keyword
MENU ▼
Read by QxMD icon Read
search

Kyu joo park

keyword
https://www.readbyqxmd.com/read/28816139/total-mesorectal-excision-versus-local-excision-after-favorable-response-to-preoperative-chemoradiotherapy-in-early-clinical-t3-rectal-cancer-a-propensity-score-analysis
#1
Young Seob Shin, Chang Sik Yu, Jin-Hong Park, Jin Cheon Kim, Seok-Byung Lim, In Ja Park, Tae Won Kim, Yong Sang Hong, Kyu-Pyo Kim, Sang Min Yoon, Ji Hyeon Joo, Jong Hoon Kim
PURPOSE: To compare oncological outcomes of total mesorectal excision (TME) and local excision (LE) in patients with "early" clinical T3 rectal cancer who received preoperative chemoradiotherapy (PCRT). METHODS AND MATERIALS: "Early" clinical T3 rectal cancer was radiologically defined as tumors with extramural extension of <5 mm without mesorectal fascia involvement and lateral lymph node metastasis. Patients with "early" clinical T3 rectal cancer who received PCRT followed by TME or LE between January 2007 and December 2013 were retrospectively analyzed...
September 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28797465/conditional-relative-survival-of-oral-cavity-cancer-based-on-korean-central-cancer-registry
#2
Seung-Ki Min, Sung Weon Choi, Johyun Ha, Joo Yong Park, Young-Joo Won, Kyu-Won Jung
OBJECTIVES: Conditional relative survival (CRS) describes the survival chance of patients who have already survived for a certain period of time after diagnosis and treatment of cancer. Thus, CRS can complement the conventional 5-year relative survival, which does not consider the time patients have survived after their diagnosis. This study aimed to assess the 5-year CRS among Korean patients with oral cancer and the related risk factors. MATERIALS AND METHODS: We identified 15,329 oral cavity cancer cases with a diagnosis between 1993 and 2013 in the Korea Central Cancer Registry...
September 2017: Oral Oncology
https://www.readbyqxmd.com/read/28797113/clinical-outcomes-of-biodegradable-polymer-biolimus-eluting-biomatrix-stents-versus-durable-polymer-everolimus-eluting-xience-stents
#3
Da Hyon Lee, Taek Kyu Park, Young Bin Song, Woo Jung Chun, Rak Kyeong Choi, Jin-Ok Jeong, Eul Soon Im, Sang Wook Kim, Joo Myung Lee, Jeong Hoon Yang, Joo-Yong Hahn, Seung-Hyuk Choi, Jin-Ho Choi, Sang Hoon Lee, Hyeon-Cheol Gwon
There are limited data about clinical outcomes of biodegradable polymer biolimus-eluting BioMatrix stents (BP-BES) and durable polymer everolimus-eluting Xience stents (DP-EES) in real world practice. We sought to compare the clinical outcomes of BP-BES and DP-EES in real world cohorts of patients undergoing percutaneous coronary intervention. A prospective multicenter registry enrolled 999 patients treated with BP-BES and 1,000 patients treated with DP-EES. The primary outcome was target lesion failure, defined as a composite of cardiac death, target vessel-related myocardial infarction, or target lesion revascularization...
2017: PloS One
https://www.readbyqxmd.com/read/28777314/artificial-auricular-cartilage-using-silk-fibroin-and-polyvinyl-alcohol-hydrogel
#4
Jung Min Lee, Md Tipu Sultan, Soon Hee Kim, Vijay Kumar, Yeung Kyu Yeon, Ok Joo Lee, Chan Hum Park
Several methods for auricular cartilage engineering use tissue engineering techniques. However, an ideal method for engineering auricular cartilage has not been reported. To address this issue, we developed a strategy to engineer auricular cartilage using silk fibroin (SF) and polyvinyl alcohol (PVA) hydrogel. We constructed different hydrogels with various ratios of SF and PVA by using salt leaching, silicone mold casting, and freeze-thawing methods. We characterized each of the hydrogels in terms of the swelling ratio, tensile strength, pore size, thermal properties, morphologies, and chemical properties...
