keyword
https://read.qxmd.com/read/38497337/evaluation-of-the-clinical-usefulness-of-pancreatic-alpha-amylase-as-a-novel-biomarker-in-dogs-with-acute-pancreatitis-a-pilot-study
#1
JOURNAL ARTICLE
Keon Kim, Hee-Hong Kim, Jae-Beom Joo, Ock-Kyu Kim, Sin-Wook Park, Guk-Hyun Suh, Woong-Bin Ro, Chang-Min Lee
Pancreatic alpha amylase (P-AMY) is used as a biomarker of acute pancreatitis (AP) in human medicine. To our knowledge, there are no studies evaluating the usefulness of P-AMY in dogs with AP. In this study, we evaluated the diagnostic value of P-AMY, currently not verified in veterinary medicine. The AP group ( n  = 40) consisted of dogs with AP diagnosed using clinical signs and laboratory examinations, including abnormal canine pancreatic lipase (cPL) concentration, and compatible abdominal ultrasound examination at first presentation...
December 2024: Veterinary Quarterly
https://read.qxmd.com/read/38487833/prediction-of-cancer-incidence-and-mortality-in-korea-2024
#2
JOURNAL ARTICLE
Kyu-Won Jung, Mee Joo Kang, Eun Hye Park, E Hwa Yun, Hye-Jin Kim, Jeong-Eun Kim, Hyun-Joo Kong, Jeong-Soo Im, Hong Gwan Seo
PURPOSE: This study aimed to report the projected cancer incidence and mortality for the year 2024 to estimate Korea's current cancer burden. MATERIALS AND METHODS: Cancer incidence data from 1999 to 2021 were obtained from the Korea National Cancer Incidence Database, and cancer mortality data from 1993 to 2022 were acquired from Statistics Korea. Cancer incidence and mortality were projected by fitting a linear regression model to observed age-specific cancer rates against their respective years and multiplying the projected age-specific rates by the anticipated age-specific population for 2024...
March 11, 2024: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://read.qxmd.com/read/38487832/cancer-statistics-in-korea-incidence-mortality-survival-and-prevalence-in-2021
#3
JOURNAL ARTICLE
Eun Hye Park, Kyu-Won Jung, Nam Ju Park, Mee Joo Kang, E Hwa Yun, Hye-Jin Kim, Jeong-Eun Kim, Hyun-Joo Kong, Jeong-Soo Im, Hong Gwan Seo
PURPOSE: The current study provides national cancer statistics and their secular trends in Korea, including incidence, mortality, survival, and prevalence in 2021. MATERIALS AND METHODS: Incidence, survival, and prevalence rates of cancer were calculated using the Korea National Cancer Incidence Database, from 1999 to 2021, with survival follow-up until December 31, 2022. Deaths from cancer were assessed using causes-of-death data obtained from Statistics Korea...
March 13, 2024: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://read.qxmd.com/read/38477501/glycemic-traits-and-colorectal-cancer-survival-in-a-cohort-of-south-korean-patients-a-mendelian-randomization-analysis
#4
JOURNAL ARTICLE
So Yon Jun, Sooyoung Cho, Min Jung Kim, Ji Won Park, Seung-Bum Ryoo, Seung Yong Jeong, Kyu Joo Park, Aesun Shin
BACKGROUND: Clinical diabetic traits have been reported to be associated with increased colorectal cancer (CRC) risk in observational studies. Using the Mendelian randomization (MR) analysis method, we examined the causal association between glycemic traits, such as fasting glucose (FG), fasting insulin (FI), and glycosylated hemoglobin A1c (HbA1c), and survival in a cohort of CRC patients. METHODS: We conducted a two-sample MR analysis among a cohort of patients with locally advanced CRC at Seoul National University Hospital...
