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https://www.readbyqxmd.com/read/29234807/development-and-validation-of-a-deep-learning-system-for-diabetic-retinopathy-and-related-eye-diseases-using-retinal-images-from-multiethnic-populations-with-diabetes
#1
Daniel Shu Wei Ting, Carol Yim-Lui Cheung, Gilbert Lim, Gavin Siew Wei Tan, Nguyen D Quang, Alfred Gan, Haslina Hamzah, Renata Garcia-Franco, Ian Yew San Yeo, Shu Yen Lee, Edmund Yick Mun Wong, Charumathi Sabanayagam, Mani Baskaran, Farah Ibrahim, Ngiap Chuan Tan, Eric A Finkelstein, Ecosse L Lamoureux, Ian Y Wong, Neil M Bressler, Sobha Sivaprasad, Rohit Varma, Jost B Jonas, Ming Guang He, Ching-Yu Cheng, Gemmy Chui Ming Cheung, Tin Aung, Wynne Hsu, Mong Li Lee, Tien Yin Wong
Importance: A deep learning system (DLS) is a machine learning technology with potential for screening diabetic retinopathy and related eye diseases. Objective: To evaluate the performance of a DLS in detecting referable diabetic retinopathy, vision-threatening diabetic retinopathy, possible glaucoma, and age-related macular degeneration (AMD) in community and clinic-based multiethnic populations with diabetes. Design, Setting, and Participants: Diagnostic performance of a DLS for diabetic retinopathy and related eye diseases was evaluated using 494 661 retinal images...
December 12, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29230409/relationship-of-obstructive-sleep-apnoea-with-diabetic-retinopathy-a-meta-analysis
#2
REVIEW
Zhenliu Zhu, Fengying Zhang, Yunxia Liu, Shuqin Yang, Chunting Li, Qingliang Niu, Jinming Niu
Until now, the relationship of obstructive sleep apnoea (OSA) with diabetic retinopathy (DR) was controversial. This meta-analysis was performed to obtain definitive conclusion on this topic. Relevant articles were searched on databases of Pubmed, Google Scholar, and Chinese National Knowledge Infrastructure (CNKI). The articles were selected according to inclusion and exclusion criteria. Odds ratio (OR) with 95% confidence interval (CI) was used to evaluate the relationship of OSA with risk of DR. I2 and P value were used to assess the presence of heterogeneity...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29229445/optical-coherence-tomography-angiography
#3
REVIEW
Richard F Spaide, James G Fujimoto, Nadia K Waheed, Srinivas R Sadda, Giovanni Staurenghi
Optical coherence tomography (OCT) was one of the biggest advances in ophthalmic imaging. Building on that platform, OCT angiography (OCTA) provides depth resolved images of blood flow in the retina and choroid with levels of detailed far exceeding that obtained with older forms of imaging. This new modality is challenging because of the need for new equipment and processing techniques, current limitations of imaging capability, and rapid advancements in both imaging and in our understanding of the imaging and applicable pathophysiology of the retina and choroid, and the requirement for understanding the origins of image artifacts...
December 8, 2017: Progress in Retinal and Eye Research
https://www.readbyqxmd.com/read/29227971/association-of-1082a-g-polymorphism-in-the-interleukin-10-gene-with-estimated-glomerular-filtration-rate-in-type-2-diabetes
#4
Evelise Regina Polina, Bruna Letícia da Silva Pereira, Daisy Crispim, Renan Cesar Sbruzzi, Luis Henrique Canani, Kátia Gonçalves Dos Santos
BACKGROUND/AIMS: The -1082A>G polymorphism (rs1800896) in the interleukin-10 (IL10) gene has been associated with type 2 diabetes and diabetic retinopathy, but its relationship with diabetic kidney disease (DKD) is uncertain. The aim of this case-control study was to investigate whether the -1082A>G polymorphism is associated with DKD in white Brazilians with type 2 diabetes mellitus. METHODS: Genotyping was done by real-time polymerase chain reaction for 597 type 2 diabetic outpatients...
