keyword
https://read.qxmd.com/read/38510015/pdp-type-brain-tumor-in-association-with-multiple-endocrine-neoplasia-type-1
#21
Halldór Bjarki Einarsson, Anja Lisbeth Frederiksen, Inge Soekilde Pedersen, Marianne Schmidt Ettrup, Martin Wirenfeldt, Henning Boldt, Nina Nguyen, Marianne Skovsager Andersen, Carsten Reidies Bjarkam, Frantz Rom Poulsen
Multiple endocrine neoplasia type 1 (MEN1) is a rare autosomal dominant syndrome caused by inactivating pathogenic variants in the tumor suppressor gene menin 1 on chromosome 11q13 (Falchetti et al., 2009). The syndrome is characterized by neoplasia in two or more endocrine glands and has a high degree of penetrance. Pathogenic germline multiple neoplasia type 1 variants primarily result in neoplasia affecting the parathyroid glands, the pancreatic islet cells, and the anterior pituitary in combination. Primary hyperparathyroidism is the most common pathological manifestation of the syndrome, followed by pancreatic neuroendocrine tumors...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38508520/primary-cilia-as-a-tumor-marker-in-pituitary-neuroendocrine-tumors
#22
JOURNAL ARTICLE
Rebeca Martínez-Hernández, Ana Serrano-Somavilla, Raul Fernández-Contreras, Cristina Sanchez-Guerrero, Nuria Sánchez de la Blanca, Pablo Sacristán-Gómez, Fernando Sebastian-Valles, Miguel Sampedro-Núñez, Javier Fraga, María Calatayud, Almudena Vicente, Gonzalo García-de-Casasola, Ancor Sanz-García, Marta Araujo-Castro, Ignacio Ruz-Caracuel, Manel Puig-Domingo, Mónica Marazuela
Pituitary neuroendocrine tumors (PitNETs) account for approximately 15% of all intracranial neoplasms. Although they usually appear to be benign, some tumors display worse behavior, displaying rapid growth, invasion, refractoriness to treatment, and recurrence. Increasing evidence supports the role of primary cilia (PC) in regulating cancer development. Here, we showed that PC are significantly increased in PitNETs and are associated with increased tumor invasion and recurrence. Serial electron micrographs of PITNETs demonstrated different ciliation phenotypes (dot-like versus normal-like cilia) that represented PC at different stages of ciliogenesis...
March 18, 2024: Modern Pathology
https://read.qxmd.com/read/38505563/transcriptome-analysis-reveals-distinct-patterns-between-the-invasive-and-noninvasive-pituitary-neuroendocrine-tumors
#23
JOURNAL ARTICLE
Jelena Jotanovic, Abdellah Tebani, Neda Hekmati, Åsa Sivertsson, Cecilia Lindskog, Mathias Uhlèn, Olafur Gudjonsson, Erika Tsatsaris, Britt Edén Engström, Johan Wikström, Fredrik Pontén, Olivera Casar-Borota
Although most pituitary neuroendocrine tumors (PitNETs)/pituitary adenomas remain intrasellar, a significant proportion of tumors show parasellar invasive growth and 6% to 8% infiltrate the bone structures, thus affecting the prognosis. There is an unmet need to identify novel markers that can predict the parasellar growth of PitNETs. Furthermore, mechanisms that regulate bone invasiveness of PitNETs and factors related to tumor vascularization are largely unknown. We used genome-wide mRNA analysis in a cohort of 77 patients with PitNETs of different types to explore the differences in gene expression patterns between invasive and noninvasive tumors with respect to the parasellar growth and regarding the rare phenomenon of bone invasiveness...
March 12, 2024: Journal of the Endocrine Society
https://read.qxmd.com/read/38503992/excess-mortality-in-patients-with-non-functioning-pituitary-adenoma-a-systematic-review-and-meta-analysis
#24
REVIEW
F Bioletto, M Sibilla, V Gasco, E Ghigo, S Grottoli
BACKGROUND: Patients with non-functioning pituitary adenoma (NFPA) often present with a variety of clinical manifestations and comorbidities, mainly determined by the local mass effect of the tumor and by hypopituitarism. Whether this has an impact on overall mortality, however, is still unclear. METHODS: PubMed/Medline, EMBASE, and Cochrane Library databases were systematically searched until May 2023 for studies reporting data either about standardized mortality ratios (SMRs) or about predictors of mortality in patients with NFPA...
