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https://www.readbyqxmd.com/read/28685687/modulators-of-acetylcholinesterase-activity-from-alzheimer-s-disease-to-anti-cancer-drugs
#1
Tamara Lazarević-Pašti, Andreja Leskovac, Tatjana Momić, Sandra Petrović, Vesna Vasić
BACKGROUND: Acetylcholinesterase (AChE) is involved in the termination of impulse transmission by rapid hydrolysis of the neurotransmitter acetylcholine in numerous cholinergic pathways in the central and peripheral nervous systems. The enzyme inactivation leads to acetylcholine accumulation, hyperstimulation of nicotinic and muscarinic receptors, and disrupted neurotransmission. Hence, acetylcholinesterase inhibitors, interacting with the enzyme as their primary target, are applied as relevant drugs for different neurodegenerative diseases (such as Alzheimer's and Parkinson's) as well as toxins...
July 5, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28679062/clinical-metagenomics-for-the-diagnostic-of-hospital-acquired-infections-promises-and-hurdles
#2
Stéphane Emonet, Vladimir Lazarevic, Jérôme Pugin, Jacques Schrenzel, Etienne Ruppé
No abstract text is available yet for this article.
July 5, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28670574/corrigendum-interaction-of-bacteroides-fragilis-toxin-with-outer-membrane-vesicles-reveals-new-mechanism-of-its-secretion-and-delivery
#3
Natalya B Zakharzhevskaya, Vladimir B Tsvetkov, Anna A Vanyushkina, Anna M Varizhuk, Daria V Rakitina, Victor V Podgorsky, Innokentii E Vishnyakov, Daria D Kharlampieva, Valentin A Manuvera, Fedor V Lisitsyn, Elena A Gushina, Vassili N Lazarev, Vadim M Govorun
[This corrects the article on p. 2 in vol. 7, PMID: 28144586.].
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28667090/lentiviral-vectors-escape-innate-sensing-but-trigger-p53-in-human-hematopoietic-stem-and-progenitor-cells
#4
Francesco Piras, Michela Riba, Carolina Petrillo, Dejan Lazarevic, Ivan Cuccovillo, Sara Bartolaccini, Elia Stupka, Bernhard Gentner, Davide Cittaro, Luigi Naldini, Anna Kajaste-Rudnitski
Clinical application of lentiviral vector (LV)-based hematopoietic stem and progenitor cells (HSPC) gene therapy is rapidly becoming a reality. Nevertheless, LV-mediated signaling and its potential functional consequences on HSPC biology remain poorly understood. We unravel here a remarkably limited impact of LV on the HSPC transcriptional landscape. LV escaped innate immune sensing that instead led to robust IFN responses upon transduction with a gamma-retroviral vector. However, reverse-transcribed LV DNA did trigger p53 signaling, activated also by non-integrating Adeno-associated vector, ultimately leading to lower cell recovery ex vivo and engraftment in vivo These effects were more pronounced in the short-term repopulating cells while long-term HSC frequencies remained unaffected...
June 30, 2017: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/28636963/t-bet-runs-interference
#5
Vanja Lazarevic, Susanne Szabo, Laurie H Glimcher
In this issue of Immunity, Iwata et al. (2017) report that the transcription factor T-bet acts as a selective repressor of the type I interferon (IFN) transcriptional program in response to IFN-γ signaling.
June 20, 2017: Immunity
https://www.readbyqxmd.com/read/28631086/nearly-a-third-of-high-grade-dysplasia-and-colorectal-cancer-is-undetected-in-patients-with-inflammatory-bowel-disease
#6
Swathi Eluri, Alyssa M Parian, Berkeley N Limketkai, Christina Y Ha, Steven R Brant, Sharon Dudley-Brown, Jonathan E Efron, Sandy G Fang, Susan L Gearhart, Michael R Marohn, Stephen J Meltzer, Safar Bashar, Brindusa Truta, Elizabeth A Montgomery, Mark G Lazarev
BACKGROUND: It is unclear whether intensive surveillance protocols have resulted in a decreased incidence of colorectal cancer (CRC) in inflammatory bowel disease (IBD). AIMS: To determine the prevalence and characteristics of IBD associated high-grade dysplasia (HGD) or CRC that was undetected on prior colonoscopy. METHODS: This is a single-center, retrospective study from 1994 to 2013. All participants had a confirmed IBD diagnosis and underwent a colectomy with either HGD or CRC found in the colectomy specimen...