December 8, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29227822/automated-retinal-health-diagnosis-using-pyramid-histogram-of-visual-words-and-fisher-vector-techniques
#5
Joel E W Koh, Eddie Y K Ng, Sulatha V Bhandary, Yuki Hagiwara, Augustinus Laude, U Rajendra Acharya
Untreated age-related macular degeneration (AMD), diabetic retinopathy (DR), and glaucoma may lead to irreversible vision loss. Hence, it is essential to have regular eye screening to detect these eye diseases at an early stage and to offer treatment where appropriate. One of the simplest, non-invasive and cost-effective techniques to screen the eyes is by using fundus photo imaging. But, the manual evaluation of fundus images is tedious and challenging. Further, the diagnosis made by ophthalmologists may be subjective...
December 5, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29225791/recent-advances-in-the-management-and-understanding-of-diabetic-retinopathy
#6
REVIEW
Matthew Powers, Margaret Greven, Robert Kleinman, Quan Dong Nguyen, Diana Do
Despite recent advances in the diagnosis and treatment of diabetic retinopathy, this complication remains a steadfast challenge to patients and physicians. This review summarizes recent progress in the diagnosis and management of diabetic retinopathy, including automated screening, optical coherence tomography, control of systemic risk factors, surgical techniques, laser treatment, and pharmaceutical treatment, including vascular endothelial growth factor inhibitors. Recent advances in pharmaceutical treatments, in particular, hold strong promise of halting and sometimes reversing the disease process...
2017: F1000Research
https://www.readbyqxmd.com/read/29225397/concurrent-oct-imaging-of-stimulus-evoked-retinal-neural-activation-and-hemodynamic-responses
#7
Taeyoon Son, Benquan Wang, Yiming Lu, Yanjun Chen, Dingcai Cao, Xincheng Yao
It is well established that major retinal diseases involve distortions of the retinal neural physiology and blood vascular structures. However, the details of distortions in retinal neurovascular coupling associated with major eye diseases are not well understood. In this study, a multi-modal optical coherence tomography (OCT) imaging system was developed to enable concurrent imaging of retinal neural activity and vascular hemodynamics. Flicker light stimulation was applied to mouse retinas to evoke retinal neural responses and hemodynamic changes...
2017: Proceedings of SPIE
https://www.readbyqxmd.com/read/29223467/does-insulin-therapy-matter-determinants-of-diabetes-care-outcomes
#8
Jennifer A Andersen, Larry Gibbs
OBJECTIVE: To evaluate adherence to care standards for people with diabetes (PWDs) on insulin therapy versus PWDs who are not on insulin therapy, controlling for social determinants. RESEARCH DESIGN AND METHODS: Utilizing the United States 2015 Behavioral Risk Factor Surveillance System Survey, this study used logistic regression analyses to estimate differences in self-care behaviors, healthcare provider quality of care, and diabetic complications for individuals on insulin therapy and individuals not on insulin therapy...
December 6, 2017: Primary Care Diabetes
https://www.readbyqxmd.com/read/29223225/poor-glycemic-control-as-a-risk-factor-for%C3%A2-pseudophakic-cystoid-macular-edema-in-patients-with-diabetes
#9
Petteri Ylinen, Ilkka Laine, Juha-Matti Lindholm, Raimo Tuuminen
PURPOSE: To specify the risk factors for pseudophakic cystoid macular edema (CME) in patients with diabetes. SETTING: Kymenlaakso Central Hospital, Unit of Ophthalmology, Kotka, Finland. DESIGN: Prospective case series. METHODS: Patients with type 1 or type 2 diabetes having routine cataract surgery were evaluated. Spectral-domain optical coherence tomography imaging was performed before surgery and 1 month postoperatively...
November 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/29220127/vascular-endothelial-growth-factor-inhibition-for-proliferative-diabetic-retinopathy-et-tu-brute
#10
EDITORIAL
Jakob Grauslund
No abstract text is available yet for this article.
December 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29217386/early-worsening-of-diabetic-retinopathy-after-rapid-improvement-of-blood-glucose-control-in-patients-with-diabetes
#11
REVIEW
S Feldman-Billard, É Larger, P Massin
AIM: To review the frequency, importance of and risk factors for "early worsening of diabetic retinopathy" (EWDR) after rapid improvement of blood glucose in patients with diabetes. METHODS: This was a systematic review of key references (PubMed 1980-2016) and the current international recommendations for the above-mentioned topics. RESULTS: EWDR has been described during intensive treatment (IT) in patients with uncontrolled type 1 or 2 diabetes, and after pancreas transplantation or bariatric surgery...
