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https://www.readbyqxmd.com/read/28241322/three-dimensional-analysis-of-morphologic-changes-and-visual-outcomes-in-neovascular-age-related-macular-degeneration
#1
Hyungwoo Lee, Aerin Jo, Hyung Chan Kim
Purpose: To investigate the association of three-dimensionally quantified lesions with best-corrected visual acuity (BCVA) in typical neovascular age-related macular degeneration (nAMD). Methods: We retrospectively analyzed 65 eyes of 61 typical nAMD patients. Lesions at baseline and month 12 were manually delineated in optical coherence tomography. The volume of intraretinal fluid (IRF), subretinal fluid (SRF), subretinal hyperreflective material (SHRM), and pigment epithelial detachment (PED) were measured...
February 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28241319/integration-of-subretinal-suspension-transplants-of-human-embryonic-stem-cell-derived-retinal-pigment-epithelial-cells-in-a-large-eyed-model-of-geographic-atrophy
#2
Sandra Petrus-Reurer, Hammurabi Bartuma, Monica Aronsson, Sofie Westman, Fredrik Lanner, Helder André, Anders Kvanta
Purpose: Subretinal suspension transplants of human embryonic stem cell-derived retinal pigment epithelial cells (hESC-RPE) have the capacity to form functional monolayers in naive eyes. We explore hESC-RPE integration when transplanted in suspension to a large-eyed model of geographic atrophy (GA). Methods: Derivation of hESC-RPE was performed in a xeno-free and defined manner. Subretinal bleb injection of PBS or sodium iodate (NaIO3) was used to induce a GA-like phenotype...
February 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28241314/retinal-pigment-epithelial-cells-suppress-phagolysosome-activation-in-macrophages
#3
Eric Wang, Yoona Choe, Tat Fong Ng, Andrew W Taylor
Purpose: The eye is an immune-privileged microenvironment that has adapted several mechanisms of immune regulation to prevent inflammation. One of these potential mechanisms is retinal pigment epithelial cells (RPE) altering phagocytosis in macrophages. Methods: The conditioned media of RPE eyecups from eyes of healthy mice and mice with experimental autoimmune uveitis (EAU) were used to treat primary macrophage phagocytizing pHrodo bacterial bioparticles. In addition, the neuropeptides were depleted from the conditioned media of healthy RPE eyecups and used to treat phagocytizing macrophages...
February 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28241021/extracellular-vesicles-mediate-signaling-between-the-aqueous-humor-producing-and-draining-cells-in-the-ocular-system
#4
Natalie Lerner, Sofia Avissar, Elie Beit-Yannai
PURPOSE: Canonical Wnt signaling is associated with glaucoma pathogenesis and intraocular pressure (IOP) regulation. Our goal was to gain insight into the influence of non-pigmented ciliary epithelium (NPCE)-derived exosomes on Wnt signaling by trabecular meshwork (TM) cells. The potential impact of exosomes on Wnt signaling in the ocular drainage system remains poorly understood. METHODS: Exosomes isolated from media collected from cultured NPCE cells by differential ultracentrifugation were characterized by dynamic light scattering (DLS), tunable resistive pulse sensing (TRPS), and nanoparticle tracking analysis (NTA), sucrose density gradient migration and transmission electron microscopy (TEM)...
2017: PloS One
https://www.readbyqxmd.com/read/28240948/comparison-of-indocyanine-green-and-sodium-fluorescein-for-anterior-segment-angiography-of-ophthalmically-normal-eyes-of-goats-sheep-and-alpacas-performed-with-a-digital-single-lens-reflex-camera-adaptor
#5
Alexander J LoPinto, Chris G Pirie, Sandra L Ayres, Daniela Bedenice
OBJECTIVE To compare results of anterior segment angiography of ophthalmically normal eyes of goats, sheep, and alpacas performed by use of indocyanine green (ICG) and sodium fluorescein (SF). ANIMALS 10 female goats (mean ± SD age, 6.8 ± 1.7 years), 10 female sheep (3.0 ± 2.2 years), and 10 alpacas (7 females and 3 males; 6.8 ± 3.8 years). PROCEDURES A catheter was aseptically placed into a jugular vein. Each animal was anesthetized and properly positioned, and 0.25% ICG was administered. Images were obtained by use of an adaptor system consisting of a modified digital single-lens reflex camera, camera adaptor, and camera lens...
