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Daniela V Šojić Merkulov, Vesna N Despotović, Nemanja D Banić, Sanja J Armaković, Nina L Finčur, Marina J Lazarević, Dragana D Četojević-Simin, Dejan Z Orčić, Marija B Radoičić, Zoran V Šaponjić, Mirjana I Čomor, Biljana F Abramović
A comprehensive study of the removal of selected biologically active compounds (pharmaceuticals and pesticides) from different water types was conducted using bare TiO2 nanoparticles and TiO2 /polyaniline (TP-50, TP-100, and TP-150) nanocomposite powders. In order to investigate how molecular structure of the substrate influences the rate of its removal, we compared degradation efficiency of the initial substrates and degree of mineralization for the active components of pharmaceuticals (propranolol, and amitriptyline) and pesticides (sulcotrione, and clomazone) in double distilled (DDW) and environmental waters...
April 18, 2018: Environmental Pollution
Andreja Leskovac, Sandra Petrovic, Tamara Lazarevic-Pasti, Milena Krstic, Vesna Vasic
In recent years, the search for effective anticancer compounds based on transition metal complexes has been the focus of medical investigations. The synergy between the ruthenium(II) and N-alkylphenothiazine counter-ions (chlorpromazine hydrochloride, thioridazine hydrochloride and trifluoperazine dihydrochloride, respectively) through the formation of three different complexes (1-3) was investigated. We explored whether the selected counter-ions and complexes might affect redox homeostasis and genome integrity of normal human blood cells, and induce an inhibition of Na+ /K+ -ATPase and AChE at pharmacologically relevant doses...
April 11, 2018: Journal of Biological Inorganic Chemistry: JBIC
Vladimir S Lazarev, Serhii A Nazarovets
No abstract text is available yet for this article.
April 2018: Nature
Vanja P Ničković, Tatjana Novaković, Slavica Lazarević, Ljiljana Šulović, Zorica Živković, Jovan Živković, Bojan Mladenović, Nikola M Stojanović, Vladmir Petrović, Dušan T Sokolović
AIMS: The present study was designed to compare the ameliorating potential of pre- and post-treatments with melatonin, a potent natural antioxidant, in the carbon tetrachloride-induced rat liver damage model by tracking changes in enzymatic and non-enzymatic liver tissue defense parameters, as well as in the occurring pathohistological changes. MAIN METHODS: Rats from two experimental groups were treated with melatonin before and after CCl4 administration, while the controls, negative and positive, received vehicle/melatonin and CCl4 , respectively...
April 4, 2018: Life Sciences
V Y Brodsky, L A Malchenko, D S Lazarev, N N Butorina, T K Dubovaya, N D Zvezdina
The kinetics of protein synthesis was investigated in primary cultures of hepatocytes from old rats in serum-free medium. The rats were fed mixed fodder supplemented with glutamic acid and then transferred to a regular mixed fodder. The amplitude of protein synthesis rhythm in hepatocytes isolated from these rats increased on average 2-fold in comparison with the rats not receiving glutamic acid supplement. Based on this indicator reflecting the degree of cell-cell interactions, the cells from old rats were not different from those of young rats...
March 2018: Biochemistry. Biokhimii︠a︡
Stanislav Lazarev, Vishal Gupta, Zahra Ghiassi-Nejad, Brett Miles, Bethann Scarborough, Krzysztof J Misiukiewicz, Batya Reckson, Ren-Dih Sheu, Richard L Bakst
Purpose: Factors related to premature discontinuation of curative radiation therapy (PDCRT) are understudied. This study aimed to examine causes and clinical outcomes of PDCRT at our institution by investigating the most common anatomical site associated with PDCRT. Methods and materials: Among the 161 patients with PDCRT of various anatomic sites at our institution between 2010 and 2017, 36% received radiation to the head and neck region. Pertinent demographic, clinical, and treatment-related data on these 58 patients were collected...
January 2018: Advances in Radiation Oncology
I P Baskova, S N Kalabushev, D N Akhaev, P A Bobrovsky, V A Manuvera, V N Lazarev
INTRODUCTION: Known thrombolytic agents either break peptide bonds in the fibrin molecule or act as plasminogen activators, which also results in peptide bond cleavage. In thrombi, fibrin molecules are known to be cross-linked by isopeptide bonds, the formation of which is mediated by factor XIIIa. In this work, we studied the dissolution of thrombi via isopeptide bond cleavage using a recombinant destabilase. Destabilase is an enzyme secreted from the medicinal leech salivary gland. This enzyme exhibits muramidase (lysozyme) activity, in addition to endo-ε-(γ-Glu)-Lys-isopeptidase activity, which is responsible for isopeptide bond cleavage...
March 12, 2018: Thrombosis Research
L E Gorelova
The article presents the history of organization of the Society of Moscow scientific institute. The materials are cited concerning its such first institutes of experimental biology, physiology and physics and also about the first directors of these institutes -- P.P. Lazarev, N.K. Koltsov, M.N. Shaternikov.
