keyword
https://read.qxmd.com/read/38534664/efficacy-of-continuous-vs-intermittent-administration-of-cefepime-in-adult-icu-patients-with-gram-negative-bacilli-bacteremia-a-randomized-double-blind-clinical-study
#1
JOURNAL ARTICLE
Carlos Arturo Álvarez-Moreno, Laura Cristina Nocua-Báez, Guillermo Ortiz, Juan Carlos Torres, Gabriel Montenegro, Williams Cervera, Luis Fernando Zuluaga, Alonso Gómez
INTRODUCTION: The objective of this study was to compare the continuous infusion of cefepime with the intermittent infusion in patients with sepsis caused by Gram-negative bacilli (GNB). METHODS: Randomized 1:1 multicenter double-blinded placebo-controlled study with allocation concealment; multicenter study in the intensive care units of Colombia. Patients with sepsis, severe sepsis or septic shock, and GNB-suspected bacteremia. Cefepime was administered for 7 to 14 days over 30 m intermittently every 8 h over 24 h plus continuous saline solution (0...
February 29, 2024: Antibiotics
https://read.qxmd.com/read/38534389/harnessing-extracellular-micrornas-for-diagnostics-and-therapeutics-in-acute-systemic-inflammation
#2
REVIEW
Russell Hollis, Monowar Aziz, Asha Jacob, Ping Wang
Micro-ribonucleic acids (miRNAs) are small sequences of genetic materials that are primarily transcribed from the intronic regions of deoxyribonucleic acid (DNAs), and they are pivotal in regulating messenger RNA (mRNA) expression. miRNAs were first discovered to regulate mRNAs of the same cell in which they were transcribed. Recent studies have unveiled their ability to traverse cells, either encapsulated in vesicles or freely bound to proteins, influencing distant recipient cells. Activities of extracellular miRNAs have been observed during acute inflammation in clinically relevant pathologies, such as sepsis, shock, trauma, and ischemia/reperfusion (I/R) injuries...
March 19, 2024: Cells
https://read.qxmd.com/read/38531552/infectious-purpura-fulminans-associated-with-pneumococcal-septicaemia-in-a-patient-with-unacknowledged-functional-asplenia
#3
JOURNAL ARTICLE
Savannah Duus, Sanne Jespersen, Christian Wejse
Purpura fulminans (PF) is a life-threatening complication of septic shock that can occur due to disseminated infections with Streptococcus pneumoniae The spleen is an important organ in the immunisation process against encapsulated bacteria. Patients with asplenia, either functional or anatomical, are therefore at increased risk of developing serious infections and complications, such as PF, if infected with such bacteria.This case report presents a woman in her late 40s with unacknowledged functional asplenia who was admitted to the hospital with signs of an acute disseminated infection causing septic shock, signs of disseminated intravascular coagulation and infectious PF...
March 25, 2024: BMJ Case Reports
https://read.qxmd.com/read/38529465/a-case-report-of-neuro-beh%C3%A3-et-syndrome-frequent-neurological-manifestations-concurrent-with-life-threatening-illnesses
#4
Omar Ballut, Mayas M Almahi, Banan S Alghamdi, Najla K Alzahrani, Maali A Alghamdi
​​​​Behçet disease (BD) is a recurrent, multisystemic autoimmune vasculitis that affects both small and large vessels. A combination of neurological signs and symptoms in BD is called neuro-Behçet syndrome (NBS). We present the case of a 31-year-old male diagnosed with chronic progressive NBS who presented with multiple relapsing episodes concurrent with infective endocarditis due to intravenous drug abuse, drug-induced hepatitis, acute kidney injury, and septic shock that is not related to BD...