November 11, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/29217148/ethnic-differences-in-the-prevalence-and-risk-factors-of-diabetic-retinopathy-the-singapore-epidemiology-of-eye-diseases-study
#12
Gavin S Tan, Alfred Gan, Charumathi Sabanayagam, Yih Chung Tham, Kumari Neelam, Paul Mitchell, Jie Jin Wang, Ecosse L Lamoureux, Ching-Yu Cheng, Tien Y Wong
PURPOSE: To evaluate the prevalence and risk factors for diabetic retinopathy (DR) in the Singapore Epidemiology of Eye Diseases (SEED) Study. DESIGN: Population-based, cross-sectional study. PARTICIPANTS: Persons of Malay, Indian, and Chinese ethnicity aged 40+ years, living in Singapore. METHODS: Diabetes was defined as nonfasting plasma glucose ≥200 mg/dl (11.1 mmol/l), glycated hemoglobin A1c (HbA1c) >6.5%, self-reported physician-diagnosed diabetes, or the use of glucose-lowering medication...
December 4, 2017: Ophthalmology
https://www.readbyqxmd.com/read/29215958/postoperative-complications-of-pars-plana-vitrectomy-for-diabetic-retinal-disease
#13
Gary L Yau, Paolo S Silva, Paul G Arrigg, Jennifer K Sun
Despite recent advances in the medical management of diabetic retinal disease, there remain established indications for vitreoretinal surgery in the treatment of severe proliferative diabetic retinopathy. These include non-clearing vitreous hemorrhage and tractional retinal detachment. Advances in surgical instrumentation, technique, and experience have led to improved visual outcomes, as well as a corresponding decrease in the incidence of postoperative complications. However, the presence of systemic and ocular factors in diabetic patients increases the risk of adverse events compared to non-diabetic individuals...
December 7, 2017: Seminars in Ophthalmology
https://www.readbyqxmd.com/read/29215179/five-year-visual-outcome-among-people-with-correctable-visual-impairment-the-liwan-eye-study
#14
Lanhua Wang, Yanzhi Zhao, Xiaotong Han, Wenyong Huang, Guofu Huang, Mingguang He
IMPORTANCE: Longitudinal data on visual outcome of correctable visual impairments (VI) are of paramount importance for decision-maker to estimate burden and demand to treat avoidable VI. BACKGROUND: To assess the 5-year visual outcome among participants with correctable VI and to identify associated risk factors. DESIGN: Population-based longitudinal cohort study. PARTICIPANTS: Participants with correctable VI at baseline attended the 5-year follow-up visit of the Liwan Eye Study...
December 7, 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/29213353/resveratrol-prevents-ros-induced-apoptosis-in-high-glucose-treated-retinal-capillary-endothelial-cells-via-the-activation-of-ampk-sirt1-pgc-1%C3%AE-pathway
#15
Jun Li, Songping Yu, Jia Ying, Tianyan Shi, Peipei Wang
Resveratrol (RSV) is used as a protective therapy against diabetic retinopathy. However, the mechanism(s) underlying this protective effect has not been fully elucidated. Bovine retinal capillary endothelial cells (BRECs), an in vitro model, were used to investigate the mechanism of RSV. Our results showed that high glucose induced significant cellular apoptosis in BRECs, which was accompanied by increased intracellular levels of reactive oxygen species (ROS) and cleaved caspase-3. The glucose-induced apoptosis and ROS elevation were both inhibited by RSV...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29212365/impact-of-metabolic-control-on-macular-thickness-in-diabetic-macular-oedema
#16
Yi-Jie Peng, Meng-Ju Tsai
PURPOSE: To investigate the impact of metabolic control on macular thickness measured using optical coherence tomography in patients with diabetic retinopathy with or without macular oedema. METHODS: A total of 124 patients with diabetic retinopathy ( n = 70 without macular oedema and n = 54 with macular oedema) were enrolled. Optical coherence tomography parameters measured included central macular thickness and total macular volume. Metabolic factors with correlation to optical coherence tomography parameters were fasting plasma glucose, glycosylated haemoglobin, triglyceride, low-density lipoprotein and estimated glomerular filtration rate...
