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https://www.readbyqxmd.com/read/28654630/prognostic-value-of-subretinal-hyperreflective-material-in-neovascular-age-related-macular-degeneration-treated-with-bevacizumab
#1
Russell Pokroy, Michael Mimouni, Edward Barayev, Fani Segev, Noa Geffen, Arie Y Nemet, Ori Segal
PURPOSE: To study the correlation between subretinal hyperreflective material (SHRM) seen on spectral domain optical coherence tomography at baseline and visual outcomes after intravitreal bevacizumab injection in neovascular age-related macular degeneration. METHODS: Consecutive patient charts with treatment-naive center-involved neovascular age-related macular degeneration treated with 3 monthly intravitreal bevacizumab's, continued as needed, from 2011 to 2014 were reviewed...
June 20, 2017: Retina
https://www.readbyqxmd.com/read/28654629/predictors-of-one-year-visual-outcomes-after-anti-vascular-endothelial-growth-factor-treatment-for-neovascular-age-related-macular-degeneration
#2
Laurent Kodjikian, Evelyne Decullier, Eric H Souied, Adeline Roux, Gilles Aulagner, Laure Huot
PURPOSE: To determine predictors of best-corrected visual acuity (BCVA) outcomes 1 year after ranibizumab or bevacizumab treatment for neovascular age-related macular degeneration, within the French Study Group Avastin versus Lucentis for neovascular age-related macular degeneration (GEFAL). METHODS: Patients aged ≥50 years presenting subfoveal neovascular age-related macular degeneration were randomized to receive ranibizumab or bevacizumab (3 monthly intravitreal injections followed by an as-needed regimen)...
June 20, 2017: Retina
https://www.readbyqxmd.com/read/28654333/identification-of-genes-for-synthesis-of-the-blue-pigment-biliverdin-ix%C3%AE-in-the-blue-coral-heliopora-coerulea
#3
Yuki Hongo, Nina Yasuda, Satoshi NagaI
Heliopora coerulea is the only species in the subclass Octocorallia that has a crystalline aragonite skeleton. The skeleton has been reported to contain the blue pigment, biliverdin IXα, which is formed by heme oxygenase (HO) during heme decomposition. There is little information regarding gene expression in H. coerulea; therefore, the biosynthesis pathway for biliverdin IXα is poorly understood. To identify the genes related to heme synthesis and degradation, metatranscripts of H. coerulea and its symbiont Symbiodinium spp...
April 2017: Biological Bulletin
https://www.readbyqxmd.com/read/28654331/effects-of-temperature-and-pco2-on-population-regulation-of-symbiodinium-spp-in-a-tropical-reef-coral
#4
Garen Baghdasarian, Andrew Osberg, Danielle Mihora, Hollie Putnam, Ruth D Gates, Peter J Edmunds
This study tested the bleaching response of the Pacific coral Seriatopora caliendrum to short-term exposure to high temperature and elevated partial pressure of carbon dioxide (pCO2). Juvenile colonies collected from Nanwan Bay, Taiwan, were used in a factorial experimental design in which 2 temperatures (∼27.6 °C and ∼30.4 °C) and 2 pCO2 values (∼47.2 Pa and ∼90.7 Pa) were crossed to evaluate, over 12 days, the effects on the densities and physiology of the symbiotic dinoflagellates (Symbiodinium) in the corals...
April 2017: Biological Bulletin
https://www.readbyqxmd.com/read/28653895/cancer-risk-in-patients-with-peutz-jeghers-syndrome-a-retrospective-cohort-study-of-336-cases
#5
Hong-Yu Chen, Xiao-Wei Jin, Bai-Rong Li, Ming Zhu, Jing Li, Gao-Ping Mao, Ya-Fei Zhang, Shou-Bin Ning
Peutz-Jeghers syndrome is a rare autosomal dominant inherited disorder characterized by mucocutaneous pigmentation and hamartomatous gastrointestinal polyposis. A growing body of evidence has shown that Peutz-Jeghers syndrome could cause an increased risk of various cancers, yet the range of cancer risk estimates was wide among different studies. In this retrospective cohort study, 336 patients with Peutz-Jeghers syndrome in China were enrolled. The clinical characteristics, cancer spectrum, relative cancer risks, and cumulative cancer risks were analyzed...
