keyword
https://read.qxmd.com/read/38656802/which-factors-influence-the-participation-in-statutory-skin-cancer-screenings-in-germany
#1
JOURNAL ARTICLE
Valerie Andrees, Sandra Wolf, Jan Liebers, Matthias Augustin, Gefion Girbig
BACKGROUND AND OBJECTIVES: Due to increasing skin cancer incidence, Germany implemented a statutory nationwide routine skin cancer screening (rSCS) in 2008. The present study aims (1) to analyze which patient factors are associated with the participation in rSCS in Germany and (2) to investigate reasons for nonparticipation. PATIENTS AND METHODS: Participants and nonparticipants of rSCS (≥ 35 years) were recruited in routine care in nine dermatological outpatient clinics...
April 24, 2024: Journal der Deutschen Dermatologischen Gesellschaft: JDDG
https://read.qxmd.com/read/38655134/a-bibliometric-analysis-of-cardiotoxicity-in-cancer-radiotherapy
#2
Mengting Che, Yuanqiong Duan, Rutie Yin
BACKGROUND: Radiotherapy, a primary treatment for malignant cancer, presents significant clinical challenges globally due to its associated adverse effects, especially with the increased survival rates of cancer patients. Radiation induced heart disease (RIHD) significantly impacts the long-term survival and quality of life of cancer survivors as one of the most devastating consequences. Quite a few studies have been conducted on preclinical and clinical trials of RIHD, showing promising success to some extent...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38654924/undiagnosed-rasopathies-in-infertile-men
#3
JOURNAL ARTICLE
Anna-Grete Juchnewitsch, Kristjan Pomm, Avirup Dutta, Erik Tamp, Anu Valkna, Kristiina Lillepea, Eisa Mahyari, Stanislav Tjagur, Galina Belova, Viljo Kübarsepp, Helen Castillo-Madeen, Antoni Riera-Escamilla, Lisanna Põlluaas, Liina Nagirnaja, Olev Poolamets, Vladimir Vihljajev, Mailis Sütt, Nassim Versbraegen, Sofia Papadimitriou, Robert I McLachlan, Keith A Jarvi, Peter N Schlegel, Sven Tennisberg, Paul Korrovits, Katinka Vigh-Conrad, Moira K O'Bryan, Kenneth I Aston, Tom Lenaerts, Donald F Conrad, Laura Kasak, Margus Punab, Maris Laan
RASopathies are syndromes caused by congenital defects in the Ras/mitogen-activated protein kinase (MAPK) pathway genes, with a population prevalence of 1 in 1,000. Patients are typically identified in childhood based on diverse characteristic features, including cryptorchidism (CR) in >50% of affected men. As CR predisposes to spermatogenic failure (SPGF; total sperm count per ejaculate 0-39 million), we hypothesized that men seeking infertility management include cases with undiagnosed RASopathies. Likely pathogenic or pathogenic (LP/P) variants in 22 RASopathy-linked genes were screened in 521 idiopathic SPGF patients (including 155 CR cases) and 323 normozoospermic controls using exome sequencing...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38654470/role-of-parental-smoking-and-environmental-tobacco-smoke-exposure-in-childhood-cancer-a-study-using-hair-cotinine-analysis-and-questionnaires
#4
JOURNAL ARTICLE
Adil Guzel, Nurdan Tacyildiz, Filiz Bakar-Ates, Derya Ozyoruk, Aybuke Celik, Handan Dincaslan, Emel Cabi Unal
OBJECTIVES: In the etiology of childhood cancers, many genetic and environmental factors play a role. One of these factors could be cigarette smoking, and the main source of tobacco smoke exposure of children is parental smoking. However, establishing a causal relationship between parental smoking and childhood cancers has proven challenging due to difficulties in accurately detecting tobacco smoke exposure METHODS: To address this issue, we used hair cotinine analysis and a questionnaire to get information about tobacco smoke exposures of pediatric cancer patients and healthy children...
