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Diabetes,diabetic retinopathy

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https://www.readbyqxmd.com/read/29453673/optical-coherence-tomography-angiography-discerns-preclinical-diabetic-retinopathy-in-eyes-of-patients-with-type-2-diabetes-without-clinical-diabetic-retinopathy
#1
Dan Cao, Dawei Yang, Zhongning Huang, Yunkao Zeng, Jun Wang, Yunyan Hu, Liang Zhang
AIMS: To investigate changes in retinal vascular plexuses and choriocapillaris in patients with type 2 diabetes mellitus (DM2) without diabetic retinopathy (DR) and healthy controls using optical coherence tomography angiography (OCTA). METHODS: A total of 71 DM2 and 67 healthy control subjects were included. All subjects underwent OCTA examination (RTVue-XR Avanti; Optovue, Fremont, CA, USA). Average vessel density in superficial capillary plexus (SCP), deep capillary plexus (DCP) and choriocapillaris, parafoveal vessel density in SCP and DCP, FAZ area (mm 2 ) in SCP, microaneurysms and capillary nonperfusion were taken into analysis...
February 16, 2018: Acta Diabetologica
https://www.readbyqxmd.com/read/29453109/genetic-basis-of-diabetic-kidney-disease-and-other-diabetic-complications
#2
REVIEW
Niina Sandholm, Per-Henrik Groop
Diabetic kidney disease and other long-term complications are common in diabetes, and comprise the main cause of co-morbidity and premature mortality in individuals with diabetes. While familial clustering and heritability have been reported for all diabetic complications, the genetic background and the molecular mechanisms remain poorly understood. In recent years, genome-wide association studies have identified a few susceptibility loci for the renal complications as well as for diabetic retinopathy, diabetic cardiovascular disease and mortality...
February 13, 2018: Current Opinion in Genetics & Development
https://www.readbyqxmd.com/read/29452885/somatolactogens-and-diabetic-retinopathy
#3
REVIEW
Kevin Christian Bermea, Alejandro Rodríguez-García, Andrew Tsin, Hugo Alberto Barrera-Saldaña
IMPORTANCE: Diabetic retinopathy (DR) is one of the most common of all diabetic complications. The number of people with DR in the United States is expected to increase to 16 million by 2050. DR is the leading cause of blindness among working-age adults in many different countries, including the United States. In later DR stages, neovascularization is associated with extensive retinal capillary non-perfusion and vitreo-proliferation leading to retinal detachment. This neovascularization is orchestrated by an imbalance of growth factors in the retina from which somatolactogens (pituitary growth hormone, GH-N; placental growth hormone, GH-V; prolactin, PRL; and placental lactogen, PL, also referred as chorionic somatomammotropin, CSH), may play an important role...
February 6, 2018: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/29452785/the-risks-of-sarcopenia-falls-and-fractures-in-patients-with-type-2-diabetes-mellitus
#4
REVIEW
C Sarodnik, S P G Bours, N C Schaper, J P van den Bergh, T A C M van Geel
Fracture risk in patients with type 2 diabetes mellitus (T2DM) is increased, and the mechanism is multifactorial. Recent research on T2DM-induced bone fragility shows that bone mineral density (BMD) is often normal or even slightly elevated. However, bone turnover may be decreased and bone material and microstructural properties are altered, especially when microvascular complications are present. Besides bone fragility, extra-skeletal factors leading to an increased propensity to experience falls may also contribute to the increased fracture risk in T2DM, such as peripheral neuropathy, retinopathy and diabetes medication (e...
March 2018: Maturitas
https://www.readbyqxmd.com/read/29451995/sex-dependent-choroidal-thickness-differences-in-healthy-adults-a-study-based-on-original-and-synthesized-data
#5
Wei Wang, Miao He, Xingwu Zhong
PURPOSE: The purpose of this study is to determine the influence of sex on choroidal thickness (CT) in healthy adults. METHODS: Healthy Chinese adults were recruited and complete ophthalmic examinations were performed. The choroid was imaged by swept-source optical coherence tomography and the macular CT in Early Treatment Diabetic Retinopathy Study grids was obtained by the intrinsic automated segmentation software. CT in males and females was compared after controlling other factors...
