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https://www.readbyqxmd.com/read/29241176/surgery-of-intracranial-gliomas-in-children
#1
James A Balogun, James T Rutka
Gliomas are the most common type of brain cancer in the pediatric patients, constituting about 50% of all childhood intracranial tumors. This is a highly heterogeneous group, varying from the benign WHO histopathological grades I and II to malignant WHO grades III and IV. The histology and location are significant prognostic factors, which influence the decision for surgical intervention, as well as the extent of possible tumor removal. In low-grade gliomas, surgery remains the initial option and should be directed at gross total resection in favorable locations, such as the cerebral hemispheres and the cerebellum...
2018: Progress in Neurological Surgery
https://www.readbyqxmd.com/read/29240334/do-in-vitro-fertilization-treatments-result-in-healthy-babies
#2
Noora Kaartinen, Helena Tinkanen
In Finland, the proportion of children born as a result of in vitro fertilization treatments is annually approximately 3.3%, and the percentage proportion of the population is growing. Their general somatic health status and cognitive development do not differ from spontaneously fertilized children. In vitro fertilization treatments are, however, associated with a slightly elevated risk of preterm delivery, low birth weight and structural abnormalities. The risk of childhood cancer does not appear to be increased in IVF children...
2017: Duodecim; Lääketieteellinen Aikakauskirja
https://www.readbyqxmd.com/read/29240025/hypovitamininosis-d-in-childhood-cancer-survivors-importance-of-vitamin-d-supplementation-and-measurement-over-different-points-of-time
#3
Ashraf Fouda, Shaimaa Kandil, Khadijah Boujettif, Najwa Fayea
This observational retrospective cross-sectional and case-controlled study measures levels of 25-hydroxy-vitamin D (25-OH-VD) in pediatric cancer survivors at different intervals and assesses the effect of 2 supplementation regimens over a period of 12 months. Sixty-eight patients were included in this quasi-experimental study, of which 32 were boys and 36 were girls. A control group of 30 healthy children were included. It was found that initial 25-OH-VD levels were insufficient (<30 ng/mL) in 61 patients (89...
December 12, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29238226/maternal-diabetes-and-incidence-of-childhood-cancer-a-nationwide-cohort-study-and-exploratory-genetic-analysis
#4
Anna Deleskog, Marcel den Hoed, Giorgio Tettamanti, Sofia Carlsson, Rickard Ljung, Maria Feychting, Hannah L Brooke
Background: The etiology of childhood cancer is not well understood, but may be linked to prenatal and perinatal factors, such as maternal diabetes. However, this association has not been examined in depth. We aimed to determine if maternal diabetes is associated with risk of childhood brain tumor (CBT), leukemia (all types combined and acute lymphoblastic leukemia [ALL] separately), and lymphoma. Methods: All children born in Sweden between 1973 and 2014 (n=4,239,965) were followed from birth until first cancer diagnosis, age 15 years, or December 31, 2015...
2017: Clinical Epidemiology
https://www.readbyqxmd.com/read/29237091/epidermodysplasia-verruciformis-in-an-adult-patient-with-a-germline-itk-mutation-and-lymphoma-the-case-of-inherited-versus-acquired
#5
S Fouéré, F Aubin, H Péré, L Galicier, T Gheit, M Tommasino, C Ram Wolff, D Boutboul, M Bagot
Epidermodysplasia verruciformis (EV) is characterized by a clinically distinctive pattern of beta-HPV induced flat warts that may evolve into epithelial skin cancers. The current understanding is that EV encompasses two etiological situations: Classic, inherited type EV (IEV), beginning in childhood or adolescence, due to Trans Membrane Channel (TMC) - 6 and 7 (EVER-1 and 2) gene mutations 75% of patients, or to alterations resulting in T-Cell immune deficiencies (IDs) on Ras Homolog Family Member H (RHOH), Coronin 1A (CORO 1A), Macrophage Stimulating factor 1 (MST-1), or interleukin 7 (IL7) genes...
