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https://www.readbyqxmd.com/read/28087452/congenital-anonychia-and-uncombable-hair-syndrome-co-inheritance-of-homozygous-mutations-in-rspo4-and-padi3
#1
Chao-Kai Hsu, Maria Teresa Romano, Arti Nanda, Ellie Rashidghamat, John Y W Lee, Hsin-Yu Huang, Chankiat Songsantiphap, Julia Yu-Yun Lee, Hejab Al-Ajmi, Regina C Betz, Michael A Simpson, John A McGrath, Christos Tziotzios
No abstract text is available yet for this article.
January 10, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28073815/costs-of-care-for-hospitalized-children-associated-with-preferred-language-and-insurance-type
#2
K Casey Lion, Davene R Wright, Arti D Desai, Rita Mangione-Smith
OBJECTIVE: The study goal was to determine whether preferred language for care and insurance type are associated with cost among hospitalized children. METHODS: A retrospective cohort study was conducted of inpatients at a freestanding children's hospital from January 2011 to December 2012. Patient information and hospital costs were obtained from administrative data. Cost differences according to language and insurance were calculated using multivariate generalized linear model estimates, allowing for language/insurance interaction effects...
January 10, 2017: Hospital Pediatrics
https://www.readbyqxmd.com/read/28073801/predictors-of-work-disability-after-start-of-anti-tnf-therapy-in-a-national-cohort-of-swedish-patients-with-rheumatoid-arthritis-does-early-anti-tnf-therapy-bring-patients-back-to-work
#3
T Olofsson, I F Petersson, J K Eriksson, M Englund, J A Nilsson, P Geborek, L T H Jacobsson, J Askling, M Neovius
OBJECTIVES: To examine predictors of work ability gain and loss after anti-tumour necrosis factor (TNF) start, respectively, in working-age patients with rheumatoid arthritis (RA) with a special focus on disease duration. METHODS: Patients with RA, aged 19-62 years, starting their first TNF inhibitor 2006-2009 with full work ability (0 sick leave/disability pension days during 3 months before bio-start; n=1048) or no work ability (90 days; n=753) were identified in the Swedish biologics register (Anti-Rheumatic Treatment In Sweden, ARTIS) and sick leave/disability pension days retrieved from the Social Insurance Agency...
January 10, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28062326/the-impact-of-comorbidity-on-surgical-outcomes-in-older-adults-with-cancer
#4
REVIEW
Virginia Sun, Peggy S Burhenn, Lily Lai, Arti Hurria
OBJECTIVES: To provide an overview of the impact of comorbidity on surgical outcomes and postoperative geriatric events in older adults with cancer, and review key components of quality perioperative nursing care of older adults with cancer. DATA SOURCES: Journal articles, research reports, state of the science papers, position papers, and clinical guidelines from professional organizations. CONCLUSION: The high prevalence of multiple comorbidities and the associated burden of geriatric events in older adults after cancer surgery have a substantial impact on surgical outcomes, quality of life, and health care costs...
January 3, 2017: Seminars in Oncology Nursing
https://www.readbyqxmd.com/read/28061004/objective-physical-and-mental-markers-of-self-reported-fatigue-in-women-undergoing-neo-adjuvant-chemotherapy-for-early-stage-breast-cancer
#5
Joanne E Mortimer, Sarah Waliany, Christina M Dieli-Conwright, Sunita K Patel, Arti Hurria, Joseph Chao, Brian Tiep, Carolyn E Behrendt
BACKGROUND: Objective, treatment-independent markers of cancer-related fatigue are needed to advance clinical trials. In the current study, the authors evaluated physical, neurocognitive, and serologic markers for correlation with self-reported fatigue before and after (neo)adjuvant chemotherapy for patients with early-stage breast cancer. METHODS: Women with AJCC TNM Stage I-III breast cancer consented to assessment before and after the completion of 4 cycles of dose-dense doxorubicin and cyclophosphamide...
January 6, 2017: Cancer
https://www.readbyqxmd.com/read/28060519/development-of-a-chiral-dmap-catalyst-for-the-dynamic-kinetic-resolution-of-azole-hemiaminals
#6
Artis Kinens, Marcis Sejejs, Adam S Kamlet, David W Piotrowski, Edwin Vedejs, Edgars Suna
A new catalyst for the dynamic kinetic resolution of azole hemiaminals has been developed using late-stage structural modifications of the tert-leucinol-derived chiral subunit of DMAP species.
January 11, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28056339/asbestos-induced-mesothelial-to-fibroblastic-transition-is-modulated-by-the-inflammasome
#7
Joyce K Thompson, Maximilian B MacPherson, Stacie L Beuschel, Arti Shukla
Despite the causal relationship established between malignant mesothelioma (MM) and asbestos exposure, the exact mechanism by which asbestos induces this neoplasm and other asbestos-related diseases is still not well understood. MM is characterized by chronic inflammation, which is believed to play an intrinsic role in the origin of this disease. We recently found that asbestos activates the nod-like receptor family member containing a pyrin domain 3 (NLRP3) inflammasome in a protracted manner, leading to an up-regulation of IL-1β and IL-18 production in human mesothelial cells...
