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https://www.readbyqxmd.com/read/28434248/are-university-students-in-singapore-meeting-the-international-and-national-recommended-daily-servings-of-fruits-and-vegetables
#1
Raymond Boon Tar Lim, Dede Kam Tyng Tham, Falk Müller-Riemenschneider, Mee Lian Wong
Data are lacking on fruit and vegetable (FV) consumption among young adults in the Asia-Pacific region. The aim of this study is to assess the prevalence of students who met the international and national recommendation of daily consumption of 5 and 4 FV servings, respectively, in a university in Singapore and the factors associated with meeting the national recommendation. A cross-sectional survey using proportional stratified random sampling was conducted on 884 undergraduates in 2013. The prevalence of meeting the international and national recommendation was 13...
April 2017: Asia-Pacific Journal of Public Health
https://www.readbyqxmd.com/read/28428827/fundamental-research-on-the-action-mechanism-of-the-800-nm-semiconductor-laser-on-skin-blackheads-and-coarse-pores
#2
Jie Lin, Li Jing, Hao Zhu, Fu-Sheng Dong
The aim of the study was to determine the mechanism of action of the 800 nm semiconductor laser on skin blackheads and coarse pores. A total of 24 healthy purebred short-haired male guinea pigs, weighing 350-400 g, were selected and smeared with 0.5 ml coal tar suspension evenly by injector once daily. Treatment was continued for 14 days to form an experimental area of 8×3 cm on the back of the guinea pigs. The animals were divided into the following groups: Normal control group (NC), low-dose laser treatment group (L-LS), high-dose laser treatment group (H-LS), and Q-switched Nd:YAG treatment group (QC)...
January 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28428525/-total-arch-replacement-using-manufactured-frozen-elephant-trunk-after-acute-type-a-dissection-repair
#3
Makoto Hibino, Masato Mutsuga, Hideki Oshima, Yuji Narita, Tomonobu Abe, Kazuro Fujimoto, Yoshiyuki Tokuda, Akihiko Usui
The purpose of this study is to assess the result of total arch replacement(TAR) using manufactured frozen elephant trunk(FET) for chronic aortic dissection after initial repair including the effect of aortic remodeling by the FET. Between 2003 and 2015, we performed 11 TAR using manufactured FET. Initial repairs before were 9 ascending aortic replacements and 2 Bentall operations. The entry of residual dissection was located at arch in 7 and at distal anastomosis site in 4. There was no hospital death. The operative complication included 2 surgical site infection, 1 interstitial pneumonia and 1 paraplegia with almost full recovery...
April 2017: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/28425054/can-a-three-component-prosthesis-be-used-for-conversion-of-painful-ankle-arthrodesis-to-total-ankle-replacement
#4
Markus Preis, Travis Bailey, Lucas S Marchand, Alexej Barg
BACKGROUND: In patients with painful ankle arthrodesis, the surgical treatment is challenging, and may include takedown of ankle arthrodesis and conversion to a total ankle replacement (TAR). This procedure is technically demanding given the altered anatomy after arthrodesis. Few studies have evaluated TAR in the setting of prior arthrodesis. QUESTIONS/PURPOSES: (1) What intraoperative and perioperative complications were observed in patients who underwent conversion of an ankle arthrodesis to a TAR? (2) Was durable fixation achieved at short term, and what was the alignment of the components? (3) What subsequent surgical procedures were performed, including revisions? (4) What improvements were observed in pain, tibiotalar range of motion (ROM), and quality of life? METHODS: Between January 2007 and December 2014, 18 patients with a painful ankle arthrodesis underwent conversion to TAR at our tertiary referral center...
April 19, 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/28421535/microrna-metabolism-and-dysregulation-in-amyotrophic-lateral-sclerosis
#5
REVIEW
Paola Rinchetti, Mafalda Rizzuti, Irene Faravelli, Stefania Corti
MicroRNAs (miRNAs) are a subset of endogenous, small, non-coding RNA molecules involved in the post-transcriptional regulation of eukaryotic gene expression. Dysregulation in miRNA-related pathways in the central nervous system (CNS) is associated with severe neuronal injury and cell death, which can lead to the development of neurodegenerative disorders, such as amyotrophic lateral sclerosis (ALS). ALS is a fatal adult onset disease characterized by the selective loss of upper and lower motor neurons. While the pathogenesis of ALS is still largely unknown, familial ALS forms linked to TAR DNA-binding protein 43 (TDP-43) and fused in sarcoma (FUS) gene mutations, as well as sporadic forms, display changes in several steps of RNA metabolism, including miRNA processing...
