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https://www.readbyqxmd.com/read/29040917/enhanced-diffusometric-immunosensing-with-grafted-gold-nanoparticles-for-detection-of-diabetic-retinopathy-biomarker-tumor-necrosis-factor-%C3%AE
#1
Han-Sheng Chuang, Yu-Ju Chen, Hui-Pin Cheng
Diffusometry is sensitive to geometric changes of particles. Target antigens can be detected through diffusivity changes resulting from their immunoreactions by functionalizing particle surface with a specific antibody. Considering that Brownian motion is a self-driven phenomenon, diffusometric immunosensing features several characteristics, such as no-washing steps, rapid detection, high flexibility, and high sensitivity. Until recently, this technique has been applied to many biomedical fields, such as monitoring of microorganism motility and diagnosis of diseases with biomarkers...
October 11, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29040280/quantitative-analysis-of-neural-tissues-around-the-optic-disc-after-panretinal-photocoagulation-in-patients-with-diabetic-retinopathy
#2
Hyun Seung Yang, June-Gone Kim, Jae Bong Cha, Young In Yun, Jong Hoon Park, Jong Eun Woo
In this retrospective cross-sectional study, we quantitatively analyzed the tomographic features in the neural tissues around the optic disc in patients with diabetic retinopathy with and without panretinal photocoagulation. We analyzed 206 eyes, comprising 33 normal eyes in subjects without diabetes (group I), 30 eyes without diabetic retinopathy (group II), 66 eyes with non-proliferative diabetic retinopathy (group III), 45 eyes with panretinal photocoagulation (group IV), and 32 eyes with normal tension glaucoma (group V)...
2017: PloS One
https://www.readbyqxmd.com/read/29040017/aralia-elata-miq-seem-extract-decreases-o-glcnac-transferase-expression-and-retinal-cell-death-in-diabetic-mice
#3
Yoon Sook Kim, Minjun Kim, Mee Young Choi, Dong Hoon Lee, Gu Seob Roh, Hyun Joon Kim, Sang Soo Kang, Gyeong Jae Cho, Ki Hun Park, Seong-Jae Kim, Ji-Myong Yoo, Wan Sung Choi
Aralia elata (Miq) Seem (AES) is a medicinal plant used in traditional Chinese and Korean medicine for the treatment of several diseases, including diabetes. This study aimed to investigate the neuroprotective effect of AES extract against high glucose-induced retinal injury in diabetic mice. AES extract (20 and 100 mg/kg body weight) was orally administered to control mice or mice with streptozotocin-induced diabetes. Protein levels of O-linked β-N-acetylglucosamine (O-GlcNAc) transferase (OGT), carbohydrate-responsive element-binding protein (ChREBP), sterol regulatory element-binding protein (SREBP)-1, thioredoxin-interacting protein (TXNIP), fatty acid synthase (FAS), and acetyl CoA carboxylase (ACC) were analyzed by western blotting...
October 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29033535/differential-association-of-elevated-inflammatory-cytokines-with-postoperative-fibrous-proliferation-and-neovascularization-after-unsuccessful-vitrectomy-in-eyes-with-proliferative-diabetic-retinopathy
#4
Shigeo Yoshida, Yoshiyuki Kobayashi, Shintaro Nakao, Yukio Sassa, Toshio Hisatomi, Yasuhiro Ikeda, Yuji Oshima, Toshihiro Kono, Tatsuro Ishibashi, Koh-Hei Sonoda
BACKGROUND: Pars plana vitrectomy is the only treatment for advanced proliferative diabetic retinopathy (PDR). However, vitrectomy is not always successful despite current progress in vitreoretinal surgical techniques. The aim of our study was to investigate whether the vitreal concentrations of MCP-1, IL-6, IL-8, and VEGF are elevated after unsuccessful vitrectomy in patients with PDR and to investigate whether the altered levels of these cytokines are associated with the cause for the reoperation...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29032195/global-causes-of-blindness-and-distance-vision-impairment-1990-2020-a-systematic-review-and-meta-analysis
#5
Seth R Flaxman, Rupert R A Bourne, Serge Resnikoff, Peter Ackland, Tasanee Braithwaite, Maria V Cicinelli, Aditi Das, Jost B Jonas, Jill Keeffe, John H Kempen, Janet Leasher, Hans Limburg, Kovin Naidoo, Konrad Pesudovs, Alex Silvester, Gretchen A Stevens, Nina Tahhan, Tien Y Wong, Hugh R Taylor
BACKGROUND: Contemporary data for causes of vision impairment and blindness form an important basis of recommendations in public health policies. Refreshment of the Global Vision Database with recently published data sources permitted modelling of cause of vision loss data from 1990 to 2015, further disaggregation by cause, and forecasts to 2020. METHODS: In this systematic review and meta-analysis, we analysed published and unpublished population-based data for the causes of vision impairment and blindness from 1980 to 2014...
