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https://www.readbyqxmd.com/read/29457601/influences-of-combined-traffic-noise-on-the-ability-of-learning-and-memory-in-mice
#1
Guo-Qing Di, Zhao-Qi Qin
Objective: The present study aimed to evaluate the influences of combined traffic noise (CTN) on the ability of learning and memory in mice. Materials and Methods: The Institute of Cancer Research (ICR) mice were exposed to CTN from highways and high-speed railways for 42 days, whose day-night equivalent continuous A-weighted sound pressure level (Ldn ) was 70 dB(A). On the basis of behavioral reactions in Morris water maze (MWM) and the concentrations of amino acid neurotransmitters in the hippocampus, the impacts of CTN on learning and memory in mice were examined...
January 2018: Noise & Health
https://www.readbyqxmd.com/read/29456827/impairment-of-social-behaviors-in-arhgef10-knockout-mice
#2
Dai-Hua Lu, Hsiao-Mei Liao, Chia-Hsiang Chen, Huang-Ju Tu, Houng-Chi Liou, Susan Shur-Fen Gau, Wen-Mei Fu
Background: Impaired social interaction is one of the essential features of autism spectrum disorder (ASD). Our previous copy number variation (CNV) study discovered a novel deleted region associated with ASD. One of the genes included in the deleted region is ARHGEF10 . A missense mutation of ARHGEF10 has been reported to be one of the contributing factors in several diseases of the central nervous system. However, the relationship between the loss of ARHGEF10 and the clinical symptoms of ASD is unclear...
2018: Molecular Autism
https://www.readbyqxmd.com/read/29456645/influence-of-exposure-to-nicotine-during-pregnancy-on-the-learning-and-memory-for-adult-offspring
#3
Xing-Dui Ma, Bei-Ping Li, Yuan Han, Yun-Ping Tian, Liang Wu, Hang Wang
We aimed to investigate the indirect influence of exposure to nicotine during pregnancy on the learning and memory of adult offspring mice. Thirty pregnant C57 mice were randomly divided into either the control group (CON) or the nicotine group (NIC), with 15 mice each. The CON group was given access to drug-free water, and the NIC group was given 60 g/ml nicotine in drinking water. Sixteen adult mice were randomly selected from the 8 litters for Morris water maze test. The level of products of related factors in the hippocampus of mice in the NIC and the CON groups were compared using the1 H-MRS method...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29455541/the-efficacy-of-ozone-therapy-in-neonatal-rats-with-hypoxic-ischemic-brain-injury
#4
B Resitoglu, Y Celik, M Komur, A Polat, S Erdogan, A E Arslankoylu, H Beydagi
OBJECTIVES: This study is aimed to determine the effect of ozone therapy in neonatal rats with experimentally induced hypoxic ischemic brain injury (HIBI). METHODS: The study included 7-d-old male Wistar rats that were randomized to the sham, control, ozone 1, and ozone 2 groups. All rats except those in the sham group were kept in a hypoxia chamber, and then the rats in the control group were given 0.5 mL of saline. Those in the ozone 1 group were given ozone 1 mg kg-1 intraperitoneally, and those in the ozone 2 group were given ozone 2 mg kg-1 intraperitoneally...
2018: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/29454265/supplementation-of-lycopene-attenuates-lipopolysaccharide-induced-amyloidogenesis-and-cognitive-impairments-via-mediating-neuroinflammation-and-oxidative-stress
#5
Jia Wang, Lixia Li, Zhuo Wang, Yifan Cui, Xintong Tan, Tian Yuan, Qian Liu, Zhigang Liu, Xuebo Liu
Neuroinflammation is documented to be the major culprit of Alzheimer's disease. Lycopene (LYC), a fat soluble carotenoid, exhibits neuroprotective function in several neurodegenerative disorders. However, the effects of LYC to countering systemic inflammation-induced amyloidogenesis and memory deficiency remain to be elucidated. In current study, 3-month-old male C57BL/6J mice were treated with 0.03% LYC (w/w, mixed into normal chow) for 5 weeks. The mice were then treated by intraperitoneal injection of LPS (0...
