keyword
https://read.qxmd.com/read/38536516/the-role-of-oxidative-stress-in-the-pathogenesis-of-ocular-diseases-an-overview
#1
REVIEW
Miao Zhang, Ruixue Zhang, Xiaoyue Zhao, Zhongyu Ma, Jizhao Xin, Shuqin Xu, Dadong Guo
Dysregulation of oxidative stress serves as a pivotal predisposing or exacerbating factor in the intricate development of numerous pathological processes and diseases. In recent years, substantial evidence has illuminated the crucial role of reactive oxygen species (ROS) in many fundamental cellular functions, including proliferation, inflammation, apoptosis, and gene expression. Notably, producing free radicals within ROS profoundly impacts a wide range of biomolecules, such as proteins and DNA, instigating cellular damage and impairing vital cellular functions...
March 27, 2024: Molecular Biology Reports
https://read.qxmd.com/read/38536234/target-product-profile-for-a-machine-learning-automated-retinal-imaging-analysis-software-for-use-in-english-diabetic-eye-screening-protocol-for-a-mixed-methods-study
#2
JOURNAL ARTICLE
Trystan Macdonald, Jacqueline Dinnes, Gregory Maniatopoulos, Sian Taylor-Phillips, Bethany Shinkins, Jeffry Hogg, John Kevin Dunbar, Ameenat Lola Solebo, Hannah Sutton, John Attwood, Michael Pogose, Rosalind Given-Wilson, Felix Greaves, Carl Macrae, Russell Pearson, Daniel Bamford, Adnan Tufail, Xiaoxuan Liu, Alastair K Denniston
BACKGROUND: Diabetic eye screening (DES) represents a significant opportunity for the application of machine learning (ML) technologies, which may improve clinical and service outcomes. However, successful integration of ML into DES requires careful product development, evaluation, and implementation. Target product profiles (TPPs) summarize the requirements necessary for successful implementation so these can guide product development and evaluation. OBJECTIVE: This study aims to produce a TPP for an ML-automated retinal imaging analysis software (ML-ARIAS) system for use in DES in England...
March 27, 2024: JMIR Research Protocols
https://read.qxmd.com/read/38534040/characterization-of-the-visually-impaired-patients-with-diabetes-mellitus-in-japan
#3
JOURNAL ARTICLE
Yuka Sugihara, Yoshihiro Takamura, Yutaka Yamada, Masakazu Morioka, Makoto Gozawa, Kumiko Kato, Takao Hirano, Fumiko Murao, Miho Shimizu, Sentaro Kusuhara, Tomoya Murakami, Yuki Takenaka, Naoko Okabe, Tatsuya Jujo, Hiroto Terasaki, Daisuke Nagasato, Zhenyu Dong, Shigeo Yoshida, Shuntaro Ogura, Kanako Yasuda, Gaku Ishigooka, Osamu Sawada, Fumiaki Higashijima, Masaru Inatani
AIMS/INTRODUCTION: To conduct a multicenter survey of visually impaired patients with diabetes mellitus (DM) and to identify the physical and ocular characteristics that lead to blindness in Japan. MATERIALS AND METHODS: Visually impaired patients with diabetes mellitus in Japan were divided into blind and low-vision groups according to the World Health Organization classification. Data on parameters related to diabetes mellitus and ocular complications in the right and left eyes were collected from 19 highly advanced medical facilities and compared between the two groups...
