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Diabetes,diabetic retinopathy

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https://www.readbyqxmd.com/read/28453510/is-aspirin-associated-with-diabetic-retinopathy-the-singapore-epidemiology-of-eye-disease-seed-study
#1
Yuan Shi, Yih-Chung Tham, Ning Cheung, Jacqueline Chua, Gavin Tan, Paul Mitchell, Jie Jin Wang, Yin Bun Cheung, Ching-Yu Cheng, Tien Yin Wong
BACKGROUND/AIMS: To determine the association between aspirin use and diabetic retinopathy (DR) among persons with diabetes, in a population-based, cross-sectional study. METHODS: Subjects with diabetes aged >40 years from the Singapore Epidemiology of Eye Diseases Study were enrolled in this study. Retinal photographs were graded for DR according to the modified Airlie House classification system. Vision threatening diabetic retinopathy (VTDR) was defined as the presence of severe non-proliferative DR, or proliferative DR, or clinically significant macular oedema...
2017: PloS One
https://www.readbyqxmd.com/read/28448726/intravitreal-injection-of-sulfamethoxazole-and-trimethoprim-associated-with-dexamethasone-as-an-alternative-therapy-for-ocular-toxoplasmosis
#2
Carlos E Souza, Heloisa Nascimento, Acácio Lima, Cristina Muccioli, Rubens Belfort
PURPOSE: To evaluate intravitreal injections of sulfamethoxazole/trimethoprim in association with dexamethasone for treating toxoplasmic retinochoroiditis. METHODS: Thirteen patients with active, recurrent ocular focal toxoplasmic retinochoroiditis and visual acuity worse than 20/63 in the affected eye were included. Ocular toxoplasmosis was diagnosed according to the classic clinical findings. The primary end point was the change in the final best-corrected visual acuity (BCVA)...
April 27, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/28448655/change-in-diabetic-retinopathy-through-2-years-secondary-analysis-of-a-randomized-clinical-trial-comparing-aflibercept-bevacizumab-and-ranibizumab
#3
Susan B Bressler, Danni Liu, Adam R Glassman, Barbara A Blodi, Alessandro A Castellarin, Lee M Jampol, Paul L Kaufman, Michele Melia, Harinderjit Singh, John A Wells
Importance: Anti-vascular endothelial growth factor (anti-VEGF) therapy for diabetic macular edema (DME) favorably affects diabetic retinopathy (DR) improvement and worsening. It is unknown whether these effects differ across anti-VEGF agents. Objective: To compare changes in DR severity during aflibercept, bevacizumab, or ranibizumab treatment for DME. Design, Setting, and Participants: Preplanned secondary analysis of data from a comparative effectiveness trial for center-involved DME was conducted in 650 participants receiving aflibercept, bevacizumab, or ranibizumab...
April 27, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28448646/diabetic-retinopathy-and-antivascular-endothelial-growth-factor-agents
#4
Shriji Patel, Paul Sternberg
No abstract text is available yet for this article.
April 27, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28447270/annual-incidences-of-visual-impairment-during-10-year-period-in-mie-prefecture-japan
#5
Kengo Ikesugi, Takako Ichio, Hideyuki Tsukitome, Mineo Kondo
PURPOSE: To determine the annual incidence of visual impairment in a Japanese population during a 10-year period. METHODS: We examined the physical disability certificates issued yearly between 2004 and 2013 in Mie prefecture, Japan. During this period 2468 visually impaired people were registered under the newly defined Act on Welfare of the Physically Disabled Persons' criteria. The age, sex distribution, and causes of visual impairment were determined from the certificates...
April 26, 2017: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28447229/pathogenic-role-and-therapeutic-potential-of-pleiotrophin-in-mouse-models-of-ocular-vascular-disease
#6
Weiwen Wang, Michelle E LeBlanc, Xiuping Chen, Ping Chen, Yanli Ji, Megan Brewer, Hong Tian, Samantha R Spring, Keith A Webster, Wei Li
Angiogenic factors play an important role in the pathogenesis of diabetic retinopathy (DR), neovascular age-related macular degeneration (nAMD) and retinopathy of prematurity (ROP). Pleiotrophin, a well-known angiogenic factor, was recently reported to be upregulated in the vitreous fluid of patients with proliferative DR (PDR). However, its pathogenic role and therapeutic potential in ocular vascular diseases have not been defined in vivo. Here using corneal pocket assays, we demonstrated that pleiotrophin induced angiogenesis in vivo...