March 2024: Cancer Medicine
https://read.qxmd.com/read/38477162/cost-effectiveness-of-intravascular-imaging-guided-complex-pci-prespecified-analysis-of-renovate-complex-pci-trial
#5
JOURNAL ARTICLE
David Hong, Jin Lee, Hankil Lee, Juhee Cho, Eliseo Guallar, Ki Hong Choi, Seung Hun Lee, Doosup Shin, Jong-Young Lee, Seung-Jae Lee, Sang Yeub Lee, Sang Min Kim, Kyeong Ho Yun, Jae Young Cho, Chan Joon Kim, Hyo-Suk Ahn, Chang-Wook Nam, Hyuck-Jun Yoon, Yong Hwan Park, Wang Soo Lee, Taek Kyu Park, Jeong Hoon Yang, Seung-Hyuk Choi, Hyeon-Cheol Gwon, Young Bin Song, Joo-Yong Hahn, Danbee Kang, Joo Myung Lee
BACKGROUND: Although clinical benefits of intravascular imaging-guided percutaneous coronary intervention (PCI) in patients with complex coronary artery lesions have been observed in previous trials, the cost-effectiveness of this strategy is uncertain. METHODS: RENOVATE-COMPLEX-PCI (Randomized Controlled Trial of Intravascular Imaging Guidance vs Angiography-Guidance on Clinical Outcomes After Complex Percutaneous Coronary Intervention) was conducted in Korea between May 2018 and May 2021...
March 13, 2024: Circulation. Cardiovascular Quality and Outcomes
https://read.qxmd.com/read/38470900/shock-indices-are-associated-with-in-hospital-mortality-among-patients-with-septic-shock-and-normal-left-ventricular-ejection-fraction
#6
JOURNAL ARTICLE
Kyu Jin Lee, Yong Kyun Kim, Kyeongman Jeon, Ryoung-Eun Ko, Gee Young Suh, Dong Kyu Oh, Sung Yoon Lim, Yeon Joo Lee, Su Yeon Lee, Mi-Hyeon Park, Chae-Man Lim, Sunghoon Park
BACKGROUND: The understanding of shock indices in patients with septic shock is limited, and their values may vary depending on cardiac function. METHODS: This prospective cohort study was conducted across 20 university-affiliated hospitals (21 intensive care units [ICUs]). Adult patients (≥19 years) with septic shock admitted to the ICUs during a 29-month period were included. The shock index (SI), diastolic shock index (DSI), modified shock index (MSI), and age shock index (Age-SI) were calculated at sepsis recognition (time zero) and ICU admission...
2024: PloS One
https://read.qxmd.com/read/38463680/differential-impact-of-fractional%C3%A2-flow%C3%A2-reserve-measured-after%C3%A2-coronary-stent-implantation-by-left-ventricular%C3%A2-dysfunction
#7
JOURNAL ARTICLE
Ki Hong Choi, Woochan Kwon, Doosup Shin, Seung-Hun Lee, Doyeon Hwang, Jinlong Zhang, Chang-Wook Nam, Eun-Seok Shin, Joon-Hyung Doh, Shao-Liang Chen, Tsunekazu Kakuta, Gabor G Toth, Zsolt Piroth, Abdul Hakeem, Barry F Uretsky, Yohei Hokama, Nobuhiro Tanaka, Hong-Seok Lim, Tsuyoshi Ito, Akiko Matsuo, Lorenzo Azzalini, Massoud A Leesar, Joost Daemen, Damien Collison, Carlos Collet, Bernard De Bruyne, Bon-Kwon Koo, Taek Kyu Park, Jeong Hoon Yang, Young Bin Song, Joo-Yong Hahn, Seung-Hyuk Choi, Hyeon-Cheol Gwon, Joo Myung Lee
BACKGROUND: Both left ventricular systolic function and fractional flow reserve (FFR) are prognostic factors after percutaneous coronary intervention (PCI). However, how these prognostic factors are inter-related in risk stratification of patients after PCI remains unclarified. OBJECTIVES: This study evaluated differential prognostic implication of post-PCI FFR according to left ventricular ejection fraction (LVEF). METHODS: A total of 2,965 patients with available LVEF were selected from the POST-PCI FLOW (Prognostic Implications of Physiologic Investigation After Revascularization with Stent) international registry of patients with post-PCI FFR measurement...
