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Ischemia and reperfusion injury

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https://www.readbyqxmd.com/read/29677548/combination-of-curcumin-and-vagus-nerve-stimulation-attenuates-cerebral-ischemia-reperfusion-injury-induced-behavioral-deficits
#1
Jian Xu, Xinjuan Kong, Hong Xiu, Yihe Dou, Zeyu Wu, Peng Sun
AIM: Previous studies indicated that cerebral ischemia/reperfusion injury (CI/RI) could induce behavioral deficits. Single treatment of vagus nerve stimulation (VNS) or curcumin is reported to restore CI/RI-induced behavioral deficits. However, the synergic effect remains unclear. MATERIALS AND METHODS: Rats were divided into 6 groups: sham, CI/RI, VNS, CI/RI + VNS, VNS + curcumin and CI/RI + VNS + curcumin groups. Each group was further divided into three or four subgroups for further assessments...
April 17, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29677080/corm-401-reduces-ischemia-reperfusion-injury-in-an-ex-vivo-renal-porcine-model-of-the-donation-after-cardiac-death
#2
Rabindra N Bhattacharjee, Mahms Richard-Mohamed, Qizhi Sun, Aaron Haig, Ghaleb Aboalsamh, Peter Barrett, Richard Mayer, Ibrahim Alhasan, Karen Pineda-Solis, Larry Jiang, Hajed Alharbi, Manujendra Saha, Eric Patterson, Alp Sener, Gediminas Cepinskas, Anthony M Jevnikar, Patrick P W Luke
BACKGROUND: Carbon monoxide (CO) inhalation protects organ by reducing inflammation and cell death during transplantation processes in animal model. However, using CO in clinical transplantation is difficult due to its delivery in a controlled manner. A manganese-containing CORM-401 has recently been synthesized which can efficiently deliver 3 molar equivalents of CO. We report the ability of this anti-inflammatory CORM-401 to reduce ischemia reperfusion injury associated with prolonged cold storage of renal allografts obtained from donation after cardiac death in a porcine model of transplantation...
April 19, 2018: Transplantation
https://www.readbyqxmd.com/read/29676955/mitochondrial-genome-modulates-myocardial-akt-glut-hk-salvage-pathway-in-spontaneously-hypertensive-rats-adapted-to-chronic-hypoxia
#3
Iveta Nedvedova, David Kolar, Barbara Elsnicova, Daniela Hornikova, Jiri Novotny, Martin Kalous, Michal Pravenec, Jan Neckar, Frantisek Kolar, Jitka M Zurmanova
Recently we have shown that adaptation to continuous normobaric hypoxia (CNH) decreases myocardial ischemia/reperfusion injury in spontaneously hypertensive rats (SHR) and in conplastic strain (SHR-mtBN ). The protective effect was stronger in the latter group characterized by a selective replacement of SHR mitochondrial genome with that of a more ischemia-resistant Brown Norway strain. The aim of the present study was to examine the possible involvement of the hypoxia inducible factor (HIF)-dependent pathway of the protein kinase B/glucose transporters/hexokinase (Akt/GLUT/HK) in this mitochondrial genome-related difference of the cardioprotective phenotype...
April 20, 2018: Physiological Genomics
https://www.readbyqxmd.com/read/29676103/-protective-effect-and-mechanism-of-p-hydroxybenzaldehyde-on-blood-brain-barrier
#4
Yan-Ping Zhu, Xin Li, Yao Du, Lu Zhang, Li Ran, Ning-Na Zhou
The disruption of blood-brain barrier(BBB) induced by oxidative stress is an important pathological reaction which results in secondary brain injury during the cerebral ischemia-reperfusion. This study was designed to investigate the protective effect and mechanism of p-hydroxybenzaldehyde (p-HBA) from Gastrodia elata on BBB. The BBB is mainly consisted of vascular endothelial cells and astrocytes, so brain microvascular endothelial cell line (bEnd.3) and astrocytes (Ast) in mice were used in this study to establish BBB model...