February 2, 2018: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29453958/age-dependent-effects-of-dimethyl-fumarate-on-cognitive-and-neuropathological-features-in-the-streptozotocin-induced-rat-model-of-alzheimer-s-disease
#6
Irena Majkutewicz, Ewelina Kurowska, Magdalena Podlacha, Dorota Myślińska, Beata Grembecka, Jan Ruciński, Karolina Pierzynowska, Danuta Wrona
We previously demonstrated that dimethyl fumarate (DMF), an anti-oxidative and immunosuppresive compound, prevents intracerebroventricular (ICV) streptozotocin-induced disruption of spatial memory and neurodegeneration in 4-month-old rats. The present study evaluated the influence of age on DMF's therapeutic effect. Aged rats (22-months-old, n=40) were provided rodent chow containing DMF (0.4%) and given ICV injections of streptozotocin (STZ) or vehicle (Sham) on days 2 and 4. Spatial memory was evaluated using the Morris water maze (MWM) on days 14-21...
February 14, 2018: Brain Research
https://www.readbyqxmd.com/read/29452811/effects-on-adult-cognitive-function-after-neonatal-exposure-to-clinically-relevant-doses-of-ionising-radiation-and-ketamine-in-mice
#7
S Buratovic, B Stenerlöw, S Sundell-Bergman, A Fredriksson, H Viberg, T Gordh, P Eriksson
BACKGROUND: Radiological methods for screening, diagnostics and therapy are frequently used in healthcare. In infants and children, anaesthesia/sedation is often used in these situations to relieve the patients' perception of stress or pain. Both ionising radiation (IR) and ketamine have been shown to induce developmental neurotoxic effects and this study aimed to identify the combined effects of these in a murine model. METHODS: Male mice were exposed to a single dose of ketamine (7...
March 2018: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29449568/binge-alcohol-exposure-causes-neurobehavioral-deficits-and-gsk3%C3%AE-activation-in-the-hippocampus-of-adolescent-rats
#8
Zhe Ji, Lin Yuan, Xiong Lu, Hanqing Ding, Jia Luo, Zun-Ji Ke
Heavy alcohol exposure causes profound damage to the adolescent brain, particularly the hippocampus, which underlie some behavioral deficits. However, the underlying molecular mechanisms remain inconclusive. The current study sought to determine whether binge alcohol exposure affects the hippocampus-related behaviors and key signaling proteins that may mediate alcohol neurotoxicity in adolescent rats. Alcohol exposure reduced the number of both NeuN-positive and doublecortin-positive cells in the hippocampus...
February 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29447954/the-inhibitory-effect-of-levo-tetrahydropalmatine-on-the-methamphetamine-induced-spatial-memory-impairment-in-mice
#9
Guofen Cao, Yongai Zhang, Li Zhu, Jie Zhu, Na Zhao, Nan Dong, Yonghui Dang, Yanjiong Chen, Teng Chen
Methamphetamine (METH) administration results in addiction and memory impairment. Previous studies have suggested that levo-tetrahydropalmatine (l-THP), an alkaloid purified from the Chinese herb Corydalis, attenuates the behavioral changes induced by METH. Therefore, in this study, we explored whether l-THP could also protect against the METH-induced memory impairment examined using the Morris water maze (MWM). We found that low dose of METH (1.0 mg/kg) treated for 20 consecutive days prior to the MWM experiment impaired spatial memory retention but not acquisition in mice...
February 12, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29447949/protective-effects-of-alpinae-oxyphyllae-fructus-extracts-on-lipopolysaccharide-induced-animal-model-of-alzheimer-s-disease
#10
Yunlong Wang, Mengshi Wang, Kaiyue Fan, Tongde Li, Tingxu Yan, Bo Wu, Kaishun Bi, Ying Jia
ETHNOPHARMACOLOGICAL RELEVANCE: Alpinae Oxyphyllae Fructus (AOF) with warming and tonifying the kidney and spleen, anti-salivation, anti-polyuria and anti-diarrhea functions is the dried ripe fruits of Alpinia oxyphylla Miq. (Zingiberaceae). As a traditional Chinese medicine, its application history is very long. AIMS OF THE STUDY: The purpose of our study is to investigate the effects of different solvent extracts from AOF on lipopolysaccharide (LPS)-induced animal model of Alzheimer's disease (AD) to elucidate the traditional medical theories with modern pharmacological methods and provide a reference for further clarifying its active components and mechanisms...