June 19, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28625656/semi-automatic-volumetric-measurement-of-response-to-chemotherapy-in-lung-cancer-patients-how-wrong-are-we-using-recist
#7
Vladislav Greenberg, Irina Lazarev, Yigal Frank, Julia Dudnik, Samuel Ariad, Ilan Shelef
OBJECTIVES: Lung cancer typically starts as a near-spherical lesion, but as it grows it may acquire an irregular radiologic formation. RECIST is based on the assumption that tumors are spherical, and consequently, proportional changes of tumor volume and parallel changes in tumor diameter, and vice versa. Hence, a 30% decrease in diameter (2r) implies a 65% decrease of volume, and a 20% increase in diameter implies a 73% increase of volume. MATERIALS AND METHODS: We compared volumetric measurement based on multi-detector CT technology with calculated volume (CV) according to RECIST in a cohort of 43 patients with advanced, non-squamous cell type, lung cancer treated with a combination of platinum and pemetrexed...
June 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/28621883/determination-of-the-serine-palmitoyl-transferase-inhibitor-myriocin-by-electrospray-and-q-trap-mass-spectrometry
#8
Giuseppe Matteo Campisi, Paola Signorelli, Jessica Rizzo, Claudio Ghilardi, Jacopo Antognetti, Anna Caretti, Jelena S Lazarevic, Enrica Strettoi, Elena Novelli, Riccardo Ghidoni, Federico Maria Rubino, Rita Paroni
Myriocin, is a potent inhibitor of serine-palmitoyl-transferase, the first and rate-determining enzyme in the sphingolipids biosynthetic pathway. This study developed, validated and applied a LC-MS/MS method to measure Myriocin in minute specimens of animal tissue. The chemical analog 14-OH-Myriocin is used as the internal standard. The two molecules are extracted from the tissue homogenate by solid-phase extraction, separated by gradient reverse-phase liquid chromatography and measured by negative ion electrospray mass spectrometry in the triple quadrupole...
June 16, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28595172/routine-pouchoscopy-prior-to-ileostomy-takedown-may-not-be-necessary-in-patients-with-chronic-ulcerative-colitis
#9
Jennifer X Cai, Jasmine Barrow, Alyssa Parian, Steven R Brant, Sharon Dudley-Brown, Jonathan Efron, Sandy Fang, Susan Gearhart, Michael Marohn, Bashar Safar, Brindusa Truta, Elizabeth Wick, Mark Lazarev
BACKGROUND: Creation of a J pouch is the gold standard surgical intervention in the treatment of chronic ulcerative colitis (UC). Pouchoscopy prior to ileostomy takedown is commonly performed. We describe the frequency, indication, and findings on pouchoscopy, and determine if pouchoscopy affects rates of complications after takedown. METHODS: All UC or indeterminate inflammatory bowel disease patients with a J pouch were retrospectively evaluated from January 1994 to December 2014...
