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Tafeng Hu, Junji Cao, Chongshu Zhu, Zhuzi Zhao, Suixin Liu, Daizhou Zhang
Many studies indicate that the atmospheric environment over the southern part of the Tibetan Plateau is influenced by aged biomass burning particles that are transported over long distances from South Asia. However, our knowledge of the particles emitted locally (within the plateau region) is poor. We collected aerosol particles at four urban sites and one remote glacier site during a scientific expedition to the southeastern Tibetan Plateau in spring 2010. Weather and backward trajectory analyses indicated that the particles we collected were more likely dominated by particles emitted within the plateau...
February 14, 2018: Science of the Total Environment
José Bueno-Lledó, Antonio Torregrosa, Raquel Jiménez, Providencia García Pastor
INTRODUCTION: Preoperative progressive pneumoperitoneum (PPP) and botulinum toxin type A (BT) are tools in the surgical preparation of patients with loss of domain hernias (LODH). The aim of this paper is to report our experience with these preoperative techniques in 70 patients with LODH. METHODS: Observational study of 70 consecutive patients with LODH was conducted between May 2010 and May 2016. Diameters of the hernia sac, incisional hernia (VIH), and abdominal cavity (VAC) volumes, and VIH/VAC ratio were measured before and after PPP and BT, using abdominal CT scan data...
February 15, 2018: Surgical Endoscopy
Akihiro Sugai, Taisuke Kato, Akihide Koyama, Yuka Koike, Sou Kasahara, Takuya Konno, Tomohiko Ishihara, Osamu Onodera
Abnormal accumulation of TAR DNA-binding protein 43 (TDP-43) in the cytoplasm and its disappearance from the nucleus are pathological features of amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD) and are directly involved in the pathogenesis of these conditions. TDP-43 is an essential nuclear protein that readily aggregates in a concentration-dependent manner. Therefore, cells must strictly maintain an appropriate amount of nuclear TDP-43. In one relevant maintenance mechanism, TDP-43 binds to its pre-mRNA and promotes alternative splicing, resulting in mRNA degradation via nonsense-mediated mRNA decay...
2018: Frontiers in Neuroscience
Harshad Paithankar, Pankaj V Jadhav, Amit S Naglekar, Shilpy Sharma, Jeetender Chugh
TAR RNA binding protein (TRBP) is a double-stranded RNA binding protein involved in various biological processes like cell growth, development, death, etc. The protein exists as two isoforms TRBP2 and TRBP1. TRBP2 contains additional 21 amino acids at its N-terminus, which are proposed to be involved in its membrane localization, when compared to TRBP1. The resonance assignment (19-228) of the double-stranded RNA binding domains (dsRBD 1 and 2) of TRBP2 has been reported earlier. Here, we report 1 H, 13 C and 15 N resonance assignment for dsRBD1 of TRBP2 (1-105) containing the additional N-terminal residues...
February 14, 2018: Biomolecular NMR Assignments
Anne Vejux, Amira Namsi, Thomas Nury, Thibault Moreau, Gérard Lizard
Amyotrophic lateral sclerosis (ALS) is a non-demyelinating neurodegenerative disease in adults with motor disorders. Two forms exist: a sporadic form (90% of cases) and a family form due to mutations in more than 20 genes including the Superoxide dismutase 1, TAR DNA Binding Protein, Fused in Sarcoma, chromosome 9 open reading frame 72 and VAPB genes. The mechanisms associated with this pathology are beginning to be known: oxidative stress, glutamate excitotoxicity, protein aggregation, reticulum endoplasmic stress, neuroinflammation, alteration of RNA metabolism...
2018: Frontiers in Molecular Neuroscience
Federico G Usuelli, Riccardo D'Ambrosi, Luigi Manzi, Camilla Maccario, Cristian Indino
Total ankle replacement (TAR) is a valid option for the treatment of ankle osteoarthritis. The traditional surgical approach for TAR is the anterior approach. Recently, the lateral transfibular approach to the ankle has gained popularity since a new TAR implant was designed to be performed via this approach that results in an ideal visualization of the center of rotation of the ankle and curved resections that allow for sparing bone cuts. The aim of the present paper is to present our preoperative, operative, and postoperative protocols for the treatment of the osteoarthritis of the ankle with TAR via lateral approach...
