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https://www.readbyqxmd.com/read/28650355/axillary-dissection-and-nodal-irradiation-can-be-avoided-for-most-node-positive-z0011-eligible-breast-cancers-a-prospective-validation-study-of-793-patients
#1
Monica Morrow, Kimberly J Van Zee, Sujata Patil, Oriana Petruolo, Anita Mamtani, Andrea V Barrio, Deborah Capko, Mahmoud El-Tamer, Mary L Gemignani, Alexandra S Heerdt, Laurie Kirstein, Melissa Pilewskie, George Plitas, Virgilio S Sacchini, Lisa M Sclafani, Alice Ho, Hiram S Cody
OBJECTIVE: To determine rates of axillary dissection (ALND) and nodal recurrence in patients eligible for ACOSOG Z0011. BACKGROUND: Z0011 demonstrated that patients with cT1-2N0 breast cancers and 1 to 2 involved sentinel lymph nodes (SLNs) having breast-conserving therapy had no difference in locoregional recurrence or survival after SLN biopsy alone or ALND. The generalizability of the results and importance of nodal radiotherapy (RT) is unclear. METHODS: Patients eligible for Z0011 had SLN biopsy alone...
July 22, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28640447/role-of-serca-pump-in-muscle-thermogenesis-and-metabolism
#2
Muthu Periasamy, Santosh Kumar Maurya, Sanjaya Kumar Sahoo, Sushant Singh, Sanjaya Kumar Sahoo, Felipe C G Reis, Naresh Chandra Bal
In muscle cells, the sarcoplasmic reticulum (SR) not only acts as a Ca2+ store, but also regulates the contractile characteristics of the muscle. Ca2+ release from the SR is the primary mechanism for activating muscle contraction and reuptake of Ca2+ by the sarcoplasmic reticulum Ca2+ ATPase (SERCA) pump causes muscle relaxation. The SERCA pump isoforms are encoded by three genes, SERCA 1, 2, and 3, which are differentially expressed in muscle and determine SR Ca2+ dynamics by affecting the rate and amount of Ca2+ uptake, thereby affecting SR store and release of Ca2+ in muscle...
June 18, 2017: Comprehensive Physiology
https://www.readbyqxmd.com/read/28608612/factors-impacting-the-accuracy-of-intra-operative-evaluation-of-sentinel-lymph-nodes-in-breast-cancer
#3
Catherine L Akay, Constance Albarracin, Tiffany Torstenson, Roland Bassett, Elizabeth A Mittendorf, Min Yi, Henry M Kuerer, Gildy V Babiera, Isabelle Bedrosian, Kelly K Hunt, Rosa F Hwang
Sentinel lymph node dissection (SLND) is a standard axillary staging technique in breast cancer and intraoperative sentinel lymph node (SLN) assessment is important for decision-making regarding additional treatment and reconstruction. This study was undertaken to investigate clinicopathologic factors impacting the accuracy of intraoperative SLN evaluation. Records of patients with clinically node-negative, invasive breast cancer who underwent SLND with frozen section intraoperative pathologic evaluation from 2004 to 2007 were reviewed...
June 13, 2017: Breast Journal
https://www.readbyqxmd.com/read/28608117/can-we-define-the-risk-of-lymph-node-metastasis-in-early-stage-cervical-cancer-patients-a-large-scale-retrospective-study
#4
Gabriella Ferrandina, Luigi Pedone Anchora, Valerio Gallotta, Anna Fagotti, Enrico Vizza, Vito Chiantera, Pierandrea De Iaco, Alfredo Ercoli, Giacomo Corrado, Carolina Bottoni, Francesco Fanfani, Giovanni Scambia
BACKGROUND: Sentinel lymph node (SLN) biopsy has emerged as one of the most appreciated techniques for reducing the rate of complete lymph node dissection (LND) performed in patients with early-stage cervical cancer (ECC). However, its performances are still a matter of debate and, to improve them, international guidelines recommend performing at least unilateral LND in case of SLN mapping. In a prior study, we identified a group of patients without evidence of lymph node metastasis (LNM)...
June 12, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28604450/low-volume-lymph-node-metastases-in-endometrial-carcinoma
#5
Lani K Clinton, Jordan Kondo, Michael E Carney, Pamela Tauchi-Nishi, Keith Terada, David Shimizu
OBJECTIVE: The aim of this study was to determine the histopathologic characteristics of patients with endometrial carcinoma with low-volume metastases (micrometastases and isolated tumor cells) compared with macrometastases. METHODS: We performed a retrospective review of patients with endometrial carcinoma. RESULTS: Among 350 robotic-assisted hysterectomies for endometrial cancer, 187 (53%) underwent attempted sentinel lymph node (SLN) biopsy...
