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https://www.readbyqxmd.com/read/29908286/il-6-deficiency-alters-spatial-memory-in-4-and-24-month-old-mice
#1
Izabela Bialuk, Andrzej Taranta, Maria Małgorzata Winnicka
Significance of interleukin 6 (IL-6) deficiency in cognitive processes was evaluated in 4- and 24-month-old C57BL/6J IL-6-deficient (IL-6 KO) and control (WT) mice in Morris water maze (MWM), holeboard test (HB) and elevated plus maze (EPM). During 3-day learning escape latency time (ELT) was longer in IL-6 KO than in WT mice, however their swimming was slower, floating longer, and path length did not differ. The comparison of ELT and the distance traveled between the first and the third learning day within each group revealed significant decrease of ELT in all groups with the highest difference in 4-month-old WT mice, and significant decrease of distance travelled only in both groups of WT mice...
June 13, 2018: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/29906478/does-nicotine-impact-tramadol-abuse-insights-from-neurochemical-and-neurobehavioral-changes-in-mice
#2
Shimaa M Azmy, Mai A Abd El Fattah, Sahar S Abd El-Rahman, Somia A Nada, Omar M E Abdel Salam, Mohammed F El-Yamany, Noha N Nassar
Nicotine and tramadol concomitant drug dependence pose increasing social, economic as well as public threats. Accordingly, the present study investigated neurochemical, neurobehavioral and neuropathological changes in the brain subsequent to the interaction of nicotine and tramadol. To this end, tramadol (20 mg/kg, i.p) and nicotine (0.25 mg/kg, i.p) were administrated to male albino mice once daily for 30 days. Consequent to microglial activation, nicotine exacerbated oxidative/nitrosative stress induced by tramadol as manifest by the step-up in thiobarbituric acid reactive substances and nitric oxide subsequent to the enhanced levels of neuronal and inducible nitric oxide synthases; paralleled by decreased non-protein sulfhydryls...
June 12, 2018: Neurotoxicology
https://www.readbyqxmd.com/read/29905055/-effect-of-chitosan-porous-scaffolds-combined-with-bone-marrow-mesenchymal-stem-cells-in-repair-of-neurological-deficit-after-traumatic-brain-injury-in-rats
#3
Keke Tan, Xiuxiu Wang, Jun Zhang, Zhigang Zhuang, Tieli Dong
Objective: To investigate the possibility and effect of chitosan porous scaffolds combined with bone marrow mesenchymal stem cells (BMSCs) in repair of neurological deficit after traumatic brain injury (TBI) in rats. Methods: BMSCs were isolated, cultured, and passaged by the method of bone marrow adherent culture. The 3rd generation BMSCs were identified by the CD29 and CD45 surface antigens and marked by 5-bromo-2-deoxyuridine (BrdU). The chitosan porous scaffolds were produced by the method of freeze-drying...
June 1, 2018: Chinese Journal of Reparative and Reconstructive Surgery
https://www.readbyqxmd.com/read/29901198/association-between-age%C3%A2-related-hearing-loss-and-cognitive-decline-in-c57bl-6j-mice
#4
Yang Dong, Chun-Rong Guo, Dan Chen, Sheng-Min Chen, Yinting Peng, Haiyan Song, Jian-Rong Shi
Accumulating evidence has revealed the link between age‑related hearing loss (presbycusis) and cognitive decline; however, their exact association remains unclear. The present study aimed to investigate the association between age‑related hearing loss and cognitive decline, and to explore the underlying mechanisms. Briefly, three groups of C57BL/6J mice were evaluated, based on their age, as follows: Young group, 3 months; adult group, 6 months; and middle‑aged group, 15 months. The results of an auditory brainstem response (ABR) test demonstrated that the hearing threshold levels of the mice were increased in those aged 6 and 15 months compared with those aged 3 months, thus suggesting that significant hearing loss occurred at 6 months, and worsened at 15 months...
