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https://www.readbyqxmd.com/read/27913419/benzene-degradation-by-variovorax-sp-within-a-coal-tar-contaminated-groundwater-microbial-community
#1
Kevin M Posman, Christopher M DeRito, Eugene L Madsen
: Investigations of environmental microbial communities are crucial for the discovery of populations capable of degrading hazardous compounds and may lead to improved bioremediation strategies. The goal of this study was to identify microorganisms responsible for aerobic benzene degradation in coal-tar contaminated groundwater. Benzene degradation was monitored in laboratory incubations of well waters using gas chromatography mass spectrometry (GC/MS). Stable isotope probing (SIP) experiments using (13)C-benzene allowed us to obtain (13)C-labled community DNA; from this, 16S rRNA clone libraries identified γ- and β-Proteobacteria as the active benzene metabolizing microbial populations...
December 2, 2016: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/27906999/identification-geochemical-characterisation-and-significance-of-bitumen-among-the-grave-goods-of-the-7th-century-mound-1-ship-burial-at-sutton-hoo-suffolk-uk
#2
Pauline Burger, Rebecca J Stacey, Stephen A Bowden, Marei Hacke, John Parnell
The 7th century ship-burial at Sutton Hoo is famous for the spectacular treasure discovered when it was first excavated in 1939. The finds include gold and garnet jewellery, silverware, coins and ceremonial armour of broad geographical provenance which make a vital contribution to understanding the political landscape of early medieval Northern Europe. Fragments of black organic material found scattered within the burial were originally identified as 'Stockholm Tar' and linked to waterproofing and maintenance of the ship...
2016: PloS One
https://www.readbyqxmd.com/read/27905059/exposure-to-secondhand-smoke-impairs-fracture-healing-in-rats
#3
Hildemberg A R Santiago, Ariane Zamarioli, Manoel D Sousa Neto, Jose B Volpon
BACKGROUND: Nonsmokers may be affected by environmental tobacco smoke (secondhand smoke), but the effects of such exposure on fracture healing have not been well studied. QUESTIONS/PURPOSES: To explore the possible effects of passive inhalation of tobacco smoke on the healing of a diaphyseal fracture in femurs of rats. We hypothesized that secondhand exposure to tobacco smoke adversely affects fracture healing. METHODS: A mid-diaphyseal fracture was created in the femur of 41 female Wistar rats and fixed with an intramedullary metallic pin; 14 rats were excluded (nine for inadequate fractures and five for K wire extrusion)...
November 30, 2016: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/27890430/tar-dna-binding-protein-43-inhibits-inflammatory-response-and-protects-chondrocyte-function-by-modulating-rack1-expression-in-osteoarthritis
#4
Yongming Huang, Qiming Huang, Haitao Su, Xiujun Mai, Enhui Feng, Zhenwu Cao, Xiuyun Zeng
BACKGROUND: TAR DNA-binding protein-43 (TDP-43, transactive response DNA binding protein 43kDa) accumulates in the cytoplasm of affected neurons and glia, as large inclusions of stress granules (SGs). However, the mechanism of TDP-43 interaction with the target genes and its specific role in osteoarthritis (OA) progression is still unknown. The goal of this study was to identify the role of TDP-43 in OA progression by modulating its target genes. METHODS: MSCs were transfected with TDP-43 gene lentivirus...
November 24, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27885598/identification-of-ligand-receptor-interactions-ligand-molecular-arrays-spr-and-nmr-methodologies
#5
Christopher J Day, Lauren E Hartley-Tassell, Victoria Korolik
Despite many years of research into bacterial chemotaxis, the only well characterized system to date is that of E. coli. Even for E. coli, the direct ligand binding had been fully characterized only for aspartate and serene receptors Tar and Tsr. In 30 years since, no other direct receptor-ligand interaction had been described for bacteria, until the characterization of the C. jejuni aspartate and multiligand receptors (Hartley-Tassell et al. Mol Microbiol 75:710-730, 2010). While signal transduction components of many sensory pathways have now been characterized, ligand-receptor interactions remain elusive due to paucity of high-throughput screening methods...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27883276/microporous-organic-polymers-based-on-hyper-cross-linked-coal-tar-preparation-and-application-for-gas-adsorption
#6
Hui Gao, Lei Ding, Hua Bai, Lei Li
Hyper-cross-linked polymers (HCPs) are promising materials for gas capture and storage, but the high cost and complicated preparation limit their practical application. In this paper, a novel type of HCPs (CTHPs) is synthesized via one-step mild Friedel-Crafts reaction with low-cost coal tar as the starting material. Chloroform is utilized as both the solvent and crosslinker, to generate three-dimensional crosslinked network with abundant micropores. The maximum BET surface area of the prepared CTHPs can reach up to 929 m2 g-1...
