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Christopher D Herren, Alexandra Peister, Timothy S Breton, Maggie S Hill, Marcy S Anderson, Adeline W Chang, Sydney B Klein, Mackenzie M Thornton, Stacy J Vars, Kasey E Wagner, Paige L Wiebe, Thomas G Williams, Coraima P Yanez, Jasanta M Ackles, Darius Artis, Ryan J Brazier, Ronald J Bryant, Kerel O Callwood, Isaiah H Carter, Cameron L DeBose, Christian D Edwards, Isaiah C Ezemba, Renshal R Joaquin, Zakai M Meghoo-Peddie, Ziha G Meghoo-Peddie, Ryan W Moore, Christopher E Smith, Adam J Turner, Raymond L Vorters, Jeffrey J Wider, Liesel L Krout, Mia S Comis, Madison J Davick, Eli E Michaud, Bailey E Shevenell, Sarah E Stanley, Chelsey I Frank, Jacob R Montgomery, Lawrence S Blumer, Jean A Doty, Martha Smith-Caldas, Welkin H Pope, Steven G Cresawn, Daniel A Russell, Rebecca A Garlena, Deborah Jacobs-Sera, Graham F Hatfull
Four subcluster L2 mycobacteriophages, Finemlucis, Miley16, Wilder, and Zakai, that infect Mycobacterium smegmatis mc(2)155 were isolated. The four phages are closely related to each other and code for 12 to 14 tRNAs and 130 to 132 putative protein-coding genes, including tyrosine integrases, cro, immunity repressors, and excise genes involved in the establishment of lysogeny.
November 16, 2017: Genome Announcements
Arti K Rai, Robert Cook-Deegan
No abstract text is available yet for this article.
November 17, 2017: Science
Arti Sharma Parpia, Mary L'Abbé, Marc Goldstein, Joanne Arcand, Bernadene Magnuson, Pauline Darling
OBJECTIVE: Patients with chronic kidney disease (CKD) are advised to limit their dietary intake of phosphorus and potassium as hyperphosphatemia and hyperkalemia are both associated with an increased risk of mortality. There is uncertainty concerning the actual content of these minerals in the Canadian food supply, as phosphorus and potassium are increasingly being used as food additives. This study aimed to determine the impact of food additives on the chemically analyzed content of phosphorus, potassium, sodium, and protein in commonly consumed meat, poultry, and fish products (MPFs)...
November 14, 2017: Journal of Renal Nutrition
Antonia Wallrapp, Samantha J Riesenfeld, Patrick R Burkett, Raja-Elie E Abdulnour, Jackson Nyman, Danielle Dionne, Matan Hofree, Michael S Cuoco, Christopher Rodman, Daneyal Farouq, Brian J Haas, Timothy L Tickle, John J Trombetta, Pankaj Baral, Christoph S N Klose, Tanel Mahlakõiv, David Artis, Orit Rozenblatt-Rosen, Isaac M Chiu, Bruce D Levy, Monika S Kowalczyk, Aviv Regev, Vijay K Kuchroo
This corrects the article DOI: 10.1038/nature24029.
November 15, 2017: Nature
Arti Negi, Mridu Anand, Avinash Singh, Awadhesh Kumar, Chinmoy Sahu, Kashi Nath Prasad
Objective: Pseudomonas aeruginosa is one of the leading pathogen causing healthcare-associated infections, particularly in immunocompromised and critically ill patients. The development of carbapenem resistance in P. aeruginosa infections is worrisome. Data specifically comparing the susceptibility of the three available carbapenems are lacking in the Indian subcontinent. Materials and Methods: We evaluated the minimum inhibitory concentrations (MICs) of the three commonly used carbapenems- imipenem, meropenem, and doripenem against, 435 P...
October 2017: Indian Journal of Critical Care Medicine
Wolfgang Kamin, Petra Funk, Georg Seifert, Andrea Zimmermann, Walter Lehmacher
Objective - Pelargonium sidoides preparation EPs 7630 has been proven safe and effective in acute respiratory tract infections (aRTIs), but data for young children have not been presented separately. We reviewed clinical studies and present an overview of known and newly analyzed data from children <6 years. Methods - We searched MEDLINE and EMBASE for interventional and non-interventional studies which investigated the effects of EPs 7630 in aRTIs and included children <6 years of age. Subgroup analyses for this age range were performed for symptom scales, global efficacy or effectiveness assessments, and safety outcomes...