April 18, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28419290/svmqa-support-vector-machine-based-protein-single-model-quality-assessment
#6
Balachandran Manavalan, Jooyoung Lee
Motivation: The accurate ranking of predicted structural models and selecting the best model from a given candidate pool remain as open problems in the field of structural bioinformatics. The quality assessment (QA) methods used to address these problems can be grouped into two categories: consensus methods and single-model methods. Consensus methods in general perform better and attain higher correlation between predicted and true quality measures. However, these methods frequently fail to generate proper quality scores for native-like structures which are distinct from the rest of the pool...
April 13, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28418268/the-folding-competence-of-hiv-1-tat-mediated-by-interaction-with-tar-rna
#7
Jung Min Kim, Hee Sun Choi, Baik Lin Seong
The trans-activator Tat protein of HIV-1 belongs to the large family of intrinsically disordered proteins (IDPs), and is known to recruit various host proteins for the transactivation of viral RNA synthesis. Tat protein interacts with the transactivator response RNA (TAR RNA), exhibiting RNA chaperone activities for structural rearrangement of interacting RNAs. Here, considering that Tat-TAR RNA interaction is mutually cooperative, we examined the potential role of TAR RNA as Chaperna - RNA that provides chaperone function to proteins - for the folding of HIV-1 Tat...
April 18, 2017: RNA Biology
https://www.readbyqxmd.com/read/28416101/n-substituted-and-ring-opened-saccharin-derivatives-selectively-inhibit-transmembrane-tumor-associated-carbonic-anhydrases-ix-and-xii
#8
Jekaterīna Ivanova, Fabrizio Carta, Daniela Vullo, Janis Leitans, Andris Kazaks, Kaspars Tars, Raivis Žalubovskis, Claudiu T Supuran
A series of N-substituted saccharins incorporating aryl, alkyl and alkynyl moieties, as well as some ring opened derivatives were prepared and investigated as inhibitors of the metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1). The widespread cytosolic isoforms CA I and II were not inhibited by these sulfonamides whereas transmembrane, tumor-associated ones were effectively inhibited, with KIs in the range of 22.1-481nM for CA IX and of 3.9-245nM for hCA XII. Although the inhibition mechanism of these tertiary/secondary sulfonamides is unknown for the moment, the good efficacy and especially selectivity for the inhibition of the tumor-associated over the cytosolic, widespread isoforms, make these derivatives of considerable interest as enzyme inhibitors with various pharmacologic applications...
April 7, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28414228/molecular-aspects-of-a-robust-assay-for-ferroxidase-function-of-ceruloplasmin
#9
Laura Cortes, Blaine R Roberts, Anthony G Wedd, Zhiguang Xiao
Ceruloplasmin (Cp) is one of the most complex multicopper oxidase enzymes and plays an essential role in the metabolism of iron in mammals. Ferrous ion supplied by the ferroportin exporter is converted by Cp to ferric ion that is accepted by plasma metallo-chaperone transferrin. Study of the enzyme at the atomic and molecular level has been hampered by the lack of a suitable ferrous substrate. We have developed the classic chromophoric complex Fe(II)Hx(Tar)2 (H2Tar, 4-(2-thiazolylazo)resorcinol; x = 0-2; overall charge omitted) as a robust substrate for evaluation of the ferroxidase function of Cp and related enzymes...
April 17, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28395086/regional-overlap-of-pathologies-in-lewy-body-disorders
#10
Martí Colom-Cadena, Oriol Grau-Rivera, Lluís Planellas, Catalina Cerquera, Estrella Morenas, Sergio Helgueta, Laia Muñoz, Jaime Kulisevsky, Maria Jose Martí, Eduard Tolosa, Jordi Clarimon, Alberto Lleó, Ellen Gelpi
Lewy body disorders (LBD) are common neurodegenerative diseases characterized by the presence of aggregated α-synuclein in Lewy bodies and Lewy neurites in the central and peripheral nervous systems. The brains of patients with LBD often display other comorbid pathologies, i.e. insoluble tau, β-amyloid aggregates, TAR DNA-binding protein 43 (TDP-43) deposits, and argyrophilic grain disease (AGD). The incidence and physiological relevance of these concurrent pathological findings remain controversial. We performed a semiquantitative detailed mapping of α-synuclein, tau, β-amyloid (Aβ), TDP-43, and AGD pathologies in 17 areas in 63 LBD cases (44 with Parkinson disease [PD], 28 with dementia, and 19 with dementia with Lewy bodies)...