June 1, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29896716/animal-tests-for-evaluation-of-cognitive-impairment-in-neonatal-mouse
#5
Ahmad Salimi, Jalal Pourahmad
For a long time, mice have been less popular than rats for studying cognitive impairment, mainly because much less neuroanatomical and neurochemical information was available on mice than on rats. Over the recent years, the generation of many types of transgenic mice has brought mice to the forefront of this research. Genetically modified mouse models have demonstrated useful to search memory and learning processes and the neurocircuitry and molecular mechanisms involved, as well as to extend therapies for cognitive impairment...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29896434/splenectomy-fails-to-provide-long-term-protection-against-ischemic-stroke
#6
Yuanyuan Ran, Zongjian Liu, Shuo Huang, Jiamei Shen, Fengwu Li, Wenxiu Zhang, Chen Chen, Xiaokun Geng, Zhili Ji, Huishan Du, Xiaoming Hu
Splenectomy before or immediately after stroke provides early brain protection. This study aims to explore the effect of splenectomy on long-term neurological recovery after stroke, which is currently lacking in the field. Adult male rats were randomized into splenectomy or sham groups and then subjected to 90 min of middle cerebral artery occlusion (MCAO). Spleen was removed right upon reperfusion or 3d after MCAO. Infarct volume, neurological functions, and peripheral immune cell populations were assessed up to 28d after stroke...
June 2018: Aging and Disease
https://www.readbyqxmd.com/read/29896066/streptozotocin-induced-diabetes-mellitus-affects-the-nmda-receptors-role-of-caffeine-administration-in-enhancing-learning-memory-and-locomotor-deficits
#7
Reem Al Marshad, Razan Al Khatib, Hanine Amer, Munirah Al Shammari, Aysha Al Otaibi, Fahad Al Otaibi, Nadiah Behbehani, Anwaar Al Sayed, Norah Al Hoty, Zuheir Hassan, Amer Kamal
Objective: To investigate the deterioration of the brain functions by diabetes mellitus (DM) and the beneficial effect of caffeine. Materials and Methods: First, the component of N-methyl-D-aspartate receptors (NMDA) of the field excitatory postsynaptic potential (fEPSP) were recorded in streptozotocin (STZ)-induced DM and compared with control animals. Later, 40 mice were divided randomly into five groups (8 mice in each): (1) Normal control (Cont), (2) diabetic group (DM), (3) animals pretreated with i...
May 2018: International Journal of Health Sciences
https://www.readbyqxmd.com/read/29894819/thalamic-proteome-changes-and-behavioral-impairments-in-thiamine-deficient-rats
#8
Polliana Toledo Nunes, Diana Paola Gómez-Mendoza, Cristiana Perdigão Rezende, Henrique César Pereira Figueiredo, Angela Maria Ribeiro
Thiamine deficiency (TD) has been used as an experimental model in rodents to study the molecular mechanisms of neurodegeneration and its association with behavioral changes. The aims of the present study were to investigate the spatial cognitive performance of pyrithiamine-induced thiamine deficiency (PTD) in adult male rats and disclose the thalamic proteome alterations caused by a severe TD episode. After the onset of the neurological signs, such as seizure and/or loss of righting reflex, the TD treatment was interrupted...
June 9, 2018: Neuroscience
https://www.readbyqxmd.com/read/29890032/chronic-administration-of-piperine-attenuates-behavioural-biochemical-and-histological-alterations-induced-by-intracerebroventricular-streptozotocin-in-rats
#9
M Nazifi, S Oryan, D Eslimi Esfahani, A A Moghadamnia, M Ashrafpour
Oxidative stress has been implicated in the pathogenesis of Alzheimer's disease (AD). Piperine is the major bio-active component of pepper. The aim of this study was to determine potential effects of chronic treatment with piperine on underlying biochemical, histological and behavioral changes following intracerebroventricular streptozotocin injection. Adult male Wistar rats, weighing 200-220g, were randomly assigned into 9 groups. In order to provide an animal model of the AD, streptozotocin (STZ) was bilaterally injected (3 mg/kg) into the lateral ventricles (ICV) twice on days 1 and 3...
June 11, 2018: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29889072/tocotrienol-rich-fraction-of-palm-oil-improves-behavioral-impairments-and-regulates-metabolic-pathways-in-a%C3%AE-pp-ps1-mice
#10
Lina Wati Durani, Hamizah Shahirah Hamezah, Nor Faeizah Ibrahim, Daijiro Yanagisawa, Muhammad Luqman Nasaruddin, Masaki Mori, Kamalrul Azlan Azizan, Hanafi Ahmad Damanhuri, Suzana Makpol, Wan Zurinah Wan Ngah, Ikuo Tooyama
We have recently shown that the tocotrienol-rich fraction (TRF) of palm oil, a mixture of vitamin E analogs, improves amyloid pathology in vitro and in vivo. However, precise mechanisms remain unknown. In this study, we examined the effects of long-term (10 months) TRF treatment on behavioral impairments and brain metabolites in (15 months old) AβPP/PS1 double transgenic (Tg) Alzheimer's disease (AD) mice. The open field test, Morris water maze, and novel object recognition tasks revealed improved exploratory activity, spatial learning, and recognition memory, respectively, in TRF-treated Tg mice...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29888573/-kidney-reinforcing-and-governor-vessel-regulating-ea-intervention-may-improve-learningmemory-possibly-by-suppressing-formation-of-senile-plaques-in-hippocampus-in-app-ps-1-double-transgenic-alzheimer-s-disease-mice
#11
Qing-Hua Yang, Ling Guo, Qing Chen, Kai-Hui Wu, Yan-Jun Wu, Yan Jia, Shu-Juan Zhu, Cheng-Lin Tang, Hua-Jun Sheng
OBJECTIVE: To observe the effect of electroacupuncture (EA) intervention on learning-memory ability and the expression of senile plaques (SP), amyloid precursor protein (APP), β-secretase 1(BACE 1) and insulin degrading enzyme (IDE) in the hippocampus in APP/presenilin 1 (PS 1) double transgenic Alzheimer's disease (AD) mice, so as to reveal its mechanisms underlying improvement of AD. METHODS: A total of 18 male APP/PS 1 double transgenic AD mice were randomly divided into model, EA-2-week and EA-3-week groups ( n =6 in each)...