March 19, 2024: Journal of Endocrinological Investigation
https://read.qxmd.com/read/38499816/prolactin-secreting-tumors-dopamine-agonists-and-pregnancy-a-longitudinal-experience-of-a-tertiary-neuroendocrine-center
#25
JOURNAL ARTICLE
Nunzia Prencipe, Chiara Bona, Daniela Cuboni, Alessandro Maria Berton, Fabio Bioletto, Emanuele Varaldo, Luigi Simone Aversa, Michela Sibilla, Valentina Gasco, Ezio Ghigo, Silvia Grottoli
PURPOSE: Prolactin (PRL)-secreting tumours are associated with infertility and can be reverted by dopamine agonist (DA) therapy. The suspension of DA is recommended once pregnancy is established, as all DAs cross the placenta. The aim of the study was to evaluate the rate of maternal-foetal complications in women treated with cabergoline (CAB) or bromocriptine (BRM) for prolactinoma during gestation and the effect of pregnancy on prolactinoma progression. METHODS: This was a retrospective observational study involving 43 women affected by prolactinoma who became pregnant during therapy with CAB or BRM for a total of 58 pregnancies...
March 18, 2024: Pituitary
https://read.qxmd.com/read/38498406/combined-simultaneous-transsphenoidal-and-transcranial-regimen-improves-surgical-outcomes-in-complex-giant-pituitary-adenomas-a-longitudinal-retrospective-cohort-study
#26
JOURNAL ARTICLE
Nidan Qiao, Wei Gao, Xingli Deng, Tao Xin, Gangli Zhang, Nan Wu, Pan Wang, Yunke Bi, Zixiang Cong, Zhiyi Zhou, Junjun Li, Shengyu Sun, Meng Li, Wenlong Tang, Xiaorong Yan, Wenxiong Wang, Wenjin Chou, Shun Yao, Zhao Ye, Zengyi Ma, Xiang Zhou, Xiaoyun Cao, Ming Shen, Xuefei Shou, Zhaoyun Zhang, Zhenyu Wu, Liangzhao Chu, Yongming Qiu, Hui Ma, Anhua Wu, Chiyuan Ma, Meiqing Lou, Changzhen Jiang, Yongfei Wang, Yao Zhao
BACKGROUND: Surgical treatment of complex giant pituitary adenomas (GPAs) presents significant challenges. The efficacy and safety of combining transsphenoidal and transcranial approaches for these tumors remain controversial. In this largest cohort of patients with complex GPAs, we compared the surgical outcomes between those undergoing a combined regimen and a non-combined regimen. We also examined the differences in risks of complications, costs, and logistics between the two groups, which might offer valuable information for the appropriate management of these patients...
March 18, 2024: International Journal of Surgery
https://read.qxmd.com/read/38495108/editorial-pituitary-neuroendocrine-tumors-tumorigenesis-pathogenesis-diagnosis-and-targeted-therapy-from-bench-to-bedside
#27
EDITORIAL
Hao Lyu, De Ling Li, Yi Rong Yang, Yong Yao, Hui Wang, Guo Dong Huang
No abstract text is available yet for this article.
2024: Frontiers in Neuroscience
https://read.qxmd.com/read/38494939/design-and-development-of-hypertuned-deep-learning-frameworks-for-detection-and-severity-grading-of-brain-tumor-using-medical-brain-mr-images
#28
JOURNAL ARTICLE
Neha Bhardwaj, Meenakshi Sood, Sandeep Singh Gill
BACKGROUND: Brain tumor is a grave illness causing worldwide fatalities. The current detection methods for brain tumors are manual, invasive, and rely on histopathological analysis. Determining the type of brain tumor after its detection relies on biopsy measures and involves human subjectivity. The use of automated CAD techniques for brain tumor detection and classification can overcome these drawbacks. OBJECTIVE: The paper aims to create two deep learning-based CAD frameworks for automatic detection and severity grading of brain tumors - the first model for brain tumor detection in brain MR images and model 2 for the classification of tumors into three types: Glioma, Meningioma, and Pituitary based on severity grading...
