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Intestinal chronic dysmotility

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https://www.readbyqxmd.com/read/27683196/chronic-intestinal-pseudo-obstruction-in-children-and-adults-diagnosis-and-therapeutic-options
#1
G Di Nardo, C Di Lorenzo, A Lauro, V Stanghellini, N Thapar, T B Karunaratne, U Volta, R De Giorgio
BACKGROUND: Chronic intestinal pseudo-obstruction (CIPO) represents the most severe form of gastrointestinal dysmotility with debilitating and potentially lethal consequences. Symptoms can be non-specific, and result in this condition being diagnosed incorrectly or too late with consequences for morbidity and even mortality. PURPOSE: The present article aims to provide pediatric and adult gastroenterologists with an up to date review about clinical features, diagnosis and therapeutic options for CIPO...
September 29, 2016: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/27427419/a-novel-mutation-in-nucleoporin-35-causes-murine-degenerative-colonic-smooth-muscle-myopathy
#2
Ian A Parish, Lincon A Stamp, Ayla May D Lorenzo, Suzanne M Fowler, Yovina Sontani, Lisa A Miosge, Debbie R Howard, Christopher C Goodnow, Heather M Young, John B Furness
Chronic intestinal pseudo-obstruction (CIPO) is a rare but life-threatening disease characterized by severe intestinal dysmotility. Histopathologic studies in CIPO patients have identified several different mechanisms that appear to be involved in the dysmotility, including defects in neurons, smooth muscle, or interstitial cells of Cajal. Currently there are few mouse models of the various forms of CIPO. We generated a mouse with a point mutation in the RNA recognition motif of the Nup35 gene, which encodes a component of the nuclear pore complex...
September 2016: American Journal of Pathology
https://www.readbyqxmd.com/read/27273837/chronic-intestinal-pseudo-obstruction-in-a-child-harboring-a-founder-hirschsprung-ret-mutation
#3
Valentina Rossi, Manuela Mosconi, Paolo Nozza, Daniele Murgia, Girolamo Mattioli, Isabella Ceccherini, Alessio Pini Prato
Chronic intestinal pseudo obstruction (CIPO) is a rare clinical entity characterized by symptoms and signs of intestinal obstruction without either recognizable anatomical abnormalities or intestinal aganglionosis. A Chinese female infant presented to our institution with a clinical diagnosis of CIPO. Aganglionosis was ruled out by full thickness colonic and ileal biopsies and by rectal suction biopsies. Unexpectedly, direct sequencing and PCR amplification of RET proto-oncogene from peripheral blood extracted DNA identified a RET R114H mutation...
September 2016: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/27259308/inhibitory-effects-and-sympathetic-mechanisms-of-distension-in-the-distal-organs-on-small-bowel-motility-and-slow-waves-in-canine
#4
Jun Song, Jieyun Yin, Jiande D Z Chen
Rectal distension (RD) is known to induce intestinal dysmotility. Few studies were performed to compare effects of RD, colon distension (CD) and duodenal distension (DD) on small bowel motility. This study aimed to investigate effects and underlying mechanisms of distensions in these regions on intestinal motility and slow waves. Eight dogs chronically implanted with a duodenal fistula, a proximal colon fistula, and intestinal serosal electrodes were studied in six sessions: control, RD, CD, DD, RD + guanethidine, and CD + guanethidine...
December 2015: Cell Biochemistry and Biophysics
https://www.readbyqxmd.com/read/27222079/patients-with-ckd-have-abnormal-upper-gastro-intestinal-tract-digestive-function-a-study-of-uremic-enteropathy
#5
Claire J Grant, Laura E Harrison, Caroline L Hoad, Luca Marciani, Penny A Gowland, Christopher W McIntyre
INTRODUCTION: Chronic kidney disease (CKD) affects gastrointestinal function and results in numerous adaptive and maladaptive responses. Disruption of the colonic microbiome and its attendant consequences - the loss of gut barrier integrity and increased generation of uremic toxins - has become well-recognized. However, less attention has been paid to characterizing the mechanisms behind dysfunction of the upper gastrointestinal (GI) tract, largely owing to the difficulty of studying small bowel function in vivo...
