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https://www.readbyqxmd.com/read/26123368/location-of-radiosensitive-organs-inside-pediatric-anthropomorphic-phantoms-data-required-for-dosimetry
#1
Stephen Inkoom, Maria Raissaki, Kostas Perisinakis, Thomas G Maris, John Damilakis
PURPOSE: The aim of this study was to determine the location of radiosensitive organs in the interior of four pediatric anthropomorphic phantoms for dosimetric purposes. METHODS: Four pediatric anthropomorphic phantoms representing the average individual as newborn, 1-year-old, 5-year-old and 10-year-old child underwent head, thorax and abdomen CT scans. CT and MRI scans of all children aged 0-16 years performed during a 5-year-period in our hospital were reviewed, and 503 were found to be eligible for normal anatomy...
December 2015: Physica Medica: PM
https://www.readbyqxmd.com/read/24938427/integrative-genomic-analyses-of-secreted-protein-acidic-and-rich-in-cysteine-and-its-role-in-cancer-prediction
#2
Bo Wang, Kai Chen, Wenming Xu, Di Chen, Wei Tang, Tian-Song Xia
Secreted protein acidic and rich in cysteine (SPARC), also termed osteonectin or basement‑membrane‑40 (BM‑40), is a matrix‑associated protein that elicits changes in cell shape, inhibits cell‑cycle progression and affects the synthesis of extracellular matrix (ECM). The final mature SPARC protein has 286 amino acids with three distinct domains, including an NH2‑terminal acidic domain (NT), follistatin‑like domain (FS) and C terminus domain (EC). The present study identified SPARC genes from 14 vertebrate genomes and revealed that SPARC existed in all types of vertebrates, including fish, amphibians, birds and mammals...
September 2014: Molecular Medicine Reports
https://www.readbyqxmd.com/read/24535227/integrative-genomic-analyses-of-the-histamine-h1-receptor-and-its-role-in-cancer-prediction
#3
Minghai Wang, Xiaolong Wei, Lianghui Shi, Bin Chen, Guohai Zhao, Haiwei Yang
The human histamine receptor H1 (HRH1) gene is located on chromosome 3p25 and encodes for a 487 amino acid G protein-coupled receptor (GPCR) with a long third intracellular loop (IL3). The HRH1 predominantly couples to Gαq/11 proteins, leading to the activation of phospholipase C (PLC) and subsequent release of the second messengers inositol trisphosphate (IP3) and diacylglycerol (DAG) followed by the activation of PKC and the release of [Ca2+]i. In the present study, we identified HRH1 genes from 14 vertebrate genomes and found that HRH1 exists in all types of vertebrates including fish, amphibians, birds and mammals...
April 2014: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/23087907/foxm1-coming-of-age-time-for-translation-into-clinical-benefits
#4
Muy-Teck Teh
A decade since the first evidence implicating the cell cycle transcription factor Forkhead Box M1 (FOXM1) in human tumorigenesis, a slew of subsequent studies revealed an oncogenic role of FOXM1 in the majority of human cancers including oral, nasopharynx, oropharynx, esophagus, breast, ovary, prostate, lung, liver, pancreas, kidney, colon, brain, cervix, thyroid, bladder, uterus, testis, stomach, skin, and blood. Its aberrant upregulation in almost all different cancer types suggests a fundamental role for FOXM1 in tumorigenesis...
2012: Frontiers in Oncology
https://www.readbyqxmd.com/read/23085014/vitamin-d-health-panacea-or-false-prophet
#5
REVIEW
Michael J Glade
Vitamin D deficiency, diagnosed when the serum 25-hydroxyvitamin D (25-OHD(3)) concentration is less than 20 ng/mL, has joined vitamin A deficiency as two of the most common nutrition-responsive medical conditions worldwide. There have been more scientific articles published about vitamin D in the 21st century than about any other vitamin, reflecting the massive expansion of the field of vitamin D research. Adequate vitamin D status has been linked to decreased risks of developing specific cancers, including cancers of the esophagus, stomach, colon, rectum, gallbladder, pancreas, lung, breast, uterus, ovary, prostate, urinary bladder, kidney, skin, thyroid, and hematopoietic system (e...
