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https://www.readbyqxmd.com/read/28634046/tumor-antigen-prame-is-up-regulated-by-mzf1-in-cooperation-with-dna-hypomethylation-in-melanoma-cells
#1
Yong-Kyu Lee, Ui-Hyun Park, Eun-Joo Kim, Jin-Taek Hwang, Ji-Cheon Jeong, Soo-Jong Um
Elevated expression of preferentially expressed antigen in melanoma (PRAME) has been implicated in disease progression in a variety of cancers. However, the mechanisms underlying the transcriptional regulation of PRAME remain largely unexplored. Initially, we observed that PRAME was elevated in proportion to the malignant potential of melanoma cells. From the in silico prediction of PRAME gene structure, we identified the putative myeloid zinc finger 1 (MZF1) binding sites, which overlap with a CpG-rich region located in the first intron...
June 17, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28612683/determination-of-26-anti-diabetic-compounds-in-dietary-supplements-using-a-validated-uplc-method
#2
Nam Sook Kim, Kyu Yeon Kim, Geum Joo Yoo, Ji Hyun Lee, Han Na Park, Sung-Kwan Park, Sun Young Baek
The purpose of this study was to validate a rapid, simple, and accurate method using ultra performance liquid chromatography (UPLC) for the simultaneous determination of 26 anti-diabetic compounds in illegally adulterated dietary supplements. The method was validated for specificity, linearity, limit of detection, limit of quantitation, precision, accuracy, recovery, and stability. All compounds were separated with a resolution of over 1.5. The limits of detection and quantitation were 0.10-1.70 and 0.30-5...
June 14, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/28611958/management-of-blood-loss-in-hip-arthroplasty-korean-hip-society-current-consensus
#3
REVIEW
Joo-Hyoun Song, Jang Won Park, Young-Kyun Lee, In-Sung Kim, Jae-Hwi Nho, Kyung-Jae Lee, Kwan Kyu Park, Yeesuk Kim, Jai Hyung Park, Seung Beom Han
The volume of hip arthroplasty is stiffly increasing because of excellent clinical outcomes, however it has not been shown to decrease the incidence of transfusions due to bleeding related to this surgery. This is an important consideration since there are concerns about the side effects and social costs of transfusions. First, anemia should be assessed at least 30 days before elective hip arthroplasty, and if the subject is diagnosed as having anemia, an additional examination of the cause of the anemia should be carried and steps taken to address the anemia...
June 2017: Hip & Pelvis
https://www.readbyqxmd.com/read/28596788/factors-requiring-adjustment-in-the-interpretation-of-serum-carcinoembryonic-antigen-a-cross-sectional-study-of-18-131-healthy-nonsmokers
#4
Hae Yeon Kang, Eun Kyung Choe, Kyu Joo Park, Young Lee
Serum carcinoembryonic antigen (CEA) is a well-known tumor marker for colorectal adenocarcinoma. However, CEA levels can be influenced by various nonmalignant conditions. A retrospective, cross-sectional study was performed including 18,131 healthy nonsmokers who underwent health check-ups with evaluation of the serum CEA level. In the training set, multivariate analysis revealed that the log-transformed CEA level had positive relationships with age (regression coefficient (r) = 0.005, P < 0.001), white blood cell (WBC) count (r = 0...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28595583/the-association-between-number-of-doctors-per-bed-and-readmission-of-elderly-patients-with-pneumonia-in-south-korea
#5
Joo Eun Lee, Tae Hyun Kim, Kyoung Hee Cho, Kyu-Tae Han, Eun-Cheol Park
BACKGROUND: There is an urgent need to reduce readmission of patients with pneumonia and improve quality of care. To assess the association between hospital resources and quality of care, we examined the effect of number of doctors per bed on 30-day readmission and investigated the combined effect of number of doctors per bed and number of beds. METHODS: We used nationwide cohort sample data of health insurance claims by the National Health Insurance Service (NHIS) from 2002 to 2013...
June 8, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28593634/first-isolation-of-rickettsia-monacensis-from-a-patient-south-korea
#6
Yeon-Sook Kim, Yeon-Joo Choi, Kyung-Min Lee, Kyu-Joong Ahn, Heung-Chul Kim, Terry Klein, Ju Jiang, Allen Richards, Kyung-Hee Park, Won-Jong Jang
A Rickettsia sp. was isolated from blood of a patient with acute febrile illness using the shell vial technique and the isolate was named as CN45Kr. The CN45Kr was identified as Rickettsia monacensis, which was recognized as a pathogen for the first time in Spain, by molecular assay. In sequencing analysis, gltA sequence of the isolate was identical to those of Rickettsia sp. IRS3. The ompA-5' fragment sequence showed 100% identity to R. monacensis and Rickettsia sp. In56 and ompA-3' fragments showed 99.9% similarity to Rickettsia sp...
