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https://www.readbyqxmd.com/read/28644553/structural-insights-into-the-inclusion-complexes-between-clomiphene-citrate-and-%C3%AE-cyclodextrin-the-mechanism-of-preferential-isomeric-selection
#1
Arti Maheshwari, Harish Saraswat, Santosh Kumar Upadhyay
A major challenge in pharmaceuticals for clinical applications is to alter the solubility, stability, and toxicity of drug molecules in living systems. Cyclodextrins (CDs) have the ability to form host-guest inclusion complexes with pharmaceuticals for further development of new drug formulations. The inclusion complex of clomiphene citrate (CL), a poorly water-soluble drug, with native β-cyclodextrin (β-CD) was characterized by a one and two-dimensional nuclear magnetic resonance (NMR) spectroscopic approach and also by molecular docking techniques...
June 23, 2017: Chirality
https://www.readbyqxmd.com/read/28643006/complications-of-fat-transfer-for-breast-augmentation
#2
Paraskevas Kontoes, George Gounnaris
Autologous fat grafting is quite common for breast augmentations as well as for reconstructive breast surgery. Coleman has described the surgical technique of fat grafting. Fat is harvested, and after centrifugation and refinement, blunt infiltration cannulas are used to place the fat through small incisions. The grafted tissue is placed in small aliquots with each withdrawal of the cannula. In order to achieve an aesthetically pleasing contour of the breast, the fat should be layered into different levels from the chest wall to the skin...
June 22, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28642040/global-geriatric-oncology-achievements-and-challenges
#3
REVIEW
Enrique Soto-Perez-de-Celis, Nienke A de Glas, Tina Hsu, Ravindran Kanesvaran, Christopher Steer, Ana Patricia Navarrete-Reyes, Nicolo Matteo Luca Battisti, Yanin Chavarri-Guerra, Anita O'Donovan, Jose Alberto Avila-Funes, Arti Hurria
The aging of the population is a global challenge. The number of older adults is rapidly growing, leading to an increase in the prevalence of noncommunicable diseases associated with aging, such as cancer. Worldwide, older adults account for approximately half of all cancer cases, and this proportion is projected to increase globally. Furthermore, the majority of older adults live in less developed regions, where health systems are generally ill-equipped to provide care for complex chronic conditions. Worldwide, there is paucity of geriatric training, and most of the oncology workforce lacks the skills and knowledge to provide comprehensive care for older patients...
June 19, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/28632501/evaluation-of-automatic-dose-rate-control-for-flat-panel-imaging-using-a-spatial-frequency-domain-figure-of-merit
#4
Michiel Dehairs, Hilde Bosmans, Walter Desmet, Nicholas W Marshall
Current automatic dose rate controls (ADRCs) of dynamic x-ray imaging systems adjust acquisition parameters in response to changes in patient thickness in order to achieve a constant signal level in the image receptor. This work compares a 3 parameter (3P) ADRC control to a more flexible 5-parameter (5P) method to meet this goal. A phantom composed of 15 composite poly(methyl) methacrylate (PMMA)/aluminium (Al) plates was imaged on a Siemens Artis Q dynamic system using standard 3P and 5P ADRC technique. Phantom thickness covered a water equivalent thickness range of 2...
June 20, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28630625/quantification-of-antioxidant-phenolic-compounds-in-a-new-chrysanthemum-cultivar-by-high-performance-liquid-chromatography-with-diode-array-detection-and-electrospray-ionization-mass-spectrometry
#5
Ah-Reum Han, Hyo Young Kim, Yangkang So, Bomi Nam, Ik-Soo Lee, Joo-Won Nam, Yeong Deuk Jo, Sang Hoon Kim, Jin-Baek Kim, Si-Yong Kang, Chang Hyun Jin
The flowers of Chrysanthemum morifolium Ramat. have been used as an herbal tea and in traditional medicine, and the plant has been developed to produce horticultural cultivars of various colors and shapes. In this study, a new chrysanthemum cultivar with dark purple petals (C. morifolium cv. ARTI-Dark Chocolate; ADC) was developed by radiation-induced mutation breeding of its original cultivar with purple striped white petals (C. morifolium cv. Noble Wine, NW). The phenolic profile and antioxidant property of ADC were investigated and compared with NW and the commercially available medicinal herb, C...