January 2013: Nutrition
https://www.readbyqxmd.com/read/22288963/napsin-a-a-new-marker-for-lung-adenocarcinoma-is-complementary-and-more-sensitive-and-specific-than-thyroid-transcription-factor-1-in-the-differential-diagnosis-of-primary-pulmonary-carcinoma-evaluation-of-1674-cases-by-tissue-microarray
#6
Bradley M Turner, Philip T Cagle, Irma M Sainz, Junya Fukuoka, Steven S Shen, Jaishree Jagirdar
CONTEXT: Differentiation of non-small cell carcinoma into histologic types is important because of new, successful therapies that target lung adenocarcinoma (ACA). TTF-1 is a favored marker for lung ACA but has limited sensitivity and specificity. Napsin A (Nap-A) is a functional aspartic proteinase that may be an alternative marker for primary lung ACA. OBJECTIVES: To compare Nap-A versus TTF-1 in the typing of primary lung carcinoma and the differentiation of primary lung ACA from carcinomas of other sites...
February 2012: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/20063549/cancer-incidence-among-the-bahraini-population-a-five-year-1998-2002-experience
#7
Jamal Alsayyad, Randah Hamadehb
BACKGROUND: Cancer is the second leading cause of death, following cardiovascular diseases, accounting for 12% of annually reported deaths in Bahrain. We determined the epidemiological patterns of malignancies in Bahrain and compared them with those of other Gulf Cooperation Council (GCC) countries and other developed countries. SUBJECTS AND METHODS: Data for the study were obtained from the Bahrain Cancer Registry (BCR) database. The overall and type-specific 5-year average incidence rates were calculated for the years 1998-2002 and derived using the CANREG software formula...
July 2008: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/19252338/tissue-specific-mrna-expression-profiles-of-human-solute-carrier-35-transporters
#8
Masuhiro Nishimura, Satoshi Suzuki, Tetsuo Satoh, Shinsaku Naito
Pairs of forward and reverse primers and TaqMan probes specific to each of 23 human solute carrier 35 (SLC35) transporters were prepared. The mRNA expression level of each target transporter was analyzed in total RNA from single and pooled specimens of adult human tissues (adipose tissue, adrenal gland, bladder, bone marrow, brain, cerebellum, colon, heart, kidney, liver, lung, mammary gland, ovary, pancreas, peripheral leukocytes, placenta, prostate, retina, salivary gland, skeletal muscle, small intestine, smooth muscle, spinal cord, spleen, stomach, testis, thymus, thyroid gland, tonsil, trachea, and uterus), from pooled specimens of fetal human tissues (brain, heart, kidney, liver, spleen, and thymus), and from three human cell lines (HeLa cell line ATCC#: CCL-2, human cell line Hep G2, and human breast carcinoma cell line MDA-435) by real-time reverse transcription PCR using an Applied Biosystems 7500 Fast Real-Time PCR System...
2009: Drug Metabolism and Pharmacokinetics
https://www.readbyqxmd.com/read/18928529/expression-of-interleukin-17rc-protein-in-normal-human-tissues
#9
Dongxia Ge, Zongbing You
BACKGROUND: Interleukin-17 (IL-17) cytokines and receptors play an important role in many autoimmune and inflammatory diseases. IL-17 receptors IL-17RA and IL-17RC have been found to form a heterodimer for mediating the signals of IL-17A and IL-17F cytokines. While the function and signaling pathway of IL-17RA has been revealed, IL-17RC has not been well characterized. The function and signaling pathway of IL-17RC remain largely unknown. The purpose of the present study was to systematically examine IL-17RC protein expression in 53 human tissues...
2008: International Archives of Medicine
https://www.readbyqxmd.com/read/18318581/application-of-immunohistochemistry-to-the-diagnosis-of-primary-and-metastatic-carcinoma-to-the-lung
#10
REVIEW
Jaishree Jagirdar
CONTEXT: Immunohistochemistry is a very valuable and often used tool in the differential diagnosis of lung carcinomas whether primary or secondary to the lung. The most useful application is in distinguishing primary lung tumors from metastatic tumors to the lung from common sites (colon, breast, prostate, pancreas, stomach, kidney, bladder, ovaries, and uterus). Immunohistochemistry also aids in the separation of small cell carcinoma from non-small cell carcinoma and carcinoids particularly in small biopsy specimens limited by artifact...