March 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29675132/honokiol-ameliorates-myocardial-ischemia-reperfusion-injury-in-type-1-diabetic-rats-by-reducing-oxidative-stress-and-apoptosis-through-activating-the-sirt1-nrf2-signaling-pathway
#5
Bin Zhang, Mengen Zhai, Buying Li, Zhenhua Liu, Kaifeng Li, Liqing Jiang, Meng Zhang, Wei Yi, Jian Yang, Dinghua Yi, Hongliang Liang, Zhenxiao Jin, Weixun Duan, Shiqiang Yu
Reducing oxidative stress is a crucial therapeutic strategy for ameliorating diabetic myocardial ischemia/reperfusion (MI/R) injury. Honokiol (HKL) acts as an effective cardioprotective agent for its strong antioxidative activity. However, its roles and underlying mechanisms against MI/R injury in type 1 diabetes (T1D) remain unknown. Since SIRT1 and Nrf2 are pivotal regulators in diabetes mellitus patients suffering from MI/R injury, we hypothesized that HKL ameliorates diabetic MI/R injury via the SIRT1-Nrf2 signaling pathway...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29674977/serum-derived-extracellular-vesicles-protect-against-acute-myocardial-infarction-by-regulating-mir-21-pdcd4-signaling-pathway
#6
Huanyu Gu, Zhuyuan Liu, Yongqin Li, Yuan Xie, Jianhua Yao, Yujiao Zhu, Jiahong Xu, Qiying Dai, Chongjun Zhong, Hao Zhu, Shengguang Ding, Lei Zhou
Acute myocardial infarction (AMI) represents a leading cause of morbidity and mortality worldwide. Extracellular vesicles (EVs) are being recognized as a promising therapeutic approach in protecting against MI. Serum is a rich source of EVs, which transports various microRNAs (miRNAs, miRs). EVs from serum have been shown beneficial for protecting against ischemia-reperfusion injury; however, their roles in AMI are unclear. In addition, whether a miRNA might be responsible for the effects of serum EVs on protecting against AMI is undetermined...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29674972/gualou-xiebai-decoction-a-traditional-chinese-medicine-prevents-cardiac-reperfusion-injury-of-hyperlipidemia-rat-via-energy-modulation
#7
Lu-Lu Yan, Wei-Yang Zhang, Xiao-Hong Wei, Li Yan, Chun-Shui Pan, Yang Yu, Jing-Yu Fan, Yu-Ying Liu, Hua Zhou, Jing-Yan Han, Xin-Sheng Yao
Background: Gualou Xiebai Decoction (GLXB) is a classic prescription of Chinese medicine used for the treatment of cardiac problems. The present study was designed to explore the effect and mechanism of GLXB on ischemia/reperfusion (I/R) induced disorders in myocardial structure and function, focusing on the regulation of energy metabolism and the RhoA/ROCK pathway. Methods: After hyperlipidemic rat model was established by oral administration of high fat diet, the rats were treated with GLXB for 6 weeks and subjected to 30 min occlusion of the left anterior descending coronary artery (LADCA) followed by 90 min reperfusion to elicit I/R challenge...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29674944/dunye-guanxinning-improves-acute-myocardial-ischemia-reperfusion-injury-by-inhibiting-neutrophil-infiltration-and-caspase-1-activity
#8
Q G Zhang, S R Wang, X M Chen, H N Guo, S Ling, J W Xu
Acute myocardial infarction is the most serious manifestation of cardiovascular disease, and it is a life-threatening condition. Dunye Guanxinning (DG) is a protective traditional Chinese patent herbal medicine with high clinical efficacy and suitable for the treatment of myocardial infarction. However, the mechanism through which it is beneficial is unclear. In this study, we hypothesized that DG improves acute myocardial ischemia-reperfusion injury by inhibiting neutrophil infiltration and caspase-1 activity...
