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https://www.readbyqxmd.com/read/29049830/acute-debakey-type-i-aortic-dissection-without-intimal-tear-in-the-arch-is-total-arch-replacement-the-right-choice
#1
Andrea Colli, Massimiliano Carrozzini, Annalisa Francescato, Marco Galuppo, Marina Comisso, Francesca Toto, Dario Gregori, Gino Gerosa
OBJECTIVES: Surgical management of acute DeBakey Type I aortic dissection without intimal tear in the aortic arch is controversial. This study compared short- and long-term outcomes of total arch replacement (TAR) versus limited ascending aorta/hemiarch replacement (no-TAR) in a consecutive series of patients. METHODS: Between January 1998 and December 2015, 220 consecutive patients were operated for DeBakey Type I acute aortic dissection; 135 cases did not exhibit an intimal entry tear in the aortic arch and were subsequently selected to comprise the primary study cohort...
July 31, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29045748/conserved-asymmetry-underpins-homodimerization-of-dicer-associated-double-stranded-rna-binding-proteins
#2
Alex Heyam, Claire E Coupland, Clément Dégut, Ruth A Haley, Nicola J Baxter, Leonhard Jakob, Pedro M Aguiar, Gunter Meister, Michael P Williamson, Dimitris Lagos, Michael J Plevin
Double-stranded RNA-binding domains (dsRBDs) are commonly found in modular proteins that interact with RNA. Two varieties of dsRBD exist: canonical Type A dsRBDs interact with dsRNA, while non-canonical Type B dsRBDs lack RNA-binding residues and instead interact with other proteins. In higher eukaryotes, the microRNA biogenesis enzyme Dicer forms a 1:1 association with a dsRNA-binding protein (dsRBP). Human Dicer associates with HIV TAR RNA-binding protein (TRBP) or protein activator of PKR (PACT), while Drosophila Dicer-1 associates with Loquacious (Loqs)...
October 17, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29042117/restoring-masticatory-function-in-a-patient-with-severe-microstomia-using-rapid-prototyped-mesh-and-a-custom-made-hinge-and-swing-lock-prosthesis
#3
Ibrahim Tulunoglu, Meng Huan Lee, Mohammed Louay Taifur, Ozlem Tulunoglu
This clinical report describes the use of rapid prototyped mesh in a complete swing-lock prosthesis to restore masticatory function in an edentulous patient with severe microstomia and perioral scar tissue after an industrial hot tar accident.
October 14, 2017: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/29040648/molecular-basis-for-asymmetry-sensing-of-sirnas-by-the-drosophila-loqs-pd-dcr-2-complex-in-rna-interference
#4
Jan-Niklas Tants, Stephanie Fesser, Thomas Kern, Ralf Stehle, Arie Geerlof, Christoph Wunderlich, Michael Juen, Christoph Hartlmüller, Romy Böttcher, Stefan Kunzelmann, Oliver Lange, Christoph Kreutz, Klaus Förstemann, Michael Sattler
RNA interference defends against RNA viruses and retro-elements within an organism's genome. It is triggered by duplex siRNAs, of which one strand is selected to confer sequence-specificity to the RNA induced silencing complex (RISC). In Drosophila, Dicer-2 (Dcr-2) and the double-stranded RNA binding domain (dsRBD) protein R2D2 form the RISC loading complex (RLC) and select one strand of exogenous siRNAs according to the relative thermodynamic stability of base-pairing at either end. Through genome editing we demonstrate that Loqs-PD, the Drosophila homolog of human TAR RNA binding protein (TRBP) and a paralog of R2D2, forms an alternative RLC with Dcr-2 that is required for strand choice of endogenous siRNAs in S2 cells...
October 13, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29037990/roles-for-the-vcp-co-factors-npl4-and-ufd1-in-neuronal-function-in-drosophila-melanogaster
#5
Dwayne J Byrne, Mark J Harmon, Jeremy C Simpson, Craig Blackstone, Niamh C O'Sullivan
The VCP-Ufd1-Npl4 complex regulates proteasomal processing within cells by delivering ubiquitinated proteins to the proteasome for degradation. Mutations in VCP are associated with two neurodegenerative diseases, amyotrophic lateral sclerosis (ALS) and inclusion body myopathy with Paget's disease of the bone and frontotemporal dementia (IBMPFD), and extensive study has revealed crucial functions of VCP within neurons. By contrast, little is known about the functions of Npl4 or Ufd1 in vivo. Using neuronal-specific knockdown of Npl4 or Ufd1 in Drosophila melanogaster, we infer that Npl4 contributes to microtubule organization within developing motor neurons...
