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https://www.readbyqxmd.com/read/28719860/liposome-modified-titanium-surface-a-strategy-to-locally-deliver-bioactive-molecules
#1
Vincenzo De Leo, Monica Mattioli-Belmonte, Maria Teresa Cimmarusti, Annamaria Panniello, Manuela Dicarlo, Francesco Milano, Angela Agostiano, Elvira De Giglio, Lucia Catucci
Titanium and its alloys are widely employed materials for implants in orthopedic or dental surgery due to their mechanical properties, resistance to corrosion and osseointegration capability. However adverse reactions at the tissue/implant interface may occur, which limit the success of the osseointegration process. Therefore, different strategies have to be used to overcome these drawbacks. In this work, we developed two different liposome-based coatings on titanium surfaces as drug or bioactive molecule deposits for dental/orthopedic implant applications...
July 8, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28719856/contribution-of-kupffer-cells-to-liposome-accumulation-in-the-liver
#2
Emma Samuelsson, Haifa Shen, Elvin Blanco, Mauro Ferrari, Joy Wolfram
The liver is a major barrier for site-specific delivery of systemically injected nanoparticles, as up to 90% of the dose is usually captured by this organ. Kupffer cells are thought to be the main cellular component responsible for nanoparticle accumulation in the liver. These resident macrophages form part of the mononuclear phagocyte system, which recognizes and engulfs foreign bodies in the circulatory system. In this study, we have compared two strategies for reducing nanoparticle accumulation in the liver, in order to investigate the specific contribution of Kupffer cells...
July 15, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28719650/heat-stimuli-enhanced-osteogenesis-using-clinically-available-biomaterials
#3
Takehiro Ota, Yoshihiro Nishida, Kunihiro Ikuta, Ryuji Kato, Eiji Kozawa, Shunsuke Hamada, Tomohisa Sakai, Naoki Ishiguro
A recent study reported that heat stress stimulates osteogenesis in an in vivo rat model using alginate gel and magnetite cationic liposomes. However, for clinical use, the efficacy for promoting osteogenesis needs to be investigated using clinically approved materials, and preferably with animals larger than rats. The aim of this study was to evaluate multiple heat stimuli-triggered osteogenesis in rat tibial defect models using already clinically applicable materials (Resovist® and REGENOS®) and determine the efficacy also in the rabbit...
2017: PloS One
https://www.readbyqxmd.com/read/28716758/oral-delivery-of-vancomycin-by-tetraether-lipid-liposomes
#4
Philipp Uhl, Silvia Pantze, Philip Storck, Johannes Parmentier, Dominik Witzigmann, Götz Hofhaus, Jörg Huwyler, Walter Mier, Gert Fricker
Despite the outstanding progress in modern medicine, the oral delivery of peptide drugs is limited until today due to their instability in the gastrointestinal tract and low mucosa penetration. To overcome these hurdles, liposomes containing the specific tetraether lipid GCTE (glycerylcaldityltetraether lipid) were examined. For this purpose, the glycopeptide antibiotic vancomycin was used as model substance and liposomes were prepared by DAC (dual assymetric centrifugation). These liposomes showed a size and polydispersity index comparable to standard liposomes...
July 14, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28716129/current-knowledge-on-feline-injection-site-sarcoma-treatment
#5
REVIEW
Katarzyna Zabielska-Koczywąs, Anna Wojtalewicz, Roman Lechowski
Feline injection-site sarcomas (FISS) are malignant skin tumours of mesenchymal origin, the treatment of which is a challenge for veterinary surgeons. The role of surgery, radiotherapy and chemotherapy in FISS treatment has been studied, and a correlation between "clean" surgical margins and disease-free survival has been shown. In addition, clean surgical margins are one of the most important factors for achieving a low recurrence rate. The most effective method of FISS treatment includes combining radical surgery with pre- or postoperative radiotherapy...