August 4, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28770232/the-association-between-type-2-diabetes-mellitus-and-thyroid-cancer
#5
Young-Gyun Seo, Ho-Chun Choi, Ah Reum An, Do Joon Park, Young Joo Park, Kyu Eun Lee, Sue K Park, Yunji Hwang, Belong Cho
AIM: The incidence of thyroid cancer is increasing worldwide. The prevalence of type 2 diabetes mellitus (T2DM) is also increasing. Therefore, we aimed to analyze the effect of T2DM on thyroid cancer. METHODS: A case-control study was performed. A total of 415 healthy controls with thyroid ultrasound screening and physician consultation were selected from the Thyroid Cancer Longitudinal Study (T-CALOS). Among patients with thyroid cancer who were enrolled in T-CALOS, 415 patients were matched to the control group according to age and sex...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28760197/transforming-growth-factor-%C3%AE-1-enhances-adhesion-of-endometrial-cells-to-mesothelium-by-regulating-integrin-expression
#6
Hee-Jung Choi, Mi-Ju Park, Bo-Sung Kim, Hee-Jin Choi, Bosun Joo, Kyu Sup Lee, Jung-Hye Choi, Tae-Wook Chung, Ki-Tae Ha
Interestingly, transforming growth factor β1 (TGF-β1) expression was higher in endometriotic epithelial cells than in normal endometrial cells. The adhesion efficiency of endometriotic epithelial cells to mesothelial cells was also higher than that of normal endometrial cells. Moreover, TGF-β1 directly induced the adhesion of endometrial cells to mesothelial cells through the regulation of integrin of αV, α6, β1, and β4 via the activation of the TGF-β1/TGF-βRI/Smad2 signaling pathway. Conversely, the adhesion of TGF-β1-stimulated endometrial cells to mesothelial cells was clearly reduced following treatment with neutralizing antibodies against specific TGF-β1-mediated integrins αV, β1, and β4 on the endometrial cell membrane...
August 1, 2017: BMB Reports
https://www.readbyqxmd.com/read/28760196/effects-of-pep-1-fk506bp-on-cyst-formation-in-polycystic-kidney-disease
#7
Hyo Sang Jo, Won Sik Eum, Eun Young Park, Je Young Ko, Do Yeon Kim, Dae Won Kim, Min Jea Shin, Ora Son, Su Bin Cho, Jung Hwan Park, Chi Hern Lee, Eun Ji Yeo, Hyeon Ji Yeo, Yeon Joo Choi, Jong Kyu Youn, Sung-Woo Cho, Jinseu Park, Jong Hoon Park, Soo Young Choi
Polycystic kidney disease (PKD) is one of the most common inherited disorders, whereby progressive cyst formation in the kidney leads to renal failure. FK506 binding protein 12 (FK506BP) is an immunophilin protein which performs multiple functions including regulation of cell signaling and survival. In this study, we determined the roles of PEP-1-FK506BP on cell proliferation and cyst formation in PKD cells. Purified PEP-1-FK506BP transduced into PKD cells and markedly inhibited cell proliferation. Also, PEP-1-FK506BP drastically inhibited the expression levels of p-Akt, p-p70S6K, p-mTOR, and p-ERK in PKD cells...
July 28, 2017: BMB Reports
https://www.readbyqxmd.com/read/28756020/identification-and-characterization-of-the-tyrosinase-gene-tyr-and-its-transcript-variants-tyr_1-and-tyr_2-in-the-crab-eating-macaque-macaca-fascicularis
#8
Young-Hyun Kim, Sang-Je Park, Se-Hee Choe, Ja-Rang Lee, Hyeon-Mu Cho, Sun-Uk Kim, Ji-Su Kim, Bo-Woong Sim, Bong-Seok Song, Youngjeon Lee, Yeung Bae Jin, Jung-Joo Hong, Kang-Jin Jeong, Philyong Kang, Seung-Ho Baek, Sang-Rae Lee, Jae-Won Huh, Kyu-Tae Chang
Tyrosinase is a copper-containing enzyme that regulates melanin biosynthesis and is encoded by the tyrosinase (TYR) gene. Previous studies demonstrated that mutations in TYR could lead to oculocutaneous albinism type 1 (OCA1) owing to the failure of melanin formation. Although a previous study found that albinism in the rhesus monkey was derived from a mutation in TYR, the identification and characterization of this gene in non-human primates has not been achieved thus far. Thus, using the rapid amplification of cDNA ends (RACE) and internal reverse transcription PCR (RT-PCR) we identified the full-length sequence of TYR in the crab-eating macaque, and two different transcript variants (TYR_1 and TYR_2)...
