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https://www.readbyqxmd.com/read/29166577/cell-cycle-related-kinase-regulates-mammalian-eye-development-through-positive-and-negative-regulation-of-the-hedgehog-pathway
#1
Floria I Lupu, Jacob B Burnett, Jonathan T Eggenschwiler
Cell cycle-related kinase (CCRK) is a conserved regulator of ciliogenesis whose loss in mice leads to a wide range of developmental defects, including exencephaly, preaxial polydactyly, skeletal abnormalities, and microphthalmia. Here, we investigate the role of CCRK in mouse eye development. Ccrk mutants show dramatic patterning defects, with an expansion of the optic stalk domain into the optic cup, as well as an expansion of the retinal pigment epithelium (RPE) into neural retina (NR) territory. In addition, Ccrk mutants display a shortened optic stalk...
November 19, 2017: Developmental Biology
https://www.readbyqxmd.com/read/29166534/effect-of-syzygium-cumini-leaves-on-laying-hens-performance-and-egg-quality
#2
Ednardo R Freitas, Danilo R Fernandes, Davyd H Souza, Francisco D T Dantas, Rebeca C Santos, Gilson B Oliveira, Carlos Eduardo B Cruz, Nádia M Braz, Lorena F Câmara, Germano A J Nascimento, Pedro H Watanabe
The aim of this study was to evaluate the effect of Syzygium cumini leaves (SCL) in laying hens diets on productive performance, egg quality and lipid oxidation of yolk. A total of 108 Hysex White laying hens were distributed in a completely randomized design with three treatments and six replicates of six birds each. The treatments consisted of SCL inclusion at dietary levels of 0, 5 and 10 g/kg. There was no significant effect of SCL inclusion on feed intake, laying percentage, weight and egg mass, feed conversion ratio, Haugh units, specific gravity, percentage of yolk, albumen and egg shells and shell thickness...
2017: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/29166512/segmental-lichen-aureus-an-uncommon-presentation
#3
Pedro de Freitas Silva Torraca, Nathalia Dias Negrão Murback, Nayara de Castro Wiziack, Tânia Christina Marchesi de Freitas, Greicy Mara França
Pigmented purpuric dermatoses are chronic vascular inflammatory conditions characterized by the presence of pigmented macules. Among its different presentations, lichen aureus is distinguished by the lichenoid conformation of its plaques and the predilection for lower limb involvement. Its segmented form is rare and difficult to control, especially in cases of symptomatic lesions. We report a rare case of segmental lichen aureus with six years of evolution associated with light itching. We also discuss the main therapeutic approaches to control the disease...
September 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29166507/pigmented-bowen-s-disease-associated-with-high-risk-hpv-simulating-melanoma-of-the-hand
#4
Rute Facchini Lellis, John Verrinder Veasey, Renata Diniz Jacques Gonçalves
Bowen's disease is an in situ squamous cell carcinoma of the skin with only 2% of pigmented cases reported. It is clinically characterized by papules and plaques of blackened surface that may be caused either by sun damage - usually in photoexposed areas in elderly individuals - or by human papillomavirus infection - usually in the anogenital region of young adults. Dermoscopic aspects of Bowen's disease are discussed for over a decade, but with no definitive criteria that would lead to a definitive diagnosis...
September 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29166493/dystrophic-calcification-of-maxillary-sinus-in-pediatric-patients-with-liver-transplantation-and-pigmentation-of-dental-organ
#5
Adriana Furtado de Macedo, Claudio Costa, Regina Helena Guedes da Motta Mattar, Ramiro Anthero de Azevedo
OBJECTIVE: To report a case of severe dystrophic calcification in maxillary sinus of a child with liver transplantation and dental organs pigmented by hyperbilirubinemia. CASE DESCRIPTION: female patient, 12 years old, with liver transplantation performed at the age of 7 due to extrahepatic biliary atresia (EHBA). The patient was receiving the immunosuppressant tacrolimus (2 mg daily). Intraoral clinical exam showed tooth green pigmentation by bilirubin. Cone-beam volumetric computed tomography (CT) was performed to verify radiographic density of pigmented dental elements...