January 24, 2018: Journal of Visualized Experiments: JoVE
Julie A LaBar, Robert W Nairn
A passive treatment system (PTS), including two parallel vertical flow bioreactors (VFBR), was constructed in 2008 for the treatment of unabated net-alkaline ferruginous mine drainage in the Tar Creek Superfund Site in northeastern Oklahoma. Water quality data collected since the PTS began operation indicate significant removal of trace metals in the VFBR. Results of a sequential extraction procedure (SEP) performed on substrate samples showed that the majority of Cd, Co, Fe, Ni, Pb, and Zn were retained in the refractory organic/sulfide fraction...
February 3, 2018: Chemosphere
Kamran Akhbari, Sepideh Karami, Zahra Saedi
In order to study the effects of solvent and ultrasonic irradiation on formation of [Tl(HTar)]n (1) and/or [Tl2(Tar)]n (2), [H2Tar = (+)-tartaric acid] supramolecular polymers, we designed some experiments and synthesized four samples of 1 under the reaction of H2Tar and TlNO3 by sonochemical process and as the bulk samples. Nanostructures of compounds 1 and 2 as the bulk samples could be synthesized without ultrasonic irradiation, too. In the presence of ultrasonic waves, with acetonitrile solvent, more discrete nanoparticles were obtained...
April 2018: Ultrasonics Sonochemistry
Jacopo Solari, Francois Anquez, Katharina M Scherer, Thomas S Shimizu
We describe two methods for high-resolution fluorescence imaging of the positioning and mobility of E. coli chemoreceptors fused to photoconvertible fluorescent proteins. Chemoreceptors such as Tar and Tsr are transmembrane proteins expressed at high levels (thousands of copies per cell). Together with their cognate cytosolic signaling proteins, they form clusters on the plasma membrane. Theoretical models imply that the size of these clusters is an important parameter for signaling, and recent PALM imaging has revealed a broad distribution of cluster sizes...
2018: Methods in Molecular Biology
Rahmi Yusuf, Robert J Lawrence, Lucy V Eke, Roger R Draheim
Aromatic tuning facilitates stimulus-independent modulation of receptor output. The methodology is based upon the affinity of amphipathic aromatic residues, namely Trp and Tyr, for the polar-hydrophobic interfaces found within biological membranes. Here, we describe the application of aromatic tuning within the aspartate chemoreceptor of Escherichia coli (Tar). We have also employed the method within other related proteins, such as sensor histidine kinases (SHKs), and therefore hope that other research groups find it useful to modulate signal output from their receptor of interest...
2018: Methods in Molecular Biology
Zhiqiang Wu, Wangcai Yang, Yaowu Li, Bolun Yang
In this work, the distributions and releasing properties of the primary volatile products during co-pyrolysis of low-rank coal and green algae (GA) has been studied using fixed-bed reactor with online mass spectrometry. Surface morphology of the char was described quantitatively by SEM combined with fractal theory. Different forms of synergistic effects existed from both the yields of products and composition of the main gaseous products. Positive synergistic effects from tar yield were observed under 25% of GA from 600 to 850 °C, indicating GA promoted the formation of tar...
February 2, 2018: Bioresource Technology
Halise Inci Gul, Cem Yamali, Hiroshi Sakagami, Andrea Angeli, Janis Leitans, Andris Kazaks, Kaspars Tars, Dilan Ozmen Ozgun, Claudiu T Supuran
In this study, new 4-[3-(aryl)-5-substitutedphenyl-4,5-dihydro-1H-pyrazole-1-yl]benzensulfonamides (19-36) were synthesized and evaluated their cytotoxic/anticancer and CA inhibitory effects. According to results obtained, the compounds 34 (4-[5-(2,3,4-trimethoxyphenyl)-3-(thiophen-2-yl)-4,5-dihydro-1H-pyrazole-1-yl] benzensulfonamide, Potency-Selectivity Expression (PSE) = 141) and 36 (4-[5-(3,4,5-trimethoxyphenyl)-3-(thiophen-2-yl)-4,5-dihydro-1H-pyrazole-1-yl]benzensulfonamide, PSE = 54.5) were found the leader anticancer compounds with the highest PSE values...
January 16, 2018: Bioorganic Chemistry
Michael A Marciano, Sini X Panicker, Garrett D Liddil, Danielle Lindgren, Kevin S Sweder
This study is the first to report the successful development of a method to extract opium poppy (Papaver somniferum L.) DNA from heroin samples. Determining of the source of an unknown heroin sample (forensic geosourcing) is vital to informing domestic and foreign policy related to counter-narcoterrorism. Current profiling methods focus on identifying process-related chemical impurities found in heroin samples. Changes to the geographically distinct processing methods may lead to difficulties in classifying and attributing heroin samples to a region/country...
