keyword
https://read.qxmd.com/read/38535157/pituitary-adenoma-in-the-philippines-a-scoping-review-on-the-treatment-gaps-challenges-and-current-state-of-care
#1
REVIEW
Mykha Marie B Tabuzo, Mary Angeline Luz U Hernandez, Annabell E Chua, Patricia D Maningat, Harold Henrison C Chiu, Roland Dominic G Jamora
BACKGROUND: Pituitary adenomas are benign brain tumors that impose a heavy burden on patients worldwide. The local burden of disease is yet to be established due to scarcity of data. In line with this, this study aims to present the challenges and gaps in the treatment of pituitary adenomas in the Philippines. METHODS: A scoping review of available relevant literature on epidemiology, clinical experience with treatment, health financing, and healthcare delivery system based on the Preferred Reporting Items for Systematic reviews and Meta-analysis guidelines extension for Scoping Reviews was conducted...
March 19, 2024: Medical Sciences: Open Access Journal
https://read.qxmd.com/read/38534441/a-study-of-alternative-trka-splicing-identifies-trkaiii-as-a-novel-potentially-targetable-participant-in-pitnet-progression
#2
JOURNAL ARTICLE
Maddalena Sbaffone, Marie-Lise Jaffrain-Rea, Lucia Cappabianca, Francesca Carbonara, Francesca Gianno, Tiziana Feola, Marianna Ruggieri, Veronica Zelli, Rita Maccarone, Stefano Guadagni, Marco Clementi, Antonietta Arcella, Vincenzo Esposito, Giulia Carozza, Ilaria Martelli, Antonietta Rosella Farina, Andrew Reay Mackay
Pituitary neuroendocrine tumors (PitNETs) are generally benign but comprise an aggressive, invasive, therapy-resistant, metastatic subset, underpinning a need for novel therapeutic targets. PitNETs exhibit low mutation rates but are associated with conditions linked to alternative splicing, an alternative oncogene pathway activation mechanism. PitNETs express the neurotrophin receptor TrkA, which exhibits oncogenic alternative TrkAIII splicing in other neuroendocrine tumors. We, therefore, assessed whether TrkAIII splicing represents a potential oncogenic participant in PitNETs...
March 7, 2024: Biology
https://read.qxmd.com/read/38532895/cryptorchidism-and-puberty
#3
REVIEW
Wiwat Rodprasert, Helena E Virtanen, Jorma Toppari
Cryptorchidism is the condition in which one or both testes have not descended adequately into the scrotum. The congenital form of cryptorchidism is one of the most prevalent urogenital anomalies in male newborns. In the acquired form of cryptorchidism, the testis that was previously descended normally is no longer located in the scrotum. Cryptorchidism is associated with an increased risk of infertility and testicular germ cell tumors. However, data on pubertal progression are less well-established because of the limited number of studies...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38532073/long-term-pasireotide-therapy-in-acromegaly-extensive-real-life-experience-of-a-referral-center
#4
JOURNAL ARTICLE
R Pirchio, R S Auriemma, A Vergura, R Pivonello, A Colao
PURPOSE: Pasireotide is a novel therapeutic option for patients with acromegaly resistant to first-generation somatostatin receptor ligands. To date, real-life data are still scant, therefore, the aim of the current study is to evaluate the impact of long-term pasireotide therapy on disease control, pituitary tumor size, gluco-insulinemic and lipid profile in a real-life setting. METHODS: Retrospective study of data prospectively collected, evaluating hormonal, tumoral, and metabolic data of 28 patients with acromegaly administered with pasireotide in a pituitary tertiary referral center...