February 16, 2018: Current Eye Research
https://www.readbyqxmd.com/read/29451661/association-between-the-rage-receptor-for-advanced-glycation-end-products-374t-a-gene-polymorphism-and-diabetic-retinopathy-in-t2dm
#6
Dan Tao, Xuancheng Mai, Tiesong Zhang, Yan Mei
OBJECTIVE: Interaction between advanced glycation end-products (AGEs) and receptor for AGEs (RAGE) in cells could affect both extracellular and intracellular structure and function, which plays a pivotal role in diabetic microvascular complications. The results from previous epidemiological studies on the association between RAGE gene -374T/A polymorphism and diabetic retinopathy (DR) risk were inconsistent. Thus, we conducted this meta-analysis to summarize the possible association between RAGE -374T/A polymorphism and DR risk...
November 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/29450537/enhanced-expression-of-nlrp3-inflammasome-related-inflammation-in-diabetic-retinopathy
#7
Hui Chen, Xiongze Zhang, Nanying Liao, Lan Mi, Yuting Peng, Bing Liu, Shaochong Zhang, Feng Wen
Purpose: The aim of this study was to determine the association between nucleotide-binding and oligomerization domain (NOD)-like receptors (NLRs) family, pyrin domain-containing 3 (NLRP3) inflammasome-induced inflammation and disease severity in diabetic retinopathy (DR). Methods: Blood samples were collected from 64 patients with diabetes (DR, 43; without DR, 21) and 25 healthy controls. The protein and mRNA expression levels of NLRP3 inflammasomes in peripheral blood mononuclear cells were determined using western blotting and quantitative real-time reverse transcription-PCR...
February 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29450491/vision-related-functional-burden-of-diabetic-retinopathy-across-severity-levels-in-the-united-states-reply
#8
Jeffrey R Willis, Quan V Doan, Ronald A Cantrell
No abstract text is available yet for this article.
February 15, 2018: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29450482/potential-confounders-in-an-investigation-of-the-vision-related-functional-burden-of-diabetic-retinopathy
#9
Rui Feng, Prasanthi Sivakumaran
No abstract text is available yet for this article.
February 15, 2018: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29449951/glucagon-like-peptide-1-receptor-agonists-are-not-associated-with-retinal-adverse-events-in-the-fda-adverse-event-reporting-system
#10
Gian Paolo Fadini, Mayur Sarangdhar, Angelo Avogaro
Objectives: Glucagon-like peptide-1 receptor agonists (GLP-1RA) are widely used for the treatment of type 2 diabetes. In large trials, the GLP-1RAs liraglutide and semaglutide improved cardiovascular outcomes, but semaglutide was associated with an increased risk of retinopathy progression. We herein evaluated the association between GLP-1RA and retinal adverse events (AE) in the Food and Drug Administration Adverse Event Reporting System (FAERS). Research design and methods: We mined the FAERS between 2004q1 and 2017q1 (for a total of 9 217 555 AE reports) to analyze disproportionality and evaluate the association between GLP-1RAs and AEs involving the retina...
2018: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/29448286/-mitochondrial-dysfunctions-and-role-of-coenzyme-q10-in-patients-with-glaucoma
#11
Carl Erb, Katarzyna Konieczka
Mitochondrial function is closely linked to numerous aspects of eye health. Imbalance between the creation of energy and the development of reactive oxygen species (ROS) seems to be the cause of the development of mitochondrial dysfunctions. As a result of this energy deficit, the level of oxidative stress in the eye tissues increases, leading to numerous ophthalmic impairments. It is important to distinguish between primary mitochondrial eye diseases and secondary mitochondrial changes. Primary mitochondrial eye diseases, for example Leber's hereditary optic atrophy (LHON), retinitis pigmentosa and chronic progressive external ophthalmoplegia are caused by direct damage to mitochondrial function induced by defective genes, either located on mitochondrial DNA (mtDNA) or the DNA of the nucleus (nDNA)...
