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https://www.readbyqxmd.com/read/29786957/statistical-approaches-to-adjusting-weights-for-dependent-arms-in-network-meta-analysis
#1
Yu-Xuan Su, Yu-Kang Tu
Network meta-analysis compares multiple treatments in terms of their efficacy and harm by including evidence from randomized controlled trials. Most clinical trials use parallel design, where patients are randomly allocated to different treatments and receive only one treatment. However, some trials use within person designs such as split-body, split-mouth and cross-over designs, where each patient may receive more than one treatment. Data from treatment arms within these trials are no longer independent, so the correlations between dependent arms need to be accounted for within the statistical analyses...
May 22, 2018: Research Synthesis Methods
https://www.readbyqxmd.com/read/29786874/meta-analysis-of-the-association-of-alcohol-related-social-media-use-with-alcohol-consumption-and-alcohol-related-problems-in-adolescents-and-young-adults
#2
REVIEW
Brenda L Curtis, Samantha J Lookatch, Danielle E Ramo, James R McKay, Richard S Feinn, Henry R Kranzler
Despite the pervasive use of social media by young adults, there is comparatively little known about whether, and how, engagement in social media influences this group's drinking patterns and risk of alcohol-related problems. We examined the relations between young adults' alcohol-related social media engagement (defined as the posting, liking, commenting, and viewing of alcohol-related social media content) and their drinking behavior and problems. We conducted a systematic review and meta-analysis of studies evaluating the association of alcohol consumption and alcohol-related problems with alcohol-related social media engagement...
May 22, 2018: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29786871/gender-specific-effects-of-selection-for-drinking-in-the-dark-on-the-network-roles-of-coding-and-non-coding-rnas
#3
Ovidiu Dan Iancu, Alex Colville, Beth Wilmot, Robert Searles, Priscila Darakjian, Christina Zheng, Shannon McWeeney, Sunita Kawane, John C Crabbe, Pamela Metten, Denesa Oberbeck, Robert Hitzemann
BACKGROUND: Transcriptional differences between Heterogeneous stock (HS/NPT) mice and High Drinking in the Dark (HDID) selected mouse lines have previously been described based on microarray technology coupled with network based analysis (Iancu et al., 2013b). The network changes were reproducible in two independent selections and largely confined to two distinct network modules; in contrast differential expression appeared more specific to each selected line. The current study extends these results by utilizing RNA-Seq technology, allowing evaluation of the relationship between genetic risk and transcription of non-coding RNA; we additionally evaluate sex-specific transcriptional effects of selection...
May 22, 2018: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29786833/assessment-of-cerebral-perfusion-and-edema-in-preeclampsia-with-intravoxel-incoherent-motion-mri
#4
Maria Nelander, Daniel Hannsberger, Inger Sundström-Poromaa, Lina Bergman, Jan Weis, Helena Åkerud, Johan Wikström, Anna-Karin Wikström
INTRODUCTION: Cerebral complications are the main reasons for morbidity and mortality in preeclampsia and eclampsia. Still we do not know if the pathophysiology entails hypo- or hyperperfusion of the brain, or how and when edema emerges, due to the difficulty to examine the cerebral circulation. MATERIAL AND METHODS: We have used a non-invasive diffusion weighted magnetic resonance imaging (MRI) technique, intravoxel incoherent motion, to study cerebral perfusion on the capillary level and cerebral edema in women with preeclampsia (n=30), normal pregnancy (n=32) and non-pregnant women (n=16)...
May 22, 2018: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/29786824/intramedullary-nail-with-integrated-cephalocervical-screws-in-the-intertrochanteric-fractures-treatment-position-of-screws-in-fracture-stability
#5
Gökhan Kaynak, Mehmet Can Ünlü, Mehmet Fatih Güven, Ozan Ali Erdal, Okan Tok, Hüseyin Botanlıoğlu, Önder Aydıngöz
BACKGROUND: Stable fracture fixation is important in the treatment of intertrochanteric femur (ITF) fractures in the elderly population to prevent the loss of reduction, achieve early mobility, and restore independence. The aim of this study was to present the results of surgical treatment of stable and unstable ITF fractures using a trochanteric antegrade intramedullary nail with two cephalocervical screws in an integrated mechanism (Intertan®; Smith & Nephew, Memphis, TN) and evaluate the relationship between the loss of reduction and screw position in the femoral neck in two planes...
