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https://www.readbyqxmd.com/read/29916538/pep%C3%A2-1%C3%A2-glutaredoxin-1-protects-against-hippocampal-neuronal-cell-damage-from-oxidative-stress-via-regulation-of-mapk-and-apoptotic-signaling-pathways
#1
Eun Ji Ryu, Dae Won Kim, Min Jea Shin, Hyo Sang Jo, Jung Hwan Park, Su Bin Cho, Chi Hern Lee, Hyeon Ji Yeo, Eun Ji Yeo, Yeon Joo Choi, Duk-Soo Kim, Sung-Woo Cho, Yong-Jun Cho, Eun Jeong Sohn, Ora Son, Keun Wook Lee, Kyu Hyung Han, Jinseu Park, Won Sik Eum, Soo Young Choi
Oxidative stress is known to be a primary risk factor for neuronal diseases. Glutaredoxin (GLRX)‑1, a redox‑regulator of the thioredoxin superfamily, is known to exhibit an important role in cell survival via various cellular functions. However, the precise roles of GLRX1 in brain ischemia are still not fully understood. The present study investigated whether transduced PEP‑1‑GLRX1 protein has protective effects against oxidative stress in cells and in an animal model. Transduced PEP‑1‑GLRX1 protein increased HT‑22 cell viability under oxidative stress and this fusion protein significantly reduced intracellular reactive oxygen species and levels of DNA damage...
June 15, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29905089/thyroid-cancer-treatment-choice-a-pilot-study-of-a-tool-to-facilitate-conversations-with-patients-with-papillary-microcarcinomas-considering-treatment-options
#2
Juan P Brito, Jae Hoon Moon, Rebecca Zeuren, Sung Hye Kong, Yeo Koon Kim, Nicole M Iñiguez-Ariza, June Young Choi, Kyu Eun Lee, Ji-Hoon Kim, Ian Hargraves, Victor Bernet, Victor Montori, Young Joo Park, R Michael Tuttle
BACKGROUND: The 2015 American Thyroid Association guidelines recognize active surveillance as an alternative to immediate surgery in patients with papillary microcarcinomas (PMCs). As a way to incorporate active surveillance as one of the management options for patients with PMCs, we describe the development and initial testing of a tool to support conversations between clinicians and patients with PMCs considering treatment options. METHODS: Thyroid Cancer Treatment Choice was developed using an iterative process based on the principles of interaction, design and participatory action research...
June 15, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29901104/b7%C3%A2-h1%C3%A2-mediated-immunosuppressive-properties-in-human-mesenchymal-stem-cells-are-mediated-by-stat%C3%A2-1-and-not-pi3k-akt-signaling
#3
In Keun Jang, Hyun Joo Jung, O Kyu Noh, Doo-Hoon Lee, Kwang Chul Lee, Jun Eun Park
Mesenchymal stem cells (MSCs), derived from either bone marrow (BM) or Wharton's jelly (WJ), inhibit the proliferation of activated T cells, and interferon (IFN)‑γ serves an important role in this process. This process is B7‑homolog (H)1‑dependent during cell contact inhibition. However, the signaling pathway involved in B7‑H1 expression in MSCs remains largely undefined. The present study demonstrated activation of B7‑H1 by engaging signal transducer and activator of transcription (STAT)‑1 signaling in MSCs...
May 30, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29899202/revascularization-vs-medical-therapy-for-coronary-chronic-total-occlusions-in-patients-with-chronic-kidney-disease
#4
Chung Hun Kim, Jeong Hoon Yang, Taek Kyu Park, Young Bin Song, Joo-Yong Hahn, Jin-Ho Choi, Sang Hoon Lee, Hyeon-Cheol Gwon, Joonghyun Ahn, Keumhee Chough Carriere, Seung-Hyuk Choi
BACKGROUND: We investigated whether the outcome of revascularization differed from the outcome of medical therapy in chronic kidney disease (CKD) and non-CKD patients with chronic total occlusion (CTO).Methods and Results:A total of 2,010 patients with CTO who underwent revascularization (n=1,355), including percutaneous coronary intervention (n=878) and coronary artery bypass grafting (n=477), or had medical therapy alone (n=655) were examined. The primary outcome was all-cause death during follow-up...