November 9, 2017: Current Medical Research and Opinion
George S Alexopoulos, Jo Anne Sirey, Samprit Banerjee, Danielle S Jackson, Dimitris N Kiosses, Cristina Pollari, Richard S Novitch, Amanda Artis, Patrick J Raue
OBJECTIVE: The Personalized Intervention for Depressed Patients with Chronic Obstructive Pulmonary Disease (PID-C) is an intervention aiming to help patients adhere to their rehabilitation and care. This study tested the hypothesis that the Problem-Solving Adherence (PSA) intervention, which integrates problem-solving into adherence enhancement procedures, reduces dyspnea-related disability more than PID-C. Exploratory analyses sought to identify patients with distinct dyspnea-related disability trajectories and to compare their clinical profiles...
October 10, 2017: American Journal of Geriatric Psychiatry
Akash Ranjan Singh, Abhijit Pakhare, Arun M Kokane, Hemant Deepak Shewade, Ashish Chauhan, Abhishek Singh, Arti Gangwar, Prahlad Singh Thakur
INTRODUCTION: Community-based direct observed treatment (DOT) providers are an important bridge for the national tuberculosis programme in India to reach the unreached. The present study has explored the knowledge, attitude, practice and barriers perceived by the community-based DOT providers. METHODS: Mixed-methods study design was used among 41 community-based DOT providers (Accredited Social Health Activist (ASHAs)) working in 67 villages from a primary health center in Raisen district of Madhya Pradesh, India...
December 2017: Journal of Epidemiology and Global Health
Arti B Patel, Irene Tsilioni, Zuyi Weng, Theoharis C Theoharides
Psoriasis is an autoimmune skin disease characterized by keratinocyte hyper-proliferation and chronic inflammation. The pathogenesis of psoriasis involves pro-inflammatory cytokines, such as tumor necrosis factor (TNF), but the mechanism of keratinocyte activation is not well understood. Here we show that TNF (10 or 50 ng/mL) stimulates significant (p<0.0001) gene expression and secretion of pro-inflammatory IL-6, CXCL8 and VEGF from both cultured human HaCaT and normal epidermal human keratinocytes (NHEKs)...
November 4, 2017: Experimental Dermatology
Fiona Ehrhardt, Jean-François Soussana, Gianni Bellocchi, Peter Grace, Russel McAuliffe, Sylvie Recous, Renáta Sándor, Pete Smith, Val Snow, Massimiliano D A Migliorati, Bruno Basso, Arti Bhatia, Lorenzo Brilli, Jordi Doltra, Christopher D Dorich, Luca Doro, Nuala Fitton, Sandro J Giacomini, Brian Grant, Matthew T Harrison, Stephanie K Jones, Miko U F Kirschbaum, Katja Klumpp, Patricia Laville, Joël Léonard, Mark Liebig, Mark Lieffering, Raphaël Martin, Raia Silvia Massad, Elizabeth Meier, Lutz Merbold, Andrew D Moore, Vasileios Myrgiotis, Paul Newton, Elizabeth Pattey, Susanne Rolinski, Joanna Sharp, Ward N Smith, Lianhai Wu, Qing Zhang
Simulation models are extensively used to predict agricultural productivity and greenhouse gas (GHG) emissions. However, the uncertainties of (reduced) model ensemble simulations have not been assessed systematically for variables affecting food security and climate change mitigation, within multispecies agricultural contexts. We report an international model comparison and benchmarking exercise, showing the potential of multimodel ensembles to predict productivity and nitrous oxide (N2 O) emissions for wheat, maize, rice and temperate grasslands...
October 28, 2017: Global Change Biology
Shivraj Hariram Nile, Young Soo Keum, Arti Shivraj Nile, Young Deuk Kwon, Doo Hwan Kim
Xanthine oxidase (XO) found in all mammals and excess activity leads to urolithiasis. The cow milk XO was purified to 305-fold with a specific activity of 8.76 EU/mg and overall yield of 87% by using DEAE-Sepharose chromatography. The phenolics showed potent XO inhibitory effect with Ki , P1 (0.412), P2 (0.632), P3 (0.585), P4 (0.886), P5 (1.633), P6 (0.503), P7 (2.882), P8 (3.761), P9 (4.487), and P10 (5.841) μM. The phenolics P9 and P10 exhibited uncompetitive inhibition; the phenolics P1, P2, P3, P4, and P6 showed competitive inhibition, and other phenolic acids showed noncompetitive inhibition...
October 26, 2017: Journal of Biochemical and Molecular Toxicology
Bharat K Kantharia, Surendra K Chutani, Arti N Shah
No abstract text is available yet for this article.
July 2017: Indian Pacing and Electrophysiology Journal
Arti Appannah, Toni Rice, Rajna Ogrin
AIMS: To systematically identify and describe models of injectable therapy initiation for people with type 2 diabetes mellitus (T2DM) in primary care. METHODS: Eight electronic databases and the grey literature were searched. Studies examining models of injectable therapy initiation for adults with T2DM in primary care settings were included. RESULTS: Successful models included: 1) Nurse-led one-to-one approach; 2) Nurse-led group sessions; and 3) Providing education to GPs and nurses...
