keyword
MENU ▼
Read by QxMD icon Read
search

Belkaid

keyword
https://www.readbyqxmd.com/read/27799160/sensing-of-the-microbiota-by-nod1-in-mesenchymal-stromal-cells-regulates-murine-hematopoiesis
#1
Chiaki Iwamura, Nicolas Bouladoux, Yasmine Belkaid, Alan Sher, Dragana Jankovic
The microbiota are known to influence the generation of hematopoietic progenitors although the pathways underlying this process are still poorly understood. NOD1 and NOD2 are intracellular sensors for both Gram-positive and negative bacteria, but their role in steady-state hematopoiesis has never been characterized. We observed that stimulation with NOD1 or NOD2 ligand had no effect on the survival/proliferation of hematopoietic precursors. Nonetheless, NOD1 but not NOD2 ligand induced expression of multiple hematopoietic cytokines (IL-7, Flt3L, SCF, ThPO and IL-6) from bone marrow mesenchymal stromal cells (MSC) in vitro...
October 31, 2016: Blood
https://www.readbyqxmd.com/read/27716507/host-protozoan-interactions-protect-from-mucosal-infections-through-activation-of-the-inflammasome
#2
Aleksey Chudnovskiy, Arthur Mortha, Veronika Kana, Andrea Kennard, Juan David Ramirez, Adeeb Rahman, Romain Remark, Ilaria Mogno, Ruby Ng, Sasha Gnjatic, El-Ad David Amir, Alexander Solovyov, Benjamin Greenbaum, Jose Clemente, Jeremiah Faith, Yasmine Belkaid, Michael E Grigg, Miriam Merad
While conventional pathogenic protists have been extensively studied, there is an underappreciated constitutive protist microbiota that is an integral part of the vertebrate microbiome. The impact of these species on the host and their potential contributions to mucosal immune homeostasis remain poorly studied. Here, we show that the protozoan Tritrichomonas musculis activates the host epithelial inflammasome to induce IL-18 release. Epithelial-derived IL-18 promotes dendritic cell-driven Th1 and Th17 immunity and confers dramatic protection from mucosal bacterial infections...
October 6, 2016: Cell
https://www.readbyqxmd.com/read/27623245/linking-the-microbiota-chronic-disease-and-the-immune-system
#3
REVIEW
Timothy W Hand, Ivan Vujkovic-Cvijin, Vanessa K Ridaura, Yasmine Belkaid
Chronic inflammatory diseases (CIDs) are the most important causes of mortality in the world today and are on the rise. We now know that immune-driven inflammation is critical in the etiology of these diseases, though the environmental triggers and cellular mechanisms that lead to their development are still mysterious. Many CIDs are associated with significant shifts in the microbiota toward inflammatory configurations, which can affect the host both by inducing local and systemic inflammation and by alterations in microbiota-derived metabolites...
December 2016: Trends in Endocrinology and Metabolism: TEM
https://www.readbyqxmd.com/read/27565342/oxygen-sensing-by-t-cells-establishes-an-immunologically-tolerant-metastatic-niche
#4
David Clever, Rahul Roychoudhuri, Michael G Constantinides, Michael H Askenase, Madhusudhanan Sukumar, Christopher A Klebanoff, Robert L Eil, Heather D Hickman, Zhiya Yu, Jenny H Pan, Douglas C Palmer, Anthony T Phan, John Goulding, Luca Gattinoni, Ananda W Goldrath, Yasmine Belkaid, Nicholas P Restifo
Cancer cells must evade immune responses at distant sites to establish metastases. The lung is a frequent site for metastasis. We hypothesized that lung-specific immunoregulatory mechanisms create an immunologically permissive environment for tumor colonization. We found that T-cell-intrinsic expression of the oxygen-sensing prolyl-hydroxylase (PHD) proteins is required to maintain local tolerance against innocuous antigens in the lung but powerfully licenses colonization by circulating tumor cells. PHD proteins limit pulmonary type helper (Th)-1 responses, promote CD4(+)-regulatory T (Treg) cell induction, and restrain CD8(+) T cell effector function...
