expression of inducible HSP70 with the echinochrome derivative, U-133, reverses the process of neurodegeneration, as evidenced by а increase in the number of tyrosine hydroxylase-containing neurons, and prevents the motor disturbances that are typical of the clinical stage of the disease...
August 2018: Experimental Neurology
R Dzhindzhikhadze, A Kiselev, O Dreval, V Lazarev, A Polyakov
Minimally invasive neurosurgery has significantly evolved over the last several decades. This is due to the improvement of neurodiagnostics, microneurosurgical techniques, neuroanesthesiology and intraoperative imaging. Aim - authors present the results of the use of minimally invasive surgery (MIS) in cerebral aneurysms. In the period 2013-2017, we used 4 minimally invasive approaches in 240 patients with 246 aneurysms. The choice of surgical approach was determined after a thorough evaluation of the intracranial structures and aneurysms...
March 2018: Georgian Medical News
Weston Bettner, Anthony Rizzo, Steven Brant, Sharon Dudley-Brown, Jonathan Efron, Sandy Fang, Susan Gearhart, Michael Marohn, Alyssa Parian, Maryam Kherad Pezhouh, Joanna Melia, Bashar Safar, Brindusa Truta, Elizabeth Wick, Mark Lazarev
Background: In inflammatory bowel disease (IBD), many scenarios call for fecal diversion, leaving behind defunctionalized bowel. The theoretical risk of colorectal cancer (CRC) in this segment is frequently cited as a reason for resection. To date, no studies have characterized the incidence of neoplasia in the diverted colorectal segments of IBD patients. Methods: A retrospective cohort analysis was conducted for IBD patients identified through a tertiary care center pathology database...
April 23, 2018: Inflammatory Bowel Diseases
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