November 17, 2017: Revista Paulista de Pediatria: Orgão Oficial da Sociedade de Pediatria de São Paulo
https://www.readbyqxmd.com/read/29166140/comparison-of-short-term-choroidal-thickness-and-retinal-morphological-changes-after-intravitreal-anti-vegf-therapy-with-ranibizumab-or-aflibercept-in-treatment-naive-eyes
#6
Magda Gharbiya, Rosalia Giustolisi, Jessica Marchiori, Alice Bruscolini, Fabiana Mallone, Valeria Fameli, Marcella Nebbioso, Solmaz Abdolrahimzadeh
PURPOSE: To evaluate choroidal thickness (CT) and retinal morphological changes in eyes with neovascular age-related macular degeneration (nAMD) following ranibizumab or aflibercept intravitreal treatment. MATERIALS AND METHODS: This was a prospective, observational, comparative study where 76 eyes of 76 consecutive patients with treatment-naive nAMD were consecutively enrolled and randomized to ranibizumab 0.5 mg or aflibercept 2 mg injections. Spectral-domain optical coherence tomography images of the choroid were obtained by enhanced depth imaging modality...
November 22, 2017: Current Eye Research
https://www.readbyqxmd.com/read/29165479/evaluation-of-the-impact-of-food-matrix-change-on-the-in-vitro-bioaccessibility-of-carotenoids-in-pumpkin-cucurbita-moschata-slices-during-two-drying-processes
#7
Zhongyuan Zhang, Xiaoyan Wang, Yixiang Li, Qiuyu Wei, Chunju Liu, Meimei Nie, Dajing Li, Yadong Xiao, Chunquan Liu, Lang Xu, Min Zhang, Ning Jiang
The food matrix is a limiting factor in determining the bioaccessibility of carotenoids. The impact of food matrix change on the bioaccessibility of carotenoids during drying processes is still unknown. The effect of intermittent microwave vacuum-assisted drying (IMVD) and hot air drying (HAD) on the in vitro liberation and micellization of carotenoids in pumpkin slices was studied. This variable depended on the changes of the matrix driven by the drying process. Different changes in the cell morphology and carotenoid distribution of pumpkin slices during the two processing methods were observed...
November 22, 2017: Food & Function
https://www.readbyqxmd.com/read/29165457/the-chemical-composition-nutritional-value-and-antimicrobial-properties-of-abelmoschus-esculentus-seeds
#8
Spyridon Petropoulos, Ângela Fernandes, Lillian Barros, Ana Ciric, Marina Sokovic, Isabel C F R Ferreira
Okra is a vegetable crop usually used for its immature pods. The harvest stage (fruit size) depends on consumers' preferences and the fruit that does not meet market requirements is being disposed of. Considering the short time interval from the setting of the fruit to the harvest stage, the present study evaluates the nutritional value, chemical composition, and antioxidant and antimicrobial properties of okra seeds from genotypes cultivated under Mediterranean conditions, as an alternative end-use product...
November 22, 2017: Food & Function
https://www.readbyqxmd.com/read/29165414/-torpedo-macu-lopathy-clinical-case
#9
A S Stoyukhina, N V Zhorzholadze, S S Danilov
The article presents a clinical case of torpedo maculopathy. This congenital disorder is most likely to be caused by changes in the retinal pigment epithelium (RPE) during retinal fissure closure. Visual function is usually unaffected and the condition is revealed at routine ophthalmic examination in children and teens. Optical coherence tomography showed the absence of RPE, photoreceptor damage, and massive thinning of the outer nuclear layer at the diseased site without a significant change in the total retinal thickness...
2017: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/29165406/-the-significance-of-fibroblasts-in-experimental-modeling-of-proliferative-vitreoretinopathy
#10
I P Khoroshilova-Maslova, N L Leparskaya, E A Vorotelyak, A V Vasiliev
AIM: to investigate the role of heterogeneous fibroblasts in the development of epiretinal membrane in eyes with modeled proliferative vitreoretinopathy. MATERIAL AND METHODS: The material for investigation were 6 eyes of 3 Chinchilla rabbits. Suspended fibroblasts (fibroblasts of the human skin - 200000 cells in 0.1 ml) were injected into the vitreous cavity via the pars plana. The animals were followed up for 1 month and then made out of the experiment. The eyes were enucleated and fixed in 10% neutral buffered formalin for routine histological examination...