February 12, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29443022/detecting-behavioral-deficits-in-rats-after-traumatic-brain-injury
#11
Nicole Hausser, Kathia Johnson, Margaret A Parsley, Jutatip Guptarak, Heidi Spratt, Stacy L Sell
With the increasing incidence of traumatic brain injury (TBI) in both civilian and military populations, TBI is now considered a chronic disease; however, few studies have investigated the long-term effects of injury in rodent models of TBI. Shown here are behavioral measures that are well-established in TBI research for times early after injury, such as two weeks, until two months. Some of these methods have previously been used at later times after injury, up to one year, but by very few laboratories. The methods demonstrated here are a short neurological assessment to test reflexes, a Beam-Balance to test balance, a Beam-Walk to test balance and motor coordination, and a working memory version of the Morris water maze that can be sensitive to deficits in reference memory...
January 30, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29441990/the-autophagy-inhibitor-3-methyladenine-restores-sevoflurane-anesthesiainduced-cognitive-dysfunction-and-neurons-apoptosis
#12
Xiaoyu Xiao, Yingxian Zhu, Juyuan Bu, Guowei Li, Zibin Liang, Lukun Yang, Bingzong Hou
This study was designed to explore the effect of 3-methyladenine (3-MA) on sevoflurane anesthesia-induced cognitive dysfunction. A total of 60 C57BL/6 (5-8 months old) mice were randomly arranged into 3 groups: Control, sevoflurane (Sev) and Sev+3-MA group with 3-MA administration was performed during Sev administration. Morris water maze and Y-maze test were performed to examine the behavioral disorders. Moreover, hippocampal neuronal cell apoptosis and expression of autophagy related genes were detected. Sevoflurane induced cognitive dysfunction in mice showing significant longer escape latency, lower number of correct response, higher apoptotic neurons, and higher expression of autophagy related genes...
April 1, 2017: Die Pharmazie
https://www.readbyqxmd.com/read/29440657/nippostrongylus-brasiliensis-infection-leads-to-impaired-reference-memory-and-myeloid-cell-interference
#13
T M Brombacher, K S De Gouveia, L Cruywagen, N Makena, F Booley, O Tamgue, F Brombacher
Hookworm infection is endemic in developing countries, leading to poor cognitive function-among other disruptions. In this study, the effects of Nippostrongylus brasiliensis infection (a murine model of Necator Americanus) on cognitive function were investigated. Though impaired cognition has been extensively reported, the exact domain of cognition affected is still unknown, hence requiring investigation. The objective of this study was to identify possible cognitive changes during Nippostrongylus brasiliensis infection in mice, using the Morris water maze...
February 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29439655/high-fat-diet-aggravates-postoperative-cognitive-dysfunction-in-aged-mice
#14
Lan Wei, Minmin Yao, Zhimeng Zhao, Hui Jiang, Shengjin Ge
BACKGROUND: Silent Information Regulator 1 (Sirt1) and apoptosis play key roles in postoperative cognitive dysfunction (POCD). Consuming a high-fat diet (HFD), a prevalent type of diet in modern society, has been increasingly recognized as contributing to neurodegenerative diseases. Although Sirt1 and apoptosis are significant responders to HFD in the brain, little is known regarding the functional correlations between HFD and POCD. METHODS: Thirty-two aged C57BL/6 male mice were randomly divided into 2 groups: an ad libitum (AL) group (fed a regular diet) and high-fat diet (HF) group (fed a high-fat diet)...
February 13, 2018: BMC Anesthesiology
https://www.readbyqxmd.com/read/29436629/cognitive-improvement-following-ischemia-reperfusion-injury-induced-by-voluntary-running%C3%A2-wheel-exercise-is-associated-with-lncmalat1%C3%A2-mediated-apoptosis-inhibition
#15
Jin-Lin Shang, Qing Cheng, Sheng-Jie Duan, Lu Li, Li-Ya Jia
Previous human and animal studies demonstrated that voluntary exercise may improve cognitive function and facilitate neuronal plasticity in ischemia/reperfusion (I/R) models. However, the possible underlying mechanisms remain to be elucidated. Metastasis‑associated lung adenocarcinoma transcript 1 (MALAT1), a long noncoding RNA (lncRNA), may be associated with the functions and dysfunctions of endothelial cells. The present study investigated whether spontaneous running‑wheel (RW) exercise‑induced MALAT1 expression changes may be associated with the cognitive improvement of mice following I/R injury...