2018: Mediators of Inflammation
https://www.readbyqxmd.com/read/29674665/the-proximal-tubular-%C3%AE-7-nicotinic-acetylcholine-receptor-attenuates-ischemic-acute-kidney-injury-through-akt-pkc-signaling-mediated-ho-1-induction
#9
Hwajin Kim, So Ra Kim, Jihyun Je, Kyuho Jeong, Sooji Kim, Hye Jung Kim, Ki Churl Chang, Sang Won Park
Activation of the α7 nicotinic acetylcholine receptor (α7nAChR) has been shown to attenuate excessive inflammation by inhibiting proinflammatory cytokines during ischemia-reperfusion (IR) injury; however, the underlying kidney-specific molecular mechanisms remain unclear. The protective action of α7nAChR against renal IR injury was investigated using a selective α7nAChR agonist and antagonist. α7nAChR activation reduced plasma creatinine levels and tubular cell damage, whereas α7nAChR inhibition aggravated the IR-induced phenotype...
April 20, 2018: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/29673933/lysophosphatidic-acid-induces-neuronal-cell-death-via-activation-of-asparagine-endopeptidase-in-cerebral-ischemia-reperfusion-injury
#10
Chao Wang, Jie Zhang, Junchun Tang, Yi-Yi Li, YanXia Gu, Ying Yu, Jing Xiong, Xueqing Zhao, Zheng Zhang, Ting-Ting Li, Jutao Chen, Qi Wan, Zhaohui Zhang
Lysophosphatidic acid (LPA), an extracellular signaling molecule, influences diverse biological events, including the pathophysiological process induced after ischemic brain injury. However, the molecular mechanisms mediating the pathological change after ischemic stroke remain elusive. Here we report that asparagine endopeptidase (AEP), a lysosomal cysteine proteinase, is regulated by LPA during stroke. AEP proteolytically cleaves tau and generates tauN368 fragments, triggering neuronal death. Inhibiting the generation of LPA reduces the expression of AEP and tauN368, and alleviates neuronal cell death...
April 16, 2018: Experimental Neurology
https://www.readbyqxmd.com/read/29672298/intermittent-hypoxia-inhibits-na-h-exchange-mediated-acid-extrusion-via-intracellular-na-accumulation-in-cardiomyocytes
#11
Huai-Ren Chang, Chih-Feng Lien, Jing-Ren Jeng, Jen-Che Hsieh, Chen-Wei Chang, Jian-Hong Lin, Kun-Ta Yang
BACKGROUND/AIMS: Intermittent hypoxia (IH) has been shown to exert preconditioning-like cardioprotective effects. It also has been reported that IH preserves intracellular pH (pHi) during ischemia and protects cardiomyocytes against ischemic reperfusion injury. However, the exact mechanism is still unclear. METHODS: In this study, we used proton indicator BCECF-AM to analyze the rate of pHi recovery from acidosis in the IH model of rat neonatal cardiomyocytes. Neonatal cardiomyocytes were first treated with repetitive hypoxia-normoxia cycles for 1-4 days...
April 16, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29671257/glycogen-synthase-kinase-3%C3%AE-opens-mitochondrial-permeability-transition-pore-through-mitochondrial-hexokinase-ii-dissociation
#12
Takamitsu Tanaka, Masao Saotome, Hideki Katoh, Terumori Satoh, Prottoy Hasan, Hayato Ohtani, Hiroshi Satoh, Hideharu Hayashi, Yuichiro Maekawa
Accumulating evidence has revealed pivotal roles of glycogen synthase kinase-3β (GSK3β) inactivation on cardiac protection. Because the precise mechanisms of cardiac protection against ischemia/reperfusion (I/R) injury by GSK3β-inactivation remain elusive, we investigated the relationship between GSK3β-mediated mitochondrial hexokinase II (mitoHK-II; a downstream target of GSK3β) dissociation and mitochondrial permeability transition pore (mPTP) opening. In Langendorff-perfused hearts, GSK3β inactivation by SB216763 improved the left ventricular-developed pressure and retained mitoHK-II binding after I/R...