2017: International Journal of Analytical Chemistry
https://www.readbyqxmd.com/read/28620293/a-manual-segmentation-tool-for-three-dimensional-neuron-datasets
#6
Chiara Magliaro, Alejandro L Callara, Nicola Vanello, Arti Ahluwalia
To date, automated or semi-automated software and algorithms for segmentation of neurons from three-dimensional imaging datasets have had limited success. The gold standard for neural segmentation is considered to be the manual isolation performed by an expert. To facilitate the manual isolation of complex objects from image stacks, such as neurons in their native arrangement within the brain, a new Manual Segmentation Tool (ManSegTool) has been developed. ManSegTool allows user to load an image stack, scroll down the images and to manually draw the structures of interest stack-by-stack...
2017: Frontiers in Neuroinformatics
https://www.readbyqxmd.com/read/28620159/main-and-epistatic-loci-studies-in-soybean-for-sclerotinia-sclerotiorum-resistance-reveal-multiple-modes-of-resistance-in-multi-environments
#7
Tara C Moellers, Arti Singh, Jiaoping Zhang, Jae Brungardt, Mehdi Kabbage, Daren S Mueller, Craig R Grau, Ashish Ranjan, Damon L Smith, R V Chowda-Reddy, Asheesh K Singh
Genome-wide association (GWAS) and epistatic (GWES) studies along with expression studies in soybean [Glycine max (L.) Merr.] were leveraged to dissect the genetics of Sclerotinia stem rot (SSR) [caused by Sclerotinia sclerotiorum (Lib.) de Bary], a significant fungal disease causing yield and quality losses. A large association panel of 466 diverse plant introduction accessions were phenotyped in multiple field and controlled environments to: (1) discover sources of resistance, (2) identify SNPs associated with resistance, and (3) determine putative candidate genes to elucidate the mode of resistance...
June 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28618036/ultra-low-radiation-dose-during-electrophysiology-procedures-using-optimised-new-generation-fluoroscopy-technology
#8
James Crowhurst, Haris Haqqani, Daniel Wright, Daniel Wright, Mark Whitby, Adam Lee, John Betts, Russell Denman
BACKGROUND: Electrophysiology procedures require fluoroscopic guidance, with the associated potentially adverse effects of ionising radiation. Newer fluoroscopy systems have more features that enable dose-reduction strategies. This study aimed to investigate any reduction in radiation dose between an older fluoroscopy system (Philips Integris H5000) and one of the latest systems (Siemens Artis Q), optimised with dose-reduction strategies. METHODS: Radiation dose measures were collected over a two year period in a single electrophysiology laboratory...
June 15, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/28613956/effect-of-age-on-the-efficacy-and-safety-of-lenvatinib-in-radioiodine-refractory-differentiated-thyroid-cancer-in-the-phase-iii-select-trial
#9
Marcia S Brose, Francis P Worden, Kate L Newbold, Matthew Guo, Arti Hurria
Purpose In the Study of (E7080) Lenvatinib in Differentiated Cancer of the Thyroid (SELECT), lenvatinib significantly prolonged progression-free survival (PFS) versus placebo in patients with radioiodine-refractory differentiated thyroid cancer (RR-DTC). This prespecified subanalysis investigated the effect of age on the efficacy and safety of lenvatinib. Patients and Methods This randomized, double-blind, phase III study enrolled patients with histologically confirmed RR-DTC stratified by age (≤ 65 or > 65 years)...
June 14, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28602980/suppression-of-akt1-%C3%AE-catenin-pathway-in-advanced-prostate-cancer-promotes-tgf%C3%AE-1-mediated-epithelial-to-mesenchymal-transition-and-metastasis
#10
Fei Gao, Abdulrahman Alwhaibi, Harika Sabbineni, Arti Verma, Wael Eldahshan, Payaningal R Somanath
Akt1 is essential for the oncogenic transformation and tumor growth in various cancers. However, the precise role of Akt1 in advanced cancers is conflicting. Using a neuroendocrine TRansgenic Adenocarcinoma of the Mouse Prostate (TRAMP) model, we first show that the genetic ablation or pharmacological inhibition of Akt1 in mice blunts oncogenic transformation and prostate cancer (PCa) growth. Intriguingly, triciribine (TCBN)-mediated Akt inhibition in 25-week old, tumor-bearing TRAMP mice and Akt1 gene silencing in aggressive PCa cells enhanced epithelial to mesenchymal transition (EMT) and promoted metastasis to the lungs...
