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Diabetes,diabetic retinopathy

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https://www.readbyqxmd.com/read/29909237/glycosylation-as-new-pharmacological-strategies-for-diseases-associated-with-excessive-angiogenesis
#1
REVIEW
Simon Bousseau, Luisa Vergori, Raffaella Soleti, Guy Lenaers, M Carmen Martinez, Ramaroson Andriantsitohaina
Angiogenesis is a complex process describing the growth of new blood vessels from existing vasculature, and is triggered by local pro-angiogenic factors, such as vascular endothelial growth factor (VEGF), which increase the metabolism of endothelial cells (ECs). Angiogenesis takes part in various physiological conditions such as embryogenesis, placental growth, and in pathological conditions such as tumor growth, diabetic retinopathy, rheumatoid arthritis (RA) and ischemic diseases. Current therapies against excessive angiogenesis target vascular growth signaling...
June 14, 2018: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29907582/social-network-characteristics-are-associated-with-type-2-diabetes-complications-the-maastricht-study
#2
Stephanie Brinkhues, Nicole H T M Dukers-Muijrers, Christian J P A Hoebe, Carla J H van der Kallen, Annemarie Koster, Ronald M A Henry, Coen D A Stehouwer, Paul H M Savelkoul, Nicolaas C Schaper, Miranda T Schram
OBJECTIVE: The relation between clinical complications and social network characteristics in type 2 diabetes mellitus (T2DM) has hardly been studied. Therefore, we examined the associations of social network characteristics with macro- and microvascular complications in T2DM and investigated whether these associations were independent of glycemic control, quality of life, and well-known cardiovascular risk factors. RESEARCH DESIGN AND METHODS: Participants with T2DM originated from the Maastricht Study, a population-based cohort study ( n = 797, mean age 62...
June 15, 2018: Diabetes Care
https://www.readbyqxmd.com/read/29907545/differential-proteome-analysis-of-diabetes-mellitus-type-2-and-its-pathophysiological-complications
#3
REVIEW
Waleed Sohail, Fatimah Majeed, Amber Afroz
The prevalence of Diabetes Mellitus Type 2 (DM 2) is increasing every passing year due to some global changes in lifestyles of people. The exact underlying mechanisms of the progression of this disease are not yet known. However recent advances in the combined omics more particularly in proteomics and genomics have opened a gateway towards the understanding of predetermined genetic factors, progression, complications and treatment of this disease. Here we shall review the recent advances in proteomics that have led to an early and better diagnostic approaches in controlling DM 2 more importantly the comparison of structural and functional protein biomarkers that are modified in the diseased state...
June 11, 2018: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29904118/psoriasis-risk-in-patients-with-diabetic-retinopathy-a-nationwide-population-based-study
#4
Ji Hyun Lee, Ju Hee Han, Kyung Do Han, Young Min Park, Jun Young Lee, Yong-Gyu Park, Young Bok Lee
Psoriasis is a chronic cutaneous disease known to be related with systemic disease; however, the association between psoriasis and diabetic complications has not been previously reported. Diabetic microvascular complications include diabetic retinopathy (DR), nephropathy, and neuropathy, and overt diabetic nephropathy can lead to the end-stage renal disease (ESRD).The present study investigated the association between psoriasis and non-proliferative DR (NPDR) or proliferative DR (PDR) or ESRD. We analyzed the relationship between diabetic complication and psoriasis using data from the National Health Insurance Service between 2009 and 2015...
June 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29903774/unilateral-retinopathy-in-a-patient-with-diabetes-and-coronary-heart-disease
#5
Maria Fernanda Abalem, Kim A Eagle, Rajesh C Rao
No abstract text is available yet for this article.
June 14, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29903480/a-mobile-computer-aided-system-for-optic-nerve-head-detection
#6
Yaroub Elloumi, Mohamed Akil, Nasser Kehtarnavaz
BACKGROUND AND OBJECTIVE: The detection of optic nerve head (ONH) in retinal fundus images plays a key role in identifying Diabetic Retinopathy (DR) as well as other abnormal conditions in eye examinations. This paper presents a method and its associated software towards the development of an Android smartphone app based on a previously developed ONH detection algorithm. The development of this app and the use of the d-Eye lens which can be snapped onto a smartphone provide a mobile and cost-effective computer-aided diagnosis (CAD) system in ophthalmology...