September 21, 2017: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/29037489/latent-hiv-1-tar-regulates-7sk-responsive-p-tefb-target-genes-and-targets-cellular-immune-responses-in-the-absence-of-tat
#6
Sebastian Eilebrecht, Bernd-Joachim Benecke, Arndt G Benecke
The transactivating response element (TAR) structure of the nascent HIV-1 transcript is critically involved in the recruitment of inactive positive transcription elongation factor b (P-TEFb) to the promoter proximal paused RNA polymerase II. The viral transactivator Tat is responsible for subsequent P-TEFb activation in order to start efficient viral transcription elongation. In the absence of the viral transactivator of transcription (Tat), e.g., during latency or in early stages of HIV transcription, TAR mediates an interaction of P-TEFb with its inhibitor hexamethylene bis-acetamide-inducible proteins 1 (HEXIM1), keeping P-TEFb in its inactive form...
October 13, 2017: Genomics, Proteomics & Bioinformatics
https://www.readbyqxmd.com/read/29035727/co-pyrolysis-characteristics-and-kinetic-analysis-of-organic-food-waste-and-plastic
#7
Yijing Tang, Qunxing Huang, Kai Sun, Yong Chi, Jianhua Yan
In this work, typical organic food waste (soybean protein (SP)) and typical chlorine enriched plastic waste (polyvinyl chloride (PVC)) were chosen as principal MSW components and their interaction during co-pyrolysis was investigated. Results indicate that the interaction accelerated the reaction during co-pyrolysis. The activation energies needed were 2-13% lower for the decomposition of mixture compared with linear calculation while the maximum reaction rates were 12-16% higher than calculation. In the fixed-bed experiments, interaction was observed to reduce the yield of tar by 2-69% and promote the yield of char by 13-39% compared with linear calculation...
October 3, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/29033477/is-lhasa-tibetan-sign-language-emerging-endangered-or-both
#8
Theresia Hofer
This article offers the first overview of the recent emergence of Tibetan Sign Language (TibSL) in Lhasa, capital of the Tibet Autonomous Region (TAR), China. Drawing on short anthropological fieldwork, in 2007 and 2014, with people and organisations involved in the formalisation and promotion of TibSL, the author discusses her findings within the nine-fold UNESCO model for assessing linguistic vitality and endangerment. She follows the adaptation of this model to assess signed languages by the Institute of Sign Languages and Deaf Studies (iSLanDS) at the University of Central Lancashire...
May 24, 2017: International Journal of the Sociology of Language
https://www.readbyqxmd.com/read/29031165/characterization-and-morphological-analysis-of-individual-aerosol-of-pm10-in-urban-area-of-lucknow-india
#9
Sushil Kumar Bharti, Dhananjay Kumar, Sangeeta Anand, Poonam, Shymal Chandra Barman, Narendra Kumar
Airborne particulate matters were collected during the period of October 2015 to September 2016 in Lucknow at different sampling sites. The annual mean concentration of particulate matter was found to be relatively higher than the limits prescribed by National ambient air quality standards (NAAQS), United State Environmental Protection Agency (USEPA) and World Health Organization (WHO). Particulate matters were studied for morphological analysis, elemental composition and functional group variability with the help of Scanning Electron Microscope-Energy Dispersive Spectroscopy (SEM-EDS) followed by Fourier Transform Infrared spectroscopy (FTIR)...
September 14, 2017: Micron: the International Research and Review Journal for Microscopy
https://www.readbyqxmd.com/read/28992834/prevalence-of-cardiac-arrhythmias-in-asian-patients-with-obstructive-sleep-apnea-a-singapore-sleep-center-experience
#10
Wei Li Neo, Adele C W Ng, Mahalakshmi Rangabashyam, Ying Hao, Kah Leng Ho, Siti Raudha Binte Senin, Song Tar Toh
STUDY OBJECTIVES: Obstructive sleep apnea (OSA) is associated with increased cardiovascular morbidity and mortality. Cardiac arrhythmias are common in patients with OSA. However, the prevalence and significance of cardiac arrhythmias in Asian patients with OSA are not well studied. The aim of this study is to determine the prevalence of cardiac arrhythmias in patients with OSA in Singapore and to evaluate possible factors that may predispose patients with OSA to arrhythmias. METHODS: A retrospective study of 2,019 patients was carried out from January 2011 to December 2012 at a sleep center in a tertiary medical center...
