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https://www.readbyqxmd.com/read/28944992/ginsenoside-rb1-enhances-atherosclerotic-plaque-stability-by-skewing-macrophages-to-the-m2-phenotype
#1
Xue Zhang, Ming-Hao Liu, Lei Qiao, Xin-Yu Zhang, Xiao-Ling Liu, Mei Dong, Hong-Yan Dai, Mei Ni, Xiao-Rong Luan, Jun Guan, Hui-Xia Lu
Atherosclerosis (AS) is characterized as progressive arterial plaque, which is easy to rupture under low stability. Macrophage polarization and inflammation response plays an important role in regulating plaque stability. Ginsenoside Rb1 (Rb1), one of the main active principles of Panax Ginseng, has been found powerful potential in alleviating inflammatory response. However, whether Rb1 could exert protective effects on AS plaque stability remains unclear. This study investigated the role of Rb1 on macrophage polarization and atherosclerotic plaque stability using primary peritoneal macrophages isolated from C57BL/6 mice and AS model in ApoE(-/-) mice...
September 25, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28944228/clostridium-tertium-peritonitis-and-concurrent-bacteremia-in-a-patient-with-a-history-of-alcoholic-cirrhosis
#2
S Scott Sutton, Mark Jumper, Ansal Shah, Babatunde Edun
Spontaneous bacterial peritonitis (SBP) is a recognized cause of morbidity and mortality in cirrhotic patients. Enterobacteriaceae have been isolated from the majority of peritonitis cases and the gram negative aerobe Escherichia coli is the most commonly isolated organism. Anaerobic organisms are rarely isolated because of the high oxygen tension in ascetic fluid. We report a patient with a history of alcoholic cirrhosis who developed SBP and concurrent bacteremia with the anaerobe Clostridium tertium. The patient was successfully treated with intravenous antibiotics and was discharged home on oral ciprofloxacin...
July 2017: Journal of Investigative Medicine High Impact Case Reports
https://www.readbyqxmd.com/read/28944147/sigmoid-volvulus-in-young-patients-%C3%A4-new-twist-on-an-old-diagnosis
#3
Moaziz Sarfaraz, Syeda Rana Hasan, Shahid Lateef
According to the literature, sigmoid volvulus typically develops in patients of an older age with co-morbidities such as a psychiatric illness or a bed-bound chronic illness. Recent reports suggest that it should also be considered in young individuals without any preceding medical history. Abdominal roentgenography is a cheap and effective diagnostic modality that can avoid a delay in diagnosis. The treatment of colonic volvulus remains controversial and relies upon the procedure selected and the most appropriate therapeutic approach in terms of the clinical status of the patient, the location of the problem, the suspected existence or identification of peritonitis, bowel viability, and the expertise of the surgical team...
August 2017: Intractable & Rare Diseases Research
https://www.readbyqxmd.com/read/28944070/rifaximin-versus-norfloxacin-for-prevention-of-spontaneous-bacterial-peritonitis-a-systematic-review
#4
Gurpartap S Sidhu, Andrew Go, Bashar M Attar, Hemant R Mutneja, Shilpa Arora, Sanjay A Patel
AIM: The aim of this systematic review is to evaluate the efficacy and safety of rifaximin in the prophylaxis of spontaneous bacterial peritonitis (SBP) as compared with norfloxacin. METHODS: We searched MEDLINE, CINAHL, Google Scholar and Cochrane databases from inception to January 2017. Reference lists of articles as well as conference proceedings were manually screened. We included studies that recruited patients with cirrhosis and ascites who met the criteria for primary or secondary SBP prophylaxis as defined by the European Association for the Study of the Liver and American Association for the Study of Liver Diseases...
2017: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/28943914/metastatic-gastric-cancer-from-breast-carcinoma-a-report-of-78-cases
#5
Liang Xu, Shujing Liang, Ningning Yan, Le Zhang, Hailiang Gu, Xiaochun Fei, Yingchun Xu, Fengchun Zhang
The metastatic spread of breast carcinoma to the stomach is rare. There are a small number of previous studies that report metastases from the breast to the stomach and these provide limited information regarding this infrequent event. Consequently, the clinicopathological features, clinical outcomes and the optimal treatment for these patients remain to be elucidated. In the present study, 78 cases of gastric metastases from breast cancer, including the current case, were identified from previous studies between 1960 and 2015...