February 2024: Curēus
https://read.qxmd.com/read/38529316/impact-of-covid-status-and-blood-group-on-complications-in-patients-in-hemorrhagic-shock
#5
JOURNAL ARTICLE
Jason Bradley Brill, Krislynn M Mueck, Madeline E Cotton, Brian Tang, Mariela Sandoval, Lillian S Kao, Bryan A Cotton
OBJECTIVE: Among critically injured patients of various blood groups, we sought to compare survival and complication rates between COVID-19-positive and COVID-19-negative cohorts. BACKGROUND: SARS-CoV-2 infections have been shown to cause endothelial injury and dysfunctional coagulation. We hypothesized that, among patients with trauma in hemorrhagic shock, COVID-19-positive status would be associated with increased mortality and inpatient complications. As a secondary hypothesis, we suspected group O patients with COVID-19 would experience fewer complications than non-group O patients with COVID-19...
2024: Trauma Surgery & Acute Care Open
https://read.qxmd.com/read/38528351/diagnostic-and-prognostic-value-of-pentraxin-3-interleukin-6-crp-and-procalcitonin-levels-in-patients-with-sepsis-and-septic-shock
#6
JOURNAL ARTICLE
B Palalıoğlu, S Erdoğan, G Atay, H C Tugrul, Ö F Özer
INTRODUCTION AND PURPOSE: In this prospective study, we aim to evaluate the effects of antibiotherapy on pentraxin-3 (PTX3), C-reactive protein (CRP), and interleukin-6 (IL-6) levels in patients with sepsis and septic shock. MATERIALS AND METHODS: In our study, CRP, procalcitonin, IL-6, and PTX3 levels at initial and 48 hours of the antibiotherapy of patients who were admitted to the pediatric intensive care unit (PICU) with the diagnosis of sepsis and septic shock between June 2020 and March 2021 were compared...
March 1, 2024: Nigerian Journal of Clinical Practice
https://read.qxmd.com/read/38527992/the-influence-of-sepsis-on-erythrocytes-morphology-case-report-and-literature-review
#7
JOURNAL ARTICLE
Cristian Mircea Nicolescu, Silviu Daniel Moldovan
This paper highlights a clinical case of sepsis caused by soft tissue infection. Peripheral blood smear, plasma value of inflammatory biomarkers and the white blood cells count were performed. Significant morphological changes were revealed through peripheral blood smear test two days after patient admission. Patient developed septic shock after the third day in intensive care unit (ICU). Laboratory results showed major morphological changes (erythrocytes deformity, abnormal neutrophils); these were correlated with elevated plasma value of interleukin-6 and procalcitonin...
2024: Romanian Journal of Morphology and Embryology
https://read.qxmd.com/read/38526166/buena-vista-a-promising-outlook-on-targeting-immune-checkpoint-regulators-to-combat-sepsis
#8
JOURNAL ARTICLE
Madeline D Mott, Briana Trusiano, Irving Coy Allen
No abstract text is available yet for this article.
March 25, 2024: Journal of Leukocyte Biology
https://read.qxmd.com/read/38526162/mdivi-1-alleviates-sepsis-induced-liver-injury-by-inhibiting-sting-signaling-activation
#9
JOURNAL ARTICLE
Qin Zhang, Zhuanhua Liu, Xiaoxia Huang, Xin Heng, Jie Wu, Zhenfeng Chen, Xiaohua Guo, Jun Fan, Qiaobing Huang
Pro-inflammatory hyperactivation of kupffer cells (KCs) is foremost involved in the pathogenesis of sepsis-induced liver injury. Our previous study found that stimulator of interferon genes (STING) signaling was activated in KCs in response of lipopolysaccharide (LPS) and knocking down dynamin-related protein 1 (DRP1) in KCs effectively inhibited the activation of STING signaling and the subsequent production of pro-inflammatory cytokines. In this study, we demonstrated that in vivo treatment with mitochondrial division inhibitor 1 (Mdivi-1), a selective inhibitor of DRP1, alleviated cecal ligation and puncture (CLP)-induced liver injury with the improvement of liver pathology and function...