April 18, 2018: Journal of Physiological Sciences: JPS
https://www.readbyqxmd.com/read/29671210/indian-ginseng-withania-somnifera-supplementation-ameliorates-oxidative-stress-and-mitochondrial-dysfunctions-in-experimental-model-of-stroke
#13
Abhilasha Sood, Arpit Mehrotra, Devinder K Dhawan, Rajat Sandhir
Stroke is an increasingly prevalent clinical condition and second leading cause of death globally. The present study evaluated the therapeutic potential of Indian Ginseng, also known as Withania somnifera (WS), supplementation on middle cerebral artery occlusion (MCAO) induced mitochondrial dysfunctions in experimental model of ischemic stroke. Stroke was induced in animals by occluding the middle cerebral artery, followed by reperfusion injury. Ischemia reperfusion injury resulted in increased oxidative stress indicated by increased reactive oxygen species and protein carbonyl levels; compromised antioxidant system; in terms of reduced superoxide dismutase and catalase activity, along with reduction in GSH levels and the redox ratio, impaired mitochondrial functions and enhanced expression of apoptosis markers...
April 18, 2018: Metabolic Brain Disease
https://www.readbyqxmd.com/read/29671020/luteolin-alleviates-cardiac-ischemia-reperfusion-injury-in-the-hypercholesterolemic-rat-via-activating-akt-nrf2-signaling
#14
Jin-Ting Yang, Jue Wang, Xin-Ru Zhou, Chi Xiao, Yang-Yun Lou, Li-Hui Tang, Feng-Jiang Zhang, Ling-Bo Qian
Myocardial ischemia/reperfusion (I/R) injury in hypercholesterolemia is associated with oxidative stress, while luteolin is known to reduce oxidative stress by activating Akt/nuclear factor erythroid-2-related factor 2 (Nrf2) signaling and alleviate cardiac I/R injury. Here, we investigated whether luteolin pretreatment diminishes myocardial I/R injury in hypercholesterolemic rats by activating Akt/Nrf2 signaling. Hypercholesterolemic rats were produced by 2% cholesterol diet for 8 weeks. Luteolin (100 mg/kg/day, i...
April 18, 2018: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/29671019/lixisenatide-a-novel-glp-1-analog-protects-against-cerebral-ischemia-reperfusion-injury-in-diabetic-rats
#15
Rania G Abdel-Latif, Gehan H Heeba, Ashraf Taye, Mohamed M A Khalifa
Type 2 diabetes mellitus (T2DM) is a major risk factor for ischemic stroke accompanied by vascular dysfunction and poor cerebrovascular outcome. Lixisenatide is a glucagon like peptide-1 (GLP-1) analog that is recently used for T2DM treatment with established neuroprotective properties. This study investigated and compared the neuroprotective effect of lixisenatide against glimepiride on diabetic rats subjected to global cerebral ischemia/reperfusion (I/R) injury. T2DM-induced adult male Wistar rats were administered lixisenatide or glimepiride prior to induction of global cerebral I/R-induced injury...
April 18, 2018: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/29670333/upregulation-of-vascular-endothelial-growth-factor-receptor-1-contributes-to-sevoflurane-preconditioning-mediated-cardioprotection
#16
Bin Qian, Yang Yang, Yusheng Yao, Yanling Liao, Ying Lin
Purpose: Sevoflurane preconditioning (SPC) can provide myocardial protective effects similar to ischemic preconditioning. However, the exact mechanism of SPC remains unclear. Previous studies indicate that vascular endothelial growth factor receptor 1 (VEGFR-1) is involved in ischemic preconditioning-mediated cardioprotection. This study was designed to determine the significance of VEGFR-1 signaling in SPC-mediated cardioprotection. Materials and methods: Myocardial ischemia-reperfusion (I/R) rat model was established using the Langendorff isolated heart perfusion apparatus...