October 4, 2017: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/28989973/cloning-assembly-and-modification-of-the-primary-human-cytomegalovirus-isolate-toledo-by-yeast-based-transformation-associated-recombination
#11
Sanjay Vashee, Timothy B Stockwell, Nina Alperovich, Evgeniya A Denisova, Daniel G Gibson, Kyle C Cady, Kristofer Miller, Krishna Kannan, Daniel Malouli, Lindsey B Crawford, Alexander A Voorhies, Eric Bruening, Patrizia Caposio, Klaus Früh
Genetic engineering of cytomegalovirus (CMV) currently relies on generating a bacterial artificial chromosome (BAC) by introducing a bacterial origin of replication into the viral genome using in vivo recombination in virally infected tissue culture cells. However, this process is inefficient, results in adaptive mutations, and involves deletion of viral genes to avoid oversized genomes when inserting the BAC cassette. Moreover, BAC technology does not permit the simultaneous manipulation of multiple genome loci and cannot be used to construct synthetic genomes...
September 2017: MSphere
https://www.readbyqxmd.com/read/28988034/the-physical-forces-mediating-self-association-and-phase-separation-in-the-c-terminal-domain-of-tdp-43
#12
Hao-Ru Li, Tsai-Chen Chen, Chih-Lun Hsiao, Lin Shi, Chi-Yuan Chou, Jie-Rong Huang
The TAR DNA-binding protein of 43kDa (TDP-43) has been identified as the main component of amyotrophic lateral sclerosis (ALS) cytoplasmic inclusions. The link between this proteinopathy and TDP-43's intrinsically disordered C-terminal domain is well known, but recently also, this domain has been shown to be involved in the formation of the membraneless organelles that mediate TDP-43's functions. The mechanisms that underpin the liquid-liquid phase separation (LLPS) of these membraneless organelles undergo remain elusive...
October 4, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28987808/landscape-epidemiology-in-urban-environments-the-example-of-rodent-borne-trypanosoma-in-niamey-niger
#13
J-P Rossi, I Kadaouré, M Godefroid, G Dobigny
Trypanosomes are protozoan parasites found worldwide, infecting humans and animals. In the past decade, the number of reports on atypical human cases due to Trypanosoma lewisi or T. lewisi-like has increased urging to investigate the multiple factors driving the disease dynamics, particularly in cities where rodents and humans co-exist at high densities. In the present survey, we used a species distribution model, Maxent, to assess the spatial pattern of Trypanosoma-positive rodents in the city of Niamey. The explanatory variables were landscape metrics describing urban landscape composition and physiognomy computed from 8 land-cover classes...
October 4, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28987178/concepts-and-classification-of-neurodegenerative-diseases
#14
Gabor G Kovacs
Neurodegenerative diseases are disorders characterized by progressive loss of neurons associated with deposition of proteins showing altered physicochemical properties in the brain and in peripheral organs. Molecular classification of neurodegenerative disease is protein-based. This emphasizes the role of protein-processing systems in the pathogenesis. The most frequent proteins involved in the pathogenesis of neurodegenerative diseases are amyloid-β, prion protein, tau, α-synuclein, TAR-DNA-binding protein 43kDa, and fused-in sarcoma protein...
2017: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/28984110/neuronal-cytoplasmic-inclusions-in-tau-tdp-43-and-fus-molecular-subtypes-of-frontotemporal-lobar-degeneration-share-similar-spatial-patterns
#15
Richard A Armstrong
The 'prion-like' transfer of pathogenic proteins may play a role in the pathogenesis of frontotemporal lobar degeneration (FTLD). Propagation of such proteins along anatomical pathways may give rise to specific spatial patterns of the 'signature' neuronal cytoplasmic inclusions (NCI) characteristic of these disorders. Hence, the spatial patterns of the NCI were compared in three molecular subtypes of FTLD: (1) two variants of FTLD-tau, viz. cortico-basal degeneration (CBD) and Pick's disease (PiD), (2) FTLD with transactive response (TAR) DNA-binding protein 43(TDP-43)-immunoreactive inclusions (FTLD-TDP), and (3) FTLD with 'fused in sarcoma' (FUS)-immunoreactive inclusions (FTLD-FUS)...