April 23, 2024: Pediatric Blood & Cancer
https://read.qxmd.com/read/38652878/trans-ancestral-genetic-risk-factors-for-treatment-related-type-2-diabetes-mellitus-in-survivors-of-childhood-cancer
#5
JOURNAL ARTICLE
Cindy Im, Achal Neupane, Jessica L Baedke, Brian Lenny, Angela Delaney, Stephanie B Dixon, Eric J Chow, Sogol Mostoufi-Moab, Tianzhong Yang, Melissa A Richard, M Monica Gramatges, Philip J Lupo, Noha Sharafeldin, Smita Bhatia, Gregory T Armstrong, Melissa M Hudson, Kirsten K Ness, Leslie L Robison, Yutaka Yasui, Carmen L Wilson, Yadav Sapkota
PURPOSE: Type 2 diabetes mellitus (T2D) is a prevalent long-term complication of treatment in survivors of childhood cancer, with marked racial/ethnic differences in burden. In this study, we investigated trans-ancestral genetic risks for treatment-related T2D. PATIENTS AND METHODS: Leveraging whole-genome sequencing data from the St Jude Lifetime Cohort (N = 3,676, 304 clinically ascertained cases), we conducted ancestry-specific genome-wide association studies among survivors of African and European genetic ancestry (AFR and EUR, respectively) followed by trans-ancestry meta-analysis...
April 23, 2024: Journal of Clinical Oncology
https://read.qxmd.com/read/38652503/associations-of-early-life-and-adult-anthropometric-measures-with-the-expression-of-stem-cell-markers-cd44-cd24-and-aldh1a1-in-women-with-benign-breast-biopsies
#6
JOURNAL ARTICLE
Hannah Oh, Lusine Yaghjyan, Yujing J Heng, Bernard Rosner, Matt B Mahoney, Divya Murthy, Gabrielle M Baker, Rulla M Tamimi
BACKGROUND: According to the stem cell hypothesis, breast carcinogenesis may be related to the breast stem cell pool size. However, little is known about associations of breast cancer risk factors, such as anthropometric measures, with the expression of stem cell markers in non-cancerous breast tissue. METHODS: The analysis included 414 women with biopsy-confirmed benign breast disease (BBD) in the Nurses' Health Study (NHS) and NHSII. Birthweight, weight at age 18, current weight, and current height were reported via self-administered questionnaire...
April 23, 2024: Cancer Epidemiology, Biomarkers & Prevention
https://read.qxmd.com/read/38652494/exercise-and-quality-diet-after-leukemia-equal-a-randomized-weight-loss-trial-among-adult-survivors-of-childhood-leukemia-in-the-childhood-cancer-survivor-study
#7
JOURNAL ARTICLE
Danielle Novetsky Friedman, Joanne F Chou, Jeanne M Clark, Chaya S Moskowitz, Jennifer S Ford, Gregory T Armstrong, Nidha Z Mubdi, Aaron McDonald, Paul C Nathan, Charles A Sklar, Lakshmi V Ramanathan, Leslie L Robison, Kevin C Oeffinger, Emily S Tonorezos
BACKGROUND: Obesity is prevalent in childhood cancer survivors and interacts with cancer treatments to potentiate risk for cardiovascular (CV) death. We tested a remote weight-loss intervention that was effective among adults with CV risk factors in a cohort of adult survivors of childhood acute lymphoblastic leukemia (ALL) with overweight/obesity. METHODS: In this phase 3 efficacy trial, survivors of ALL enrolled in the Childhood Cancer Survivor Study with body mass index (BMI)≥25 kg/m2 were randomized to a remotely-delivered weight-loss intervention versus self-directed weight loss, stratified by history of cranial radiotherapy (CRT)...