June 7, 2017: Microbiology and Immunology
https://www.readbyqxmd.com/read/28592384/gender-differences-in-long-term-clinical-outcomes-and-prognostic-factors-in-patients-with-vasospastic-angina
#7
Da Hyon Lee, Taek Kyu Park, Choong Sil Seong, Hye Bin Gwag, A Young Lim, Min Seok Oh, Sung Woo Cho, Jeong Hoon Yang, Young Bin Song, Joo-Yong Hahn, Jin-Ho Choi, Sang Hoon Lee, Hyeon-Cheol Gwon, Seung-Hyuk Choi
BACKGROUND: Men are more likely to suffer from vasospastic angina (VSA) than women; however, gender differences in the long-term prognosis of VSA patients have not been fully elucidated. We sought to investigate clinical outcomes and predictive factors of VSA patients according to gender. METHODS: A total of 986 patients (838 men and 148 women) with a positive result on intracoronary ergonovine provocation test between January 2003 and December 2014 were analyzed...
May 26, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28586376/oncologic-and-surgical-outcomes-in-colorectal-cancer-patients-with-liver-cirrhosis-a-propensity-matched-study
#8
Eon Chul Han, Seung-Bum Ryoo, Ji Won Park, Jin Wook Yi, Heung-Kwon Oh, Eun Kyung Choe, Heon-Kyun Ha, Byung Kwan Park, Sang Hui Moon, Seung-Yong Jeong, Kyu Joo Park
The management of colorectal cancer in patients with liver cirrhosis requires a thorough understanding of both diseases. This study evaluated the effect of liver cirrhosis on oncologic and surgical outcomes and prognostic factors in colorectal cancer patients. Fifty-five consecutive colorectal cancer patients with liver cirrhosis underwent colorectal resection (LC group). Using a prospectively maintained database, these patients were matched 1:4 using propensity scoring with R programming language, package "MatchIt" and "optmatch" by sex, age, cancer location, and tumor stage with 220 patients without liver cirrhosis (non-LC group), resulting in 275 patients...
2017: PloS One
https://www.readbyqxmd.com/read/28579174/production-of-5-aminovaleric-acid-in-recombinant-corynebacterium-glutamicum-strains-from-a-miscanthus-hydrolysate-solution-prepared-by-a-newly-developed-miscanthus-hydrolysis-process
#9
Jeong Chan Joo, Young Hoon Oh, Ju Hyun Yu, Sung Min Hyun, Tae Uk Khang, Kyoung Hee Kang, Bong Keun Song, Kyungmoon Park, Min-Kyu Oh, Sang Yup Lee, Si Jae Park
This study examined nine expired industrial Corynebacterium glutamicum strains with high lysine producing capability for enhanced production of 5-AVA. C. glutamicum KCTC 1857 exhibiting the highest lysine production was transformed with either original Pseudomonas putida davBA genes, encoding the 5-AVA biosynthesis pathway, or C. glutamicum codon-optimized davBA genes. C. glutamicum KCTC 1857 expressing the original genes had superior cell viability and 5-AVA production capability compared to the other strain...
May 21, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28573447/identifying-long-term-survivors-among-metastatic-breast-cancer-patients-undergoing-primary-tumor-surgery
#10
Tae-Kyung Yoo, Byung Joo Chae, Sei Joong Kim, JungSun Lee, Tae In Yoon, Soo Jung Lee, Ho Yong Park, Heung Kyu Park, Yong Hwa Eom, Hyung Suk Kim, Chang Jong Kim, Man Sik Shin, Sun Hyong You, Byung Joo Song
PURPOSE: The prognostic role of primary tumor surgery in women with metastatic breast cancer at diagnosis is contentious. A subset of patients who will benefit from aggressive local treatment is needed to be identified. Using a nationwide database, we developed and validated a predictive model to identify long-term survivors among patients who had undergone primary tumor surgery. METHODS: A total of 150,043 patients were enrolled in the Korean Breast Cancer Registry between January 1990 and December 2014...
June 1, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28546522/redefining-the-positive-circumferential-resection-margin-by-incorporating-preoperative-chemoradiotherapy-treatment-response-in-locally-advanced-rectal-cancer-a-multicenter-validation-study
#11
Joo Ho Lee, Eui Kyu Chie, Seung-Yong Jeong, Tae-You Kim, Dae Yong Kim, Tae Hyun Kim, Sun Young Kim, Ji Yeon Baek, Hee Jin Hang, Min Ju Kim, Sung Chan Park, Jae Hwan Oh, Sung Hwan Kim, Jong Hoon Lee, Doo Ho Choi, Hee Chul Park, Sung-Bum Kang, Jae-Sung Kim
Purpose: This study was conducted to validate the prognostic influence of treatment response among patients with positive circumferential resection margin for locally advanced rectal cancer. Materials and Methods: Clinical data of 197 patients with positive circumferential resection margin defined as ≤ 2mm after preoperative chemoradiotherapy followed by total mesorectal excision between 2004 and 2009 were collected for this multicenter validation study. All patients underwent median 50...
