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https://www.readbyqxmd.com/read/28921419/sentinel-lymph-node-biopsy-in-endometrial-cancer-a-new-standard-of-care
#1
REVIEW
Stephanie A Sullivan, Emma C Rossi
Lymph node status is one of the most important factors in determining prognosis and the need for adjuvant treatment in endometrial cancer (EMCA). Unfortunately, full lymphadenectomy bears significant surgical and postoperative risks. The majority of patients with clinical stage I disease will not have metastatic disease; thus, a full lymphadenectomy only increases morbidity in this population of patients. The use of the sentinel lymph node (SLN) biopsy has emerged as an alternative to complete lymphadenectomy in EMCA...
September 18, 2017: Current Treatment Options in Oncology
https://www.readbyqxmd.com/read/28919095/laparoscopic-near-infrared-fluorescent-imaging-as-an-alternative-option-for-sentinel-lymph-node-mapping-in-endometrial-cancer-a-prospective-study
#2
Salih Taşkın, Yavuz Emre Şükür, Duygu Altın, Cevriye Cansız Ersöz, Batuhan Turgay, Duygu Kankaya, Mete Güngör, Fırat Ortaç
BACKGROUND: To evaluate feasibility of sentinel lymph node (SLN) mapping by using near-infrared fluorescent imaging and indocyanine green (NIR/ICG) integrated laparoscopic system in clinically uterine-confined endometrial cancer. MATERIALS AND METHODS: Patients with clinically early-stage endometrial cancer were included in this prospective study. ICG was injected to the uterine cervix and NIR/ICG integrated laparoscopic system (Spies Full HD D-Light P ICG technology, Karl Storz, Tuttlingen, Germany) was used during the operations...
September 14, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28919031/a-pilot-study-to-assess-near-infrared-laparoscopy-with-indocyanine-green-icg-for-intraoperative-sentinel-lymph-node-mapping-in-early-colon-cancer
#3
A C Currie, A Brigic, S Thomas-Gibson, N Suzuki, M Moorghen, J T Jenkins, O D Faiz, R H Kennedy
BACKGROUND: Previous attempts at sentinel lymph node (SLN) mapping in colon cancer have been compromised by ineffective tracers and the inclusion of advanced disease. This study evaluated the feasibility of fluorescence detection of SLNs with indocyanine green (ICG) for lymphatic mapping in T1/T2 clinically staged colonic malignancy. METHODS: Consecutive patients with clinical T1/T2 stage colon cancer underwent endoscopic peritumoral submucosal injection of indocyanine green (ICG) for fluorescence detection of SLN using a near-infrared (NIR) camera...
August 23, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28911663/recent-advances-in-oral-delivery-of-drugs-and-bioactive-natural-products-using-solid-lipid-nanoparticles-as-the-carriers
#4
REVIEW
Chih-Hung Lin, Chun-Han Chen, Zih-Chan Lin, Jia-You Fang
Chemical and enzymatic barriers in the gastrointestinal (GI) tract hamper the oral delivery of many labile drugs. The GI epithelium also contributes to poor permeability for numerous drugs. Drugs with poor aqueous solubility have difficulty dissolving in the GI tract, resulting in low bioavailability. Nanomedicine provides an opportunity to improve the delivery efficiency of orally administered drugs. Solid lipid nanoparticles (SLNs) are categorized as a new generation of lipid nanoparticles consisting of a complete solid lipid matrix...
April 2017: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28900723/diagnostic-value-of-sentinel-lymph-node-biopsy-for-ct1-t2n0-tongue-squamous-cell-carcinoma-a-meta-analysis
#5
REVIEW
Yue Yang, Jian Zhou, Haitao Wu
The aim of this study was to systematically evaluate the diagnostic value of the sentinel lymph node biopsy (SLNB) for cT1/T2N0 tongue squamous cell carcinoma (TSCC) patients. A comprehensive and systematic literature review was performed by searching the Embase and PubMed databases for English language articles published up to December 2016. The pooled overall sentinel lymph node (SLN) detection rate, sensitivity and negative predictive value (NPV) were used to evaluate the diagnostic value of SLNB which used neck dissection or follow-up as a reference test...