January 2, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/28048767/su-f-i-77-radiation-dose-in-cardiac-catheterization-procedures-impact-of-a-systematic-reduction-in-pulsed-fluoroscopy-frame-rate
#8
C Schultz, S Dixon
PURPOSE: To evaluate whether one small systematic reduction in fluoroscopy frame rate has a significant effect on the total air kerma and/or dose area product for diagnostic and interventional cardiac catheterization procedures. METHODS: The default fluoroscopy frame rate (FFR) was lowered from 15 to 10 fps in 5 Siemens™ Axiom Artis cardiac catheterization labs (CCL) on July 1, 2013. A total of 7212 consecutive diagnostic and interventional CCL procedures were divided into two study groups: 3602 procedures from 10/1/12 -6/30/13 with FFR of 15 fps; and 3610 procedures 7/1/13 - 3/31/14 at 10 fps...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048353/su-d-209-02-percent-depth-dose-curves-for-fluoroscopic-x-ray-beam-qualities-incorporating-copper-filtration
#9
K Wunderle, A Godley, Z Shen, J Rakowski, F Dong
PURPOSE: The purpose of this investigation was to quantify percent depth dose (PDD) curves for fluoroscopic x-ray beam qualities incorporating added copper filtration. METHODS: A PTW (Freiburg, Germany) MP3 water tank was used with a Standard Imaging (Middleton, WI) Exradin Model 11 Spokas Chamber to measure PDD curves for 60, 80, 100 and 120 kVp x-ray beams with copper filtration ranging from 0.0-0.9 mm at 22cm and 42cm fields of view from 0 to 150 mm of water...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047451/su-f-i-05-dose-symmetry-for-ctdi-equivalent-measurements-with-limited-angle-cbct
#10
V Singh, S McKenney, P Sunde, W Feng, D Bakalyar
PURPOSE: CTDI measurements, useful for characterizing the x-ray output for multi-detector CT (MDCT), require a 360° rotation of the gantry; this presents a problem for cone beam CT (CBCT) due to its limited angular rotation. The purpose of this work is to demonstrate a methodology for overcoming this limited angular rotation so that CTDI measurements can also be made on CBCT systems making it possible to compare the radiation output from both types of system with a common metric. METHODS: The symmetry of the CTDI phantom allows a 360° CTDI measurement to be replaced with two 180° measurements...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047376/su-f-i-75-half-value-layer-thicknesses-and-homogeneity-coefficients-for-fluoroscopic-x-ray-beam-spectra-incorporating-spectral-filtration
#11
K Wunderle, A Godley, Z Shen, J Rakowski, F Dong
PURPOSE: The purpose of this investigation is to quantify various first half-value-layers (HVLs), second HVLs and homogeneity coefficients (HCs) for a state-of-the-art fluoroscope utilizing spectral (copper) filtration. METHODS: A Radcal (Monrovia, Ca) AccuPro dosimeter with a 10×6-6 calibrated ionization chamber was used to measure air kerma for radiographic x-ray exposures made on a Siemens (Erlangen, Germany) Artis ZeeGo fluoroscope operated in the service mode...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046710/su-f-i-76-fluoroscopic-x-ray-beam-profiles-for-spectra-incorporating-copper-filtration
#12
K Wunderle, A Godley, Z Shen, J Rakowski, F Dong
PURPOSE: The purpose of this investigation is to characterize and quantify X-ray beam profiles for fluoroscopic x-ray beam spectra incorporating spectral (copper) filtration. METHODS: A PTW (Freiburg, Germany) type 60016 silicon diode detector and PTW MP3 water tank were used to measure X-ray beam profiles for 60, 80, 100 and 120 kVp x-ray beams at five different copper filtration thicknesses ranging from 0-0.9 mm at 22 and 42 cm fields of view and depths of 1, 5, and 10 cm in both the anode-cathode axis (inplane) and cross-plane directions...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046649/su-f-i-72-evaluation-of-the-ancillary-lead-shielding-for-optimizing-radiation-protection-in-the-interventional-radiology-department
#13
E Tonkopi, C Lightfoot, E LeBlanc
PURPOSE: The rising complexity of interventional fluoroscopic procedures has resulted in an increase of occupational radiation exposures in the interventional radiology (IR) department. This study assessed the impact of ancillary shielding on optimizing radiation protection for the IR staff. METHODS: Scattered radiation measurements were performed in two IR suites equipped with Axiom Artis systems (Siemens Healthcare, Erlangen, Germany) installed in 2006 and 2010...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28013367/actin-polymerization-plays-a-significant-role-in-asbestos-induced-inflammasome-activation-in-mesothelial-cells-in-vitro
#14
Maximilian MacPherson, Catherine Westbom, Helen Kogan, Arti Shukla
Asbestos exposure leads to malignant mesothelioma (MM), a deadly neoplasm of mesothelial cells of various locations. Although there is no doubt about the role of asbestos in MM tumorigenesis, mechanisms are still not well explored. Recently, our group demonstrated that asbestos causes inflammasome priming and activation in mesothelial cells, which in part is dependent on oxidative stress. Our current study sheds light on yet another mechanism of inflammasome activation by asbestos. Here we show the role of actin polymerization in asbestos-induced activation of the nod-like receptor pyrin domain-containing protein 3 (NLRP3) inflammasome...