April 25, 2018: Zhen Ci Yan Jiu, Acupuncture Research
https://www.readbyqxmd.com/read/29886761/paeonol-attenuates-isoflurane-anaesthesia-induced-hippocampal-neurotoxicity-via-modulation-of-jnk-erk-p38mapk-pathway-and-regulates-histone-acetylation-in-neonatal-rat
#12
Haiyan Jin, Minyan Wang, Jiangmei Wang, Hongmin Cao, Wanting Niu, Lizhong Du
OBJECTIVE: Volatile anaesthetic such as isoflurane causes widespread neurodegeneration in the developing animal brains and also induces cognitive impairments. Paeonol, is a plant-derived phenolic compound possessing numerous bioactive properties. The study investigates the neuroprotective effects of paeonol against isoflurane-induced neurodegeneration and cognitive disturbances in neonatal rats. METHODS: Paeonol (50, 100 and 150 mg/kg body weight/ day) was given orally to separate groups of neonatal rats from postnatal day 3 (P3) to P21 and were exposed to isoflurane (0...
June 10, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29886506/ginsenoside-ameliorates-cognitive-dysfunction-in-type-2-diabetic-goto-kakizaki-rats
#13
Zhiyan Tian, Ning Ren, Jinghua Wang, Danhong Zhang, Yuying Zhou
BACKGROUND Ginsenoside is the major bioactive component of ginseng, which has been proven to be a neuroprotective drug. The aim of this study was to evaluate the therapeutic effect of ginsenoside in a diabetic Goto-Kakizaki (GK) rat model. MATERIAL AND METHODS Twenty GK rats were randomly divided into a diabetic model (DM) group (n=10) and a ginsenoside + DM group (n=10); Wistar rats with the same age and body weight were used as the control (CON) group (n=10). Food and water intake, body weight, and blood fasting plasma glucose were measured...
June 10, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29886460/-impairment-of-spatial-learning-and-memory-and-changes-of-oxidative-stress-in-hippocampus-from-type-1-diabetic-mice
#14
Chun Wang, Gaoyou Lü, Yan Li, Shidi Zhao, Li Huang
To investigate the relevance between spatial learning and memory impairment and the changes of inducible nitric oxide synthase (iNOS) activity, superoxide dismutase (SOD) activity and malondiadehyde (MDA) content in hippocampus from Type 1 diabetic mice.
 Methods: Sixty male mice were randomly assigned into a control group (NC group, 20 mice) and a Type 1 diabetic group (DM group, 40 mice). Type 1 diabetic mouse models were established by a large dose intraperitoneal injection of streptozotocin (100 mg/kg)...
May 28, 2018: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/29885447/electroacupuncture-prevents-cognitive-impairment-induced-by-lipopolysaccharide-via-inhibition-of-oxidative-stress-and-neuroinflammation
#15
Yao-Guo Han, Xiong Qin, Tao Zhang, Ming Lei, Fang-Yuan Sun, Jing-Jing Sun, Wei-Fang Yuan
Oxidative stress and neuroinflammation play an important role in the pathophysiology of lipopolysaccharide (LPS)-induced cognitive impairment. This study aims to observe the effect of electroacupuncture (EA) on the cognitive function in LPS-induced mice, and its regulation on hippocampal α7 nicotinic acetylcholine receptors (α7nAChR), oxidative and proinflammatory factors. Adult male C57BL/6 nice were used to establish animal model of LPS-induced cognitive impairment, and were randomly divided into three groups (n = 16): control group, model group (LPS: 5 mg/kg), and EA group...