2017: Folia Neuropathologica
https://www.readbyqxmd.com/read/28960539/target-highlights-from-the-first-post-psi-casp-experiment-casp12-may-august-2016
#16
Andriy Kryshtafovych, Reinhard Albrecht, Arnaud Baslé, Pedro Bule, Alessandro T Caputo, Ana Luisa Carvalho, Kinlin L Chao, Ron Diskin, Krzysztof Fidelis, Carlos M G A Fontes, Folmer Fredslund, Harry J Gilbert, Celia W Goulding, Marcus D Hartmann, Christopher S Hayes, Osnat Herzberg, Johan C Hill, Andrzej Joachimiak, Gert-Wieland Kohring, Roman I Koning, Leila Lo Leggio, Marco Mangiagalli, Karolina Michalska, John Moult, Shabir Najmudin, Marco Nardini, Valentina Nardone, Didier Ndeh, Thanh H Nguyen, Guido Pintacuda, Sandra Postel, Mark J van Raaij, Pietro Roversi, Amir Shimon, Abhimanyu K Singh, Eric J Sundberg, Kaspars Tars, Nicole Zitzmann, Torsten Schwede
The functional and biological significance of the selected CASP12 targets are described by the authors of the structures. The crystallographers discuss the most interesting structural features of the target proteins and assess whether these features were correctly reproduced in the predictions submitted to the CASP12 experiment. This article is protected by copyright. All rights reserved.
September 28, 2017: Proteins
https://www.readbyqxmd.com/read/28956666/word-initial-tap-trill-clusters-hungarian
#17
Éva Tar
This study investigates the developmental patterns of acquisition of word-initial (WI) /r/-clusters in children speaking Hungarian, typically developing (TD) or with protracted phonological development (PPD). Comparison data were also analysed for WI singleton /r/ and /l/. Participants were 191 children (aged 3;0-5;11) divided into three age groups (3, 4, 5 years), and further subdivided into TD and PPD subgroups on the basis of Whole Word Match scores (WWM). Acoustic analyses of perceptually accurate clusters were conducted to investigate epenthesis...
September 28, 2017: Clinical Linguistics & Phonetics
https://www.readbyqxmd.com/read/28956659/word-initial-r-clusters-in-icelandic-speaking-children-with-protracted-versus-typical-phonological-development
#18
Thóra Másdóttir
Rhotics are generally acquired late across languages (Jiménez, 1987; Tar, 2006; Blumenthal and Lundeborg, 2014). Prior research suggests some possible differences in acquisition across languages, however (Másdóttir and Stokes, 2016). The current study set out to examine acquisition of /r/ in Icelandic, focusing primarily on match (accuracy) and mismatch data for word-initial (WI) /r/-clusters, but also comparing /r/-clusters with WI singleton /r/ and /l/ plus /l/-clusters. Single-word data were collected for 27 Icelandic-speaking preschoolers with protracted phonological development (PPD) and compared with data from age- and gender-matched typically developing peers...
September 28, 2017: Clinical Linguistics & Phonetics
https://www.readbyqxmd.com/read/28955000/levetiracetam-improves-symptoms-of-multiple-chemical-sensitivity-case-report
#19
Yosuke Kakisaka, Kazutaka Jin, Mayu Fujikawa, Yu Kitazawa, Kazuhiro Kato, Nobukazu Nakasato
Multiple chemical sensitivity (MCS) is a disorder of unknown etiology with no effective treatment. Many clinicians accept that a diagnosis of somatic symptoms disorder (SSD) is an appropriate diagnostic category for MCS. We found that administration of levetiracetam improved recurrent symptoms of MCS in a patient. A 23-year-old female presented with recurrent multiple symptoms of musculoskeletal, airway or mucous membrane, heart/chest-related, gastrointestinal, cognitive, affective, neuromuscular, head-related, and skin-related induced by exposure to diesel or gas engine exhaust, tobacco smoke, insecticide, gasoline, paint or paint thinner, cleaning products, fragrances, tar or asphalt, nail polish or hairspray, and new furnishings...
2017: Journal of Medical Investigation: JMI
https://www.readbyqxmd.com/read/28954373/coal-water-slurries-containing-petrochemicals-to-solve-problems-of-air-pollution-by-coal-thermal-power-stations-and-boiler-plants-an-introductory-review
#20
Margarita A Dmitrienko, Pavel A Strizhak
This introductory study presents the analysis of the environmental, economic and energy performance indicators of burning high-potential coal water slurries containing petrochemicals (CWSP) instead of coal, fuel oil, and natural gas at typical thermal power stations (TPS) and a boiler plant. We focus on the most hazardous anthropogenic emissions of coal power industry: sulfur and nitrogen oxides. The research findings show that these emissions may be several times lower if coal and oil processing wastes are mixed with water as compared to the combustion of traditional pulverized coal, even of high grades...
September 23, 2017: Science of the Total Environment
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