Alexander H Yang, Brigit Sullivan, Christa S Zerbe, Suk See De Ravin, Andrew M Blakely, Martha M Quezado, Beatriz E Marciano, Jamie Marko, Alexander Ling, David E Kleiner, John I Gallin, Harry L Malech, Steven M Holland, Theo Heller
Chronic granulomatous disease (CGD) is a rare inborn error of immunity, resulting from a defect in nicotinamide adenine dinucleotide phosphate (NADPH) oxidation and decreased production of phagocyte reactive oxygen species. The main clinical manifestations are recurrent infections and chronic inflammatory disorders. Current approaches to management include antimicrobial prophylaxis and control of inflammatory complications. Hematopoietic stem cell transplantation (HSCT) or gene therapy can provide definitive treatment...
January 13, 2023: Journal of Allergy and Clinical Immunology in Practice