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https://www.readbyqxmd.com/read/29332140/identification-of-cross-reactive-antigens-of-c-botulinum-types-a-b-e-f-by-immunoproteomic-approach
#1
Arti Sharma, Sarkaraisamy Ponmariappan, Rani Sarita, Syed Imtiaz Alam, Dev Vrat Kamboj, Sangeeta Shukla
Diseases triggered by microorganisms can be controlled by vaccines, which need neutralizing antigens. Hence, it is very crucial to identify extremely efficient immunogens for immune prevention. Botulism, a fatal neuroparalytic disease, is caused by botulinum neurotoxins produced by the anaerobic, Gram-positive spore-forming bacteria, Clostridium botulinum. Food-borne botulism and iatrogenic botulism are caused by botulinum toxin. Wound botulism, infant botulism, and adult intestinal botulism are caused by primarily C...
January 13, 2018: Current Microbiology
https://www.readbyqxmd.com/read/29332134/breast-cancer-survivorship-state-of-the-science
#2
REVIEW
Kathy Pan, Arti Hurria, Rowan T Chlebowski
PURPOSE: Only recently has breast cancer survivorship earned formal recognition as a research discipline. Complicating survivorship research is the frequent overlap between aging and treatment sequelae. The ACS/ASCO 2016 Breast Cancer Survivorship Care Guideline (Guideline) reflects comprehensive literature review through April 2015, while the jointly sponsored, inaugural Cancer Survivorship Symposium in 2016 (Symposium) reflects ongoing research activity in the area. Together, these platforms provide an opportunity to examine the use of randomized trials and controlled studies in survivorship care research...
January 13, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29320737/genomic-circuitry-underlying-immunological-response-to-pediatric-acute-respiratory-infection
#3
Sarah E Henrickson, Sasikanth Manne, Douglas V Dolfi, Kathleen D Mansfield, Kaela Parkhouse, Rakesh D Mistry, Elizabeth R Alpern, Scott E Hensley, Kathleen E Sullivan, Susan E Coffin, E John Wherry
Acute respiratory tract viral infections (ARTIs) cause significant morbidity and mortality. CD8 T cells are fundamental to host responses, but transcriptional alterations underlying anti-viral mechanisms and links to clinical characteristics remain unclear. CD8 T cell transcriptional circuitry in acutely ill pediatric patients with influenza-like illness was distinct for different viral pathogens. Although changes included expected upregulation of interferon-stimulated genes (ISGs), transcriptional downregulation was prominent upon exposure to innate immune signals in early IFV infection...
January 9, 2018: Cell Reports
https://www.readbyqxmd.com/read/29316366/impact-of-radiation-therapy-on-scleroderma-and-cancer-outcomes-in-scleroderma-patients-with-breast-cancer
#4
Dhaval J Shah, Ram Hirpara, Corrie L Poelman, Adrianne Woods, Laura K Hummers, Fredrick M Wigley, Jean L Wright, Arti Parekh, Virginia D Steen, Robyn T Domsic, Ami A Shah
OBJECTIVES: We examined SSc patients with breast cancer to 1) identify the prevalence of radiation complications and 2) examine SSc outcomes in SSc patients who received radiation therapy (RT) as part of their cancer treatment. METHODS: Patients with SSc and breast cancer were identified from the Johns Hopkins and University of Pittsburgh Scleroderma Center databases. We examined whether erythema, blistering, ulceration, or thickening of the skin developed in the RT port...
January 5, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29311039/sodium-reduced-meat-and-poultry-products-contain-a-significant-amount-of-potassium-from-food-additives
#5
Arti Sharma Parpia, Marc B Goldstein, JoAnne Arcand, France Cho, Mary R L'Abbé, Pauline B Darling
BACKGROUND: Sodium-reduced packaged food products are increasingly available to consumers; however, it is not clear whether they are suitable for inclusion in a potassium-reduced diet. For individuals with impaired renal potassium excretion caused by chronic kidney disease and for those taking certain medications that interfere with the rennin-angiotensin aldosterone axis, the need to limit dietary potassium is important in view of the risk for development of hyperkalemia and fatal cardiac arrhythmias...
