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JOURNAL ARTICLE
Mohamed A Farrag, Ibrahim M Aziz, Asma N Alsaleh, Fahad N Almajhdi
Respiratory tract infections due to a variety of viruses continue to threaten the human population worldwide, particularly in developing countries. Among the responsible viruses, Human Bocavirus (HBoV), a novel discovered virus, causes respiratory tract and gastroenteritis disorders in young children. In Saudi Arabia, data regarding virus molecular epidemiology and evolution and its implication in respiratory tract infection are scarce. In the current study, genetic diversity and circulation pattern of HBoV-1 among hospitalized children due to acute respiratory tract infection (ARTI) during two consecutive years were charted...
April 15, 2024: Heliyon
#22
REVIEW
Anindita Ghosh, Arti Muley, Archana S Ainapure, Aditi R Deshmane, Anu Mahajan
Worldwide, diabetic nephropathy (DN) is a significant contributor to end-stage renal failure and chronic kidney disease. Probiotic supplementation has recently gained popularity as a potential nutritional therapy in several clinical trials aimed at improving renal function, inflammation, oxidative stress, dyslipidemia, glycemic control, and inflammation. However, they still need to undergo a thorough assessment of DN. It is crucial that the optimal dosage, duration, and combination of probiotic strains administered for the purpose of slowing down the advancement of DN be assessed...
February 2024: Curēus
#23
JOURNAL ARTICLE
Namita Das Saha, Priyanka Kumari, Bappa Das, R N Sahoo, Rajesh Kumar, Debasish Golui, Bhupinder Singh, Niveta Jain, Arti Bhatia, Anita Chaudhary, Bidisha Chakraborty, Arpan Bhowmik, Partha Saha, Sadikul Islam
Microplastics (MPs) is the second most important environmental issue and can potentially enter into food chain through farmland contamination and other means. There are no standardized extraction methods for quantification of MPs in soil. The embedded errors and biases generated serious problems regarding the comparability of different studies and leading to erroneous estimation. To address this gap, present study was formulated to develop an efficient method for MPs analysis suitable for a wide range of soil and organic matrices...
March 28, 2024: Science of the Total Environment
#24
JOURNAL ARTICLE
Vishnu Teja Obulareddy, Arti Dixit, Violeta Takhellambam, Rajnish K Verma, Deepyanti, Sandeep Kumar, Amit Kumar
BACKGROUND: Implant-supported restorations have gained popularity in modern dentistry, and the choice of abutment material is crucial for their long-term success. This in vitro study aimed to evaluate the fracture resistance and failure mode of implant-supported restorations using different abutment materials. METHODS: Ninety standardized implant-supported restorations were included in the study. Abutments made of titanium, zirconia, and a hybrid material (titanium base with a zirconia veneer) were evaluated...
February 2024: Curēus
#25
REVIEW
Recent Advances in Graphene-Enabled Materials for Photovoltaic Applications: A Comprehensive Review.
Pragyan Jain, R S Rajput, Sunil Kumar, Arti Sharma, Akshay Jain, Bhaskor Jyoti Bora, Prabhakar Sharma, Raman Kumar, Mohammad Shahid, Ali A Rajhi, Majed Alsubih, Mohd Asif Shah, Abhijit Bhowmik
Graphene's two-dimensional structural arrangement has sparked a revolutionary transformation in the domain of conductive transparent devices, presenting a unique opportunity in the renewable energy sector. This comprehensive Review critically evaluates the most recent advances in graphene production and its employment in solar cells, focusing on dye-sensitized, organic, and perovskite devices for bulk heterojunction (BHJ) designs. This comprehensive investigation discovered the following captivating results: graphene integration resulted in a notable 20...
March 19, 2024: ACS Omega
#26
JOURNAL ARTICLE
Hitender Gautam, Shahid Raza, Jaya Biswas, Sarita Mohapatra, Seema Sood, Benu Dhawan, Arti Kapil, Bimal K Das
PURPOSE: Drug-resistant Acinetobacter baumannii is an emerging threat. This study has been conducted to observe the efficacy of eravacycline along with the RND-efflux pump system. METHODS: A cross-sectional study was done collecting 48 clinical isolates of Acinetobacter baumannii. MICs of 15 antibiotics were detected along with BMD of tigecycline and eravacycline. PCR products of drug-resistant regulatory genes were sequenced and analyzed. RESULTS: Of the total 48 Isolates, 35 (72...
