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https://www.readbyqxmd.com/read/28198584/the-farming-environment-protects-mice-from-allergen-induced-skin-contact-hypersensitivity
#1
Christophe P Frossard, Vladimir Lazarevic, Nadia Gaïa, Stefano Leo, Camille Doras, Walid Habre, Jacques Schrenzel, Danielle Burger, Philippe A Eigenmann
BACKGROUND: Being born and raised in a farm provides a long-lasting protection for allergies. The microbial environment provided by farm animals is crucial to induce this protective effect, although underlying immune mechanisms remain elusive. OBJECTIVE: To establish a mouse model of global exposure to the farming environment and to study immunologic changes linked to protection of allergy. METHODS: Mice colonies were bred in parallel in a farm cowshed and the University animal facility (AF)...
February 15, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28172933/p275-development-and-reliability-of-the-new-endoscopic-virtual-chromoendoscopy-score-the-picasso-score-the-paddington-international-virtual-chromoendoscopy-score-in-ulcerative-colitis
#2
M Iacucci, M Daperno, M Lazarev, R Arsenescu, G E Tontini, B C Lethebe, M W Lowerison, X Gui, V Villanacci, O Akinola, M Goetz, M Vecchi, H Neuman, S Ghosh, R Bisschops, R Kiesslich
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28172930/p488-does-statin-use-reduce-the-risk-of-j-pouch-related-complications-in-patients-with-inflammatory-bowel-disease
#3
P Kaimakliotis, M Lazarev, T Bayless, A Parian, S Brant, J Melia, B Truta
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28158167/the-rare-painful-phenomena-chronic-paroxysmal-hemicrania-tic-syndrome-as-a-clinically-isolated-syndrome-of-the-central-nervous-system
#4
Srdjan Ljubisavljevic, Ana Prazic, Miodrag Lazarevic, Dragan Stojanov, Dejan Savic, Slobadan Vojinovic
The association of paroxysmal hemicrania with trigeminal neuralgia (TN) has been described and called paroxysmal hemicrania-tic syndrome (PH-tic). We report the case of a patient diagnosed as having chronic PH-tic (CPH-tic) syndrome as a clinically isolated syndrome of the central nervous system (CNS) (CIS).A forty year old woman was admitted to our hospital suffering from right facial pain for the last 2 years. The attacks were paroxysmal, neuralgiform, consisting of throb-like sensations, which developed spontaneously or were triggered by different stimuli in right facial (maxilar and mandibular) areas...
February 2017: Pain Physician
https://www.readbyqxmd.com/read/28152233/incidence-and-prognostic-significance-of-isolated-trisomies-in-adult-acute-myeloid-leukemia-a-population-based-study-from-the-swedish-aml-registry
#5
Vladimir Lazarevic, Aldana Rosso, Gunnar Juliusson, Petar Antunovic, Åsa Rangert Derolf, Stefan Deneberg, Lars Möllgård, Bertil Uggla, Lovisa Wennström, Anders Wahlin, Martin Höglund, Sören Lehmann, Bertil Johansson
To ascertain the incidence/clinical implications of isolated autosomal trisomies in adult acute myeloid leukemia (AML), all such cases were retrieved from the Swedish AML Registry RESULTS: Of the 3,179 cytogenetically informative AMLs diagnosed January 1997 - May 2015, 246 (7.7%) had isolated trisomies. The frequency increased by age (2.4% at age 18-60 years vs. 23% at >60 years; P < 0.0001); the median age was 69 years. The five most common were +8 (4.0%), +13 (0.9%), +11 (0.8%), +21 (0.7%), and +4 (0...
