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https://www.readbyqxmd.com/read/28938689/efficacy-and-safety-of-traditional-chemotherapies-for-patients-with-ovarian-neoplasm-a-network-meta-analysis
#1
REVIEW
Lili Yang, Gongliang Guo, Liqun Sun, Chenhao Li, Haipeng Zhang
BACKGROUND: Ovarian neoplasm is a kind of high risky cancer among female. This paper assessed the efficacy and safety of twelve therapies and figured out the superior chemotherapeutic drug for ovarian cancer through network meta-analysis (NMA). METHOD: Eligible randomized controlled trials (RCTs) were retrieved from electronic databases. Primary outcomes concerning efficacy, overall survival (OS) and progression-free survival (PFS), were presented as hazard ratio (HR) and the associated 95% credible interval(CrI), while outcomes concerning safety were assessed by odds ratio (OR) and the corresponding 95% CrI...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28937646/effects-of-liposomes-contained-in-thermosensitive-hydrogels-as-biomaterials-useful-in-neural-tissue-engineering
#2
Yusser Olguín, Cristian Campos, Javiera Catalán, Luís Velásquez, Fernando Osorio, Iván Montenegro, Alejandro Madrid, Cristian Acevedo
Advances in the generation of suitable thermosensitive hydrogels for the delivery of cells in neural tissue engineering demonstrate a delicate relationship between physical properties and capabilities to promote cell proliferation and differentiation. To improve the properties of these materials, it is possible to add liposomes for the controlled release of bioactive elements, which in turn can affect the physical and biological properties of the hydrogels. In the present investigation, different hydrogels based on Pluronic F127 have been formulated with the incorporation of chitosan and two types of liposomes of two different sizes...
September 22, 2017: Materials
https://www.readbyqxmd.com/read/28937321/enhancement-of-radiotherapy-efficacy-by-pleiotropic-liposomes-encapsulated-paclitaxel-and-perfluorotributylamine
#3
Xing Jiang, Baoli Zhang, Zaigang Zhou, Lingtong Meng, Zhiling Sun, Yun Xu, Qiuping Xu, Ahu Yuan, Lixia Yu, Hanqing Qian, Jinhui Wu, Yiqiao Hu, Baorui Liu
Paclitaxel (PTX) is widely used as a radiosensitizer in the clinical treatment of cancer. However, the efficacy of chemoradiotherapy is limited by the hostility of the tumor microenvironment such as hypoxia. To overcome this constraint, we designed pleiotropic radiotherapy sensitized liposomes containing perfluorotributylamine (PFTBA) and PTX. The results showed that liposomes significantly accumulated in the tumor site. PFTBA in liposomes dramatically reversed tumor hypoxia and improved the sensitivity of tumor radiotherapy...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28937293/enhancing-tumor-specific-immune-responses-by-transcutaneous-vaccination
#4
Hanadi Saliba, Béatrice Heurtault, Hasnaa Bouharoun-Tayoun, Vincent Flacher, Benoît Frisch, Sylvie Fournel, Soulaima Chamat
Introduction Our understanding of the involvement of the immune system in cancer control has increased over recent years. However, the development of cancer vaccines intended to reverse tumor-induced immune tolerance remains slow as most current vaccine candidates exhibit limited clinical efficacy. The skin is particularly rich with multiple subsets of dendritic cells (DCs) that are involved to varying degrees in the induction of robust immune responses. Transcutaneous administration of cancer vaccines may therefore harness the immune potential of these DCs, however, this approach is hampered by the impermeability of the stratum corneum...
September 22, 2017: Expert Review of Vaccines
https://www.readbyqxmd.com/read/28936360/robust-antibody-and-cd8-t-cell-responses-induced-by-p-falciparum-csp-adsorbed-to-cationic-liposomal-adjuvant-caf09-confer-sterilizing-immunity-against-experimental-rodent-malaria-infection
#5
Diego A Espinosa, Dennis Christensen, Christian Muñoz, Sanjay Singh, Emily Locke, Peter Andersen, Fidel Zavala
Despite several decades of extensive research, the development of a highly efficacious malaria vaccine has yet to be accomplished. While the RTS,S malaria vaccine candidate shows the potential to prevent a substantial number of clinical malaria cases, significant improvements in protective efficacy are still needed. Multiple studies have shown that RTS,S induces protective antibody and CD4(+) T-cell responses, but limited or negligible CD8(+) T cells. In this study, we evaluated the immunogenicity and protective capacity of full-length recombinant P...
