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https://www.readbyqxmd.com/read/27925273/biochemical-response-of-the-africanized-honeybee-exposed-to-fipronil
#1
Thaisa C Roat, Stephan M Carvalho, Mário S Palma, Osmar Malaspina
Bees are recognized worldwide for their social, economic, and environmental value; however, they have been seriously threatened in recent decades by diseases and by high levels of pesticide use. The susceptibility of bees to insecticides makes them an important terrestrial model for assessing environmental quality, and various biomarkers have been developed for these assessments. The present study aimed to evaluate the activity of the enzymes acetylcholinesterase (AChE), carboxylesterase (CaE), and glutathione S-transferase (GST) in Africanized honeybees exposed to fipronil...
December 7, 2016: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/27895113/age-dependent-absolute-abundance-of-hepatic-carboxylesterases-ces1-and-ces2-by-lc-ms-ms-proteomics-application-to-pbpk-modeling-of-oseltamivir-in-vivo-pharmacokinetics-in-infants
#2
Mikael Boberg, Marc Vrana, Aanchal Mehrotra, Robin E Pearce, Andrea Gaedigk, Deepak Kumar Bhatt, J Steven Leeder, Bhagwat Prasad
The age-dependent absolute protein abundance of carboxylesterase 1 and 2 (CES1 and CES2) in human liver was investigated and applied to predict infant pharmacokinetics (PK) of oseltamivir. The CES absolute protein abundance was determined by LC-MS/MS proteomics in human liver microsomal and cytosolic fractions prepared from tissue samples obtained from 136 pediatric and 35 adult donors. Two surrogate peptides per protein were selected for the quantification of CES1 and CES2 protein abundance. Purified CES1 and CES2 protein standards were used as calibrators, and the heavy labeled peptides were used as the internal standards...
November 28, 2016: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/27881673/sortilin-1-modulates-hepatic-cholesterol-lipotoxicity-in-mice-via-functional-interaction-with-liver-carboxylesterase-1
#3
Jibiao Li, Yifeng Wang, David Matye, Hemantkumar Chavan, Partha Krishnamurthy, Feng Li, Tiangang Li
Liver plays a key role in cholesterol metabolism. Impaired hepatic cholesterol homeostasis causes intracellular free cholesterol accumulation and hepatocyte injury. Sortilin 1 (Sort1) is an intracellular lysosomal trafficking receptor that was recently identified by GWAS as a novel regulator of cholesterol metabolism in humans. Here we report that Sort1 deficiency protected against cholesterol accumulation-induced liver injury and inflammation in mice. Using LC-MS/MS based proteomics approach, we identified liver carboxyesterase 1 (CES1) as a novel Sort1 interacting protein...
November 23, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27831961/nomenclature-for-alleles-of-the-human-carboxylesterase-1-gene
#4
Henrik B Rasmussen, Majbritt B Madsen, Peter R Hansen
No abstract text is available yet for this article.
November 9, 2016: Pharmacogenetics and Genomics
https://www.readbyqxmd.com/read/27800573/pharmacokinetic-modeling-and-monte-carlo-simulation-to-predict-interindividual-variability-in-human-exposure-to-oseltamivir-and-its-active-metabolite-ro-64-0802
#5
Mototsugu Ito, Hiroyuki Kusuhara, Atsushi Ose, Tsunenori Kondo, Kazunari Tanabe, Hideki Nakayama, Shigeru Horita, Takuya Fujita, Yuichi Sugiyama
Oseltamivir (Tamiflu®) is a prodrug of Ro 64-0802, a selective inhibitor of influenza virus neuraminidase. There is a possible relationship between oseltamivir treatment and neuropsychiatric adverse events; although this has not been established, close monitoring is recommended on the prescription label. The objective of this study was to predict interindividual variability of human exposure to oseltamivir and its active metabolite Ro 64-0802. By leveraging mathematical models and computations, physiological parameters in virtual subjects were generated with population means and coefficient of variations collected from the literature or produced experimentally...
