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Pericarditis

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https://www.readbyqxmd.com/read/29139135/phase-1-study-of-quizartinib-in-combination-with-induction-and-consolidation-chemotherapy-in-patients-with-newly-diagnosed-acute-myeloid-leukemia
#1
Jessica K Altman, James M Foran, Keith W Pratz, Denise Trone, Jorge E Cortes, Martin S Tallman
Novel therapies have potential to improve outcomes in patients with acute myeloid leukemia (AML) harboring FLT3-ITD mutations that have high risk of relapse and poor survival following standard of care (SOC) cytarabine/anthracycline-based induction/consolidation chemotherapy. Quizartinib is a selective and highly potent FLT3 inhibitor that has shown strong single-agent activity in relapsed or refractory (R/R) AML. This phase 1, open-label, sequential group dose-escalation trial (NCT 01390337) is the first evaluating safety and tolerability of quizartinib in combination with SOC chemotherapy in newly diagnosed AML (ndAML)...
November 15, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/29132918/the-first-in-human-experience-with-a-minimally-invasive-ambulatory-counterpulsation-heart-assist-system-for-advanced-congestive-heart-failure
#2
Valluvan Jeevanandam, Tae Song, David Onsager, Takeyoshi Ota, Colleen Juricek LaBuhn, Thomas Lammy, Gabriel Sayer, Gene Kim, Sonna Patel-Raman, Nir Uriel
BACKGROUND: The intravascular ventricular assist system (iVAS) is a new, minimally invasive, ambulatory counterpulsation heart assist system delivered via the subclavian artery and powered by a portable driver. It is designed for recovery, bridge to transplantation (BTT) or for prolonging medical therapy. We report the first-in-human (FIH) experience with iVAS. METHODS: This is a prospective, non-randomized single arm, U.S. Food and Drug Administration (FDA)-approved early feasibility trial in patients listed for cardiac transplantation...
November 10, 2017: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/29122457/radiotherapy-for-tracheal-bronchial-cystic-adenoid-carcinomas
#3
A Levy, A Omeiri, E Fadel, C Le Péchoux
AIMS: Primary tracheal-bronchial adenoid cystic carcinoma (thoracic adenoid cystic carcinoma; TACC) is a rare and aggressive malignant tumour. Radiotherapy results have not been previously individualised in this setting. PATIENTS AND METHODS: Records of 31 patients with TACC (74% tracheal and 26% bronchial) who received radiotherapy between February 1984 and September 2014 were retrospectively analysed. RESULTS: Surgical removal of the primary tumour was carried out for most (71%) patients, and 13/22 (59%) had R1 or R2 (1/22) margins...
November 6, 2017: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/29118999/associates-and-predictors-of-pleurisy-or-pericarditis-in-sle
#4
Seungwon Ryu, Wei Fu, Michelle A Petri
Background/Purpose: Serositis is one of both ACR and SLICC classification criteria for systemic lupus erythematosus (SLE) and a common type of extra renal flare. However, little is known about clinical or immunological associations of pleurisy or pericarditis. The aim of this study is to analyze associates and predictors of pleurisy versus pericarditis in Caucasians and African Americans with SLE. Methods: 2,390 SLE patients in the Hopkins Lupus Cohort were analyzed for demographic, clinical and serologic associates of pleurisy or pericarditis, defined using the SELENA revision of the SLE Disease Activity Index (SLEDAI)...
2017: Lupus Science & Medicine
https://www.readbyqxmd.com/read/29107356/a-systematic-review-of-the-efficacy-and-safety-of-intrapericardial-fibrinolysis-in-patients-with-pericardial-effusion
#5
Alison B Wiyeh, Eleanor A Ochodo, Charles S Wiysonge, Aloysious Kakia, Abolade A Awotedu, Arsen Ristic, Bongani M Mayosi
Pericardial effusion is the abnormal accumulation of fluid in the pericardial space. The complications of pericardial effusion can either be acute (e.g., cardiac tamponade) or chronic (e.g., constrictive pericarditis). We have conducted a systematic review of the scientific literature to evaluate the efficacy and safety of intrapericardial fibrinolysis in preventing complications of pericardial effusion. We searched for both published and unpublished studies. 29 studies, with a total of 109 patients were included in this review; 17 case reports, 11 case series, and one randomised controlled trial (RCT)...