2017: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/29164778/open-label-study-assessing-the-efficacy-and-tolerability-of-topical-skincare-and-sun-protection-products-following-intense-pulsed-light-treatment
#11
Isabela T Jones, Isabella Guiha, Sabrina G Fabi
BACKGROUND: The visible signs of photodamage can be improved by intense pulsed light (IPL). Active ingredients in cosmeceuticals also have effects on skin quality and pigmentation, and can camouflage post-treatment side effects. Combination therapies utilizing different treatment modalities have been shown to optimize clinical outcomes for skin rejuvenation and patient satisfaction. AIM: To evaluate the efficacy of a combination of IPL with a daily topical skincare and sunscreen regimen for the treatment of facial photodamage and for the improvement of IPL treatment tolerability...
November 21, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29164466/bioagents-and-silicon-promoting-fast-early-upland-rice-growth
#12
Thatyane Pereira de Sousa, Alan Carlos Alves de Souza, Marta Cristina Corsi de Filippi, Anna Cristina Lanna, Marcio Vinicius Cortês, Hugo Alves Pinheiro, Gisele Barata da Silva
Upland rice can overcome major challenges through the insertion of silicate fertilization and the presence of plant growth-promoting microorganisms (PGPMs) during its cultivation, as these factors promote an increase in vigor and plant disease resistance. Two consecutive experiments were conducted to evaluate the beneficial effects of silicon fertilization combined with the PGPM, Pseudomonas fluorensces, Burkholderia pyrrocinia, and a pool of Trichoderma asperellum, in upland rice seedlings, cultivar BRS Primavera CL: (a) E1, selecting PGPM type and Si doses for rice growth promotion and leaf blast supression, and (b) E2, evaluating physiological characteristics correlated with mechanisms involved in the higher vegetative growth in highlighted treatments from E1...
November 21, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29164181/gingival-depigmentation-using-er-yag-laser-and-scalpel-technique-a-six-month-prospective-clinical-study
#13
Rola Alhabashneh, Obaida Darawi, Yousef S Khader, Lama Ashour
OBJECTIVE: To compare the 6-month clinical efficacy of Er:YAG laser and standard scalpel technique in treating gingival hyperpigmentation. METHOD AND MATERIALS: Patients requesting treatment for moderate to severe gingival hyperpigmentation in the maxilla were enrolled in this split-mouth study. The contralateral maxillary sides were randomly assigned to receive either Er:YAG laser (continuous wavelength of 2,940 nm) with a noncontact tip or the standard scalpel technique...
November 21, 2017: Quintessence International
https://www.readbyqxmd.com/read/29163788/mind4-17-protects-retinal-pigment-epithelium-cells-and-retinal-ganglion-cells-from-uv
#14
Chaopeng Li, Kang Yan, Wenqi Wang, Qing Bai, Changming Dai, Xiaofeng Li, Darui Huang
Nrf2 activation would efficiently protect retinal cells from UV radiation (UVR). Recent studies have developed a Nrf2-targeting thiazole-containing compound MIND4-17, which activates Nrf2 through blocking its association with Keap1. In the current study, we demonstrated that pretreatment with MIND4-17 efficiently protected retinal pigment epithelium (RPE) cells (RPEs) and retinal ganglion cells (RGCs) from UVR. UVR-induced apoptosis in the retinal cells was also largely attenuated by MIND4-17 pretreatment. MIND4-17 presumably separated Nrf2 from Keap1, allowing its stabilization and accumulation in retinal cells, which then translocated to cell nuclei and promoted transcription of ARE-dependent anti-oxidant genes, including HO1, NQO1 and GCLM...