June 10, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28599884/comparing-single-site-and-multiport-robotic-hysterectomy-with-sentinel-lymph-node-mapping-for-endometrial-cancer-surgical-outcomes-and-cost-analysis
#6
Lea A Moukarzel, Abdulrahman K Sinno, Amanda N Fader, Edward J Tanner
STUDY OBJECTIVE: To compare operative times, surgical outcomes, and costs of robotic laparo-endoscopic single-site (R-LESS) versus multiport robotic (MPR) total laparoscopic hysterectomy (TLH) with sentinel lymph node (SLN) mapping for low risk endometrial cancer. DESIGN: Retrospective cohort study (Canadian Task Force Classification Level II-2) SETTING: Academic university hospital PATIENTS: Patients with biopsy proven diagnosis of complex atypical hyperplasia (CAH) or low grade (1 or 2) endometrial cancer with body mass index less than 30 kg/m(2) and a undergoing robotic TLH and SLN mapping between 2012 and 2016 were included...
June 6, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28598368/self-assembled-lipid-nanoparticles-for-oral-delivery-of-heparin-coated-iron-oxide-nanoparticles-for-theranostic-purposes
#7
Eleonora Truzzi, Chiara Bongio, Francesca Sacchetti, Eleonora Maretti, Monica Montanari, Valentina Iannuccelli, Elena Vismara, Eliana Leo
Recently, solid lipid nanoparticles (SLNs) have attracted increasing attention owing to their potential as an oral delivery system, promoting intestinal absorption in the lymphatic circulation which plays a role in disseminating metastatic cancer cells and infectious agents throughout the body. SLN features can be exploited for the oral delivery of theranostics. Therefore, the aim of this work was to design and characterise self-assembled lipid nanoparticles (SALNs) to encapsulate and stabilise iron oxide nanoparticles non-covalently coated with heparin (Fe@hepa) as a model of a theranostic tool...
June 9, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28592414/effects-of-sarcolipin-deletion-on-skeletal-muscle-adaptive-responses-to-functional-overload-and-unload
#8
Val A Fajardo, Bradley A Rietze, Paige J Chambers, Catherine Bellissimo, Eric Bombardier, Joe Quadrilatero, A Russell Tupling
Overexpression of sarcolipin (SLN), a regulator of sarco(endo)plasmic reticulum Ca(2+)-ATPases (SERCAs), stimulates calcineurin signaling to enhance skeletal muscle oxidative capacity. Some studies have shown that calcineurin may also control skeletal muscle mass and remodeling in response to functional overload and unload stimuli by increasing myofiber size and the proportion of slow fibers. To examine whether SLN might mediate these adaptive responses we performed soleus and gastrocnemius tenotomy in wild-type (WT) and Sln¬-null (Sln(-/-)) mice and examined the overloaded plantaris and unloaded/tenotomized soleus muscles...
June 7, 2017: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/28584266/novel-rapid-immunohistochemistry-using-an-alternating-current-electric-field-for-intraoperative-diagnosis-of-sentinel-lymph-nodes-in-breast-cancer
#9
Kaori Terata, Hajime Saito, Hiroshi Nanjo, Yuko Hiroshima, Satoru Ito, Kasumi Narita, Yoichi Akagami, Ryuta Nakamura, Hayato Konno, Aki Ito, Satoru Motoyama, Yoshihiro Minamiya
Axillary lymph node status and pathological diagnosis of sentinel lymph nodes (SLNs) is a prognostic factor that influences management of postoperative therapy. Recent reports indicate that one-step nucleic acid amplification and hematoxylin and eosin (HE)-stained frozen sections are effective for intraoperative diagnosis of SLNs. In the present study, we report a rapid-immunohistochemical staining (R-IHC) method that enables intraoperative detection of SLN metastases within 16 min using an anti-cytokeratin antibody...
June 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28584240/synthetic-surfactant-and-cross-linker-free-preparation-of-highly-stable-lipid-polymer-hybrid-nanoparticles-as-potential-oral-delivery-vehicles
#10
Taoran Wang, Jingyi Xue, Qiaobin Hu, Mingyong Zhou, Chao Chang, Yangchao Luo
The toxicity associated with concentrated synthetic surfactants and the poor stability at gastrointestinal condition are two major constraints for practical applications of solid lipid nanoparticles (SLN) as oral delivery vehicles. In this study, a synthetic surfactant-free and cross-linker-free method was developed to fabricate effective, safe, and ultra-stable lipid-polymer hybrid nanoparticles (LPN). Bovine serum albumin (BSA) and dextran varying in molecular weights were first conjugated through Maillard reaction and the conjugates were exploited to emulsify solid lipid by a solvent diffusion and sonication method...