July 26, 2017: Gene
https://www.readbyqxmd.com/read/28752697/clinical-features-of-pregnancy-associated-retinal-and-choroidal-diseases-causing-acute-visual-disturbance
#9
Young Joo Park, Kyu Hyung Park, Se Joon Woo
PURPOSE: To report clinical features of patients with retinal and choroidal diseases presenting with acute visual disturbance during pregnancy. METHODS: In this retrospective case series, patients who developed acute visual loss during pregnancy (including puerperium) and visited a tertiary hospital from July 2007 to June 2015, were recruited by searching electronic medical records. Patients were categorized according to the cause of visual loss. Clinical features and required diagnostic modalities were analyzed in the retinal and choroidal disease group...
August 2017: Korean Journal of Ophthalmology: KJO
https://www.readbyqxmd.com/read/28752246/myelopathy-associated-with-instability-consequent-to-resection-of-ossification-of-anterior-longitudinal-ligament-in-dish
#10
Man-Kyu Park, Kyoung-Tae Kim, Dae-Chul Cho, Joo-Kyung Sung
PURPOSE: The presence of prominent OALL (ossification of anterior longitudinal ligament) in the anterior cervical spine has been implicated as a cause of dysphagia. Surgical resection of the OALL is considered effective for the management of diffuse idiopathic skeletal hyperostosis (DISH)-related dysphagia. Although many reports have been published on DISH-related dysphagia, no cases of postoperative cervical instability have been reported thus far. We present a case in which the patient developed myelopathy associated with instability consequent to resection of OALL in DISH...
July 27, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28743132/therapeutic-outcomes-of-endoscopic-resection-of-early-gastric-cancer-with-undifferentiated-type-histology-a-korean-esd-registry-database-analysis
#11
Chang Seok Bang, Jae Myung Park, Gwang Ho Baik, Jong Jae Park, Moon Kyung Joo, Jae Young Jang, Seong Woo Jeon, Suck Chei Choi, Jae Kyu Sung, Kwang Bum Cho
Background/Aims: To assess the therapeutic outcomes of endoscopic resection (ER) of early gastric cancer (EGC) with undifferentiated-type histology. Methods: Cases of ER of EGC with undifferentiated-type histology in the Korean endoscopic submucosal dissection (ESD) registry database were identified and reviewed. The immediate outcomes, including en bloc resection, complete resection, and curative resection rates, and long-term outcomes, including recurrence and survival rates, were extracted and analyzed...
July 25, 2017: Clinical Endoscopy
https://www.readbyqxmd.com/read/28742730/predictive-model-for-neoplastic-potential-of-gallbladder-polyp
#12
Ju-Il Yang, Jong Kyun Lee, Dae Geon Ahn, Joo Kyung Park, Kwang Hyuck Lee, Kyu Taek Lee, Sang Ah Chi, Sin-Ho Jung
GOAL: To provide the statistical predictive model for neoplastic potential of gallbladder polyp (GBP). BACKGROUND: Many studies have attempted to define the risk factors for neoplastic potential of GBP. It remains difficult to precisely adapt the reported risk factors for the decision of surgery. Estimating the probability for neoplastic potential of GBP using a combination of several risk factors before surgical resection would be useful in patient consultation...