July 2017: Problemy Sot︠s︡ialʹnoĭ Gigieny, Zdravookhranenii︠a︡ i Istorii Medit︠s︡iny
Emanuel Della-Torre, Emanuele Bozzalla-Cassione, Clara Sciorati, Eliana Ruggiero, Marco Lanzillotta, Silvia Bonfiglio, Hamid Mattoo, Cory A Perugino, Enrica Bozzolo, Lucrezia Rovati, Paolo Giorgio Arcidiacono, Gianpaolo Balzano, Dejan Lazarevic, Chiara Bonini, Massimo Falconi, John H Stone, Lorenzo Dagna, Shiv Pillai, Angelo A Manfredi
OBJECTIVE: An unconventional population of CD4+ SLAMF7+ cytotoxic TEM cells (CD4+ CTLs) has been linked causally to IgG4-related disease (IgG4-RD). Glucocorticoids represent the first line therapeutic approach in patients with IgG4-RD but their mechanism of action in this specific condition remains unknown. Here we describe the impact of glucocorticoids on CD4+ CTLs in IgG4-RD. METHODS: CD8α, granzyme A, perforin, and SLAMF7 expression within the effector/memory compartment of CD45RO (TEM ) and CD45RA (TEMRA ) CD4+ T cells was quantified by flow cytometry in 18 active IgG4-RD patients at baseline and after 6 months of glucocorticoid treatment...
March 2, 2018: Arthritis & Rheumatology
Alyssa M Parian, Mark G Lazarev
The serrated neoplasia pathway is thought to account for up to 30% of sporadic colorectal cancer, but its role in inflammatory bowel disease (IBD)-related colorectal cancer is still not well elucidated. Hyperplastic polyps are not thought to impart an increased risk of colorectal cancer; however, sessile serrated adenomas/polyps and traditional serrated adenomas may have malignant potential. From the limited research currently available, this appears to hold true for IBD patients as well. IBD patients do not seem to be at a higher risk of typical serrated colorectal lesions than the general population, but it is still not known if they have a quicker progression to colorectal cancer...
January 2018: Gastroenterology & Hepatology
Julijana Trifković, Ljubomir Jovanović, Miloje Đurić, Snežana Stevanović-Đorđević, Svetlana Milanović, Miodrag Lazarević, Željko Sladojević, Danijela Kirovski
Season may affect calves' thermal comfort and behavior, but the data related to the overall influence of seasonal variations on dams' colostrum and postnatal adaptive capability of calves are limited. The aim of this study was to measure the effects of a 49-day-long low air temperature (LAT) season (5.20 ± 0.46 °C mean air temperature) and a 53-day-long high air temperature (HAT) season (27.40 ± 0.39 °C mean air temperature) on dams' colostrum quality and physiological, biochemical, hormonal, and oxidative stress parameters of their calves during the first 7 days of life...
February 26, 2018: International Journal of Biometeorology
Z D Kobalava, P V Lazarev, S V Villevalde
No abstract text is available yet for this article.
February 2018: Kardiologiia
Brittany L Adler, Maryam K Pezhouh, Amy Kim, Lan Luan, Qingfeng Zhu, Faiz Gani, Mark Yarchoan, Jonathan Chen, Lysandra Voltaggio, Alyssa Parian, Mark Lazarev, Gregory Y Lauwers, Timothy M Pawlik, Elizabeth A Montgomery, Elizabeth Jaffee, Dung T Le, Janis M Taube, Robert A Anders
BACKGROUND: Use of the immune checkpoint inhibitor ipilimumab is sometimes complicated by ipilimumab-associated colitis (Ipi-AC), an immune-mediated colitis that mimics inflammatory bowel disease. OBJECTIVE: We sought to characterize the histopathologic and immunophenotypic features of Ipi-AC, and to directly compare these features to ulcerative colitis (UC). METHODS: This is a retrospective cohort study of 22 patients with Ipi-AC, 12 patients with treatment-naïve UC, and 5 controls with diarrhea but normal endoscopic findings...
February 21, 2018: Journal of Internal Medicine
N Eljabo, N Nikolic, J Carkic, D Jelovac, M Lazarevic, N Tanic, J Milasin
Despite adequate surgical resection, oral squamous cell carcinoma (OSCC) shows a high rate of recurrence and metastasis, which could be explained by the presence of molecular alterations in seemingly normal tumour margins and the entire oral mucosa. The aims of this study were (1) to assess the presence of gene amplification (c-Myc and HER2) and promoter methylation (p14 and p16) in the tumours, tumour margins, and unaffected oral mucosa of 40 OSCC patients, and (2) to evaluate the possibility of using these alterations as prognostic markers...