February 2, 2017: European Journal of Haematology
https://www.readbyqxmd.com/read/28144586/interaction-of-bacteroides-fragilis-toxin-with-outer-membrane-vesicles-reveals-new-mechanism-of-its-secretion-and-delivery
#6
Natalya B Zakharzhevskaya, Vladimir B Tsvetkov, Anna A Vanyushkina, Anna M Varizhuk, Daria V Rakitina, Victor V Podgorsky, Innokentii E Vishnyakov, Daria D Kharlampieva, Valentin A Manuvera, Fedor V Lisitsyn, Elena A Gushina, Vassili N Lazarev, Vadim M Govorun
The only recognized virulence factor of enterotoxigenic Bacteroides fragilis (ETBF) that accompanies bloodstream infections is the zinc-dependent non-lethal metalloprotease B. fragilis toxin (BFT). The isolated toxin stimulates intestinal secretion, resulting in epithelial damage and necrosis. Numerous publications have focused on the interrelation of BFT with intestinal inflammation and colorectal neoplasia, but nothing is known about the mechanism of its secretion and delivery to host cells. However, recent studies of gram-negative bacteria have shown that outer membrane vesicles (OMVs) could be an essential mechanism for the spread of a large number of virulence factors...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28120183/erratum-to-vascular-access-registry-of-serbia-a-4-year-experience
#7
Tamara Jemcov, Nada Dimkovic, Dragan Jovanovic, Tanja Lazarevic, Igor Mitic, Radomir Naumovic, Sanja Simic-Ogrizovic, Radmila Velickovic
No abstract text is available yet for this article.
January 25, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28064125/effects-of-cultural-brokering-on-individual-wellbeing-and-family-dynamics-among-immigrant-youth
#8
Vanja Lazarevic
Over 90% of immigrant youth help their parents navigate the mainstream US culture, a process known as cultural brokering. Past research has indicated that brokering can often have negative effects on development of immigrant youth and their families. The current study builds on the past literature by examining how various aspects of brokering may impact individual wellbeing and family dynamics among first generation immigrant and refugee youth from Eastern Europe (N = 197, Mage = 22.93 (SD = 2.89), 63...
February 2017: Journal of Adolescence
https://www.readbyqxmd.com/read/28057814/increased-serum-interleukin-10-but-not-interleukin-4-level-in-children-with-mycoplasma-pneumoniae-pneumonia
#9
Biljana Medjo, Marina Atanaskovic-Markovic, Dimitrije Nikolic, Snezana Radic, Ivana Lazarevic, Ivana Cirkovic, Slobodanka Djukic
BACKGROUND: Mycoplasma pneumoniae (MP) is a common cause of community-acquired pneumonia in children, and it has been associated with wheezing. The aim of this study was to examine the serum level of interleukin (IL)-4 and IL-10 in children with Mycoplasma pneumoniae pneumonia (MPP) and to analyse them in relation to the presence of wheezing. METHODS: The study included 166 children with radiologically confirmed pneumonia. MP infection was confirmed by enzyme-linked immunosorbent assay (ELISA) serum MP-IgM and MP-IgG test and throat swab MP DNA with real-time polymerase chain reaction...
January 5, 2017: Journal of Tropical Pediatrics
https://www.readbyqxmd.com/read/27993998/the-pathogenic-role-of-nlrp3-inflammasome-activation-in-inflammatory-bowel-diseases-of-both-mice-and-humans
#10
Ling Liu, Ying Dong, Mei Ye, Shi Jin, Jianbo Yang, Maria E Joosse, Yu Sun, Jennifer Zhang, Mark Lazarev, Steven R Brant, Bashar Safar, Michael Marohn, Esteban Mezey, Xuhang Li
BACKGROUND AND AIMS: NLRP3 inflammasome is known to be involved in inflammatory bowel diseases. However, it is controversial if it is pathogenic or beneficial. This study evaluated the roles of NLRP3-inflammasome in the pathogenesis of inflammatory bowel disease in IL-10-/- mice and humans. METHODS: NLRP3 inflammasome in colonic mucosa, macrophages, and colonic epithelial cells were analyzed by Western blotting. The NLRP3 inflammasome components were studied by sucrose density gradient fractionation, chemical crosslinking and co-immunoprecipitation...
December 17, 2016: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/27939223/dominant-pole-placement-with-fractional-order-pid-controllers-d-decomposition-approach
#11
Petar D Mandić, Tomislav B Šekara, Mihailo P Lazarević, Marko Bošković
Dominant pole placement is a useful technique designed to deal with the problem of controlling a high order or time-delay systems with low order controller such as the PID controller. This paper tries to solve this problem by using D-decomposition method. Straightforward analytic procedure makes this method extremely powerful and easy to apply. This technique is applicable to a wide range of transfer functions: with or without time-delay, rational and non-rational ones, and those describing distributed parameter systems...