March 25, 2024: Shock
https://read.qxmd.com/read/38526151/unveiling-the-causal-association-between-non-infectious-respiratory-disorders-and-sepsis-through-mendelian-randomization-analysis
#10
JOURNAL ARTICLE
Cheng Liu, Li He, Xiangde Zheng
BACKGROUND: The association between sepsis and non-infectious respiratory diseases is well-documented, yet the specific causal link between the two remains unclear. In order to explore this relationship further, we employed a Mendelian randomization (MR) analysis utilizing data from the UK Biobank and FinnGen Biobank. METHODS: We analyzed the summary statistics of a genome-wide association study (GWAS) summary statistics for chronic obstructive pulmonary disease (COPD), asthma, pulmonary embolism (PE), idiopathic pulmonary fibrosis (IPF), obstructive sleep apnea (OSA), lung cancer, sepsis, and sepsis-related mortality...
March 25, 2024: Shock
https://read.qxmd.com/read/38525759/hemophagocytic-lymphohistiocytosis-hlh-in-patients-with-tick-borne-illness-a-scoping-review-of-98-cases
#11
REVIEW
Dorde Jevtic, Marilia Dagnon da Silva, Alberto Busmail Haylock, Charles W Nordstrom, Stevan Oluic, Nikola Pantic, Milan Nikolajevic, Nikola Nikolajevic, Magdalena Kotseva, Igor Dumic
Hemophagocytic lymphohistiocytosis (HLH) secondary to tick-borne infections is a rare but potentially life-threatening syndrome. We performed a scoping review according to PRISMA guidelines to systematically analyze the existing literature on the topic. A total of 98 patients were included, with a mean age of 43.7 years, of which 64% were men. Most cases, 31%, were reported from the USA. Immunosuppression was present in 21.4%, with the most common cause being previous solid organ transplantation. Constitutional symptoms were the most common, observed in 83...
February 21, 2024: Infectious Disease Reports
https://read.qxmd.com/read/38524768/culture-free-biphasic-approach-for-early-sepsis-detection-a-true-game-changer
#12
JOURNAL ARTICLE
Hasan Mushahid, Sanila Mughal, Muhammad O Sonija, Ayesha Liaquat
No abstract text is available yet for this article.
March 2024: Health Science Reports
https://read.qxmd.com/read/38524515/significant-risk-factors-for-intensive-care-unit-acquired-weakness-a-processing-strategy-based-on-repeated-machine-learning
#13
JOURNAL ARTICLE
Ling Wang, Deng-Yan Long
BACKGROUND: Intensive care unit-acquired weakness (ICU-AW) is a common complication that significantly impacts the patient's recovery process, even leading to adverse outcomes. Currently, there is a lack of effective preventive measures. AIM: To identify significant risk factors for ICU-AW through iterative machine learning techniques and offer recommendations for its prevention and treatment. METHODS: Patients were categorized into ICU-AW and non-ICU-AW groups on the 14th day post-ICU admission...
March 6, 2024: World Journal of Clinical Cases
https://read.qxmd.com/read/38524344/anatomical-outcome-of-laser-treatment-alone-in-aggressive-retinopathy-of-prematurity
#14
JOURNAL ARTICLE
Anamika Dwivedi, Deepak Dwivedi, Sujata Lakhtakia, Chalisgaonkar Charudutt
PURPOSE: The purpose is to study the anatomical outcome of eyes in aggressive retinopathy of prematurity (AROP), treated with laser photocoagulation alone and to evaluate factors affecting outcomes. METHODS: Records of consecutive babies diagnosed with AROP, undergoing laser photocoagulation treatment in rural tertiary care centers from October 2016 to January 2021 were reviewed retrospectively. Anatomical outcome at 6 months follow-up was grouped as good in eyes with complete regression and poor in those who developed retinal detachment (stage IV a, IV b, and V)...
