keyword
MENU ▼
Read by QxMD icon Read
search

Key

keyword
https://www.readbyqxmd.com/read/28734243/caveolin-1-related-autophagy-initiated-by-aldosterone-induced-oxidation-promotes-liver-sinusoidal-endothelial-cells-defenestration
#1
Xiaoying Luo, Dan Wang, Xuan Luo, Xintao Zhu, Guozhen Wang, Zuowei Ning, Yang Li, Xiaoxin Ma, Renqiang Yang, Siyi Jin, Yun Huang, Ying Meng, Xu Li
Aldosterone, with pro-oxidation and pro-autophagy capabilities, plays a key role in liver fibrosis. However, the mechanisms underlying aldosterone-promoted liver sinusoidal endothelial cells (LSECs) defenestration remain unknown. Caveolin 1 (Cav1) displays close links with autophagy and fenestration. Hence, we aim to investigate the role of Cav1-related autophagy in LSECs defenestration. We found the increase of aldosterone/MR (mineralocorticoid receptor) level, oxidation, autophagy, and defenestration in LSECs in the human fibrotic liver, BDL or hyperaldosteronism models; while antagonizing aldosterone or inhibiting autophagy relieved LSECs defenestration in BDL-induced fibrosis or hyperaldosteronism models...
July 13, 2017: Redox Biology
https://www.readbyqxmd.com/read/28734241/entrapment-perceived-burdensomeness-and-thwarted-belongingness-as-predictors-of-suicide-ideation
#2
Thomas Forkmann, Tobias Teismann
The Integrated Motivational-Volitional (IMV) Model of suicide posits that perceived burdensomeness and thwarted belongingness moderate the association between perceptions of entrapment and suicide ideation. However, the proposed moderation is yet to be tested. Possible moderator effects were investigated in an online sample (N = 480; 74% female; Mage = 28.5, SDage = 11.1). Entrapment and perceived burdensomeness predicted suicide ideation. However, neither perceived burdensomeness nor thwarted belongingness moderated the association between entrapment and suicide ideation...
July 16, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28734195/implementation-of-psychological-clinical-trials-in-epilepsy-review-and-guide
#3
REVIEW
Avani C Modi, Janelle Wagner, Aimee W Smith, Tanja S Kellermann, Rosa Michaelis
The International League Against Epilepsy (ILAE) Neuropsychiatry commission and United States Institute of Medicine report both identified cognitive and psychological comorbidities as a significant issue for individuals with epilepsy, with rates as high as 60%. However, there is a paucity of evidence-based treatments for many psychological conditions (e.g., learning disorders, cognitive disorders, behavioral disorders). Because of inherent challenges in the implementation of psychological therapy trials and specific considerations for the population with epilepsy, the focus of the current review was to provide guidance and recommendations to conduct psychological trials for individuals with epilepsy...
July 19, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28734176/cancer-immunotherapy-moving-forward-with-peptide-t-cell-vaccines
#4
REVIEW
Takumi Kumai, Aaron Fan, Yasuaki Harabuchi, Esteban Celis
Recent advances in cancer immunology, such as the discovery of immune checkpoint inhibitors, have validated immune cells as potential key players for effective cancer treatment. The efficacy of these therapies seems to be codependent on a tumor-reactive T lymphocyte response. For many years, numerous attempts and strategies in developing vaccines to generate tumor-reactive T cells have yielded poor results in the clinic due to suboptimal immunogenicity and the inability to overcome an immunosuppressive tumor microenvironment...
July 19, 2017: Current Opinion in Immunology
https://www.readbyqxmd.com/read/28734140/deregulation-of-levels-of-angiopoietin-1-and-angiopoietin-2-is-associated-with-severe-courses-of-hantavirus-infection
#5
Christian Nusshag, Anja Osberghaus, Alexandra Baumann, Paul Schnitzler, Martin Zeier, Ellen Krautkrämer
BACKGROUND: Hantavirus disease is characterized by endothelial dysfunction. Angiopoietin-1 (Ang-1) and its antagonist angiopoietin-2 (Ang-2) play a key role in the control of capillary permeability. Ang-1 is responsible for maintenance of cell-to-cell contacts whereas Ang-2 destabilizes monolayers. An imbalance of Ang-1 and Ang-2 levels results in enhanced permeability and capillary leakage. OBJECTIVES: To analyze the involvement of angiopoietins in hantavirus-induced disruption of endothelia, we measured the levels of Ang-1 and Ang-2 in hantavirus infection...