March 26, 2024: Journal of Endocrinological Investigation
https://read.qxmd.com/read/38528871/comparison-of-computed-tomography-perfusion-and-magnetic-resonance-dynamic-susceptibility-contrast-perfusion-weighted-imaging-in-canine-brain
#5
JOURNAL ARTICLE
Sangmin Lee, Soomin Park, Sungwha Hong, Soyeon Kim, Junghee Yoon, Jihye Choi
Brain perfusion allows for the evaluation of cerebral hemodynamics, particularly in brain infarcts and tumors. Computed tomography (CT) perfusion (CTP) provides reliable data; however, it has a limited scan field of view and radiation exposure. Magnetic resonance (MR) perfusion provides detailed imaging of small structures and a wide scan field of view. However, no study has compared CTP and MR perfusion and assessed the correlation between the perfusion parameters measured using CTP and MR perfusion. The aim of the present study was to assess the correlation and agreement of the cerebral perfusion derived from dynamic susceptibility contrast (DSC)-MRI and CTP in dogs...
2024: Frontiers in Veterinary Science
https://read.qxmd.com/read/38525119/the-cavernous-sinus-an-anatomic-study-with-clinical-implication
#6
JOURNAL ARTICLE
Myles L Pensak
OBJECTIVE: The management of lesions involving the cavernous sinus remains a formidable challenge. To optimize care for patients with tumors extending into this skull base region a detailed understanding of the surrounding osteology as well as neural and vascular relationships is requisite. This thesis examines the gross anatomy of the region and highlights important surgical implications drawn from these as well as previously published studies. METHODS: A review of the historical scientific, anatomic, clinical, and surgical literature extending to the present (1992) relating to the cavernous sinus has been performed and discussed...
April 2024: Laryngoscope Investigative Otolaryngology
https://read.qxmd.com/read/38522791/fully-endoscopic-minimally-invasive-trans-eyebrow-supraorbital-translaminar-approach-to-third-ventricle-craniopharyngiomas-technical-nuances-and-stepwise-illustrative-description
#7
JOURNAL ARTICLE
Mehdi Khaleghi, Kyle C Wu, Daniel M Prevedello
BACKGROUND: Traditional microsurgical approaches for addressing intraventricular craniopharyngioma pose limited access to the retrochiasmatic area and tumors with significant lateral or rostrocaudal extensions. Extended endoscopic endonasal approaches can effectively overcome many of limitations, yet they require a favorable angle between the optic chiasm and pituitary gland, as well as the involvement of the third ventricle floor by the tumor. METHODS: Herein, the authors describe the surgical nuances of a keyhole technique for resecting third ventricle craniopharyngiomas via a fully endoscopic minimally-invasive trans-eyebrow supraorbital translaminar approach (ESOTLA)...
March 22, 2024: World Neurosurgery
https://read.qxmd.com/read/38521837/changes-in-multi-modality-management-of-acromegaly-in-a-tertiary-centre-over-2-decades
#8
JOURNAL ARTICLE
V Amodru, N Sahakian, C Piazzola, R Appay, T Graillon, T Cuny, I Morange, F Albarel, M Vermalle, J Regis, H Dufour, T Brue, F Castinetti
PURPOSE: Acromegaly is a rare disease associated with chronic multisystem complications. New therapeutic strategies have emerged in the last decades, combining pituitary transsphenoidal surgery (TSS), radiotherapy or radiosurgery (RXT) and medical treatments. METHODS: This retrospective monocentric study focused on presentation, management and outcome of acromegaly patients diagnosed between 2000 and 2020, still followed up in 2020, with a minimum follow-up of 1 year, and comparison of the first vs...