June 2017: Journal of Clinical & Translational Endocrinology
Arti V Shinde, Nikolaos G Frangogiannis
PURPOSE OF REVIEW: Activated fibroblasts are critically implicated in repair and remodeling of the injured heart. This manuscript discusses recent progress in the cell biology of fibroblasts in the infarcted and remodeling myocardium, highlighting advances in understanding the origin, function and mechanisms of activation of these cells. RECENT FINDINGS: Following myocardial injury, fibroblasts undergo activation and myofibroblast transdifferentiation. Recently published studies have suggested that most activated myofibroblasts in the infarcted and pressure-overloaded hearts are derived from resident fibroblast populations...
June 2017: Current Pathobiology Reports
Arti Bhoutekar, Susmita Ghosh, Swati Bhattacharya, Abhijit Chatterjee
Markov state models (MSMs) and other related kinetic network models are frequently used to study the long-timescale dynamical behavior of biomolecular and materials systems. MSMs are often constructed bottom-up using brute-force molecular dynamics (MD) simulations when the model contains a large number of states and kinetic pathways that are not known a priori. However, the resulting network generally encompasses only parts of the configurational space, and regardless of any additional MD performed, several states and pathways will still remain missing...
October 21, 2017: Journal of Chemical Physics
Naïm Ouldali, Xavier Bellêttre, Karen Milcent, Romain Guedj, Loïc de Pontual, Bogdan Cojocaru, Valérie Soussan-Banini, Irina Craiu, David Skurnik, Vincent Gajdos, Gérard Chéron, Robert Cohen, Corinne Alberti, François Angoulvant
Background: Many antibiotics are prescribed inappropriately in pediatric emergency departments (PEDs), but little data are available in these settings about effective interventions based on guidelines that follow the antimicrobial stewardship principle. Our aim was to assess the impact of implementing the 2011 national guidelines on antibiotic prescriptions for acute respiratory tract infection (ARTI) in PEDs. Method: We conducted a multicentric, quasiexperimental, interrupted time series analysis of prospectively collected electronic data from 7 French PEDs...
October 16, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Tim A Ahles, Arti Hurria
No abstract text is available yet for this article.
October 17, 2017: Psycho-oncology
Ayesha Sadaf, Arti Kumari, S K Khare
Present work reports the inhibition of Bacillus cereus EMB20 β-lactamase by a deep eutectic solvent, maline in an uncompetitive manner. Far-UV CD and intrinsic fluorescence spectroscopy revealed a disrupted secondary as well as tertiary structure as a function of maline concentration. The effect of individual components of maline on β-lactamase inhibition showed that malonic acid was mainly responsible for inhibiting the β-lactamase. Structural and docking studies found that malonic acid led to major perturbations in the secondary and tertiary structure of the enzyme while H-bonding with the active site residues...
October 10, 2017: International Journal of Biological Macromolecules
Akshay Bagai, Maria Eberg, Maria Koh, Asim N Cheema, Andrew T Yan, Arti Dhoot, Sanjeev P Bhavnani, Harindra C Wijeysundera, R Sacha Bhatia, Padma Kaul, Shaun G Goodman, Dennis T Ko
BACKGROUND: The appropriate use criteria considers cardiac stress testing within 2 years after percutaneous coronary intervention (PCI) to be rarely appropriate, unless prompted by symptoms or change in clinical status. Little is known about the patterns of cardiac stress testing after PCI in the single-payer Canadian healthcare system, where mechanisms for reimbursement are different from the United States. METHODS AND RESULTS: Frequency and timing of cardiac stress testing within 2 years of PCI performed between April 2004 and March 2013 in Ontario, Canada, was determined from linked provincial databases...
October 2017: Circulation. Cardiovascular Quality and Outcomes
Enrique Soto-Perez-De-Celis, Heeyoung Kim, María Patricia Rojo-Castillo, Can-Lan Sun, Yanin Chavarri-Guerra, Ana Patricia Navarrete-Reyes, James R Waisman, José Alberto Avila-Funes, Álvaro Aguayo, Arti Hurria
OBJECTIVES: Older adults with cancer in developing countries face challenges accessing healthcare due to a lack of personnel and infrastructure. A decline in physical activity (defined as a decrease in the number of daily steps) may be a novel method for the timely detection of toxicity in older adults receiving chemotherapy in resource-constrained settings. MATERIALS AND METHODS: In this feasibility study, patients aged ≥65years starting first-line chemotherapy for solid tumors were given a smartphone with a pedometer application...
October 7, 2017: Journal of Geriatric Oncology
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