May 2018: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/29786823/application-of-hybrid-external-fixation-by-the-joystick-method-in-bicondylar-tibial-plateau-fractures-technical-note
#6
Ersin Kuyucu, Adnan Kara, Ferhat Say, Mehmet Erdil, Murat Bülbül, Barış Gülenç
BACKGROUND: This study aimed to present clinical outcomes in patients with tibial plateau fractures who were treated with hybrid external fixators and describe the details of our technique. Schanz screws were synchronously applied and used as a joystick for fracture reduction. METHODS: The study population included 72 patients with bicondylar tibial plateau fractures classified as type 41-C2 according to the AO classification. Joint reduction was maintained using Schanz screws transmitted through tibial condyles as a joystick under fluoroscopy...
May 2018: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/29786767/oral-supplementation-of-lanthanum-zirconate-nanoparticles-moderately-affected-behavior-but-drastically-disturbed-leukocyte-count-serum-cholesterol-levels-and-antioxidant-parameters-from-vital-organs-of-albino-mice-in-a-gender-specific-manner
#7
Muhammad Nazar Aftab, Irum Naz Akram, Tafheem Khosa, Syeda Qandeel Zahra, Irum Bashir, Muhammad Naeem Ashiq, Furhan Iqbal
Lanthanum Zirconate nanoparticles (NPs) are used in blades of gas turbine engines to thermally insulate them and to protect them against hot and corrosive gas streams. However, the information regarding their biocompatibility is limited. The present study was aimed to report the effect of Lanthanum Zirconate NPs on selected aspects of behavior, serum biochemistry, complete blood count and antioxidant parameters from vital organs of albino mice in a gender specific manner. Albino mice, seven weeks old, were orally treated with 75 mg/ml solvent/Kg body weight of Lanthanum Zirconate nanoparticles for consecutive 22 days...
May 21, 2018: Metabolic Brain Disease
https://www.readbyqxmd.com/read/29786765/analysis-of-streptomyces-ghanaensis-atcc14672-gene-ssfg_07725-for-putative-%C3%AE-butyrolactone-synthase
#8
Yuriy Kuzhyk, Halyna Mutenko, Victor Fedorenko, Bohdan Ostash
Low molecular weight signaling compounds (LMWC) are important players in regulating various aspects of Streptomyces biology. Their exact roles in certain strain will ultimately depend on overall configuration of regulatory network and thus cannot be predicted on basis of in silico studies. Here, we explored S. ghanaensis gene SSFG_07725 (afsA gh ) presumably involved in initial steps of formation of γ-butyrolactone LMWC. Disruption of afsA gh impaired aerial mycelium formation and increased the transcription of pleiotropic regulatory gene adpA gh , whereas level of moenomycin production remained virtually unaffected...
May 21, 2018: Folia Microbiologica
https://www.readbyqxmd.com/read/29786675/combined-effectiveness-of-honey-and-immunonutrition-on-bacterial-translocation-secondary-to-obstructive-jaundice-in-rats-experimental-study
#9
Serhat Oguz, Omer Salt, Abdil C Ibis, Saban Gurcan, Dogan Albayrak, Tulin Yalta, Tamer Sagiroglu, Cengiz Erenoglu
BACKGROUND Obstructive jaundice is a serious, life-threatening condition that can lead to death as a result of sepsis and multiorgan failure due to bacterial translocation. Treatment should be started as soon as possible after diagnosis. MATERIAL AND METHODS Forty 24-week-old male Sprague Dawley rats, with an average weight of 250 g to 300 g, were included in this study. The rats were randomly placed into five groups, each group consisted of eight rats. The sham group underwent only common bile duct (CBD) dissection and no ligation was performed...
May 22, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29786674/choline-supplementation-prevents-a-hallmark-disturbance-of-kwashiorkor-in-weanling-mice-fed-a-maize-vegetable-diet-hepatic-steatosis-of-undernutrition
#10
Thaddaeus May, Kevin C Klatt, Jacob Smith, Eumenia Castro, Mark Manary, Marie A Caudill, Farook Jahoor, Marta L Fiorotto
Hepatic steatosis is a hallmark feature of kwashiorkor malnutrition. However, the pathogenesis of hepatic steatosis in kwashiorkor is uncertain. Our objective was to develop a mouse model of childhood undernutrition in order to test the hypothesis that feeding a maize vegetable diet (MVD), like that consumed by children at risk for kwashiorkor, will cause hepatic steatosis which is prevented by supplementation with choline. A MVD was developed with locally sourced organic ingredients, and fed to weanling mice ( n = 9) for 6 or 13 days...