March 15, 2024: Current medical imaging
https://read.qxmd.com/read/38487343/relevance-of-mutations-in-protein-deubiquitinases-genes-and-tp53-in-corticotroph-pituitary-tumors
#29
JOURNAL ARTICLE
Monika Pękul, Magdalena Szczepaniak, Paulina Kober, Natalia Rusetska, Beata J Mossakowska, Szymon Baluszek, Artur Kowalik, Maria Maksymowicz, Grzegorz Zieliński, Jacek Kunicki, Przemysław Witek, Mateusz Bujko
INTRODUCTION: Corticotroph pituitary neuroendocrine tumors (PitNETs) develop from ACTH-producing cells. They commonly cause Cushing's disease (CD), however, some remain clinically silent. Recurrent USP8 , USP48 , BRAF and TP53 mutations occur in corticotroph PitNETs. The aim of our study was to determine frequency and relevance of these mutations in a possibly large series of corticotroph PitNETs. METHODS: Study included 147 patients (100 CD and 47 silent tumors) that were screened for hot-spot mutations in USP8 , USP48 and BRAF with Sanger sequencing, while 128 of these patients were screened for TP53 mutations with next generation sequencing and immunohistochemistry...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38487320/clinical-study-on-the-selection-of-endoscopes-and-microscopes-for-transsphenoidal-surgery-of-non-aggressive-pituitary-macroadenoma-and-microadenoma-and-the-influencing-factors-of-hyposmia-after-endoscopic-transsphenoidal-surgery
#30
JOURNAL ARTICLE
Fanyi Kong, Weiping Cheng, Qingyang Zhan
BACKGROUND AND OBJECTIVE: Transsphenoidal surgery, including endoscopic and microscopic resection, is the first choice of treatment for pituitary tumors. With the widespread application of neuroendoscopy in recent decades, there has been a trend to replace microscopes. In clinical practice, we have found that in transsphenoidal surgery for non-invasive microadenomas and macroadenomas, microscopy can achieve a higher total resection rate, shorter operation time, lower incidence of postoperative complications, and faster recovery of olfaction...
2024: Frontiers in Neurology
https://read.qxmd.com/read/38487122/high-grade-atypical-teratoid-rhabdoid-tumor-in-the-pituitary-region
#31
Vincent S Alexander, Michael Ernst, Wang L Cheung, Alyssa N Obermiller, Catherine Mercado, Hermes Garcia, Kavita M Pattani
Atypical teratoid/rhabdoid tumors (AT/RTs) are embryological tumors of the central nervous system (CNS). They are typically found in children, with rare presentations in adults. We describe the presentation of an AT/RT in the pituitary region of a 37-year-old female. The patient presented with a two-week history of intractable cephalgia with sudden onset of monocular diplopia and left-sided cranial nerve VI palsy. The patient underwent transsphenoidal resection of their mass, which revealed the diagnosis...
February 2024: Curēus
https://read.qxmd.com/read/38484372/-brain-tumor-surgery-in-adults
#32
REVIEW
György Attila Bagó, Gergő Dávid Nagy
Despite the advanced medical and radiation therapy, the role of surgical resection of brain neoplasms still remains indisputable. The maximal safe resection of benign brain tumors may result in complete recovery of the patient. Surgery of malignant tumors can resolve mass effect, improve the neurological condition of the patient providing the possibility for further complex oncotherapy based on molecular level histopathology results. The advances in technical and multidisciplinary environment of brain tumor surgery facilitate more radical and safer resection resulting in better outcomes and preservation of quality of life, even in case of tumors which were considered inoperable until recently...
March 14, 2024: Magyar Onkologia
https://read.qxmd.com/read/38482414/-hes1-induces-itpr1-mediated-autophagy-to-exert-anti-metastatic-effects-in-pituitary-adenomas
#33
JOURNAL ARTICLE
Chunjian Qiu, Yao Yao, Suqin Hu, Yixin Xu
BACKGROUND: Pituitary adenomas (PAs) are prevalent intracranial tumors necessitating a comprehensive exploration of their molecular intricacies. This study delved into the molecular interactions among HES1 (hairy and enhancer of split 1), ITPR1 (inositol 1,4,5-trisphosphate receptor, type 1), and autophagy to elucidate their contributions to PA progression. METHODS: Our in-depth bioinformatics analysis identified ITPR1 as a central hub gene in the PA-associated dataset...
February 29, 2024: Translational Cancer Research
https://read.qxmd.com/read/38482253/upregulated-expression-of-pttg1-is-associated-with-progression-of-pancreatic-cancer
#34
JOURNAL ARTICLE
Yu He, Zhangyan Du, Honghua Peng, Abhinav V Reddy, Peiguo Cao
BACKGROUND: Pancreatic cancer (PC) is an aggressive disease with a very poor prognosis. The insidious onset, rapid progression, and resistance to conventional therapies mark the imperious need for novel biomarkers and therapeutic targets. The pituitary tumor transforming gene 1 ( PTTG1 ), implicated in tumorigenesis and cellular transformation, has been studied in various cancers, however, its role and mechanisms in PC remain to be elucidated for better understanding the disease pathology and in enhancing patient management strategies...