March 2024: JACC Asia
https://read.qxmd.com/read/38447660/establishment-of-a-patient-specific-avatar-organoid-model-derived-from-endoscopic-ultrasonography-guided-fine-needle-biopsy-for-timely-clinical-application-in-pancreatic-ductal-adenocarcinoma
#8
JOURNAL ARTICLE
Hyemin Kim, Jinho Jang, Jin Ho Choi, Joo Hye Song, Su Hyun Lee, Jiho Park, Si Kyong Ryoo, Eun Mi Lee, Hyoung-Oh Jeong, Seunghoon Kim, Se-Hoon Lee, Kwang Hyuck Lee, Kyu Taek Lee, Kyoung Mee Kim, Kee-Taek Jang, Hyunsook Lee, Semin Lee, Jong Kyun Lee, Joo Kyung Park
BACKGROUND AND AIMS: Pancreatic ductal adenocarcinoma (PDAC) has the worst survival rate among tumors. At the time of diagnosis, over 80 percent of PDACs are considered surgically unresectable, and there is an unmet need for treatment options in these inoperable PDACs. The study aimed to establish a patient-derived organoid (PDO) platform from endoscopic ultrasound-guided fine needle biopsy (EUS-FNB) collected at diagnosis and to determine its clinical applicability for the timely treatment of unresectable PDAC...
March 4, 2024: Gastrointestinal Endoscopy
https://read.qxmd.com/read/38438557/scleral-buckling-with-adjuvant-pneumatic-retinopexy-versus-scleral-buckling-alone-for-rhegmatogenous-retinal-detachment
#9
JOURNAL ARTICLE
Young Hoon Jung, Kyu Hyung Park, Se Joon Woo, Kwangsic Joo, Min Seok Kim
To compare the efficacy of scleral buckling with adjuvant pneumatic retinopexy (SB with PR) and scleral buckling (SB) alone for primary rhegmatogenous retinal detachment (RRD). This retrospective and comparative study included patients who underwent SB with PR (n = 88) or SB alone (n = 161) for primary RRD. The primary anatomical success rate for SB with PR was 81.8%, whereas that for SB alone was 80.7% (P = 0.836). Among patients who achieved primary anatomical success, those in the SB with PR group showed postoperative epiretinal membrane (ERM) formation more frequently than those in the SB alone group (11 of 72 [15...
March 4, 2024: Scientific Reports
https://read.qxmd.com/read/38433066/bleeding-after-endoscopic-papillectomy-and-its-risk-factors-a-single-center-experience-of-196-cases
#10
JOURNAL ARTICLE
Jin Ho Choi, Won Chul Kim, Joo Kyung Park, Jong Kyun Lee, Kyu Taek Lee, Kwang Hyuck Lee
BACKGROUND: Endoscopic papillectomy (EP) is an effective method to remove an ampulla of Vater (AoV) adenoma with minimal invasiveness. We reviewed the clinical outcomes and prognosis of patients undergoing EP, including tumor recurrence and adverse events. METHODS: A total of 196 patients who underwent EP from January 2004 to December 2017 were included. Clinical information was collected through electronic medical records, and risk factors to predict post-procedural bleeding were analyzed using a multivariate logistic regression model...
February 20, 2024: Hepatobiliary & Pancreatic Diseases International: HBPD INT
https://read.qxmd.com/read/38419334/current-evidence-for-prognostic-benefit-of-intravascular-imaging-guided-percutaneous-coronary-intervention-in-chronic-total-occlusion-intervention
#11
JOURNAL ARTICLE
David Hong, Sung Eun Kim, Seung Hun Lee, Seung-Jae Lee, Jong-Young Lee, Sang Min Kim, Sang Yeub Lee, Woochan Kwon, Ki Hong Choi, Taek Kyu Park, Jeong Hoon Yang, Young Bin Song, Seung-Hyuk Choi, Hyeon-Cheol Gwon, Joo-Yong Hahn, Joo Myung Lee
Although percutaneous coronary intervention (PCI) for chronic total occlusion (CTO) has been increasing in recent years, CTO PCI is still one of the most challenging procedures with relatively higher rates of procedural complications and adverse clinical events after PCI. Due to the innate limitations of invasive coronary angiography, intravascular imaging (IVI) has been used as an adjunctive tool to complement PCI, especially in complex coronary artery disease. Considering the complexity of CTO lesions, the role of IVI is particularly important in CTO intervention...