April 23, 2024: Cancer Epidemiology, Biomarkers & Prevention
https://read.qxmd.com/read/38651186/flow-cytometric-minimal-residual-disease-measurement-accounting-for-cytogenetics-in-children-with-non-high-risk-acute-lymphoblastic-leukemia-treated-according-to-the-all-mb-2008-protocol
#8
JOURNAL ARTICLE
Alexander Popov, Guenter Henze, Grigory Tsaur, Oleg Budanov, Julia Roumiantseva, Mikhail Belevtsev, Tatiana Verzhbitskaya, Liudmila Movchan, Svetlana Lagoyko, Liudmila Zharikova, Yulia Olshanskaya, Tatiana Riger, Alena Valochnik, Natalia Miakova, Dmitry Litvinov, Olga Khlebnikova, Olga Streneva, Elena Stolyarova, Natalia Ponomareva, Galina Novichkova, Olga Aleinikova, Larisa Fechina, Alexander Karachunskiy
BACKGROUND: Quantitative measurement of minimal residual disease (MRD) is the "gold standard" for estimating the response to therapy in childhood B-cell precursor acute lymphoblastic leukemia (BCP-ALL). Nevertheless, the speed of the MRD response differs for different cytogenetic subgroups. Here we present results of MRD measurement in children with BCP-ALL, in terms of genetic subgroups with relation to clinically defined risk groups. METHODS: A total of 485 children with non-high-risk BCP-ALL with available cytogenetic data and MRD studied at the end-of-induction (EOI) by multicolor flow cytometry (MFC) were included...
April 2024: Cancer Medicine
https://read.qxmd.com/read/38650581/incidence-and-prevalence-of-musculoskeletal-health-conditions-in-survivors-of-childhood-and-adolescent-cancers-a-report-from-the-swiss-childhood-cancer-survivor-study
#9
JOURNAL ARTICLE
Salome Christen, Katharina Roser, Luzius Mader, Maria Otth, Katrin Scheinemann, Grit Sommer, Claudia Kuehni, Gisela Michel
PURPOSE: Childhood cancer and its treatment can cause damage to the musculoskeletal system. We aimed to determine the incidence and prevalence of musculoskeletal health conditions (MSHC) in survivors, and to investigate differences by cancer-related characteristics. METHODS: We used data from the Childhood Cancer Registry and the Swiss Childhood Cancer Survivor Study, including survivors (≥5 years since diagnosis; diagnosed 1976-2015 at <20 years of age) aged ≥15 years at study...
April 2024: Cancer Medicine
https://read.qxmd.com/read/38649363/mettl14-promotes-neuroblastoma-formation-by-inhibiting-ywhah-via-an-m6a-ythdf1-dependent-mechanism
#10
JOURNAL ARTICLE
Jianwei Wang, Hongli Yin, Gen Li, Di Wu, Yunyun Xu, Yanling Chen, Xiaodong Wang, Yujiao Xing, Ting Zhang, Danhong Fei, Pengcheng Yang, Fang Fang, Yanfang Tao, Xiaolu Li, Juanjuan Yu, Yang Yang, Zhiheng Li, Lei Shi, Zimu Zhang, Jian Pan
Neuroblastoma (NB) is a common childhood tumor with a high incidence worldwide. The regulatory role of RNA N6-methyladenosine (m6A) in gene expression has attracted significant attention, and the impact of methyltransferase-like 14 (METTL14) on tumor progression has been extensively studied in various types of cancer. However, the specific influence of METTL14 on NB remains unexplored. Using data from the Target database, our study revealed significant upregulation of METTL14 expression in high-risk NB patients, with strong correlation with poor prognosis...
April 22, 2024: Cell Death Discovery
https://read.qxmd.com/read/38648182/translating-a-motivational-interviewing-intervention-for-childhood-cancer-survivors-into-an-ehealth-tool-a-user-centered-design-process
#11
JOURNAL ARTICLE
Sienna Ruiz, Nicole Ackermann, Julia Maki, April Idalski Carcone, Melissa M Hudson, Matthew J Ehrhardt, Danielle Cloakey, Danielle DuChateau, Stanford A Griffith, Allison Johnson, Aaron Phillips, Erika A Waters
Childhood cancer survivors have a higher risk of developing cardiomyopathy than members of the general population. Screening echocardiograms can facilitate early detection and treatment of cardiomyopathy. Furthermore, motivational interviewing can increase uptake of cardiac screening. However, such approaches are time- and resource-intensive, which limits their reach to the survivors who need them. We describe how we utilized a user-centered design process to translate an in-person motivational interviewing intervention into an eHealth tool to improve cardiac screening among childhood cancer survivors...