March 22, 2024: Indian Journal of Medical Microbiology
#27
JOURNAL ARTICLE
Fred Stephen Sarfo, Osahon Jeffery Asowata, Onoja Matthew Akpa, Joshua Akinyemi, Kolawole Wahab, Arti Singh, Albert Akpalu, Priscilla Abrafi Opare-Addo, Akinkunmi Paul Okekunle, Godwin Ogbole, Adekunle Fakunle, Oladimeji Adebayo, Reginald Obiako, Cynthia Akisanya, Morenkeji Komolafe, Taiwo Olunuga, Innocent I Chukwuonye, Godwin Osaigbovo, Paul Olowoyo, Phillip B Adebayo, Carolyn Jenkins, Abiodun Bello, Ruth Laryea, Phillip Ibinaye, Olatundun Olalusi, Sunday Adeniyi, Oyedunni Arulogun, Okechukwu Ogah, Abiodun Adeoye, Dialla Samuel, Benedit Calys-Tagoe, Hemant Tiwari, Onyemelukwe Obiageli, Yaw Mensah, Lambert Appiah, Rufus Akinyemi, Bruce Ovbiagele, Mayowa Owolabi
BACKGROUND: Hypertension is preeminent among the vascular risk factors for stroke occurrence. The wide gaps in awareness, detection, treatment, and control rates of hypertension are fueling an epidemic of stroke in sub-Saharan Africa. PURPOSE: To quantify the contribution of untreated, treated but uncontrolled, and controlled hypertension to stroke occurrence in Ghana and Nigeria. METHODS: The Stroke Investigative Research and Educational Network (SIREN) is a case-control study across 16 study sites in Ghana and Nigeria...
March 17, 2024: Journal of the Neurological Sciences
#28
JOURNAL ARTICLE
Rakshit Manhas, Arti Rathore, Ujwal Havelikar, Shavi Mahajan, Sumit G Gandhi, Avisek Mahapa
Antimicrobial resistance has emerged as a covert global health crisis, posing a significant threat to humanity. If left unaddressed, it is poised to become the foremost cause of mortality worldwide. Among the multitude of resistant bacterial pathogens, Pseudomonas aeruginosa, a Gram-negative, facultative bacterium, has been responsible for mild to deadly infections. It is now enlisted as a global critical priority pathogen by WHO. Urgent measures are required to combat this formidable pathogen, necessitating the development of novel anti-pseudomonal drugs...
March 21, 2024: Journal of Antibiotics
#29
JOURNAL ARTICLE
Aditi R Deshmane, Arti S Muley
AIM: To understand the association between macronutrient composition of a diet with Time in Range (TIR), Time above Range (TAR) and Time below Range (TBR) derived using a Continuous Glucose Monitoring (CGM) device for 14 days. METHODOLOGY: An exploratory analysis on the baseline data of 50 Type 2 Diabetes Mellitus participants with age 25-55 years, HbA1c upto 8% and on Metformin only) enrolled for an interventional clinical trial was performed. RESULTS: Participants consuming adequate carbohydrates (CHO) of 55 to 60% of total calories had better Average Blood Glucose of 142...
March 21, 2024: Endocrine
#30
JOURNAL ARTICLE
Arti Gupta, Mukesh Tripathi, Bari Siddiqui Ma, Desai V Sripad, Vamsikrishna Reddy K, Desu Rama Mohan, Prudhvinath A Reddy, Rakesh Upparakadiyala
INTRODUCTION: Exposure to lead in excess of the permissible limit is a known risk factor leading to preventable morbidity. The present study aimed to assess whether there is a change in the neurological and renal parameters among adults with blood lead levels (BLLs) higher than recommended at baseline and after prevention among differently exposed adults. METHODOLOGY: In the Guntur District of Andhra Pradesh, India, a cohort study was carried out in 2022-2023 among 180 adult males and females aged 20 to 60 years in three groups: direct occupational exposure, indirect occupational exposure, and no occupational exposure...