March 2008: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/18282806/association-of-insurance-status-and-ethnicity-with-cancer-stage-at-diagnosis-for-12-cancer-sites-a-retrospective-analysis
#11
Michael T Halpern, Elizabeth M Ward, Alexandre L Pavluck, Nicole M Schrag, John Bian, Amy Y Chen
BACKGROUND: Individuals in the USA without private medical insurance are less likely to have access to medical care or participate in cancer screening programmes than those with private medical insurance. Smaller regional studies in the USA suggest that uninsured and Medicaid-insured individuals are more likely to present with advanced-stage cancer than privately insured patients; however, this finding has not been assessed using contemporary, national-level data. Furthermore, patients with cancer from ethnic minorities are more likely to be uninsured or Medicaid-insured than non-Hispanic white people...
March 2008: Lancet Oncology
https://www.readbyqxmd.com/read/18177573/-normal-variants-and-frequent-pitfalls-with-18-fdg-pet-ct-study
#12
Gisela Del Rocío Estrada-Sánchez, Javier Altamirano-Ley, Francisco Javier Ochoa-Carrillo
BACKGROUND: Fluordeoxyglucose ((18)FDG) is the most common radiotracer used for PET/CT studies. It enters the cell because of the glucose transporter proteins (GLUTs): 1) erythrocytic membrane, skeletal muscle, lymphocytes, ovaries, breast; 2) pancreas, retina, erythrocytes; 3) adipocytes, ovaries, testis; 4) skeletal muscle, adipocytes, ovaries, myocardium; 5) breast, small intestine, testis, kidney, erythrocytes; 6) spleen, leucocytes, brain; 7) liver; 8) testis, brain; 9) liver, kidney; 10) liver, pancreas; 11) heart, muscle; 12) heart, prostate; 13) brain...
November 2007: Cirugia y Cirujanos
https://www.readbyqxmd.com/read/17722996/solid-cancer-incidence-in-atomic-bomb-survivors-1958-1998
#13
D L Preston, E Ron, S Tokuoka, S Funamoto, N Nishi, M Soda, K Mabuchi, K Kodama
This is the second general report on radiation effects on the incidence of solid cancers (cancers other than malignancies of the blood or blood-forming organs) among members of the Life Span Study (LSS) cohort of Hiroshima and Nagasaki atomic bomb survivors. The analyses were based on 17,448 first primary cancers (including non-melanoma skin cancer) diagnosed from 1958 through 1998 among 105,427 cohort members with individual dose estimates who were alive and not known to have had cancer prior to 1958. Radiation-associated relative risks and excess rates were considered for all solid cancers as a group, for 19 specific cancer sites or groups of sites, and for five histology groups...
July 2007: Radiation Research
https://www.readbyqxmd.com/read/17684428/cancer-incidence-among-the-bahraini-population-a-five-year-1998-2002-experience
#14
Jamal Alsayyad, Radah Hamadeh
BACKGROUND: Cancer is the second leading cause of death, following cardiovascular diseases, accounting for 12% of annually reported deaths in Bahrain. We determined the epidemiological patterns of malignancies in Bahrain and compared them with those of other Gulf Cooperation Council (GCC) countries and other developed countries. SUBJECTS AND METHODS: Data for the study were obtained from the Bahrain Cancer Registry (BCR) database. The overall and type-specific 5-year average incidence rates were calculated for the years 1998-2002 and derived using the CANREG software formula...
July 2007: Annals of Saudi Medicine
https://www.readbyqxmd.com/read/17593839/-the-predictive-value-of-the-tokuhashi-revised-scoring-system-for-the-survival-time-of-patients-with-spinal-metastases
#15
Jian-cheng Zeng, Yue-ming Song, Hao Liu, Quan Gong, Tao Li, Li-ming Liu, Yun-zhou Hu, Fu-xing Pei, Shu-cheng Rao
OBJECTIVE: To evaluate the predictive value of the Tokuhashi revised scoring system for the life expectancy of patients with spinal metastases. METHODS: A retrospective review of 447 patients with spinal metastases was performed, which comprised 291 men and 156 women with a mean age of 56. 1 years. All of the patients were scored with the Tokuhashi revised scoring system based on the available clinical, pathological and radiographic data. The relation between the survival time and the Tokuhashi revised score was analyzed...