October 10, 2017: Lancet Global Health
https://www.readbyqxmd.com/read/29031855/furin-deficiency-in-myeloid-cellsleads-to-attenuated-revascularization-in-a-mouse-model-of-oxygen-induced-retinopathy
#6
Maria Vähätupa, Zuzet Martinez Cordova, Saara Aittomäki, Hannu Uusitalo, Tero A H Järvinen, Marko Pesu, Hannele Uusitalo-Järvinen
Diabetic retinopathy is a vision-threatening disease associated chronic retinal inflammation and hypoxia leading to abnormal angiogenesis. Furin, a member of the proprotein convertase family of proteins, has been implicated in the regulation of angiogenesis due to its essential role in the activation of several angiogenic growth factors, including vascular endothelial growth factor-C (VEGF-C), VEGF-D and transforming growth factor - β (TGF- β). In the present study, we evaluated expression of furin in the retina and its role in retinal angiogenesis...
October 12, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/29031854/angptl-4-induces-diabetic-retinal-inflammation-by-activating-profilin-1
#7
Qianyi Lu, Peirong Lu, Wei Chen, Li Lu, Zhi Zheng
Diabetic retinopathy (DR), the most common cause of irreversible blindness in working-age adults, results in central vision loss that is caused by microvascular damage to the inner lining of the back of the eye, the retina. The aim of this work was to assess the temporal relationships between angiopoietin-like protein-4 (ANGPTL-4), a novel adipocytokine factor, and diabetic retinal inflammation and microvascular dysfunction. The downstream pathway(s) and upstream mediator(s) of ANGPTL-4 were then determined under high glucose (HG) conditions...
October 12, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/29030794/vegf-a-gene-polymorphisms-and-responses-to-intravitreal-ranibizumab-treatment-in-patients-with-diabetic-macular-edema
#8
Mehmet Tetikoğlu, Zafer Yüksel, Serdar Aktas, Haci Murat Sağdik, Fatih Özcura
PURPOSE: To investigate the association between VEGF gene polymorphisms and the responses to treatment with intravitreal ranibizumab (IVR) in patients with diabetic macular edema (DME). METHODS: This prospective study, conducted at the Kutahya Dumlupinar University Faculty of Medicine, included 95 patients with DME that were treated with IVR and 32 patients without DME despite proliferative diabetic retinopathy (PDR). The participants were divided into three groups: DME with non-proliferative diabetic retinopathy, DME with PDR, and PDR without DME; patients with DME who were treated with IVR were further divided into two groups based on their response to the treatment...
October 13, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/29027826/dietary-advanced-glycated-end-products-and-medicines-influence-the-expression-of-sirt1-and-ddost-in-peripheral-mononuclear-cells-from-long-term-type-1-diabetes-patients
#9
Daniele P Santos-Bezerra, Adriana Machado-Lima, Maria Beatriz Monteiro, Sharon N Admoni, Ricardo V Perez, Cleide G Machado, Maria Heloíza Shimizu, Ana M Cavaleiro, Karina Thieme, Márcia S Queiroz, Ubiratan F Machado, Daniel Giannella-Neto, Marisa Passarelli, Maria Lúcia Corrêa-Giannella
Quantitative polymerase chain reaction was employed to quantify expression of two genes coding for advanced glycation end-product receptors [RAGE ( AGER) and AGER1 ( DDOST)] and of the gene coding the deacetylase SIRT1 ( SIRT1) in peripheral blood mononuclear cells from type 1 diabetes patients without [Group A, n = 35; 28.5 (24-39) years old; median (interquartile interval)] or with at least one microvascular complication [Group B, n = 117; 34.5 (30-42) years old]; 31 healthy controls were also included. In a subgroup of 48 patients, daily advanced glycation end-products intake before blood collection was assessed...