December 13, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29234490/geminin-deficiency-enhances-survival-in-a-murine-medulloblastoma-model-by-inducing-apoptosis-of-preneoplastic-granule-neuron-precursors
#6
Savita Sankar, Ethan Patterson, Emily M Lewis, Laura E Waller, Caili Tong, Joshua Dearborn, David Wozniak, Joshua B Rubin, Kristen L Kroll
Medulloblastoma is the most common malignant brain cancer of childhood. Further understanding of tumorigenic mechanisms may define new therapeutic targets. Geminin maintains genome fidelity by controlling re-initiation of DNA replication within a cell cycle. In some contexts, Geminin inhibition induces cancer-selective cell cycle arrest and apoptosis and/or sensitizes cancer cells to Topoisomerase IIα inhibitors such as etoposide, which is used in combination chemotherapies for medulloblastoma. However, Geminin's potential role in medulloblastoma tumorigenesis remained undefined...
September 2017: Genes & Cancer
https://www.readbyqxmd.com/read/29231963/body-composition-in-long-term-survivors-of-acute-lymphoblastic-leukemia-diagnosed-in-childhood-and-adolescence-a-focus-on-sarcopenic-obesity
#7
Christopher J C Marriott, Lesley F Beaumont, Troy H Farncombe, Amy N Cranston, Uma H Athale, Valerie N Yakemchuk, Colin E Webber, Ronald D Barr
BACKGROUND: The late effects of treatment for acute lymphoblastic leukemia (ALL) include disordered body composition, especially obesity. Less attention has been focused on the loss of skeletal muscle mass (SMM) and the combined morbidity of sarcopenic obesity. METHODS: A cross-sectional study of body composition was undertaken via dual-energy x-ray absorptiometry in 75 long-term survivors of ALL (more than 10 years after the diagnosis). Measures were obtained of the fat mass (FM), fat-free mass (equivalent to the lean body mass [LBM]), and whole-body bone mineral content...
December 12, 2017: Cancer
https://www.readbyqxmd.com/read/29230928/audiological-monitoring-in-swiss-childhood-cancer-patients
#8
Annette Weiss, Rahel Kuonen, Hanna Brockmeier, Michael Grotzer, Claudia Candreia, Raphael Maire, Pascal Senn, Christof Stieger, Jochen Rosenfeld, Dorothe Veraguth, Martin Kompis, Katrin Scheinemann, Claudia E Kuehni
BACKGROUND: Full audiological monitoring is the best strategy to detect hearing loss early and to provide timely intervention in the absence of a clinical method of otoprotection. Full monitoring requires audiological evaluation before, and then during and after ototoxic cancer treatment. In a worldwide context of monitoring protocols that vary substantially, we analyzed the audiological monitoring of childhood cancer patients over the last decade across treatment centers in Switzerland...
December 12, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29230080/cancer-victim-identity-for-individuals-with-histories-of-cancer-and-childhood-sexual-abuse
#9
Glynnis A McDonnell, Madalina Sucala, Rachel E Goldsmith, Guy H Montgomery, Julie B Schnur
Identifying as a 'cancer victim' has been linked to adverse psychosocial sequelae in individuals who have been diagnosed with cancer. Being a childhood sexual abuse (CSA) survivor may predispose individuals towards a "victim" identity in general. The aim of this study was to determine the prevalence of identifying as a 'cancer victim' among CSA survivors who were diagnosed with cancer as adults, and to explore psychological factors associated with identification as a cancer victim. 105 adults reporting both a history of CSA and of having been diagnosed with cancer as an adult were recruited through Amazon Mechanical Turk...
December 2017: Journal of Rational-emotive and Cognitive-behavior Therapy: RET
https://www.readbyqxmd.com/read/29229546/changes-in-cognition-and-dendritic-complexity-following-intrathecal-methotrexate-and-cytarabine-treatment-in-a-juvenile-murine-model
#10
Tyler C Alexander, Christy M Simecka, Frederico Kiffer, Thomas Groves, Julie Anderson, Hannah Carr, Jing Wang, Gwendolyn Carter, Antiño R Allen
Acute lymphoblastic leukemia (ALL) is the most prevalent childhood cancer and accounts for 26.8% of cancer diagnoses among children, worldwide-approximately 3,000 children each year. While advancements in treating ALL have led to a remission rate of more than 90%, many survivors experience adverse neurocognitive and/or neurobehavioral effects as a result of intrathecal chemotherapy. Methotrexate (MTX) is commonly administered with cytosine arabinoside (AraC, cytarabine) during intrathecal chemotherapy for ALL...
