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https://www.readbyqxmd.com/read/28938016/a-feed-forward-regulation-of-endothelin-receptors-by-c-jun-in-human-non-pigmented-ciliary-epithelial-cells-and-retinal-ganglion-cells
#1
Junming Wang, Hai-Ying Ma, Raghu R Krishnamoorthy, Thomas Yorio, Shaoqing He
c-Jun, c-Jun N-terminal kinase(JNK) and endothelin B (ETB) receptor have been shown to contribute to the pathogenesis of glaucoma. Previously, we reported that an increase of c-Jun and CCAAT/enhancer binding protein β (C/EBPβ) immunohistostaining is associated with upregulation of the ETB receptor within the ganglion cell layer of rats with elevated intraocular pressure (IOP). In addition, both transcription factors regulate the expression of the ETB receptor in human non-pigmented ciliary epithelial cells (HNPE)...
2017: PloS One
https://www.readbyqxmd.com/read/28937872/protective-effect-of-combined-caffeic-acid-phenethyl-ester-and-bevacizumab-against-hydrogen-peroxide-induced-oxidative-stress-in-human-rpe-cells
#2
Erdem Dinc, Lokman Ayaz, Akif Hakan Kurt
PURPOSE: This study aimed to evaluate the protective effects of caffeic acid phenethyl ester (CAPE) and combined CAPE-bevacizumab against oxidative stress induced by hydrogen peroxide (H2O2) in human retinal pigment epithelium. METHODS: ARPE-19 cells were pretreated with 5, 10, and 30 μM CAPE alone and in combination with bevacizumab for 3 h, then exposed to H2O2 for 16 h. Cell viability was evaluated with the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay...
September 22, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28937855/eggshell-biliverdin-and-protoporphyrin-pigments-in-a-songbird-are-they-derived-from-erythrocytes-blood-plasma-or-the-shell-gland
#3
Rita Hargitai, Nóra Boross, Susanne Hámori, Eszter Neuberger, Zoltán Nyiri
Biliverdin and protoporphyrin pigments are deposited into the eggshell when the developing egg is in the shell gland. However, the site of synthesis of eggshell pigments is still uncertain, although it may influence the possible costs and potential functions of eggshell coloration in avian species. Eggshell pigments may be derived from red blood cells or be produced in other organs and then transferred to the shell gland, or they may be synthesized de novo in the shell gland. We studied in the canary (Serinus canaria) whether eggshell blue-green and brown pigmentations are associated with experimentally elevated anemia, female hematocrit level, immature erythrocyte percentage, and feces and plasma pigment levels during egg laying to find out the possible origin of eggshell pigments...
November 2017: Physiological and Biochemical Zoology: PBZ
https://www.readbyqxmd.com/read/28937825/tanshinone-iia-inhibits-vegf-secretion-and-hif-1%C3%AE-expression-in-cultured-human-retinal-pigment-epithelial-cells-under-hypoxia
#4
Rami M Alzhrani, Qasim Alhadidi, Rinda Devi Bachu, Zahoor Shah, Surajit Dey, Sai Hs Boddu
PURPOSE: The current work intends to study the activity of tanshinone IIA on secretion of vascular endothelial growth factor (VEGF) and expression of hypoxia inducible factor 1α (HIF-1α) in human retinal pigment epithelial cells (ARPE-19 cells) under hypoxic condition. METHODS: The cytotoxicity of tanshinone IIA was tested in ARPE-19 cells by MTT assay. ARPE-19 cells were incubated with different concentrations of cobalt chloride (100, 150, and 200 µM) for 12 h, and levels of expressed HIF-1α and secreted VEGF were quantified through Western blot and ELISA, respectively...
September 22, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28937525/choroidal-melanoma-in-phakomatosis-pigmentovascularis-with-klippel-trenaunay-syndrome
#5
Carol L Shields, Maura Di Nicola, Marco Pellegrini, Jerry A Shields
PURPOSE: To describe the relationship of choroidal melanoma with phakomatosis pigmentovascularis in patients with Klippel-Trenaunay syndrome. METHODS: Retrospective review of 5 patients. RESULTS: In all 5 cases, the patient was white and the cutaneous port-wine stain was congenital. The port-wine stain involved the chin (n = 1), jawline (n = 2), lower cheek (n = 1), thorax (n = 5), abdomen (n = 4), upper (n = 4), and lower (n = 3) limb(s)...