May 24, 2017: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/28545442/anti-cancer-effect-of-scutellaria-baicalensis-in-combination-with-cisplatin-in-human-ovarian-cancer-cell
#12
Bo Yoon Choi, Jong Cheon Joo, Yeon Kyu Lee, Ik-Soon Jang, Soo Jung Park, Yoon Jung Park
BACKGROUND: Ovarian cancer is one of the major causes of death among females in worldwide. Cisplatin is a primary anti-cancer drug against ovarian cancer, but the recurrent tumors after treatment frequently show acquired chemoresistance. Extract of Scutellaria baicalensis (SbE) has been reported to have functional compounds including baicalin, which has anti-cancer effects. However, the anti-cancer effects of SbE in ovarian cancer and its underlying mechanisms are elusive. METHODS: We investigated that the effects of SbE and/or cisplatin on cell death in the cisplatin sensitive ovarian cancer cell line A2780 (CSC) and the counterpart cell line that has cisplatin resistance (CRC)...
May 25, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28533625/beneficial-effect-of-interventional-exercise-on-autistic-fragile-x-syndrome
#13
REVIEW
Seunghoon Lee, Jinyoung Won, Sookyoung Park, Sang-Rae Lee, Kyu-Tae Chang, Joo-Heon Kim, Yonggeun Hong
[Purpose] The purpose of the present review is to discuss recent published articles in the understanding of efficacy of interventional exercise on autistic Fragile X syndrome (FXS) with special emphasis on its significance in clinical application in patients. [Methods] This review article was identified scientifically and/or clinically relevant articles from PubMed that directly/indirectly met the inclusion criteria. [Results] Mutation of fragile X mental retardation 1 (fmr1) gene on the X chromosome is related with loss of fragile X mental retardation protein (FMRP) that affecting physiological and behavioral abnormalities...
April 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28526636/rebamipide-ameliorates-radiation-induced-intestinal-injury-in-a-mouse-model
#14
Sehwan Shim, Hyo-Sun Jang, Hyun-Wook Myung, Jae Kyung Myung, Jin-Kyu Kang, Min-Jung Kim, Seung Bum Lee, Won-Suk Jang, Sun-Joo Lee, Young-Woo Jin, Seung-Sook Lee, Sunhoo Park
Radiation-induced enteritis is a major side effect in cancer patients undergoing abdominopelvic radiotherapy. Radiation exposure produces an uncontrolled inflammatory cascade and epithelial cell loss leading to impaired epithelial barrier function. The goal of this study was to determine the effect of rebamipide on regeneration of the intestinal epithelia after radiation injury. The abdomens of C57BL/6 mice were exposed to 13Gy of irradiation (IR) and then the mice were treated with rebamipide. Upon IR, intestinal epithelia were destroyed structurally at the microscopic level and bacterial translocation was increased...
May 16, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28516074/an-updated-nationwide-epidemiology-of-primary-brain-tumors-in-republic-of-korea-2013
#15
Yun-Sik Dho, Kyu-Won Jung, Johyun Ha, Youngbeom Seo, Chul-Kee Park, Young-Joo Won, Heon Yoo
BACKGROUND: This report aims to provide accurate nationwide epidemiologic data on primary brain and central nervous system (CNS) tumors in the Republic of Korea. We updated the data by analyzing primary brain and CNS tumors diagnosed in 2013 using the data from the national cancer incidence database. METHODS: Data on primary brain and CNS tumors diagnosed in 2013 were collected from the Korean Central Cancer Registry. Crude and age-standardized rates were calculated in terms of gender, age, and histological type...
April 2017: Brain Tumor Research and Treatment
https://www.readbyqxmd.com/read/28513830/association-between-mutations-of-critical-pathway-genes-and-survival-outcomes-according-to-the-tumor-location-in-colorectal-cancer
#16
Dae-Won Lee, Sae-Won Han, Yongjun Cha, Jeong Mo Bae, Hwang-Phill Kim, Jaemyun Lyu, Hyojun Han, Hyoki Kim, Hoon Jang, Duhee Bang, Iksoo Huh, Taesung Park, Jae-Kyung Won, Seung-Yong Jeong, Kyu Joo Park, Gyeong Hoon Kang, Tae-You Kim
BACKGROUND: Colorectal cancer (CRC) develops through the alteration of several critical pathways. This study was aimed at evaluating the influence of critical pathways on survival outcomes for patients with CRC. METHODS: Targeted next-generation sequencing of 40 genes included in the 5 critical pathways of CRC (WNT, P53, RTK-RAS, phosphatidylinositol-4,5-bisphosphate 3-kinase [PI3K], and transforming growth factor β [TGF-β]) was performed for 516 patients with stage III or high-risk stage II CRC treated with surgery followed by adjuvant fluoropyrimidine and oxaliplatin chemotherapy...
