Hannah Zogg, Rajan Singh, Se Eun Ha, Zhuqing Wang, Byungchang Jin, Mariah Ha, Mirabel Dafinone, Tylar Batalon, Nicholas Hoberg, Sandra Poudrier, Linda Nguyen, Wei Yan, Brian T Layden, Lara R Dugas, Kenton M Sanders, Seungil Ro
BACKGROUND/AIM: Diabetes has substantive co-occurrence with disorders of gut-brain interactions (DGBIs). The pathophysiological and molecular mechanisms linking diabetes and DGBIs are unclear. MicroRNAs (miRNAs) are key regulators of diabetes and gut dysmotility. We investigated whether impaired gut barrier function is regulated by a key miRNA, miR-10b-5p, linking diabetes and gut dysmotility. METHODS: We created a new mouse line using the Mb3Cas12a/Mb3Cpf1 endonuclease to delete mir-10b globally...
October 2023: United European Gastroenterology Journal