December 8, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/29229046/unemployment-following-childhood-cancer
#11
Luzius Mader, Gisela Michel, Katharina Roser
BACKGROUND: Childhood cancer survivors are at risk of physical and mental long-term sequelae that may interfere with their employment situation in adulthood. We updated a systematic review from 2006 and assessed unemployment in adult childhood cancer survivors compared to the general population, and its predictors. METHODS: Systematic literature searches for articles published between February 2006 and August 2016 were performed in CINAHL, EMBASE, PubMed, PsycINFO, and SocINDEX...
November 24, 2017: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/29228658/dna-methylation-landscape-of-hepatoblastomas-reveals-arrest-at-early-stages-of-liver-differentiation-and-cancer-related-alterations
#12
Mariana Maschietto, Tatiane Cristina Rodrigues, André Yoshiaki Kashiwabara, Érica Sara Souza de Araujo, Talita Ferreira Marques Aguiar, Cecilia Maria Lima da Costa, Isabela Werneck da Cunha, Luciana Dos Reis Vasques, Monica Cypriano, Helena Brentani, Silvia Regina Caminada de Toledo, Peter Lees Pearson, Dirce Maria Carraro, Carla Rosenberg, Ana C V Krepischi
Hepatoblastomas are uncommon embryonal liver tumors accounting for approximately 80% of childhood hepatic cancer. We hypothesized that epigenetic changes, including DNA methylation, could be relevant to hepatoblastoma onset. The methylomes of eight matched hepatoblastomas and non-tumoral liver tissues were characterized, and data were validated in an independent group (11 hepatoblastomas). In comparison to differentiated livers, hepatoblastomas exhibited a widespread and non-stochastic pattern of global low-level hypomethylation...
November 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29228199/new-neoplasm-during-gh-replacement-in-adults-with-pituitary-deficiency-following-malignancy-a-kims-analysis
#13
Katarzyna Krzyzanowska-Mittermayer, Anders F Mattsson, Dominique Maiter, Ulla Feldt-Rasmussen, Cecilia Camacho-Hübner, Anton Luger, Roger Abs
Context: Data on the association between growth hormone (GH) replacement in patients with GH deficiency (GHD) after malignancies and new neoplasms show conflicting results. Objective: To clarify the incidence of new malignant neoplasm in childhood (CO) and adult-onset (AO) adult cancer survivors (CS). Design: Retrospective comparison of CO-CS and AO-CS with CO idiopathic GHD (IGHD) and AO non-functioning pituitary adenoma patients (NFPA) and with the general population (standardized incidence ratio, SIR)...
December 7, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29225605/the-state-of-cellular-adoptive-immunotherapy-for-neuroblastoma-and-other-pediatric-solid-tumors
#14
Thanh-Phuong Le, To-Ha Thai
Research on adult cancer immunotherapy is proceeding at a rapid pace resulting in an impressive success rate exemplified by a few high profile cases. However, this momentum is not readily extended to pediatric immunotherapy, and it is not for lack of trying. Though reasons for the slower advance are not apparent, some issues can be raised. Pediatric cancer patients represent a distinct demographic group whose immune system is inherently different from that of mature adults. Treating pediatric patients with immunotherapy designed for adults may not yield objective clinical responses...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29222704/healthcare-system-barriers-to-long-term-follow-up-for-adult-survivors-of-childhood-cancer-in-british-columbia-canada-a-qualitative-study
#15
A Fuchsia Howard, Arminee Kazanjian, Sheila Pritchard, Rob Olson, Haroon Hasan, Kelly Newton, Karen Goddard
PURPOSE: Risk-stratified life-long follow-up care is recommended for adult childhood cancer survivors (CCS) to ensure appropriate prevention, screening, and management of late effects. The identification of barriers to long-term follow-up (LTFU), particularly in varying healthcare service contexts, is essential to develop and refine services that are responsive to survivor needs. We aimed to explore CCS and healthcare professionals (HCP) perspectives of healthcare system factors that function as barriers to LTFU in British Columbia, Canada...
December 8, 2017: Journal of Cancer Survivorship: Research and Practice
https://www.readbyqxmd.com/read/29221705/female-fertility-preservation-in-the-pediatric-and-adolescent-cancer-patient-population
#16
REVIEW
Gabriela N Algarroba, Joseph S Sanfilippo, Hanna Valli-Pulaski
The 5-year survival rate for childhood cancer is over 80%, thereby increasing the number of young women facing infertility in the future because of the gonadotoxic effects of chemotherapy and radiation. The gonadotoxic effects of childhood cancer treatment vary by the radiation regimen and the chemotherapeutic drugs utilized. Although the American Society of Clinical Oncology guidelines recommend fertility preservation for all patients, there are several barriers and ethical considerations to fertility preservation in the pediatric and adolescent female population...