October 2017: Oncology Letters
https://www.readbyqxmd.com/read/28943826/the-use-of-daptomycin-to-treat-methicillin-resistant-staphylococcus-epidermidis-bacteremia-in-a-critically-ill-child-with-renal-failure
#6
Stephen Morris, Kate Gould, Lee P Ferguson
Daptomycin is excreted primarily unchanged by the kidney. Dosage regimens in children with renal failure remain to be determined. We report the case of an 8-year-old child with multiorgan failure undergoing continuous peritoneal dialysis, successfully treated with intravenous daptomycin for methicillin-resistant Staphylococcus epidermidis bacteremia. A dosage of 8 mg/kg every 48 hour was used. Plasma peak and trough concentrations of daptomycin were 68 mg/L and 14.6 mg/L, respectively, on day 6 of treatment...
July 2017: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/28943571/mycobacterium-wolinskyi-peritonitis-after-peritoneal-catheter-embedment-surgery
#7
Hiroyuki Fujikura, Kei Kasahara, Yoshihiko Ogawa, Nobuyasu Hirai, Seiya Yoshii, Shingo Yoshihara, Taku Ogawa, Shinsuke Yonekawa, Natsuko Imakita, Yuichi Nishioka, Tatsuo Yoneda, Katsunori Yoshida, Ken-Ichi Samejima, Kaori Tanabe, Yoshihiko Saito, Hisakazu Yano, Keiichi Mikasa
Mycobacterium wolinskyi belongs to the Mycobacterium smegmatis group, which comprises rapidly growing non-tuberculous mycobacteria. The number of case reports on M. wolinskyi infections associated with postoperative wounds has increased in recent years. We herein report a case of peritonitis due to M. wolinskyi after peritoneal catheter embedment surgery. Identification was achieved based on 16S ribosomal RNA and rpoB gene sequencing of the isolate. The patient recovered following catheter removal and treatment with levofloxacin and minocycline for one month...
September 25, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28943439/a-homogalacturonan-from-hippophae-rhamnoides-l-berries-enhance-immunomodulatory-activity-through-tlr4-myd88-pathway-mediated-activation-of-macrophages
#8
Hailiang Wang, Hongtao Bi, Tingting Gao, Bin Zhao, Weihua Ni, Jun Liu
Our previous study isolated a natural high-methoxyl homogalacturonan (HRWP-A) from Hippophae rhamnoides and showed antitumor activity in vivo. In this study, the immunomodulatory activity and mechanisms of action of HRWP-A were further investigated. RESULTS: showed that HRWP-A could recover the body condition and activated macrophage in Cyclophosphamide (CTX)-induced immunosuppressed mice. Further, we investigated the possible mechanism underlying the effects of HRWP-A on mouse peritoneal macrophages...
September 21, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28943395/pathological-diaphragmatic-invasion-by-colorectal-liver-metastases-is-associated-with-ras-mutation-peritoneal-recurrence-and-worse-survival
#9
Masayuki Okuno, Claire Gourmard, Takashi Mizuno, Kiyohiko Omichi, Ching-Wei D Tzeng, Yun Shin Chun, Jeffrey E Lee, Jean-Nicolas Vauthey, Claudius Conrad
BACKGROUND: Risk factors for pathological diaphragmatic invasion from colorectal liver metastases (CRLM) and differences in recurrence patterns and survival between patients with true pathological diaphragmatic invasion versus inflammatory adhesions only remain poorly understood. This study aimed at identifying risk factors for and survival impact of pathological diaphragmatic invasion in patients with CRLM. METHODS: Patients with CRLM who underwent hepatectomy with or without diaphragmatic resection from 1998 to 2015 were retrospectively analyzed...
September 21, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/28943323/hartmann-s-procedure-or-primary-anastomosis-for-generalized-peritonitis-due-to-perforated-diverticulitis-a-prospective-multicenter-randomized-trial-diverti
#10
Valerie Bridoux, Jean Marc Regimbeau, Mehdi Ouaissi, Muriel Mathonnet, Francois Mauvais, Estelle Houivet, Lilian Schwarz, Diane Mege, Igor Sielezneff, Charles Sabbagh, Jean Jacques Tuech
BACKGROUND: About 25% of patients with acute diverticulitis require emergency intervention. Currently, most patients with diverticular peritonitis undergo a Hartmann's procedure. Our objective was to assess whether primary anastomosis (PA) with a diverting stoma allows lower mortality than Hartmann's procedure (HP) inpatients with diverticular peritonitis. STUDY DESIGN: Multicenter randomized controlled trial conducted between June 2008 and May 2012: the DIVERTI study ...