March 2017: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/28240677/an-unusual-cause-of-myelopathy-ochronotic-spondyloarthropathy-with-positive-hla-b27
#6
Sinem Bozkurt, Lale Aktekin, Fatma Gülçin Uğurlu, Serdar Balci, Nebahat Sezer, Selami Akkus
Ochronosis is a late developing complication of alkaptonuria, a black brownish pigment in the fibrous and cartilaginous tissues. Although most previous studies reported alkaptonuria and back pain due to ochronosis, thoracic myelopathy is an extremely rare complication. In this report, a paraparetic patient who has ochronotic spondiloarthropathy with the presence of HLA B27 antigen is described. He had low back and leg pain and morning stiffness for 5 yrs. Last year, these were followed by tingling, numbness, and weakness the in lower extremities and he was operated on with preliminary diagnosis of prolapsed disc herniation and cord compression...
February 24, 2017: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/28240407/the-significance-of-blue-color-in-dermatoscopy
#7
Mirjana Popadic, Christoph Sinz, Harald Kittler
BACKGROUND AND OBJECTIVES: Skin lesions with blue color are frequently excised to rule out malignancy. The objective of the present study was to investigate the significance of blue color. METHODS: We retrospectively scanned dermatoscopic images for blue color and classified them according to pattern analysis. RESULTS: Of 1,123 pigmented skin lesions, 144 (12.8 %) showed blue color, 92 of which (63.9 %) were malignant. Among lesions with blue color, the most common benign diagnoses were nevi (n = 35, 24...
February 27, 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/28240347/efficacy-of-smartphone-applications-in-high-risk-pigmented-lesions
#8
Alexander Ngoo, Anna Finnane, Erin McMeniman, Jean-Marie Tan, Monika Janda, H Peter Soyer
BACKGROUND/OBJECTIVES: Melanoma apps are smartphone applications that assess risk of pigmented lesions using a smartphone camera and underlying algorithm. We aimed to assess the capability of melanoma smartphone applications (apps) in making clinical decisions about risk, compared with lesion assessment by specialist trained dermatologists. METHODS: A prospective study of 3 melanoma apps was conducted between 2015 and 2016, recruiting 30 patients with 57 pigmented lesions...
February 27, 2017: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/28240335/dnp-enhanced-ultrawideline-207-pb-solid-state-nmr-spectroscopy-an-application-to-cultural-heritage-science
#9
Takeshi Kobayashi, Frédéric A Perras, Anna Murphy, Yao Yao, Jaclyn Catalano, Silvia A Centeno, Cecil Dybowski, Nicholas Zumbulyadis, Marek Pruski
Dynamic nuclear polarization (DNP) is used to enhance the (ultra)wideline (207)Pb solid-state NMR spectra of lead compounds of relevance in the preservation of cultural heritage objects. The DNP SSNMR experiments enabled, for the first time, the detection of the basic lead carbonate phase of the lead white pigment by (207)Pb SSNMR spectroscopy. Variable-temperature experiments revealed that the short T'2 relaxation time of the basic lead carbonate phase hinders the acquisition of the NMR signal at room temperature...
February 27, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28240252/novel-quantitative-pigmentation-phenotyping-enhances-genetic-association-epistasis-and-prediction-of-human-eye-colour
#10
Andreas Wollstein, Susan Walsh, Fan Liu, Usha Chakravarthy, Mati Rahu, Johan H Seland, Gisèle Soubrane, Laura Tomazzoli, Fotis Topouzis, Johannes R Vingerling, Jesus Vioque, Stefan Böhringer, Astrid E Fletcher, Manfred Kayser
Success of genetic association and the prediction of phenotypic traits from DNA are known to depend on the accuracy of phenotype characterization, amongst other parameters. To overcome limitations in the characterization of human iris pigmentation, we introduce a fully automated approach that specifies the areal proportions proposed to represent differing pigmentation types, such as pheomelanin, eumelanin, and non-pigmented areas within the iris. We demonstrate the utility of this approach using high-resolution digital eye imagery and genotype data from 12 selected SNPs from over 3000 European samples of seven populations that are part of the EUREYE study...