June 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28653414/three-new-species-of-curimatopsis-characiformes-curimatidae-from-the-amazon-basin
#6
B F Melo, C Oliveira
Three new species of Curimatopsis are described from major tributaries of the Amazon basin. Curimatopsis guaporensis n. sp., from the Rio Madeira, belongs to the Curimatopsis evelynae clade and can be distinguished by the distinctive shape of the dark blotch on the caudal peduncle and by the position and shape of the nostrils. Curimatopsis pallida n. sp., from the Rio Negro, also related to C. evelynae, is distinguished from all congeners by the complete absence of pigmentation on the lateral surface of the caudal peduncle...
June 27, 2017: Journal of Fish Biology
https://www.readbyqxmd.com/read/28652902/efficacy-of-conventional-laser-irradiation-versus-a-new-method-for-gingival-depigmentation-sieve-method-a-clinical-trial
#7
Behzad Houshmand, Noushin Janbakhsh, Fatemeh Khalilian, Mohammad Reza Talebi Ardakani
Introduction: Diode laser irradiation has recently shown promising results for treatment of gingival pigmentation. This study sought to compare the efficacy of 2 diode laser irradiation protocols for treatment of gingival pigmentations, namely the conventional method and the sieve method. Methods: In this split-mouth clinical trial, 15 patients with gingival pigmentation were selected and their pigmentation intensity was determined using Dummett's oral pigmentation index (DOPI) in different dental regions. Diode laser (980 nm wavelength and 2 W power) was irradiated through a stipple pattern (sieve method) and conventionally in the other side of the mouth...
2017: Journal of Lasers in Medical Sciences
https://www.readbyqxmd.com/read/28652262/identification-and-metabolite-profiling-of-chemical-activators-of-lipid-accumulation-in-green-algae
#8
Nishikant Wase, Boqiang Tu, James W Allen, Paul N Black, Concetta C DiRusso
Microalgae are proposed as feedstock organisms useful for producing biofuels and co-products. However, several limitations must be overcome before algae-based production is economically feasible. Among these is the ability to induce lipid accumulation and storage without affecting biomass yield. To overcome this barrier, a chemical genetics approach was employed in which 43,783 compounds were screened against Chlamydomonas reinhardtii and 243 compounds were identified that increase triacylglyceride (TAG) accumulation without terminating growth...
June 26, 2017: Plant Physiology
https://www.readbyqxmd.com/read/28652100/current-role-for-radioisotope-synovectomy
#9
Vincent André, Vincent Dalibard, Emmanuelle Dernis, Stéphane Varin, Grégoire Cormier
Radioisotope synovectomy has been extensively used to treat patients with chronic inflammatory joint disease but has moved to a less prominent position since the introduction of new and highly effective drugs. Remaining indications are refractory synovitis, pigmented villonodular synovitis as an adjunct to surgery, and hemophilic arthropathy. The three main radioisotopes used are yttrium-90, rhenium-186, and erbium-189. Radioisotope synovectomy should be performed only by highly experienced professionals, to minimize the risk of injection-related complications...
June 23, 2017: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/28652051/the-visual-system-in-infants-with-microcephaly-related-to-presumed-congenital-zika-syndrome
#10
Islane Verçosa, Paula Carneiro, Reno Verçosa, Renata Girão, Erlane M Ribeiro, Andre Pessoa, Nadia G Almeida, Paloma Verçosa, Marcia B Tartarella
PURPOSE: To describe and analyze ocular features in infants with microcephaly due to presumed congenital Zika syndrome. METHODS: Ophthalmologic evaluation, including indirect ophthalmoscopy and eye fundus imaging, visual acuity testing with Teller Acuity Cards, and strabismus assessment were performed in infants with microcephaly at a nongovernmental organization clinic for visually disabled children. RESULTS: A total of 70 infants with microcephaly were referred to the clinic...