July 11, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/28734135/folding-while-bound-to-chaperones
#6
REVIEW
Scott Horowitz, Philipp Koldewey, Frederick Stull, James Ca Bardwell
Chaperones are important in preventing protein aggregation and aiding protein folding. How chaperones aid protein folding remains a key question in understanding their mechanism. The possibility of proteins folding while bound to chaperones was reintroduced recently with the chaperone Spy, many years after the phenomenon was first reported with the chaperones GroEL and SecB. In this review, we discuss the salient features of folding while bound in the cases for which it has been observed and speculate about its biological importance and possible occurrence in other chaperones...
July 19, 2017: Current Opinion in Structural Biology
https://www.readbyqxmd.com/read/28734128/the-experience-of-initiating-injection-drug-use-and-its-social-context-a-qualitative-systematic-review-and-thematic-synthesis
#7
REVIEW
Andy Guise, Danielle Horyniak, Jason Melo, Ryan McNeill, Dan Werb
BACKGROUND AND AIM: Understanding the experience of initiating injection drug use and its social contexts is crucial to inform efforts to prevent transitions into this mode of drug consumption and support harm reduction. We systematically reviewed and synthesized existing qualitative scientific literature to identify the socio-structural contexts for, and experiences of, the initiation of injection drug use. METHODS: We systematically searched six databases (Medline, Embase, PsychINFO, CINAHL, IBSS, and SSCI), along with a manual search, including of key journals and subject experts...
July 22, 2017: Addiction
https://www.readbyqxmd.com/read/28734115/regularized-estimation-in-sparse-high-dimensional-multivariate-regression-with-application-to-a-dna-methylation-study
#8
Haixiang Zhang, Yinan Zheng, Grace Yoon, Zhou Zhang, Tao Gao, Brian Joyce, Wei Zhang, Joel Schwartz, Pantel Vokonas, Elena Colicino, Andrea Baccarelli, Lifang Hou, Lei Liu
In this article, we consider variable selection for correlated high dimensional DNA methylation markers as multivariate outcomes. A novel weighted square-root LASSO procedure is proposed to estimate the regression coefficient matrix. A key feature of this method is tuning-insensitivity, which greatly simplifies the computation by obviating cross validation for penalty parameter selection. A precision matrix obtained via the constrained ℓ1 minimization method is used to account for the within-subject correlation among multivariate outcomes...
July 26, 2017: Statistical Applications in Genetics and Molecular Biology
https://www.readbyqxmd.com/read/28732351/tropomyosin-isoform-tpm2-1-regulates-collective-and-amoeboid-cell-migration-and-cell-aggregation-in-breast-epithelial-cells
#9
HyeRim Shin, Dayoung Kim, David M Helfman
Metastasis dissemination is the result of various processes including cell migration and cell aggregation. These processes involve alterations in the expression and organization of cytoskeletal and adhesion proteins in tumor cells. Alterations in actin filaments and their binding partners are known to be key players in metastasis. Downregulation of specific tropomyosin (Tpm) isoforms is a common characteristic of transformed cells. In this study, we examined the role of Tpm2.1 in non-transformed MCF10A breast epithelial cells in cell migration and cell aggregation, because this isoform is downregulated in primary and metastatic breast cancer as well as various breast cancer cell lines...
July 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/28732340/vascular-regulation-of-glioma-stem-like-cells-a-balancing-act
#10
REVIEW
Lucy J Brooks, Simona Parrinello
Glioblastoma (GBM) are aggressive and therapy-resistant brain tumours driven by glioma stem-like cells (GSCs). GSC behaviour is controlled by the microenvironment, or niche, in which the cells reside. It is well-established that the vasculature is a key component of the GSC niche, which drives maintenance in the tumour bulk and invasion at the margin. Emerging evidence now indicates that the specific properties of the vasculature within these two regions impose different functional states on resident GSCs, generating distinct subpopulations...