August 25, 2016: Cell
https://www.readbyqxmd.com/read/27432938/critical-role-of-fatty-acid-metabolism-in-ilc2-mediated-barrier-protection-during-malnutrition-and-helminth-infection
#5
Christoph Wilhelm, Oliver J Harrison, Vanessa Schmitt, Martin Pelletier, Sean P Spencer, Joseph F Urban, Michelle Ploch, Thirumalai R Ramalingam, Richard M Siegel, Yasmine Belkaid
Innate lymphoid cells (ILC) play an important role in many immune processes, including control of infections, inflammation, and tissue repair. To date, little is known about the metabolism of ILC and whether these cells can metabolically adapt in response to environmental signals. Here we show that type 2 innate lymphoid cells (ILC2), important mediators of barrier immunity, predominantly depend on fatty acid (FA) metabolism during helminth infection. Further, in situations where an essential nutrient, such as vitamin A, is limited, ILC2 sustain their function and selectively maintain interleukin 13 (IL-13) production via increased acquisition and utilization of FA...
July 25, 2016: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/27240414/metabolic-effect-of-estrogen-receptor-agonists-on-breast-cancer-cells-in-the-presence-or-absence-of-carbonic-anhydrase-inhibitors
#6
Anissa Belkaid, Miroslava Čuperlović-Culf, Mohamed Touaibia, Rodney J Ouellette, Marc E Surette
Metabolic shift is one of the major hallmarks of cancer development. Estrogen receptor (ER) activity has a profound effect on breast cancer cell growth through a number of metabolic changes driven by its effect on transcription of several enzymes, including carbonic anhydrases, Stearoyl-CoA desaturase-1, and oncogenes including HER2. Thus, estrogen receptor activators can be expected to lead to the modulation of cell metabolism in estrogen receptor positive cells. In this work we have investigated the effect of 17β-estradiol, an ER activator, and ferulic acid, a carbonic anhydrase inhibitor, as well as ER activator, in the absence and in the presence of the carbonic anhydrase inhibitor acetazolamide on the metabolism of MCF7 cells and MCF7 cells, stably transfected to express HER2 (MCF7HER2)...
2016: Metabolites
https://www.readbyqxmd.com/read/27231051/the-influence-of-skin-microorganisms-on-cutaneous-immunity
#7
Yasmine Belkaid, Samira Tamoutounour
The skin is a complex and dynamic ecosystem that is inhabited by many microorganisms. Recent evidence highlights the profound reliance of the skin immune system on its resident microbiota for both host defence and tissue repair. This tissue is also a primary target for infections, which are in some cases caused by normal constituents of the microbiota. In the context of infections and genetic predispositions that are associated with barrier or regulatory network defects, microorganism-induced inflammatory cycles can contribute to the initiation and/or amplification of skin disorders...
May 27, 2016: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/27062243/the-garp-latent-tgf-%C3%AE-1-complex-on-treg-cells-modulates-the-induction-of-peripherally-derived-treg-cells-during-oral-tolerance
#8
Justin P Edwards, Timothy W Hand, Denise Morais da Fonseca, Deborah D Glass, Yasmine Belkaid, Ethan M Shevach
Treg cells can secrete latent TGF-β1 (LTGF-β1), but can also utilize an alternative pathway for transport and expression of LTGF-β1 on the cell surface in which LTGF-β1 is coupled to a distinct LTGF-β binding protein termed glycoprotein A repetitions predominant (GARP)/LRRC32. The function of the GARP/LTGF-β1 complex has remained elusive. Here, we examine in vivo the roles of GARP and TGF-β1 in the induction of oral tolerance. When Foxp3(-) OT-II T cells were transferred to wild-type recipient mice followed by OVA feeding, the conversion of Foxp3(-) to Foxp3(+) OT-II cells was dependent on recipient Treg cells...
June 2016: European Journal of Immunology
https://www.readbyqxmd.com/read/27002848/erratum-group-3-innate-lymphoid-cells-continuously-require-the-transcription-factor-gata-3-after-commitment
#9
Chao Zhong, Kairong Cui, Christoph Wilhelm, Gangqing Hu, Kairui Mao, Yasmine Belkaid, Keji Zhao, Jinfang Zhu
No abstract text is available yet for this article.
