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https://www.readbyqxmd.com/read/28437804/-prognostic-factors-of-open-abdomen-treatment-in-visceral-surgery
#1
Martin W von Websky, Agnes Jedig, Arnulf Willms, Azin Jafari, Hanno Matthaei, Jörg C Kalff, Steffen Manekeller
Introduction In general surgery, open abdomen treatment (OAT) is used to treat abdominal compartment syndrome (ACS) and sepsis, often after a primary surgical procedure associated with complications. The results achieved in this patient population may depend on factors that are yet unknown. This study evaluates independent patient-related prognostic factors after OAT. Methods 38 clinical parameters and survival data of 165 consecutive general surgery patients after OAT were entered into a prospective database according to a defined algorithm in order to analyse the underlying surgical pathology, predictors of survival and important aspects of OAT-related morbidity...
April 24, 2017: Zentralblatt Für Chirurgie
https://www.readbyqxmd.com/read/28437596/membrane-transport-status-does-not-predict-peritonitis-risk-in-patients-on-peritoneal-dialysis
#2
Sarah So, Laraine Aw, Kamal Sud, Vincent W Lee
AIM: To determine whether peritoneal membrane transport status (MTS) is associated with peritonitis or poor peritoneal dialysis (PD)-related outcomes. METHODS: This retrospective cohort study analysed data of incident adult patients on PD in Western Sydney between October 1, 2003 and December 31, 2012. Only patients who underwent peritoneal equilibration and adequacy tests within 6 months of commencement were included. Kaplan-Meier survival curves for time until first peritonitis and time until composite endpoint of peritonitis, death, or technique failure, censored for transplant, were constructed...
April 24, 2017: Nephrology
https://www.readbyqxmd.com/read/28436955/vitamin-a-mediates-conversion-of-monocyte-derived-macrophages-into-tissue-resident-macrophages-during-alternative-activation
#3
Uma Mahesh Gundra, Natasha M Girgis, Michael A Gonzalez, Mei San Tang, Hendrik J P Van Der Zande, Jian-Da Lin, Mireille Ouimet, Lily J Ma, Jordan Poles, Nikollaq Vozhilla, Edward A Fisher, Kathryn J Moore, P'ng Loke
It remains unclear whether activated inflammatory macrophages can adopt features of tissue-resident macrophages, or what mechanisms might mediate such a phenotypic conversion. Here we show that vitamin A is required for the phenotypic conversion of interleukin 4 (IL-4)-activated monocyte-derived F4/80(int)CD206(+)PD-L2(+)MHCII(+) macrophages into macrophages with a tissue-resident F4/80(hi)CD206(-)PD-L2(-)MHCII(-)UCP1(+) phenotype in the peritoneal cavity of mice and during the formation of liver granulomas in mice infected with Schistosoma mansoni...
April 24, 2017: Nature Immunology
https://www.readbyqxmd.com/read/28435764/a-case-of-well-differentiated-papillary-mesothelioma-of-the-male-peritoneum-successful-treatment-by-systemic-chemotherapy
#4
Aziz Bazine, Mohamed Fetohi, Tariq Namad, Asmae Benzekri, Brahim Zainoun, Rachid Tanz, Mohamed Ichou
Well-differentiated papillary mesothelioma of the peritoneum (WDPMP) is a rare subtype of epithelioid mesothelioma, which is usually seen in young women without a history of asbestos exposure, and generally, has an indolent course. The relative rarity of this neoplasm in males prompted us to report this case of a well-differentiated papillary mesothelioma of the peritoneum in a 36-year-old man. The patient, who had no history of asbestos exposure, presented with abdominal pain and ascites of unknown etiology...
March 19, 2017: Curēus
https://www.readbyqxmd.com/read/28435129/laparoscopic-sacral-colpopexy-the-%C3%A2-6points-%C3%A2-technique
#5
Marie Schaub Resident, Lise Lecointre, Emilie Faller, Thomas Boisramé, Jean-Jacques Baldauf, Arnaud Wattiez, Cherif Youssef Akladios
STUDY OBJECTIVE: Illustrate laparoscopic sacral colpopexy for pelvic organ prolapse, a new method using a simplified mesh fixation technique, with only six fixation points DESIGN: A step-by-step explanation of the surgery using video (educative video) The video was approved by the local IRB. SETTING: University Hospital of Strasbourg, France. PATIENTS: Women with multicompartment prolapse INTERVENTION: First, we dissect the promontorium, and vertically incise the posterior parietal peritoneum on the right pelvic sidewall until the pouch of Douglas...