April 26, 2017: Angiogenesis
https://www.readbyqxmd.com/read/28446148/circumpapillary-retinal-nerve-fiber-layer-thickness-anterior-lamina-cribrosa-depth-and-lamina-cribrosa-thickness-in-neovascular-glaucoma-secondary-to-proliferative-diabetic-retinopathy-a-cross-sectional-study
#7
Satoshi Yokota, Yuji Takihara, Yoshihiro Takamura, Masaru Inatani
BACKGROUND: To compare the lamina cribrosa between eyes with and without neovascular glaucoma (NVG) using enhanced depth imaging spectral-domain optical coherence tomography. METHODS: Forty-six patients with proliferative diabetic retinopathy were enrolled in this cross-sectional study. The patients were divided into two groups based on the absence or presence of NVG (the non-NVG group and the NVG group, respectively). The intraocular pressure (IOP), circumpapillary retinal nerve fiber layer (cpRNFL) thickness, anterior lamina cribrosa depth (ALD), and laminar thickness (LT) were compared between the groups...
April 26, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28444955/serum-uric-acid-levels-are-associated-with-increased-risk-of-newly-developed-diabetic-retinopathy-among-japanese-male-patients-with-type-2-diabetes-a-prospective-cohort-study-diabetes-distress-and-care-registry-at-tenri-ddcrt-13
#8
Hirohito Kuwata, Shintaro Okamura, Yasuaki Hayashino, Satoru Tsujii, Hitoshi Ishii
OBJECTIVE: We assessed the prospective association between baseline serum uric acid (SUA) levels and consequent risk of developing diabetic retinopathy (DR). RESEARCH DESIGN AND METHODS: Data for 1839 type 2 diabetes patients without DR were obtained from a Japanese diabetes registry. A Cox proportional hazards model with time-varying exposure information by sex was used and adjusted for potential confounders to assess the independent correlations between baseline SUA levels and incidence rate of DR...
April 26, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28444837/prevalence-and-risk-factors-for-diabetic-retinopathy-in-17%C3%A2-152-patients-from-the-island-of-funen-denmark
#9
Morten B Larsen, Jan Erik Henriksen, Jakob Grauslund, Tunde Peto
PURPOSE: This study aims to estimate the prevalence and risk factors of diabetic retinopathy (DR) in patients enrolled in a large Danish quality-assuring database for diabetes: the Funen Diabetes Database (FDDB). METHODS: All patients with type 1 (T1DM) and type 2 DM (T2DM) diabetes mellitus (DM) were included in a cross-sectional study. The level of DR per patient was determined based on the eye with highest level of DR. All ocular and non-ocular data were extracted at the latest examination that corresponded to the most recent DR-grading data...
April 26, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28442700/the-role-of-the-itln1-gene-rs2274907-polymorphism-in-diabetic-foot-patients
#10
Beata Mrozikiewicz-Rakowska, Agnieszka Sobczyk-Kopcioł, Konrad Szymański, Piotr Nehring, Patryk Szatkowski, Joanna Bartkowiak-Wieczorek, Anna Bogacz, Anna Aniszczuk, Wojciech Drygas, Rafał Płoski, Leszek Czupryniak
INTRODUCTION    Diabetic foot (DF) is a devastating complication of diabetes mellitus (DM) that occurs due to neuropathy and/or atherosclerosis of the lower limbs. Omentin (encoded by the ITLN1 gene) has been implicated as a protective factor in vascular complications of diabetes, likely due to its endothelial vasodilator activity and its anti-inflammatory actions. However, susceptibility to DF in terms of ITLN1 gene polymorphisms has not been studied. OBJECTIVES    This study aimed to evaluate the association between ITLN1 gene polymorphism rs2274907and the occurrence of DF in patients with type 2 diabetes mellitus (T2DM)...