2024: Oman Journal of Ophthalmology
https://read.qxmd.com/read/38523937/determining-the-association-between-the-origin-of-sepsis-and-the-severity-of-sepsis-in-intensive-care-unit-icu-patients-using-acute-physiology-and-chronic-health-evaluation-apache-iv
#15
JOURNAL ARTICLE
Antony J Arumairaj, Imnett Habtes, Hansang Park, Julio C Valencia-Manrique, Jennifer Arzu, Joseph Mattana, Shobhana Chaudhari, Natoushka Trenard, Thomas Newman
Objective The objective of this study is to compare the outcomes of hospital mortality, the requirement of invasive ventilation, vasopressor requirement, duration of vasopressor requirement, and duration of intensive care unit (ICU) stay among the different causes of sepsis and to determine which cause of sepsis had the most severe outcomes. Methods A retrospective chart review was done in critically ill adult patients who were admitted with sepsis to the ICU from July 2017 until July 2019. Acute Physiology and Chronic Health Evaluation (APACHE) IV scores were calculated on patients admitted to ICU on day one of ICU admission...
February 2024: Curēus
https://read.qxmd.com/read/38523060/immunomodulatory-drugs-in-sepsis-a-systematic-review-and-meta-analysis
#16
REVIEW
R C Robey, C Logue, C A Caird, J Hansel, T P Hellyer, J Simpson, P Dark, A G Mathioudakis, T Felton
Dysregulation of the host immune response has a central role in the pathophysiology of sepsis. There has been much interest in immunomodulatory drugs as potential therapeutic adjuncts in sepsis. We conducted a systematic review and meta-analysis of randomised controlled trials evaluating the safety and clinical effectiveness of immunomodulatory drugs as adjuncts to standard care in the treatment of adults with sepsis. Our primary outcomes were serious adverse events and all-cause mortality. Fifty-six unique, eligible randomised controlled trials were identified, assessing a range of interventions including cytokine inhibitors; anti-inflammatories; immune cell stimulators; platelet pathway inhibitors; and complement inhibitors...
March 24, 2024: Anaesthesia
https://read.qxmd.com/read/38521074/updated-criteria-for-paediatric-sepsis-and-septic-shock
#17
JOURNAL ARTICLE
Priya Venkatesan
No abstract text is available yet for this article.
April 2024: Lancet Infectious Diseases
https://read.qxmd.com/read/38518545/advances-in-pediatric-emergency-from-2023
#18
REVIEW
Joshua S Easter, Emily Rose
Most children receive emergency care by general emergency physicians and not in designated children's hospitals. There are unique considerations in the care of children that differ from the care of adults. Many management principles can be extrapolated from adult studies, but the unique pathophysiology of pediatric disease requires specialized attention and management updates. This article highlights ten impactful articles from the year 2023 whose findings can improve the care of children in the Emergency Department (ED)...
March 15, 2024: American Journal of Emergency Medicine
https://read.qxmd.com/read/38518050/evaluating-the-predictive-value-of-initial-lactate-albumin-ratios-in-determining-prognosis-of-sepsis-patients
#19
JOURNAL ARTICLE
Jianhua Hu, Qun Jin, Honglong Fang, Weiwen Zhang
Sepsis remains a significant clinical challenge owing to its complex pathophysiology and variable prognosis. The early identification of patients at a higher risk of poor outcomes can be crucial for improving treatment strategies. This study aimed to evaluate the predictive value of early serum lactate and albumin levels and the lactate/albumin (L/A) ratio for 28-day prognosis in patients with sepsis. Patients diagnosed with sepsis between January 2021 and December 2022 were evaluated using a retrospective cohort methodology...
March 22, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38518030/the-evolution-of-sepsis-publications-and-global-productivity-a-bibliometric-analysis-between-1980-and-2020
#20
JOURNAL ARTICLE
Arzu Akdagli Ekici, Alperen Kisa, Semin Önder Turhan
The literature study was conducted by using the Web of Science (WoS) database, employing bibliometric analysis to examine all papers released from 1980 to 2020. The search was performed using the terms "sepsis, septicemia, septic shock" specifically within the titles of the publications. The findings of the literature research revealed a total of 51,725 articles. Out of the total number of publications, 26,896 articles were identified, accounting for 51.9% of the total. The bibliometric study revealed that the United States had the largest number of papers (8693), followed by China (2807), Germany (2299), France (1606), and the United Kingdom (1932)...
March 22, 2024: Medicine (Baltimore)
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