February 29, 2024: Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/38481440/case-report-management-of-pediatric-gigantism-caused-by-the-tadopathy-x-linked-acrogigantism
#35
Manuela Caruso, Diego Mazzatenta, Sofia Asioli, Giuseppe Costanza, Giampaolo Trivellin, Martin Franke, Dayana Abboud, Julien Hanson, Véronique Raverot, Patrick Pétrossians, Albert Beckers, Marco Cappa, Adrian F Daly
X-linked acrogigantism (X-LAG) is a rare form of pituitary gigantism that is associated with growth hormone (GH) and prolactin-secreting pituitary adenomas/pituitary neuroendocrine tumors (PitNETs) that develop in infancy. It is caused by a duplication on chromosome Xq26.3 that leads to the misexpression of the gene GPR101 , a constitutively active stimulator of pituitary GH and prolactin secretion. GPR101 normally exists within its own topologically associating domain (TAD) and is insulated from surrounding regulatory elements...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38480833/development-and-prospective-validation-of-an-artificial-intelligence-based-smartphone-app-for-rapid-intraoperative-pituitary-adenoma-identification
#36
JOURNAL ARTICLE
Rabih Bou-Nassif, Anne S Reiner, Matthew Pease, Tejus Bale, Marc A Cohen, Marc Rosenblum, Viviane Tabar
BACKGROUND: Intraoperative pathology consultation plays a crucial role in tumor surgery. The ability to accurately and rapidly distinguish tumor from normal tissue can greatly impact intraoperative surgical oncology management. However, this is dependent on the availability of a specialized pathologist for a reliable diagnosis. We developed and prospectively validated an artificial intelligence-based smartphone app capable of differentiating between pituitary adenoma and normal pituitary gland using stimulated Raman histology, almost instantly...
March 13, 2024: Commun Med (Lond)
https://read.qxmd.com/read/38479600/the-aryl-hydrocarbon-receptor-interacting-protein-in-cancer-and-immunity-beyond-a-chaperone-protein-for-the-dioxin-receptor
#37
REVIEW
Sarah A Kazzaz, John Tawil, Edward W Harhaj
The aryl hydrocarbon receptor (AhR) interacting protein (AIP) is a ubiquitously expressed, immunophilin-like protein best known for its role as a co-chaperone in the AhR-AIP-Hsp90 cytoplasmic complex. In addition to regulating AhR and the xenobiotic response, AIP has been linked to various aspects of cancer and immunity that will be the focus of this review article. Loss of function AIP mutations are associated with pituitary adenomas, suggesting that AIP acts as a tumor suppressor in the pituitary gland. However, the tumor suppressor mechanisms of AIP remain unclear, and AIP can exert oncogenic functions in other tissues...
March 11, 2024: Journal of Biological Chemistry
https://read.qxmd.com/read/38476426/factors-predicting-outcomes-of-endoscopic-endonasal-approach-in-craniopharyngioma-patients
#38
JOURNAL ARTICLE
Chin Taweesomboonyat, Raywat Noiphithak, Pree Nimmannitya, Sakchai Sae-Heng
OBJECTIVES: Endoscopic endonasal approach (EEA) is commonly used for resection of craniopharyngioma (CP). Treatment outcomes of EEA for CP were related to numerous factors; however, they have been evaluated in few studies. The objective of this study is to investigate factors associated with the outcomes of CP following this operation. MATERIALS AND METHODS: The records of patients with CP, who underwent EEA at our institution from January 2014 to June 2022, were retrospectively reviewed...
2024: Journal of Neurosciences in Rural Practice
https://read.qxmd.com/read/38476418/synchronous-presentation-of-prolactinoma-and-supratentorial-tanycytic-ependymoma
#39
Jishnu Narayanan Nair, Rav Tej Bathala, Visvanathan Krishnaswamy, Shriraam Mahadevan
Tanycytic ependymomas mostly occur in the spinal cord and it is the rarest histological subtype of ependymoma. A 29-year-old male was referred from the infertility clinic after serum prolactin levels were found to be elevated. Magnetic resonance imaging (MRI) brain showed an irregular necrotic lesion in the periventricular region of the left parietal lobe which had an intraventricular component and associated perilesional edema. In addition, a sellar mass with suprasellar extension was also found on the MRI...
2024: Journal of Neurosciences in Rural Practice
https://read.qxmd.com/read/38475950/mir-362-3p-inhibited-the-invasion-and-metastasis-of-oral-squamous-cell-carcinoma-cells-by-targeting-the-regulation-of-pituitary-tumor-transforming-gene-1
#40
JOURNAL ARTICLE
Xiao Ding, Jiawen Chen, Pengyu Qu, Chenyu Sun, Hongli Li, Wenting Hu, Xin Fan
OBJECTIVES: This study aimed to explore the effect of pituitary tumor-transforming gene 1 (PTT-G1) on the invasion and proliferation of oral squamous cell carcinoma (OSCC) cell lines under the action of miR-362-3p. METHODS: The bioinformatics online database was used to query the expression of PTTG1 in head and neck squamous cell carcinoma (HNSCC). The expression of PTTG1 in the Cal-27, HN-30, and HOK cell lines was detected by Western blot. A wound-healing assay was used to determine the effect of PTTG1 on the migration ability of the OSCC cells...
February 1, 2024: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
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