March 1, 2017: Journal of Neuropathology and Experimental Neurology
https://www.readbyqxmd.com/read/28393838/functional-polymorphisms-in-dopaminergic-genes-modulate-neurobehavioral-and-neurophysiological-consequences-of-sleep-deprivation
#11
Sebastian C Holst, Thomas Müller, Amandine Valomon, Britta Seebauer, Wolfgang Berger, Hans-Peter Landolt
Sleep deprivation impairs cognitive performance and reliably alters brain activation in wakefulness and sleep. Nevertheless, the molecular regulators of prolonged wakefulness remain poorly understood. Evidence from genetic, behavioral, pharmacologic and imaging studies suggest that dopaminergic signaling contributes to the behavioral and electroencephalographic (EEG) consequences of sleep loss, although direct human evidence thereof is missing. We tested whether dopamine neurotransmission regulate sustained attention and evolution of EEG power during prolonged wakefulness...
April 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28390775/deep-transcranial-magnetic-stimulation-of-the-dorsolateral-prefrontal-cortex-in-alcohol-use-disorder-patients-effects-on-dopamine-transporter-availability-and-alcohol-intake
#12
Giovanni Addolorato, Mariangela Antonelli, Fabrizio Cocciolillo, Gabriele A Vassallo, Claudia Tarli, Luisa Sestito, Antonio Mirijello, Anna Ferrulli, Daniele A Pizzuto, Giovanni Camardese, Antonio Miceli, Marco Diana, Alessandro Giordano, Antonio Gasbarrini, Daniela Di Giuda
Repetitive Transcranial Magnetic Stimulation (rTMS) of the dorsolateral prefrontal cortex may affect neuro-adaptations associated with alcohol use disorder (AUD), potentially influencing craving and alcohol intake. We investigated alcohol intake and dopamine transporter (DAT) availability by Single Photon Emission Computed Tomography (SPECT) in the striatum of AUD patients before and after deep rTMS. Fourteen patients underwent baseline clinical and SPECT assessment. Eleven out of fourteen patients were randomized into two groups for the REAL (n...
April 5, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28385511/aliphatic-and-polycyclic-aromatic-hydrocarbons-in-surface-sediments-collected-from-mangroves-with-different-levels-of-urbanization-in-southern-brazil
#13
Maíra Algarve Assunção, Morgana Frena, Ana Paula Stein Santos, Luiz Augusto Dos Santos Madureira
Three mangroves located in southern Brazil, Carijós (CA), Rio Tavares (RT) and Itacorubi (ITA), with distinct anthropogenic influences, were assessed with regard to the presence of aliphatic and polycyclic aromatic hydrocarbons (PAH). In this study, the n-alkane concentrations ranged from 1.9μg g(-1) (CA) to 55.6μg g(-1) (ITA) (dry weight). The carbon preference index (CPI) ranged from 2.1 to 7.9 and values for the terrestrial/aquatic ratio (TAR) were >1. Thus, both indexes indicated the predominance of sediment of terrestrial origin, mainly comprised of higher plants...
April 3, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28380366/preliminary-test-of-cigarette-nicotine-discrimination-threshold-in-non-dependent-versus-dependent-smokers
#14
Kenneth A Perkins, Nicole Kunkle, Joshua L Karelitz, K A Perkins, N Kunkle, J L Karelitz
BACKGROUND: Despite its potential for understanding tobacco dependence, behavioral discrimination of nicotine via smoking has not been formally examined as a function of nicotine dependence level. METHODS: Spectrum research cigarettes were used to compare non-dependent with dependent smokers on the lowest content of nicotine they could discriminate (i.e., "threshold"). Dependent (n=21; 16M, 5F) or non-dependent (n=7; 4M, 3F) smokers were tested on ability to discriminate between cigarettes with nicotine contents of 17, 11, 5, 2, and 1mg/g, one per session, from an "ultra-low" cigarette with 0...