June 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28581831/development-and-characterization-of-new-and-scalable-topical-formulations-containing-n-acetyl-d-glucosamine-loaded-solid-lipid-nanoparticles
#11
Joana Marto, Cecilia Sangalli, Priscilla Capra, Paola Perugini, Andreia Ascenso, Lídia Gonçalves, Helena Ribeiro
N-Acetyl-d-glucosamine (NAG) has been recently considered for topical treatment of hyperpigmentation disorders due to its inhibitory effect on thyrosinase enzymes in melanocytes. NAG is a precursor of hyaluronic acid, increasing its amount in skin, and consequently, preserving the skin hydration and elasticity. It may also act as an emulsion stabilizer. Solid lipid nanoparticles (SLN) are advanced delivery systems successfully used in pharmaceutical and cosmetic formulations for the improvement of active molecules penetration into the skin...
June 21, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/28577885/isolated-tumor-cells-identified-by-sentinel-lymph-node-mapping-in-endometrial-cancer-does-adjuvant-treatment-matter
#12
Marie Plante, Jonathan Stanleigh, Marie-Claude Renaud, Alexandra Sebastianelli, Katherine Grondin, Jean Grégoire
OBJECTIVE: To evaluate the outcome and the role of adjuvant treatment in the management of patients with endometrial cancer and isolated tumor cells (ITCs) identified by SLN mapping. METHODS: This single center study identified all patients undergoing hysterectomy, salpingo-oophorectomy, lymphadenectomy and SLN mapping for endometrial cancer between November 2010 and December 2015. Data was prospectively collected. Progression-free survival was analyzed according to the Kaplan-Meier method and compared using the log-rank test...
May 31, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28576561/antimicrobial-activity-of-polymyxin-loaded-solid-lipid-nanoparticles-plx-sln-characterization-of-physicochemical-properties-and-in-vitro-efficacy
#13
Patrícia Severino, Elisânia F Silveira, Kahynna Loureiro, Marco V Chaud, Danilo Antonini, Marcelo Lancellotti, Victor Hugo Sarmento, Classius F da Silva, Maria Helena A Santana, Eliana B Souto
Antimicrobial resistance is a current public health concern, limiting the available therapeutic options used for the treatment of common bacterial infections. The development of new drug entities via biotechnological processes is however expensive and time-consuming. Therefore, old antimicrobial agents have been recovered for clinical use. An example of these drugs is polymyxin, which is known for its serious adverse side effects, such as nephrotoxicity, neurotoxicity and promotion of skin pigmentation. To overcome these limitations, the use of biodegradable nanoparticles has been proposed to allow site-specific targeting, increasing the drug's bioavailability and decreasing its side effects...
May 30, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28571944/indocyanine-green-versus-radiotracer-%C3%A2-blue-dye-for-sentinel-lymph-node-mapping-in-stage-ib1-cervical-cancer-2-cm
#14
Giampaolo Di Martino, Cinzia Crivellaro, Elena De Ponti, Beatrice Bussi, Andrea Papadia, Ignacio Zapardiel, Enrico Vizza, Federica Elisei, Maria Dolores Diestro, Luca Locatelli, Maria Luisa Gasparri, Paolo Di Lorenzo, Michael Mueller, Alessandro Buda
STUDY OBJECTIVE: To compare sentinel lymph node (SLN) mapping in women with cervical cancer stage > IB1 (tumor > 2 cm) by using indocyanine green (ICG) versus the standard radioisotope technetium 99m radiocolloid (Tc99(m)) radiotracer ± blue-dye technique. DESIGN: European multicenter, retrospective observational study (Canadian Task Force Classification II-2) SETTING: Four academic medical centers PATIENTS: 95 women with stage IB1 (> 2 cm) who underwent SLN mapping with Tc99(m) ± blue dye or ICG and radical hysterectomy INTERVENTION: Detection rate and bilateral mapping rate of ICG were compared with those obtained using the standard Tc99(m) radiotracer ± blue dye...
May 29, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28570748/sensitivity-and-specificity-of-indocyanine-green-near-infrared-fluorescence-imaging-in-detection-of-metastatic-lymph-nodes-in-colorectal-cancer-systematic-review-and-meta-analysis
#15
REVIEW
Sameh H Emile, Hossam Elfeki, Mostafa Shalaby, Ahmad Sakr, Pierpaolo Sileri, Søren Laurberg, Steven D Wexner
This review aimed to determine the overall sensitivity and specificity of indocyanine green (ICG) near-infrared (NIR) fluorescence in sentinel lymph node (SLN) detection in Colorectal cancer (CRC). A systematic search in electronic databases was conducted. Twelve studies including 248 patients were reviewed. The median sensitivity, specificity, and accuracy rates were 73.7, 100, and 75.7. The pooled sensitivity and specificity rates were 71% and 84.6%. In conclusion, ICG-NIR fluorescence is a promising technique for detecting SLNs in CRC...