June 14, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/29892844/fine-mapping-and-candidate-gene-analysis-of-the-quantitative-trait-locus-gw8-1-associated-with-grain-length-in-rice
#5
Yun-Joo Kang, Kyu-Chan Shim, Hyun-Sook Lee, Yun-A Jeon, Sun-Ha Kim, Ju-Won Kang, Yeo-Tae Yun, In-Kyu Park, Sang-Nag Ahn
A quantitative trait locus (QTL) gw8.1 was detected in the population derived from a cross between the elite japonica cultivar, 'Hwaseong' and Oryza rufipogon (IRGC 105491). Near isogenic lines (NILs) harboring the O. rufipogon segment on chromosome 8 showed increased grain length and weight compared to those of the recurrent parent, Hwaseong. This QTL was mapped to a 175.3-kb region containing 28 genes, of which four were considered as candidates based on the presence of mutations in their coding regions and as per the RNA expression pattern during the inflorescence stage...
April 2018: Genes & Genomics
https://www.readbyqxmd.com/read/29891952/publisher-correction-precisely-printable-and-biocompatible-silk-fibroin-bioink-for-digital-light-processing-3d-printing
#6
Soon Hee Kim, Yeung Kyu Yeon, Jung Min Lee, Janet Ren Chao, Young Jin Lee, Ye Been Seo, Md Tipu Sultan, Ok Joo Lee, Ji Seung Lee, Sung-Il Yoon, In-Sun Hong, Gilson Khang, Sang Jin Lee, James J Yoo, Chan Hum Park
The original version of this Article contained errors in Figs. 5 and 6. In Fig. 5b, the second panel on the bottom row was stretched out of proportion. In Fig. 6d, the first panel was also stretched out of proportion. In Fig. 6f, the fifth panel inadvertently repeated the fourth. This has been corrected in both the PDF and HTML versions of the Article.
June 11, 2018: Nature Communications
https://www.readbyqxmd.com/read/29890139/anti-melanogenic-activity-of-schaftoside-in-rhizoma-arisaematis-by-increasing-autophagy-in-b16f1-cells
#7
Pan Soo Kim, Ji Hyun Shin, Doo Sin Jo, Dong Woon Shin, Dong-Hwa Choi, Woo Jung Kim, Kyuhee Park, Jin Kyu Kim, Chul Gue Joo, Jong Suk Lee, Yongmun Choi, Yong Won Shin, Joong Jin Shin, Hong Bae Jeon, Jin-Ho Seo, Dong-Hyung Cho
Skin pigmentation involves multiple processes, including melanin synthesis, transport, and melanosome release. Melanin content determines skin color and protects against UV radiation-induced damage. Autophagy is a cooperative process between autophagosomes and lysosomes that degrades cellular components and organelles. In the present study, B16F1 cells were treated with Rhizoma Arisaematis extract (RA) and assessed for pigmentation and autophagy regulation. RA treatment suppressed the α-MSH-stimulated increase of melanogenesis and down-regulated the expression of tyrosinase and TRP1 proteins in B16F1 cells...
June 8, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29874985/prognostic-implications-of-hepatitis-b-virus-infection-in-intrahepatic-cholangiocarcinoma-treated-with-first-line-gemcitabine-plus-cisplatin
#8
Heejung Chae, Hyungwoo Cho, Changhoon Yoo, Kyu-Pyo Kim, Jae Ho Jeong, Heung-Moon Chang, Jihoon Kang, Han Chu Lee, Young-Suk Lim, Kang Mo Kim, Ju Hyun Shim, Sang Soo Lee, Do Hyun Park, Tae Jun Song, Shin Hwang, Gi-Won Song, Deok-Bog Moon, Young-Joo Lee, Jae Hoon Lee, Baek-Yeol Ryoo
PURPOSE: Hepatitis B virus infection is a well-known risk factor for intrahepatic cholangiocarcinoma. However, its prognostic impact has rarely been investigated in advanced intrahepatic cholangiocarcinoma. METHODS: Between April 2010 and May 2015, 296 patients with unresectable or metastatic intrahepatic cholangiocarcinoma who received gemcitabine plus cisplatin (GemCis) were categorized into a hepatitis B virus group (n=62; 21%) and a non-hepatitis B virus group (n=234; 79%)...