March 27, 2024: Journal of Diabetes Investigation
https://read.qxmd.com/read/38533289/screening-of-individuals-with-type-2-diabetes-on-anti-diabetic-agents-for-probable-hypoglycaemia-using-the-stanford-hypoglycemia-questionnaire-shq-in-outpatient-settings-a-cross-sectional-study-from-outpatient-diabetes-care-centres-in-north-india
#4
JOURNAL ARTICLE
Rajiv Awasthi, Arun K Pande, Kumar P Chandra, Vivek Agarwal, Mukulesh Gupta, Ajoy Tewari, Nitin Gupta, Santosh Chaubey, Sandeep Chaudhary, Sajid Ansari, Dinesh Kumar
INTRODUCTION: The study was aimed at identifying the incidence of unreported probable hypoglycaemia in individuals with type 2 diabetes (T2DM) on anti-diabetic medications, using the screening Stanford Hypoglycemia Questionnaire (SHQ) in real-world situations. METHODS: It was a multicentre cross-sectional study on consecutive individuals attending 10 diabetes care centres in Lucknow, Uttar Pradesh, India. The inclusion criteria were as follows: known individuals with T2DM, literate, age greater than or equal to 18 years, on at least one anti-diabetic agent for more than a month and not engaged in regular self-monitoring of blood glucose (SMBG)...
2024: Indian Journal of Endocrinology and Metabolism
https://read.qxmd.com/read/38533176/serum-and-vitreous-levels-of-placenta-growth-factor-in-diabetic-retinopathy-patients-correlation-with-disease-severity-and-optical-coherence-tomographic-parameters
#5
JOURNAL ARTICLE
Joana Mesquita, Fátima Milhano Santos, João Paulo Sousa, Sara Vaz-Pereira, Paulo Tavares-Ratado, Arminda Neves, Rita Mesquita, Cândida Teixeira Tomaz
Purpose The primary objective of this study was to compare placenta growth factor (PlGF) levels in the serum and vitreous of diabetic retinopathy (DR) patients to non-diabetic controls. Additionally, the study aimed to establish associations between serum and vitreous PlGF concentrations and to examine the correlation between vitreous PlGF in DR patients and morphological parameters. Methods This study included serum and vitreous samples from 38 patients, including 21 patients with DR and 17 non-diabetic controls...
February 2024: Curēus
https://read.qxmd.com/read/38533089/novel-lipid-mediator-7-s-14-r-docosahexaenoic-acid-biogenesis-and-harnessing-mesenchymal-stem-cells-to-ameliorate-diabetic-mellitus-and-retinal-pericyte-loss
#6
JOURNAL ARTICLE
Yan Lu, Haibin Tian, Hongying Peng, Quansheng Wang, Bruce A Bunnell, Nicolas G Bazan, Song Hong
Introduction: Stem cells can be used to treat diabetic mellitus and complications. ω3-docosahexaenoic acid (DHA) derived lipid mediators are inflammation-resolving and protective. This study found novel DHA-derived 7 S ,14 R -dihydroxy-4 Z ,8 E ,10 Z ,12 E ,16 Z ,19 Z -docosahexaenoic acid (7 S ,14 R -diHDHA), a maresin-1 stereoisomer biosynthesized by leukocytes and related enzymes. Moreover, 7 S ,14 R -diHDHA can enhance mesenchymal stem cell (MSC) functions in the amelioration of diabetic mellitus and retinal pericyte loss in diabetic db/db mice...
2024: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/38532241/gene-expression-analysis-in-t2dm-and-its-associated-microvascular-diabetic-complications-focus-on-risk-factor-and-raas-pathway
#7
JOURNAL ARTICLE
Laxmipriya Jena, Prabhsimran Kaur, Tashvinder Singh, Kangan Sharma, Sushil Kotru, Anjana Munshi
Prolonged hyperglycemic conditions in type 2 diabetes mellitus (T2DM) cause pathological and functional damage to many organs and tissues, including the kidneys, retina, skin, and neuronal tissues, resulting in the development of microvascular diabetic complications. The altered renin angiotensin aldosterone system (RAAS) pathway has been reported to play an important role in the development of insulin resistance in T2DM and associated complications. The current study was carried out to evaluate the association of risk factors and altered expression of RAAS genes in T2DM patients without complications and T2DM patients with complications (retinopathy, nephropathy, and neuropathy)...