2018: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29670247/effects-of-microrna-292-5p-on-myocardial-ischemia-reperfusion-injury-through-the-peroxisome-proliferator-activated-receptor-%C3%AE-%C3%AE-signaling-pathway
#17
Zhen-Dong Zhu, Ji-Yun Ye, Hua Niu, Yu-Mei Ma, Xue-Mei Fu, Zhong-Hua Xia, Xuan Zhang
Ischemia-reperfusion injury (IRI) is a major cause of cardiac damage following various pathological processes, such as free radical damage and cell apoptosis. This study aims to investigate whether microRNA-292-5p (miR-292-5p) protects against myocardial ischemia-reperfusion injury (IRI) via the peroxisome proliferator-activated receptor (PPAR)-α/-γ signaling pathway in myocardial IRI mice models. Mouse models of myocardial IRI were established. Adult male C57BL/6 mice were divided into different groups. The hemodynamic indexes, levels of related inflammatory factors and serum myocardial enzymes, and malondialdehyde (MDA) content and the activity of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) were detected...
April 18, 2018: Gene Therapy
https://www.readbyqxmd.com/read/29669712/er-chaperone-grp78-protects-heart-from-ischemia-reperfusion-injury-through-akt-activation
#18
Xukun Bi, Guangyu Zhang, Xiaoding Wang, Chau Yt Nguyen, Herman I May, Xiaoting Li, Ali Al-Hashimi, Richard C Austin, Thomas G Gillette, Guo Sheng Fu, Zhao V Wang, Joseph A Hill
<u>Rationale:</u> Restoration of coronary artery blood flow is the most effective means of ameliorating myocardial damage triggered by ischemic heart disease. However, coronary reperfusion elicits an increment of additional injury to the myocardium. Accumulating evidence indicates that the unfolded protein response (UPR) in cardiomyocytes is activated by ischemia/reperfusion (I/R) injury. Xbp1s, the most highly conserved branch of the UPR, is protective in response to cardiac I/R injury. GRP78, a master regulator of the UPR and an Xbp1s target, is up-regulated after I/R...
April 18, 2018: Circulation Research
https://www.readbyqxmd.com/read/29668781/the-effect-of-metyrosine-on-oxidative-gastric-damage-induced-by-ischemia-reperfusion-in-rats-biochemical-and-histopathological-evaluation
#19
Orhan Çimen, Ferda Keskin Çimen, Mine Gülapoğlu, Aslı Özbek Bilgin, Arif Burak Çekiç, Hüseyin Eken, Zeynep Süleyman, Yasin Bilgin, Durdu Altuner
PURPOSE: To investigate the effect of metyrosine against I/R induced gastric damage in rats. METHODS: Eighteen albino Wistar male rats were divided into groups; gastric I/R (GIR), 50 mg/kg metyrosine+gastric I/R (MGIR), and sham (SG) groups. 50 mg/kg metyrosine was given to the MGIR group, and distilled water was given to the GIR and SG groups by the oral gavage. After 30 minutes, 25 mg/kg thiopental sodium was injected intraperitoneally. Ischemia was achieved for 1 hour by clamping the celiac artery of the MGIR and GIR groups, then reperfusion was achieved for 3 hours...
March 2018: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/29668777/combined-effects-of-melatonin-and-topical-hypothermia-on-renal-ischemia-reperfusion-injury-in-rats
#20
Pablo Cambeses Souza, Emanuel Burck Dos Santos, Guilherme Lang Motta, Silvia Regina Bona, Pedro Guilherme Schaefer, Daniela Campagnol, Tiago Bortolini, Carlos Otávio Corso
PURPOSE: To evaluate whether their combination was more effective than either alone in decreasing renal damage due to ischemia/reperfusion (I/R) injury in rats. METHODS: Thirty-two Wistar rats were assigned to four groups. Following right nephrectomy, their left kidneys were subjected to warm ischemia (IR), cold ischemia (TH+IR), intraperitoneal injection of 10 mg/kg melatonin (MEL+IR), or injection of 10 mg/kg melatonin followed by cold ischemia (MEL+TH+IR). Eight randomly assigned right kidneys constituted the control group...
March 2018: Acta Cirúrgica Brasileira
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