November 24, 2016: ChemSusChem
https://www.readbyqxmd.com/read/27883232/primary-sources-and-toxicity-of-pahs-in-milwaukee-area-streambed-sediment
#7
Austin K Baldwin, Steven R Corsi, Michelle A Lutz, Christopher G Ingersoll, Rebecca Dorman, Christopher Magruder, Matthew Magruder
High concentrations of polycyclic aromatic hydrocarbons (PAHs) in streams can be a significant stressor to aquatic organisms. To understand the likely sources and toxicity of PAHs in Milwaukee-area streams, streambed sediment samples from 40 sites and parking lot dust samples from 6 sites were analyzed for 38 parent PAHs and 25 alkylated PAHs. Diagnostic ratios, profile correlations, principal components analysis, source-receptor modeling, and mass fractions analysis were used to identify potential PAH sources to streambed sediment samples, and land-use analysis was used to relate streambed sediment PAH concentrations to different urban-related land uses...
November 24, 2016: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/27865050/nmr-spectroscopic-assignment-of-backbone-and-side-chain-protons-in-fully-protonated-proteins-microcrystals-sedimented-assemblies-and-amyloid-fibrils
#8
Jan Stanek, Loren B Andreas, Kristaps Jaudzems, Diane Cala, Daniela Lalli, Andrea Bertarello, Tobias Schubeis, Inara Akopjana, Svetlana Kotelovica, Kaspars Tars, Andrea Pica, Serena Leone, Delia Picone, Zhi-Qiang Xu, Nicholas E Dixon, Denis Martinez, Mélanie Berbon, Nadia El Mammeri, Abdelmajid Noubhani, Sven Saupe, Birgit Habenstein, Antoine Loquet, Guido Pintacuda
We demonstrate sensitive detection of alpha protons of fully protonated proteins by solid-state NMR spectroscopy with 100-111 kHz magic-angle spinning (MAS). The excellent resolution in the Cα-Hα plane is demonstrated for 5 proteins, including microcrystals, a sedimented complex, a capsid and amyloid fibrils. A set of 3D spectra based on a Cα-Hα detection block was developed and applied for the sequence-specific backbone and aliphatic side-chain resonance assignment using only 500 μg of sample. These developments accelerate structural studies of biomolecular assemblies available in submilligram quantities without the need of protein deuteration...
November 16, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27858273/comparison-of-the-phytoremediation-potentials-of-medicago-falcata-l-and-medicago-sativa-l-in-aged-oil-sludge-contaminated-soil
#9
Leonid Panchenko, Anna Muratova, Olga Turkovskaya
Thirteen-year monitoring of the vegetation growing in the industrial and adjacent areas of an oil refinery showed the prevalence of yellow medick (Medicago falcata L.) over other plant species, including alfalfa (Medicago sativa L.). A comparative field study of the two Medicago species established that yellow medick and alfalfa exhibited similar resistance to soil petroleum hydrocarbons and that the pollutant concentration in their rhizosphere was 30% lower than that in the surrounding bulk soil. In laboratory pot experiments, yellow medick reduced the contaminant content by 18% owing to the degradation of the major heavy oil fractions, such as paraffins, naphthenes, and alcohol and benzene tars; and it was more successful than alfalfa...
November 17, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27858113/a-framework-for-the-use-of-single-chemical-transcriptomics-data-in-predicting-the-hazards-associated-with-complex-mixtures-of-polycyclic-aromatic-hydrocarbons
#10
Sarah Labib, Andrew Williams, Byron Kuo, Carole L Yauk, Paul A White, Sabina Halappanavar
The assumption of additivity applied in the risk assessment of environmental mixtures containing carcinogenic polycyclic aromatic hydrocarbons (PAHs) was investigated using transcriptomics. MutaTMMouse were gavaged for 28 days with three doses of eight individual PAHs, two defined mixtures of PAHs, or coal tar, an environmentally ubiquitous complex mixture of PAHs. Microarrays were used to identify differentially expressed genes (DEGs) in lung tissue collected 3 days post-exposure. Cancer-related pathways perturbed by the individual or mixtures of PAHs were identified, and dose-response modeling of the DEGs was conducted to calculate gene/pathway benchmark doses (BMDs)...