February 2024: Curēus
#31
Min Fang, Ling-Yao Kong, Guang-He Ji, Feng-Lan Pu, You-Zhu Su, Yu-Fei Li, Michael Moore, Merlin Willcox, Jeanne Trill, Xiao-Yang Hu, Jian-Ping Liu
Background: Acute respiratory tract infections (ARTIs) are the most common cause of morbidity and mortality worldwide, with most people experiencing at least one episode per year. Current treatment options are mainly symptomatic therapy. Antivirals, antibiotics, and glucocorticoids are of limited benefit for most infections. Traditional Chinese medicine has shown potential benefits in the treatment of ARTIs. Objective: The objective of this study was to determine the efficacy, effectiveness, and safety of Phragmites communis Trin...
2024: Frontiers in Pharmacology
#32
REVIEW
Vimal Kumar, Arti Barwal, Nitin Sharma, Danish Shafi Mir, Pradeep Kumar, Vikas Kumar
Proteins are considered magic molecules due to their enormous applications in the health sector. Over the past few decades, therapeutic proteins have emerged as a promising treatment option for various diseases, particularly cancer, cardiovascular disease, diabetes, and others. The formulation of protein-based therapies is a major area of research, however, a few factors still hinder the large-scale production of these therapeutic products, such as stability, heterogenicity, immunogenicity, high cost of production, etc...
April 2024: 3 Biotech
#33
JOURNAL ARTICLE
Arti Srivastava, Shankar Nalroad Sundararaj, Jagriti Bhatia, Dharamvir Singh Arya
Infectious diseases are a cause of major concern in this twenty-first century. There have been reports of various outbreaks like severe acute respiratory syndrome (SARS) in 2003, swine flu in 2009, Zika virus disease in 2015, and Middle East Respiratory Syndrome (MERS) in 2012, since the start of this millennium. In addition to these outbreaks, the latest infectious disease to result in an outbreak is the SARS-CoV-2 infection. A viral infection recognized as a respiratory illness at the time of emergence, SARS-CoV-2 has wreaked havoc worldwide because of its long-lasting implications like heart failure, sepsis, organ failure, etc...
March 18, 2024: Cytokine
#34
JOURNAL ARTICLE
Mohammad Arifuzzaman, Tae Hyung Won, Hiroshi Yano, Jazib Uddin, Elizabeth R Emanuel, Elin Hu, Wen Zhang, Ting-Ting Li, Wen-Bing Jin, Alex Grier, Sanchita Kashyap, Chun-Jun Guo, Frank C Schroeder, David Artis
Innate lymphoid cells (ILCs) can promote host defense, chronic inflammation, or tissue protection and are regulated by cytokines and neuropeptides. However, their regulation by diet and microbiota-derived signals remains unclear. We show that an inulin fiber diet promotes Tph1-expressing inflammatory ILC2s (ILC2INFLAM) in the colon, which produce IL-5 but not tissue-protective amphiregulin (AREG), resulting in the accumulation of eosinophils. This exacerbates inflammation in a murine model of intestinal damage and inflammation in an ILC2- and eosinophil-dependent manner...
May 6, 2024: Journal of Experimental Medicine
#35
Katherine L Duval, Ashley R Artis, Mary G Goll
The structural organization of eukaryotic genomes is contingent upon the fractionation of DNA into transcriptionally active euchromatin and repressive heterochromatin. However, we have a limited understanding of how these distinct states are first established during animal embryogenesis. Histone 3 lysine 9 trimethylation (H3K9me3) is critical to heterochromatin formation and bulk establishment of this mark is thought to help drive large-scale remodeling of an initially naive chromatin state during animal embryogenesis...