2017: NPJ Vaccines
https://www.readbyqxmd.com/read/28935937/membrane-tension-increases-fusion-efficiency-of-model-membranes-in-the-presence-of-snares
#6
Torben-Tobias Kliesch, Jörn Dietz, Laura Turco, Partho Halder, Elena Polo, Marco Tarantola, Reinhard Jahn, Andreas Janshoff
The large gap in time scales between membrane fusion occurring in biological systems during neurotransmitter release and fusion observed between model membranes has provoked speculations over a large number of possible factors that might explain this discrepancy. One possible reason is an elevated lateral membrane tension present in the presynaptic membrane. We investigated the tension-dependency of fusion using model membranes equipped with a minimal fusion machinery consisting of syntaxin 1, synaptobrevin and SNAP 25...
September 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28935923/formation-and-purification-of-tailored-liposomes-for-drug-delivery-using-a-module-based-micro-continuous-flow-system
#7
Nikolay Dimov, Elisabeth Kastner, Maryam Hussain, Yvonne Perrie, Nicolas Szita
Liposomes are lipid based bilayer vesicles that can encapsulate, deliver and release low-soluble drugs and small molecules to a specific target site in the body. They are currently exploited in several nanomedicine formulations. However, their development and application is still limited by expensive and time-consuming process development and production methods. Therefore, to exploit these systems more effectively and support the rapid translation of new liposomal nanomedicines from bench to bedside, new cost-effective and scalable production methods are needed...
September 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28935572/macrophage-infiltration-is-a-causative-factor-for-ligamentum-flavum-hypertrophy-through-the-activation-of-collagen-production-in-fibroblasts
#8
Takeyuki Saito, Masamitsu Hara, Hiromi Kumamaru, Kazu Kobayakawa, Kazuya Yokota, Ken Kijima, Shingo Yoshizaki, Katsumi Harimaya, Yoshihiro Matsumoto, Kenichi Kawaguchi, Mitsumasa Hayashida, Yutaka Inagaki, Keiichiro Shiba, Yasuharu Nakashima, Seiji Okada
Ligamentum flavum (LF) hypertrophy causes lumbar spinal canal stenosis, leading to leg pain and disability in activities of daily living in elderly individuals. Although there have been previous studies on LF hypertrophy, its pathomechanisms have not been fully elucidated. In this study, we demonstrated that infiltrating macrophages were a causative factor for LF hypertrophy. Induction of macrophages into the mouse LF by applying a micro-injury resulted in LF hypertrophy along with collagen accumulation and fibroblasts proliferation at the injured site, which were very similar to the characteristics observed in the severely hypertrophied LF of human...
September 18, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/28935273/a-multicenter-open-label-expanded-phase-2-study-to-evaluate-the-safety-and-efficacy-of-etirinotecan-pegol-a-polymer-conjugate-of-irinotecan-in-women-with-recurrent-platinum-resistant-or-refractory-ovarian-cancer
#9
G Rustin, I Vergote, J P Micha, L R Duska, N Reed, J Bendell, D Spitz, G Dark, U Hoch, M Tagliaferri, A L Hannah, A A Garcia
OBJECTIVE: Etirinotecan pegol (EP) is a novel polyethylene glycol conjugated form of irinotecan with documented activity in platinum-resistant ovarian cancer (PROC). We report the results of the expanded portion of a phase II study of EP in patients with PROC who received prior pegylated liposomal doxorubicin (PLD) or who were unable to receive it. METHODS: This multicenter, open-label, phase II study evaluated EP q21d for PROC. The primary endpoint was objective response rate (ORR) by Response Evaluation Criteria in Solid Tumors version 1...