June 1, 2018: International Journal of Biological Markers
https://www.readbyqxmd.com/read/29843633/changes-in-ovarian-cancer-survival-during-the-20-years-before-the-era-of-targeted-therapy
#9
Jung-Yun Lee, Sunghoon Kim, Young Tae Kim, Myong Cheol Lim, Boram Lee, Kyu-Won Jung, Jae Weon Kim, Sang-Yoon Park, Young-Joo Won
BACKGROUND: The survival of patients with ovarian cancer has improved because of surgery and chemotherapy. This study aimed to estimate the changes in survival rates among Korean women with ovarian cancer prior to the introduction of targeted therapy for ovarian cancer. METHODS: Data were obtained from the Korea Central Cancer Registry regarding patients who were diagnosed with epithelial ovarian cancer between 1995 and 2014. The relative survival rates were calculated for 5-year periods using the Ederer II method...
May 29, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29798774/impact-of-optimized-procedure-related-factors-in-drug-eluting-balloon-angioplasty-for-treatment-of-in-stent-restenosis
#10
Tae-Min Rhee, Joo Myung Lee, Eun-Seok Shin, Doyeon Hwang, Jonghanne Park, Ki-Hyun Jeon, Hack-Lyoung Kim, Han-Mo Yang, Jung-Kyu Han, Kyung Woo Park, Joo-Yong Hahn, Bon-Kwon Koo, Sang-Hyun Kim, Hyo-Soo Kim
OBJECTIVES: The aim of this study was to investigate the impact of optimizing procedure-related factors during drug-eluting balloon (DEB) angioplasty on clinical outcomes of drug-eluting stent in-stent restenosis (ISR). BACKGROUND: Although DEB angioplasty is recommended as a reasonable option for ISR, recurrent target lesion failure (TLF) still occurs in many patients after DEB angioplasty. METHODS: Consecutive patients with drug-eluting stent ISR treated with DEB (SeQuent Please) were collected from 4 centers in Korea...
May 28, 2018: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29779869/genotypic-characteristics-and-their-association-with-phenotypic-characteristics-of-hereditary-medullary-thyroid-carcinoma-in-korea
#11
Kyong Yeun Jung, Seok-Mo Kim, Min Joo Kim, Sun Wook Cho, Bup-Woo Kim, Yong Sang Lee, Jong Ju Jeong, Kee-Hyun Nam, Woong Youn Chung, Kyu Eun Lee, Eun-Jae Chung, Hyo Jeong Kim, Do Joon Park, Myung-Whun Sung, Cheong Soo Park, Bo Young Cho, Young Joo Park, Hang-Seok Chang
BACKGROUND: Hereditary medullary thyroid carcinoma can present as a part of multiple endocrine neoplasia syndrome by rearranged during transfection gene mutation. We evaluated the prevalence of rearranged during transfection gene mutation in patients who have medullary thyroid carcinoma and the correlations of genotype with medullary thyroid carcinoma, pheochromocytoma, and hyperparathyroidism according to the revised American Thyroid Association risk level. METHODS: A total of 331 patients were diagnosed with medullary thyroid carcinoma, 172 of whom were tested for the rearranged during transfection germline mutation by sequencing of exon 8, 10, 11, and 13-16...
May 17, 2018: Surgery
https://www.readbyqxmd.com/read/29776611/nasal-delivery-of-chitosan-alginate-nanoparticle-encapsulated-bee-apis-mellifera-venom-promotes-antibody-production-and-viral-clearance-during-porcine-reproductive-and-respiratory-syndrome-virus-infection-by-modulating-t-cell-related-responses
#12
Jina Lee, Yun-Mi Kim, Ju-Heon Kim, Cheong-Weon Cho, Jong-Woon Jeon, Jin-Kyu Park, Sang-Ho Lee, Bock-Gie Jung, Bong-Joo Lee
In this study, we administered specially developed chitosan/alginate nanoparticle encapsulated BV (CH/AL-BV) which has slow-releasing properties and mucosal adhesiveness to pig via nasal route and evaluate whether it can facilitate systemic immune response and improve clearance of porcine reproductive and respiratory syndrome virus (PRRSV). The CH/AL-BV-administered group with PRRSV vaccination showed significantly enhanced Th1-related responses including a high population of CD4+ T lymphocyte and cytokine mRNA levels including interferon-gamma (IFN-γ) and interleukin (IL)-12 and increased PRRSV-specific IgG levels...