April 25, 2017: Polish Archives of Internal Medicine
https://www.readbyqxmd.com/read/28440260/immortal-ozurdex-a-10-month-follow-up-of-an-intralenticular-implant
#11
B Poornachandra, Vinod B M Kumar, Chaitra Jayadev, Subashchandra H Dorelli, Naresh Kumar Yadav, Rohit Shetty
A 78-year-old male who had received a dexamethasone implant (Ozurdex, Allergan, Inc., Irvine, CA, USA) 15 days back for recalcitrant diabetic macular edema in the left eye came to us for a second opinion. On examination, his corrected distance visual acuity was 20/20 in the right eye and 20/40 in the left eye. Early cataractous changes were present in both eyes. The intraocular pressure was within normal limits. The Ozurdex implant was seen lodged in the posterior cortex of the crystalline lens in the left eye, confirmed on anterior segment optical coherence tomography (OCT) and ultrasound biomicroscopy...
March 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28440247/circulating-biomarkers-in-glaucoma-age-related-macular-degeneration-and-diabetic-retinopathy
#12
Madhu Nath, Nabanita Halder, Thirumurthy Velpandian
Biomarkers to predict the altering physiological conditions over the period leading toward the ocular disorders are of major importance in therapeutics. Isolation and validation of the biomarkers specific to ocular diseases are a challenging task. Glaucoma is a neurodegenerative disease of the eye where the correlation of biomarkers in circulating fluid may be made specific for the eye. However, conditions such as wet age-related macular degeneration (AMD) and proliferative diabetic retinopathy (DR), circulating biomarkers might be having some degree of overlap with other conditions like cancer where a common factor such as angiogenesis is involved...
March 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28439523/tsallis-entropy-and-sparse-reconstructive-dictionary-learning-for-exudate-detection-in-diabetic-retinopathy
#13
Vineeta Das, Niladri B Puhan
Computer-assisted automated exudate detection is crucial for large-scale screening of diabetic retinopathy (DR). The motivation of this work is robust and accurate detection of low contrast and isolated hard exudates using fundus imaging. Gabor filtering is first performed to enhance exudate visibility followed by Tsallis entropy thresholding. The obtained candidate exudate pixel map is useful for further removal of falsely detected candidates using sparse-based dictionary learning and classification. Two reconstructive dictionaries are learnt using the intensity, gradient, local energy, and transform domain features extracted from exudate and background patches of the training fundus images...
April 2017: Journal of Medical Imaging
https://www.readbyqxmd.com/read/28439518/diabetes-adult-neurogenesis-and-brain-remodeling-new-insights-from-rodent-and-zebrafish-models
#14
REVIEW
Anne-Claire Dorsemans, David Couret, Anaïs Hoarau, Olivier Meilhac, Christian Lefebvre d'Hellencourt, Nicolas Diotel
The prevalence of diabetes rapidly increased during the last decades in association with important changes in lifestyle. Diabetes and hyperglycemia are well-known for inducing deleterious effects on physiologic processes, increasing for instance cardiovascular diseases, nephropathy, retinopathy and foot ulceration. Interestingly, diabetes also impairs brain morphology and functions such as (1) decreased neurogenesis (proliferation, differentiation and cell survival), (2) decreased brain volumes, (3) increased blood-brain barrier leakage, (4) increased cognitive impairments, as well as (5) increased stroke incidence and worse neurologic outcomes following stroke...
2017: Neurogenesis (Austin, Tex.)
https://www.readbyqxmd.com/read/28438679/a-proposal-for-early-and-personalized-treatment-of-diabetic-retinopathy-based-on-clinical-pathophysiology-and-molecular-phenotyping
#15
Thomas W Gardner, Jeffrey M Sundstrom
This paper presents a new approach to the prevention and treatment of early stage diabetic retinopathy before vision is severely impaired. This approach includes two major steps. The first step is to understand the mechanisms of vision impairment and classify diabetic retinopathy on the basis of pathophysiologic adaptations, rather than on the presence of advanced pathologic lesions, as defined by current clinical practice conventions. The second step is to develop patient-specific molecular diagnoses of diabetic retinopathy so that patients can be treated based on their individual characteristics, a process analogous to the individualized diagnosis and treatment of cancer patients...