April 22, 2024: Translational Behavioral Medicine
https://read.qxmd.com/read/38647670/reasons-why-the-idea-that-radiation-exposures-induce-cancer-needs-to-be-revisited
#12
JOURNAL ARTICLE
Nori Nakamura
PURPOSE: It has long been thought that the carcinogenic effect of radiation resulted from the induction of oncogenic mutations which then led to an increase in the proportion of cancer-bearing individuals. However, even as early as the 1960s, there were indications that the carcinogenic effect of radiation might result from the induction of an earlier onset of cancer. Recently, the former notion was challenged by its inability to explain time-dependent decline of the relative risk following an exposure to radiation, and a parallel shift of mouse survival curves toward younger ages following an exposure to radiation...
April 22, 2024: International Journal of Radiation Biology
https://read.qxmd.com/read/38645102/rurality-cardiovascular-risk-factors-and-early-cardiovascular-disease-among-childhood-adolescent-and-young-adult-cancer-survivors
#13
David H Noyd, Anna Bailey, Amanda Janitz, Talayeh Razzaghi, Sharon Bouvette, William Beasley, Ashley Baker, Sixia Chen, David Bard
Cardiovascular risk factors (CVRFs) later in life potentiate risk for late cardiovascular disease (CVD) from cardiotoxic treatment among survivors. This study evaluated the association of baseline CVRFs and CVD in the early survivorship period. Methods This analysis included patients ages 0-29 at initial diagnosis and reported in the institutional cancer registry between 2010 and 2017 (n = 1228). Patients who died within five years (n = 168), those not seen in the oncology clinic (n = 312), and those with CVD within one year of diagnosis (n = 17) were excluded...
April 1, 2024: Research Square
https://read.qxmd.com/read/38644606/late-onset-lymphopenia-during-radiation-is-associated-with-an-increased-risk-of-tumor-recurrence-in-newly-diagnosed-pediatric-medulloblastoma
#14
JOURNAL ARTICLE
Holly B Lindsay, Michael E Scheurer, Anthony K Allam, Bryony J Lucas, Susan L McGovern, Murali Chintagumpala, Arnold C Paulino
BACKGROUND: Recent data found a correlation between lymphopenia occurring early during craniospinal radiation therapy (RT) and risk of disease recurrence in newly diagnosed childhood medulloblastoma. However, the population included patients who received chemotherapy prior to or during RT. Here, we investigate the effect of lymphopenia during RT in patients with newly diagnosed pediatric medulloblastoma who were chemotherapy-naïve. PROCEDURE: We analyzed 79 patients with newly diagnosed medulloblastoma (ages 2-21 years) treated between 1997 and 2013 with craniospinal RT...
April 21, 2024: Pediatric Blood & Cancer
https://read.qxmd.com/read/38644601/quality-of-life-in-children-and-adolescents-after-treatment-for-acute-lymphoblastic-leukemia-according-to-the-nopho-all2008-protocol
#15
JOURNAL ARTICLE
Nina Mogensen, Ulrika Kreicbergs, Birgitte Klug Albertsen, Päivi M Lähteenmäki, Mats Heyman, Arja Harila
BACKGROUND: The improved outcome of childhood acute lymphoblastic leukemia (ALL) over the last decades has increased the importance of assessing late effects and health-related quality of life (HRQoL), particularly when evaluating and comparing outcomes in clinical trials. This study aimed to assess HRQoL in children treated for ALL according to the NOPHO ALL2008 protocol. PROCEDURE: Children, aged 1 to less than 18 years at diagnosis, alive in first remission, and their parents, were asked to complete PedsQL 4...