March 23, 2024: Pituitary
https://read.qxmd.com/read/38518285/long-term-radiographic-and-endocrinological-outcomes-of-stereotactic-radiosurgery-for-recurrent-or-residual-nonfunctioning-pituitary-adenomas
#9
JOURNAL ARTICLE
Ahmed Shaaban, Chloé Dumot, Georgios Mantziaris, Sam Dayawansa, Selcuk Peker, Yavuz Samanci, Ahmed M Nabeel, Wael A Reda, Sameh R Tawadros, Khaled Abdel Karim, Amr M N El-Shehaby, Reem M Emad Eldin, Ahmed Ragab Abdelsalam, Roman Liscak, Jaromir May, Elad Mashiach, Fernando De Nigris Vasconcellos, Kenneth Bernstein, Douglas Kondziolka, Herwin Speckter, Ruben Mota, Anderson Brito, Shray K Bindal, Ajay Niranjan, L Dade Lunsford, Carolina Gesteira Benjamin, Timoteo Almeida, Jennifer Z Mao, David Mathieu, Jean-Nicolas Tourigny, Manjul Tripathi, Joshua David Palmer, Jennifer Matsui, Joseph Crooks, Rodney E Wegner, Matthew J Shepard, Jason P Sheehan
OBJECTIVE: Stereotactic radiosurgery (SRS) is used for the treatment of residual/recurrent nonfunctional pituitary adenoma (NFPA). The aim of this study was to evaluate the factors related to long-term tumor control and delayed endocrinopathies following SRS. METHODS: This retrospective, multicenter study included patients with recurrent/residual NFPA treated with single-fraction SRS; they were then divided into two arms. The first arm included patients with at least 5 years of radiographic follow-up and all patients with local tumor progression...
March 22, 2024: Journal of Neurosurgery
https://read.qxmd.com/read/38516477/evaluation-of-treatment-strategies-for-male-prolactin-secreting-pituitary-neuroendocrine-tumors
#10
JOURNAL ARTICLE
Norihiko Saito, Nozomi Hirai, Yuki Koyahara, Sho Sato, Yu Hiramoto, Satoshi Fujita, Haruo Nakayama, Morito Hayashi, Satoshi Iwabuchi
Prolactin-secreting pituitary neuroendocrine tumors (PitNETs) are more common in women. Male patients may also have few symptoms and have macroadenomas extending outside the sella turcica. This study aimed to report the results of cabergoline treatment in male patients with prolactin-secreting PitNET. The study included nine male patients aged 26-65 years (median, 46 years) diagnosed with prolactin-secreting PitNETs. The age at onset, prolactin values, tumor size, symptoms, and treatment were assessed. The mean prolactin value at the initial presentation was 2734...
February 2024: Curēus
https://read.qxmd.com/read/38516415/central-hyperthyroidism-due-to-an-ectopic-tsh-secreting-pituitary-tumor-a-case-report-and-literature-review
#11
Chonggui Zhu, Tong Liu, Haonan Yu, Lina Chang, Xiaona Zhang, Jia Yao, Geng Zhang, Qiusong Chen, Qing He, Ming Liu
Ectopic thyroid-stimulating hormone (TSH)-secreting tumors are extremely rare, with only 15 reported cases in the literature. Herein, we described a 60-year-old female patient with thyrotoxicosis and elevated or unsuppressed levels of TSH. Family history and laboratory and genetic tests did not support a diagnosis of resistance to thyroid hormone (RTH). Given the unsuppressed TSH, TSH-secreting tumor was suspected, and magnetic resonance imaging (MRI) of the pituitary gland was performed. Surprisingly, the MRI scans revealed a nodule in the nasopharynx rather than a pituitary tumor in the sella region...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38515047/predictive-value-of-cyst-tumor-volume-ratio-of-pituitary-adenoma-for-tumor-cell-proliferation
#12
JOURNAL ARTICLE
Jianwu Wu, Fangfang Zhang, Yinxing Huang, Liangfeng Wei, Tao Mei, Shousen Wang, Zihuan Zeng, Wei Wang
BACKGROUND: MRI has been widely used to predict the preoperative proliferative potential of pituitary adenoma (PA). However, the relationship between the cyst/tumor volume ratio (C/T ratio) and the proliferative potential of PA has not been reported. Herein, we determined the predictive value of the C/T ratio of PA for tumor cell proliferation. METHODS: The clinical data of 72 patients with PA and cystic change on MRI were retrospectively analyzed. PA volume, cyst volume, and C/T ratio were calculated...