January 6, 2018: Journal of the Academy of Nutrition and Dietetics
https://www.readbyqxmd.com/read/29288405/reducing-the-risk-of-postpartum-depression-in-a-low-income-community-through-a-community-health-worker-intervention
#6
Christopher Mundorf, Arti Shankar, Tracy Moran, Sherry Heller, Anna Hassan, Emily Harville, Maureen Lichtveld
Objectives To clarify the effectiveness of perinatal social support interventions in reducing postpartum depression among minority, low-income women. Methods The Transdisciplinary Research Consortium for Gulf Resilience on Women's Health supported a community-based participatory research project to improve perinatal health among low-income, first-time pregnant women living in a vulnerable Gulf Coast region. Community health workers (CHWs) were partnered with recruited women, and used a mix of mobile technology and home visits to develop a supportive relationship during the perinatal period...
December 29, 2017: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/29286978/multiple-scattered-purpuric-vesicles-challenge
#7
Karen Eustace, Janice Harper, Richard Azurdia, Arti Bakshi
No abstract text is available yet for this article.
January 2018: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29284878/role-of-oral-prednisolone-in-the-management-of-postdural-puncture-headache-after-spinal-anesthesia-in-urological-patients
#8
Sunana Gupta, Nandita Mehta, Arti Mahajan, Mohd Reidwan Dar, Neeraj Gupta
Background and Aims: Postdural puncture headache (PDPH) is a frequently encountered complication of spinal anesthesia and may be associated with significant morbidity in some patients. Parenteral corticosteroids have been used in the management of PDPH both prophylactically and after the occurrence of headache. The aim of this study was to evaluate the effect of oral prednisolone in the management of PDPH after spinal anesthesia in urological patients. Materials and Methods: Sixty adult patients who developed PDPH after spinal anesthesia for urological surgeries were randomly allocated to two groups...
October 2017: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/29284331/empathy-mind-set-moderates-the-association-between-low-empathy-and-social-aggression
#9
Arti U Gandhi, Sindes Dawood, Hans S Schroder
Empathy plays an important role in creating and maintaining adaptive interpersonal relationships. Accordingly, existing studies often report a negative correlation between empathy and interpersonal aggression. However, findings are sometimes inconsistent, and concerns have been raised about the size of the overall effect. Here, we examined the potential moderating role of empathy mind-sets-beliefs about the malleability of empathy. We hypothesized that the association between low empathy and aggression would be especially strong if individuals also believed that their levels of empathy were unchangeable (i...
December 1, 2017: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29282150/photoperiodic-responses-of-sahelian-malaria-mosquitoes-anopheles-coluzzii-and-an-arabiensis
#10
Diana L Huestis, Monica L Artis, Peter A Armbruster, Tovi Lehmann
BACKGROUND: Throughout large parts of sub-Saharan Africa, seasonal malaria transmission follows mosquito density, approaching zero during the dry season and peaking during the wet season. The mechanisms by which malaria mosquitoes survive the long dry season, when no larval sites are available remain largely unknown, despite being long recognized as a critical target for vector control. Previous work in the West African Sahel has led to the hypothesis that Anopheles coluzzii (formerly M-form Anopheles gambiae) undergoes aestivation (dry-season diapause), while Anopheles gambiae (s...
December 27, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/29280551/predictors-of-patient-radiation-exposure-during-transcatheter-aortic-valve-replacement
#11
Andrew M Goldsweig, Kevin F Kennedy, Dhaval Kolte, J Dawn Abbott, Paul C Gordon, Barry L Sharaf, Frank W Sellke, Afshin Ehsan, Neel R Sodha, Frank Rutar, Herbert D Aronow
BACKGROUND: Transcatheter aortic valve replacement (TAVR) exposes patients to radiation. OBJECTIVES: We sought to identify factors associated with higher radiation exposure and to quantify their relative influence, which may inform reduction of this hazard. METHODS: All TAVR procedures at Rhode Island Hospital between March 20, 2012 and February 12, 2017 were included. Procedures were performed by two co-primary operators using a Siemens Artis Zeego system...