August 2018: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/29903039/adapting-clinical-practice-guidelines-for-diabetic-retinopathy-in-kenya-process-and-outputs
#7
Nyawira Mwangi, Muchai Gachago, Michael Gichangi, Stephen Gichuhi, Kibata Githeko, Atieno Jalango, Jefitha Karimurio, Joseph Kibachio, Lawrence Muthami, Nancy Ngugi, Carmichael Nduri, Patrick Nyaga, Joseph Nyamori, Alain Nazaire Mbongo Zindamoyen, Covadonga Bascaran, Allen Foster
BACKGROUND: The use of clinical practice guidelines envisages augmenting quality and best practice in clinical outcomes. Generic guidelines that are not adapted for local use often fail to produce these outcomes. Adaptation is a systematic and rigorous process that should maintain the quality and validity of the guideline, while making it more usable by the targeted users. Diverse skills are required for the task of adaptation. Although adapting a guideline is not a guarantee that it will be implemented, adaptation may improve acceptance and adherence to its recommendations...
June 15, 2018: Implementation Science: IS
https://www.readbyqxmd.com/read/29902297/automated-quantification-of-nonperfusion-areas-in-3-vascular-plexuses-with-optical-coherence-tomography-angiography-in-eyes-of-patients-with-diabetes
#8
Thomas S Hwang, Ahmed M Hagag, Jie Wang, Miao Zhang, Andrew Smith, David J Wilson, David Huang, Yali Jia
Importance: Diabetic retinopathy (DR) is a leading cause of vision loss that is managed primarily through qualitative clinical examination of the retina. Optical coherence tomography angiography (OCTA) may offer an objective and quantitative method of evaluating DR. Objective: To quantify capillary nonperfusion in 3 vascular plexuses in the macula of eyes patients with diabetes of various retinopathy severity using projection-resolved OCTA (PR-OCTA). Design, Setting, and Participants: Cross-sectional study at a tertiary academic center comprising 1 eye each from healthy control individuals and patients with diabetes at different severity stages of retinopathy...
June 14, 2018: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29901495/evaluation-of-multispectral-imaging-in-diagnosing-diabetic-retinopathy
#9
Liang Li, Pu Zhang, Hong Liu, Yu-Hua Liu, Ling Gao
PURPOSE: To investigate multispectral imaging (MSI) as a novel diagnostic approach for diabetic retinopathy (DR) in clinic. METHODS: A total of 50 Type-2 diabetic patients (99 eyes) were enrolled in this cross-sectional study. All subjects underwent digital fundus photography (DFP), MSI, and fundus fluorescein angiography. A total exact agreement, sensitivity, specificity, positive predictive value, and negative predictive value of no DR/mild nonproliferative diabetic retinopathy (NPDR) and severe NPDR/proliferative diabetic retinopathy (PDR) grading were calculated based on DFP and MSI and were compared with fundus fluorescein angiography...
June 12, 2018: Retina
https://www.readbyqxmd.com/read/29900203/manually-segmented-vascular-networks-from-images-of-retina-with-proliferative-diabetic-and-hypertensive-retinopathy
#10
Natasa Popovic, Miroslav Radunovic, Jelena Badnjar, Tomo Popovic
In this article we present a data set that contains 37 image files obtained by manual vessel segmentation of raw retinal images from Structured Analysis of the Retina (STARE) database ("The STARE Project", 2018) [1]. Our expert segmented 8 images that are associated with the single diagnosis of hypertensive retinopathy and 9 images with the single diagnosis of proliferative diabetic retinopathy (Popovic et al., 2018) [2]. To validate the manual segmentation, the same expert additionally segmented a gold standard set of 20 raw images from the STARE database...