April 18, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28434377/a-primary-extraskeletal-osteosarcoma-of-the-mesentery-a-case-report
#6
Nathalie E J van den Broek, Paul Willemsen, Caroline Mattelaer
Extraskeletal osteosarcoma is a rare and invasive malignancy, typically located in the soft tissue without attachment to the skeleton. The present study reports a case of a primary mesenteric extraskeletal osteosarcoma of a 71-year-old woman. The patient complained of an incomplete defecation. Colonoscopy showed an ulcer with impression of external compression of the sigmoid. An additional abdominal computed tomography (CT) scan revealed a large, almost completely calcified, mass in the left lower abdomen causing hydronephrosis of the left kidney...
April 24, 2017: Acta Chirurgica Belgica
https://www.readbyqxmd.com/read/28434080/predictive-risk-factors-for-peritoneal-recurrence-after-pancreatic-cancer-resection-and-strategies-for-its-prevention
#7
Kyohei Ariake, Fuyuhiko Motoi, Hideo Ohtsuka, Koji Fukase, Kunihiro Masuda, Masamichi Mizuma, Hiroki Hayashi, Kei Nakagawa, Takanori Morikawa, Shimpei Maeda, Tatsuyuki Takadate, Takeshi Naitoh, Shinichi Egawa, Michiaki Unno
PURPOSE: To evaluate the risk factors for peritoneal recurrence (PR) of pancreatic adenocarcinoma and to discuss the appropriate management strategies. METHODS: We reviewed the medical records of 236 patients who underwent pancreatectomy for pancreatic adenocarcinoma. We then compared the clinicopathological characteristics of patients with vs. those without PR. The independent risk factors for PR were defined using the Cox proportional hazards regression model...
April 22, 2017: Surgery Today
https://www.readbyqxmd.com/read/28433843/use-of-pneumoperitoneal-puncture-for-peritoneal-catheter-placement-in-lumboperitoneal-shunt-surgery-technical-note
#8
Junhua He, Xin Jin, Jun Kong, Yihai Lin, Zhangyi Wu, Xinwen Zhang
BACKGROUND: In hydrocephalus shunt surgery, a peritoneal catheter is traditionally inserted with laparotomy incision. The abdominal incision length will not be shorter than 3 cm in most cases. A longer incision has to be made in obese patients. The lateral position in lumboperitoneal shunt (LPS) surgery also increases the difficulty of laparotomy. The present report introduces a simple technique of pneumoperitoneal puncture for peritoneal catheter placement in LPS. METHODS: Twenty-eight communicating hydrocephalus cases underwent pneumoperitoneal puncture in an LPS operation...
April 19, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28433563/aryl-thiosemicarbazones-in-vitro-and-immunomodulatory-activities-against-l-amazonensis
#9
Aline Caroline da Silva, Thiago André Ramos Dos Santos, Isis Viviane Bezerra da Silva, Marcos Victor Gregório de Oliveira, Diogo Rodrigo Magalhães Moreira, Ana Cristina Lima Leite, Valéria Rêgo Alves Pereira
Leishmaniasis is an infection caused by different species of Leishmania genus. Currently, there is no vaccine available for Leishmania infections in humans and conventional treatments are limited due to side effects. Therefore, the development of new antileishmanial drugs is an urgent need. In present study, we evaluated the cytotoxicity in host cells, leishmanicidal activity and immunomodulatory potential of seven aryl thiosemicarbazones. Host cell cytotoxicity was determined in peritoneal macrophages of BALB/c mouse, antiparasitic activity was determined against promastigotes and amastigotes of WHOM/00LTB 0016 strain of L...
April 19, 2017: Experimental Parasitology
https://www.readbyqxmd.com/read/28433455/peritoneal-fluid-localization-on-fast-examination-in-the-pediatric-trauma-patient
#10
Timothy E Brenkert, Cynthia Adams, Rebecca L Vieira, Rachel G Rempell
OBJECTIVE: To determine the location of intraperitoneal free fluid on FAST exam in pediatric patients undergoing evaluation for trauma. METHODS: Retrospective review of all FAST exams positive for intraperitoneal free fluid performed in patients sustaining trauma between August 2009 and February 2016 in an urban pediatric emergency department. Positive results were categorized into one of nine potential intraperitoneal locations; 4 each in the right and left upper quadrants, and the pelvis...