March 27, 2024: Molecular Neurobiology
https://read.qxmd.com/read/38530988/investigating-the-utility-of-near-infrared-reflectance-imaging-for-diabetic-retinopathy-screening
#8
JOURNAL ARTICLE
Sachi A Patil, Samyuktha P Guttha, Archana A Nair, Saagar Pandit, Ravi Parikh, Ting-Fang Lee, Jiyuan Hu, Nitish Mehta, Yasha S Modi
BACKGROUND AND OBJECTIVE: We investigated the reliability of near-infrared reflectance (NIR) imaging as a method of assessing severity of diabetic retinopathy (DR). PATIENTS AND METHODS: One hundred ninety-five NIR images were reviewed by two graders for the number of hyporeflective foci, presence or absence of vascular abnormalities, and presumptive DR stage; these were correlated to fundus photography-defined DR stage. Interrater reliability was confirmed via one-way random effects model of intraclass correlation coefficients...
March 1, 2024: Ophthalmic Surgery, Lasers & Imaging Retina
https://read.qxmd.com/read/38530451/the-longitudinal-follow-up-of-a-newly-proposed-octa-imaging-finding-sspim-and-the-importance-of-it-as-a-new-biomarker-for-treatment-response-in-diabetic-macular-edema
#9
JOURNAL ARTICLE
Gülsüm Genç, Özge Yanık, Sibel Demirel, Figen Batioglu, Emin Özmert
PURPOSE: This study aimed to evaluate the frequency of SSPiM (suspended scattering particles in motion), systemic risk factors, ocular findings, progression characteristics, and treatment response in diabetic retinopathy (DR) patients. METHODS: In this prospective study, a total of 109 eyes of 109 patients with diabetic macular edema (DME) were included. Demographic characteristics and systemic data of the patients were recorded. In addition to a detailed ophthalmological examination, optical coherence tomography (OCT) and OCT angiography (OCTA) imaging were performed...
March 26, 2024: Graefe's Archive for Clinical and Experimental Ophthalmology
https://read.qxmd.com/read/38530415/the-association-of-islet-autoantibodies-with-the-neural-retinal-thickness-and-microcirculation-in-type-1-diabetes-mellitus-with-no-clinical-evidence-of-diabetic-retinopathy
#10
JOURNAL ARTICLE
Tong Wang, Tong Zhang, Ning Dong, Yao Tan, Xia Li, Yuting Xie, Liang Li, Yandan Zhou, Pu Zhang, Ming Li, Qianxin Li, Ruixuan Wang, Ronghan Wu, Ling Gao
OBJECTIVE: To examine the association between islet autoantibodies (IAbs) and the retinal neurovascular changes in type 1 diabetes mellitus (T1DM) with no diabetic retinopathy (NDR). METHODS: This cross-sectional study measured the neural retinal structure and microvascular density of 118 NDR eyes using spectral-domain optical coherence tomography angiography. Retinal structure parameters included retinal thickness (RT), inner retinal thickness (iRT), retina never fibral layer thickness (RNFL thickness), ganglion cell complex thickness (GCC thickness), and loss volume of GCC...
March 26, 2024: Acta Diabetologica
https://read.qxmd.com/read/38529001/exacerbation-of-diabetic-retinopathy-following-hypoxia-inducible-factor-prolyl-hydroxylase-inhibitor-administration-a-case-report
#11
Nobuaki Ariyoshi, Fumiaki Higashijima, Makiko Wakuta, Tadahiko Ogata, Manami Ohta, Kazuhiro Kimura
INTRODUCTION: Hypoxia-inducible factor-prolyl hydroxylase (HIF-PH) inhibitors, used in the treatment of renal anemia, hold the potential to increase the production of vascular endothelial growth factors. Therefore, HIF-PH inhibitors may exacerbate retinal hemorrhage in diseases such as diabetic retinopathy. Here, we present a case involving the administration of an HIF-PH inhibitor, resulting in the exacerbation of retinal hemorrhage in a patient with diabetic retinopathy. CASE PRESENTATION: A 32-year-old man with diabetes mellitus and renal anemia caused by diabetic nephropathy was referred to our department for ophthalmic examination, revealing diabetic retinopathy with scattered retinal hemorrhages, exudates, and diabetic maculopathy in both eyes...