June 6, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29883380/pharmacological-basis-for-the-use-of-evodiamine-in-alzheimer-s-disease-antioxidation-and-antiapoptosis
#16
Yongfeng Zhang, Jiaqi Wang, Chunyue Wang, Zhiping Li, Xin Liu, Jun Zhang, Jiahui Lu, Di Wang
Evodiamine (Evo), a major alkaloid compound isolated from the dry unripened fruit of Evodia fructus, has a wide range of pharmacological activities. The present study sought to explore the neuroprotective effects of Evo in l-glutamate (l-Glu)-induced apoptosis of HT22 cells, and in a d-galactose and aluminum trichloride-developed Alzheimer’s disease (AD) mouse model. Evo significantly enhanced cell viability, inhibited the accumulation of reactive oxygen species, ameliorated mitochondrial function, increased the B-cell lymphoma-2 protein content, and inhibited the high expression levels of Bax, Bad, and cleaved-caspase-3 and -8 in l-Glu-induced HT22 cells...
May 21, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29883228/effectiveness-of-low-dose-of-rapamycin-in-preventing-seizure-induced-anxiety-like-behavior-cognitive-impairment-and-defects-in-neurogenesis-in-developing-rats
#17
Furong Liu, Meiling Wu, Jiejing Kai, Jingyin Dong, Binbin Zhang, Luna Liu, Feng Zhu, Ling-Hui Zeng
Previous studies have demonstrated that rapamycin prevents seizure-induced anxiety-like behaviors. However, rapamycin had been used at a higher dose of 3mg/kg and resulted in side effects in immature animals. The present work was designed to explore whether a lower dose of rapamycin has similar efficacy but has milder side effects. Acute seizures were induced by injection of pilocarpine at postnatal 10 day Sprague-Dawley rats. Western blot analysis was used to detect changes in mTOR pathway after seizure...
June 8, 2018: International Journal of Neuroscience
https://www.readbyqxmd.com/read/29881961/duration-dependent-effect-of-exposure-to-static-electric-field-on-learning-and-memory-ability-in-mice
#18
Yaqian Xu, Xiaoyu Gu, Guoqing Di
With the rapid development of ultra-high-voltage direct-current (UHVDC) transmission, the strength of environmental static electric field (SEF) around UHVDC transmission lines increased substantially, which has aroused widely public attention on the potential health effects of SEF. In this study, the effect of SEF exposure on learning and memory ability was investigated. Institute of Cancer Research mice were exposed to 56.3 kV/m SEF for a short term (7 days) or long term (49 days). Behaviors in the Morris water maze (MWM) test, hippocampal neurotransmitter contents, and oxidative stress indicators were examined...
June 7, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29881418/pre-treatment-with-erythropoietin-attenuates-bilateral-renal-ischemia-induced-cognitive-impairments
#19
Mahshid Tahamtan, Vahid Sheibani, Seyed Mostafa Shid Moosavi, Majid Asadi-Shekaari, Saeed Esmaeili-Mahani, Iraj Aghaei, Mohammad Shabani
One of the most common causes of mortality in acute kidney injury is brain dysfunction. Here we investigated the possible protective effect of erythropoietin (EPO) on cognitive impairments induced by bilateral renal ischemia (BRI). Eighty male Wistar rats were allocated into 8 groups: 1, 2) Sham +V (Vehicle), 3, 4) Sham+EPO, 5, 6) BRI+V, 7, 8) BRI+EPO. The groups followed by the reperfusion periods of 24hours (24 h) and 1week (1w). EPO or saline was administrated 30 min before surgery (1000 IU/kg, i.p). The cognitive function was assessed by passive avoidance learning and Morris water maze tests...
2018: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/29877067/effects-of-mesenchymal-stem-cells-transplantation-on-cognitive-deficits-in-animal-models-of-alzheimer-s-disease-a-systematic-review-and-meta-analysis
#20
REVIEW
Meiling Ge, Yunxia Zhang, Qiukui Hao, Yunli Zhao, Birong Dong
BACKGROUND: Alzheimer's disease (AD) is a globally prevalent neurodegenerative disease, clinically characterized by progressive memory loss and gradual impairment of cognitive functions. Mesenchymal stem cells (MSCs) transplantation has been considered a possible therapeutic method for Alzheimer's disease (AD). However, no quantitative data synthesis of MSC therapy for AD exists. We conducted a systematic review and meta-analysis to study the effects of MSCs on cognitive deficits in animal models of AD...
June 6, 2018: Brain and Behavior
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