April 14, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28433374/peritoneal-fluid-cytokines-related-to-endometriosis-in-patients-evaluated-for-infertility
#11
Hilde Jørgensen, Abby S Hill, Michael T Beste, Manu P Kumar, Evan Chiswick, Peter Fedorcsak, Keith B Isaacson, Douglas A Lauffenburger, Linda G Griffith, Erik Qvigstad
OBJECTIVE: Our aim was to characterize peritoneal cytokine profiles in patients with infertility, with and without endometriosis, to illuminate potential differences in immune profiles that may reflect mechanistic differences between these two patient populations. DESIGN: Cross-sectional study. SETTING: University hospital and research center. PATIENT(S): Women undergoing laparoscopy for infertility investigation (n = 107)...
April 19, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28433249/multicenter-analysis-of-impact-of-anastomotic-leakage-on-long-term-oncologic-outcomes-after-curative-resection-of-colon-cancer
#12
Saori Goto, Suguru Hasegawa, Koya Hida, Ryuji Uozumi, Yukihide Kanemitsu, Toshiaki Watanabe, Kenichi Sugihara, Yoshiharu Sakai
BACKGROUND: In rectal cancer, anastomotic leakage was reported to have a negative impact on both short- and long-term outcomes. However, there is limited data on the impact of anastomotic leakage on oncologic outcomes in patients with colon cancer. We aimed to evaluate the impact of anastomotic leakage on disease recurrence and long-term survival after curative resection of colon cancer. METHODS: This multicenter, retrospective cohort study of 4,919 consecutive patients utilized data from the Japanese Society for Cancer of the Colon and Rectum...
April 19, 2017: Surgery
https://www.readbyqxmd.com/read/28433104/wilson-disease-symptomatic-liver-therapy
#13
Jan Pfeiffenberger, Karl-Heinz Weiss, Wolfgang Stremmel
Wilson disease leads to symptomatic impairment of liver function or liver cirrhosis. Strict adherence to decoppering agents is essential in these patients. Secondary prevention of additional hepatic damage by avoidance of other toxic substances (e.g., alcohol, drugs) and sufficient calorie intake is recommended. Routine examinations in cirrhotic patients include screening for signs of portal hypertension (esophagus varices), development of ascites, and hepatic encephalopathy. Where varices are present, primary or secondary preventive interventions may include treatment with nonselective beta-blockers or variceal ligation, similar to the approach in patients with liver cirrhosis due to other etiologies...
2017: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/28432432/tgf%C3%AE-splicing-and-canonical-pathway-activation-in-high-grade-serous-carcinoma
#14
Neriya Gutgold, Ben Davidson, Liora Jacobs Catane, Arild Holth, Ellen Hellesylt, Claes G Tropé, Anne Dørum, Reuven Reich
The present study analyzed the expression and clinical role of the transforming growth factor-β (TGFβ) pathway in high-grade serous carcinoma (HGSC), with focus on malignant effusions. TGFβ1-3 and TGFβRI-III mRNA expression by qRT-PCR was analyzed in 70 HGSC effusions and 55 solid specimens (28 ovarian, 27 abdominal metastases). Protein expression of Smad2 and Smad3 and their phosphorylated forms by Western blotting was analyzed in 73 specimens (42 effusions, 13 ovarian carcinomas, 18 solid metastases)...
April 21, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28431896/pressurized-intraperitoneal-aerosol-chemotherapy-%C3%A2-practical-aspects
#15
M Hübner, F Grass, H Teixeira-Farinha, B Pache, P Mathevet, N Demartines
INTRODUCTION: Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) has been introduced as novel treatment for peritoneal carcinomatosis. Only proper patient selection, stringent safety protocol and careful surgery allow for a secure procedure. We hereby report the essentials for safe implementation. METHODS: All consecutive procedures within 20 months after PIPAC implementation were analyzed with regards to practical and surgical aspects. Special emphasis was laid on modifications of technique and safety measures during the implementation process with systematic use of a dedicated checklist...
