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https://www.readbyqxmd.com/read/27902597/whole-exome-sequencing-of-independent-lung-adenocarcinoma-lung-squamous-cell-carcinoma-and-malignant-peritoneal-mesothelioma-a-case-report
#1
Irene Vanni, Simona Coco, Silvia Bonfiglio, Davide Cittaro, Carlo Genova, Federica Biello, Marco Mora, Valeria Rossella, Maria Giovanna Dal Bello, Anna Truini, Barbara Banelli, Dejan Lazarevic, Angela Alama, Erika Rijavec, Giulia Barletta, Francesco Grossi
The presence of multiple primary tumors (MPT) in a single patient has been identified with an increasing frequency. A critical issue is to establish if the second tumor represents an independent primary cancer or a metastasis. Therefore, the assessment of MPT clonal origin might help understand the disease behavior and improve the management/prognosis of the patient.Herein, we report a 73-year-old male smoker who developed 2 primary lung cancers (adenocarcinoma and squamous cell carcinoma) and a malignant peritoneal mesothelioma (PM)...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27877228/lymphangiogenesis-in-classical-hodgkin-lymphoma-preliminary-study-with-clinicopathological-correlations
#2
Daniel Benharroch, Isebrand Prinsloo, Jacob Gopas, Irena Lazarev
A role for lymphangiogenesis in metastatic breast and prostate cancers has been suggested recently. The relevance of lymphangiogenesis in cancer as a rule, and more specifically in classical Hodgkin lymphoma, is poorly understood in comparison with that of angiogenesis. In a preliminary (pilot) study we have investigated the role of lymphatic vessels growth in 19 cases of classical Hodgkin lymphoma stained with the D2-40 (podoplanin) antibody. In each case, three lymphatic vessels hot spots were scrutinized twice...
2016: Journal of Cancer
https://www.readbyqxmd.com/read/27872615/microbial-communities-of-conducting-and-respiratory-zones-of-lung-transplanted-patients
#3
Marie Beaume, Vladimir Lazarevic, Thilo Köhler, Nadia Gaïa, Oriol Manuel, John-David Aubert, Loïc Baerlocher, Laurent Farinelli, Paola Gasche, Jacques Schrenzel, Christian van Delden
Background: Lung transplantation (LT) is a recognized treatment for end-stage pulmonary disease. Bacteria from the recipient nasopharynx seed the new lungs leading to infections and allograft damage. Understanding the characteristics and topological variations of the microbiota may be important to apprehend the pathophysiology of allograft dysfunction. Objectives: To examine the characteristics and relationship of bacterial compositions between conducting and respiratory zones of the allograft. Methods: We performed 16S rRNA gene sequencing on bronchial aspirates (BAs) and bronchoalveolar lavages (BALs) collected in pairs in 19 patients at several time-points post-LT...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27867689/family-history-and-disease-outcomes-in-patients-with-crohn-s-disease-a-comparison-between-china-and-the-united-states
#4
Pei-Qi Wang, Jun Hu, Elie S Al Kazzi, Eboselume Akhuemonkhan, Min Zhi, Xiang Gao, Raquel Holand de Paula Pessoa, Sami Ghazaleh, Tuhina Cornelius, Suhel Abbas Sabunwala, Shadi Ghadermarzi, Kartikeya Tripathi, Mark Lazarev, Pin-Jin Hu, Susan Hutfless
AIM: To investigate the differences in family history of inflammatory bowel disease (IBD) and clinical outcomes among individuals with Crohn's disease (CD) residing in China and the United States. METHODS: We performed a survey-based cross-sectional study of participants with CD recruited from China and the United States. We compared the prevalence of IBD family history and history of ileal involvement, CD-related surgeries and IBD medications in China and the United States, adjusting for potential confounders...