June 9, 2017: Digestive Diseases
https://www.readbyqxmd.com/read/28559794/possible-function-of-molecular-chaperones-in-diseases-caused-by-propagating-amyloid-aggregates
#10
REVIEW
Vladimir F Lazarev, Elena R Mikhaylova, Irina V Guzhova, Boris A Margulis
The vast majority of neurodegenerative pathologies stem from the formation of toxic oligomers and aggregates composed of wrongly folded proteins. These protein complexes can be released from pathogenic cells and enthralled by other cells, causing the formation of new aggregates in a prion-like manner. By this mechanism, migrating complexes can transmit a disorder to distant regions of the brain and promote gradually transmitting degenerative processes. Molecular chaperones can counteract the toxicity of misfolded proteins...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28551391/preoperative-vs-postoperative-radiation-therapy-in-localized-soft-tissue-sarcoma-nationwide-patterns-of-care-and-trends-in-utilization
#11
Stanislav Lazarev, Heather McGee, Erin Moshier, Meng Ru, Elizabeth G Demicco, Vishal Gupta
PURPOSE: The timing of perioperative radiation therapy (RT) in the treatment of soft tissue sarcoma (STS) varies among institutions. This study examines patterns of care, trends in utilization, and survival with preoperative versus postoperative RT for primary STS. METHODS AND MATERIALS: Using the National Cancer Data Base, we identified patients with stage I-III STS who underwent definitive surgery with either preoperative or postoperative RT between 2004 and 2012...
April 18, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28551260/fatty-acid-and-phenolic-profiles-of-almond-grown-in-serbia
#12
Slavica D Čolić, Milica M Fotirić Akšić, Kristina B Lazarević, Gordan N Zec, Uroš M Gašić, Dragana Č Dabić Zagorac, Maja M Natić
Almond production is not typical for Serbia however the existence of natural populations and unexpectedly suitable agro-climatic conditions initiated this kind of study. Total oil content and concentrations of the fatty acids, total phenolic content and radical-scavenging activity were determined in the kernel oil of 20 local almond selections originating from North Serbia and cultivars 'Marcona', 'Texas' and 'Troito'. Sixteen fatty acids were identified and quantified, with the most abundant being oleic acid and linoleic acid...
November 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28527181/physicochemical-parameters-as-a-tool-for-the-assessment-of-origin-of-honey
#13
Kristina B Lazarević, Milica S Jovetić, Živoslav Lj Tešić
Honey is a complex mixture of various substances, and its composition depends on both botanical and geographical origin, as well as anthropogenic factors. The accurate identification of honey origin guarantees the satisfaction of consumers' needs and has an impact on the honey market value. Physicochemical parameters, some of which are used in routine analysis of honey quality, could be useful for the assessment of its origin. In this review, special attention is paid to those studies that assessed the sugar and mineral composition of honey, whether they were investigated in terms of botanical or geographical origin, or for the characterization of honey type...
May 19, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28524127/-an-acute-subdural-hematoma-caused-by-rupture-of-a-middle-cerebral-artery-aneurysm
#14
R S Dzhindzhikhadze, O N Dreval', V A Lazarev, R L Kambiev
Acute subdural hematoma caused by cerebral aneurysm rupture is rare. We describe a clinical case of an acute subdural hematoma developed due to rupture of an aneurysm at the M1 segment bifurcation of the middle cerebral artery (MCA). The acute subdural hematoma associated with intracranial hypertension and transtentorial herniation resulted in a comatose condition. The patient underwent decompressive craniectomy, hematoma removal, and clipping of the aneurysm. A significant improvement was observed in the postoperative period...
2017: Zhurnal Voprosy Neĭrokhirurgii Imeni N. N. Burdenko
https://www.readbyqxmd.com/read/28499958/unexpected-persistence-of-extended-spectrum-%C3%AE-lactamase-producing-enterobacteriaceae-in-the-faecal-microbiota-of-hospitalised-patients-treated-with-imipenem
#15
N Grall, V Lazarevic, N Gaïa, C Couffignal, C Laouénan, E Ilic-Habensus, I Wieder, P Plesiat, C Angebault, M E Bougnoux, L Armand-Lefevre, A Andremont, X Duval, J Schrenzel
Imipenem is active against extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-E) but favours the intestinal emergence of resistance. The effects of imipenem on intestinal microbiota have been studied using culture-based techniques. In this study, the effects were investigated in patients using culture and metagenomic techniques. Seventeen hospitalised adults receiving imipenem were included in a multicentre study (NCT01703299, http://www.clinicaltrials.gov). Most patients had a history of antibiotic use and/or hospitalisation...