June 2018: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/29764713/utility-of-grace-and-acuity-horizons-risk-scores-to-guide-dual-antiplatelet-therapy-in-korean-patients-with-acute-myocardial-infarction-undergoing-drug-eluting-stenting
#13
Doo Sun Sim, Myung Ho Jeong, Hyo Soo Kim, Hyeon Cheol Gwon, Ki Bae Seung, Seung Woon Rha, Shung Chull Chae, Chong Jin Kim, Kwang Soo Cha, Jong Sun Park, Jung Han Yoon, Jei Keon Chae, Seung Jae Joo, Dong Ju Choi, Seung Ho Hur, In Whan Seong, Myeong Chan Cho, Doo Il Kim, Seok Kyu Oh, Tae Hoon Ahn, Jin Yong Hwang
BACKGROUND: Dual antiplatelet therapy (DAPT) is recommended in patients receiving drug-eluting stents (DES). However, bleeding risk should be weighed against ischemic risk. Utility of GRACE risk score and ACUITY-HORIZONS bleeding risk score was assessed in patients with acute myocardial infarction (MI) according to use of P2Y12 blocker. METHODS: From the Korea Acute Myocardial Infarction Registry-National Institute of Health database, 7791 patients with acute MI receiving DES were divided into ticagrelor (n=1554) and clopidogrel (n=6237) groups...
May 12, 2018: Journal of Cardiology
https://www.readbyqxmd.com/read/29751955/outcomes-in-patients-with-diabetes-mellitus-according-to-insulin-treatment-after-percutaneous-coronary-intervention-in-the-second-generation-drug-eluting-stent-era
#14
Seung-Hoon Pi, Tae-Min Rhee, Joo Myung Lee, Doyeon Hwang, Jonghanne Park, Taek Kyu Park, Jeong Hoon Yang, Young Bin Song, Jin-Ho Choi, Joo-Yong Hahn, Byung Jin Kim, Bum Soo Kim, Hyeon-Cheol Gwon, Seung-Hyuk Choi
Limited data exist regarding the clinical outcomes of patients with diabetes mellitus (DM) after percutaneous coronary intervention (PCI) using second-generation drug-eluting stents (DES), especially according to DM treatment. The purpose of this study was to compare clinical outcomes among patients without DM, with non-insulin-treated DM (non-ITDM), and with ITDM after PCI using second-generation DES. We analyzed 4,812 consecutive patients who underwent PCI using second-generation DES. Primary outcomes were patient-oriented composite outcome (a composite of all-cause mortality, any myocardial infarction, and any revascularization) at 3 years...
April 18, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29748007/added-prognostic-value-of-ct-characteristics-and-iaslc-ats-ers-histologic-subtype-in-surgically-resected-lung-adenocarcinomas
#15
Young Joo Suh, Hyun-Ju Lee, Young Tae Kim, Chang Hyun Kang, In Kyu Park, Yoon Kyung Jeon, Doo Hyun Chung
OBJECTIVES: Our study investigates the added value of computed tomography (CT) characteristics, histologic subtype classification of the International Association for the Study of Lung Cancer (IASLC)/the American Thoracic Society (ATS)/the European Respiratory Society (ERS), and genetic mutation for predicting postoperative prognoses of patients who received curative surgical resections for lung adenocarcinoma. MATERIALS AND METHODS: We retrospectively enrolled 988 patients who underwent curative resection for invasive lung adenocarcinoma between October 2007 and December 2013...
June 2018: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/29732357/validation-of-the-korean-version-of-visual-analogue-scale-for-irritable-bowel-syndrome-questionnaire-for-assessment-of-defecation-pattern-changes
#16
Hong Yeol Yoo, Boram Park, Jungnam Joo, Jung-Sup Kim, Yumi Lee, Myong Cheol Lim, Dae Kyung Sohn, Sung-Bum Kang, Kyu Joo Park
Purpose: Patients often complain of change of defecation pattern and it is necessary to quantify their symptoms. To quantify symptoms, use of questionnaire is ideal, so we adopted a simple and easily writable visual analogue scale for irritable bowel syndrome questionnaire (VAS-IBS). The aim of this study was to develop and validate the Korean version of VAS-IBS questionnaire (Korean VAS-IBS) that can adequately reflect the defecation pattern. Methods: This study translated English VAS-IBS into Korean using the forward-and-back translation method...