February 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28239787/heterogeneity-of-retinal-pigment-epithelial-cells-from-adult-human-eye-in-different-culturing-systems
#11
A V Kuznetsova, M A Aleksandrova
We studied the behavior of retinal pigment epithelial cells from adult human eye derived from different donors in different culturing systems: on plastic, in collagen gel, and on decellularized neural retina substrate. The cells diverge into two subpopulations similar by their morphology and behavior: one subpopulation migrated to the surface of the dense substrate and the other formed spheroid structures consisting of aggregated cells. This fact confirms the data on genetically-predetermined phenotypic heterogeneity of retinal pigment epithelium cells that should be taken into account when using these cells in tissue engineering...
February 27, 2017: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28239774/change-of-monascus-pigment-metabolism-and-secretion-in-different-extractive-fermentation-process
#12
Gong Chen, Rui Tang, Xiaofei Tian, Peng Qin, Zhenqiang Wu
Monascus pigments that were generally produced intracellularly from Monascus spp. are important natural colorants in food industry. In this study, change of pigment metabolism and secretion was investigated through fed-batch extractive fermentation and continuous extractive fermentation. The biomass, secreting rate of pigment and total pigment yield closely correlated with the activated time of extractive fermentation as well as the composition of feeding nutrients. Metal ions played a key role in both the cell growth and pigment metabolism...
February 26, 2017: Bioprocess and Biosystems Engineering
https://www.readbyqxmd.com/read/28239662/zika-virus-infects-cells-lining-the-blood-retinal-barrier-and-causes-chorioretinal-atrophy-in-mouse-eyes
#13
Pawan Kumar Singh, John-Michael Guest, Mamta Kanwar, Joseph Boss, Nan Gao, Mark S Juzych, Gary W Abrams, Fu-Shin Yu, Ashok Kumar
Zika virus (ZIKV) is an important pathogen that causes not only neurologic, but also ocular, abnormalities. Thus, it is imperative that models to study ZIKV pathogenesis in the eye are developed to identify potential targets for interventions. Here, we studied ZIKV interactions with human retinal cells and evaluated ZIKV's pathobiology in mouse eyes. We showed that cells lining the blood-retinal barrier (BRB), the retinal endothelium, and retinal pigment epithelium (RPE) were highly permissive and susceptible to ZIKV-induced cell death...
February 23, 2017: JCI Insight
https://www.readbyqxmd.com/read/28238662/coordination-by-cdc42-of-actin-contractility-and-adhesion-for-melanoblast-movement-in-mouse-skin
#14
Emma F Woodham, Nikki R Paul, Benjamin Tyrrell, Heather J Spence, Karthic Swaminathan, Michelle R Scribner, Evangelos Giampazolias, Ann Hedley, William Clark, Frieda Kage, Daniel J Marston, Klaus M Hahn, Stephen W G Tait, Lionel Larue, Cord H Brakebusch, Robert H Insall, Laura M Machesky
The individual molecular pathways downstream of Cdc42, Rac, and Rho GTPases are well documented, but we know surprisingly little about how these pathways are coordinated when cells move in a complex environment in vivo. In the developing embryo, melanoblasts originating from the neural crest must traverse the dermis to reach the epidermis of the skin and hair follicles. We previously established that Rac1 signals via Scar/WAVE and Arp2/3 to effect pseudopod extension and migration of melanoblasts in skin...
February 18, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28238461/-increased-glucose-uptake-by-seborrheic-keratosis-on-pet-scan
#15
C Merklen-Djafri, P Truntzer, S Hassler, B Cribier
BACKGROUND: Positron emission tomography (PET) is an examination based upon the uptake of a radioactive tracer by hypermetabolic cells. It is primarily used in tandem with tomodensitometry (PET-TDM) for cancer staging because of its high sensitivity and specificity for the detection of metastases. However, unusually high uptake may occur with benign tumours, including skin tumours. Herein, we report an extremely rare case of pathological uptake levels resulting from seborrhoeic keratosis...