May 22, 2018: Nutrients
https://www.readbyqxmd.com/read/29786667/mass-transfer-in-osmotic-dehydration-of-kiwiberry-experimental-and-mathematical-modelling-studies
#11
Michał Bialik, Artur Wiktor, Piotr Latocha, Ewa Gondek
The aim of this study was to analyze the impact of osmotic solutions and temperature on the osmotic dehydration (OD) of two cultivars of kiwiberry. OD was carried out in sucrose, xylitol and maltitol solutions at 30 °C and 50 °C, respectively. The process of osmotic dehydration was described by the means of water loss (WL), solid gain (SG), weight reduction (WR), and water content changes. Moreover, dehydration was described by mathematical models often used in the literature. The highest WL, WR and SG values were observed for samples treated by xylitol and maltitol at 50 °C...
May 22, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29786658/melatonin-as-a-therapy-for-traumatic-brain-injury-a-review-of-published-evidence
#12
REVIEW
Nicole Osier, Emily McGreevy, Lan Pham, Ava Puccio, Dianxu Ren, Yvette P Conley, Sheila Alexander, C Edward Dixon
Melatonin (MEL) is a hormone that is produced in the brain and is known to bind to MEL-specific receptors on neuronal membranes in several brain regions. MEL's documented neuroprotective properties, low toxicity, and ability to cross the blood-brain-barrier have led to its evaluation for patients with traumatic brain injury (TBI), a condition for which there are currently no Food and Drug Administration (FDA)-approved therapies. The purpose of this manuscript is to summarize the evidence surrounding the use of melatonin after TBI, as well as identify existing gaps and future directions...
May 22, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29786653/role-for-cystathionine-%C3%AE-lyase-cse-in-an-ethanol-e-induced-lesion-in-fetal-brain-gsh-homeostasis
#13
Dhyanesh Patel, Marylatha Rathinam, Courtney Jarvis, Lenin Mahimainathan, George Henderson, Madhusudhanan Narasimhan
Earlier, we reported that gestational ethanol (E) can dysregulate neuron glutathione (GSH) homeostasis partially via impairing the EAAC1-mediated inward transport of Cysteine (Cys) and this can affect fetal brain development. In this study, we investigated if there is a role for the transulfuration pathway (TSP), a critical bio-synthetic point to supply Cys in E-induced dysregulation of GSH homeostasis. These studies utilized an in utero E binge model where the pregnant Sprague⁻Dawley (SD) rat dams received five doses of E at 3...
May 22, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29786649/kudzu-leaf-extract-suppresses-the-production-of-inducible-nitric-oxide-synthase-cyclooxygenase-2-tumor-necrosis-factor-alpha-and-interleukin-6-via-inhibition-of-jnk-tbk1-and-stat1-in-inflammatory-macrophages
#14
Seok Hyun Eom, So-Jung Jin, Hee-Yeong Jeong, Youngju Song, You Jin Lim, Jong-In Kim, Youn-Hyung Lee, Hee Kang
Kudzu ( Pueraria montana var. lobata (Willd.) Sanjappa & Pradeep) is a perennial leguminous vine, and its root and flower have been used for herbal medicine in Asia for a long time. Most dietary flavonoids are reported to be concentrated in its root, not in its aerial parts including leaves. In this study, we investigated whether kudzu leaf and its major constituent, robinin (kaempferol-3- O -robinoside-7- O -rhanmoside) possessed anti-inflammatory activity. To test this hypothesis, we used peritoneal macrophages isolated from BALB/c mice and stimulated the cells with lipopolysaccharide (LPS) or LPS plus interferon (IFN)-γ...
May 22, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29786646/metabolic-reprogramming-by-3-iodothyronamine-t1am-a-new-perspective-to-reverse-obesity-through-co-regulation-of-sirtuin-4-and-6-expression
#15
Fariba M Assadi-Porter, Hannah Reiland, Martina Sabatini, Leonardo Lorenzini, Vittoria Carnicelli, Micheal Rogowski, Ebru S Selen Alpergin, Marco Tonelli, Sandra Ghelardoni, Alessandro Saba, Riccardo Zucchi, Grazia Chiellini
Obesity is a complex disease associated with environmental and genetic factors. 3-Iodothyronamine (T1AM) has revealed great potential as an effective weight loss drug. We used metabolomics and associated transcriptional gene and protein expression analysis to investigate the tissue specific metabolic reprogramming effects of subchronic T1AM treatment at two pharmacological daily doses (10 and 25 mg/kg) on targeted metabolic pathways. Multi-analytical results indicated that T1AM at 25 mg/kg can act as a novel master regulator of both glucose and lipid metabolism in mice through sirtuin-mediated pathways...