June 2007: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/17096841/solar-ultraviolet-b-exposure-and-cancer-incidence-and-mortality-in-the-united-states-1993-2002
#16
Francis P Boscoe, Maria J Schymura
BACKGROUND: An inverse relationship between solar ultraviolet-B (UV-B) exposure and non-skin cancer mortality has long been reported. Vitamin D, acquired primarily through exposure to the sun via the skin, is believed to inhibit tumor development and growth and reduce mortality for certain cancers. METHODS: We extend the analysis of this relationship to include cancer incidence as well as mortality, using higher quality and higher resolution data sets than have typically been available...
2006: BMC Cancer
https://www.readbyqxmd.com/read/15195115/expression-of-a-colorectal-antigen-defined-by-a-new-monoclonal-antibody-co-tl1
#17
Gerdy B ten Dam, Lambert G Poels, Rogier Pullens, Paul H K Jap, Fred J J M van de Molengraft
A murine monoclonal antibody (MoAb CO-TL1, IgG1) has been raised by differential screening of hybridoma supernatants on sections of human large and small intestines, followed by screening on colon adenomas as well as on colorectal carcinomas. In both paraffin sections and cryostat sections, the antibody stained strongly all cell types in adult, neonatal and fetal human colorectal epithelium, that is, the goblet cells, the columnar cells and the endocrine cells. No staining was observed in the remaining parts of the normal gastrointestinal tract and other tissues...
September 2004: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/11012454/solitary-pulmonary-nodules-in-patients-with-extrapulmonary-neoplasms
#18
L E Quint, C H Park, M D Iannettoni
PURPOSE: To determine the frequency of single lung metastasis, primary lung cancer, and benign lesions in patients with a solitary lung nodule and a primary extrapulmonary neoplasm. MATERIALS AND METHODS: The authors evaluated the electronic charts of 149 patients with an extrapulmonary malignant neoplasm and a solitary pulmonary nodule. The histologic characteristics of the nodule were correlated with those of the extrapulmonary neoplasm and with patient age and smoking history...
October 2000: Radiology
https://www.readbyqxmd.com/read/8809738/a-and-b-forms-of-the-androgen-receptor-are-expressed-in-a-variety-of-human-tissues
#19
C M Wilson, M J McPhaul
Human genital skin fibroblasts contain both the full-length 110 K androgen receptor protein (AR-B, apparent M(r) approximately 110,000) and an 87 K N-terminally truncated AR isoform (AR-A, apparent M(r) approximately 87,000). These two AR species are structurally analogous to the A- and B-isoforms of the progesterone receptor (PR). We examined the distribution pattern of human AR isoforms in a variety of fetal and adult tissues by Western blot analysis. Relative levels of immunoreactive AR proteins in high salt tissue extracts were estimated by densitometry in comparison to a standard normal genital skin fibroblast preparation...
June 18, 1996: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/8127954/cancer-incidence-in-atomic-bomb-survivors-part-iv-comparison-of-cancer-incidence-and-mortality
#20
COMPARATIVE STUDY
E Ron, D L Preston, K Mabuchi, D E Thompson, M Soda
This report compares cancer incidence and mortality among atomic bomb survivors in the Radiation Effects Research Foundation Life Span Study (LSS) cohort. Because the incidence data are derived from the Hiroshima and Nagasaki tumor registries, case ascertainment is limited to the time (1958-1987) and geographic restrictions (Hiroshima and Nagasaki) of the registries, whereas mortality data are available from 1950-1987 anywhere in Japan. With these conditions, there were 9,014 first primary incident cancer cases identified among LSS cohort members compared with 7,308 deaths for which cancer was listed as the underlying cause of death on death certificates...
February 1994: Radiation Research
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