September 18, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28934281/smart-thermosensitive-liposomes-for-effective-solid-tumor-therapy-and-in-vivo-imaging
#10
Kevin Affram, Ofonime Udofot, Mandip Singh, Sunil Krishnan, Renee Reams, Jens Rosenberg, Edward Agyare
In numerous studies, liposomes have been used to deliver anticancer drugs such as doxorubicin to local heat-triggered tumor. Here, we investigate: (i) the ability of thermosensitive liposomal nanoparticle (TSLnp) as a delivery system to deliver poorly membrane-permeable anticancer drug, gemcitabine (Gem) to solid pancreatic tumor with the aid of local mild hyperthermia and, (ii) the possibility of using gadolinium (Magnevist®) loaded-TSLnps (Gd-TSLnps) to increase magnetic resonance imaging (MRI) contrast in solid tumor...
2017: PloS One
https://www.readbyqxmd.com/read/28933837/a-quartz-crystal-microbalance-model-for-quantitatively-probing-the-deformation-of-adsorbed-particles-at-low-surface-coverage
#11
Jurriaan J J Gillissen, Joshua Alexander Jackman, Seyed R Tabaei, Bo Kyeong Yoon, Nam-Joon Cho
Characterizing the deformation of nanoscale, soft-matter particulates at solid-liquid interfaces is a demanding task, and there are limited experimental options to perform quantitative measurements in a non-perturbative manner. Previous attempts, based on the quartz crystal microbalance (QCM) technique, focused on the high surface coverage regime and modeled the adsorbed particles as a homogeneous film, while not considering the coupling between particles and surrounding fluid and hence resulting in an underestimation of the known particle height...
September 21, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28933723/artificial-lipid-membranes-past-present-and-future
#12
REVIEW
Christina G Siontorou, Georgia-Paraskevi Nikoleli, Dimitrios P Nikolelis, Stefanos K Karapetis
The multifaceted role of biological membranes prompted early the development of artificial lipid-based models with a primary view of reconstituting the natural functions in vitro so as to study and exploit chemoreception for sensor engineering. Over the years, a fair amount of knowledge on the artificial lipid membranes, as both, suspended or supported lipid films and liposomes, has been disseminated and has helped to diversify and expand initial scopes. Artificial lipid membranes can be constructed by several methods, stabilized by various means, functionalized in a variety of ways, experimented upon intensively, and broadly utilized in sensor development, drug testing, drug discovery or as molecular tools and research probes for elucidating the mechanics and the mechanisms of biological membranes...
July 26, 2017: Membranes
https://www.readbyqxmd.com/read/28932942/required-hydrophobicity-of-fluorescent-reporters-for-phosphatidylinositol-family-of-lipid-enzymes
#13
Jarod Waybright, Weigang Huang, Angela Proctor, Xiaoyang Wang, Nancy L Allbritton, Qisheng Zhang
The phosphatidylinositol (PtdIns) family of lipids plays important roles in cell differentiation, proliferation, and migration. Abnormal expression, mutation, or regulation of their metabolic enzymes has been associated with various human diseases such as cancer, diabetes, and bipolar disorder. Recently, fluorescent derivatives have increasingly been used as chemical probes to monitor either lipid localization or enzymatic activity. However, the requirements of a good probe have not been well defined, particularly modifications on the diacylglycerol side chain partly due to challenges in generating PtdIns lipids...
September 20, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28932762/liposome-disruption-assay-to-examine-lytic-properties-of-biomolecules
#14
John R Jimah, Paul H Schlesinger, Niraj H Tolia
Proteins may have three dimensional structural or amino acid features that suggest a role in targeting and disrupting lipids within cell membranes. It is often necessary to experimentally investigate if these proteins and biomolecules are able to disrupt membranes in order to conclusively characterize the function of these biomolecules. Here, we describe an in vitro assay to evaluate the membrane lytic properties of proteins and biomolecules. Large unilamellar vesicles (liposomes) containing carboxyfluorescein at fluorescence-quenching concentrations are treated with the biomolecule of interest...
August 5, 2017: Bio-protocol
https://www.readbyqxmd.com/read/28932760/membrane-lipid-screen-to-identify-molecular-targets-of-biomolecules
#15
John R Jimah, Paul H Schlesinger, Niraj H Tolia
Proteins that bind to and disrupt cell membranes may target specific phospholipids. Here we describe a protocol to identify the lipid targets of proteins and biomolecules. First, we describe a screen to identify lipids in membranes that are specifically bound by the biomolecule of interest. Second, we describe a method for determining if the presence of these lipids within membranes is necessary for membrane disruption. The methods described here were used to determine that the malaria vaccine candidate CelTOS disrupts cell membranes by specifically targeting phosphatidic acid (Jimah et al...