December 24, 2016: Histochemistry and Cell Biology
https://www.readbyqxmd.com/read/28010770/a-single-and-two-step-isomerization-process-for-d-tagatose-and-l-ribose-bioproduction-using-l-arabinose-isomerase-and-d-lyxose-isomerase
#15
Manisha J Patel, Rekha C Akhani, Arti T Patel, Samir R Dedania, Darshan H Patel
l-ribose and d-tagatose are biochemically synthesized using sugar isomerases. The l-arabinose isomerase gene from Shigella flexneri (Sf-AI) was cloned and expressed in Escherichia coli BL-21. Sf-AI was applied for the bioproduction of d-tagatose from d-galactose. l-ribose synthesis was performed by two step isomerization using Sf-AI and d-lyxose/ribose isomerase from Cohnella laevoribosii. The overall 22.3% and 25% conversion rate were observed for d-tagatose and l-ribose production from d-galactose and l-arabinose respectively...
February 2017: Enzyme and Microbial Technology
https://www.readbyqxmd.com/read/28004127/-surgical-access-routes-to-the-hip-joint-in-the-elderly
#16
M Nogler, M Thaler
There are a large number of different approaches to the hip joint. Several conventional and minimally invasive portals exist and numerous technical variations with different instrument sets are available. All approaches can be regarded as standard and can be utilized lege artis. The main differences between approaches are their potential to preserve muscles and avoid damage which would slow down rehabilitation and mobilization. In the elderly the preservation of abductor function is, in the authors' opinion, of utmost importance...
December 21, 2016: Der Orthopäde
https://www.readbyqxmd.com/read/28003151/urogenital-schistosomiasis-during-pregnancy-is-associated-with-low-birth-weight-delivery-analysis-of-a-prospective-cohort-of-pregnant-women-and-their-offspring-in-gabon
#17
Ghyslain Mombo-Ngoma, Josiane Honkpehedji, Arti Basra, Jean Rodolphe Mackanga, Rella Manego Zoleko, Jeannot Zinsou, Jean Claude Dejon Agobe, Bertrand Lell, Pierre-Blaise Matsiegui, Raquel Gonzales, Selidji Todagbe Agnandji, Maria Yazdanbakhsh, Clara Menendez, Peter G Kremsner, Ayola Akim Adegnika, Michael Ramharter
An estimated 40 million women of childbearing age suffer from schistosomiasis. Animal models indicate a deleterious effect of maternal schistosomiasis on pregnancy outcomes. To date there is a lack of epidemiological evidence evaluating schistosomiasis-related morbidity in pregnancy. This study was designed to describe the impact of urogenital schistosomiasis on pregnancy outcomes in a highly endemic region of central Africa. Pregnant women attending antenatal clinics in Fougamou and Lambaréné, Gabon, were consecutively screened for the presence of Schistosoma haematobium eggs in diurnal urine samples...
December 18, 2016: International Journal for Parasitology
https://www.readbyqxmd.com/read/28002727/allergen-exposure-when-timing-is-everything
#18
Tanel Mahlakõiv, David Artis
It is known that young children exposed to allergens are prone to develop asthma later in life. In this issue of Immunity, de Kleer et al. (2016) identify IL-33 as a key player in the developing lung for sensitization to environmental allergens and airway hyperreactivity.
December 20, 2016: Immunity
https://www.readbyqxmd.com/read/27996364/subcutaneous-lidocaine-infusion-for-pain-in-patients-with-cancer
#19
Davinia S E Seah, Alan Herschtal, Ha Tran, Arti Thakerar, Sonia Fullerton
BACKGROUND: Intravenous lidocaine is effective in treating pain. Limited studies have assessed the effectiveness and safety of subcutaneous lidocaine infusions. METHODS: We conducted a retrospective review of patients with cancer who received subcutaneous lidocaine infusions for pain. Patient characteristics, pain scores and opioid doses before and after lidocaine, and details of infusions were recorded. We identified three time periods of interest. T0 is defined as the 24-hour period immediately before commencing lidocaine treatment...
December 20, 2016: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/27995840/storm-impact-and-depression-among-older-adults-living-in-hurricane-sandy-affected-areas
#20
Jo Anne Sirey, Jacquelin Berman, Ashley Halkett, Nancy Giunta, Janice Kerrigan, Elmira Raeifar, Amanda Artis, Samprit Banerjee, Patrick J Raue
OBJECTIVE: Research on the impact of natural disasters on the mental health of older adults finds both vulnerabilities and resilience. We report on the rates of clinically significant depression among older adults (aged ≥60 years) living in areas affected by Hurricane Sandy in 2012 and the factors associated with mental health need. METHODS: The Sandy Mobilization, Assessment, Referral and Treatment for Mental Health (SMART-MH) program integrates community outreach and needs assessments to identify older adults with mental health and aging service needs...
December 20, 2016: Disaster Medicine and Public Health Preparedness
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