June 1, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28569457/advances-in-radioguided-surgery-in-oncology
#16
Renato A Valdés Olmos, Sergi Vidal-Sicart, Gianpiero Manca, Giuliano Mariani, Luisa F León-Ramírez, Domenico Rubello, Francesco Giammarile
The sentinel lymph node (SLN) biopsy is probably the most well known radioguided technique in surgical oncology. Today SLN biopsy reduces the morbidity associated with lymphadenectomy and increases the identification rate of occult lymphatic metastases by offering the pathologist the lymph nodes with the highest probability of containing metastatic cells. These advantages may result in a change in clinical clinical management both in melanoma and breast cancer patients. The SLN evaluation by pathology currently implies tumour burden stratification for further prognostic information...
June 1, 2017: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28566221/sentinel-lymph-node-mapping-and-staging-in-endometrial-cancer-a-society-of-gynecologic-oncology-literature-review-with-consensus-recommendations
#17
REVIEW
Robert W Holloway, Nadeem R Abu-Rustum, Floor J Backes, John F Boggess, Walter H Gotlieb, W Jeffrey Lowery, Emma C Rossi, Edward J Tanner, Rebecca J Wolsky
The emphasis in contemporary medical oncology has been "precision" or "personalized" medicine, terms that imply a strategy to improve efficacy through targeted therapies. Similar attempts at precision are occurring in surgical oncology. Sentinel lymph node (SLN) mapping has recently been introduced into the surgical staging of endometrial cancer with the goal to reduce morbidity associated with comprehensive lymphadenectomy, yet obtain prognostic information from lymph node status. The Society of Gynecologic Oncology's (SGO) Clinical Practice Committee and SLN Working Group reviewed the current literature for preparation of this document...
May 28, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28558116/sentinel-lymph-node-technique-in-endometrial-cancer
#18
Allison Staley, Stephanie A Sullivan, Emma C Rossi
Importance: Endometrial cancer (EMCA) is the most common gynecologic malignancy, with an estimated 54,000 new cases and 10,000 deaths in the United States in 2015. Lymph node metastasis is the most significant prognostic factor in EMCA. Sentinel lymph node (SLN) mapping has become a well-accepted procedure in surgical oncology and may strike a balance between the risks and benefits of lymphadenectomy. Objective: The aim of this study was to review the current literature regarding the history, techniques, and clinical application of SLN mapping in EMCA...
May 2017: Obstetrical & Gynecological Survey
https://www.readbyqxmd.com/read/28555886/lymphatic-invasion-predicts-sentinel-lymph-node-metastasis-and-adverse-outcome-in-primary-cutaneous-melanoma
#19
Andrea P Moy, Mark C Mochel, Alona Muzikansky, Lyn M Duncan, Stefan Kraft
BACKGROUND: Sentinel lymph node (SLN) metastasis is a powerful predictor of survival in primary cutaneous melanoma. Lymphatic invasion (LI) may correlate with increased risk of SLN metastasis. Intralymphatic metastases, often difficult to detect on hematoxylin and eosin (H&E) stained sections, are readily identified with dual immunohistochemistry for melanocytic and lymphatic markers. METHODS: We used dual S100/D240 immunohistochemistry to detect LI in 125 melanomas from patients who underwent SLN biopsy and correlated LI with melanoma staging parameters and disease status...
May 29, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28555014/in-vitro-antioxidant-activity-of-idebenone-derivative-loaded-solid-lipid-nanoparticles
#20
Lucia Montenegro, Maria N Modica, Loredana Salerno, Anna Maria Panico, Lucia Crascì, Giovanni Puglisi, Giuseppe Romeo
Idebenone (IDE) has been proposed for the treatment of neurodegenerative diseases involving mitochondria dysfunctions. Unfortunately, to date, IDE therapeutic treatments have not been as successful as expected. To improve IDE efficacy, in this work we describe a two-step approach: (1) synthesis of IDE ester derivatives by covalent linking IDE to other two antioxidants, trolox (IDETRL) and lipoic acid (IDELIP), to obtain a synergic effect; (2) loading of IDE, IDETRL, or IDELIP into solid lipid nanoparticles (SLN) to improve IDE and its esters' water solubility while increasing and prolonging their antioxidant activity...
May 27, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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