April 21, 2024: Pediatric Blood & Cancer
https://read.qxmd.com/read/38644484/impact-of-the-covid-19-pandemic-on-utilization-and-cost-for-care-of-pediatric-and-young-adult-all
#16
JOURNAL ARTICLE
Alex Hoover, Dave Watson, Paige Reimche, Lynn Tanner, Laura Gilchrist, Mike Finch, Yoav H Messinger, Lucie M Turcotte
OBJECTIVE: Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy and among the most common malignancies in young adults and requires a unique pattern of healthcare utilization including an acute/emergent presentation and an intensive initial 8 months of therapy followed by two years of outpatient treatment. The COVID-19 pandemic caused massive global disruptions in healthcare use and delivery. This report aims to examine the effects of the COVID-19 pandemic on the presentation, diagnosis and continued management of childhood and young adult ALL in regard to utilization and cost of care among commercially insured individuals in the United States...
April 22, 2024: BMC Research Notes
https://read.qxmd.com/read/38641417/the-complexities-of-pm2-5-greenspace-and-childhood-cancer
#17
EDITORIAL
Rena R Jones
No abstract text is available yet for this article.
April 19, 2024: Journal of the National Cancer Institute
https://read.qxmd.com/read/38639926/association-of-ideal-cardiovascular-health-in-youth-with-cancer-risk-in-adulthood-cardiovascular-risk-in-young-finns-study
#18
JOURNAL ARTICLE
Jussi Niemelä, Joel Nuotio, Tomi T Laitinen, Mika Kähönen, Nina Hutri, Terho Lehtimäki, Eero Jokinen, Päivi Tossavainen, Tomi P Laitinen, Olli J Heinonen, Terence Dwyer, Katja Pahkala, Suvi P Rovio, Jorma Viikari, Olli Raitakari, Markus Juonala
BACKGROUND: Lifestyle factors may affect cancer risk. This study aimed to identify whether American Heart Association (AHA) Ideal Cardiovascular Health (ICH) score and its individual variables in youth associate with subsequent cancer incidence. METHODS: Study comprised of participants of the Cardiovascular Risk in Young Finns Study free of cancer at analysis baseline in 1986 (n=1873). Baseline age was 12-24 years and the follow-up occurred between 1986-2018. RESULTS: Among 1873 participants (mean age 17...
April 19, 2024: Cancer Epidemiology, Biomarkers & Prevention
https://read.qxmd.com/read/38638849/oncolytic-virotherapy-stimulates-anti%C3%A2-tumor-immune-response-and-demonstrates-activity-in-advanced-sarcoma-report-of-two-cases
#19
Yeting Qiu, Aijun Qin, Ronghua Zhao, Jun Ding, William Wei-Guo Jia, Manu Singh, Yanal Murad, Qian Tan, Ganessan Kichenadasse
Sarcoma is derived from mesenchymal neoplasms and has numerous subtypes, accounting for 1% of all adult malignancies and 15% of childhood malignancies. The prognosis of metastatic or recurrent sarcoma remains poor. The current study presents two cases of sarcoma enrolled in a phase I dose escalation trial for solid tumor, who had previously failed all standard therapies. These patients were treated with VG161, an immune-stimulating herpes simplex virus type 1 oncolytic virus with payloads of IL-12, IL-15 and IL-15 receptor α unit, and a programmed cell death 1 (PD-1)/PD-1 ligand 1 blocking peptide...
June 2024: Oncology Letters
https://read.qxmd.com/read/38637875/pleuroparenchymal-fibroelastosis-as-a-late-complication-of-childhood-cancer-therapy-a-case-series
#20
JOURNAL ARTICLE
Priya H Marathe, Valeria Santibanez, Paul A Meyers, Maria L Padilla, Danielle N Friedman
Pleuroparenchymal fibroelastosis (PPFE) is a rare interstitial pneumonia with distinct clinicopathologic features. It has been associated with exposure to hematopoietic stem cell transplantation (HSCT) and classical alkylating agents. Here, we highlight PPFE as a late complication of childhood cancer therapy by describing the cases of four survivors of childhood cancer with a diagnosis of treatment-related PPFE. All patients received high-dose alkylating agents. PPFE should be considered in the differential diagnosis of restrictive lung disease in patients with history of exposure to alkylating agents or HSCT...
April 18, 2024: Pediatric Blood & Cancer
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