2024: Case Reports in Ophthalmology
https://read.qxmd.com/read/38528638/correction-sight-threatening-diabetic-retinopathy-in-patients-with-macular-telangiectasia-type-2
#12
Josef Huemer, Tjebo Fc Heeren, Abraham Olvera-Barrios, Livia Faes, Antonio M B Casella, Edward Hughes, Adnan Tufail, Catherine Egan
No abstract text is available yet for this article.
March 25, 2024: International Journal of Retina and Vitreous
https://read.qxmd.com/read/38528132/prevalence-of-diabetic-kidney-disease-and-the-associated-factors-among-patients-with-type-2-diabetes-in-a-multi-ethnic-asian-country
#13
JOURNAL ARTICLE
Kim Sui Wan, Noran Naqiah Hairi, Feisul Mustapha, Muhammad Fadhli Mohd Yusoff, Halizah Mat Rifin, Mastura Ismail, Foong Ming Moy, Noor Ani Ahmad
The actual prevalence of diabetic kidney disease (DKD) in patients with type 2 diabetes (T2D) in Malaysia is unknown. We aimed to determine the prevalence of DKD and its associated risk factors among T2D patients in Malaysia. An analytical cross-sectional study was conducted using the year 2022 clinical audit dataset from the National Diabetes Registry. DKD was defined as albuminuria, a decreased glomerular filtration rate, or both. Among 80,360 patients, 62.2% were female, 68.4% were Malay, and the mean age was 61...
March 25, 2024: Scientific Reports
https://read.qxmd.com/read/38527858/the-retinal-oxygen-metabolism-and-hemodynamics-as-a-substitute-for-biochemical-tests-to-predict-nonproliferative-diabetic-retinopathy
#14
JOURNAL ARTICLE
Chuanqing Zhou, Zixia Zhou, Ximeng Feng, Da Zou, Yilin Zhou, Bin Zhang, Jiabao Chen, Fei Wang, Dingying Liao, Jinying Li, Zi Jin, Qiushi Ren
Predicting the occurrence of nonproliferative diabetic retinopathy (NPDR) using biochemical parameters is invasive, which limits large-scale clinical application. Noninvasive retinal oxygen metabolism and hemodynamics of 215 eyes from 73 age-matched healthy subjects, 90 diabetic patients without DR, 40 NPDR, and 12 DR with postpanretinal photocoagulation were measured with a custom-built multimodal retinal imaging device. Diabetic patients underwent biochemical examinations. Two logistic regression models were developed to predict NPDR using retinal and biochemical metrics, respectively...
March 25, 2024: Journal of Biophotonics
https://read.qxmd.com/read/38527395/relationship-of-microvascular-complications-and-healthy-lifestyle-with-all-cause-and-cardiovascular-mortality-in-women-compared-with-men-with-type-2-diabetes
#15
JOURNAL ARTICLE
Yu-Jie Liu, Fu-Rong Li, Wen-Wen Han, Yan Liu, Yu Liu, Jia-Min Wang, Meng-Yuan Miao, Jie-Qiong Lyu, Zhong-Xiao Wan, Li-Qiang Qin, Guo-Chong Chen
BACKGROUND: Sex differences exist in the prevalence of microvascular disease (MVD) and healthy-lifestyle adherence. Whether MVD and healthy lifestyles are associated with mortality risk similarly for women and men who have type 2 diabetes mellitus (T2DM) remains unknown. METHODS: The present study included 9992 women and 15,860 men with T2DM from the UK Biobank. MVDs included retinopathy, peripheral neuropathy, and chronic kidney disease. Healthy lifestyle factors consisted of ideal BMI, nonsmoking, healthy diet, regular exercise, and appropriate sleep duration...