October 26, 2017: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/29221117/inhibition-of-chemerin-cmklr1-axis-in-neuroblastoma-cells-reduces-clonogenicity-and-cell-viability-in-vitro-and-impairs-tumor-growth-in-vivo
#17
Conny Tümmler, Igor Snapkov, Malin Wickström, Ugo Moens, Linda Ljungblad, Lotta Helena Maria Elfman, Jan-Olof Winberg, Per Kogner, John Inge Johnsen, Baldur Sveinbjørnsson
Pro-inflammatory cells, cytokines, and chemokines are essential in promoting a tumor supporting microenvironment. Chemerin is a chemotactic protein and a natural ligand for the receptors CMKLR1, GPR1, and CCRL2. The chemerin/CMKLR1 axis is involved in immunity and inflammation, and it has also been implicated in obesity and cancer. In neuroblastoma, a childhood tumor of the peripheral nervous system we identified correlations between high CMKLR1 and GPR1 expression and reduced overall survival probability. CMKLR1, GPR1, and chemerin RNA and protein were detected in neuroblastoma cell lines and neuroblastoma primary tumor tissue...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29220543/skin-cancer-prevention-campaign-in-childhood-survey-based-on-3-676-children-in-brazil
#18
Paulo Ricardo Criado, Jorge Ocampo-Garza, Anne Lise Dias, Walter Belda Junior, Nilton Di Chiachio, Aparecida Machado de Moraes, Meire Brasil Parada, Fátima de Oliveira Rabay, Octavio Moraes Junior, Renato Sau Rios, Cristiana Silveira da Silva, Francisco C S Ferreira, Samuel Henrique Mandeulbaum, Cidia Vasconcellos
BACKGROUND AND OBJECTIVES: Primary skin cancer prevention campaigns are essential and more effective among children, not only because of the importance of sun exposure effects during this period, but also because at this age is when individuals are developing behaviors. The Brazilian Society of Dermatology - Regional State of Sao Paulo developed and conducted, the program named "The Sun, Friend of Childhood", a school health education and disease prevention project for children and parents...
December 8, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29212418/clinical-characteristics-and-outcome-of-childhood-acute-promyelocitic-leukemia-apl-in-saudi-arabia-a-multicenter-saphos-leukemia-group-study
#19
Wasil Jastaniah, Abdulrahman Alsultan, Saad Al Daama, Walid Ballourah, Mohamed Bayoumy, Faisal Al-Anzi, Omar Al Shareef, Mohammed Burhan Abrar, Reem Al Sudairy, Ibrahim Al Ghemlas
BACKGROUND: Acute promyelocytic leukemia (APL) is a rare form of acute myelogenous leukemia (AML). Survival rates exceed 80% in developed countries. Successful treatments rely on all-trans retinoic acid with anthracycline-based chemotherapy. Availability of modern care and public knowledge play important roles in pediatric APL survival. METHOD: A cytogenetic diagnosis of APL was confirmed in 30 (14.5%) out of 207 children consecutively diagnosed with de novo AML between January 2005 and December 2012 at nine cancer care centers in Saudi Arabia...
December 7, 2017: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/29212227/shift-in-energy-metabolism-caused-by-glucocorticoids-enhances-the-effect-of-cytotoxic-anti-cancer-drugs-against-acute-lymphoblastic-leukemia-cells
#20
Shigeki Aoki, Michie Morita, Takuya Hirao, Masashi Yamaguchi, Reika Shiratori, Megumi Kikuya, Hiroji Chibana, Kousei Ito
Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy. Treatments include glucocorticoids (GCs) such as dexamethasone (Dex) and prednisolone, which may be of value when used alongside cytotoxic anti-cancer drugs. To predict therapeutic efficacy of GCs, their activity against ALL cells is usually examined prior to chemotherapy; however, few studies have examined their effects when used in combination with other drugs. The paradox is that cytotoxic anti-cancer drugs that are effective against proliferating cancer cells show synergistic effects when used with GCs that prevent cell proliferation...
November 7, 2017: Oncotarget
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