February 2018: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/29447914/progression-of-primary-open-angle-glaucoma-in-diabetic-and-non-diabetic-patients
#12
Huiyuan Hou, Takuhei Shoji, Linda M Zangwill, Sasan Moghimi, Luke J Saunders, Kyle Hasenstab, Elham Ghahari, Patricia Isabel C Manalastas, Tadamichi Akagi, Mark Christopher, Rafaella C Penteado, Robert N Weinreb
PURPOSE: To compare the rates of visual field (VF) loss and retinal nerve fiber layer (RNFL) thinning in primary open angle glaucoma (POAG) patients with or without type 2 diabetes mellitus (DM). DESIGN: Cohort study. METHODS: A total of 197 eyes (55 eyes of 32 POAG patients with DM in POAG/DM group and 142 eyes of 111 age-matched POAG patients without DM in POAG/DM- group) were included from the Diagnostic Innovations in Glaucoma Study (DIGS)...
February 12, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29445713/effects-of-laser-physical-parameters-on-lesion-size-in-retinal-photocoagulation-surgery-clinical-oct-and-experimental-study
#13
A Soleimani, S H Rasta, T Banaei, A Asgharsharghi Bonab
Introduction: The aim of the present study was to determine burn intensity in retinal laser photocoagulation based on laser parameters; wavelength, power, beam size and pulse duration, using Optical Coherence Tomography (OCT), fundus camera, physical eye model and computer simulation in a clinical study. Materials and Methods: Participants were 10 adult patients between 50-80 years with proliferative diabetic retinopathy. A multicolor-photo coagulator with 532 nm green and 672 nm red for retina photocoagulation in diabetic retinopathy was used to investigate the participants...
December 2017: Journal of Biomedical Physics & Engineering
https://www.readbyqxmd.com/read/29445357/gender-difference-in-the-association-of-early-vs-late-onset-type-2-diabetes-with-non-fatal-microvascular-disease-in-china-a-cross-sectional-study
#14
Xiaoxu Huo, Junqing Zhang, Xiaohui Guo, Juming Lu, Jing Li, Wei Zhao, Linong Ji, Xilin Yang
Background: This study aimed to test whether early-onset (defined as <40 years of age) type 2 diabetes mellitus (T2DM) imparted different risks of microvascular disease to Chinese men and women. Methods: 222,537 Chinese patients with T2DM were recruited in 630 hospitals from 106 cities in 30 provinces of China in 2012 using a cross-sectional design. Logistic regression analysis was performed to obtain odds ratios (ORs) of male vs. female for diabetic retinopathy (DR) and diabetic nephropathy (DN)...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29445185/iron-overload-accelerates-the-progression-of-diabetic-retinopathy-in-association-with-increased-retinal-renin-expression
#15
Kapil Chaudhary, Wanwisa Promsote, Sudha Ananth, Rajalakshmi Veeranan-Karmegam, Amany Tawfik, Pachiappan Arjunan, Pamela Martin, Sylvia B Smith, Muthusamy Thangaraju, Oleg Kisselev, Vadivel Ganapathy, Jaya P Gnana-Prakasam
Diabetic retinopathy (DR) is a leading cause of blindness among working-age adults. Increased iron accumulation is associated with several degenerative diseases. However, there are no reports on the status of retinal iron or its implications in the pathogenesis of DR. In the present study, we found that retinas of type-1 and type-2 mouse models of diabetes have increased iron accumulation compared to non-diabetic retinas. We found similar iron accumulation in postmortem retinal samples from human diabetic patients...