July 17, 2017: Acta Veterinaria Scandinavica
https://www.readbyqxmd.com/read/28716069/angiosarcoma-treated-successfully-with-anti-pd-1-therapy-a-case-report
#6
Simran Sindhu, Lana H Gimber, Lee Cranmer, Ali McBride, Andrew S Kraft
BACKGROUND: Angiosarcomas are tumors of malignant endothelial origin that have a poor prognosis with a five-year survival of less than 40%. These tumors can be found in all age groups, but are more common in older patients; with the cutaneous form most common in older white men. Combined modality therapy including surgery and radiation appears to have a better outcome than each modality alone. When metastatic, agents such as liposomal doxorubicin, paclitaxel and ifosfamide have activity but it is short-lived and not curative...
July 18, 2017: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/28715634/a-novel-strategy-utilizing-extracellular-cysteine-rich-domain-of-membrane-receptor-for-constructing-d-peptide-mediated-targeted-drug-delivery-systems-a-case-study-on-fn14
#7
Zhuoxuan Li, Jing Xie, Shan Peng, Sha Liu, Ying Wang, Weiyue Lu, Jie Shen, Chong Li
The development of proteolysis-resistant D-peptide ligands for targeted drug/gene delivery has been greatly limited, due to the challenge lies in the chemical synthesis of membrane receptors without altering their structures. In the present research, a novel strategy utilizing self-stabilized extracellular cysteine-rich domain (CRD) of membrane receptor was developed to construct D-peptide ligands and their mediated targeted drug delivery systems. Fibroblast growth factor-inducible 14 (Fn14), a cell surface receptor overexpressed in many cancers including pancreatic and triple-negative breast cancers, was selected as the model receptor...
July 17, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28715002/cationic-folate-mediated-liposomal-delivery-of-bis-arylidene-oxindole-induces-efficient-melanoma-tumor-regression
#8
Chandra Kumar Elechalawar, Kathyayani Sridharan, Abhishek Pal, Mohammed Tanveer Ahmed, Mohammed Yousuf, Susanta Sekhar Adhikari, Rajkumar Banerjee
The folate receptor (FR) is a well-validated and common target for cancer due to its high over-expression in many different cancer cells. Herein, we developed a new FR-targeting ligand (FA8) by conjugating folic acid and a cationic lipid. Owing to its favorable structural property FA8 as a ligand could be accommodated at an unusually higher molar ratio for a ligand-targeted liposome. We then encapsulated a drug-like molecule, bis-arylidene oxindole (NME2), in the targeted liposome. The resulting formulation induced potent caspase-8 up-regulation even in FR-moderately expressing melanoma cells...
July 17, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28714873/a-label-free-fluorescent-array-sensor-utilizing-liposome-encapsulating-calcein-for-discriminating-target-proteins-by-principal-component-analysis
#9
Ryota Imamura, Naoki Murata, Toshinori Shimanouchi, Kaoru Yamashita, Masayuki Fukuzawa, Minoru Noda
A new fluorescent arrayed biosensor has been developed to discriminate species and concentrations of target proteins by using plural different phospholipid liposome species encapsulating fluorescent molecules, utilizing differences in permeation of the fluorescent molecules through the membrane to modulate liposome-target protein interactions. This approach proposes a basically new label-free fluorescent sensor, compared with the common technique of developed fluorescent array sensors with labeling. We have confirmed a high output intensity of fluorescence emission related to characteristics of the fluorescent molecules dependent on their concentrations when they leak from inside the liposomes through the perturbed lipid membrane...
July 15, 2017: Sensors
https://www.readbyqxmd.com/read/28713368/the-sptransformer-gene-family-formerly-sp185-333-in-the-purple-sea-urchin-and-the-functional-diversity-of-the-anti-pathogen-rsptransformer-e1-protein
#10
REVIEW
L Courtney Smith, Cheng Man Lun
The complex innate immune system of sea urchins is underpinned by several multigene families including the SpTransformer family (SpTrf; formerly Sp185/333) with estimates of ~50 members, although the family size is likely variable among individuals of Strongylocentrotus purpuratus. The genes are small with similar structure, are tightly clustered, and have several types of repeats in the second of two exons and that surround each gene. The density of repeats suggests that the genes are positioned within regions of genomic instability, which may be required to drive sequence diversification...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28712122/clinical-features-and-treatment-response-of-cutaneous-leishmaniasis-in-north-west-ethiopia
#11
Helina Fikre, Rezika Mohammed, Saba Atinafu, Johan van Griensven, Ermias Diro
OBJECTIVE: Cutaneous leishmaniasis (CL) receives far less attention than visceral leishmaniasis. Nevertheless, CL is predominantly caused by a unique species in Ethiopia (L aethiopica), which is known to cause severe forms such as diffuse (DCL) and mucocutaneous leishmaniasis (MCL). We report on the number and type of CL cases diagnosed, the clinical features, the treatments and treatment outcomes in North-West Ethiopia. METHODS: This is a retrospective chart record analysis of CL patients treated at the Leishmania Research and Treatment Center (LRTC) of the University of Gondar, Ethiopia...