May 25, 2016: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/26886038/-gastrointestinal-causes-of-weight-loss-clinical-presentation-diagnostic-workup-and-therapy
#6
REVIEW
Sophie Fromhold-Treu, Georg Lamprecht
This review describes the gasterointestinal entities, their pathophysiology, clinical presentation, diagnostic workup and therapy that typically involve weight loss as the major presenting symptom. The differentiation of malassimilation into maldigestion and malabsorption is clinically mostly not helpful. Instead primary malasssimilation can be distinguished from secondary due to another disease. Celiac disease, lambliasis, small bowel CD, CVIDS and Whipple's disease result in loss of absorptive surface. Chronic intestinal pseudobstruction leads to weight loss through dysmotility and postprandial pain...
February 2016: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/26818425/short-bowel-syndrome-and-intestinal-failure-in-crohn-s-disease
#7
Berkeley N Limketkai, Alyssa M Parian, Neha D Shah, Jean-Frédéric Colombel
Crohn's disease is a chronic and progressive inflammatory disorder of the gastrointestinal tract. Despite the availability of powerful immunosuppressants, many patients with Crohn's disease still require one or more intestinal resections throughout the course of their disease. Multiple resections and a progressive reduction in bowel length can lead to the development of short bowel syndrome, a form of intestinal failure that compromises fluid, electrolyte, and nutrient absorption. The pathophysiology of short bowel syndrome involves a reduction in intestinal surface area, alteration in the enteric hormonal feedback, dysmotility, and related comorbidities...
May 2016: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/26661570/comparative-quantitative-assessment-of-global-small-bowel-motility-using-magnetic-resonance-imaging-in-chronic-intestinal-pseudo-obstruction-and-healthy-controls
#8
A Menys, S Butt, A Emmanuel, A A Plumb, A Fikree, C Knowles, D Atkinson, N Zarate, S Halligan, S A Taylor
BACKGROUND: Chronic intestinal pseudo-obstruction (CIPO) is characterized by dilatation of the bowel lumen and abnormal motility. In this study, we aimed to quantify small bowel dysmotility in CIPO using a validated pan-intestinal motility assessment technique based on motion capture magnetic resonance imaging (MRI) compared to normal controls. In addition, we explored if motility responses of CIPO patients to neostigmine challenge differed from healthy volunteers. METHODS: Twenty healthy volunteers (mean age 28, range 22-48) and 11 CIPO patients (mean age 47, range 19-90) underwent MRI enterography to capture global small bowel motility...
March 2016: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/26488457/a-single-center-adult-chronic-intestinal-failure-cohort-analyzed-according-to-the-espen-endorsed-recommendations-definitions-and-classifications
#9
Christopher Filtenborg Brandt, Siri Tribler, Mark Hvistendahl, Michael Staun, Per Brøbech, Palle Bekker Jeppesen
BACKGROUND/AIMS: The objective of this study was to describe a clinically well-defined, single-center, intestinal failure (IF) cohort based on a template of definitions and classifications endorsed by the European Society for Clinical Nutrition and Metabolism (ESPEN). METHODS: A cross-sectional, retrospective, adult IF cohort, receiving parenteral support (PS), was extracted from the Copenhagen IF database at the tertiary IF center, Copenhagen University Hospital, Rigshospitalet, Denmark...
October 20, 2015: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/26387781/effect-of-neostigmine-on-gastroduodenal-motility-in-patients-with-suspected-gastrointestinal-motility-disorders
#10
G Parthasarathy, K Ravi, M Camilleri, C Andrews, L A Szarka, P A Low, A R Zinsmeister, A E Bharucha
BACKGROUND: Acetylcholinesterase inhibitors (ACIs), e.g., neostigmine, are known to increase upper and lower gastrointestinal (GI) motility and are used to treat acute colonic pseudoobstruction. However, their effects on gastroduodenal motility in humans are poorly understood. Our hypotheses were that, in patients with suspected GI motility disorders, neostigmine increases gastric and small intestinal motor activity, and these effects are greater in patients with cardiovagal neuropathy, reflecting denervation sensitivity...