February 12, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29434250/dyrk1a-inhibition-and-cognitive-rescue-in-a-down-syndrome-mouse-model-are-induced-by-new-fluoro-dandy-derivatives
#16
Fernanda Neumann, Stéphanie Gourdain, Christelle Albac, Alain D Dekker, Linh Chi Bui, Julien Dairou, Isabelle Schmitz-Afonso, Nathalie Hue, Fernando Rodrigues-Lima, Jean M Delabar, Marie-Claude Potier, Jean-Pierre Le Caër, David Touboul, Benoît Delatour, Kevin Cariou, Robert H Dodd
Inhibition of DYRK1A kinase, produced by chromosome 21 and consequently overproduced in trisomy 21 subjects, has been suggested as a therapeutic approach to treating the cognitive deficiencies observed in Down syndrome (DS). We now report the synthesis and potent DYRK1A inhibitory activities of fluoro derivatives of 3,5-di(polyhydroxyaryl)-7-azaindoles (F-DANDYs). One of these compounds (3-(4-fluorophenyl)-5-(3,4-dihydroxyphenyl)-1H-pyrrolo[2,3-b]pyridine, 5a) was selected for in vivo studies of cognitive rescuing effects in a standard mouse model of DS (Ts65Dn line)...
February 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29434234/altered-aspects-of-anxiety-related-behavior-in-kisspeptin-receptor-deleted-male-mice
#17
Sarah Delmas, Robert Porteous, Dave H Bergin, Allan E Herbison
The roles of kisspeptin signaling outside the hypothalamus in the brain are unknown. We examined here the impact of Kiss1r-deletion on hippocampus-related behaviors of anxiety and spatial learning in adult male mice using two mouse models. In the first, global Kiss1r-null and control mice were gonadectomized (GDX KISS1R-KO). In the second, KISS1R signalling was rescued selectively in gonadotropin-releasing hormone neurons to generate Kiss1r-null mice with normal testosterone levels (intact KISS1R-KO). Intact KISS1R-KO rescue mice were found to spend twice as much time in the open arms of the elevated plus maze (EPM) compared to controls (P < 0...
February 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29433251/ethyl-acetate-fraction-from-hibiscus-sabdariffa-l-attenuates-diabetes-associated-cognitive-impairment-in-mice
#18
Tae Wan Seung, Seon Kyeong Park, Jin Yong Kang, Jong Min Kim, Sang Hyun Park, Bong Seok Kwon, Chang Jun Lee, Jeong Eun Kang, Dae Ok Kim, Uk Lee, Ho Jin Heo
The ameliorating effects of the ethyl acetate fraction from Hibiscus sabdariffa L. (EFHS) 2 against diabetes mellitus (DM) 3 and DM-induced cognitive impairment were investigated on streptozotocin (STZ) 4 -induced DM mice. The EFHS groups showed improved hyperglycemia and glucose tolerance compared to the STZ group. Furthermore, their liver and kidney function and lipid metabolic imbalance in the blood serum were effectively recovered. The EFHS groups significantly ameliorated STZ-induced cognitive impairment in Y-maze, passive avoidance, and Morris water maze (MWM) 5 tests...
March 2018: Food Research International
https://www.readbyqxmd.com/read/29430738/neonatal-adoptive-transfer-of-lymphocytes-rescues-social-behavior-during-adolescence-in-immune-deficient-mice
#19
Sarah M Clark, Chloe N Vaughn, Jennifer A Soroka, Xin Li, Leonardo H Tonelli
Accumulating evidence has shown that lymphocytes modulate behavior and cognition by direct interactions with the central nervous system. Studies have shown that reconstitution by adoptive transfer of lymphocytes from wild type into immune deficient mice restores a number of neurobehavioral deficits observed in these models. Moreover, it has been shown that these effects are mostly mediated by T lymphocytes. Studies of adoptive transfer thus far have employed adult mice, but whether lymphocytes may also modulate behavior during development remains unknown...
February 11, 2018: European Journal of Neuroscience
https://www.readbyqxmd.com/read/29428385/cognitive-enhancing-effect-of-polysaccharides-from-flammulina-velutipes-on-alzheimer-s-disease-by-compatibilizing-with-ginsenosides
#20
Yan Zhang, Hui Li, Xiudong Yang, Gang Jin, Yang Zhang
This study was performed to evaluate the cognitive-enhancing effect Flammulina velutipes polysaccharides (FVP) by compatibilizing with ginsenosides on D-galactose-induced Alzheimer's disease (AD) rats. Results of the Morris water maze test suggested that the cognitive ability of AD rats was significantly elevated after combined treatment with FVP and ginsenosides. Moreover, the anti-oxidant effect was also elevated as reflected by the increased levels of superoxide dismutase, catalase, and glutathione peroxidase and decreased levels of malondialdehyde in the combination group...
February 8, 2018: International Journal of Biological Macromolecules
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