November 6, 2016: World Journal of Gastrointestinal Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27861795/sex-specific-mitonuclear-epistasis-and-the-evolution-of-mitochondrial-bioenergetics-ageing-and-life-history-in-seed-beetles
#5
Mirko Đorđević, Biljana Stojković, Uroš Savković, Elina Immonen, Nikola Tucić, Jelica Lazarević, Göran Arnqvist
The role of mitochondrial DNA for the evolution of life-history traits remains debated. We examined mitonuclear effects on the activity of the multisubunit complex of the electron transport chain (ETC) involved in oxidative phosphorylation (OXPHOS) across lines of the seed beetle Acanthoscelides obtectus selected for a short (E) or a long (L) life for more than >160 generations. We constructed and phenotyped mitonuclear introgression lines, which allowed us to assess the independent effects of the evolutionary history of the nuclear and the mitochondrial genome...
November 9, 2016: Evolution; International Journal of Organic Evolution
https://www.readbyqxmd.com/read/27847560/left-ventricular-false-tendons-and-electrocardiogram-repolarization-abnormalities-in-healthy-young-subjects
#6
Zlatan Lazarevic, Emanuela Ciminelli, Federico Quaranta, Fabio Sperandii, Emanuele Guerra, Fabio Pigozzi, Paolo Borrione
AIM: To describe echocardiographically left ventricular false tendon characteristics and the correlation with ventricular repolarization abnormalities in young athletes. METHODS: Three hundred and sixteen healthy young athletes from different sport disciplines were evaluated from 2009 to 2011 during routine screening for agonistic sports eligibility. All subjects, as part of standard pre-participation screening medical evaluation, underwent a basal and post step test 12-lead electrocardiogram (ECG)...
October 26, 2016: World Journal of Cardiology
https://www.readbyqxmd.com/read/27801678/histone-demethylase-jarid1c-inactivation-triggers-genomic-instability-in-sporadic-renal-cancer
#7
Beatrice Rondinelli, Dalia Rosano, Elena Antonini, Michela Frenquelli, Laura Montanini, DaChuan Huang, Simona Segalla, Kosuke Yoshihara, Samir B Amin, Dejan Lazarevic, Bin Tean The, Roel G W Verhaak, P Andrew Futreal, Luciano Di Croce, Lynda Chin, Davide Cittaro, Giovanni Tonon
No abstract text is available yet for this article.
November 1, 2016: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27801402/-supraorbital-keyhole-craniotomy-in-surgery-of-anterior-circle-of-willis-aneurysms
#8
R S Dzhindzhikhadze, O N Dreval', V A Lazarev, R L Kambiev
The progress in surgical treatment of intracranial aneurysms is based on the introduction of modern minimally invasive techniques. Among the variety of keyhole approaches, supraorbital craniotomy is most often used in surgical treatment of anterior circle of willis aneurysms. The authors present the preliminary results of application of supraorbital keyhole craniotomy for anterior circle of willis aneurysms in 27 patients. Most of the patients had unruptured aneurysms (18 patients). Nine patients had SAH, and 4 of them were operated on in the acute period...
2016: Zhurnal Voprosy Neĭrokhirurgii Imeni N. N. Burdenko
https://www.readbyqxmd.com/read/27797328/-conformational-polymorphysm-of-g-rich-fragments-of-dna-alu-repeats-i-potential-noncanonical-structures
#9
A V Sekridova, A M Varizhuk, O N Tatarinova, V V Severov, N A Barinov, I P Smirnov, V N Lazarev, D V Klinov, G E Pozmogova
In this paper, we report results of systematic studies of conformational polymorphism of G-rich DNA fragments from Alu repeats. Alu retrotransposones are primate-specific short interspersed elements. Using the Alu sequence from the prooncogen bcl2 intron and the consensus AluSx sequence as representative examples, we determined characteristic Alu sites that are capable of adopting G-quadruplex (GQ) conformations (i.e., potential quadruplex sites - PQSAlu), and demonstrated by bioinformatics methods that those sites are Alu-specific in the human genome...