July 16, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/28709962/the-role-of-macrophages-in-the-development-of-biliary-injury-in-a-lipopolysaccharide-aggravated-hepatic-ischaemia-reperfusion-model
#12
REVIEW
J Reiling, K R Bridle, F G Schaap, L Jaskowski, N Santrampurwala, L J Britton, C M Campbell, P L M Jansen, S W M Olde Damink, D H G Crawford, C H C Dejong, J Fawcett
INTRODUCTION: Endotoxins, in the form of lipopolysaccharides (LPS), are potent inducers of biliary injury. However the mechanism by which injury develops remains unclear. We hypothesized that hepatic macrophages are pivotal in the development of endotoxin-induced biliary injury and that no injury would occur in their absence. MATERIAL AND METHODS: Clodronate liposomes were used to deplete macrophages from the liver. Forty-eight rats were equally divided across six study groups: sham operation (sham), liposome treatment and sham operation (liposomes+sham), 1mg/kg LPS i...
July 11, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28708440/model-calculations-of-regional-deposition-and-disposition-for-single-doses-of-inhaled-liposomal-and-dry-powder-ciprofloxacin
#13
Andrew R Martin, Warren H Finlay
BACKGROUND: Model predictions of regional deposition in the respiratory tract are useful in assessing factors that influence the effectiveness of aerosol delivery. Regional deposition models have previously been coupled with models of mucous production and clearance to estimate initial concentrations of drug deposited in the airway surface liquid (ASL) lining tracheobronchial airways. METHODS: Established models of regional deposition and ASL volumes were used to provide input to a new model evaluating the disposition of drug resulting from dissolution or release, absorption, and mucociliary clearance...
July 14, 2017: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/28708392/thiol-triggered-release-of-intraliposomal-content-from-liposomes-made-of-extremophile-inspired-tetraether-lipids
#14
Takaoki Koyanagi, Jessica L Cifelli, Geoffray Leriche, David Onofrei, Gregory P Holland, Jerry Yang
Liposomal drug delivery systems have been used for delivery of drugs to targeted tissues while reducing unwanted side effects. DOXIL®, for instance, is a liposomal formulation of the anti-cancer agent doxorubicin (DOX) that has been used to address problems associated with non-specific toxicity of free DOX. However, while this liposomal formulation allows for a more stable circulation of doxorubicin in the body compared with free drug, efficacy for cancer therapy is reduced when compared with systemic injections of free drug...
July 14, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28707883/non-invasive-and-highly-selective-monitoring-of-intracellular-glucose-via-two-steps-recognition-based-nanokit
#15
Jianru Tang, Dandan Ma, Stevan Pecic, Caixia Huang, Jing Zheng, Jishan Li, Ronghua Yang
Accurate determination of intracellular glucose is very important for exploring its chemical and biological functions in metabolism events of living cells. In this paper, we developed a new non-invasive and highly selective nanokit for intracellular glucose monitoring via two steps recognition. The liposome-based nanokit coencapsulated the aptamer-functionalized gold nanoparticles (AuNPs) and the Shinkai's receptor together. Upon the proposed nanokit was transfected into living cells, the Shinkai's receptor could recognize glucose firstly and then changed its conformation to endow aptamers with binding and sensing properties which are not readily accessible otherwise...