March 5, 2024: bioRxiv
#36
Xiaogang Feng, Tilde Andersson, Julia Gschwend, Pascal Flüchter, Ivan Berest, Julian L Muff, Daniele Carchidi, Antonie Lechner, Jeshua C de Tenorio, Nina Brander, Ulrich Boehm, Christoph S N Klose, David Artis, Trese Leinders-Zufall, Frank Zufall, Christoph Schneider
The tuft cell-ILC2 circuit orchestrates rapid type 2 responses upon detecting microbe-derived succinate and luminal helminths. Our findings delineate key mechanistic steps, involving IP3R2 engagement and Ca 2+ flux, governing IL-25 production by tuft cells triggered by succinate detection. While IL-17RB plays a pivotal intrinsic role in ILC2 activation, it exerts a regulatory function in tuft cells. Tuft cells exhibit constitutive Il25 expression, placing them in an anticipatory state that facilitates rapid production of IL-25 protein for ILC2 activation...
March 8, 2024: bioRxiv
#37
JOURNAL ARTICLE
K G Zhao, Z Y Li, L F Wang, Z H Di, C Xue, H Zhang, J F Wu, W H Ye, C T Zhou, Y K Ding, W Y Zhang, X T He
This paper presents a numeric study of the dynamic stabilization of the ablative Rayleigh-Taylor instability (ARTI) in the presence of a temporally modulated laser pulse. The results show that the specially modulated laser produces a dynamically stabilized configuration near the ablation front. The physical features of the relevant laser-driven parameters in the unperturbed ablative flows have been analyzed to reveal the inherent stability mechanism underlying the dynamically stabilized configuration. A single-mode ARTI for the modulated laser pulse is first compared with that of the unmodulated laser pulse...
February 2024: Physical Review. E
#38
JOURNAL ARTICLE
Samuel R Wittman, Alejandro Hoberman, Ateev Mehrotra, Lindsay M Sabik, Jonathan G Yabes, Kristin N Ray
IMPORTANCE: Prior research found that pediatric direct-to-consumer (DTC) telemedicine visits are associated with more antibiotic prescribing than in-person primary care visits. It is unclear whether this difference is associated with modality of care (telemedicine vs in-person) or with the context of telemedicine care (primary care vs not primary care). OBJECTIVE: To compare antibiotic management during telemedicine visits with primary care practitioners (PCPs) vs commercial direct-to-consumer (DTC) telemedicine companies for pediatric acute respiratory tract infections (ARTIs)...
March 4, 2024: JAMA Network Open
#39
JOURNAL ARTICLE
Pooja Khajuria, Vishav Deep Sharma, Arti Khajuria, Ram Prakash, R J Choudhary
In this work, we investigate how the structural and optical characteristics of ZrO2 and Na2 ZrO3 are influenced by Sm3+ ion doping. Urea-assisted combustion approach is employed by varying the molar concentration of Sm3+ ions in both the host lattices. XRD pattern revealed the monoclinic crystal system for both samples. XPS investigation has been examined to acquire the chemical information of the samples. FESEM is used to identify the morphology of the samples. The optimum molar concentrations of Sm3+ doped ZrO2 and Na2 ZrO3 phosphors, as per photoluminescence (PL) findings, are 1...
March 13, 2024: Journal of Fluorescence
#40
JOURNAL ARTICLE
Alarming levels of inadequate intake of B group vitamins in tribal lactating women from South India.
Pentapati Siva Santosh Kumar, Arti Gupta, Sai Subhakar Desu, Venkatashiva Reddy B, Yusuf Noorani Shaik, Rakesh Kakkar, Rajeev Aravindakshan
BACKGROUND: Micronutrients are necessary for proper growth and development of the human body, though required in small amounts. Dietary intake of these micronutrients by lactating women is essential for their own health as well as children's overall growth and development. objective of present study is to assess the adequacy of dietary B-group vitamins intake during lactation and to find out the factors associated with their inadequate intake. DESIGN AND METHODS: It was a analysis of data from prospective cohort study for 10 months carried out among 340 Scheduled Tribes mothers in 10 clusters in Guntur district, Andhra Pradesh, India...
January 2024: Journal of Public Health Research
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