July 2016: Biomedit︠s︡inskai︠a︡ Khimii︠a︡
https://www.readbyqxmd.com/read/27795559/prevalence-and-characteristics-of-survivors-from-acute-myeloid-leukemia-in-sweden
#10
G Juliusson, J Abrahamsson, V Lazarevic, P Antunovic, Å Derolf, H Garelius, S Lehmann, K Myhr-Eriksson, L Möllgård, B Uggla, A Wahlin, L Wennström, M Höglund
Leukemia accepted article preview online, 31 October 2016. doi:10.1038/leu.2016.312.
October 31, 2016: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/27791029/crystal-structure-of-the-dna-binding-domain-of-the-transcription-factor-t-bet-suggests-simultaneous-recognition-of-distant-genome-sites
#11
Ce Feng Liu, Gabriel S Brandt, Quyen Q Hoang, Natalia Naumova, Vanja Lazarevic, Eun Sook Hwang, Job Dekker, Laurie H Glimcher, Dagmar Ringe, Gregory A Petsko
The transcription factor T-bet (Tbox protein expressed in T cells) is one of the master regulators of both the innate and adaptive immune responses. It plays a central role in T-cell lineage commitment, where it controls the TH1 response, and in gene regulation in plasma B-cells and dendritic cells. T-bet is a member of the Tbox family of transcription factors; however, T-bet coordinately regulates the expression of many more genes than other Tbox proteins. A central unresolved question is how T-bet is able to simultaneously recognize distant Tbox binding sites, which may be located thousands of base pairs away...
October 25, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27783295/interaction-of-serum-antibodies-from-breast-cancer-patients-with-synthetic-peptides
#12
S V Podlesnykh, E A Kolosova, D N Shcherbakov, A A Shaidurov, D S Anisimov, M A Ryazanov, S A Johnston, Ya N Shoikhet, V D Petrova, A F Lazarev, A I Chapoval
The blood serum of tumor patients contains antibodies recognizing tumor-associated antigens and other molecular products of tumor growth. We studied the interaction of blood antibodies from breast cancer patients with synthetic peptides that were applied on the microchip surface. The serum from healthy volunteers and breast cancer patients was shown to contain antibodies that interact with various peptides. Statistically significant between-group differences were observed in the level of binding with 122 informative peptides (0...
October 26, 2016: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/27777142/targeting-integrin-%C3%AE-4%C3%AE-7-in-steroid-refractory-intestinal-graft-versus-host-disease
#13
Yngvar Fløisand, Knut E A Lundin, Vladimir Lazarevic, Jørn Dehli Kristiansen, Liv T N Osnes, Geir E Tjønnfjord, Henrik Mikael Reims, Tobias Gedde-Dahl
Steroid refractory acute graft-versus-host-disease of the gut is a serious complication associated with high mortality after allogeneic stem cell transplantation. Treatment options are limited and not predictably effective. We describe the treatment of steroid-refractory acute graft-versus-host-disease with vedolizumab, an antibody directed against integrin α4β7, in 6 patients. All patients responded, and 4 of 6 patients are alive with a median follow-up of 10 months.
October 21, 2016: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/27743328/nanoscale-zerovalent-iron-nzvi-supported-by-natural-and-acid-activated-sepiolites-the-effect-of-the-nzvi-support-ratio-on-the-composite-properties-and-cd-2-adsorption
#14
Amal Juma Habish, Slavica Lazarević, Ivona Janković-Častvan, Bojan Jokić, Janez Kovač, Jelena Rogan, Đorđe Janaćković, Rada Petrović
Natural (SEP) and partially acid-activated (AAS) sepiolites were used to prepare composites with nanoscale zerovalent iron (nZVI) at different (SEP or AAS)/nZVI ratios in order to achieve the best nZVI dispersibility and the highest adsorption capacity for Cd(2+). Despite the higher surface area and pore volume of AAS, better nZVI dispersibility was achieved by using SEP as the support. On the other hand, a lower oxidation degree was achieved during the synthesis using AAS. X-ray photoelectron spectroscopy (XPS) analysis of the composite with the best nZVI dispersibility, before and after Cd(2+) adsorption, confirmed that the surface of the nZVI was composed of oxidized iron species...