June 23, 2017: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/28651974/variants-of-ppulcc-a-multi-dye-decolorizing-laccase-from-pleurotus-pulmonarius-expressed-in-pichia-pastoris
#11
Christoph J Behrens, Diana Linke, Aldrige B Allister, Katerina Zelena, Ralf G Berger
A laccase of the basidiomycete Pleurotus pulmonarius (PpuLcc) possessed strong decolorizing abilities towards artificial and natural dyes. The PpuLcc was purified from the culture supernatant via FPLC, and the corresponding gene cloned and expressed in Pichia pastoris GS115. To examine the impact of the C-terminal tail region and the signal peptide on the recombinant expression of PpuLcc, a non-modified version or different truncations (2, -5, -13 AA) of the target protein were combined with different secretion signals...
June 23, 2017: Protein Expression and Purification
https://www.readbyqxmd.com/read/28651383/rising-temperature-stimulates-the-biosynthesis-of-water-soluble-fluorescent-yellow-pigments-and-gene-expression-in-monascus-ruber-cgmcc10910
#12
Tao Huang, Hailing Tan, Gong Chen, Lu Wang, Zhenqiang Wu
Monascus species can produce secondary metabolites that have a polyketide structure. In this study, four types of extracellular water-soluble yellow pigments (Y1-Y4) were generated by submerged fermentation with Monascus ruber CGMCC 10910, of which Y3 and Y4 had strong yellow fluorescence. The composition of the pigment mixtures was closely related to the fermentation temperature. The dominating pigments changed from Y1 to Y3 and Y4 when fermentation temperature increased from 30 to 35 °C. Increasing the temperature to 35 °C changed the metabolic pathways of the pigments, which inhibited the biosynthesis of Y1 and enhanced the biosynthesis of Y3 and Y4...
December 2017: AMB Express
https://www.readbyqxmd.com/read/28651197/ascorbic-acid-protects-coccomyxa-subellipsoidea-against-metal-toxicity-through-modulation-of-ros-no-balance-and-metal-uptake
#13
Jozef Kováčik, Gabriela Rotková, Marek Bujdoš, Petr Babula, Viera Peterková, Peter Matúš
Impact of exogenous ascorbic acid (AsA, 100μM) on acute metal toxicity (Pb and Hg, 24h of exposure to 100μM) in unicellular green alga Coccomyxa subellipsoidea was studied. Hg (often extensively) depleted amount of pigments, potassium, soluble proteins, endogenous AsA, non-protein thiols and nitric oxide signal but elevated ROS signal and activities of catalase and superoxide dismutase. Responses to Pb application (if any) were less visible with ROS signal being slightly elevated and amount of non-protein thiols being slightly reduced...
June 16, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28651176/forensic-applications-of-direct-analysis-in-real-time-dart-coupled-to-q-orbitrap-tandem-mass-spectrometry-for-the-in-situ-analysis-of-pigments-from-paint-evidence
#14
Tai-Hung Chen, Shu-Pao Wu
The accurate examination of paint fragments obtained from an accident, such as those obtained from vehicles involved in a hit-and-run case, is often critical in forensic investigations. However, organic pigments are typically minor components of automotive coatings, which makes discrimination difficult. In this study, direct analysis in real time coupled to Q-orbitrap tandem mass spectrometry (DART-MS) was employed to detect a wide range of common organic pigments in vehicle paints. Twelve common organic pigments used in vehicle paints, such as red, yellow, orange, and purple, were tested, and a database was constructed for future examinations of vehicle paint...