April 2016: Nature Immunology
https://www.readbyqxmd.com/read/26784267/erratum-group-3-innate-lymphoid-cells-continuously-require-the-transcription-factor-gata-3-after-commitment
#10
Chao Zhong, Kairong Cui, Christoph Wilhelm, Gangqing Hu, Kairui Mao, Yasmine Belkaid, Keji Zhao, Jinfang Zhu
No abstract text is available yet for this article.
February 2016: Nature Immunology
https://www.readbyqxmd.com/read/26595886/group-3-innate-lymphoid-cells-continuously-require-the-transcription-factor-gata-3-after-commitment
#11
Chao Zhong, Kairong Cui, Christoph Wilhelm, Gangqing Hu, Kairui Mao, Yasmine Belkaid, Keji Zhao, Jinfang Zhu
The transcription factor GATA-3 is indispensable for the development of all innate lymphoid cells (ILCs) that express the interleukin 7 receptor α-chain (IL-7Rα). However, the function of low GATA-3 expression in committed group 3 ILCs (ILC3 cells) has not been identified. We found that GATA-3 regulated the homeostasis of ILC3 cells by controlling IL-7Rα expression. In addition, GATA-3 served a critical function in the development of the NKp46(+) ILC3 subset by regulating the balance between the transcription factors T-bet and RORγt...
February 2016: Nature Immunology
https://www.readbyqxmd.com/read/26584514/withdrawn-design-and-implementation-of-a-high-performance-technique-for-tracking-photovoltaic-peak-power
#12
Abdelhakim Belkaid, Abdelhalim Kessal, Jean-Paul Gaubert, Ahmed Gherbi
No abstract text is available yet for this article.
January 2016: ISA Transactions
https://www.readbyqxmd.com/read/26451485/microbiota-dependent-sequelae-of-acute-infection-compromise-tissue-specific-immunity
#13
Denise Morais da Fonseca, Timothy W Hand, Seong-Ji Han, Michael Y Gerner, Arielle Glatman Zaretsky, Allyson L Byrd, Oliver J Harrison, Alexandra M Ortiz, Mariam Quinones, Giorgio Trinchieri, Jason M Brenchley, Igor E Brodsky, Ronald N Germain, Gwendalyn J Randolph, Yasmine Belkaid
Infections have been proposed as initiating factors for inflammatory disorders; however, identifying associations between defined infectious agents and the initiation of chronic disease has remained elusive. Here, we report that a single acute infection can have dramatic and long-term consequences for tissue-specific immunity. Following clearance of Yersinia pseudotuberculosis, sustained inflammation and associated lymphatic leakage in the mesenteric adipose tissue deviates migratory dendritic cells to the adipose compartment, thereby preventing their accumulation in the mesenteric lymph node...
October 8, 2015: Cell
https://www.readbyqxmd.com/read/26294403/in-vitro-analyses-of-t-cell-effector-differentiation
#14
Elizabeth A Wohlfert, Andrea C Carpenter, Yasmine Belkaid, Rémy Bosselut
In vitro culture is an important complement, or substitute, to in vivo approaches in order to study T cell effector differentiation. Here, we describe culture conditions that generate specific effector cell types by exposing naïve T cells to appropriate cytokine signals.
2016: Methods in Molecular Biology
https://www.readbyqxmd.com/read/26070484/bone-marrow-resident-nk-cells-prime-monocytes-for-regulatory-function-during-infection
#15
Michael H Askenase, Seong-Ji Han, Allyson L Byrd, Denise Morais da Fonseca, Nicolas Bouladoux, Christoph Wilhelm, Joanne E Konkel, Timothy W Hand, Norinne Lacerda-Queiroz, Xin-zhuan Su, Giorgio Trinchieri, John R Grainger, Yasmine Belkaid
Tissue-infiltrating Ly6C(hi) monocytes play diverse roles in immunity, ranging from pathogen killing to immune regulation. How and where this diversity of function is imposed remains poorly understood. Here we show that during acute gastrointestinal infection, priming of monocytes for regulatory function preceded systemic inflammation and was initiated prior to bone marrow egress. Notably, natural killer (NK) cell-derived IFN-γ promoted a regulatory program in monocyte progenitors during development. Early bone marrow NK cell activation was controlled by systemic interleukin-12 (IL-12) produced by Batf3-dependent dendritic cells (DCs) in the mucosal-associated lymphoid tissue (MALT)...