September 21, 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/28943000/histological-and-immunohistochemical-study-of-cardiac-telocytes-in-a-rat-model-of-isoproterenol-induced-myocardial-infarction-with-a-reference-to-the-effect-of-grape-seed-extract
#11
Mai Salah Nour, Nahla Reda Sarhan, Shireen A Mazroa, Salwa A Gawish
INTRODUCTION: Cardiac telocytes (TCs) represent a unique type of cells that make a supportive network for stem cells that contribute in cardiac renewal, but their role during myocardial infarction (MI) is not clear. Grape seed extract (GSE) is a powerful natural antioxidant. AIM OF THE WORK: Quantitative study of cardiac TCs in a rat model of Isoproterenol (ISO)-induced MI, and to evaluate the effect of GSE on TCs and MI progression. MATERIALS AND METHODS: Seventy adult male albino rats were assigned into 4 groups; group I; control rats, group II received GSE (100mg/kg/day) dissolved in distilled water orally, group III received 2 intra-peritoneal injections of 85mg/kg ISO dissolved in saline on 14th and 15th day to induce MI, and group IV received GSE and ISO...
September 21, 2017: Acta Histochemica
https://www.readbyqxmd.com/read/28942945/polysaccharides-derived-from-ganoderma-lucidum-fungus-mycelia-ameliorate-indomethacin-induced-small-intestinal-injury-via-induction-of-gm-csf-from-macrophages
#12
Kenta Nagai, Yoshitaka Ueno, Shinji Tanaka, Ryohei Hayashi, Kei Shinagawa, Kazuaki Chayama
Non-steroidal anti-inflammatory drugs often cause ulcers in the human small intestine, but few effective agents exist to treat such injury. Ganoderma lucidum Karst, also known as "Reishi" or "Lingzhi", is a mushroom. We previously reported that a water-soluble extract from G. lucidum fungus mycelia (MAK) has anti-inflammatory effects in murine colitis induced by trinitrobenzene sulfonic acid, and induction of granulocyte macrophage colony-stimulating factor (GM-CSF) by MAK may provide anti-inflammatory effects...
August 4, 2017: Cellular Immunology
https://www.readbyqxmd.com/read/28942506/production-of-tiger-puffer-takifugu-rubripes-offspring-from-triploid-grass-puffer-takifugu-niphobles-parents
#13
Masaomi Hamasaki, Yutaka Takeuchi, Ryosuke Yazawa, Souta Yoshikawa, Kazushi Kadomura, Toshiyuki Yamada, Kadoo Miyaki, Kiyoshi Kikuchi, Goro Yoshizaki
The tiger puffer Takifugu rubripes is one of the most popular aquacultural fish; however, there are two major obstacles to selective breeding. First, they have a long generation time of 2 or 3 years until maturation. Second, the parental tiger puffer has a body size (2-5 kg) much larger than average market size (0.6-1.0 kg). The grass puffer Takifugu niphobles is closely related to the tiger puffer and matures in half the time. Furthermore, grass puffer can be reared in small areas since their maturation weight is about 1/150 that of mature tiger puffer...
September 23, 2017: Marine Biotechnology
https://www.readbyqxmd.com/read/28942415/confusion-and-abdominal-symptoms-following-a-rugby-tackle
#14
Demetris Ioannides, Madeleine Davies, Stefan Kluzek
A 19-year-old man was sent to the emergency department following a pitch-side assessment for suspected concussion, unexplained upper abdominal tenderness and vomiting, following a high-impact tackle during a rugby match. A Focussed Assessment with Sonography for Trauma (FAST) scan performed in the emergency department suggested intra-abdominal free fluid, and subsequent head and abdominal CT imaging showed no intracranial lesion but confirmed a significant haemoperitoneum due to large splenic tear and bleeding...
September 23, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28942023/mirna-23-regulates-high-glucose-induced-epithelial-to-mesenchymal-transition-in-human-mesotheial-peritoneal-cells-by-targeting-vdr
#15
Lina Yang, Yi Fan, Xiuli Zhang, Jianfei Ma
Epithelial-mesenchymal transition(EMT) is the main reason for peritoneal fibrosis and the mechanism underlying peritoneal EMT were extensively studied in recent years. Recent researches showed that miRNAs were so important in the development of organ EMT and fibrosis, the role of microRNAs on peritoneal dialysis have also been studied. In the current study, we investigated microRNA-23(miR-23) expression in high glucose(HG) induced EMT in human mesotheial peritoneal cells(HPMCs). We found that HG promoted EMT, which was characterized by the upregulation of mesenchymal markers α-SMA and FN and downregulation of epithelial marker E-cadherin...