December 27, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29261309/bioinspired-heterogeneous-ion-pump-membranes-unidirectional-selective-pumping-and-controllable-gating-properties-stemming-from-asymmetric-ionic-group-distribution
#12
Zhen Zhang, Pei Li, Xiang-Yu Kong, Ganhua Xie, Yongchao Qian, Ziqi Wang, Ye Tian, Liping Wen, Lei Jiang
The creation of artificial solid-state ion pump that mimics the delicate ion transport behaviors of biological protein-based ion pump is drawing more and more research attention due to its potential applications in energy conversion, biosensor, and desalination. However, the reported bioinspired double-gated ion pump systems are generally very primary, and can only realize non-selective ion pumping functions with no directionality and uncontrollable ion gating functions, which are far from their biological counterparts...
December 20, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29238072/tissue-transglutaminase-in-the-pathogenesis-of-heart-failure
#13
Arti V Shinde, Nikolaos G Frangogiannis
No abstract text is available yet for this article.
December 13, 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/29237621/patient-characteristics-influence-the-choice-of-biological-drug-in-ra-and-will-make-non-tnfi-biologics-appear-more-harmful-than-tnfi-biologics
#14
Thomas Frisell, Eva Baecklund, Karin Bengtsson, Daniela Di Giuseppe, Helena Forsblad-d'Elia, Johan Askling
OBJECTIVES: With the wide range of biological disease-modifying anti-rheumatic drugs (bDMARDs) available for treating rheumatoid arthritis (RA), and limited evidence to guide the choice for individual patients, we wished to evaluate whether patient characteristics influence the choice of bDMARD in clinical practice, and to quantify the extent to which this would bias direct comparisons of treatment outcome. METHODS: Register-based study of all Swedish patients with RA initiating necrosis factor inhibitor (TNFi), rituximab, abatacept or tocilizumab in 2011-2015 as their first bDMARD (n=6481), or after switch from TNFi as first bDMARD (n=2829)...
December 13, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29235202/three-dimensional-static-articulation-accuracy-of-virtual-models-part-i-system-trueness-and-precision
#15
Sophia Hui Xin Yee, Roxanna Jean Esguerra, Amelia Anya Qin'An Chew, Keng Mun Wong, Keson Beng Choon Tan
PURPOSE: To evaluate the 3D static articulation accuracy of 3 model scanner-CAD systems (Ceramill Map400 [AG], inEos X5 [SIR], Scanner S600 Arti [ZKN]) using a coordinate measuring machine (CMM). Trueness and precision for each system will be reported in Part I. MATERIALS AND METHODS: The master model simulated a single crown opposing a 3-unit fixed dental prosthesis. Five mounted stone cast sets were prepared, and one set was randomly selected. Reference values were obtained by measuring interarch and interocclusal reference features with the CMM...
December 13, 2017: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
https://www.readbyqxmd.com/read/29233548/the-impact-of-actual-body-weight-based-chemotherapy-dosing-and-body-size-on-adverse-events-and-outcome-in-older-patients-with-breast-cancer-results-from-cancer-and-leukemia-group-b-calgb-trial-49907-alliance-a151436
#16
Vicki A Morrison, Linda McCall, Hyman B Muss, Aminah Jatoi, Harvey J Cohen, Constance T Cirrincione, Jennifer A Ligibel, Jacqueline M Lafky, Arti Hurria
OBJECTIVE: Actual weight-based (AWB) chemotherapy dosing is recommended for obese patients in the 2012 ASCO Clinical Practice Guideline. CALGB 49907, which utilized ABW-based adjuvant chemotherapy dosing, was a phase 3 trial in women age≥65years with early stage breast cancer, providing the opportunity to examine impact of such dosing on toxicities and outcome in older patients with breast cancer. MATERIALS AND METHODS: Adverse event data were available for 615 of 633 enrolled patients...