August 5, 2017: Bio-protocol
https://www.readbyqxmd.com/read/28932114/spermidine-mediated-poly-lactic-co-glycolic-acid-nanoparticles-containing-fluorofenidone-for-the-treatment-of-idiopathic-pulmonary-fibrosis
#16
Jing Tang, Jianming Li, Guo Li, Haitao Zhang, Ling Wang, Dai Li, Jinsong Ding
Idiopathic pulmonary fibrosis is a progressive, fatal lung disease with poor survival. The advances made in deciphering this disease have led to the approval of different antifibrotic molecules, such as pirfenidone and nintedanib. An increasing number of studies with particles (liposomes, nanoparticles [NPs], microspheres, nanopolymersomes, and nanoliposomes) modified with different functional groups have demonstrated improvement in lung-targeted drug delivery. In the present study, we prepared, characterized, and evaluated spermidine (Spd)-modified poly(lactic-co-glycolic acid) (PLGA) NPs as carriers for fluorofenidone (AKF) to improve the antifibrotic efficacy of this drug in the lung...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28932113/cationic-lipid-based-nanoparticles-mediate-functional-delivery-of-acetate-to-tumor-cells-in-vivo-leading-to-significant-anticancer-effects
#17
Leigh P Brody, Meliz Sahuri-Arisoylu, James R Parkinson, Harry G Parkes, Po Wah So, Nabil Hajji, E Louise Thomas, Gary S Frost, Andrew D Miller, Jimmy D Bell
Metabolic reengineering using nanoparticle delivery represents an innovative therapeutic approach to normalizing the deregulation of cellular metabolism underlying many diseases, including cancer. Here, we demonstrated a unique and novel application to the treatment of malignancy using a short-chain fatty acid (SCFA)-encapsulated lipid-based delivery system - liposome-encapsulated acetate nanoparticles for cancer applications (LITA-CAN). We assessed chronic in vivo administration of our nanoparticle in three separate murine models of colorectal cancer...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28931213/a-review-on-the-efficacy-and-toxicity-of-different-doxorubicin-nanoparticles-for-targeted-therapy-in-metastatic-breast-cancer
#18
REVIEW
Ayman Shafei, Wesam El-Bakly, Ahmed Sobhy, Omar Wagdy, Ahmed Reda, Omar Aboelenin, Amr Marzouk, Khalil El Habak, Randa Mostafa, Mahmoud A Ali, Mahmoud Ellithy
In metastatic breast cancer (MBC), the conventional doxorubicin (DOX) has various problems due to lack of selectivity with subsequent therapeutic failure and adverse effects. DOX- induced cardiotoxicity is a major problem that necessitates the presence of new forms to decrease the risk of associated morbidity. Nanoparticles (NPs) are considered an important approach to selectively increase drug accumulation inside tumor cells and thus decreasing the associated side effects. Tumor cells develop resistance to chemotherapeutic agents through multiple mechanisms, one of which is over expression of efflux transporters...
September 16, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28930647/special-issue-on-liposomes-exosomes-and%C3%A2-virosomes
#19
EDITORIAL
Lukas K Tamm
No abstract text is available yet for this article.
September 19, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28929912/in%C3%A2-vivo-induction-of-neutrophil-extracellular-traps-by-mycobacterium-tuberculosis-in-a-guinea-pig-model
#20
Georgina Filio-Rodríguez, Iris Estrada-García, Patricia Arce-Paredes, María M Moreno-Altamirano, Sergio Islas-Trujillo, M Dolores Ponce-Regalado, Oscar Rojas-Espinosa
In 2004, a novel mechanism of cellular death, called 'NETosis', was described in neutrophils. This mechanism, different from necrosis and apoptosis, is characterized by the release of chromatin webs admixed with microbicidal granular proteins and peptides (NETs). NETs trap and kill a variety of microorganisms. Diverse microorganisms, including Mycobacterium tuberculosis, are NET inducers in vitro. The aim of this study was to examine whether M. tuberculosis can also induce NETs in vivo and if the NETs are bactericidal to the microorganism...
January 1, 2017: Innate Immunity
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