September 20, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28940402/diffuse-peritoneal-mesothelioma-a-case-series-of-62-patients-including-paraoccupational-exposures-to-chrysotile-asbestos
#16
Richard L Kradin, George Eng, David C Christiani
BACKGROUND: Diffuse peritoneal malignant mesothelioma (DPM) is caused by exposure to asbestos. The medical literature has linked DPM primarily to high levels of asbestos exposure, in particular amosite. Controversy persists as to whether chrysotile is capable of causing DPM, especially when exposures are paraoccupational. METHODS: Sixty-two subjects (51 men, 11 women) with DPM were reviewed in medical-legal consultation with deposition and product identification evidence...
September 22, 2017: American Journal of Industrial Medicine
https://www.readbyqxmd.com/read/28940384/lipid-homeostasis-and-inflammatory-activation-are-disturbed-in-classically-activated-macrophages-with-peroxisomal-%C3%AE-oxidation-deficiency
#17
Ivana Geric, Yulia Y Tyurina, Olga Krysko, Dmitri V Krysko, Evelyn De Schryver, Valerian E Kagan, Paul P Van Veldhoven, Myriam Baes, Simon Verheijden
Macrophage activation is characterized by pronounced metabolic adaptation. Classically activated macrophages show decreased rates of mitochondrial fatty acid oxidation and oxidative phosphorylation and acquire a glycolytic state together with their pro-inflammatory phenotype. In contrast, alternatively activated macrophages require oxidative phosphorylation and mitochondrial fatty acid oxidation for their anti-inflammatory function. Although it is evident that mitochondrial metabolism is regulated during macrophage polarization and essential for macrophage function, little is known on the regulation and role of peroxisomal β-oxidation during macrophage activation...
September 22, 2017: Immunology
https://www.readbyqxmd.com/read/28940225/treatment-of-refractory-ascites-with-an-automated-low-flow-ascites-pump-in-patients-with-cirrhosis
#18
G Stirnimann, T Berg, L Spahr, S Zeuzem, S McPherson, F Lammert, F Storni, V Banz, J Babatz, V Vargas, A Geier, A Stallmach, C Engelmann, C Trepte, J Capel, A De Gottardi
BACKGROUND: Refractory ascites (RA) is a frequent complication of cirrhosis, requiring large volume paracentesis or placement of a transjugular intrahepatic portosystemic shunt (TIPSS). The automated low-flow ascites pump (alfapump, Sequana Medical AG, Zurich, Switzerland) is an innovative treatment option for patients with RA. AIM: To assess safety and efficacy of this treatment in patients with a contraindication to TIPSS. METHODS: Fifty-six patients (43 males; mean age 62 years) from centres in Germany, Switzerland, UK and Spain were included and followed for up to 24 months...
September 21, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28939643/role-of-g-protein-coupled-receptor-kinase-6-in-escherichia-coli-lung-infection-model-in-mice
#19
Taehyung Lee, Nandakumar Packiriswamy, Eunhee Lee, Peter C Lucas, Laura R McCabe, Narayanan Parameswaran
G protein-coupled receptor kinase-6 (GRK6) is a serine/threonine kinase that is important in inflammatory processes. In this study, we examined the role of GRK6 in Escherichia coli (E. coli)-induced lung infection and inflammation using GRK6 knockout (KO) and wild type (WT) mice. Intratracheal instillation of E. coli significantly enhanced bacterial load in the bronchoalveolar lavage (BAL) of KO compared to WT mice. Reduced bacterial clearance in the KO mice was not due to an intrinsic defect in neutrophil phagocytosis or killing but as a result of reduced neutrophil numbers in the KO BAL...
September 22, 2017: Physiological Genomics
https://www.readbyqxmd.com/read/28939555/a-novel-therapeutic-strategy-for-pancreatic-cancer-targeting-cell-surface-glycan-using-rbc2lc-n-lectin-drug-conjugate-ldc
#20
Osamu Shimomura, Tatsuya Oda, Hiroaki Tateno, Yusuke Ozawa, Sota Kimura, Shingo Sakashita, Masayuki Noguchi, Jun Hirabayashi, Makoto Asashima, Nobuhiro Ohkohchi
Various cancers, including pancreatic ductal adenocarcinoma (PDAC), remain intractable even with costly tumour-targeting antibody drugs. Because the outermost coatings of cancer cells are composed of cell-specific glycan layers (glycocalyx), lectins, proteins with glycan-binding potential, were evaluated for possible use as drug carriers in PDAC treatment. A human PDAC cell line with well-to-moderately differentiated properties (Capan-1) was subjected to lectin microarray analysis to identify specific lectin-glycan pairs...
September 22, 2017: Molecular Cancer Therapeutics
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