November 17, 2016: Archives of Toxicology
https://www.readbyqxmd.com/read/27856940/reducing-nicotine-exposure-results-in-weight-gain-in-smokers-randomised-to-very-low-nicotine-content-cigarettes
#11
Laura E Rupprecht, Joseph S Koopmeiners, Sarah S Dermody, Jason A Oliver, Mustafa al'Absi, Neal L Benowitz, Rachel Denlinger-Apte, David J Drobes, Dorothy Hatsukami, F Joseph McClernon, Lauren R Pacek, Tracy T Smith, Alan F Sved, Jennifer Tidey, Ryan Vandrey, Eric C Donny
BACKGROUND: The Food and Drug Administration can reduce the nicotine content in cigarettes to very low levels. This potential regulatory action is hypothesised to improve public health by reducing smoking, but may have unintended consequences related to weight gain. METHODS: Weight gain was evaluated from a double-blind, parallel, randomised clinical trial of 839 participants assigned to smoke 1 of 6 investigational cigarettes with nicotine content ranging from 0...
November 17, 2016: Tobacco Control
https://www.readbyqxmd.com/read/27855774/total-ankle-replacement-through-a-lateral-approach-surgical-tips
#12
Federico Giuseppe Usuelli, Cristian Indino, Camilla Maccario, Luigi Manzi, Vincenzo Salini
PURPOSE: Recently, the Zimmer Trabecular Metal Total Ankle Replacement (Zimmer TM TAR) was developed to be used through a lateral transfibular approach. The purpose of this paper is to describe the surgical technique and early outcomes of the TAR via the lateral approach using the Zimmer TM TARs. METHODS: Sixty-seven patients underwent primary TAR using the Zimmer TM TAR between May 2013 and May 2015. Patients were clinically evaluated preoperatively and postoperatively at six and twelve months and annually using the American Orthopaedic Foot & Ankle Society (AOFAS) ankle and hindfoot scores, visual analogue scale (VAS) pain score, and the Short Form Health Survey (SF-12) questionnaire...
2016: SICOT-J
https://www.readbyqxmd.com/read/27855637/protein-ligand-specific-binding-residue-predictions-by-an-ensemble-classifier
#13
Xiuzhen Hu, Kai Wang, Qiwen Dong
BACKGROUND: Prediction of ligand binding sites is important to elucidate protein functions and is helpful for drug design. Although much progress has been made, many challenges still need to be addressed. Prediction methods need to be carefully developed to account for chemical and structural differences between ligands. RESULTS: In this study, we present ligand-specific methods to predict the binding sites of protein-ligand interactions. First, a sequence-based method is proposed that only extracts features from protein sequence information, including evolutionary conservation scores and predicted structure properties...
November 17, 2016: BMC Bioinformatics
https://www.readbyqxmd.com/read/27844446/severe-infliximab-induced-alopecia-and-scalp-psoriasis-in-a-woman-with-crohn-s-disease-dramatic-improvement-after-drug-discontinuation-and-treatment-with-adjuvant-systemic-and-topical-therapies
#14
Jeremy Udkoff, Philip R Cohen
Scalp psoriasis with alopecia is a rare cutaneous reaction to tumor necrosis factor alpha antagonists. This reaction often reverses with discontinuation of the offending drug and initiation of topical treatments; however, irreversible hair loss may occur if a scarring alopecia develops. We describe a woman with Crohn's disease who developed scalp psoriasis and alopecia secondary to infliximab. She had a remarkable recovery after discontinuation of infliximab and treatment with oral minocycline and topical therapy: mineral oil under occlusion, betamethasone lotion, and sequential coal tar, salicylic acid, and ketoconazole shampoos each day...