October 1, 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/29026201/dual-contribution-of-trpv4-antagonism-in-the-regulatory-effect-of-vasoinhibins-on-blood-retinal-barrier-permeability-diabetic-milieu-makes-a-difference
#10
David Arredondo Zamarripa, Ramsés Noguez Imm, Ana María Bautista Cortés, Osvaldo Vázquez Ruíz, Michela Bernardini, Alessandra Fiorio Pla, Dimitra Gkika, Natalia Prevarskaya, Fernando López-Casillas, Wolfgang Liedtke, Carmen Clapp, Stéphanie Thébault
Breakdown of the blood-retinal barrier (BRB), as occurs in diabetic retinopathy and other chronic retinal diseases, results in vasogenic edema and neural tissue damage, causing vision loss. Vasoinhibins are N-terminal fragments of prolactin that prevent BRB breakdown during diabetes. They modulate the expression of some transient receptor potential (TRP) family members, yet their role in regulating the TRP vanilloid subtype 4 (TRPV4) remains unknown. TRPV4 is a calcium-permeable channel involved in barrier permeability, which blockade has been shown to prevent and resolve pulmonary edema...
October 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29026186/about-bariatric-surgery-and-diabetic-retinopathy-the-debate-continues
#11
A E Pontiroli, C Merlotti, V Ceriani, A Morabito
No abstract text is available yet for this article.
October 13, 2017: Eye
https://www.readbyqxmd.com/read/29023269/all-probe-vitrectomy-dissection-techniques-for-diabetic-tractional-retinal-detachments-lift-and-shave
#12
María H Berrocal
To describe a technique to relieve traction, remove fibrovascular tissue, and reattach the retina in cases of tractional retinal detachment secondary to complications of diabetes using only the vitrectomy probe. PURPOSE: To describe the all-probe lift and shave technique to remove fibrovascular tissue and repair diabetic retinal detachments. Anatomical and visual acuity outcomes with this technique are presented. METHODS: In this single surgeon, retrospective review of a consecutive series of eyes with tractional retinal detachment associated with diabetic retinopathy repaired with probe-only dissection techniques...
October 11, 2017: Retina
https://www.readbyqxmd.com/read/29023230/a-diabetic-retinopathy-screening-tool-for-low-income-adults-in-mexico
#13
Kenny Mendoza-Herrera, Amado D Quezada, Andrea Pedroza-Tobías, Cesar Hernández-Alcaraz, Jans Fromow-Guerra, Simón Barquera
INTRODUCTION: A national diabetic retinopathy screening program does not exist in Mexico as of 2017. Our objective was to develop a screening tool based on a predictive model for early detection of diabetic retinopathy in a low-income population. METHODS: We analyzed biochemical, clinical, anthropometric, and sociodemographic information from 1,000 adults with diabetes in low-income communities in Mexico (from 11,468 adults recruited in 2014-2016). A comprehensive ophthalmologic evaluation was performed...
October 12, 2017: Preventing Chronic Disease
https://www.readbyqxmd.com/read/29023169/associations-of-physical-activity-and-sedentary-behaviour-with-vision-threatening-diabetic-retinopathy-in-indonesian-population-with-type-2-diabetes-mellitus-jogjakarta-eye-diabetic-study-in-the-community-joged-com
#14
D P Dharmastuti, A N Agni, F Widyaputri, S Pawiroranu, Z M Sofro, F S Wardhana, S Haryanto, T W Widayanti, S Kotha, P Gupta, M B Sasongko
PURPOSE: To investigate the association of physical activity (PA) and sedentary behaviour with diabetic retinopathy (DR) in type 2 diabetes adults. METHODS: A community-based cross-sectional study of adults with type 2 diabetes. DR was assessed from disc- and macula-centred fundus photograph, and categorised into mild, moderate non-proliferative DR (NPDR), and Vision-Threatening DR (VTDR). Worse eye was used to determine the person's DR severity. PA was assessed using WHO Global Physical Activity Questionnaire (GPAQ)...
October 12, 2017: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/29022954/agreement-on-diabetic-retinopathy-grading-in-fundus-photographs-by-allied-ophthalmic-personnel-as-compared-to-ophthalmologist-at-a-community-setting-in-nepal
#15
Raba Thapa, Sanyam Bajimaya, Eli Pradhan, Govinda Paudyal
INTRODUCTION: Diabetic retinopathy (DR) is the emerging cause of blindness in the developing world. Timely detection of DR could save vision from its avoidable blinding condition. OBJECTIVE: To assess the accuracy of DR grading in fundus photographs by the allied ophthalmic personnel (AOP) as compared to ophthalmologist at a community setting in Nepal. MATERIALS AND METHODS: Fundus photographs of known diabetes subjects attending for DR screening were graded by two groups of AOP and ophthalmologist...