October 14, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27717396/viable-phenotype-of-ilneb-syndrome-without-nephrotic-impairment-in-siblings-heterozygous-for-unreported-integrin-alpha3-mutations
#15
Elisa Adele Colombo, Luigina Spaccini, Ludovica Volpi, Gloria Negri, Davide Cittaro, Dejan Lazarevic, Salvatore Zirpoli, Andrea Farolfi, Cristina Gervasini, Maria Vittoria Cubellis, Lidia Larizza
BACKGROUND: Integrin α3 (ITGA3) gene mutations are associated with Interstitial Lung disease, Nephrotic syndrome and Epidermolysis bullosa (ILNEB syndrome). To date only six patients are reported: all carried homozygous ITGA3 mutations and presented a dramatically severe phenotype leading to death before age 2 years, from multi-organ failure due to interstitial lung disease and congenital nephrotic syndrome. The involvement of skin and cutaneous adnexa was variable with sparse hair and nail dysplasia combined or not to skin lesions ranging from skin fragility to epidermolysis bullosa-like blistering...
October 7, 2016: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/27715117/insight-into-the-narrow-structure-in-%C3%AE-photoproduction-on-the-neutron-from-helicity-dependent-cross-sections
#16
L Witthauer, M Dieterle, S Abt, P Achenbach, F Afzal, Z Ahmed, J R M Annand, H J Arends, M Bashkanov, R Beck, M Biroth, N S Borisov, A Braghieri, W J Briscoe, F Cividini, S Costanza, C Collicott, A Denig, E J Downie, P Drexler, M I Ferretti-Bondy, S Gardner, S Garni, D I Glazier, D Glowa, W Gradl, M Günther, G M Gurevich, D Hamilton, D Hornidge, G M Huber, A Käser, V L Kashevarov, S Kay, I Keshelashvili, R Kondratiev, M Korolija, B Krusche, A B Lazarev, J M Linturi, V Lisin, K Livingston, S Lutterer, I J D MacGregor, J Mancell, D M Manley, P P Martel, V Metag, W Meyer, R Miskimen, E Mornacchi, A Mushkarenkov, A B Neganov, A Neiser, M Oberle, M Ostrick, P B Otte, D Paudyal, P Pedroni, A Polonski, S N Prakhov, A Rajabi, G Reicherz, G Ron, T Rostomyan, A Sarty, C Sfienti, M H Sikora, V Sokhoyan, K Spieker, O Steffen, I I Strakovski, Th Strub, I Supek, A Thiel, M Thiel, A Thomas, M Unverzagt, Yu A Usov, S Wagner, N K Walford, D P Watts, D Werthmüller, J Wettig, M Wolfes, L Zana
The double polarization observable E and the helicity dependent cross sections σ_{1/2} and σ_{3/2} were measured for η photoproduction from quasifree protons and neutrons. The circularly polarized tagged photon beam of the A2 experiment at the Mainz MAMI accelerator was used in combination with a longitudinally polarized deuterated butanol target. The almost 4π detector setup of the Crystal Ball and TAPS is ideally suited to detect the recoil nucleons and the decay photons from η→2γ and η→3π^{0}...