February 23, 2017: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/28238097/igf-1-mediated-survival-from-induced-death-of-human-primary-cultured-retinal-pigment-epithelial-cells-is-mediated-by-an-akt-dependent-signaling-pathway
#16
Wenhua Zheng, Qian Meng, Haitao Wang, Fengxia Yan, Peter J Little, Xinguo Deng, Shaofen Lin
Degeneration of the human retinal pigmented epithelium (hRPE) is involved in several eye disorders such as age-related macular degeneration (AMD). In this study, we investigated the protective effect of IGF-1 on human primary cultured RPE cells and its underlying mechanism. IGF-1 dose- and time-dependently promoted the survival of RPE cells from serum deprivation. Western blot showed that IGF-1 stimulated the activation of the PI3K/Akt and MAPK pathways in hRPE. Inhibition of the PI3K/Akt pathway by the PI3K-specific inhibitor, LY294002 or inhibition of Akt by Akt-specific inhibitors Akt inhibitor VIII or SN-38, or downregulation Akt with siRNA specific for Akt blocked the effect of IGF-1 on hRPE...
February 25, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28237997/umtco1-a-hybrid-histidine-kinase-gene-is-essential-for-the-sexual-development-and-virulence-of-ustilago-maydis
#17
Yeo Hong Yun, Man Hwan Oh, Jun Young Kim, Seong Hwan Kim
Hybrid histidine kinase is a part of two-component system that is required for various stress responses and pathogenesis of pathogenic fungi. The Tco1 gene in human pathogen Cryptococcus neoformans encodes a hybrid histidine kinase and is important for pathogenesis. In the present study, we identified a Tco1 gene homolog, UmTco1, in the corn smut pathogen Ustilago maydis by bioinformatics analysis. To explore the role of UmTco1 in the survival of U. maydis under environmental stresses and its pathogenesis, Δumtco1 mutants were constructed by allelic exchange...
February 24, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28237771/-primary-intramedullary-melanoma-case-report-and-literature-review
#18
Yislenz Narváez-Martínez, Napoleón de la Ossa, Raquel López-Martos, Carlos Cohn-Reinoso, Marina Castellví-Juan, Secundino Martin-Ferrer
A dark pigmented intramedullary mass is very rarely encountered in daily practice, and poses a diagnostic challenge. Several entities have to be considered, including melanin-containing tumours (melanotic ependymoma and melanotic schwannoma) and melanocyte-containing tumours (melanocytoma, primary melanoma and melanoma metastases). The case is presented of a 47 year-old male with a pigmented intramedullary tumour located at T7-T8 level. Magnetic resonance images (MRI) revealed a tumour with hyperintensity on T1 and hypointensity on T2...
February 22, 2017: Neurocirugía
https://www.readbyqxmd.com/read/28236829/seasonal-variation-of-eutrophication-in-some-lakes-of-danube-delta-biosphere-reserve
#19
Liliana Török, Zsolt Török, Elfrida M Carstea, Dan Savastru
  To understand the trophic state of lakes, this study aims to determine the dynamics of phytoplankton assemblages and the main factors that influence their seasonal variation. Sampling campaigns were carried out in three lakes from the Danube Delta Biosphere Reserve. Spectral analysis of specific phytoplankton pigments was applied as a diagnostic marker to establish the distribution and composition of phytoplankton taxonomic groups. Fluorescence spectroscopy was used to quantify changes in dissolved organic matter (DOM)...
January 1, 2017: Water Environment Research: a Research Publication of the Water Environment Federation
https://www.readbyqxmd.com/read/28236620/influence-of-huang-lian-jie-du-decoction-on-quorum-sensing-system-of-pseudomonas-aeruginosa
#20
Fei Xia, Lihua Ye, Ping Wang, Mingwei Zhang
Context • Pseudomonas aeruginosa (P aeruginosa) is an opportunistic and nosocomial, Gram-negative pathogen that is characteristic of quorum sensing (QS) modulation. QS inhibition (QSI) is considered to be a new approach to antimicrobial treatment that may reduce issues of antibiotic resistance. Traditional Chinese herbs have been recognized as a source of QSI. Objective • This study was intended to investigate whether the Huang Lian Jie Du decoction (HLJJD) possesses the ability to produce anti-QS activity...
February 27, 2017: Alternative Therapies in Health and Medicine
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