September 20, 2017: Retina
https://www.readbyqxmd.com/read/28937390/nonpigmented-strain-of-chromobacterium-violaceum-causing-neonatal-septicemia-a-rare-case-report
#6
Shreekant Tiwari, Swetalona Pattanaik, Siba Shankar Beriha
Human infection caused by Chromobacterium violaceum is rare but has got high fatality in septicemia. Nonpigmented strains of C. violaceum have been found similar in pathogenicity to pigmented strains. Pigment production is not an exclusive character of the genus Chromobacterium because around 9%-11% strains of C. violaceum are nonpigmented. Herewith, we report a nonpigmented strain of C. violaceum from a case of neonatal septicemia that was successfully treated with gentamicin plus imipenem.
July 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/28937243/relation-of-plasma-selenium-and-lipid-peroxidation-end-products-in-patients-with-alzheimer-s-disease
#7
Z Chmatalova, M Vyhnalek, J Laczo, J Hort, R Pospisilova, M Pechova, A Skoumalova
Increased oxidative stress in the brain during the course of Alzheimer's disease (AD) leads to an imbalance of antioxidants and formation of free radical reaction end-products which may be detected in blood as fluorescent lipofuscin-like pigments (LFPs). The aim of this study was to evaluate and compare LFPs with plasma selenium concentrations representing an integral part of the antioxidant system. Plasma samples from subjects with AD dementia (ADD; n=11), mild cognitive impairment (MCI; n=17) and controls (n=12), were collected...
September 22, 2017: Physiological Research
https://www.readbyqxmd.com/read/28936220/de-novo-assembly-of-the-camellia-nitidissima-transcriptome-reveals-key-genes-of-flower-pigment-biosynthesis
#8
Xingwen Zhou, Jiyuan Li, Yulin Zhu, Sui Ni, Jinling Chen, Xiaojuan Feng, Yunfeng Zhang, Shuangquan Li, Hongguang Zhu, Yuanguang Wen
The golden camellia, Camellia nitidissima Chi., is a well-known ornamental plant that is known as "the queen of camellias" because of its golden yellow flowers. The principal pigments in the flowers are carotenoids and flavonol glycosides. Understanding the biosynthesis of the golden color and its regulation is important in camellia breeding. To obtain a comprehensive understanding of flower development in C. nitidissima, a number of cDNA libraries were independently constructed during flower development. Using the Illumina Hiseq2500 platform, approximately 71...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28936145/efficacy-and-safety-of-short-pulse-erbium-yttrium-aluminum-garnet-laser-treatment-of-becker-s-nevus-in-saudi-patients-a-pilot-study
#9
Fahad Al-Saif, E Al-Mekhadab, H Al-Saif
OBJECTIVE: Becker's nevus (BN) is a benign cutaneous hamartoma. Although different types of lasers have been used to treat the pigmentary part of BN, to date, no definite treatment modality has been determined. The objective of this study is to evaluate the efficacy and safety of erbium: yttrium aluminum garnet (Er: YAG) laser treatment among Saudi patients with BN. PATIENTS AND METHODS: A series of 10 patients (skin phototypes III-V) with BN underwent treatment with an Er: YAG laser...
July 2017: International Journal of Health Sciences
https://www.readbyqxmd.com/read/28935960/combined-activation-of-map-kinase-pathway-and-%C3%AE-catenin-signaling-cause-deep-penetrating-nevi
#10
Iwei Yeh, Ursula E Lang, Emeline Durieux, Meng Kian Tee, Aparna Jorapur, A Hunter Shain, Veronique Haddad, Daniel Pissaloux, Xu Chen, Lorenzo Cerroni, Robert L Judson, Philip E LeBoit, Timothy H McCalmont, Boris C Bastian, Arnaud de la Fouchardière
Deep penetrating nevus (DPN) is characterized by enlarged, pigmented melanocytes that extend through the dermis. DPN can be difficult to distinguish from melanoma but rarely displays aggressive biological behavior. Here, we identify a combination of mutations of the β-catenin and mitogen-activated protein kinase pathways as characteristic of DPN. Mutations of the β-catenin pathway change the phenotype of a common nevus with BRAF mutation into that of DPN, with increased pigmentation, cell volume and nuclear cyclin D1 levels...