September 23, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27705954/raman-spectroscopy-of-k-x-co2-y-se2-single-crystals-near-the-ferromagnet-paramagnet-transition
#17
M Opačić, N Lazarević, M M Radonjić, M Šćepanović, Hyejin Ryu, Aifeng Wang, D Tanasković, C Petrovic, Z V Popović
Polarized Raman scattering spectra of the K x Co2-y Se2 single crystals reveal the presence of two phonon modes, assigned as of the A 1g and B 1g symmetry. The absence of additional modes excludes the possibility of vacancy ordering, unlike in K x Fe2-y Se2. The ferromagnetic (FM) phase transition at [Formula: see text] K leaves a clear fingerprint on the temperature dependence of the Raman mode energy and linewidth. For [Formula: see text] the temperature dependence looks conventional, driven by the thermal expansion and anharmonicity...
December 7, 2016: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/27693347/genome-wide-association-study-identifies-african-specific-susceptibility-loci-in-african-americans-with-inflammatory-bowel-disease
#18
Steven R Brant, David T Okou, Claire L Simpson, David J Cutler, Talin Haritunians, Jonathan P Bradfield, Pankaj Chopra, Jarod Prince, Ferdouse Begum, Archana Kumar, Chengrui Huang, Suresh Venkateswaran, Lisa W Datta, Zhi Wei, Kelly Thomas, Lisa J Herrinton, Jan-Micheal A Klapproth, Antonio J Quiros, Jenifer Seminerio, Zhenqiu Liu, Jonathan S Alexander, Robert N Baldassano, Sharon Dudley-Brown, Raymond K Cross, Themistocles Dassopoulos, Lee A Denson, Tanvi A Dhere, Gerald W Dryden, John S Hanson, Jason K Hou, Sunny Z Hussain, Jeffrey S Hyams, Kim L Isaacs, Howard Kader, Michael D Kappelman, Jeffry Katz, Richard Kellermayer, Barbara S Kirschner, John F Kuemmerle, John H Kwon, Mark Lazarev, Ellen Li, David Mack, Peter Mannon, Dedrick E Moulton, Rodney D Newberry, Bankole O Osuntokun, Ashish S Patel, Shehzad A Saeed, Stephan R Targan, John F Valentine, Ming-Hsi Wang, Martin Zonca, John D Rioux, Richard H Duerr, Mark S Silverberg, Judy H Cho, Hakon Hakonarson, Michael E Zwick, Dermot P B McGovern, Subra Kugathasan
BACKGROUND & AIMS: The inflammatory bowel diseases (IBD) ulcerative colitis (UC) and Crohn's disease (CD) cause significant morbidity and are increasing in prevalence among all populations, including African Americans. More than 200 susceptibility loci have been identified in populations of predominantly European ancestry, but few loci have been associated with IBD in other ethnicities. METHODS: We performed 2 high-density, genome-wide scans comprising 2345 cases of African Americans with IBD (1646 with CD, 583 with UC, and 116 inflammatory bowel disease unclassified) and 5002 individuals without IBD (controls, identified from the Health Retirement Study and Kaiser Permanente database)...
September 28, 2016: Gastroenterology
https://www.readbyqxmd.com/read/27674406/adjuvant-radiation-in-the-tors-era-is-there-a-benefit-to-omitting-the-primary-site
#19
S Lazarev, B Todorov, J Tam, N Lee, V Gupta, R L Bakst
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27649141/extraordinary-adaptive-plasticity-of-colorado-potato-beetle-ten-striped-spearman-in-the-era-of-biotechnological-warfare
#20
Aleksandar Cingel, Jelena Savić, Jelica Lazarević, Tatjana Ćosić, Martin Raspor, Ann Smigocki, Slavica Ninković
Expanding from remote areas of Mexico to a worldwide scale, the ten-striped insect, the Colorado potato beetle (CPB, Leptinotarsa decemlineata Say), has risen from being an innocuous beetle to a prominent global pest. A diverse life cycle, phenotypic plasticity, adaptation to adverse conditions, and capability to detoxify or tolerate toxins make this insect appear to be virtually "indestructible". With increasing advances in molecular biology, tools of biotechnological warfare were deployed to combat CPB. In the last three decades, genetically modified potato has created a new challenge for the beetle...
2016: International Journal of Molecular Sciences
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