March 21, 2024: BMC Medical Imaging
https://read.qxmd.com/read/38514521/customized-ventral-bony-and-dural-opening-in-the-transplanum-transtuberculum-and-transclival-variants-of-extended-endoscopic-endonasal-approach-to-suprasellar-craniopharyngiomas-an-approach-based-stepwise-cadaveric-dissection-and-clinical-applicability
#13
JOURNAL ARTICLE
Mehdi Khaleghi, Bradly Otto, Ricardo Carrau, Daniel M Prevedello
BACKGROUND: Optimal initial exposure through an extended endoscopic endonasal approach (EEA) for suprasellar craniopharyngiomas ensures safe and unrestricted surgical access while avoiding overexposure, which may prolong the procedure and increase neurovascular adverse events. METHOD: Here, the authors outline the surgical nuances of a customized bony and dural opening through the transplanum/transtuberculum and transclival variants of the extended EEA to suprasellar craniopharyngiomas based on the tumor-pituitary stalk relationship...
March 22, 2024: Acta Neurochirurgica
https://read.qxmd.com/read/38514124/-preoperative-simulation-of-endoscopic-endonasal-approach-for-craniopharyngiomas-or-tuberculum-sellae-meningiomas
#14
JOURNAL ARTICLE
Hiroyoshi Akutsu, Takeshi Hongo
Preoperative simulation for endoscopic endonasal approach(EEA)using computed tomography and magnetic resonance imaging evaluates tumor extension and the relationship between adjacent structure(the pituitary stalk, major vessels, and cranial nerves); therefore, preoperative planning of nasal procedure, skull base bony removal, and cranial base reconstruction are possible. Additionally, three-dimensional(3D)fusion image aids surgeons to visualize intraoperative 3D findings. These preoperative simulations are critical to avoid complications and predict pitfalls perioperatively...
March 2024: No Shinkei Geka. Neurological Surgery
https://read.qxmd.com/read/38514085/-18-f-fet-pet-mri-an-accurate-technique-for-detection-of-small-functional-pituitary-tumors
#15
JOURNAL ARTICLE
Ilanah J Pruis, Frederik A Verburg, Rutger K Balvers, Anita A Harteveld, Richard A Feelders, Meike W Vernooij, Marion Smits, Sebastian J C M M Neggers, Sophie E M Veldhuijzen van Zanten
Small functional pituitary tumors can cause severely disabling symptoms and early death. The gold standard diagnostic approach includes laboratory tests and MRI, with or without inferior petrosal sinus sampling (IPSS). In up to 40% of patients, however, the source of excess hormone production remains unidentified or uncertain. This excludes patients from surgical, Gamma Knife, and CyberKnife therapy and adversely affects overall cure rates. We here assess the diagnostic yield of O -(2-[18 F]fluoroethyl)-l-tyrosine ([18 F]FET) PET/MRI for detection of small functional pituitary tumors in these patients...
March 21, 2024: Journal of Nuclear Medicine
https://read.qxmd.com/read/38511043/endoscopic-sellar-defect-reconstruction-with-avascular-modified-gasket-seal-technique-for-sellar-tumors
#16
JOURNAL ARTICLE
Karthik Nagaraja Rao, Ripu Daman Arora, Anil Sharma, Rupa Mehta, Satish Satpute, Prajwal Dange, Nitin M Nagarkar
Watertight repair of the skull base defect is necessary during endonasal skull base surgery to avoid postoperative CSF leak (poCSFl) and consequent intracranial complications. Various techniques have been described for reconstructing sphenoid-sellar defects with varying success rates. We have described the immediate and long-term outcomes following the reconstruction of sphenoid-sellar defects with our technique. A retrospective analysis of the patients following transsphenoidal sellar surgery underwent barrier restoring reconstruction by multi-layered (inlay-overlay) with autologous thigh fat, fascia lata, fibrin glue, knitted collagen, and absorbable gelatin sponge (modified gasket seal technique)...