October 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/29163105/seeing-a-blush-on-the-visible-and-invisible-spectrum-a-functional-thermal-infrared-imaging-study
#15
Stephanos Ioannou, Paul H Morris, Marc Baker, Vasudevi Reddy, Vittorio Gallese
So far blushing has been examined in the context of a negative rather than a positive reinforcement where visual displays of a blush were based on subjective measures. The current study used infrared imaging to measure thermal patterns of the face while with the use of a video camera quantified on the visible spectrum alterations in skin color related to a compliment. To elicit a blush a three-phase dialog was adopted ending or starting with a compliment on a female sample (N = 22). When the dialog ended with a compliment results showed a linear increase in temperature for the cheek, and forehead whereas for the peri-orbital region a linear decrease was observed...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29162627/a-therapeutic-combination-of-gpcr-modulators-that-protects-photoreceptors-from-degeneration
#16
Tivadar Orban, Henri Leinonen, Tamar Getter, Zhiqian Dong, Wenyu Sun, Songqi Gao, Alexander Veenstra, Hossein Heidari-Torkabadi, Timothy S Kern, Philip D Kiser, Krzysztof Palczewski
Degeneration of retinal photoreceptor cells can arise from environmental and/or genetic causes. Since photoreceptor cells, the retinal pigment epithelium (RPE), neurons and glial cells of the retina are intimately associated; all cell types eventually are affected by retinal degenerative diseases. Such diseases often originate either in rod and/or cone photoreceptor cells or the RPE. Of these, cone cells located in the central retina are especially important for daily human activity. Here we describe the protection of cone cells by a combination therapy consisting of the G protein-coupled receptor modulators metoprolol, tamsulosin, and bromocriptine...
November 21, 2017: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29162523/specific-visualization-of-neuromelanin-iron-complex-and-ferric-iron-in-the-human-post-mortem-substantia-nigra-using-mr-relaxometry-at-7t
#17
Hansol Lee, Sun-Yong Baek, Se Young Chun, Jae-Hyeok Lee, HyungJoon Cho
Neuromelanin (NM) is an endogenous iron chelating molecule of pigmented neurons in the human substantia nigra (SN). Along with the increase in iron deposition, the reduction in NM-containing dopaminergic neurons and the variation of iron load on NM are generally considered to be important factors participating to pathogenesis of Parkinson's disease (PD). The aim of this study was to non-invasively delineate the spatial distributions of paramagnetic magnetic susceptibility perturbers, such as NM-iron complex and ferric iron in SN...
November 18, 2017: NeuroImage
https://www.readbyqxmd.com/read/29162497/expression-signatures-of-early-stage-and-advanced-medaka-melanomas
#18
Barbara Klotz, Susanne Kneitz, Martina Regensburger, Lena Hahn, Michael Dannemann, Janet Kelso, Birgit Nickel, Yuan Lu, William Boswell, John Postlethwait, Wesley Warren, Manfred Kunz, Ronald B Walter, Manfred Schartl
Melanoma is one of the most aggressive tumors with a very low survival rate once metastasized. The incidence of newly detected cases increases every year suggesting the necessity of development and application of innovative treatment strategies. Human melanoma develops from melanocytes localized in the epidermis of the skin to malignant tumors because of deregulated effectors influencing several molecular pathways. Despite many advances in describing the molecular changes accompanying melanoma formation, many critical and clinically relevant molecular features of the transformed pigment cells and the underlying mechanisms are largely unknown...
November 18, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/29162465/linoleic-acid-enhance-the-production-of-moncolin-k-and-red-pigments-in-monascus-ruber-by-activating-mokh-and-moka-and-by-accelerating-camp-pka-pathway
#19
Jing Huang, NanQing Liao, HaoMing Li
Monacolin K, an inhibitor of HMG-CoA reductase, is a secondary metabolite synthesized by polyketide synthases (PKS) from Monascus ruber. The mokH gene encoding Zn(II)2Cys6 binding protein and mokA gene encoding polyketide synthase are presumed to activate monacolin K production. In this study, linoleic acid could be a quorum sensing signaling molecule to increase monacolin K production in the cyclic AMP(cAMP)-protein kinase A(PKA) signaling pathway. Analysis of the PKA activity and the cAMP concentration shows that linoleic acid could increase cAMP concentration and activate PKA...
November 18, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29162369/carney-complex-review-genetic-features
#20
María Belén Bosco Schamun, Ricardo Correa, Patricia Graffigna, Valeria de Miguel, Patricia Fainstein Day
Carney complex is a multiple neoplasia syndrome having endocrine and non-endocrine manifestations. Diagnostic criteria include myxoma, lentigines, and primary pigmented nodular adrenocortical disease, amongst other signs/symptoms. In most cases it is an autosomal dominant disease, and diagnosis therefore requires study and follow-up of the family members. Inactivating mutations of the PRKAR1A gene were identified as the main cause of the disease, although since 2015 other disease-related genes, including PRKACA and PRKACB activating mutations, have also been related with Carney complex...
November 18, 2017: Endocrinología, diabetes y nutrición
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