October 26, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/29106473/trends-in-acute-pericarditis-hospitalizations-and-outcomes-among-the-elderly-in-the-united-states-1999-2012
#6
Purav Mody, Behnood Bikdeli, Yun Wang, Massimo Imazio, Harlan M Krumholz
Aim: The elderly are at risk of pericarditis from conditions such as malignancy, renal disease and after cardiac surgery. However, the burden of pericarditis and especially long-term outcomes associated with pericarditis have not been described before among the elderly. Methods and results: We examined hospitalization rates; in-hospital, 30-day, and 1-year all-cause mortality rates; all-cause 30-day readmission rates; length of stay and healthcare expenditure for Medicare beneficiaries aged 65 years or older with a principal discharge diagnosis of pericarditis from 1999 to 2012...
November 2, 2017: European Heart Journal. Quality of Care & Clinical Outcomes
https://www.readbyqxmd.com/read/29103684/age-susceptibility-of-caesarian-derived-colostrum-deprived-pigs-to-mycoplasma-hyorhinis-challenge
#7
Brian Martinson, F C Minion, Jeremy Kroll, Joseph Hermann
Mycoplasma hyorhinis (MHR) is a major cause of lameness, arthritis, and polyserositis among growing pigs. Reduced performance and culling due to MHR infection result in economic losses in swine production. We have previously developed an MHR challenge model in seven week-old CDCD pigs using cell-associated challenge material which results in both severe pericarditis and lameness. In this study we sequentially challenged CDCD pigs at seven, ten, thirteen, and sixteen weeks of age. Lameness was observed in >60% of the animals in the first three age groups but only 33% in the oldest age group...
October 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/29101915/pericarditis
#8
Atifur Rahman, Avadhesh Saraswat
BACKGROUND: Pericarditis is an important diagnosis to consider, along with various other differential diagnoses, in a patient who presents with chest pain. OBJECTIVE: This article describes in detail the common features, management and complications of pericarditis in the general practice setting. DISCUSSION: Characteristic clinical findings in pericarditis include pleuritic chest pain and pericardial friction rub on auscultation of the left lower sternal border...
November 2017: Australian Family Physician
https://www.readbyqxmd.com/read/29097843/a-case-report-of-ventricular-septal-defect-in-an-adult-sprague-dawley-rat
#9
Tetsuro Kurotaki, Yuki Tomonari, Junko Sato, Takeshi Kanno, Minoru Tsuchitani
A 20-week-old male Sprague Dawley rat noted with decreased body weight, dyspnea, and anorexia beginning 2 days before death was necropsied in the recovery period of a sub-chronic toxicity study. The heart was severely enlarged (30 × 20 × 20 mm), 3-4 times larger than normal, with an approximately 6 mm wide defect in the upper, membranous portion of the ventricular septum. Both ventricles measured 4 mm in thickness, and the right ventricle was 4 times thicker than normal. According to a microscopic examination, the myocardial fibers were severely hypertrophic in the right ventricle and mildly hypertrophic in the left ventricle and septum...
October 2017: Journal of Toxicologic Pathology
https://www.readbyqxmd.com/read/29096007/diagnosis-of-active-pericarditis-by-positron-emission-tomography-pet-cardiac-magnetic-resonance-cmr-imaging
#10
Bo Xu, Steve Shih-Lin Huang, Christine Jellis, Scott D Flamm
No abstract text is available yet for this article.