December 1, 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/29211719/inhibition-of-soluble-epoxide-hydrolase-prevents-diabetic-retinopathy
#17
Jiong Hu, Sarah Dziumbla, Jihong Lin, Sofia-Iris Bibli, Sven Zukunft, Julian de Mos, Khader Awwad, Timo Frömel, Andreas Jungmann, Kavi Devraj, Zhixing Cheng, Liya Wang, Sascha Fauser, Charles G Eberhart, Akrit Sodhi, Bruce D Hammock, Stefan Liebner, Oliver J Müller, Clemens Glaubitz, Hans-Peter Hammes, Rüdiger Popp, Ingrid Fleming
Diabetic retinopathy is an important cause of blindness in adults, and is characterized by progressive loss of vascular cells and slow dissolution of inter-vascular junctions, which result in vascular leakage and retinal oedema. Later stages of the disease are characterized by inflammatory cell infiltration, tissue destruction and neovascularization. Here we identify soluble epoxide hydrolase (sEH) as a key enzyme that initiates pericyte loss and breakdown of endothelial barrier function by generating the diol 19,20-dihydroxydocosapentaenoic acid, derived from docosahexaenoic acid...
December 6, 2017: Nature
https://www.readbyqxmd.com/read/29210634/preventive-and-therapeutic-potentials-of-anthocyanins-in-diabetes-and-associated-complications
#18
Swathi Putta, Nagendra Sastry Yarla, Eswar K Kumar, Dhananjaya Bhadrapura Lakkappa, Mohammad A Kamal, Luciana Scotti, Marcus T Scotti, Ghulam Md Ashraf, George E Barreto, B Sasi Bhusana Rao, D Sarala Kumari, Gorla V Reddy, Vadim V Tarasov, Sarat Babu Imandi, Gjumrakch Aliev
Diet is an essential factor affecting the development of and risk for diabetes mellitus. In search of preventative and therapeutic strategies, it is to be considering the potential role of certain foods and their bioactive compounds to prevent the pathogenesis associated with metabolic diseases. Human consumption of anthocyanins is among the highest of all flavonoids. Epidemiological studies have suggested that the consumption of anthocyanins lowers the risk of diabetes and diabetic complications. Anthocyanins are important natural bioactive pigments responsible for red to blue colour of fruits, leaves, seeds, stems and flowers, which are present in a variety of plant species particularly in berries and cherries...
December 5, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29210149/retinal-vascular-complications-associated-with-interferon-ribavirin-therapy-for-chronic-hepatitis-c-a-population-based-study
#19
Chien-Hsiung Lai, Yao-Hsu Yang, Pau-Chung Chen, Ying-Chi King, Chia-Yen Liu
PURPOSE: To investigate the incidence of retinal vascular complications and risk factors in patients with chronic hepatitis C receiving interferon-ribavirin therapy in Taiwan. METHODS: By using the Taiwan National Health Insurance Research Database, we compared the incidence of retinal vascular complications between patients receiving and not receiving interferon-ribavirin treatment. The exposure and nonexposure groups were randomly 1:1 frequency-matched according to age, sex, income, urbanization level, hypertension, and diabetes...
December 6, 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/29210010/management-of-diabetic-macular-edema-in-japan-a-review-and-expert-opinion
#20
REVIEW
Hiroko Terasaki, Yuichiro Ogura, Shigehiko Kitano, Taiji Sakamoto, Toshinori Murata, Akito Hirakata, Tatsuro Ishibashi
Diabetic retinopathy is a frequent cause of visual impairment in working-age adults (≥ 30 years) and in Japan is most commonly observed in those aged 50-69 years. Diabetic macular edema (DME) is one of the main causes of vision disturbance in diabetic retinopathy, which is a clinically significant microvascular complication of diabetes. Anti-vascular endothelial growth factor (VEGF) therapy is becoming the mainstay of treatment for DME. However, to achieve sustained long-term improvement in visual acuity, conventional laser photocoagulation, vitrectomy and steroid therapy are also expected to play a role in the treatment of DME...
December 5, 2017: Japanese Journal of Ophthalmology
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