March 20, 2024: Clinical Nutrition
https://read.qxmd.com/read/38526804/diabetic-disease-of-the-eye-in-canada-consensus-statements-from-a-retina-specialist-working-group
#16
JOURNAL ARTICLE
Amer Omar, R Geoff Williams, James Whelan, Jason Noble, Michael H Brent, Michel Giunta, Sébastien Olivier, Mustapha Lhor
Despite advances in systemic care, diabetic disease of the eye (DDE) remains the leading cause of blindness worldwide. There is a critical gap of up-to-date, evidence-based guidance for ophthalmologists in Canada that includes evidence from recent randomized controlled trials. Previous guidance has not always given special consideration to applying treatments and managing DDE in the context of the healthcare system. This consensus statement aims to assist practitioners in the field by providing a spectrum of acceptable opinions on DDE treatment and management from recognized experts in the field...
March 23, 2024: Ophthalmology and Therapy
https://read.qxmd.com/read/38524349/progression-of-diabetic-retinopathy-following-uncomplicated-phacoemulsification-a-prospective-study-from-south-india
#17
JOURNAL ARTICLE
R Sruthi, Seshadri J Saikumar, Mahesh Gopalakrishnan
AIM: The aim of this study was to study the progression of diabetic retinopathy (DR) and macular edema in uncomplicated phacoemulsification in patients with diabetes mellitus with a follow-up of 6 months. METHODS: A prospective, nonrandomized study was conducted on patients with established or no DR in a known case of diabetes mellitus undergoing cataract surgery by phacoemulsification, with no intraoperative complications. Detailed ophthalmic evaluation including fundus examination was done in all cases, and DR staging was done...
2024: Oman Journal of Ophthalmology
https://read.qxmd.com/read/38524324/comment-on-the-long-term-effect-of-panretinal-photocoagulation-on-optic-nerve-head-parameters-in-diabetic-retinopathy-using-heidelberg-retinal-tomography-iii
#18
JOURNAL ARTICLE
Pradeep Kumar Panigrahi
No abstract text is available yet for this article.
2024: Oman Journal of Ophthalmology
https://read.qxmd.com/read/38524319/phacoemulsification-in-patients-with-diabetic-macular-edema-a-real-world-data-of-75-eyes
#19
JOURNAL ARTICLE
Shikha Talwar Bassi, Shebin Salim, Ekta Rishi
PURPOSE: The purpose of this study was to evaluate the outcomes of phacoemulsification with intravitreal triamcinolone acetonide (IVTA) injection in patients with cataract and diabetic macular edema (DME) across the grades of diabetic retinopathy (DR). MATERIALS AND METHODS: It was a retrospective observational study. The study included 70 patients (75 eyes) with cataract and clinically significant macular edema in diabetics with nonproliferative (61 eyes) or proliferative (14 eyes) DR who underwent phacoemulsification with IVTA...
2024: Oman Journal of Ophthalmology
https://read.qxmd.com/read/38524313/optical-coherence-tomography-angiography-findings-of-prediabetic-patients
#20
JOURNAL ARTICLE
Sinan Emre, Cihan Altin, Mahmut Oguz Ulusoy, Elcin Aydin
PURPOSE: The purpose of this study was to evaluate prediabetic patients for microvascular changes using optical coherence tomography-angiography (OCT-A) and compare with diabetic patients and healthy controls. METHODS: OCT-A images of 60 eyes of 30 patients with diabetes mellitus (DM), 72 eyes of 36 prediabetic patients, and 108 eyes of 54 healthy controls were retrospectively evaluated and compared in this study. A swept-source OCTA (Triton, Topcon) instrument was used for collecting OCT-A images...
2024: Oman Journal of Ophthalmology
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