December 6, 2016: ISA Transactions
https://www.readbyqxmd.com/read/27902597/whole-exome-sequencing-of-independent-lung-adenocarcinoma-lung-squamous-cell-carcinoma-and-malignant-peritoneal-mesothelioma-a-case-report
#12
Irene Vanni, Simona Coco, Silvia Bonfiglio, Davide Cittaro, Carlo Genova, Federica Biello, Marco Mora, Valeria Rossella, Maria Giovanna Dal Bello, Anna Truini, Barbara Banelli, Dejan Lazarevic, Angela Alama, Erika Rijavec, Giulia Barletta, Francesco Grossi
The presence of multiple primary tumors (MPT) in a single patient has been identified with an increasing frequency. A critical issue is to establish if the second tumor represents an independent primary cancer or a metastasis. Therefore, the assessment of MPT clonal origin might help understand the disease behavior and improve the management/prognosis of the patient.Herein, we report a 73-year-old male smoker who developed 2 primary lung cancers (adenocarcinoma and squamous cell carcinoma) and a malignant peritoneal mesothelioma (PM)...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27877228/lymphangiogenesis-in-classical-hodgkin-lymphoma-preliminary-study-with-clinicopathological-correlations
#13
Daniel Benharroch, Isebrand Prinsloo, Jacob Gopas, Irena Lazarev
A role for lymphangiogenesis in metastatic breast and prostate cancers has been suggested recently. The relevance of lymphangiogenesis in cancer as a rule, and more specifically in classical Hodgkin lymphoma, is poorly understood in comparison with that of angiogenesis. In a preliminary (pilot) study we have investigated the role of lymphatic vessels growth in 19 cases of classical Hodgkin lymphoma stained with the D2-40 (podoplanin) antibody. In each case, three lymphatic vessels hot spots were scrutinized twice...
2016: Journal of Cancer
https://www.readbyqxmd.com/read/27872615/microbial-communities-of-conducting-and-respiratory-zones-of-lung-transplanted-patients
#14
Marie Beaume, Vladimir Lazarevic, Thilo Köhler, Nadia Gaïa, Oriol Manuel, John-David Aubert, Loïc Baerlocher, Laurent Farinelli, Paola Gasche, Jacques Schrenzel, Christian van Delden
Background: Lung transplantation (LT) is a recognized treatment for end-stage pulmonary disease. Bacteria from the recipient nasopharynx seed the new lungs leading to infections and allograft damage. Understanding the characteristics and topological variations of the microbiota may be important to apprehend the pathophysiology of allograft dysfunction. Objectives: To examine the characteristics and relationship of bacterial compositions between conducting and respiratory zones of the allograft. Methods: We performed 16S rRNA gene sequencing on bronchial aspirates (BAs) and bronchoalveolar lavages (BALs) collected in pairs in 19 patients at several time-points post-LT...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27867689/family-history-and-disease-outcomes-in-patients-with-crohn-s-disease-a-comparison-between-china-and-the-united-states
#15
Pei-Qi Wang, Jun Hu, Elie S Al Kazzi, Eboselume Akhuemonkhan, Min Zhi, Xiang Gao, Raquel Holand de Paula Pessoa, Sami Ghazaleh, Tuhina Cornelius, Suhel Abbas Sabunwala, Shadi Ghadermarzi, Kartikeya Tripathi, Mark Lazarev, Pin-Jin Hu, Susan Hutfless
AIM: To investigate the differences in family history of inflammatory bowel disease (IBD) and clinical outcomes among individuals with Crohn's disease (CD) residing in China and the United States. METHODS: We performed a survey-based cross-sectional study of participants with CD recruited from China and the United States. We compared the prevalence of IBD family history and history of ileal involvement, CD-related surgeries and IBD medications in China and the United States, adjusting for potential confounders...