July 24, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28705541/risk-factors-affecting-breast-cancer-related-lymphedema-serial-body-weight-change-during-neoadjuvant-anthracycline-plus-cyclophosphamide-followed-by-taxane
#13
Sungmin Park, Jeong Eon Lee, Jonghan Yu, Hyun-June Paik, Jai Min Ryu, Isaac Kim, Soo Youn Bae, Se Kyung Lee, Seok Won Kim, Seok Jin Nam, Eun-Kyu Kim, Eunyoung Kang, Eun Joo Yang
INTRODUCTION: The aim of our study was to analyze the risk of lymphedema (LE) according to the clinicopathologic factors and to investigate the serial change in body weight during neoadjuvant anthracycline plus cyclophosphamide followed by taxane and its correlation with the incidence of LE. PATIENTS AND METHODS: We performed a retrospective 2-center study of 406 patients who had undergone neoadjuvant chemotherapy (NAC) followed by surgery from 2007 to 2014. The regimen included 4 cycles of anthracycline plus cyclophosphamide, followed by 4 cycles of taxane...
June 21, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28703219/genome-wide-association-and-expression-quantitative-trait-loci-studies-identify-multiple-susceptibility-loci-for-thyroid-cancer
#14
Ho-Young Son, Yul Hwangbo, Seong-Keun Yoo, Sun-Wha Im, San Duk Yang, Soo-Jung Kwak, Min Seon Park, Soo Heon Kwak, Sun Wook Cho, Jun Sun Ryu, Jeongseon Kim, Yuh-Seog Jung, Tae Hyun Kim, Su-Jin Kim, Kyu Eun Lee, Do Joon Park, Nam Han Cho, Joohon Sung, Jeong-Sun Seo, Eun Kyung Lee, Young Joo Park, Jong-Il Kim
Thyroid cancer is the most common cancer in Korea. Several susceptibility loci of differentiated thyroid cancer (DTC) were identified by previous genome-wide association studies (GWASs) in Europeans only. Here we conducted a GWAS and a replication study in Koreans using a total of 1,085 DTC cases and 8,884 controls, and validated these results using expression quantitative trait loci (eQTL) analysis and clinical phenotypes. The most robust associations were observed in the NRG1 gene (rs6996585, P=1.08 × 10(-10)) and this SNP was also associated with NRG1 expression in thyroid tissues...
July 13, 2017: Nature Communications
https://www.readbyqxmd.com/read/28701722/asxl1-deficiency-in-embryonic-fibroblasts-leads-to-cellular-senescence-via-impairment-of-the-akt-e2f-pathway-and-ezh2-inactivation
#15
Hye Sook Youn, Tae-Yoon Kim, Ui-Hyun Park, Seung-Tae Moon, So-Jung An, Yong-Kyu Lee, Jin-Taek Hwang, Eun-Joo Kim, Soo-Jong Um
Although ASXL1 mutations are frequently found in human diseases, including myeloid leukemia, the cell proliferation-associated function of ASXL1 is largely unknown. Here, we explored the molecular mechanism underlying the growth defect found in Asxl1-deficient mouse embryonic fibroblasts (MEFs). We found that Asxl1, through amino acids 371 to 655, interacts with the kinase domain of AKT1. In Asxl1-null MEFs, IGF-1 was unable to induce AKT1 phosphorylation and activation; p27Kip1, which forms a ternary complex with ASXL1 and AKT1, therefore remained unphosphorylated...
July 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28693185/withaferin-a-inhibits-the-proliferation-of-gastric-cancer-cells-by-inducing-g2-m-cell-cycle-arrest-and-apoptosis
#16
Green Kim, Tae-Hyoun Kim, Eun-Ha Hwang, Kyu-Tae Chang, Jung Joo Hong, Jong-Hwan Park
Human gastric adenocarcinoma (AGS) is one of the most common types of malignant tumor and the third-leading cause of tumor-associated mortality worldwide. Withaferin A (WA), a steroidal lactone derived from Withania somnifera, exhibits antitumor activity in a variety of cancer models. However, to the best of our knowledge, the direct effect of WA on AGS cells has not previously been determined. The present study investigated the effects of WA on the proliferation and metastatic activity of AGS cells. WA exerted a dose-dependent cytotoxic effect on AGS cells...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28682944/a-simplified-mortality-score-using-delta-neutrophil-index-and-the-thrombotic-microangiopathy-score-for-prognostication-in-critically-ill-patients
#17
Eun Kyong Goag, Jong Wook Lee, Yun Ho Roh, Ah Young Leem, Song Yee Kim, Joo Han Song, Eun Young Kim, Ji Ye Jung, Moo Suk Park, Young Sam Kim, Se Kyu Kim, Joon Chang, Kyung Soo Chung
BACKGROUND: This study was conducted to assess the prognostic value of a simplified mortality score (SMS) using the delta neutrophil index (DNI) and thrombotic microangiopathy (TMA) score, both easily obtained from the complete blood count, to identify critically ill patients at high risk of death. METHODS: This was a retrospective study performed in the medical ICU at Yonsei University College of Medicine from June 2015 to February 2016. The primary end-point was 28-day all-cause mortality...