June 9, 2017: Forensic Science International
https://www.readbyqxmd.com/read/28649257/mati-a-novel-protein-involved-in-the-regulation-of-herbivore-associated-signaling-pathways
#15
M Estrella Santamaría, Manuel Martinez, Ana Arnaiz, Félix Ortego, Vojislava Grbic, Isabel Diaz
The defense response of the plants against herbivores relies on a complex network of interconnected signaling pathways. In this work, we characterized a new key player in the response of Arabidopsis against the two-spotted spider mite Tetranychus urticae, the MATI (Mite Attack Triggered Immunity) gene. This gene was differentially induced in resistant Bla-2 strain relative to susceptible Kon Arabidopsis accessions after mite attack, suggesting a potential role in the control of spider mites. To study the MATI gene function, it has been performed a deep molecular characterization of the gene combined with feeding bioassays using modified Arabidopsis lines and phytophagous arthropods...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28649198/the-role-of-retinal-carotenoids-and-age-on-neuroelectric-indices-of-attentional-control-among-early-to-middle-aged-adults
#16
Anne M Walk, Caitlyn G Edwards, Nicholas W Baumgartner, Morgan R Chojnacki, Alicia R Covello, Ginger E Reeser, Billy R Hammond, Lisa M Renzi-Hammond, Naiman A Khan
One apparent consequence of aging appears to be loss of some aspects of cognitive control. This loss is measurable as early as mid-adulthood. Since, like many aspects of cognition, there is wide variance among individuals, it is possible that behavior, such as one's diet, could drive some of these differences. For instance, past data on older humans and non-human primates have suggested that dietary carotenoids could slow cognitive decline. In this study, we tested how early such protection might manifest by examining a sample (n = 60) of 25-45 year olds...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28648937/the-correlation-of-the-standard-5-probe-fish-assay-with-melanocytic-tumors-of-uncertain-malignant-potential
#17
Aaron Muhlbauer, Shabnam Momtahen, Martin C Mihm, James Wang, Cynthia M Magro
BACKGROUND: FISH has recently emerged as a technique to better assess the malignant potential of histologically ambiguous melanocytic lesions. However, the usefulness of FISH has not been conclusively established. The purpose of this study was to further explore the diagnostic value of FISH in distinguishing the borderline melanocytic tumor (BMT) from melanoma. METHOD: 73 cases with BMT were analyzed retrospectively from a dermatopathology database between 2010-2015...
June 2017: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/28648894/compositional-analysis-of-endogenous-porphyrins-from-helicobacter-pylori
#18
A Battisti, P Morici, G Signore, F Ghetti, A Sgarbossa
Bacteria able to accumulate porphyrins can be inactivated by visible light irradiation thanks to the photosensitizing properties of this class of aromatic pigments (photodynamic therapy, PDT). Since the bacterial resistance to antibiotic is growing, PDT is becoming a valid alternative. In this context, the pathogen Helicobacter pylori (Hp) is a suitable target for PDT since it spontaneously produces and accumulates porphyrins. It is then important to understand the spectroscopic behavior of these endogenous species to exploit them as photosensitizers, thus improving the results given by the application of PDT in the treatment of Hp infections...
June 19, 2017: Biophysical Chemistry
https://www.readbyqxmd.com/read/28648816/how-light-affects-the-life-of-botrytis
#19
REVIEW
Julia Schumacher
Fungi, like other organisms, actively sense the environmental light conditions in order to drive adaptive responses, including protective mechanisms against the light-associated stresses, and to regulate development. Ecological niches are characterized by different light regimes, for instance light is absent underground, and light spectra from the sunlight are changed underwater or under the canopy of foliage due to the absorption of distinct wavelengths by bacterial, algal and plant pigments. Considering the fact that fungi have evolved to adapt to their habitats, the complexities of their 'visual' systems may vary significantly...
June 22, 2017: Fungal Genetics and Biology: FG & B
https://www.readbyqxmd.com/read/28648555/comparison-of-plasma-pigment-epithelium-derived-factor-pedf-retinol-binding-protein-4-rbp-4-chitinase-3-like-protein-1-ykl-40-and-brain-derived-neurotrophic-factor-bdnf-for-the-identification-of-insulin-resistance
#20
F J K Toloza, M C Pérez-Matos, M L Ricardo-Silgado, M C Morales-Álvarez, J O Mantilla-Rivas, J A Pinzón-Cortés, M Pérez-Mayorga, M L Arévalo-García, G Tolosa-González, C O Mendivil
AIMS: To evaluate and compare the association of four potential insulin resistance (IR) biomarkers (pigment-epithelium-derived factor [PEDF], retinol-binding-protein-4 [RBP-4], chitinase-3-like protein 1 [YKL-40] and brain-derived neurotrophic factor [BDNF]) with objective measures of IR. METHODS: We studied 81 subjects with different metabolic profiles. All participants underwent a 5-point OGTT with calculation of multiple IR indexes. A subgroup of 21 participants additionally underwent a hyperinsulinemic-euglycemic clamp...
June 9, 2017: Journal of Diabetes and its Complications
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