June 7, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28602407/improving-consistency-and-quality-of-care-for-older-adults-with-cancer-the-challenges-of-developing-consensus-guidelines-for-radiation-therapy
#11
EDITORIAL
Noam VanderWalde, Arti Hurria, Reshma Jagsi
No abstract text is available yet for this article.
July 15, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28593515/cu-resistant-kocuria-sp-crb15-a-potential-pgpr-isolated-from-the-dry-tailing-of-rakha-copper-mine
#12
Arti Hansda, Vipin Kumar, Anshumali
Rhizobacteria may enhance biomass production and heavy metal tolerance of plants under stress conditions. The present study was carried out for isolation of metal-resistant bacteria that can be further utilized for phytoremediation process. A potential metal-resistant strain CRB15 was isolated from rhizospheric region of Saccharum spontaneum that was found to be resistant against Cu (6.29 mM), Zn (3.25 mM), Pb (1.5 mM), Ni (1.25 mM), and Cd (0.25 mM). SEM analysis was performed for evaluation of morphological changes on bacterial isolate...
June 2017: 3 Biotech
https://www.readbyqxmd.com/read/28584739/profile-of-lymphadenopathy-an-institutional-based-cytomorphological-study
#13
Aneeta Singh Malhotra, Mega Lahori, Arti Nigam, Arvind Khajuria
INTRODUCTION: Lymphadenopathy is one of the most common clinical presentations of patients attending the outdoor department of a hospital. Lymph node aspiration is of great value for the diagnosis of lymphadenitis, lymphomas, and metastatic carcinoma. MATERIALS AND METHODS: In this study, we have reported the pattern of cytological diagnosis on fine-needle aspiration cytology (FNAC) of lymphadenopathy cases in Jammu region of Jammu and Kashmir state of India. The mean age of all the patients in this study was 21...
April 2017: International Journal of Applied and Basic Medical Research
https://www.readbyqxmd.com/read/28578956/synthesis-of-xanthan-gum-graft-copolymer-and-its-application-for-controlled-release-of-highly-water-soluble-levofloxacin-drug-in-aqueous-medium
#14
Ashok Kumar, Deepak, Swati Sharma, Arti Srivastava, Rajesh Kumar
Graft copolymers (XG-g-PNVP-1 to XG-g-PNVP-5) of xanthan gum (XG) and poly(N-vinyl-2-pyrrolidone) (PNVP) was synthesized by free radical polymerization using peroxymonosulphate/thiourea redox pair. The synthesized graft copolymers were well characterized by (1)H NMR, FTIR, XRD, SEM, TGA/DTA and AFM analyses. The optimum conditions for maximum grafting were determined by varying the concentrations of N-vinyl-2-pyrrolidone (NVP) from 10×10(-2) to 18×10(-2)moldm(-3); the grafting ratios increases up to 14×10(-2)moldm(-3), while thereafter decreased...
September 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28576178/updates-in-postmastectomy-radiation
#15
REVIEW
Jean L Wright, Arti Parekh
Although the use of postmastectomy radiation therapy (PMRT) is widely accepted in certain clinical situations, areas of controversy persist for some clinical scenarios. In addition, with significant shifts in the management of breast cancer, including omission of axillary nodal dissection in select sentinel node-positive patients and increased use of neoadjuvant chemotherapy, new clinical challenges have arisen regarding the role of PMRT. This article reviews the data to support current recommendations for postmastectomy radiation and explores areas of controversy and the studies that guide clinicians in these scenarios...
July 2017: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/28571170/financial-burden-of-out-of-pocket-expenditures-for-primary-health-care-in-hilly-areas-of-garhwal-region-uttarakhand-north-india
#16
Arti Gupta, B Venkatashiva Reddy, Vandana Semwal, Amit Kumar Singh
INTRODUCTION: High total health expenditures via Out-of-Pocket (OOP) as formal user fees and informal payments put India in challenging situation to achieve towards universal health coverage. AIM: To assess the (OOP) expenditure and its determinants among outpatient in primary care settings of Uttarakhand, North India. MATERIALS AND METHODS: A hospital based cross-sectional study was conducted in a Outpatient Department of Urban Health Training Centre, Srinagar, Uttarakhand, India and Rural Health Training Centre, Kritinagar, Uttarakhand in 2015...