July 18, 2017: Current Opinion in Neurobiology
https://www.readbyqxmd.com/read/28732333/p-nitrophenol-degradation-by-electro-fenton-process-pathway-kinetic-model-and-optimization-using-central-composite-design
#11
J Meijide, E Rosales, M Pazos, M A Sanromán
The chemical process scale-up, from lab studies to industrial production, is challenging and requires deep knowledge of the kinetic model and the reactions that take place in the system. This knowledge is also useful in order to be employed for the reactor design and the determination of the optimal operational conditions. In this study, a model substituted phenol such as p-nitrophenol was degraded by electro-Fenton process and the reaction products yielded along the treatment were recorded. The kinetic model was developed using Matlab software and was based on main reactions that occurred until total mineralization which allowed predicting the degradation pathway under this advanced oxidation process...
July 14, 2017: Chemosphere
https://www.readbyqxmd.com/read/28732330/legacy-persistent-organic-pollutants-including-pbdes-in-the-trophic-web-of-the-ross-sea-antarctica
#12
Simonetta Corsolini, Nicoletta Ademollo, Tania Martellini, Demetrio Randazzo, Marino Vacchi, Alessandra Cincinelli
The ecological features of the Ross Sea trophic web are peculiar and different from other polar food webs, with respect to the use of habitat and species interactions; due to its ecosystem integrity, it is the world's largest Marine Protected Area, established in 2016. Polar organisms are reported to bioaccumulate lipophilic contaminant, viz persistent organic pollutants (POPs). Legacy POPs and flame retardants (polybrominated diphenyl ethers, PBDEs) were studied in key species of the Ross Sea (Euphausia superba, Pleuragramma antarctica) and their predators (Dissostichus mawsoni, Pygoscelis adeliae, Aptenodytes forsteri, Catharacta maccormicki, Leptonychotes weddellii)...
July 12, 2017: Chemosphere
https://www.readbyqxmd.com/read/28732280/evaluation-of-a-novel-median-power-spectrogram-for-seizure-detection-by-non-neurophysiologists
#13
Peter Yan, Tamar Melman, Sherry Yan, Munkhzul Otgonsuren, Zachary Grinspan
PURPOSE: (1) To evaluate how well resident physicians use a novel EEG spectral analysis tool (the median power spectrogram; MPS) to detect seizures. (2) To assess the capability of the MPS to identify different seizure types. METHODS: 120 EEG records from children with intractable seizures were converted to MPS by taking the median power across leads and using multi-taper spectral estimation. Twelve blinded neurology residents were trained to interpret the spectrogram with a five-minute video tutorial and post-test...
June 15, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28732244/thyroglossal-duct-cysts-in-children-sonographic-features-every-radiologist-should-know-and-their-histopathological-correlation
#14
REVIEW
Emilio Inarejos Clemente, Modupe Oyewumi, Evan Probst, Bo-Yee Ngan, Mary-Louise Greer
Distinguishing between thyroglossal duct cysts (TGDC) and dermoid cysts (DC) sonographically can be challenging. We illustrate the three sonographic features in neck masses in children recently identified as being most suggestive of TGDC (septa, irregular wall and solid elements) and their corresponding histopathology. These three variables form a proposed predictive model for TGDC as a guide to surgical intervention. Pediatric radiologists should be familiar with these key imaging features, as compared with other imaging features described in TGDC also illustrated here, which are less discriminating...