July 14, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28707264/evaluation-of-propylene-glycol-nanoliposomes-containing-curcumin-on-burn-wound-model-in-rat-biocompatibility-wound-healing-and-anti-bacterial-effects
#16
Nooshin Kianvash, Abbas Bahador, Maryam Pourhajibagher, Homanaz Ghafari, Vahid Nikoui, Sayed Mehdi Rezayat, Ahmad Reza Dehpour, Alireza Partoazar
Curcumin is an effective wound healing agent in burn therapy, but due to its low bioavailability, it is required to be formulated for topical therapy. Liposomal nanocarriers are developed as stable and efficient dermal delivery systems. In this study, we prepared curcumin-propylene glycol liposomes (Cur-PgL) to treat animals subjected to second degree burns. The characterization tests confirmed the production of monodisperse nanoliposomes of average size of about 145 nm with high entrapment efficiency percentage and a sustained release behavior...
July 13, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/28706969/quantitative-analysis-of-immune-cell-subset-infiltration-of-supraspinatus-muscle-after-severe-rotator-cuff-injury
#17
J R Krieger, L E Tellier, M T Ollukaren, J S Temenoff, E A Botchwey
Rotator cuff tears cause muscle degeneration that is characterized by myofiber atrophy, fatty infiltration, and fibrosis and is minimally responsive to current treatment options. The underlying pathogenesis of rotator cuff muscle degeneration remains to be elucidated, and increasing evidence implicates immune cell infiltration as a significant factor. Because immune cells are comprised of highly heterogeneous subpopulations that exert divergent effects on injured tissue, understanding trafficking and accumulation of immune subpopulations may hold the key to more effective therapies...
June 2017: Regenerative Engineering and Translational Medicine
https://www.readbyqxmd.com/read/28705043/mannosylated-liposomes-improve-therapeutic-effects-of-paclitaxel-in-colon-cancer-models
#18
Menghua Xiong, Qian Lei, Xinyu You, Tiantao Gao, Xuejiao Song, Yong Xia, Tinghong Ye, Lidan Zhang, Ningyu Wang, Luoting Yu
Mannose receptor (MR) is a highly effective endocytic receptor. It is closely related to tumor immune escape and metastasis. We found that MR was highly expressed in some colon cancer cell lines such as CT26 and HCT116 cells. Therefore MR might be a potential target in colon cancer therapy. In this study, we aimed to develop mannosylated liposomes containing anticancer drug paclitaxel (PTX) and investigate the potential effects on targeted therapy for colon cancer. Mannosylated liposomes were prepared by film dispersion method...
July 14, 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/28704679/ph-sensitive-polymer-modified-liposome-based-immunity-inducing-system-effects-of-inclusion-of-cationic-lipid-and-cpg-dna
#19
Yuta Yoshizaki, Eiji Yuba, Naoki Sakaguchi, Kazunori Koiwai, Atsushi Harada, Kenji Kono
Efficient vaccine carriers for cancer immunotherapy require two functions: antigen delivery to dendritic cells (DCs) and the activation of DCs, a so-called adjuvant effect. We previously reported antigen delivery system using liposomes modified with pH-sensitive polymers, such as 3-methylglutarylated hyperbranched poly(glycidol) (MGlu-HPG), for the induction of antigen-specific immune responses. We reported that inclusion of cationic lipids to MGlu-HPG-modified liposomes activates DCs and enhances antitumor effects...
July 3, 2017: Biomaterials
https://www.readbyqxmd.com/read/28704436/platinum-nanoparticles-induce-damage-to-dna-and-inhibit-dna-replication
#20
Lukas Nejdl, Jiri Kudr, Amitava Moulick, Dagmar Hegerova, Branislav Ruttkay-Nedecky, Jaromir Gumulec, Kristyna Cihalova, Kristyna Smerkova, Simona Dostalova, Sona Krizkova, Marie Novotna, Pavel Kopel, Vojtech Adam
Sparsely tested group of platinum nanoparticles (PtNPs) may have a comparable effect as complex platinum compounds. The aim of this study was to observe the effect of PtNPs in in vitro amplification of DNA fragment of phage λ, on the bacterial cultures (Staphylococcus aureus), human foreskin fibroblasts and erythrocytes. In vitro synthesized PtNPs were characterized by dynamic light scattering (PtNPs size range 4.8-11.7 nm), zeta potential measurements (-15 mV at pH 7.4), X-ray fluorescence, UV/vis spectrophotometry and atomic absorption spectrometry...
2017: PloS One
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