January 2017: Nepalese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29022506/autologous-cell-therapy-for-vascular-regeneration-the-role-of-proangiogenic-cells
#16
Vanessa Bianconi, Francesca Fallarino, Massimo Raffaele Mannarino, Francesco Bagaglia, Meisam Naeimi Kararoudi, Caterina Oriana Aragona, Rita Romani, Matteo Pirro
Autologous cell therapy represents a novel treatment option for vascular regeneration in different disease conditions. Both experimental and clinical studies indicate a therapeutic potential for different proangiogenic cells (PCs), including endothelial progenitor cells (EPCs) in the treatment of peripheral artery disease. A significant improvement of ischemic symptoms has been reported in different trials evaluating PCs for the treatment of critical limb ischemia. However, contrasting results from different meta-analyses question the efficacy of PC-based approaches on long-term outcomes, including amputation and survival...
October 12, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29022292/changes-in-macular-retinal-layers-and-peripapillary-nerve-fiber-layer-thickness-after-577-nm-pattern-scanning-laser-in-patients-with-diabetic-retinopathy
#17
Ji Soo Shin, Young Hoon Lee
PURPOSE: The aim of this study was to evaluate the changes in thickness of each macular retinal layer, the peripapillary retinal nerve fiber layer (RNFL), and central macular thickness (CMT) after 577-nm pattern scanning laser (PASCAL) photocoagulation in patients with diabetic retinopathy. METHODS: This retrospective study included 33 eyes with diabetic retinopathy that underwent 577-nm PASCAL photocoagulation. Each retinal layer thickness, peripapillary RNFL thickness, and CMT were measured by spectral-domain optical coherence tomography before 577-nm PASCAL photocoagulation, as well as at 1, 6, and 12 months after 577-nm PASCAL photocoagulation...
August 26, 2017: Korean Journal of Ophthalmology: KJO
https://www.readbyqxmd.com/read/29022053/glycated-albumin-ga-and-inflammation-role-of-ga-as-a-potential-marker-of-inflammation
#18
REVIEW
H Vernon Roohk, Asad R Zaidi, Dimple Patel
AIMS: Abnormal levels of glycated albumin (GA) are associated with the onset of both diabetes and inflammation. Although inflammation has long been associated with diabetes, this article aims to explore the underlying mechanisms of this relationship as it pertains to the role of GA. METHODS: We have reviewed 52 research articles since the year 2000. Common search terms used were "(inflammatory mediator) and GA" or "inflammation and GA". The findings have been organized according to diabetic complications with respect to the interactions of GA and inflammatory mediators...
October 11, 2017: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/29020428/improvement-of-recalcitrant-diabetic-macular-edema-after-peritoneal-dialysis
#19
Sally S Ong, Akshay S Thomas, Sharon Fekrat
Nephropathy may be an independent and contributory risk factor for diabetic macular edema (DME). A 69-year-old man who had previously been treated with panretinal laser photocoagulation for proliferative diabetic retinopathy as well as with steroid and anti-vascular endothelial growth factor injections for DME declined additional treatment for the DME, which was worse in the right eye. The DME was observed without further treatment for the next 36 months. Despite well-controlled blood sugar, blood pressure, and lipid levels, the DME remained unchanged...
October 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/29020426/aflibercept-in-serous-foveal-detachment-in-dome-shaped-macula-short-term-results-in-a-retrospective-study
#20
Giovanni Giacomelli, Rita Mencucci, Andrea Sodi, Ilaria Biagini, Giacomo Abbruzzese, Matteo Giuntoli, Stanislao Rizzo, Gianni Virgili
BACKGROUND AND OBJECTIVE: To evaluate short-term efficacy of intravitreal aflibercept (Eylea; Regeneron, Tarrytown, NY) in serous foveal detachment (SFD) in dome-shaped macula (DSM). PATIENTS AND METHODS: A retrospective, noncomparative case series. Three monthly aflibercept injections were administered. Early Treatment Diabetic Retinopathy Study best-corrected visual acuity (BCVA), optical coherence tomography central subfield thickness (CST), and subretinal fluid (SRF) at baseline and at 2 months and 4 months after the last injection were considered for statistical analysis...
October 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
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