May 17, 2017: Cancer
https://www.readbyqxmd.com/read/28497920/prevalence-of-self-reported-allergic-diseases-and-ige-levels-a-2010-knhanes-analysis
#17
Hye Jung Park, Eun Jin Kim, Dankyu Yoon, Jeom Kyu Lee, Woo Sung Chang, Yoen Mi Lim, Jung Won Park, Joo Shil Lee
PURPOSE: The prevalence of allergic diseases is known to be associated with both demographic and environmental factors. Herein, we aimed to determine significant factors associated with the prevalence of allergic diseases and with total immunoglobulin E (tIgE) and specific immunoglobulin E (sIgE) levels in Korea. METHODS: We analyzed unweighted data collected by the 2010 Korea National Health and Nutrition Examination Survey for 2,342 subjects who underwent serum tests for tIgE and sIgE to Dermatophagoides farinae, dog, and Blattella germanica, representing a sample of 16,003,645 citizens, by considering the sample weight and stratification...
July 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/28484270/risk-factors-for-pneumocystis-jirovecii-pneumonia-pjp-in-kidney-transplantation-recipients
#18
Su Hwan Lee, Kyu Ha Huh, Dong Jin Joo, Myoung Soo Kim, Soon Il Kim, Juhan Lee, Moo Suk Park, Young Sam Kim, Se Kyu Kim, Joon Chang, Yu Seun Kim, Song Yee Kim
Pneumocystis jirovecii pneumonia (PJP) is a potentially life-threatening infection that occurs in immunocompromised patients. The aim of this study was to evaluate risk factors for PJP in kidney transplantation recipients. We conducted a retrospective analysis of patient data from 500 consecutive kidney transplants performed at Severance Hospital between April 2011 and April 2014. Eighteen kidney transplantation recipients (3.6%) were diagnosed with PJP. In the univariate analysis, acute graft rejection, CMV infection, use of medication for diabetes mellitus, and lowest lymphocyte count were associated with PJP...
May 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28475584/duration-of-dual-antiplatelet-therapy-in-patients-treated-with-percutaneous-coronary-intervention-for-coronary-chronic-total-occlusion
#19
Seung Hwa Lee, Jeong Hoon Yang, Seung-Hyuk Choi, Taek Kyu Park, Woo Jin Jang, Young Bin Song, Joo-Yong Hahn, Jin-Ho Choi, Hyeon-Cheol Gwon
BACKGROUND: The duration of dual antiplatelet therapy (DAPT) after drug-eluting stent implantation in coronary chronic total occlusion (CTO) remains unclear. METHODS: We retrospectively analyzed a total of 512 patients treated with percutaneous coronary intervention (PCI) in the Samsung Medical Center CTO registry. Patients were separated into ≤ 12-month (199, 38.9%) vs. > 12 month (313, 61.1%) based on DAPT duration with aspirin and clopidogrel. The primary outcome was major adverse cardiac and cerebrovascular event (MACCE) during follow-up...
2017: PloS One
https://www.readbyqxmd.com/read/28462902/two-stent-techniques-for-coronary-bifurcation-lesions-main-vessel-first-versus-side-branch-first-results-from-the-cobis-coronary-bifurcation-stenting-ii-registry
#20
Taek Kyu Park, Young Bin Song, Jeong Hoon Yang, Joo Myung Lee, Joo-Yong Hahn, Seung-Hyuk Choi, Jin-Ho Choi, Sang Hoon Lee, Ju Hyeon Oh, Cheol Woong Yu, Jin-Ok Jeong, Hyeon-Cheol Gwon
AIMS: It has not been known which 2-stent technique is best for treating bifurcation lesions. We compared the outcomes from main vessel (MV) first and side branch (SB) first techniques for patients with bifurcation lesions requiring 2-stent approach. METHODS AND RESULTS: A total of 673 patients with bifurcation lesions were treated with 2- stent techniques-MV first (n=250) or SB first (n=423). The rate of a composite of cardiac death, myocardial infarction, or target lesion revascularization (TLR) was similar in the 2 groups (SB first versus MV first, 15...
May 2, 2017: EuroIntervention
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