May 10, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28473842/genetic-diversity-of-croatian-common-bean-landraces
#16
Klaudija Carović-Stanko, Zlatko Liber, Monika Vidak, Ana Barešić, Martina Grdiša, Boris Lazarević, Zlatko Šatović
In Croatia, the majority of the common bean production is based on local landraces, grown by small-scale farmers in low input production systems. Landraces are adapted to the specific growing conditions and agro-environments and show a great morphological diversity. These local landraces are in danger of genetic erosion caused by complex socio-economic changes in rural communities. The low profitability of farms and their small size, the advanced age of farmers and the replacement of traditional landraces with modern bean cultivars and/or other more profitable crops have been identified as the major factors affecting genetic erosion...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28450110/a-hydrocortisone-derivative-binds-to-gapdh-and-reduces-the-toxicity-of-extracellular-polyglutamine-containing-aggregates
#17
Vladimir F Lazarev, Elena R Mikhaylova, Elizaveta A Dutysheva, Roman V Suezov, Irina V Guzhova, Boris A Margulis
Huntington's disease (HD) has been recently shown to have a horizontally transmitted, prion-like pathology. Thus, the migration of polyglutamine-containing aggregates to acceptor cells is important for the progression of HD. These aggregates contain glyceraldehyde-3-phosphate dehydrogenase (GAPDH), which increases their intracellular transport and their toxicity. Here, we show that RX624, a derivative of hydrocortisone that binds to GAPDH, prevents the formation of aggregates of GAPDH-polyglutamine excreted into the culture medium by PC-12 rat cells expressing mutant huntingtin...
April 24, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28442170/platinum-palladium-gold-and-ruthenium-complexes-as-anticancer-agents-current-clinical-uses-cytotoxicity-studies-and-future-perspectives
#18
REVIEW
Tatjana Lazarević, Ana Rilak, Živadin D Bugarčić
Metallodrugs offer potential for unique mechanism of drug action based on the choice of the metal, its oxidation state, the types and number of coordinated ligands and the coordination geometry. This review illustrates notable recent progress in the field of medicinal bioinorganic chemistry as many new approaches to the design of innovative metal-based anticancer drugs are emerging. Current research addressing the problems associated with platinum drugs has focused on other metal-based therapeutics that have different modes of action and on prodrug and targeting strategies in an effort to diminish the side-effects of cisplatin chemotherapy...
April 18, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28437467/mutant-uromodulin-expression-leads-to-altered-homeostasis-of-the-endoplasmic-reticulum-and-activates-the-unfolded-protein-response
#19
Céline Schaeffer, Stefania Merella, Elena Pasqualetto, Dejan Lazarevic, Luca Rampoldi
Uromodulin is the most abundant urinary protein in physiological conditions. It is exclusively produced by renal epithelial cells lining the thick ascending limb of Henle's loop (TAL) and it plays key roles in kidney function and disease. Mutations in UMOD, the gene encoding uromodulin, cause autosomal dominant tubulointerstitial kidney disease uromodulin-related (ADTKD-UMOD), characterised by hyperuricemia, gout and progressive loss of renal function. While the primary effect of UMOD mutations, retention in the endoplasmic reticulum (ER), is well established, its downstream effects are still largely unknown...
2017: PloS One
https://www.readbyqxmd.com/read/28373768/colonic-ulcerations-may-predict-steroid-refractory-course-in-patients-with-ipilimumab-mediated-enterocolitis
#20
Animesh Jain, Evan J Lipson, William H Sharfman, Steven R Brant, Mark G Lazarev
AIM: To investigate management of patients who develop ipilimumab-mediated enterocolitis, including association of endoscopic findings with steroid-refractory symptoms and utility of infliximab as second-line therapy. METHODS: We retrospectively reviewed all patients at our center with metastatic melanoma who were treated with ipilimumab between March 2011 and May 2014. All patients received a standard regimen of intravenous ipilimumab 3 mg/kg every 3 wk for four doses or until therapy was stopped due to toxicity or disease progression...
March 21, 2017: World Journal of Gastroenterology: WJG
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