April 8, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28431402/micrometastasis-of-endometriosis-to-distant-organs-in-a-murine-model
#16
Elham N Samani, Ramanaiah Mamillapalli, Fei Li, Levent Mutlu, Demetra Hufnagel, Graciela Krikun, Hugh S Taylor
Endometriosis is an inflammatory gynecological disorder among reproductive-aged women caused by the engraftment and proliferation of endometrial cells outside the uterus, most commonly in the pelvis. It is thought that the disease arises primarily from retrograde menstruation where cells from the endometrium travel through the fallopian tubes to the peritoneal cavity. However, migration of endometriosis-derived cells to distant organs outside of the peritoneal cavity have not been explored. In the present study, we developed and validated a mouse model of disseminated endometriosis using syngeneic DsRed endometrial tissue introduced into the peritoneum of immunocompetent mice...
April 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/28431321/atherogenicity-of-amino-acids-in-the-lipid-laden-macrophage-model-system-in-vitro-and-in-atherosclerotic-mice-a-key-role-for-triglyceride-metabolism
#17
Oren Rom, Claudia Grajeda-Iglesias, Mahmoud Najjar, Niroz Abu-Saleh, Nina Volkova, Dalit Esther Dar, Tony Hayek, Michael Aviram
Atherosclerosis-related research has focused mainly on the effects of lipids on macrophage foam cell formation and atherogenesis, whereas the role of amino acids (AAs) was understudied. The current study aimed to identify anti- or pro-atherogenic AA in the macrophage model system and to elucidate the underlying metabolic and molecular mechanisms. J774A.1 cultured macrophages were treated with increasing concentrations of each 1 of the 20 AAs. Macrophage atherogenicity was assessed in terms of cellular toxicity, generation of reactive oxygen species (ROS) and cellular cholesterol or triglyceride content...
April 6, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28431112/long-term-survival-of-the-mouse-es-cell-derived-mast-cell-medmc-brc6-in-mast-cell-deficient-kitw-sh-w-sh-mice
#18
Shohei Shibagaki, Satoko Tahara-Hanaoka, Takashi Hiroyama, Yukio Nakamura, Akira Shibuya
Mast cells (MCs) play pivotal roles in allergic reactions and the host defense against microbial infection through the immunoglobulin E (IgE)-dependent and IgE-independent signaling pathways. MC lines that can be analyzed both in vitro and in vivo would be useful for the study of MC-dependent immune responses. Here we investigated the functional characteristics of a mouse ES cell-derived mast cell-like cell line, MEDMC-BRC6. The cell line expressed FcεRI and c-Kit and showed degranulation and production of inflammatory cytokines and chemokine, including TNF-α, IL-6 and MCP-1, upon crosslinking FcεRI with IgE...
April 18, 2017: International Immunology
https://www.readbyqxmd.com/read/28431099/effect-of-cold-water-induced-stress-on-immune-response-pathology-and-fertility-in-mice-during-chlamydia-muridarum-genital-infection
#19
Tesfaye Belay, Anthony Woart, Vincent Graffeo
Genital infection by Chlamydia trachomatis (CT) is the most common bacterial sexually-transmitted disease worldwide. It causes serious reproductive health complications, including pelvic inflammatory disease and infertility. Stress is implicated as a risk factor for various infections; however, its effect on chlamydia genital infection is unknown. We previously showed that repeated exposure of mice to cold water results in increased severity of chlamydia genital infection. In the present study, cold water-induced stress resulted in: i) elevated levels of NE and EP in the spleen and genital tract of stressed mice; ii) elevated IL-1β, TNF-α, IL-6 and NO production in macrophage-rich peritoneal cells of mice; iii) supplement of NE in vitro exerts an immunosuppressive effect on splenic T cell production of cytokines; iv) decreased C...
April 18, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/28430830/assessment-of-global-kidney-health-care-status
#20
Aminu K Bello, Adeera Levin, Marcello Tonelli, Ikechi G Okpechi, John Feehally, David Harris, Kailash Jindal, Babatunde L Salako, Ahmed Rateb, Mohamed A Osman, Bilal Qarni, Syed Saad, Meaghan Lunney, Natasha Wiebe, Feng Ye, David W Johnson
Importance: Kidney disease is a substantial worldwide clinical and public health problem, but information about available care is limited. Objective: To collect information on the current state of readiness, capacity, and competence for the delivery of kidney care across countries and regions of the world. Design, Setting, and Participants: Questionnaire survey administered from May to September 2016 by the International Society of Nephrology (ISN) to 130 ISN-affiliated countries with sampling of key stakeholders (national nephrology society leadership, policy makers, and patient organization representatives) identified by the country and regional nephrology leadership through the ISN...
April 21, 2017: JAMA: the Journal of the American Medical Association
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