September 21, 2017: Nature Communications
https://www.readbyqxmd.com/read/28935865/melanoblast-development-coincides-with-the-late-emerging-cells-from-the-dorsal-neural-tube-in-turtle-trachemys-scripta
#11
Ritva Rice, Judith Cebra-Thomas, Maarja Haugas, Juha Partanen, David P C Rice, Scott F Gilbert
Ectothermal reptiles have internal pigmentation, which is not seen in endothermal birds and mammals. Here we show that the development of the dorsal neural tube-derived melanoblasts in turtle Trachemys scripta is regulated by similar mechanisms as in other amniotes, but significantly later in development, during the second phase of turtle trunk neural crest emigration. The development of melanoblasts coincided with a morphological change in the dorsal neural tube between stages mature G15 and G16. The melanoblasts delaminated and gathered in the carapacial staging area above the neural tube at G16, and differentiated into pigment-forming melanocytes during in vitro culture...
September 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28935841/light-and-plastid-signals-regulate-different-sets-of-genes-in-the-albino-mutant-pap7-1
#12
Björn Grübler, Livia Merendino, Sven O Twardziok, Morgane Mininno, Guillaume Allorent, Fabien Chevalier, Monique Liebers, Robert Blanvillain, Klaus Mayer, Silva Lerbs-Mache, Stephane Ravanel, Thomas Pfannschmidt
Plants possessing dysfunctional plastids due to defects in pigment biosynthesis or translation are known to repress photosynthesis-associated nuclear genes (PhANGs) via retrograde signals from the disturbed organelles towards the nucleus. These signals are thought to be essential for proper biogenesis and function of the plastid. Mutants lacking plastid-encoded RNA polymerase-associated proteins (PAPs) display a genetic arrest in eoplast-chloroplast transition leading to an albino phenotype in the light. Retrograde signaling in these mutants, thus, could be expected to be similar as under conditions inducing plastid dysfunction...
September 21, 2017: Plant Physiology
https://www.readbyqxmd.com/read/28934913/flavonoid-compounds-related-to-seed-coat-color-of-wheat
#13
Noriko Kohyama, Makiko Chono, Hiroyuki Nakagawa, Yosuke Matsuo, Hiroshi Ono, Hitoshi Matsunaka
In red wheat, reddish-brown pigments accumulate in testa of mature seeds. Half-cut wheat seeds were immersed in p-dimethylaminocinnamaldehyde (DMACA) reagent that stains flavanol structures blue. Testa of 10-40 days after flowering (DAF) in red wheat ("Norin 61" and "Satonosora") seeds were stained blue and the reagent color changed to blue with 10-25 DAF seeds. No blue staining was observed in white wheat ("Tamaizumi") seeds during maturation. "Norin 61" seed coats at 10 DAF contained dihydroquercetin, dihydromyricetin, (+)-catechin, procyanidin B3, and prodelphinidin B3, which were identified by HPLC-diode array detector and LC-MS/MS analyses...
September 22, 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/28934655/nano-sized-emission-from-commercially-available-paints-used-for-indoor-surfaces-during-drying
#14
Rikke Bramming Jørgensen, Ingrid Grav Hveding, Karoline Solheim
Consumers worry about the presence of nano-particles in paints and the risk of exposure. As a result, the paint industry now omits marketing paints as containing nanoparticles. The industry claims that no nanoparticles are released into the indoor environment; this, however, has yet to be documented. In this study, the emission of nano-sized emission from four indoor paints was investigated. The emission was studied for both base and full-pigmented versions of the paints, which consisted of three water-borne acrylic paints and one solvent-borne alkyd paint...
September 8, 2017: Chemosphere
https://www.readbyqxmd.com/read/28934317/photosynthetic-epibionts-and-endobionts-of-pacific-oyster-shells-from-oyster-reefs-in-rocky-versus-mudflat-shores
#15
Laurent Barillé, Anthony Le Bris, Vona Méléder, Patrick Launeau, Marc Robin, Ioanna Louvrou, Lourenço Ribeiro
The Pacific oyster, Crassostrea gigas (Thunberg), is the main bivalve species cultivated in the world. With global warming enabling its reproduction and larval survival at higher latitudes, this species is now recognized as invasive and creates wild oyster reefs globally. In this study, the spatial distribution of photosynthetic assemblages colonizing the shells of wild C. gigas was investigated on both a large scale (two contrasting types of reefs found in mudflats and rocky areas) and a small scale (within individual shells) using a hyperspectral imager...