May 22, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29786631/comparison-between-elite-and-subelite-swimmers-on-dry-land-and-tumble-turn-leg-extensor-force-time-characteristics
#16
Julian V Jones, David B Pyne, G Greg Haff, Robert U Newton
Jones, JV, Pyne, DB, Haff, GG, and Newton, RU. Comparison between elite and subelite swimmers on dry land and tumble turn leg extensor force-time characteristics. J Strength Cond Res 32(6): 1762-1769, 2018-Elite swimmers demonstrate faster swimming turn times that are potentially a result of having better strength-power characteristics than subelite swimmers. We quantified differences between dry-land and swimming turn force-time characteristics in elite swimmers and subelite swimmers. Subelite (11 males: 17...
June 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29786491/validation-of-pi-rads-version-2-in-transition-zone-lesions-for-the-detection-of-prostate-cancer
#17
Janice N Thai, Harish A Narayanan, Arvin K George, M Minhaj Siddiqui, Parita Shah, Francesca V Mertan, Maria J Merino, Peter A Pinto, Peter L Choyke, Bradford J Wood, Baris Turkbey
Purpose To determine the association between Prostate Imaging Reporting and Data System (PI-RADS) version 2 scores and prostate cancer (PCa) in a cohort of patients undergoing biopsy of transition zone (TZ) lesions. Materials and Methods A total of 634 TZ lesions in 457 patients were identified from a prospectively maintained database of consecutive patients undergoing prostate magnetic resonance imaging. Prostate lesions were retrospectively categorized with the PI-RADS version 2 system by two readers in consensus who were blinded to histopathologic findings...
May 18, 2018: Radiology
https://www.readbyqxmd.com/read/29786490/gallium-68-psma-11-pet-mr-imaging-in-patients-with-intermediate-or-high-risk-prostate-cancer
#18
Sonya Youngju Park, Claudia Zacharias, Caitlyn Harrison, Richard E Fan, Christian Kunder, Negin Hatami, Frederik Giesel, Pejman Ghanouni, Bruce Daniel, Andreas M Loening, Geoffrey A Sonn, Andrei Iagaru
Purpose To report the results of dual-time-point gallium 68 (68 Ga) prostate-specific membrane antigen (PSMA)-11 positron emission tomography (PET)/magnetic resonance (MR) imaging prior to prostatectomy in patients with intermediate- or high-risk cancer. Materials and Methods Thirty-three men who underwent conventional imaging as clinically indicated and who were scheduled for radical prostatectomy with pelvic lymph node dissection were recruited for this study. A mean dose of 4.1 mCi ± 0.7 (151.7 MBq ± 25...
May 16, 2018: Radiology
https://www.readbyqxmd.com/read/29786487/diffusion-weighted-mri-is-superior-to-pet-ct-in-predicting-survival-of-patients-undergoing-90-y-radioembolization-of-hepatic-metastases
#19
Alexandra Barabasch, Alexander Heinzel, Philipp Bruners, Nils A Kraemer, Christiane K Kuhl
Purpose To determine the relationship between diffusion-weighted (DW) liver MR images obtained 4-6 weeks after lobar yttrium 90 (90 Y) treatment and overall survival in comparison with PET/CT or established oncologic factors known to affect survival. Materials and Methods The institutional review board approved this prospective intraindividual comparative study in 36 consecutive patients (25 women) with liver-dominant metastases (20 colorectal, 14 breast, two other) (mean age, 60 years ± 10 [standard deviation]) who underwent fluorine 18 (18 F) fluorodeoxyglucose (FDG) PET/CT and DW MRI before and 4-6 weeks after 90 Y radioembolization...
May 21, 2018: Radiology
https://www.readbyqxmd.com/read/29786486/one-year-retention-of-gadolinium-in-the-brain-comparison-of-gadodiamide-and-gadoterate-meglumine-in-a-rodent-model
#20
Philippe Robert, Stefanie Fingerhut, Cécile Factor, Véronique Vives, Justine Letien, Michael Sperling, Marlène Rasschaert, Robin Santus, Sébastien Ballet, Jean-Marc Idée, Claire Corot, Uwe Karst
Purpose To compare the long-term brain elimination kinetics and gadolinium species in healthy rats after repeated injections of the contrast agents gadodiamide (a linear contrast agent) or gadoterate (a macrocyclic contrast agent). Materials and Methods Nine-week-old rats received five doses of 2.4 mmol gadolinium per kilogram of body weight over 5 weeks and were followed for 12 months with T1-weighted MRI (n = 140 rats, corresponding to seven time points, two contrast agents, and 10 rats per group). Animals were sacrificed at 1 week, 1 month, and 2, 3, 4, 5, and 12 months after the last injection...
May 17, 2018: Radiology
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