February 12, 2018: International Journal of Oral and Maxillofacial Surgery
Francesca Giannese, Alessandra Luchetti, Giulia Barbiera, Valentina Lampis, Claudio Zanettini, Gun Peggy Knudsen, Simona Scaini, Dejan Lazarevic, Davide Cittaro, Francesca R D'Amato, Marco Battaglia
Respiratory and emotional responses to blood-acidifying inhalation of CO2 are markers of some human anxiety disorders, and can be enhanced by repeatedly cross-fostering (RCF) mouse pups from their biological mother to unrelated lactating females. Yet, these dynamics remain poorly understood. We show RCF-associated intergenerational transmission of CO2 sensitivity in normally-reared mice descending from RCF-exposed females, and describe the accompanying alterations in brain DNA methylation patterns. These epigenetic signatures were compared to DNA methylation profiles of monozygotic twins discordant for emotional reactivity to a CO2 challenge...
February 2, 2018: Scientific Reports
O Yu Gorobtsov, N Mukharamova, S Lazarev, M Chollet, D Zhu, Y Feng, R P Kurta, J-M Meijer, G Williams, M Sikorski, S Song, D Dzhigaev, S Serkez, A Singer, A V Petukhov, I A Vartanyants
X-ray free-electron lasers (XFELs) provide extremely bright and highly spatially coherent x-ray radiation with femtosecond pulse duration. Currently, they are widely used in biology and material science. Knowledge of the XFEL statistical properties during an experiment may be vitally important for the accurate interpretation of the results. Here, for the first time, we demonstrate Hanbury Brown and Twiss (HBT) interferometry performed in diffraction mode at an XFEL source. It allowed us to determine the XFEL statistical properties directly from the Bragg peaks originating from colloidal crystals...
February 2, 2018: Scientific Reports
Tatyana V Vakhrusheva, Daria V Grigorieva, Irina V Gorudko, Alexey Sokolov, Valeria A Kostevich, Vassili N Lazarev, Vadim B Vasilyev, Sergey N Cherenkevich, Oleg M Panasenko
Myeloperoxidase (MPO), found mainly in neutrophils, is released in inflammation. MPO produces reactive halogen species (RHS) which are bactericidal agents. However, RHS overproduction, i.e. halogenative stress, can also damage host biomolecules, and MPO itself may be targeted by RHS. Therefore, we examined the susceptibility of MPO to inactivation by its primary products (HOCl, HOBr, HOSCN) and secondary products such as taurine monochloramine (TauCl) and monobromamine (TauBr). MPO was dose-dependently inhibited up to complete inactivity by treatment with HOCl or HOBr...
February 2, 2018: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
Ekaterina N Grafskaia, Nadezhda F Polina, Vladislav V Babenko, Daria D Kharlampieva, Pavel A Bobrovsky, Valentin A Manuvera, Tatyana E Farafonova, Nikolay A Anikanov, Vassili N Lazarev
As essential conservative component of the innate immune systems of living organisms, antimicrobial peptides (AMPs) could complement pharmaceuticals that increasingly fail to combat various pathogens exhibiting increased resistance to microbial antibiotics. Among the properties of AMPs that suggest their potential as therapeutic agents, diverse peptides in the venoms of various predators demonstrate antimicrobial activity and kill a wide range of microorganisms. To identify potent AMPs, the study reported here involved a transcriptomic profiling of the tentacle secretion of the sea anemone Cnidopus japonicus...
January 3, 2018: Journal of Bioinformatics and Computational Biology
Dimitri Marques Abramov, Tania Saad, Saint-Clair Gomes-Junior, Daniel de Souza E Silva, Izabel Araújo, Maria Elizabeth Lopes Moreira, Vladimir V Lazarev
OBJECTIVE: To study the effect of prenatal Zika virus (ZV) infection on brainstem function reflected in brainstem auditory evoked potentials (BAEPs). METHODS: In a cross-sectional study in 19 children (12 girls) with microcephaly related to ZV infection, aged between 12 and 62 weeks, the brainstem function was examined through BAEPs. The latencies of wave peaks I, III, and V of the left and right ears (n = 37) were standardized according to normative data, and compared between them by 2-tailed t test...
February 13, 2018: Neurology
Vladimir F Lazarev, Dmitry V Sverchinsky, Elena R Mikhaylova, Pavel I Semenyuk, Elena Y Komarova, Sergey A Niskanen, Alina D Nikotina, Anton V Burakov, Viktor G Kartsev, Irina V Guzhova, Boris A Margulis
Hsp70 chaperone controls proteostasis and anti-stress responses in rapidly renewing cancer cells, making it an important target for therapeutic compounds. To date several Hsp70 inhibitors are presented with remarkable anticancer activity, however their clinical application is limited by the high toxicity towards normal cells. This study aimed to develop assays to search for the substances that reduce the chaperone activity of Hsp70 and diminish its protective function in cancer cells. On our mind the resulting compounds alone should be safe and function in combination with drugs widely employed in oncology...
January 18, 2018: Cell Death & Disease
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