July 12, 2017: Clinical Imaging
https://www.readbyqxmd.com/read/28732193/what-should-a-website-dedicated-to-the-postnatal-period-contain-a-delphi-survey-among-parents-and-professionals
#15
J Slomian, P Emonts, M Erpicum, L Vigneron, J Y Reginster, O Bruyère
OBJECTIVES: Mothers have a great need for information during the postnatal period. Trying to meet this need, mothers are increasingly turning to the Internet. Nevertheless, many women have stated that they often or always found that the information that they found on the Internet was incomplete or wrong. Many women therefore believe that health professionals should suggest reliable Internet websites for new mothers. The aim of this study was therefore to find a consensus on the content of a reliable and centralized website dedicated to mothers from the end of pregnancy to 1 year after childbirth...
July 6, 2017: Midwifery
https://www.readbyqxmd.com/read/28732184/high-throughput-identification-of-mir-596-inducing-p53-mediated-apoptosis-in-hela-and-hct116-cells-using-cell-microarray
#16
Ming Ma, Junyu Yang, Bolun Wang, Zhihua Zhao, Jianzhong Jeff Xi
miRNAs play a key role in the regulation of gene networks in mammalian cells. However, little is known about their roles and functions in the apoptosis pathway. Here, we conducted a whole-genome miRNA screening for apoptosis and identified more than 100 miRNAs as apoptosis inducers. To further explain the roles of these mRNAs in apoptosis, a second round of screening was conducted between p53 +/+ and -/- cells. Among the hits, miR-596 was identified as a regulator of p53. The overexpression of miR-596 significantly increased p53 at the protein level, thereby inducing apoptosis...
July 1, 2017: SLAS Technology
https://www.readbyqxmd.com/read/28732152/secukinumab-in-the-treatment-of-psoriasis-and-psoriatic-arthritis-a-review-of-the-literature
#17
M Abrouk, J Gandy, M Nakamura, K Lee, M Brodsky, R Singh, H Zhu, B Farahnik, T Bhutani, J Koo
While there are several commercially available treatment options for psoriasis and psoriatic arthritis, there remains a large number of individuals who are refractory to current modalities. In the recent past, there has been increasing evidence that interleukin (IL)-17 plays a vital role in the pathophysiology of psoriasis. Preclinical, phase II, and phase III studies of secukinumab (Cosentyx®) targeting IL-17 and its receptor have thus far proved to be promising. We reviewed the results of phase II and phase III clinical trials for secukinumab in the treatment of psoriasis and psoriatic arthritis...
July 2017: Skin Therapy Letter
https://www.readbyqxmd.com/read/28732142/network-meta-analysis-including-treatment-by-covariate-interactions-consistency-can-vary-across-covariate-values
#18
Sarah Donegan, Nicky J Welton, Catrin Tudur Smith, Umberto D'Alessandro, Sofia Dias
BACKGROUND: Many reviews aim to compare numerous treatments and report results stratified by subgroups (e.g. by disease severity). In such cases, a network meta-analysis model including treatment by covariate interactions can estimate the relative effects of all treatment pairings for each subgroup of patients. Two key assumptions underlie such models, consistency of treatment effects and consistency of the regression coefficients for the interactions. Consistency may differ depending on the covariate value at which consistency is assessed...
July 21, 2017: Research Synthesis Methods
https://www.readbyqxmd.com/read/28732125/birth-preparedness-and-complication-readiness-among-prenatal-attendees-in-a-teaching-hospital-in-south-west-nigeria
#19
Olusola P Aduloju, Akinyemi A Akintayo, Tolulope Aduloju, Oladunni O Akin-Akintayo
OBJECTIVE: To assess birth preparedness and complication readiness (BPCR) as well as knowledge of danger signs during pregnancy, labor/delivery, and the postpartum period. METHODS: A cross-sectional study was undertaken of pregnant women attending the prenatal clinic at a tertiary hospital in Nigeria between October and December 2016. A pretested and structured questionnaire was used to collect data on BPCR, and logistic regression was performed to determine factors affecting BPCR...
July 21, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28732097/resources-for-lshss-authors
#20
Shelley Gray
In this article, the Editor-in-Chief of Language, Speech, and Hearing Services in Schools (LSHSS) highlights key resources for authors wishing to publish their work in LSHSS.
July 21, 2017: Language, Speech, and Hearing Services in Schools
keyword
keyword
31978
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"