2017: PloS One
https://www.readbyqxmd.com/read/28933966/mobile-laser-indirect-ophthalmoscope-for-the-induction-of-choroidal-neovascularization-in-a-mouse-model
#16
Dov Weinberger, Elite Bor-Shavit, Tilda Barliya, Mor Dahbash, Opher Kinrot, Dan D Gaton, Yael Nisgav, Tami Livnat
PURPOSE: This study aims to evaluate and standardize the reliability of a mobile laser indirect ophthalmoscope in the induction of choroidal neovascularization (CNV) in a mouse model. MATERIALS & METHODS: A diode laser indirect ophthalmoscope was used to induce CNV in pigmented male C57BL/6J mice. Standardization of spot size and laser intensity was determined using different aspheric lenses with increasing laser intensities applied around the optic disc. Development of CNV was evaluated 1, 5, and 14 days post laser application using fluorescein angiography (FA), histology, and choroidal flat mounts stained for the endothelial marker CD31 and FITC-dextran...
September 21, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28933590/rubcn-rubicon-and-egfr-regulate-lysosomal-degradative-processes-in-the-retinal-pigment-epithelium-rpe-of-the-eye
#17
Luis Muniz-Feliciano, Teresa A Doggett, Zhenqing Zhou, Thomas A Ferguson
Macroautophagy/autophagy is an intracellular stress survival and recycling system whereas phagocytosis internalizes material from the extracellular milieu; yet, both pathways utilize lysosomes for cargo degradation. Whereas autophagy occurs in all cells, phagocytosis is performed by cell types such as macrophages and the retinal pigment epithelial (RPE) cells of the eye where it is supported by the noncanonical autophagy process termed LC3-associated phagocytosis (LAP). Autophagy and LAP are distinct pathways that use many of the same mediators and must compete for cellular resources, suggesting that cells may regulate both processes under homeostatic and stress conditions...
September 21, 2017: Autophagy
https://www.readbyqxmd.com/read/28933318/sphingomonas-antarctica-sp-nov-isolated-from-antarctic-tundra-soil
#18
Yao Huang, Ziyan Wei, Wangmu Danzeng, Myong Chol Kim, Guoxin Zhu, Yumin Zhang, Zuobing Liu, Fang Peng
Strain 200T, isolated from a soil sample taken from Antarctic tundra soil around Zhongshan Station, was found to be a Gram-stain-negative, yellow-pigmented, catalase-positive, oxidase-negative, non-motile, non-spore-forming, rod-shaped and aerobic bacterium. Strain 200T grew optimally at pH 7.0 and in the absence of NaCl on R2A. Its optimum growth temperature was 20 °C. Phylogenetic analysis based on 16S rRNA gene sequences indicated that strain 200T belonged to the genus Sphingomonas. Strain 200T showed the highest sequence similarities to Sphingomonas kyeonggiense THG-DT81T (95...
September 21, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28932778/data-on-the-density-of-xanthophores-in-a-whole-scale-of-goldfish-acclimated-to-white-or-black-background-color
#19
Kanta Mizusawa, Yutaka Yamamura, Satoshi Kasagi, José Miguel Cerdá-Reverter, Akiyoshi Takahashi
The data presented in this article are related to the research article entitled "Expression of genes for melanotropic peptides and their receptors for morphological color change in goldfish Carassius auratus" (Mizusawa et al., In press) [1]. This article describes data on the density of xanthophores in the scales of goldfish acclimated to white or black background color. To determine the effects of acclimation history during long-term background color adaptation, fish were transferred from a white tank to a white or black tank and vice versa halfway through the acclimation process...
October 2017: Data in Brief
https://www.readbyqxmd.com/read/28932607/percutaneous-endoscopic-management-for-oriental-cholangiohepatitis-a-case-report-and-a-brief-review-of-the-literature
#20
Khalil Aloreidi, Prince Sethi, Terry Yeager, Muslim Atiq
Oriental cholangiohepatitis (OCH) is a disease characterized by intrabiliary pigment stone formation, resulting in recurrent bouts of cholangitis. OCH is found mostly in Southeast Asia but it is occasionally recognized in Western societies. OCH etiology is largely unknown. We report our experience with a patient who presented with acute cholecystitis. Following laparoscopic cholecystectomy, she developed acute cholangitis due to multiple biliary tree stones. She underwent ERCP to clear the stones from common bile duct...
2017: Case Reports in Gastrointestinal Medicine
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