October 31, 2016: AAPS Journal
https://www.readbyqxmd.com/read/27771568/effect-of-surfactant-in-mitigating-cadmium-oxide-nanoparticle-toxicity-implications-for-mitigating-cadmium-toxicity-in-environment
#6
Sricharani Rao Balmuri, Uthra Selvaraj, Vadivel Vinod Kumar, Savarimuthu Philip Anthony, Aristides Michael Tsatsakis, Kirill Sergeevich Golokhvast, Thiagarajan Raman
Cadmium (Cd), classified as human carcinogen, is an extremely toxic heavy metal pollutant, and there is an increasing environmental concern for cadmium exposure through anthropogenic sources including cigarette smoke. Though Cd based nanoparticles such as cadmium oxide (CdO) are being widely used in a variety of clinical and industrial applications, the toxicity of CdO nanoparticles has not been well characterized. Herein we report the toxicity of CdO nanoparticles employing zebrafish as a model. Two different CdO nanoparticles were prepared, calcination of Cd(OH)2 without any organic molecule (CdO-1) and calcination of Cd-citrate coordination polymer (CdO-2), to evaluate and compare the toxicity of these two different CdO nanoparticles...
January 2017: Environmental Research
https://www.readbyqxmd.com/read/27754602/population-pharmacokinetics-of-methylphenidate-in-healthy-adults-emphasizing-novel-and-known-effects-of-several-carboxylesterase-1-ces1-variants
#7
Y K Lyauk, C Stage, T K Bergmann, L Ferrero-Milliani, D Bjerre, R Thomsen, K P Dalhoff, H B Rasmussen, G Jürgens
The aim of this study was to identify demographic and genetic factors that significantly affect methylphenidate (MPH) pharmacokinetics (PK), and may help explain interindividual variability and further increase the safety of MPH. d-MPH plasma concentrations, demographic covariates, and carboxylesterase 1 (CES1) genotypes were gathered from 122 healthy adults and analyzed using nonlinear mixed effects modeling. The structural model that best described the data was a two-compartment disposition model with absorption transit compartments...
December 2016: Clinical and Translational Science
https://www.readbyqxmd.com/read/27733453/a-linkage-map-and-qtl-analysis-for-pyrethroid-resistance-in-the-bed-bug-cimex-lectularius
#8
Toby Fountain, Mark Ravinet, Richard Naylor, Klaus Reinhardt, Roger K Butlin
The rapid evolution of insecticide resistance remains one of the biggest challenges in the control of medically and economically important pests. Insects have evolved a diverse range of mechanisms to reduce the efficacy of the commonly used classes of insecticides and finding the genetic basis of resistance is a major aid to management. In a previously unstudied population, we performed an F2 resistance mapping cross for the common bed bug, Cimex lectularius, for which insecticide resistance is increasingly widespread...
October 12, 2016: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/27728890/cyromazine-resistance-in-a-field-strain-of-house-flies-musca-domestica-l-resistance-risk-assessment-and-bio-chemical-mechanism
#9
Hafiz Azhar Ali Khan, Waseem Akram
Developing resistance management strategies for eco-friendly insecticides is essential for the management of insect pests without harming the environment. Cyromazine is a biorational insecticide with very low mammalian toxicity. Resistance to cyromazine has recently been reported in house flies from Punjab, Pakistan. In order to propose a resistance management strategy for cyromazine, experiments were planned to study risk for resistance development, possibility of cross-resistance and bio-chemical mechanisms...
October 8, 2016: Chemosphere
https://www.readbyqxmd.com/read/27723570/in-vitro-and-in-vivo-studies-of-cholinesterases-and-carboxylesterases-in-planorbarius-corneus-exposed-to-a-phosphorodithioate-insecticide-finding-the-most-sensitive-combination-of-enzymes-substrates-tissues-and-recovery-capacity
#10
Sofía Otero, Gisela Kristoff
Organophosphate insecticides (OPs) continue to be an important class of agrochemicals used in modern agriculture worldwide. Even though these pesticides persist in the environment for a relatively short time, they show a high acute toxicity that may represent a serious hazard for wildlife. Sub-lethal effects on non-target species are a focus in pest management programs and should be used as biomarkers. Cholinesterases (ChEs) are the most used biomarker of OP exposure in vertebrate and invertebrate species. However, the combined monitoring of ChE and carboxylesterase (CE) activities may provide a more useful indication of exposure and effect of the organisms...