November 14, 2016: Dermatology and Therapy
https://www.readbyqxmd.com/read/27843439/biosurfactants-promising-molecules-for-petroleum-biotechnology-advances
#15
REVIEW
Darne G De Almeida, Rita de Cássia F Soares Da Silva, Juliana M Luna, Raquel D Rufino, Valdemir A Santos, Ibrahim M Banat, Leonie A Sarubbo
The growing global demand for sustainable technologies that improves the efficiency of petrochemical processes in the oil industry has driven advances in petroleum biotechnology in recent years. Petroleum industry uses substantial amounts of petrochemical-based synthetic surfactants in its activities as mobilizing agents to increase the availability or recovery of hydrocarbons as well as many other applications related to extraction, treatment, cleaning, and transportation. However, biosurfactants have several potential applications for use across the oil processing chain and in the formulations of petrochemical products such as emulsifying/demulsifying agents, anticorrosive, biocides for sulfate-reducing bacteria, fuel formulation, extraction of bitumen from tar sands, and many other innovative applications...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27834214/motor-neuron-disease-tdp-43-pathology-and-memory-deficits-in-mice-expressing-als-ftd-linked-ubqln2-mutations
#16
Nhat T T Le, Lydia Chang, Irina Kovlyagina, Polymnia Georgiou, Nathaniel Safren, Kerstin E Braunstein, Mark D Kvarta, Adam M Van Dyke, Tara A LeGates, Thomas Philips, Brett M Morrison, Scott M Thompson, Adam C Puche, Todd D Gould, Jeffrey D Rothstein, Philip C Wong, Mervyn J Monteiro
Missense mutations in ubiquilin 2 (UBQLN2) cause ALS with frontotemporal dementia (ALS-FTD). Animal models of ALS are useful for understanding the mechanisms of pathogenesis and for preclinical investigations. However, previous rodent models carrying UBQLN2 mutations failed to manifest any sign of motor neuron disease. Here, we show that lines of mice expressing either the ALS-FTD-linked P497S or P506T UBQLN2 mutations have cognitive deficits, shortened lifespans, and develop motor neuron disease, mimicking the human disease...
November 22, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27832389/efficacy-of-human-immunodeficiency-virus-sexually-transmitted-infection-prevention-interventions-targeting-female-entertainment-workers-a-systematic-review-and-meta-analysis
#17
REVIEW
Raymond Boon Tar Lim, Dede Kam Tyng Tham, Olive N Y Cheung, Mee Lian Wong
Female entertainment workers (FEWs) working in karaoke lounges, bars, pubs, nightclubs, discotheques, dance halls, massage parlours, restaurants (as hostesses or singers) and beer gardens are at high risk for human immunodeficiency virus (HIV)/sexually transmitted infection (STI). The aim of the systematic review and meta-analysis is to evaluate the efficacy of HIV/STI intervention programmes targeting FEWs. Among the 14 included studies, majority were in Asia and targeted native FEWs. Most studies were quasi-experimental and the overall quality was relatively low...
November 10, 2016: AIDS and Behavior
https://www.readbyqxmd.com/read/27829245/the-true-story-and-advantages-of-rna-phage-capsids-as-nanotools
#18
Paul Pumpens, Regina Renhofa, Andris Dishlers, Tatjana Kozlovska, Velta Ose, Peter Pushko, Kaspars Tars, Elmars Grens, Martin F Bachmann
RNA phages are often used as prototypes for modern recombinant virus-like particle (VLP) technologies. Icosahedral RNA phage VLPs can be formed from coat proteins (CPs) and are efficiently produced in bacteria and yeast. Both genetic fusion and chemical coupling have been successfully used for the production of numerous chimeras based on RNA phage VLPs. In this review, we describe advances in RNA phage VLP technology along with the history of the Leviviridae family, including its taxonomical organization, genomic structure, and important role in the development of molecular biology...
November 10, 2016: Intervirology
https://www.readbyqxmd.com/read/27821454/sustained-nitric-oxide-releasing-nanoparticles-interfere-with-methicillin-resistant-staphylococcus-aureus-adhesion-and-biofilm-formation-in-a-rat-central-venous-catheter-model
#19
Mircea Radu Mihu, Vitor Cabral, Rodney Pattabhi, Moses T Tar, Kelvin P Davies, Adam J Friedman, Luis R Martinez, Joshua D Nosanchuk
Staphylococcus aureus is frequently isolated in the setting of infections of indwelling medical devices, which are mediated by the microbe's ability to form biofilms on a variety of surfaces. Biofilm-embedded bacteria are more resistant to antimicrobial agents than their planktonic counterparts and often cause chronic infections and sepsis, particularly in patients with prolonged hospitalizations. In this study, we demonstrate that sustained nitric oxide-releasing nanoparticles (NO-np) interfere with S. aureus adhesion and prevent biofilm formation on a rat central venous catheters (CVCs) model of infection...
November 7, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27805476/the-acute-exercise-induced-inflammatory-response-a-comparison-of-young-adult-smokers-and-nonsmokers
#20
Tegan E Kastelein, Cheyne E Donges, Amy E Mendham, Rob Duffield
PURPOSE: This study examined postexercise inflammatory and leukocyte responses in smokers and nonsmokers, as well as the effects of cigarette smoking on the acute postexercise inflammatory and leukocyte response in habitual smokers. METHOD: Eleven recreationally active male smokers and 11 nonsmokers matched for age and aerobic fitness were familiarized and underwent baseline fitness testing. Participants then completed 40 min of cycling at 50% peak aerobic workload...
November 2, 2016: Research Quarterly for Exercise and Sport
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