October 31, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29094181/cardiovascular-disease-in-patients-with-autoinflammatory-syndromes
#11
REVIEW
Rainer Hintenberger, Agnes Falkinger, Kathrin Danninger, Herwig Pieringer
Autoinflammatory syndromes (AIS) are characterized by recurring events of inflammation, leading to a variety of organ manifestations and fever attacks. A subgroup of AIS is commonly referred to as hereditary periodic fever syndromes (HPFS). There is substantial evidence that autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus are strongly associated with cardiovascular morbidity and mortality. The link between AIS and cardiovascular disease is not that clear, even if the concept of continuous inflammation as a risk factor for cardiovascular disease is widely accepted...
November 1, 2017: Rheumatology International
https://www.readbyqxmd.com/read/29093314/infective-endocarditis-complicated-by-intraventricular-abscesses-pericarditis-and-mycotic-aneurysm-due-to-an-emerging-strain-of-serotype-vi-streptococcus-agalactiae
#12
Nobuyasu Hirai, Kei Kasahara, Kenji Uno, Yoshihiko Ogawa, Taku Ogawa, Shinsuke Yonekawa, Ryuichi Nakano, Hisakazu Yano, Azusa Sakagami, Takayuki Uemura, Hiroyuki Okura, Yoshihiko Saito, Masahide Yoshikawa, Keiichi Mikasa
  An increasing number of invasive infections due to Streptococcus agalactiae in non-pregnant adults have been reported. We report a case of infective endocarditis complicated by intraventricular abscesses, pericarditis, and mycotic aneurysm due to S. agalactiae belonging to ST681 with a capsular serotype VI in a diabetic woman. The patient also had a myocardial infarction and was treated with percutaneous coronary intervention, pericardiocentesis, and 6 weeks of antibiotic treatment. Invasive infections due to serotype VI S...
October 31, 2017: Japanese Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29082045/h-capsulatum-a-not-so-benign-cause-of-pericarditis
#13
Paolo K Soriano, Muhammad Iqbal, Shakthishri Kandaswamy, Sami Akram, Abhishek Kulkarni, Tamer Hudali
The common causes of pericarditis and its course are benign in the majority of cases. Thus, further testing is usually not pursued and treatment for a presumptive viral etiology with nonsteroidal agents and steroids has been an accepted strategy. We present a patient with pericarditis who was unresponsive to first-line therapy and was subsequently found to have necrotizing granulomas of the pericardium with extensive adhesions and fungal elements seen on tissue biopsy. Serologic testing confirms active H. capsulatum infection, and he responded well to Itraconazole treatment...
2017: Case Reports in Cardiology
https://www.readbyqxmd.com/read/29080093/effectiveness-and-long-term-outcomes-of-surgical-intervention-for-constrictive-epicardium-in-constrictive-pericarditis
#14
Yangsin Lee, Yoshihiro Naruse, Keita Tanaka
OBJECTIVE: Epicardial resection is considered effective in patients with constrictive pericarditis accompanied by epicardial constriction, but few publications have evaluated its long-term outcomes. The study objective was to evaluate early and late results of epicardial resection. METHODS: A total of 22 patients with pericardiectomy for constrictive pericarditis were treated at our institution between 1989 and 2016. They were stratified by the presence or absence of constrictive epicardium and the surgical intervention performed...
October 27, 2017: General Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29080058/pericarditis-associated-with-cytarabine-therapy-for-acute-myelocytic-leukemia-a-case-report
#15
Xia Yang, Wei Liu, Allie Lyons, Zaiwei Song, Suodi Zhai, Kai Hu
BACKGROUND: The incidence of cytarabine-induced pericarditis is rare. So far, only a few cases have been reported worldwide. DESCRIPTION OF THE CASE: We are reporting a case of a 25-year-old male with acute myeloid leukemia (AML M2a) on chemotherapy who developed acute pericarditis after the administration of a cytarabine-containing regimen. The symptoms gradually improved after symptomatic treatment with steroids and other drugs. CONCLUSIONS: This case demonstrates that, although pericarditis induced by cytarabine is rare, early recognition of this potentially life-threatening complication and appropriate management will usually result in the patient's recovery...