October 6, 2016: Aquatic Toxicology
https://www.readbyqxmd.com/read/27720728/cloning-of-two-carboxylesterase-cdnas-from-the-swimming-crab-portunus-trituberculatus-molecular-evidences-for-their-putative-roles-in-methyl-farnesotae-degradation
#11
Tian Tao, Xi Xie, Mingxin Liu, Qinghua Jiang, Dongfa Zhu
The sesquiterpenoid methyl farnesoate (MF) is the unepoxidized form of insect juvenile hormone (JH) III, and is considered an equivalent of JH in crustaceans. Degradation of MF is similar to that of JH which occurs through ester hydrolysis by specific carboxylesterases (CXEs). In this study, the full-length cDNAs of two JH esterase-like CXEs were cloned from the swimming crab, Portunus trituberculatus. The predicted amino acid sequences of the two PtCXEs contain the conserved motifs including catalytic triad and oxyanion hole, which are the hallmark of the CXE family proteins...
October 5, 2016: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/27717121/molecular-characterisation-of-two-%C3%AE-esterase-genes-involving-chlorpyrifos-detoxification-in-the-diamondback-moth-plutella-xylostella
#12
Miao Xie, Na-Na Ren, Yan-Chun You, Wei-Jun Chen, Qi-Sheng Song, Min-Sheng You
BACKGROUND: Carboxylesterases (CarEs) are involved in metabolic detoxification of dietary and environmental xenobiotics in insects. However, owing to the complexity of the protein family, the involvement of CarEs in insecticide metabolism in Plutella xylostella has not been fully elucidated. This study aimed to characterise two CarE genes and assess their potential roles in response to chlorpyrifos in P. xylostella. RESULTS: Synergistic tests showed that triphenyl phosphate decreased the resistance of the third-instar larvae to chlorpyrifos...
September 22, 2016: Pest Management Science
https://www.readbyqxmd.com/read/27711198/health-status-of-sand-flathead-platycephalus-bassensis-inhabiting-an-industrialised-and-urbanised-embayment-port-phillip-bay-victoria-as-measured-by-biomarkers-of-exposure-and-effects
#13
Jarrad K Baker, Sara M Long, Kathryn L Hassell, Vincent J Pettigrove, Marthe M Gagnon
Port Phillip Bay, Australia, is a large semi-closed bay with over four million people living in its catchment basin. The Bay receives waters from the Yarra River which drains the city of Melbourne, as well as receiving the discharges of sewage treatment plants and petrochemical and agricultural chemicals. A 1999 study demonstrated that fish inhabiting Port Phillip Bay showed signs of effects related to pollutant exposure despite pollution management practices having been implemented for over a decade. To assess the current health status of the fish inhabiting the Bay, a follow up survey was conducted in 2015...
2016: PloS One
https://www.readbyqxmd.com/read/27709014/role-of-farnesoid-x-receptor-in-establishment-of-ontogeny-of-phase-i-drug-metabolizing-enzyme-genes-in-mouse-liver
#14
Lai Peng, Stephanie Piekos, Grace L Guo, Xiao-Bo Zhong
The expression of phase-I drug metabolizing enzymes in liver changes dramatically during postnatal liver maturation. Farnesoid X receptor (FXR) is critical for bile acid and lipid homeostasis in liver. However, the role of FXR in regulating ontogeny of phase-I drug metabolizing genes is not clear. Hence, we applied RNA-sequencing to quantify the developmental expression of phase-I genes in both Fxr-null and control (C57BL/6) mouse livers during development. Liver samples of male C57BL/6 and Fxr-null mice at 6 different ages from prenatal to adult were used...
September 2016: Acta Pharmaceutica Sinica. B
https://www.readbyqxmd.com/read/27702666/identification-and-characterization-of-naturally-occurring-inhibitors-against-human-carboxylesterase-2-in-white-mulberry-root-bark
#15
Ya-Jing Liu, Shi-Yang Li, Jie Hou, Yan-Fang Liu, Dan-Dan Wang, Yong-Shan Jiang, Guang-Bo Ge, Xin-Miao Liang, Ling Yang
White Mulberry Root-bark (WMR) is an edible Chinese herbal used for the treatment of inflammation, nephritis and asthma. This study aimed to investigate the inhibitory effects of ethanol extract from WMR against human carboxylesterase 2 (hCE2), as well as to identity and character natural hCE2 inhibitors in this herbal. Our results demonstrated that the ethanol extract of WMR displayed potent inhibitory effects against hCE2, while three major bioactive constitutes in WMR were identified on the basis of LC fingerprinting combined with activity-based screening of LC fractions...