February 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29444552/optometry-facilitated-teleophthalmology-an-audit-of-the-first-year-in-western-australia
#16
Stephen E Bartnik, Stephen P Copeland, Angela J Aicken, Angus W Turner
BACKGROUND: Lions Outback Vision has run a state-wide teleophthalmology service since 2011. In September 2015 the Australian federal government introduced a Medicare reimbursement for optometry-facilitated teleophthalmology consultations under specific circumstances. This audit demonstrates the first 12 months experience with this scheme. We aim to provide practical insights for others looking to embed a telemedicine program as part of delivering outreach clinical services. METHODS: A 12-month retrospective audit was performed between September 2015 and August 2016, inclusive...
February 14, 2018: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/29442454/higher-concentrations-of-osteoprotegerin-in-type-1-diabetic-patients-are-related-to-retinopathy-results-from-the-pozna%C3%A5-prospective-study
#17
Agata Grzelka, Dariusz Naskręt, Aleksandra Araszkiewicz, Aleksandra Uruska, Małgorzata Wegner, Dorota Zozulińska-Ziółkiewicz
BACKGROUND: Osteoprotegerin (OPG) is an arterial calcification marker which has been associated with vascular damage. Elevated OPG concentrations associated with low-grade inflammatory processes are found in diabetic subjects. OBJECTIVES: The aim of the study was to assess concentrations of OPG in relation to the presence of diabetic complications in patients with diabetes type 1 (DM 1) participating in the Poznań Prospective Study (PoProStu). MATERIAL AND METHODS: The study included 74 patients with DM1 (48 men) with a median age of 39 years (interquartile range [IQR]: 34-43) and a median 15-year history (IQR: 14-16) of diabetes, who were participants in the PoProStu...
December 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29439828/consistent-long-term-therapy-of-neovascular-age-related-macular-degeneration-managed-by-50-or-more-anti-vegf-injections-using-a-treat-extend-stop-protocol
#18
Sean D Adrean, Siyang Chaili, Hema Ramkumar, Ash Pirouz, Scott Grant
PURPOSE: To examine the clinical results for patients with neovascular age-related macular degeneration (nAMD) who were managed with a treat-extend-stop (TES) protocol and received 50 or more injections of anti-vascular endothelial growth factor (VEGF) agents. DESIGN: Retrospective case study. PARTICIPANTS: Data for patients from a private retina practice meeting the following criteria were included: diagnosis of nAMD and having received 50 or more intravitreal injections of anti-VEGF agents...
February 10, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29439603/semaglutide-in-type-2-diabetes-is-it-the-best-glucagon-like-peptide-1-receptor-agonist-glp-1r-agonist
#19
Sheila A Doggrell
Glucagon-like peptide-1 (GLP-1) is produced by the gut, and in a glucose-dependent manner stimulates insulin secretion while inhibiting glucagon secretion, reduces appetite and energy intake, and delays gastric emptying. The GLP-1R agonist semaglutide has recently been registered for use in the treatment of type 2 diabetes. Area covered: This review is of semaglutide in type 2 diabetes, and considers which properties of this GLP-1R agonist, may be responsible for its clinical outcome benefits in this condition...
February 13, 2018: Expert Opinion on Drug Metabolism & Toxicology
https://www.readbyqxmd.com/read/29439274/relation-of-paraoxonase-1-activity-with-biochemical-variables-brachial-artery-intima-media-thickness-in-patients-with-diabetes-with-or-without-obesity
#20
Pinar Karakaya, Bahar Ozdemir, Meral Mert, Yildiz Okuturlar
AIM: The sodium-sparing effect of insulin leads to increase in total sodium pool of the body which is a chronic stimulus for atrial natriuretic peptide (ANP). In our study we aimed to determine the relationship between ANP and microvascular complications of diabetes. METHODS: 60 patients, 30-70 years old, with the diagnosis of type 2 diabetes mellitus (DM) are enrolled into the study. Patients with a chronic disease other than DM are excluded. Blood samples for routine biochemical tests are taken after at least 12 h fasting at 8-9 am...
February 14, 2018: Obesity Facts
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