June 16, 2015: Immunity
https://www.readbyqxmd.com/read/26022099/17%C3%AE-estradiol-induces-stearoyl-coa-desaturase-1-expression-in-estrogen-receptor-positive-breast-cancer-cells
#16
Anissa Belkaid, Sabrina R Duguay, Rodney J Ouellette, Marc E Surette
BACKGROUND: To sustain cell growth, cancer cells exhibit an altered metabolism characterized by increased lipogenesis. Stearoyl-CoA desaturase-1 (SCD-1) catalyzes the production of monounsaturated fatty acids that are essential for membrane biogenesis, and is required for cell proliferation in many cancer cell types. Although estrogen is required for the proliferation of many estrogen-sensitive breast carcinoma cells, it is also a repressor of SCD-1 expression in liver and adipose. The current study addresses this apparent paradox by investigating the impact of estrogen on SCD-1 expression in estrogen receptor-α-positive breast carcinoma cell lines...
2015: BMC Cancer
https://www.readbyqxmd.com/read/26018935/enhanced-t-cell-activation-and-differentiation-in-lymphocytes-from-transgenic-mice-expressing-ubiquitination-resistant-2kr-lat-molecules
#17
A B Rodriguez-Peña, J Gomez-Rodriguez, R L Kortum, D C Palmer, Z Yu, G C Guittard, E A Wohlfert, P B Silver, J A Misplon, C L Sommers, L Feigenbaum, S L Epstein, R R Caspi, Y Belkaid, N P Restifo, L E Samelson, L Balagopalan
Linker for activation of T cells (LAT) is critical for the propagation of T-cell signals upon T-cell receptor (TCR) activation. Previous studies demonstrated that substitution of LAT lysines with arginines (2KR LAT) resulted in decreased LAT ubiquitination and elevated T-cell signaling, indicating that LAT ubiquitination is a molecular checkpoint for attenuation of T-cell signaling. To investigate the role of LAT ubiquitination in vivo, we have generated transgenic mice expressing WT and ubiquitin-defective 2KR LAT...
October 2015: Gene Therapy
https://www.readbyqxmd.com/read/25860600/gut-microbiota-the-link-to-your-second-brain
#18
COMMENT
Vanessa Ridaura, Yasmine Belkaid
Serotonin is a highly ubiquitous signaling molecule that plays a role in the regulation of various physiological functions. Several lines of evidence, including the present work from Hsiao and colleagues, demonstrate that, in the gut, microbial-derived metabolites affect the production of serotonin that in turn impacts host physiological functions.
April 9, 2015: Cell
https://www.readbyqxmd.com/read/25539086/commensal-dendritic-cell-interaction-specifies-a-unique-protective-skin-immune-signature
#19
Shruti Naik, Nicolas Bouladoux, Jonathan L Linehan, Seong-Ji Han, Oliver J Harrison, Christoph Wilhelm, Sean Conlan, Sarah Himmelfarb, Allyson L Byrd, Clayton Deming, Mariam Quinones, Jason M Brenchley, Heidi H Kong, Roxanne Tussiwand, Kenneth M Murphy, Miriam Merad, Julia A Segre, Yasmine Belkaid
The skin represents the primary interface between the host and the environment. This organ is also home to trillions of microorganisms that play an important role in tissue homeostasis and local immunity. Skin microbial communities are highly diverse and can be remodelled over time or in response to environmental challenges. How, in the context of this complexity, individual commensal microorganisms may differentially modulate skin immunity and the consequences of these responses for tissue physiology remains unclear...
April 2, 2015: Nature
https://www.readbyqxmd.com/read/25414304/dialogue-between-skin-microbiota-and-immunity
#20
REVIEW
Yasmine Belkaid, Julia A Segre
Human skin, the body's largest organ, functions as a physical barrier to bar the entry of foreign pathogens, while concomitantly providing a home to myriad commensals. Over a human's life span, keratinized skin cells, immune cells, and microbes all interact to integrate the processes of maintaining skin's physical and immune barrier under homeostatic healthy conditions and also under multiple stresses, such as wounding or infection. In this Review, we explore the intricate interactions of microbes and immune cells on the skin surface and within associated appendages to regulate this orchestrated maturation in the context of both host physiological changes and environmental challenges...
November 21, 2014: Science
keyword
keyword
32020
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"