April 21, 2017: Vision Research
https://www.readbyqxmd.com/read/28438678/do-photoreceptor-cells-cause-the-development-of-retinal-vascular-disease
#16
Timothy S Kern
The retinal vasculature is affected in a number of clinically important retinopathies, including diabetic retinopathy. There has been a considerable amount of research into the pathogenesis of retinal microvascular diseases, but the potential contribution of the most abundant cell population in the retina, photoreceptor cells, has been largely overlooked. This review summarizes ongoing research suggesting that photoreceptor cells play a critical role in the development of retinal vascular disease in diabetic retinopathy and other retinopathies...
April 21, 2017: Vision Research
https://www.readbyqxmd.com/read/28438542/identification-of-low-micromolar-dual-inhibitors-for-aldose-reductase-alr2-and-poly-adp-ribose-polymerase-parp-1-using-structure-based-design-approach
#17
Navriti Chadha, Om Silakari
Clinical studies have revealed that diabetic retinopathy is a multifactorial disorder. Moreover, studies also suggest that ALR2 and PARP-1 co-occur in retinal cells, making them appropriate targets for the treatment of diabetic retinopathy. To find the dual inhibitors of ALR2 and PARP-1, the structure based design was carried out in parallel for both the target proteins. A series of novel thiazolidine-2,4-dione (TZD) derivatives were therefore rationally designed, synthesized and their in vitro inhibitory activities against ALR2 and PARP-1 were evaluated...
April 13, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28437472/socioeconomic-status-and-type-2-diabetes-complications-among-young-adult-patients-in-japan
#18
Mitsuhiko Funakoshi, Yasushi Azami, Hisashi Matsumoto, Akemi Ikota, Koichi Ito, Hisashi Okimoto, Nobuaki Shimizu, Fumihiro Tsujimura, Hiroshi Fukuda, Chozi Miyagi, Sayaka Osawa, Ryo Osawa, Jiro Miura
OBJECTIVE: To assess the relationship between socioeconomic status (SES) and complications of type 2 diabetes among young adults in Japan. DESIGN: A cross-sectional study. SETTING: Outpatient wards of 96 member hospitals and clinics of the Japan Federation of Democratic Medical Institutions. PARTICIPANTS: A total of 782 outpatients with type 2 diabetes (525 males, 257 females), aged 20-40 years as of March 31, 2012. After excluding 110 participants whose retinopathy diagnosis was in question, 672 participants were analyzed...
2017: PloS One
https://www.readbyqxmd.com/read/28436640/intravitreal-aflibercept-for-patients-with-diabetic-macular-edema-refractory-to-bevacizumab-or-ranibizumab-analysis-of-response-to-aflibercept
#19
Yen-Yi Chen, Pei-Yao Chang, Jia-Kang Wang
PURPOSE: To investigate the short-term efficacy and safety of intravitreal aflibercept in a case series of patients with diabetic macular edema (DME) refractory to ranibizumab or bevacizumab. DESIGN: A retrospective chart review. METHODS: From September 2013 to March 2016, we identified patients with DME who developed resistance to bevacizumab or ranibizumab. Three monthly intravitreal aflibercept injections were administered in refractory cases...
April 10, 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28436035/nap-counteracts-hyperglycemia-hypoxia-induced-retinal-pigment-epithelial-barrier-breakdown-through-modulation-of-hifs-and-vegf-expression
#20
Agata Grazia D'Amico, Grazia Maugeri, Daniela Maria Rasà, Valentina La Cognata, Salvatore Saccone, Concetta Federico, Sebastiano Cavallaro, Velia D'Agata
Diabetic macular edema (DME) is a common complication leading to a central vision loss in patients with diabetes. In this eye pathology, the hyperglycaemic/hypoxic microenvironment of pigmented epithelium is responsible for outer blood retinal barrier integrity changes. More recently, we have shown that a small peptide derived from the activity-dependent neuroprotective protein (ADNP), known as NAP, counteracts damages occurring during progression of diabetic retinopathy by modulating HIFs/VEGF pathway. Here, we have investigated for the first time the role of this peptide on outer blood retinal barrier (BRB) integrity exposed to hyperglycaemic/hypoxic insult mimicking a model in vitro of DME...
April 24, 2017: Journal of Cellular Physiology
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