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https://www.readbyqxmd.com/read/28228596/antimicrobials-from-human-skin-commensal-bacteria-protect-against-staphylococcus-aureus-and-are-deficient-in-atopic-dermatitis
#1
Teruaki Nakatsuji, Tiffany H Chen, Saisindhu Narala, Kimberly A Chun, Aimee M Two, Tong Yun, Faiza Shafiq, Paul F Kotol, Amina Bouslimani, Alexey V Melnik, Haythem Latif, Ji-Nu Kim, Alexandre Lockhart, Keli Artis, Gloria David, Patricia Taylor, Joanne Streib, Pieter C Dorrestein, Alex Grier, Steven R Gill, Karsten Zengler, Tissa R Hata, Donald Y M Leung, Richard L Gallo
The microbiome can promote or disrupt human health by influencing both adaptive and innate immune functions. We tested whether bacteria that normally reside on human skin participate in host defense by killing Staphylococcus aureus, a pathogen commonly found in patients with atopic dermatitis (AD) and an important factor that exacerbates this disease. High-throughput screening for antimicrobial activity against S. aureus was performed on isolates of coagulase-negative Staphylococcus (CoNS) collected from the skin of healthy and AD subjects...
February 22, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28221212/an-unusual-blistering-disorder-answer
#2
Prativa Jayasekera, Arti Bakshi, Hazel K Bell
No abstract text is available yet for this article.
March 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28221209/an-unusual-blistering-disorder-challenge
#3
Prativa Jayasekera, Arti Bakshi, Hazel K Bell
No abstract text is available yet for this article.
March 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28219113/personality-coping-and-social-support-as-predictors-of-long-term-quality-of-life-trajectories-in-older-breast-cancer-survivors-calgb-protocol-369901-alliance
#4
Estrella Durá-Ferrandis, Jeanne S Mandelblatt, Jonathan Clapp, George Luta, Leigh Anne Faul, Gretchen Kimmick, Harvey J Cohen, Rachel L Yung, Arti Hurria
OBJECTIVE: To determine long-term quality-of-life (QoL) trajectories among breast cancer survivors aged 65+ ("older") evaluating the effects of personality and social support. METHODS: Older women (N = 1280) newly diagnosed with invasive, non-metastatic breast cancer completed baseline assessments. Follow-up data were collected 6 and 12 months later and then annually for up to 7 years (median 4.5 years). QoL was assessed using EORTC-QLQC30 emotional, physical, and cognitive scales...
February 20, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/28212439/correction-type-i-interferon-receptor-deficiency-in-dendritic-cells-facilitates-systemic-murine-norovirus-persistence-despite-enhanced-adaptive-immunity
#5
Timothy J Nice, Lisa C Osborne, Vesselin T Tomov, David Artis, E John Wherry, Herbert W Virgin
[This corrects the article DOI: 10.1371/journal.ppat.1005684.].
February 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28208860/chronic-osteomyelitis-of-skull-due-to-pseudomonasaeruginosa-a-delayed-uncommon-complication-following-craniotomy
#6
Swati Khullar, Poodipedi Sarat Chandra, Ramesh Sharannappa Doddamani, Arti Kapil, Benu Dhawan
No abstract text is available yet for this article.
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28188485/feasibility-of-laser-guided-percutaneous-pedicle-screw-placement-in-the-lumbar-spine-using-a-hybrid-or
#7
P H Richter, F Gebhard, M Salameh, K Schuetze, M Kraus
PURPOSE: Innovations in intraoperative imaging lead to major changes in orthopaedic surgery. In our setting, a 3D flat-panel c-arm (Artis zeego) is mounted on a robotic arm offering an integrated aiming tool (Syngo iGuide). Our aim was to investigate the feasibility of Syngo iGuide for pedicle screw placement in comparison with fluoroscopic screw implantation. METHODS: In 10 lumbar models, 100 screws were implanted. In 5 models, a standard fluoroscopic technique was used...
February 10, 2017: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/28183732/association-of-bronchiolitis-clinical-pathway-adherence-with-length-of-stay-and-costs
#8
Mersine A Bryan, Arti D Desai, Lauren Wilson, Davene R Wright, Rita Mangione-Smith
OBJECTIVES: To examine the associations between the level of adherence to bronchiolitis clinical pathway recommendations, health care use, and costs. METHODS: We conducted a retrospective cohort study of 267 patients ≤24 months old diagnosed with bronchiolitis from 12/2009 to 7/2012. Clinical pathway adherence was assessed by using a standardized scoring system (0-100) for 18 quality measures obtained by medical record review. Level of adherence was categorized into low, middle, and high tertiles...
February 9, 2017: Pediatrics
https://www.readbyqxmd.com/read/28169362/allometric-scaling-in-vitro
#9
Arti Ahluwalia
About two decades ago, West and coworkers established a model which predicts that metabolic rate follows a three quarter power relationship with the mass of an organism, based on the premise that tissues are supplied nutrients through a fractal distribution network. Quarter power scaling is widely considered a universal law of biology and it is generally accepted that were in-vitro cultures to obey allometric metabolic scaling, they would have more predictive potential and could, for instance, provide a viable substitute for animals in research...