November 6, 2016: World Journal of Gastrointestinal Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27861795/sex-specific-mitonuclear-epistasis-and-the-evolution-of-mitochondrial-bioenergetics-ageing-and-life-history-in-seed-beetles
#16
Mirko Đorđević, Biljana Stojković, Uroš Savković, Elina Immonen, Nikola Tucić, Jelica Lazarević, Göran Arnqvist
The role of mitochondrial DNA for the evolution of life-history traits remains debated. We examined mitonuclear effects on the activity of the multisubunit complex of the electron transport chain (ETC) involved in oxidative phosphorylation (OXPHOS) across lines of the seed beetle Acanthoscelides obtectus selected for a short (E) or a long (L) life for more than >160 generations. We constructed and phenotyped mitonuclear introgression lines, which allowed us to assess the independent effects of the evolutionary history of the nuclear and the mitochondrial genome...
November 9, 2016: Evolution; International Journal of Organic Evolution
https://www.readbyqxmd.com/read/27847560/left-ventricular-false-tendons-and-electrocardiogram-repolarization-abnormalities-in-healthy-young-subjects
#17
Zlatan Lazarevic, Emanuela Ciminelli, Federico Quaranta, Fabio Sperandii, Emanuele Guerra, Fabio Pigozzi, Paolo Borrione
AIM: To describe echocardiographically left ventricular false tendon characteristics and the correlation with ventricular repolarization abnormalities in young athletes. METHODS: Three hundred and sixteen healthy young athletes from different sport disciplines were evaluated from 2009 to 2011 during routine screening for agonistic sports eligibility. All subjects, as part of standard pre-participation screening medical evaluation, underwent a basal and post step test 12-lead electrocardiogram (ECG)...
October 26, 2016: World Journal of Cardiology
https://www.readbyqxmd.com/read/27801678/histone-demethylase-jarid1c-inactivation-triggers-genomic-instability-in-sporadic-renal-cancer
#18
Beatrice Rondinelli, Dalia Rosano, Elena Antonini, Michela Frenquelli, Laura Montanini, DaChuan Huang, Simona Segalla, Kosuke Yoshihara, Samir B Amin, Dejan Lazarevic, Bin Tean The, Roel G W Verhaak, P Andrew Futreal, Luciano Di Croce, Lynda Chin, Davide Cittaro, Giovanni Tonon
No abstract text is available yet for this article.
November 1, 2016: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27801402/-supraorbital-keyhole-craniotomy-in-surgery-of-anterior-circle-of-willis-aneurysms
#19
R S Dzhindzhikhadze, O N Dreval', V A Lazarev, R L Kambiev
The progress in surgical treatment of intracranial aneurysms is based on the introduction of modern minimally invasive techniques. Among the variety of keyhole approaches, supraorbital craniotomy is most often used in surgical treatment of anterior circle of willis aneurysms. The authors present the preliminary results of application of supraorbital keyhole craniotomy for anterior circle of willis aneurysms in 27 patients. Most of the patients had unruptured aneurysms (18 patients). Nine patients had SAH, and 4 of them were operated on in the acute period...
2016: Zhurnal Voprosy Neĭrokhirurgii Imeni N. N. Burdenko
https://www.readbyqxmd.com/read/27797328/-conformational-polymorphysm-of-g-rich-fragments-of-dna-alu-repeats-i-potential-noncanonical-structures
#20
A V Sekridova, A M Varizhuk, O N Tatarinova, V V Severov, N A Barinov, I P Smirnov, V N Lazarev, D V Klinov, G E Pozmogova
In this paper, we report results of systematic studies of conformational polymorphism of G-rich DNA fragments from Alu repeats. Alu retrotransposones are primate-specific short interspersed elements. Using the Alu sequence from the prooncogen bcl2 intron and the consensus AluSx sequence as representative examples, we determined characteristic Alu sites that are capable of adopting G-quadruplex (GQ) conformations (i.e., potential quadruplex sites - PQSAlu), and demonstrated by bioinformatics methods that those sites are Alu-specific in the human genome...
July 2016: Biomedit︠s︡inskai︠a︡ Khimii︠a︡
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