September 12, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28890335/the-er-localized-transmembrane-protein-epg-3-vmp1-regulates-serca-activity-to-control-er-isolation-membrane-contacts-for-autophagosome-formation
#6
Yan G Zhao, Yong Chen, Guangyan Miao, Hongyu Zhao, Wenyan Qu, Dongfang Li, Zheng Wang, Nan Liu, Lin Li, She Chen, Pingsheng Liu, Du Feng, Hong Zhang
During autophagosome formation in mammalian cells, isolation membranes (IMs; autophagosome precursors) dynamically contact the ER. Here, we demonstrated that the ER-localized metazoan-specific autophagy protein EPG-3/VMP1 controls ER-IM contacts. Loss of VMP1 causes stable association of IMs with the ER, thus blocking autophagosome formation. Interaction of WIPI2 with the ULK1/FIP200 complex and PI(3)P contributes to the formation of ER-IM contacts, and these interactions are enhanced by VMP1 depletion. VMP1 controls contact formation by promoting SERCA (sarco[endo]plasmic reticulum calcium ATPase) activity...
September 6, 2017: Molecular Cell
https://www.readbyqxmd.com/read/28884598/skin-targeting-of-curcumin-solid-lipid-nanoparticles-engrossed-topical-gel-for-the-treatment-of-pigmentation-and-irritant-contact-dermatitis
#7
Shilpa Shrotriya, Nisharani Ranpise, Pournima Satpute, Bhagvat Vidhate
Irritant contact dermatitis (ICD) and hyperpigmentation are the problems associated with skin. Topical curcumin (CUR) although effective in hyperpigmentation and ICD, is a challenging molecule due to low-solubility. Encapsulation of CUR into solid lipid nanoparticles (SLNs) makes it amenable to topical dosing as their small size promotes its penetration into the skin. CUR-SLNs were prepared using Precirol ATO5 and Tween-80 by probe ultrasonication method. Further, CUR-SLNs were incorporated into Carbopol gel and investigated for ex-vivo skin permeation, skin deposition and skin irritation studies...
September 8, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28877063/sentinel-lymph-nodes-in-classic-invasive-lobular-carcinoma-of-the-breast-cytokeratin-immunostain-ensures-detection-and-precise-determination-of-extent-of-involvement
#8
Ami Patel, Timothy D'Alfonso, Esther Cheng, Syed A Hoda
The assessment of sentinel lymph nodes (SLN) on hematoxylin and eosin (H&E)-stained sections in cases of classic type of invasive lobular carcinoma (cILC) is considered unreliable, particularly in cases with minimal involvement, that is by either isolated tumor cells (pN0i+) or micrometastases (pN1mi). Although the impact of minimal SLN involvement has been shown to be insignificant in most clinical trials (even though cILC was either under-represented or not separated in the respective cohorts), the results of MIRROR trial did emphasize the need for additional therapy in cases with minimally involved SLN to ensure improved disease-free survival...
September 4, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28873589/control-of-the-gastrointestinal-digestion-of-solid-lipid-nanoparticles-using-pegylated-emulsifiers
#9
Choongjin Ban, Myeongsu Jo, Seokwon Lim, Young Jin Choi
We prepared solid lipid nanoparticles (SLNs) with tristearin and various emulsifiers which had different chain length PEGs (10-100 times-repetition of ethylene glycol) to control their digestion fate in the gastrointestinal tract. Fabricated SLNs after acidic/high-ionic-strength media treatment were stable regardless of the ζ-potential (ZP) disappearance. Additionally, highly PEGylated SLNs successfully hindered the adsorption of both bile acid (BA) and lipase on the SLN surface, while lowly PEGylated SLNs interrupted that of only lipase...
January 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/28873443/application-of-carbon-nanoparticles-in-laparoscopic-sentinel-lymph-node-detection-in-patients-with-early-stage-cervical-cancer
#10
Yan Lu, Jin-Ying Wei, De-Sheng Yao, Zhong-Mian Pan, Yao Yao
OBJECTIVE: To investigate the value of carbon nanoparticles in identifying sentinel lymph nodes in early-stage cervical cancer. METHODS: From January 2014 to January 2016, 40 patients with cervical cancer stage IA2-IIA, based on the International Federation of Gynecology and Obstetrics (FIGO) 2009 criteria, were included in this study. The normal cervix around the tumor was injected with a total of 1 mL of carbon nanoparticles (CNP)at 3 and 9 o'clock. All patients then underwent laparoscopic pelvic lymph node dissection and radical hysterectomy...