June 2018: Data in Brief
https://www.readbyqxmd.com/read/29899983/prevalence-risk-factors-and-burden-of-diabetic-retinopathy-in-china-a-systematic-review-and-meta-analysis
#11
Peige Song, Jinyue Yu, Kit Yee Chan, Evropi Theodoratou, Igor Rudan
Background: Diabetic retinopathy (DR), the primary retinal vascular complication of diabetes mellitus (DM), is a leading cause of vision impairment and blindness in working-age population globally. Despite mounting concerns about the emergence of DM as a major public health problem in the largest developing country, China, much remains to be understood about the epidemiology of DR. We aimed to investigate the prevalence of and risk factors for DR, and estimate the burden of DR in China in 2010...
June 2018: Journal of Global Health
https://www.readbyqxmd.com/read/29899647/causes-of-permanent-severe-visual-impairment-and-blindness-among-jordanian-population
#12
Basel Turki Baarah, Raed Ali Shatnawi, Ahmed Essa Khatatbeh
PURPOSE: To report the causes of permanent severe visual impairment and blindness among Jordanian blind people. MATERIALS AND METHODS: This study was conducted on 1422 legally blind or worse vision people of all ages who attended the ophthalmic division of a medical committee for evaluation of disabled persons from July 2013 through November 2014. They were divided into two age groups: adult group (998 cases) and childhood group (<16 years, 424 cases). Patients presented reports from their ophthalmologists detailing their eye examination including best-corrected visual acuity, slit-lamp examinations, and if applicable, intraocular pressure, dilated ophthalmoscopy, and visual field and the primary cause of visual impairment...
January 2018: Middle East African Journal of Ophthalmology
https://www.readbyqxmd.com/read/29897081/a-non-invasive-nanoparticle-mediated-delivery-of-triamcinolone-acetonide-ameliorates-diabetic-retinopathy-in-rats
#13
Binapani Mahaling, Dadi A Srinivasarao, G Raghu, Rajesh K Kasam, G Bhanuprakash Reddy, Dhirendra S Katti
Diabetic retinopathy (DR) is a multifactorial manifestation associated with microvascular complications and is the fourth leading cause of visual impairment and blindness world-wide. Current day treatment of DR relies heavily on invasive techniques such as intravitreal injections of therapeutic agents. Unfortunately, intravitreal injections are associated with various complications such as intraocular bleeding, endophthalmitis, pain and discomfort resulting in poor patient compliance. To date, there has been no non-invasive drug delivery system reported for DR treatment...
June 13, 2018: Nanoscale
https://www.readbyqxmd.com/read/29896720/stem-cell-therapy-and-type-1-diabetes-mellitus-treatment-strategies-and-future-perspectives
#14
Tahir Farooq, Kanwal Rehman, Arruje Hameed, Muhammad Sajid Hamid Akash
Type 1 diabetes mellitus (T1DM) is classified as an autoimmune disease which progressively results in the depletion of insulin-secreting β-cells. Consequently, the insulin secretion stops leading to hyperglycemic situations within the body. Under severe conditions, it also causes multi-organ diabetes-associated dysfunctionalities notably hypercoagulability, neuropathy, nephropathy, retinopathy, and sometimes organ failures. The prevalence of this disease has been noticed about 3% that has highlighted the serious concerns for healthcare professionals around the globe...
June 13, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29896271/microrna-27a-protects-retinal-pigment-epithelial-cells-under-high-glucose-conditions-by-targeting-tlr4
#15
Xiaolei Tang, Yan Dai, Xiaoli Wang, Jian Zeng, Guirong Li
The present study aimed to investigate whether microRNA-27a (miRNA27a) is associated with the pathogenesis of diabetic retinopathy, and to elucidate the underlying molecular mechanism of any potential association. In retinal pigment epithelial (RPE) cells treated with high glucose, miRNA27a expression, determined by reverse transcription-quantitative polymerase chain reaction analysis, was decreased. Caspase-3/9 activity and B-cell lymphoma 2-associated X (Bax) protein expression was increased in RPE cells subjected to high glucose...