December 2015: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/26252289/gad-antibodies-as-key-link-between-chronic-intestinal-pseudoobstruction-autonomic-neuropathy-and-limb-stiffness-in-a-nondiabetic-patient-a-care-compliant-case-report-and-review-of-the-literature
#11
REVIEW
Andrea Maier, Vera Mannartz, Hermann Wasmuth, Christian Trautwein, Ulf-Peter Neumann, Joachim Weis, Joachim Grosse, Matthias Fuest, Max-J Hilz, Joerg B Schulz, Christina Haubrich
Chronic intestinal pseudoobstruction (CIP) can be a severe burden and even a life-threatening disorder. Typically, several years of uncertainty are passing before diagnosis. We are reporting the case of a young woman with a decade of severe, progressive gastrointestinal dysmotility. Unusually, she had also developed an autonomic neuropathy, and a stiff limb syndrome.In addition to achalasia and CIP the young woman also developed neuropathic symptoms: orthostatic intolerance, urinary retention, a Horner syndrome, and lower limb stiffness...
August 2015: Medicine (Baltimore)
https://www.readbyqxmd.com/read/26239907/oxalate-nephropathy-in-systemic-sclerosis-case-series-and-review-of-the-literature
#12
REVIEW
Colin B Ligon, Laura K Hummers, Zsuzsanna H McMahan
OBJECTIVE: To increase awareness of oxalate nephropathy as a cause of acute kidney injury (AKI) among systemic sclerosis patients with small intestinal dysmotility and malabsorption, and to prompt consideration of dietary modification and early treatment of predisposing causes of oxalate nephropathy in this population. METHODS: Two cases of biopsy-proven oxalate nephropathy were identified among systemic sclerosis patients in the course of direct clinical care. Subsequently, a retrospective search of the Johns Hopkins Pathology databases identified a third patient with systemic sclerosis who developed oxalate nephropathy...
December 2015: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/26194403/the-role-of-mast-cells-in-functional-gi-disorders
#13
REVIEW
Mira M Wouters, Maria Vicario, Javier Santos
Functional gastrointestinal disorders (FGIDs) are characterized by chronic complaints arising from disorganized brain-gut interactions leading to dysmotility and hypersensitivity. The two most prevalent FGIDs, affecting up to 16-26% of worldwide population, are functional dyspepsia and irritable bowel syndrome. Their etiopathogenic mechanisms remain unclear, however, recent observations reveal low-grade mucosal inflammation and immune activation, in association with impaired epithelial barrier function and aberrant neuronal sensitivity...
January 2016: Gut
https://www.readbyqxmd.com/read/26064396/needleless-transcutaneous-electroacupuncture-improves-rectal-distension-induced-impairment-in-intestinal-motility-and-slow-waves-via-vagal-mechanisms-in-dogs
#14
Jun Song, Jieyun Yin, Jiande Chen
AIM: This study was designed to compare the effects and mechanisms of transcutaneous electroacupuncture (TEA) on rectal distention (RD)-induced intestinal dysmotility with EA. METHODS: six female dogs chronically implanted with a duodenal fistula, a proximal colon fistula and intestinal serosal electrodes were studied. EA and TEA were performed via needles and cutaneous electrodes placed at bilateral ST-36 (Zusanli) acupoints respectively; their effects on postprandial intestinal dysmotility (slow waves, contractions and transit) induced by RD, and autonomic functions were compared...
2015: International Journal of Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/25971881/early-investigational-therapeutics-for-gastrointestinal-motility-disorders-from-animal-studies-to-phase-ii-trials
#15
REVIEW
Nelson Valentin, Andres Acosta, Michael Camilleri
INTRODUCTION: The most common gastrointestinal disorders that include evidence of dysmotility include: gastroparesis, the lower functional gastrointestinal disorders associated with altered bowel function (such as chronic [functional] diarrhea, chronic idiopathic constipation) and opioid-induced constipation. These conditions, which are grouped as gastrointestinal motility and functional disorders, are characterized by abnormal motor, sensory or secretory functions that alter bowel function and result in a significant disease burden, since currently available treatments do not completely alleviate symptoms...
June 2015: Expert Opinion on Investigational Drugs
https://www.readbyqxmd.com/read/25944232/current-knowledge-on-regulation-and-impairment-of-motility-after-intestinal-transplantation
#16
REVIEW
Martin W von Websky, Joerg C Kalff, Nico Schäfer
PURPOSE OF REVIEW: Understanding the key mechanisms impacting on intestinal graft motility is paramount for successful intestinal transplantation. In this review, we will discuss causes of graft hypomotility and hypermotility, rooted in changes of the intrinsic nervous system, local inflammatory processes, adaptive immune responses, and more. RECENT FINDINGS: Recently, it has been shown that the gut microbiome closely interacts with the structural integrity and rejection processes in the small intestine...