2017: PloS One
https://www.readbyqxmd.com/read/28871923/predictive-value-of-intraoperative-sentinel-lymph-node-imprint-cytology-analysis-for-metastasis-in-patients-with-melanoma
#11
Nives Jonjić, Koraljka Rajković Molek, Irena Seili-Bekafigo, Svjetlana Grbac Ivanković, Neva Girotto, Davor Jurišić, Gordana Zamolo, Ira Pavlović Ružić, Larisa Prpić Massari
Since there are no standardized protocols regarding the detection of microscopic melanoma deposits in sentinel lymph nodes (SLN), the aim of this study was to present our experience with intraoperative cytological evaluation of SLN in patients with melanoma. The study included 475 SLN biopsies (SLNB) from 201 patients with primary cutaneous melanoma of intermediate thickness. Each lymph node was cut in half; touch imprint cytology (TIC) preparations of all cut surfaces were performed and stained according to a modified May-Grünwald-Giemsa method...
July 2017: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/28870403/high-antigen-processing-machinery-component-expression-in-langerhans-cells-from-melanoma-patients-sentinel-lymph-nodes
#12
Maria Raffaella Romoli, Paola Di Gennaro, Gianni Gerlini, Serena Sestini, Paola Brandani, Soldano Ferrone, Lorenzo Borgognoni
Langerhans cells (LCs) from melanoma patients sentinel lymph nodes (SLN) are poor T cell activators mostly due to an immature immunophenotype. However Antigen Presenting Machinery (APM) role is unknown. We investigated HLA-class I APM components (Delta, LMP-7/10, TAP-1, Calnexin, Tapasin, β2-microglobulin and HLA-A,B,C) in LCs from healthy donors skin and melanoma patients SLN. APM component levels were low in immature epidermal LCs and significantly increased after maturation (p<0.05); their levels were significantly high in SLN LCs (p<0...
August 30, 2017: Cellular Immunology
https://www.readbyqxmd.com/read/28869832/sentinel-lymph-node-biopsy-in-chinese-patients-with-large-operable-breast-cancer-%C3%A2-4%C3%A2-cm-a-decade-s-experience-from-a-single-institution
#13
Yang Yang, Yingjian He, Zhaoqing Fan, Tao Ouyang
BACKGROUND: Performing sentinel lymph node biopsy (SLNB) in patients with large operable breast cancer is still controversial. Our aim is to find whether or not performing SLNB is feasible and safety in Chinese patients with large operable breast cancer. METHODS: We reviewed the data of patients in our center from 2003 to 2015, a series of 267 patients with large operable breast cancer (≥4 cm) who underwent SLNB were examined. All selected patients recieved preoperative axillary evaluation...
August 31, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28861856/role-of-sentinel-node-in-differentiated-thyroid-cancer-a-prospective-study-comparing-patent-blue-injection-technique-lymphoscintigraphy-and-the-combined-technique
#14
R Gelmini, M Campanelli, F Cabry, A Franceschetto, G Ceresini, L Ruffini, A Zaccaroni, P Del Rio
PURPOSE: The purpose of the present study was to evaluate the feasibility and reproducibility of the sentinel lymph node (SLNs) biopsy in differentiated thyroid cancer using patent blue injection, lymphoscintigraphy and the combined techniques. METHODS: Between January 2011 and January 2013, 82 consecutive patients were enrolled in our prospective multicentre study. Inclusion criteria were 18 years of age, preoperative diagnosis of differentiated thyroid carcinoma, no evidence of lymph node enlargement and multifocal neoplasm...
August 31, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28861665/non-visualized-sentinel-nodes-in-breast-cancer-patients-prevalence-risk-factors-and-prognosis
#15
N C Verheuvel, A C Voogd, V C G Tjan-Heijnen, S Siesling, R M H Roumen
BACKGROUND: Evidence and consensus is lacking in international guidelines regarding axillary treatment recommendations for patients in whom a sentinel lymph node (SLN) cannot be visualized (non-vSLN) during the sentinel node procedure. In this study we aimed to determine the prevalence of non-vSLNs in a Dutch population of breast cancer patients and to examine predictors and survival rate for non-vSLN. METHODS: A nationwide, retrospective, population-based study was performed including 116,920 patients with invasive breast cancer who underwent a SLN procedure in the Netherlands between January 2005 and December 2013...