October 1, 2016: Fitoterapia
https://www.readbyqxmd.com/read/27697378/carboxylesterase-involved-metabolism-of-di-n-butyl-phthalate-in-pumpkin-cucurbita-moschata-seedlings
#16
Qingqi Lin, Siyuan Chen, Yuanqing Chao, Xiongfei Huang, Shizhong Wang, Rongliang Qiu
Uptake and accumulation by plants is a significant pathway in the migration and transformation of phthalate esters (PAEs) in the environment. However, limited information is available on the mechanisms of PAE metabolism in plants. Here, we investigated the metabolism of di-n-butyl phthalate (DnBP), one of the most frequently detected PAEs, in pumpkin (Cucurbita moschata) seedlings via a series of hydroponic experiments with an initial concentration of 10 mg L(-1). DnBP hydrolysis occurred primarily in the root, and two of its metabolites, mono-n-butyl phthalate (MnBP) and phthalic acid (PA), were detected in all plant tissues...
January 2017: Environmental Pollution
https://www.readbyqxmd.com/read/27696958/function-and-application-of-a-non-ester-hydrolyzing-carboxylesterase-discovered-in-tulip
#17
Taiji Nomura
Plants have evolved secondary metabolite biosynthetic pathways of immense rich diversity. The genes encoding enzymes for secondary metabolite biosynthesis have evolved through gene duplication followed by neofunctionalization, thereby generating functional diversity. Emerging evidence demonstrates that some of those enzymes catalyze reactions entirely different from those usually catalyzed by other members of the same family; e.g. transacylation catalyzed by an enzyme similar to a hydrolytic enzyme. Tuliposide-converting enzyme (TCE), which we recently discovered from tulip, catalyzes the conversion of major defensive secondary metabolites, tuliposides, to antimicrobial tulipalins...
October 4, 2016: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/27695062/third-generation-sequencing-and-analysis-of-four-complete-pig-liver-esterase-gene-sequences-in-clones-identified-by-screening-bac-library
#18
Qiongqiong Zhou, Wenjuan Sun, Xiyan Liu, Xiliang Wang, Yuncai Xiao, Dingren Bi, Jingdong Yin, Deshi Shi
AIM: Pig liver carboxylesterase (PLE) gene sequences in GenBank are incomplete, which has led to difficulties in studying the genetic structure and regulation mechanisms of gene expression of PLE family genes. The aim of this study was to obtain and analysis of complete gene sequences of PLE family by screening from a Rongchang pig BAC library and third-generation PacBio gene sequencing. METHODS: After a number of existing incomplete PLE isoform gene sequences were analysed, primers were designed based on conserved regions in PLE exons, and the whole pig genome used as a template for Polymerase chain reaction (PCR) amplification...
2016: PloS One
https://www.readbyqxmd.com/read/27664371/effect-of-diet-on-carboxylesterase-activity-of-tadpoles-rhinella-arenarum-exposed-to-chlorpyrifos
#19
A M Attademo, J C Sanchez-Hernandez, R C Lajmanovich, P M Peltzer, C Junges
An outdoor microcosm was performed with tadpoles (Rhinella arenarum) exposed to 125μgL(-1) chlorpyrifos and fed two types of food, i.e., lettuce (Lactuca sativa) and a formulated commercial pellet. Acetylcholinesterase (AChE) and carboxylesterase (CbE) activities were measured in liver and intestine after 10 days of pesticide exposure. Non-exposed tadpoles fed lettuce had an intestinal AChE activity almost two-fold higher than that of pellet-fed tadpoles. No significant differences were observed, however, in liver AChE activity between diets...
September 21, 2016: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/27662362/pharmacodynamic-impact-of-carboxylesterase-1-gene-variants-in-patients-with-congestive-heart-failure-treated-with-angiotensin-converting-enzyme-inhibitors
#20
Karl Emil Nelveg-Kristensen, Peter Bie, Laura Ferrero, Ditte Bjerre, Niels E Bruun, Martin Egfjord, Henrik B Rasmussen, Peter R Hansen
BACKGROUND: Variation in the carboxylesterase 1 gene (CES1) may contribute to the efficacy of ACEIs. Accordingly, we examined the impact of CES1 variants on plasma angiotensin II (ATII)/angiotensin I (ATI) ratio in patients with congestive heart failure (CHF) that underwent ACEI dose titrations. Five of these variants have previously been associated with drug response or increased CES1 expression, i.e., CES1 copy number variation, the variant of the duplicated CES1 gene with high transcriptional activity, rs71647871, rs2244613, and rs3815583...
2016: PloS One
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