April 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28569649/antibiotic-prescribing-for-acute-respiratory-tract-infections-in-norwegian-primary-care-out-of-hours-service
#17
Bent H Lindberg, Svein Gjelstad, Mats Foshaug, Sigurd Høye
PURPOSE: To examine factors correlating with antibiotic prescribing for acute respiratory tract infections (ARTIs) in Norwegian primary care out-of-hours service. MATERIALS AND METHODS: Retrospective data analysis for the year 2014 in two out-of-hours primary care units located in the towns of Hamar and Tønsberg in Norway, analysing type and frequency of different antibiotics prescribed by 117 medical doctors for ARTIs, and factors correlating with these. RESULTS: The 117 doctors in two out-of-hours units diagnosed 6757 cases of ARTIs...
June 1, 2017: Scandinavian Journal of Primary Health Care
https://www.readbyqxmd.com/read/28562233/relationship-of-phosphodiesterase-4d-pde4d-gene-polymorphisms-with-risk-of-ischemic-stroke-a-hospital-based-case-control-study
#18
Amit Kumar, Shubham Misra, Pradeep Kumar, Ram Sagar, Arti Gulati, Kameshwar Prasad
BACKGROUND: Stroke remains a leading cause of death and disability worldwide. Ischemic stroke (IS) accounts for around 80-85% of total stroke and is a complex polygenic multi-factorial disorder which is affected by a complex combination of vascular, environmental, and genetic factors. OBJECTIVE: The study was conducted with an aim to examine the relationship of single nucleotide polymorphisms (SNPs) of PDE4D (T83C, C87T, and C45T) gene with increasing risk of IS in patients in North Indian population...
May 31, 2017: Neurological Research
https://www.readbyqxmd.com/read/28559409/association-of-pre-chemotherapy-peripheral-blood-pro-inflammatory-and-coagulation-factors-with-physical-function-in-women-with-breast-cancer
#19
Yuan Yuan, Nilesh Vora, Can-Lan Sun, Daneng Li, David Smith, Joanne Mortimer, The-Hang Luu, George Somlo, James Waisman, Joseph Chao, Vani Katheria, Timothy Synold, Vivi Tran, Shu Mi, Tao Feng, Abrahm Levi, Anait Arsenyan, Jennifer Choi, Laura Zavala, Susan Yost, Arti Hurria
BACKGROUND: Pro-inflammatory and coagulation factors serve as biomarkers of aging and functional reserve. The purpose of this study was to determine if pro-inflammatory (interleukin-6 [IL-6], C-reactive protein [CRP]), and coagulation (D-dimer) factors were associated with pre-chemotherapy functional status in women with stage I-III breast cancer. PATIENTS AND METHODS: Prior to chemotherapy initiation in patients with stage I-III breast cancer, the following was captured: IL-6, CRP, D-dimer blood levels, and physical function measures including activities of daily living (ADL, subscale of Medical Outcomes Study Physical Health); instrumental activities of daily living (IADL, subscale of the Older Americans Resources and Services Program); Timed Up and Go (TUG); physician-rated Karnofsky Performance Status (KPS); and self-rated KPS...
May 30, 2017: Oncologist
https://www.readbyqxmd.com/read/28557755/validation-of-new-quality-measures-for-transitions-between-sites-of-care
#20
Layla Parast, Q Burkhart, Arti D Desai, Tamara D Simon, Carolyn Allshouse, Maria T Britto, JoAnna K Leyenaar, Courtney A Gidengil, Sara L Toomey, Marc N Elliott, Eric C Schneider, Rita Mangione-Smith
BACKGROUND AND OBJECTIVE: Assessing and improving the quality of transitions to home from the emergency department (ED) or hospital is critical for patient safety. Our objective was to validate 8 newly developed caregiver-reported measures of transition quality. METHODS: This prospective observational study included 1086 caregiver survey respondents whose children had an ED visit (n = 523) or hospitalization (n = 563) at Seattle Children's Hospital in 2014. Caregivers were contacted to complete 2 surveys...
May 2017: Pediatrics
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