March 23, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28380257/tdp-43-and-fus-en-route-from-the-nucleus-to-the-cytoplasm
#15
REVIEW
Helena Ederle, Dorothee Dormann
Misfolded or mislocalized RNA-binding proteins (RBPs) and, consequently, altered mRNA processing, can cause neuronal dysfunction, eventually leading to neurodegeneration. Two prominent examples are the RBPs TAR DNA-binding protein of 43 kDa (TDP-43) and fused in sarcoma (FUS), which form pathological messenger ribonucleoprotein aggregates in patients suffering from amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), two devastating neurodegenerative disorders. Here, we review the multiple functions of TDP-43 and FUS in mRNA processing, both in the nucleus and in the cytoplasm...
April 5, 2017: FEBS Letters
https://www.readbyqxmd.com/read/28373710/single-cell-imaging-and-quantification-of-tdp-43-and-%C3%AE-synuclein-intercellular-propagation
#16
Sivan Peled, Dorin Sade, Yaron Bram, Ziv Porat, Topaz Kreiser, Michael Mimouni, Alexandra Lichtenstein, Daniel Segal, Ehud Gazit
The intercellular spreading of protein assemblies is a major factor in the progression of neurodegenerative disorders. The quantitative study and visualization of cell-to-cell propagation using tagged-proteins is challenging due to the steric effect of relatively large fluorescence tags and the risk of 'false positive' identification when analyzing these rare transmission events. Here, we established a cell culture model to characterize the cell-to-cell transmission of TAR DNA-binding protein and α-synuclein, involved in amyotrophic lateral sclerosis and Parkinson's disease, respectively, using the small nine amino acid influenza hemagglutinin tag...
March 28, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28372926/epsilonproteobacteria-dominate-bacterial-diversity-at-a-natural-tar-seep
#17
Florence Lormières, Phil M Oger
The bacterial diversity of a naturally seeping bitumen source was investigated by 16S rRNA gene cloning and sequencing. Epsilonproteobacteria were shown to dominate the bacterial diversity in the underground water and within the bitumen, representing ca. 75% of the total bacterial diversity. These Epsilonproteobacteria were dominated by Sulfurimonas OTUs, while Sulfurovum and Arcobacter OTUs completed the remaining diversity. Epsilonproteobacteria are sulfur-oxidizer, nitrate-reducing chemo-lithoautotrophic bacteria, unable to use most organics for growth but capable of CO2 fixation...
March 31, 2017: Comptes Rendus Biologies
https://www.readbyqxmd.com/read/28372360/a-modular-high-throughput-in-vivo-screening-platform-based-on-chimeric-bacterial-receptors
#18
Christina E Lehning, Jan B Heidelberger, John Reinhard, Morten H H Nørholm, Roger R Draheim
Multidrug resistance (MDR) is a globally relevant problem that requires novel approaches. Two-component systems are a promising, yet untapped target for novel antibacterials. They are prevalent in bacteria and absent in mammals, and their activity can be modulated upon perception of various stimuli. Screening pre-existing compound libraries could reveal small molecules that inhibit stimulus-perception by virulence-modulating receptors, reduce signal output from essential receptors or identify artificial stimulatory ligands for novel SHKs that are involved in virulence...
April 7, 2017: ACS Synthetic Biology
https://www.readbyqxmd.com/read/28370534/topical-treatment-of-psoriasis-questionnaire-results-on-topical-therapy-accessibility-and-influence-of-body-surface-area-on-usage
#19
L Iversen, M M Lange, R Bissonette, A V E Carvalho, P C van de Kerkhof, B Kirby, C E Kleyn, C W Lynde, J M van der Walt, J J Wu
BACKGROUND: Topical treatment of mild to moderate psoriasis is first line treatment and exhibits varying degrees of success across patient groups. Key factors influencing treatment success are physician topical treatment choice (high efficacy, low adverse events) and strict patient adherence. Currently, no formalized, international consensus guidelines exist to direct optimal topical treatment, although many countries have national guidelines. OBJECTIVE: To describe and analyze cross-regional variations in the use and access of psoriasis topical therapies...
April 1, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28367692/operative-wound-complications-following-total-ankle-arthroplasty
#20
Christopher E Gross, Kamran S Hamid, Cynthia Green, Mark E Easley, James K DeOrio, James A Nunley
BACKGROUND: Wound complications following total ankle replacement (TAR) potentially lead to devastating consequences. The aim of this study was to compare the operative and demographic differences in patients with and without major wound problems which required operative management. We hypothesized that increased tourniquet and operative time would negatively influence wound healing. METHODS: We identified a consecutive series of 762 primary TARs performed between December 1999 and April 2014 whose data were prospectively collected...
April 2017: Foot & Ankle International
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