February 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28157540/large-intragenic-deletion-in-dstyk-underlies-autosomal-recessive-complicated-spastic-paraparesis-spg23
#10
John Y W Lee, Chao-Kai Hsu, Magdalene Michael, Arti Nanda, Lu Liu, James R McMillan, Celine Pourreyron, Takuya Takeichi, Jakub Tolar, Evan Reid, Thomas Hayday, Sergiu C Blumen, Saif Abu-Mouch, Rachel Straussberg, Lina Basel-Vanagaite, Yael Barhum, Yasmin Zouabi, Hejab Al-Ajmi, Hsin-Yu Huang, Ting-Chien Lin, Masashi Akiyama, Julia Y Y Lee, W H Irwin McLean, Michael A Simpson, Maddy Parsons, John A McGrath
SPG23 is an autosomal-recessive neurodegenerative subtype of lower limb spastic paraparesis with additional diffuse skin and hair dyspigmentation at birth followed by further patchy pigment loss during childhood. Previously, genome-wide linkage in an Arab-Israeli pedigree mapped the gene to an approximately 25 cM locus on chromosome 1q24-q32. By using whole-exome sequencing in a further Palestinian-Jordanian SPG23 pedigree, we identified a complex homozygous 4-kb deletion/20-bp insertion in DSTYK (dual serine-threonine and tyrosine protein kinase) in all four affected family members...
February 2, 2017: American Journal of Human Genetics
https://www.readbyqxmd.com/read/28156602/integration-of-palliative-care-for-patients-with-solid-tumors-on-phase-i-clinical-trials
#11
Vincent M Chung, Marianna Koczywas, Anna Cathy Williams, Arti Hurria, Tami R Borneman, Rhonda Cooper, Louise Knight, Patricia Fischer, Denise Gallagher, Thomas J Smith
: 138 Background: Cancer patients receiving Phase I clinical trials are a population with advanced disease, high symptom burden, and with multiple QOL concerns including use of advance directives. METHODS: An NCI funded R01 is currently in progress (2014-2019) as a randomized clinical trial to test a palliative care intervention (PCI) in this population. The PCI includes comprehensive patient assessment, goals of care communication, interdisciplinary care planning and patient teaching...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28152603/large-scale-and-targeted-quantitative-cross-linking-ms-using-isotope-labeled-protein-interaction-reporter-pir-cross-linkers
#12
Xuefei Zhong, Arti T Navare, Juan D Chavez, Jimmy K Eng, Devin K Schweppe, James E Bruce
Quantitative measurement of chemically cross-linked proteins is crucial to reveal dynamic information about protein structures and protein-protein interactions and how these are differentially regulated during stress, aging, drug treatment, and most perturbations. Previously, we demonstrated how quantitative in vivo cross-linking (CL) with stable isotope labeling of amino acids in cell culture (SILAC) enables both heritable and dynamic changes in cells to be visualized. In this work, we demonstrate the technical feasibility of proteome-scale quantitative in vivo CL-MS using isotope-labeled protein interaction reporter (PIR) cross-linkers and E...
February 3, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28134476/protective-effects-of-breastfeeding-against-acute-respiratory-tract-infections-and-diarrhoea-findings-of-a-cohort-study
#13
Raheema Abdul Raheem, Colin W Binns, Hui J Chih
AIM: The objective of this paper is to identify associations between breastfeeding and acute respiratory tract infections (ARTIs) and diarrhoea. METHODS: A cohort of 458 mothers was recruited at the antenatal clinics at Indira Gandhi Memorial and Abdul Rahman Dhon Kaleyfaanu Hospitals. Mothers were interviewed 'face-to-face' at 36 weeks of gestation and at 1, 3 and 6 months after delivery. The questionnaires included demographic information about parents, infant feeding methods and breastfeeding duration...
January 30, 2017: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/28128353/genotyping-of-human-rhinovirus-in-adult-patients-with-acute-respiratory-infections-identified-predominant-infections-of-genotype-a21
#14
Lili Ren, Donghong Yang, Xianwen Ren, Mingkun Li, Xinlin Mu, Qi Wang, Jie Cao, Ke Hu, Chunliang Yan, Hongwei Fan, Xiangxin Li, Yusheng Chen, Ruiqin Wang, Fucheng An, Shuchang An, Ming Luo, Ying Wang, Yan Xiao, Zichun Xiang, Yan Xiao, Li Li, Fang Huang, Qi Jin, Zhancheng Gao, Jianwei Wang
Human rhinovirus (HRV) is an important causative agent of acute respiratory tract infections (ARTIs). The roles of specific HRV genotypes in patients suffering from ARTIs have not been well established. We recruited 147 adult inpatients with community-acquired pneumonia (CAP) and 291 adult outpatients with upper ARTIs (URTIs). Respiratory pathogens were screened via PCR assays. HRV was detected in 42 patients, with 35 species A, five B and two C. Seventeen genotypes were identified, and HRV-A21 ranked the highest (9/42, 21...