December 7, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29231897/assessment-of-a-salt-reduction-intervention-on-adult-population-salt-intake-in-fiji
#17
Arti Pillay, Kathy Trieu, Joseph Alvin Santos, Arleen Sukhu, Jimaima Schultz, Jillian Wate, Colin Bell, Marj Moodie, Wendy Snowdon, Gary Ma, Kris Rogers, Jacqui Webster
Reducing population salt intake is a global public health priority due to the potential to save lives and reduce the burden on the healthcare system through decreased blood pressure. This implementation science research project set out to measure salt consumption patterns and to assess the impact of a complex, multi-faceted intervention to reduce population salt intake in Fiji between 2012 and 2016. The intervention combined initiatives to engage food businesses to reduce salt in foods and meals with targeted consumer behavior change programs...
December 12, 2017: Nutrients
https://www.readbyqxmd.com/read/29229611/opposing-actions-of-fibroblast-and-cardiomyocyte-smad3-signaling-in-the-infarcted-myocardium
#18
Ping Kong, Arti V Shinde, Ya Su, Ilaria Russo, Bijun Chen, Amit Saxena, Simon J Conway, Jonathan M Graff, Nikolaos G Frangogiannis
Background -Transforming Growth Factor (TGF)-βs regulate a wide range of cellular responses by activating Smad-dependent and Smad-independent cascades. In the infarcted heart, Smad3 signaling is activated in both cardiomyocytes and interstitial cells. We hypothesized that cell-specific actions of Smad3 regulate repair and remodeling in the infarcted myocardium. Methods -In order to dissect cell-specific Smad3 actions in myocardial infarction, we generated mice with Smad3 loss in activated fibroblasts, or in cardiomyocytes...
December 11, 2017: Circulation
https://www.readbyqxmd.com/read/29222227/pings-phone-based-intervention-under-nurse-guidance-after-stroke-interim-results-of-a-pilot-randomized-controlled-trial
#19
Fred Sarfo, Frank Treiber, Mulugeta Gebregziabher, Sheila Adamu, Sachin Patel, Michelle Nichols, Dominic Awuah, Asumadu Sakyi, Nyantakyi Adu-Darko, Arti Singh, Raelle Tagge, Jenkins Carolyn, Bruce Ovbiagele
BACKGROUND AND PURPOSE: Stroke exacts an immense toll in sub-Saharan Africa where there are few resources, and stroke prevention research is limited. The aim of this study is to test the feasibility and preliminary efficacy of an m-Health technology-enabled, nurse-guided intervention in improving blood pressure (BP) control among Ghanaian stroke patients within 1 month of symptom onset. METHODS: We conducted a 2-arm cluster pilot randomized controlled trial involving 60 recent stroke survivors encountered within a single tertiary medical system in Ghana...
December 8, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29212863/modelling-the-implications-of-reducing-smoking-prevalence-the-benefits-of-increasing-the-uk-tobacco-duty-escalator-to-public-health-and-economic-outcomes
#20
Andre Knuchel-Takano, Daniel Hunt, Abbygail Jaccard, Arti Bhimjiyani, Martin Brown, Lise Retat, Katrina Brown, Sebastian Hinde, Chit Selvarajah, Linda Bauld, Laura Webber
INTRODUCTION: Taxing tobacco is one of the most effective ways to reduce smoking prevalence, mitigate its devastating consequential health harms and progress towards a tobacco-free society. This study modelled the health and economic impacts of increasing the existing cigarette tobacco duty escalator (TDE) in the UK from the current 2% above consumer price inflation to 5%. METHODS: A two-stage modelling process was used. First, a non-linear multivariate regression model was fitted to cross-sectional smoking data, creating longitudinal projections from 2015 to 2035...
December 6, 2017: Tobacco Control
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