October 27, 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29076895/primary-pericardial-angiosarcoma-shown-on-fdg-pet-ct
#16
Ximin Shi, Fang Li
A 63-year-old woman had persistent bloody pericardial effusion. Tuberculous pericarditis was initially suspected, but empirical antituberculosis therapy was futile. FDG PET/CT study revealed abnormal FDG activity in multiple parts of the pericardium, especially along with aorta and main pulmonary artery, and in the left atrium. However, there was no abnormal activity in other parts of the body. Histopathologic examination revealed primary pericardial angiosarcoma.
October 26, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29067848/distinct-clinical-correlates-of-immune-thrombocytopenic-purpura-at-diagnosis-of-childhood-onset-and-adult-sle
#17
Gladys Cherres Xavier Esteves, Natali Weniger Spelling Gormezano, Oriany L Pereira, David Kern, Clovis Almeida Silva, Rosa Maria Rodrigues Pereira, Katia Tomie Kozu, Eloisa Bonfá, Nadia Emi Aikawa
OBJECTIVES: To compare clinical and laboratorial features between childhood-onset systemic lupus erythematosus (cSLE) and adult SLE (aSLE) at concomitant diagnosis of immune thrombocytopenic purpura (ITP). METHODS: This study evaluated 56 cSLE and 73 aSLE patients regularly followed at Pediatric and Rheumatology Divisions of the same University hospital with ITP (platelets count <100,000/mm(3) in the absence of other causes) at lupus onset. RESULTS: Median current age was 11...
October 25, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/29064084/adverse-cardiac-events-in-out-patients-initiating-clozapine-treatment-a-nationwide-register-based-study
#18
C Rohde, C Polcwiartek, K Kragholm, B H Ebdrup, D Siskind, J Nielsen
OBJECTIVE: Using national Danish registers, we estimated rates of clozapine-associated cardiac adverse events. Rates of undiagnosed myocarditis were estimated by exploring causes of death after clozapine initiation. METHOD: Through nationwide health registers, we identified all out-patients initiating antipsychotic treatment (January 1, 1996-January 1, 2015). Rates of clozapine-associated myocarditis and pericarditis within 2 months from clozapine initiation and rates of cardiomyopathy within 1-2 years from clozapine initiation were compared to rates for other antipsychotics...
October 24, 2017: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/29062196/pathology-and-immunohistochemistry-study-of-newcastle-disease-field-case-in-chicken-in-indonesia
#19
Etriwati, Dewi Ratih, Ekowati Handharyani, Surachmi Setiyaningsih
AIM: The aim of the study was to examine pathology and the distribution pattern of Newcastle disease virus (NDV) in internal organs of chickens from a field case using immunohistochemical staining. MATERIALS AND METHODS: 10 groups of broiler, layer, and domestic chicken were collected from necropsy room Division of Pathology, Bogor Agricultural University. These chickens were originated from West Java and collected based on pathologist diagnosis as suspect of Newcastle disease (ND)...
September 2017: Veterinary World
https://www.readbyqxmd.com/read/29059035/nocardia-beijingensis-pericarditis-presenting-with-cardiac-tamponade-a-case-report
#20
Nattinee Laksananun, Parichat Salee, Quanhathai Kaewpoowat
We report the first case of Nocardia beijingensis pericarditis in a 32-year-old HIV-infected patient. He presented with cardiac tamponade after failing to respond to treatment for smear-negative pulmonary and pericardial tuberculosis (TB). The pericardial fluid was examined several times before it eventually revealed filamentous branching organisms in Gram and modified acid-fast bacilli stain. The culture grew Nocardia spp. and was identified by 16s rRNA sequencing as N. beijingensis. Eight previously reported cases of Nocardia pericarditis in HIV-infected patients were caused by Nocardia asteroides...
January 1, 2017: International Journal of STD & AIDS
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