January 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28126203/skin-derived-tslp-systemically-expands-regulatory-t-cells
#15
Theresa M Leichner, Atsushi Satake, Victor Sanoe Harrison, Yukinori Tanaka, Angela S Archambault, Brian S Kim, Mark C Siracusa, Warren J Leonard, Ali Naji, Gregory F Wu, David Artis, Taku Kambayashi
Regulatory T cells (Tregs) are a subset of CD4(+) T cells with suppressive function and are critical for limiting inappropriate activation of T cells. Hence, the expansion of Tregs is an attractive strategy for the treatment of autoimmune diseases. Here, we demonstrate that the skin possesses the remarkable capacity to systemically expand Treg numbers by producing thymic stromal lymphopoietin (TSLP) in response to vitamin D receptor stimulation. An ∼2-fold increase in the proportion and absolute number of Tregs was observed in mice treated topically but not systemically with the Vitamin D3 analog MC903...
January 23, 2017: Journal of Autoimmunity
https://www.readbyqxmd.com/read/28122829/qualitative-study-of-primary-care-clinicians-views-on-point-of-care-testing-for-c-reactive-protein-for-acute-respiratory-tract-infections-in-family-medicine
#16
Victoria Hardy, Matthew Thompson, Gina A Keppel, William Alto, M Ashworth Dirac, Jon Neher, Christopher Sanford, Jaime Hornecker, Allison Cole
OBJECTIVE: To explore clinicians views of the barriers and facilitators to use of C-reactive protein (CRP) point-of-care tests (POCT) in US family medicine clinics for the management of acute respiratory tract infections (ARTIs) in adults. SETTING: Five family medicine clinics across two US states. PARTICIPANTS: 30 clinicians including 18 physicians, 9 physician residents, 2 physician assistants and 1 nurse practitioner, took part in the study...
January 25, 2017: BMJ Open
https://www.readbyqxmd.com/read/28119952/data-supporting-the-effects-of-lysozyme-on-mrna-and-protein-expression-in-a-colonic-epithelial-scratch-wound-model
#17
Sarah K Abey, Yuana Yuana, Paule V Joseph, Natnael D Kenea, Nicolaas H Fourie, LeeAnne B Sherwin, Gregory E Gonye, Paul A Smyser, Erin S Stempinski, Christina M Boulineaux, Kristen R Weaver, Christopher K E Bleck, Wendy A Henderson
Colonic epithelial health is implicated in a host of gastrointestinal (GI) diseases and disorders. Lysozyme is suspected to play a role in the ability of the epithelium to recover from injury (Abey et al., in press; Gallo, 2012; Rubio, 2014) [1], [2], [3]. Disrupted repair mechanisms may lead to delayed or ineffective recovery and disruptions to epithelial biology resulting in GI symptoms and altered barrier function (Peterson and Artis, 2014) [4]. The effect of lysozyme on the transcriptomic and proteomic profile of healthy colonic epithelial cells was investigated...
April 2017: Data in Brief
https://www.readbyqxmd.com/read/28117891/age-hepatitis-c-virus-infection-and-the-risk-of-cancer-unlocking-a-complex-puzzle-of-interactions
#18
Daneng Li, Arti Hurria
No abstract text is available yet for this article.
January 24, 2017: Cancer
https://www.readbyqxmd.com/read/28107179/nuclear-prmt5-cyclin-d1-and-il-6-are-associated-with-poor-outcome-in-oropharyngeal-squamous-cell-carcinoma-patients-and-is-inversely-associated-with-p16-status
#19
Bhavna Kumar, Arti Yadav, Nicole V Brown, Songzhu Zhao, Michael J Cipolla, Paul E Wakely, Alessandra C Schmitt, Robert A Baiocchi, Theodoros N Teknos, Matthew Old, Pawan Kumar
Protein arginine methyltransferase-5 (PRMT5) plays an important role in cancer progression by repressing the expression of key tumor suppressor genes via the methylation of transcriptional factors and chromatin-associated proteins. However, very little is known about the expression and biological role of PRMT5 in head and neck cancer. In this study, we examined expression profile of PRMT5 at subcellular levels in oropharyngeal squamous cell carcinoma (OPSCC) and assessed its correlation with disease progression and patient outcome...
January 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/28102176/synthesis-of-magnetic-cytosine-imprinted-chitosan-nanoparticles
#20
Mei-Hwa Lee, Arti Ahluwalia, Jian-Zhou Chen, Neng-Lang Shih, Hung-Yin Lin
Molecularly imprinted polymer nanoparticles incorporating magnetic nanoparticles (MNPs) have been investigated for their selective adsorption properties. Here we describe the synthesis and characterization of magnetic cytosine-imprinted chitosan nanoparticles (CIPs) for gene delivery. In particular, CIPs carrying the mammalian expression plasmid of enhanced green fluorescent protein were prepared by the co-precipitation of MNPs, chitosan and a template nucleobase (cytosine). The results show that the selective reabsorption of cytosine to magnetic CIPs was at least double that of non-imprinted polymers and other nucleobases (such as adenine and thymine)...
January 19, 2017: Nanotechnology
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