May 2018: Annals of Surgical Treatment and Research
https://www.readbyqxmd.com/read/29729957/comparison-of-adherence-to-glimepiride-metformin-sustained-release-once-daily-versus-glimepiride-metformin-immediate-release-bid-fixed-combination-therapy-using-the-medication-event-monitoring-system-in-patients-with-type-2-diabetes
#17
Jong-Dai Kim, Cheol-Young Park, Bong-Yun Cha, Kyu Jeung Ahn, In Joo Kim, Kyong Soo Park, Hyung Woo Lee, Kyung-Wan Min, Jong Chul Won, Min Young Chung, Jae-Taek Kim, Jun Goo Kang, Sung-Woo Park
PURPOSE: The purpose of this study was to compare the adherence of the glimepiride/metformin sustained release (GM-SR) once-daily fixed-dose combination and glimepiride/metformin immediate release (GM-IR) BID fixed-dose combination in type 2 diabetes therapies. METHODS: An open-label, randomized, multicenter, parallel-group study was conducted at 11 hospitals in the Republic of Korea. A total of 168 patients with type 2 diabetes treated with >4 mg of glimepiride and 1000 mg of metformin by using free or fixed-dose combination therapy for at least 2 weeks were enrolled...
May 2, 2018: Clinical Therapeutics
https://www.readbyqxmd.com/read/29720381/whole-exome-and-transcriptome-analyses-integrated-with-microenvironmental-immune-signatures-of-lung-squamous-cell-carcinoma
#18
Jeong-Sun Seo, Ji Won Lee, Ahreum Kim, Jong-Yeon Shin, Yoo Jin Jung, Sae Bom Lee, Yoon Ho Kim, Samina Park, Hyun Joo Lee, In-Kyu Park, Chang Hyun Kang, Ji-Young Yun, Jihye Kim, Young T Kim
The immune microenvironment in lung squamous cell carcinoma (LUSC) is not well understood, with interactions between the host immune system and the tumor, as well as the molecular pathogenesis of LUSC, awaiting better characterization. To date, no molecularly targeted agents have been developed for LUSC treatment. Identification of predictive and prognostic biomarkers for LUSC could help optimize therapy decisions. We sequenced whole exomes and RNA from 101 tumors and matched noncancer control Korean samples...
May 2, 2018: Cancer Immunology Research
https://www.readbyqxmd.com/read/29699061/expression-of-fibroblast-growth-factor-21-and-%C3%AE-klotho-regulates-hepatic-fibrosis-through-the-nuclear-factor-%C3%AE%C2%BAb-and-c-jun-n-terminal-kinase-pathways
#19
Kyong Joo Lee, Yoon Ok Jang, Seung-Kuy Cha, Moon Young Kim, Kyu-Sang Park, Young Woo Eom, Soon Koo Baik
Background/Aims: Fibroblast growth factor (FGF) 21 is associated with hepatic inflammation and fibrosis. However, little is known regarding the effects of inflammation and fibrosis on the β-Klotho and FGF21 pathway in the liver. Methods: Enrolled patients had biopsy-confirmed viral or alcoholic hepatitis. FGF19, FGF21 and β-Klotho levels were evaluated using enzyme-linked immunosorbent assay, real-time polymerase chain reaction, and Western blotting. Furthermore, we explored the underlying mechanisms for this process by evaluating nuclear factor-κB (NF-κB) and c-Jun N-terminal kinase (JNK) pathway involvement in Huh-7 cells...
April 27, 2018: Gut and Liver
https://www.readbyqxmd.com/read/29693652/precisely-printable-and-biocompatible-silk-fibroin-bioink-for-digital-light-processing-3d-printing
#20
Soon Hee Kim, Yeung Kyu Yeon, Jung Min Lee, Janet Ren Chao, Young Jin Lee, Ye Been Seo, Md Tipu Sultan, Ok Joo Lee, Ji Seung Lee, Sung-Il Yoon, In-Sun Hong, Gilson Khang, Sang Jin Lee, James J Yoo, Chan Hum Park
Although three-dimensional (3D) bioprinting technology has gained much attention in the field of tissue engineering, there are still several significant engineering challenges to overcome, including lack of bioink with biocompatibility and printability. Here, we show a bioink created from silk fibroin (SF) for digital light processing (DLP) 3D bioprinting in tissue engineering applications. The SF-based bioink (Sil-MA) was produced by a methacrylation process using glycidyl methacrylate (GMA) during the fabrication of SF solution...
April 24, 2018: Nature Communications
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