July 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29896254/molecular-mechanism-of-the-role-of-carbamyl-erythropoietin-in-treating-diabetic-retinopathy-rats
#16
Xuegu Xu, Yonghao Cai, Yinfei Yu
The aim of the present study was to investigate the therapeutic effects of carbamyl erythropoietin (CEPO) and safflor yellow (SY) in the treatment of rats with diabetic retinopathy (DR) as well as exploring the mechanism of action. Male SD rats were used to establish a diabetes model and streptozotocin-induced retinopathy was also performed in rats. A total of 126 rats with DR were obtained, and model rats were randomly divided into the model (n=42), experimental (n=42) and control (n=42) groups. The rats in the model group were injected with saline, the rats in the experimental group were treated with CEPO, and the rats in the control group were treated with SY...
July 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29896154/basis-and-design-of-a-randomized-clinical-trial-to-evaluate-the-effect-of-levosulpiride-on-retinal-alterations-in-patients-with-diabetic-retinopathy-and-diabetic-macular-edema
#17
Ma Ludivina Robles-Osorio, Renata García-Franco, Carlos D Núñez-Amaro, Ximena Mira-Lorenzo, Paulina Ramírez-Neria, Wendy Hernández, Ellery López-Star, Thomas Bertsch, Gonzalo Martínez de la Escalera, Jakob Triebel, Carmen Clapp
Background: Diabetic retinopathy (DR) and diabetic macular edema (DME) are potentially blinding, microvascular retinal diseases in people with diabetes mellitus. Preclinical studies support a protective role of the hormone prolactin (PRL) due to its ocular incorporation and conversion to vasoinhibins, a family of PRL fragments that inhibit ischemia-induced retinal angiogenesis and diabetes-derived retinal vasopermeability. Here, we describe the protocol of an ongoing clinical trial investigating a new therapy for DR and DME based on elevating the circulating levels of PRL with the prokinetic, dopamine D2 receptor blocker, levosulpiride...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29895120/-analysis-on-the-trend-of-innovation-and-development-in-the-field-of-ophthalmology
#18
L H Shan, X Y An, M M Xu, S P Fan, H Zhong, P Ni, H Chi
Objective: To systematically analyze the innovation and development trend in the field of ophthalmology. Methods: The latest ophthalmology funding program from the National Eye Institute and National Natural Science Foundation of China, and funding project for 2012 to 2016 from the National Institutes of Health, National Natural Science Foundation of China and National key research and development plan of China was collected. Using the comparative analysis method, the major ophthalmology funding areas at home and abroad were analyzed...
June 11, 2018: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29893142/microangiopathy-is-associated-with-bone-loss-in-female-type-2-diabetes-mellitus-patients
#19
Ni Zhong, Youyang Zhang, Xiangling Pu, Bei Xu, Mingxin Xu, Haidong Cai, Ge Zhang, Ran Cui, Hui Sheng, Shen Qu
OBJECTIVE: Type 2 diabetes mellitus complicated with microvascular diseases can be used as a model to study the relationship between bone health and the microvascular situation. METHODS: A total of 2,170 patients with type 2 diabetes mellitus (1,188 postmenopausal females and 982 males aged ⩾50 years) were included in our cross-sectional study. These patients were grouped according to 24-hour urine protein level: Group I (<30 mg), Group II (30-299 mg) and Group III (≥300 mg)...
June 1, 2018: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/29892340/declining-trends-of-diabetic-nephropathy-retinopathy-and-neuropathy-with-improving-diabetes-care-indicators-in-japanese-patients-with-type-2-and-type-1-diabetes-jddm-46
#20
Hiroki Yokoyama, Shin-Ichi Araki, Koichi Kawai, Katsuya Yamazaki, Osamu Tomonaga, Shin-Ichiro Shirabe, Hiroshi Maegawa
Objective: We examined changes in prevalence of diabetic microvascular/macrovascular complications and diabetes care indicators for adults in Japan with type 2 and type 1 diabetes over one decade. Research design and methods: Two independent cohorts were recruited with the same inclusion criteria in 2004 (cohort 1: 3319 with type 2 and 286 with type 1 diabetes) and in 2014 (cohort 2: 3932 with type 2 and 308 with type 1 diabetes). Prevalence of complications and care indicators including achieving treatment targets for glycemia, blood pressure, lipid control, body mass index (BMI), and smoking were compared...
2018: BMJ Open Diabetes Research & Care
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