March 2024: Indian Journal of Surgical Oncology
https://read.qxmd.com/read/38510015/pdp-type-brain-tumor-in-association-with-multiple-endocrine-neoplasia-type-1
#17
Halldór Bjarki Einarsson, Anja Lisbeth Frederiksen, Inge Soekilde Pedersen, Marianne Schmidt Ettrup, Martin Wirenfeldt, Henning Boldt, Nina Nguyen, Marianne Skovsager Andersen, Carsten Reidies Bjarkam, Frantz Rom Poulsen
Multiple endocrine neoplasia type 1 (MEN1) is a rare autosomal dominant syndrome caused by inactivating pathogenic variants in the tumor suppressor gene menin 1 on chromosome 11q13 (Falchetti et al., 2009). The syndrome is characterized by neoplasia in two or more endocrine glands and has a high degree of penetrance. Pathogenic germline multiple neoplasia type 1 variants primarily result in neoplasia affecting the parathyroid glands, the pancreatic islet cells, and the anterior pituitary in combination. Primary hyperparathyroidism is the most common pathological manifestation of the syndrome, followed by pancreatic neuroendocrine tumors...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38508520/primary-cilia-as-a-tumor-marker-in-pituitary-neuroendocrine-tumors
#18
JOURNAL ARTICLE
Rebeca Martínez-Hernández, Ana Serrano-Somavilla, Raul Fernández-Contreras, Cristina Sanchez-Guerrero, Nuria Sánchez de la Blanca, Pablo Sacristán-Gómez, Fernando Sebastian-Valles, Miguel Sampedro-Núñez, Javier Fraga, María Calatayud, Almudena Vicente, Gonzalo García-de-Casasola, Ancor Sanz-García, Marta Araujo-Castro, Ignacio Ruz-Caracuel, Manel Puig-Domingo, Mónica Marazuela
Pituitary neuroendocrine tumors (PitNETs) account for approximately 15% of all intracranial neoplasms. Although they usually appear to be benign, some tumors display worse behavior, displaying rapid growth, invasion, refractoriness to treatment, and recurrence. Increasing evidence supports the role of primary cilia (PC) in regulating cancer development. Here, we showed that PC are significantly increased in PitNETs and are associated with increased tumor invasion and recurrence. Serial electron micrographs of PITNETs demonstrated different ciliation phenotypes (dot-like versus normal-like cilia) that represented PC at different stages of ciliogenesis...
March 18, 2024: Modern Pathology
https://read.qxmd.com/read/38505563/transcriptome-analysis-reveals-distinct-patterns-between-the-invasive-and-noninvasive-pituitary-neuroendocrine-tumors
#19
JOURNAL ARTICLE
Jelena Jotanovic, Abdellah Tebani, Neda Hekmati, Åsa Sivertsson, Cecilia Lindskog, Mathias Uhlèn, Olafur Gudjonsson, Erika Tsatsaris, Britt Edén Engström, Johan Wikström, Fredrik Pontén, Olivera Casar-Borota
Although most pituitary neuroendocrine tumors (PitNETs)/pituitary adenomas remain intrasellar, a significant proportion of tumors show parasellar invasive growth and 6% to 8% infiltrate the bone structures, thus affecting the prognosis. There is an unmet need to identify novel markers that can predict the parasellar growth of PitNETs. Furthermore, mechanisms that regulate bone invasiveness of PitNETs and factors related to tumor vascularization are largely unknown. We used genome-wide mRNA analysis in a cohort of 77 patients with PitNETs of different types to explore the differences in gene expression patterns between invasive and noninvasive tumors with respect to the parasellar growth and regarding the rare phenomenon of bone invasiveness...
March 12, 2024: Journal of the Endocrine Society
https://read.qxmd.com/read/38503992/excess-mortality-in-patients-with-non-functioning-pituitary-adenoma-a-systematic-review-and-meta-analysis
#20
REVIEW
F Bioletto, M Sibilla, V Gasco, E Ghigo, S Grottoli
BACKGROUND: Patients with non-functioning pituitary adenoma (NFPA) often present with a variety of clinical manifestations and comorbidities, mainly determined by the local mass effect of the tumor and by hypopituitarism. Whether this has an impact on overall mortality, however, is still unclear. METHODS: PubMed/Medline, EMBASE, and Cochrane Library databases were systematically searched until May 2023 for studies reporting data either about standardized mortality ratios (SMRs) or about predictors of mortality in patients with NFPA...
March 19, 2024: Journal of Endocrinological Investigation
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