June 2015: Current Opinion in Organ Transplantation
https://www.readbyqxmd.com/read/25926033/clinical-management-of-post-pyloric-enteral-feeding-in-children
#17
REVIEW
Teresa Capriati, Sabrina Cardile, Fabrizio Chiusolo, Filippo Torroni, Paolo Schingo, Domenica Elia, Antonella Diamanti
Post-pyloric feeding (PF) allows the administration of enteral nutrition beyond the pylorus, either into the duodenum or, ideally, into the jejunum. The main indications of PF are: upper gastrointestinal tract obstructions, pancreatic rest (e.g., acute pancreatitis), gastric dysmotility (e.g., critically ill patients and chronic intestinal pseudo-obstruction) or severe gastroesophageal reflux with risk of aspiration (e.g., neurological disability). Physiological and clinical evidence derives from adults, but can also be pertinent to children...
July 2015: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/25890715/acellular-bi-layer-silk-fibroin-scaffolds-support-functional-tissue-regeneration-in-a-rat-model-of-onlay-esophagoplasty
#18
Khalid Algarrahi, Debra Franck, Chiara E Ghezzi, Vivian Cristofaro, Xuehui Yang, Maryrose P Sullivan, Yeun Goo Chung, Saif Affas, Russell Jennings, David L Kaplan, Carlos R Estrada, Joshua R Mauney
Surgical management of long-gap esophageal defects with autologous gastrointestinal tissues is frequently associated with adverse complications including organ dysmotility, dysphagia, and donor site morbidity. In order to develop alternative graft options, bi-layer silk fibroin (SF) scaffolds were investigated for their potential to support functional tissue regeneration in a rodent model of esophageal repair. Onlay esophagoplasty was performed with SF matrices (N = 40) in adult rats for up to 2 m of implantation...
June 2015: Biomaterials
https://www.readbyqxmd.com/read/25592315/severe-gastrointestinal-dysmotility-developed-after-treatment-with-gonadotropin-releasing-hormone-analogs
#19
Lina Cordeddu, Monika Bergvall, Elin Sand, Bodil Roth, Evangelia Papadaki, Ling Li, Mauro D'Amato, Bodil Ohlsson
BACKGROUND: Sporadic cases of abdominal pain and dysmotility has been described after treatment with gonadotropin-releasing hormone (GnRH) analogs. The aim of the present study was to scrutinize for patients with severe gastrointestinal complaints after treatment with GnRH analogs, to describe the expression of antibodies against progonadoliberin-2, GnRH1, GnRH receptor (GnRHR), luteinizing hormone (LH), and LH receptor in serum in these patients, and to search for possible triggers and genetic factors behind the development of this dysmotility...
March 2015: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/25575569/mutations-in-rad21-disrupt-regulation-of-apob-in-patients-with-chronic-intestinal-pseudo-obstruction
#20
Elena Bonora, Francesca Bianco, Lina Cordeddu, Michael Bamshad, Ludmila Francescatto, Dustin Dowless, Vincenzo Stanghellini, Rosanna F Cogliandro, Greger Lindberg, Zeynel Mungan, Kivanc Cefle, Tayfun Ozcelik, Sukru Palanduz, Sukru Ozturk, Asuman Gedikbasi, Alessandra Gori, Tommaso Pippucci, Claudio Graziano, Umberto Volta, Giacomo Caio, Giovanni Barbara, Mauro D'Amato, Marco Seri, Nicholas Katsanis, Giovanni Romeo, Roberto De Giorgio
BACKGROUND & AIMS: Chronic intestinal pseudo-obstruction (CIPO) is characterized by severe intestinal dysmotility that mimics a mechanical subocclusion with no evidence of gut obstruction. We searched for genetic variants associated with CIPO to increase our understanding of its pathogenesis and to identify potential biomarkers. METHODS: We performed whole-exome sequencing of genomic DNA from patients with familial CIPO syndrome. Blood and lymphoblastoid cells were collected from patients and controls (individuals without CIPO); levels of messenger RNA (mRNA) and proteins were analyzed by quantitative reverse-transcription polymerase chain reaction, immunoblot, and mobility shift assays...
April 2015: Gastroenterology
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