August 31, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28851416/interim-analysis-of-survival-in-a-prospective-multi-center-registry-cohort-of-cutaneous-melanoma-tested-with-a-prognostic-31-gene-expression-profile-test
#16
Eddy C Hsueh, James R DeBloom, Jonathan Lee, Jeffrey J Sussman, Kyle R Covington, Brooke Middlebrook, Clare Johnson, Robert W Cook, Craig L Slingluff, Kelly M McMasters
BACKGROUND: A 31-gene expression profile (GEP) test that provides risk classification of cutaneous melanoma (CM) patients has been validated in several retrospective studies. The objective of the reported study was a prospective evaluation of the GEP performance in patients enrolled in two clinical registries. METHODS: Three-hundred twenty two CM patients enrolled in the EXPAND (NCT02355587) and INTEGRATE (NCT02355574) registries met the criteria of age ≥ 16 years, successful GEP result and ≥1 follow-up visit for inclusion in this interim analysis...
August 29, 2017: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/28843225/managing-the-axilla-in-early-breast-cancer-impact-of-acosog-z0011-trial-in-changing-practices-in-a-low-middle-income-country
#17
Awais Amjad Malik, Namra Urooj, Romaisa Shamim, Mariam Salim, Razia Bano, Zulqurnain Chaudhry, Huma Majeed Khan, Amina Iqbal Khan
Objective: To determine the impact of the trial on surgeon practice patterns at our institution. Methodology: A comparison of patients undergoing surgery for early breast cancer before and after the implementation of the new guidelines was done. We adopted the new guidelines in April 2015. Patients meeting Z0011 inclusion criteria were identified. For group A (Pre Z0011) patients operated between Jan to Dec 2013 were studied. And for Group B (Post Z0011) patients operated between July 2014 to Jun 2015 were included...
August 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28842128/formulation-optimization-characterization-and-evaluation-of-in-vitro-cytotoxic-potential-of-curcumin-loaded-solid-lipid-nanoparticles-for-improved-anticancer-activity
#18
Sri Vishnu Kiran Rompicharla, Himanshu Bhatt, Aashma Shah, Neeraja Komanduri, Dhanya Vijayasarathy, Balaram Ghosh, Swati Biswas
The aim of the present research was to develop a novel, biocompatible, amenable to industrial scale up and affordable solid lipid nanoparticles (SLN) preparation of curcumin and evaluate the therapeutic efficacy in vitro using cancer cells. We have incorporated cholesterol as the lipid to prepare SLN along with the Poloxamer-188 as stabilizer. High shear homogenization was used to prepare the SLN and formulation was optimized using Quality by Design The optimized Chol CUR SLN exhibited a narrow size distribution with a particle size of 166...
August 23, 2017: Chemistry and Physics of Lipids
https://www.readbyqxmd.com/read/28839123/predictive-value-of-clinicopathological-characteristics-for-sentinel-lymph-node-metastasis-in-early-breast-cancer
#19
Jinhua Ding, Li Jiang, Weizhu Wu
BACKGROUND Sentinel lymph node biopsy (SLNB) is one of the preferred treatments for breast cancer including clinically negative lymph node breast cancer. However, for 60-70% of patients this invasive axilla surgery is unnecessary. Our study aimed to identify the predictors for sentinel lymph node (SLN) metastasis in early breast cancer patients and provide evidence for rational decision-making in specified clinical situations. MATERIAL AND METHODS Medical records of 417 breast cancer patients who were treated with a breast surgical procedure and SLNB in Ningbo Medical Center Lihuili Eastern Hospital were retrospectively reviewed...
August 25, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28828635/preoperative-prediction-of-sentinel-lymph-node-metastasis-in-breast-cancer-based-on-radiomics-of-t2-weighted-fat-suppression-and-diffusion-weighted-mri
#20
Yuhao Dong, Qianjin Feng, Wei Yang, Zixiao Lu, Chunyan Deng, Lu Zhang, Zhouyang Lian, Jing Liu, Xiaoning Luo, Shufang Pei, Xiaokai Mo, Wenhui Huang, Changhong Liang, Bin Zhang, Shuixing Zhang
OBJECTIVES: To predict sentinel lymph node (SLN) metastasis in breast cancer patients using radiomics based on T2-weighted fat suppression (T2-FS) and diffusion-weighted MRI (DWI). METHODS: We enrolled 146 patients with histologically proven breast cancer. All underwent pretreatment T2-FS and DWI MRI scan. In all, 10,962 texture and four non-texture features were extracted for each patient. The 0.623 + bootstrap method and the area under the curve (AUC) were used to select the features...
August 21, 2017: European Radiology
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