July 4, 2017: Shock
https://www.readbyqxmd.com/read/28673508/comparison-of-prasugrel-versus-clopidogrel-in-korean-patients-with-acute-myocardial-infarction-undergoing-successful-revascularization
#18
Keun-Ho Park, Myung Ho Jeong, Hyun Kuk Kim, Tae Hoon Ahn, Ki Bae Seung, Dong Joo Oh, Dong-Joo Choi, Hyo-Soo Kim, Hyeon Cheol Gwon, In Whan Seong, Kyung Kuk Hwang, Shung Chull Chae, Kwon-Bae Kim, Young Jo Kim, Kwang Soo Cha, Seok Kyu Oh, Jei Keon Chae
BACKGROUND: Although there have been several reports that prasugrel can improve clinical outcomes, the efficacy and safety of prasugrel is unknown in Korean patients with acute myocardial infarction (AMI) undergoing successful revascularization. METHODS: A total of 4421 patients [637 patients were prescribed prasugrel (60/10 or 5mg, loading/maintenance dose) and 3784 patients clopidogrel (600 or 300/75mg)] with AMI undergoing successful revascularization were enrolled from the core clinical cohort of Korea Acute Myocardial Infarction Registry-National Institute of Health...
June 30, 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/28666601/impact-of-a-cardiac-intensivist-on-mortality-in-patients-with-cardiogenic-shock
#19
Soo Jin Na, Taek Kyu Park, Ga Yeon Lee, Yang Hyun Cho, Chi Ryang Chung, Kyeongman Jeon, Gee Young Suh, Joong Hyun Ahn, Keumhee C Carriere, Young Bin Song, Jin-Oh Choi, Joo-Yong Hahn, Seung-Hyuk Choi, Hyeon-Cheol Gwon, Jeong Hoon Yang
BACKGROUND: This study aimed to evaluate the association between high-intensity staffing by a dedicated cardiac intensivist and clinical outcomes in CS. METHODS: We enrolled 2923 consecutive patients admitted to a cardiac care unit (CCU) from January 1, 2012 to December 31, 2015. In January 2013, the CCU changed from a low-intensity to high-intensity staffing unit managed by a dedicated cardiac intensivist. Patients were eligible if they required inotropes or vasopressors to maintain a systolic blood pressure>90mmHg, and had serum lactate≥2...
June 24, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28665063/uric-acid-level-has-a-u-shaped-association-with-clinical-outcomes-in-patients-with-vasospastic-angina
#20
Hye Bin Gwag, Jeong Hoon Yang, Taek Kyu Park, Young Bin Song, Joo Yong Hahn, Jin Ho Choi, Sang Hoon Lee, Hyeon Cheol Gwon, Seung Hyuk Choi
No data are available on the association of serum uric acid and vasospastic angina (VSA) which has endothelial dysfunction as a possible pathophysiologic mechanism. Low uric acid level might cause adverse outcomes in VSA in connection with endothelial dysfunction. We enrolled 818 VSA patients whose uric acid level was measured at admission. Patients were categorized according to tertiles of uric acid level: group I, ≤ 4.8 mg/dL; group II, 4.9-5.9 mg/dL; and group III, ≥ 6.0 mg/dL. Primary outcome was major adverse cardiac events (MACEs), defined as a composite of cardiac death, acute myocardial infarction (MI), ischemic stroke, coronary revascularization, and rehospitalization for angina...
August 2017: Journal of Korean Medical Science
keyword
keyword
31960
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"