February 7, 2018: Scientific Reports
(no author information available yet)
No abstract text is available yet for this article.
February 8, 2018: Journal of Dermatological Treatment
Xiong Zhang, Qingfeng Che, Xiang Cui, Zhiyu Wei, Xiaoyan Zhang, Yingquan Chen, Xianhua Wang, Hanping Chen
In order to overcome the shortcoming of batch production in the retort and improve the quality of three-state products, a moving bed as pyrolysis furnace and torrefaction pretreatment were both used in a demonstration of biomass pyrolytic polygeneration. The bench and demonstration scale experiments were both investigated in this work. The results show that when the pyrolysis temperature between 550 °C and 750 °C, it can not only maintain the relative stability of the tri-state products yield, but also guarantee the quality...
February 2, 2018: Bioresource Technology
Richard deShazo, McKenzie Johnson, Ike Eriator, Kathryn Rodenmeyer
Epidemics of opioid use are old news in the United States, but an epidemic that kills over 200,000 Americans is not. A multiplicity of intertwined factors have brought us to this place. From 30,000 feet, it is the story of good intentions gone bad, a drug industry gone rogue, and government watch dog agencies gone to sleep. At ground level, it is the story of physicians unfamiliar with addictive drugs and drug addiction, new long acting opioids deceptively marketed, cheap black tar heroin, encouragement to use opioids for chronic non-cancer pain by professional organizations with conflicts of interest and without science, a culture intolerant to pain and tolerant to drug use, and the greedy response of the pharmaceutical industry and drug cartels to an expanding market opportunity...
January 31, 2018: American Journal of Medicine
Luigi Manzi, Jorge Hugo Villafañe, Cristian Indino, Jacopo Tamini, Pedro Berjano, Federico Giuseppe Usuelli
BACKGROUND: The purpose of this study was to investigate the test-retest reliability of the Phi angle in patients undergoing total ankle replacement (TAR) for end stage ankle osteoarthritis (OA) to assess the rotational alignment of the talar component. METHODS: Retrospective observational cross-sectional study of prospectively collected data. Post-operative anteroposterior radiographs of the foot of 170 patients who underwent TAR for the ankle OA were evaluated...
November 8, 2017: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
Federico Giuseppe Usuelli, Cristian Indino, Camilla Maccario, Luigi Manzi, Federico Maria Liuni, Ettore Vulcano
BACKGROUND: Total ankle replacement (TAR) represents an alternative to fusion for the treatment of end-stage ankle osteoarthritis. The aim of the present study was to retrospectively assess the frequency of infections between TARs with anterior and lateral transfibular approach at 12-months follow-up. METHODS: 81 TARs through an anterior approach and 69 TARs through a lateral approach were performed between May 2011 and July 2015. We compared surgical time and tourniquet time, as well as superficial and deep infections frequency during the first 12 postoperative months...
August 4, 2017: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
Thomas W Wainwright, Tikki Immins, Johannes H A Antonis, Heath Taylor, Robert G Middleton
BACKGROUND: Enhanced Recovery After Surgery (ERAS) has been successfully adopted across a range of procedures. This study explores whether there is scope to improve length of stay (LOS) for total ankle replacement surgery (TAR) in the UK by implementing ERAS pathways. METHODS: Hospital Episode Statistics (HES) data (April 2015/March 2016) on LOS for TAR were analysed. A literature search was then carried out to examine whether there were any publications on outpatient TAR and/or the use of ERAS protocols...
December 21, 2017: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
Sonam Parakh, Cyril J Jagaraj, Marta Vidal, Audrey M G Ragagnin, Emma R Perri, Anna Konopka, Reka Toth, Jasmin Galper, Ian P Blair, Colleen J Thomas, Adam K Walker, Shu Yang, Damian M Spencer, Julie D Atkin
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder and mutations in superoxide dismutase1 (SOD1) account for 20% of familial ALS cases. The aetiology of ALS remains unclear, but protein misfolding, endoplasmic reticulum (ER) stress and neuronal apoptosis are implicated. We previously established that protein disulphide isomerase (PDIA1) is protective against ER stress and apoptosis in neuronal cells expressing mutant SOD1, recently mutations in PDIA1 and related PDI family member endoplasmic reticulum protein 57 (ERp57/PDIA), were associated with ALS...
February 1, 2018: Human Molecular Genetics
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