February 29, 2024: Korean Journal of Internal Medicine
https://read.qxmd.com/read/38413342/multicentre-validation-of-a-machine-learning-model-for-predicting-respiratory-failure-after-noncardiac-surgery
#12
JOURNAL ARTICLE
Hyun-Kyu Yoon, Hyun Joo Kim, Yi-Jun Kim, Hyeonhoon Lee, Bo Rim Kim, Hyongmin Oh, Hee-Pyoung Park, Hyung-Chul Lee
BACKGROUND: Postoperative respiratory failure is a serious complication that could benefit from early accurate identification of high-risk patients. We developed and validated a machine learning model to predict postoperative respiratory failure, defined as prolonged (>48 h) mechanical ventilation or reintubation after surgery. METHODS: Easily extractable electronic health record (EHR) variables that do not require subjective assessment by clinicians were used...
February 26, 2024: British Journal of Anaesthesia
https://read.qxmd.com/read/38412042/optimal-bilayer-composites-for-temperature-tracking-wireless-electronics
#13
JOURNAL ARTICLE
Doyoung Kim, Wooseok Kim, Jihwan Kim, Hee Kyu Lee, Janghoon Joo, Bogeun Kim, Mark G Allen, Dengyang Lu, Vishal Venkatesh, Yanghang Huang, Ki Jun Yu, Young-Jin Park, Mu Kyung Kim, Seungyong Han, Sang Min Won
Modern silicone-based epidermal electronics engineered for body temperature sensing represent a pivotal development in the quest for advancing preventive medicine and enhancing post-surgical monitoring. While these compact and highly flexible electronics empower real-time monitoring in dynamic environments, a noteworthy limitation is the challenge in regulating the infiltration or obstruction of heat from the external environment into the surface layers of these electronics. The study presents a cost-effective temperature sensing solution by embedding wireless electronics in a multi-layered elastomeric composite to meet the dual needs of enhanced thermal insulation for encapsulation in contact with air and improved thermal conductivity for the substrate in contact with the skin...
February 27, 2024: Nanoscale
https://read.qxmd.com/read/38394205/long-lasting-forms-of-plasticity-through-patterned-ultrasound-induced-brainwave-entrainment
#14
JOURNAL ARTICLE
Ho-Jeong Kim, Tien Thuy Phan, Keunhyung Lee, Jeong Sook Kim, Sang-Yeong Lee, Jung Moo Lee, Jongrok Do, Doyun Lee, Sung-Phil Kim, Kyu Pil Lee, Jinhyoung Park, C Justin Lee, Joo Min Park
Achieving long-lasting neuronal modulation with low-intensity, low-frequency ultrasound is challenging. Here, we devised theta burst ultrasound stimulation (TBUS) with gamma bursts for brain entrainment and modulation of neuronal plasticity in the mouse motor cortex. We demonstrate that two types of TBUS, intermittent and continuous TBUS, induce bidirectional long-term potentiation or depression-like plasticity, respectively, as evidenced by changes in motor-evoked potentials. These effects depended on molecular pathways associated with long-term plasticity, including N -methyl-d-aspartate receptor and brain-derived neurotrophic factor/tropomyosin receptor kinase B activation, as well as de novo protein synthesis...
February 23, 2024: Science Advances
https://read.qxmd.com/read/38391108/clinical-characteristics-of-persistent-postural-perceptual-dizziness-and-its-visual-subtype-in-korean-patients-a-multicenter-cross-sectional-study
#15
JOURNAL ARTICLE
Joo Hyun Park, Thanh Tin Nguyen, Sung-Hee Kim, Ji-Yun Park, Seunghee Na, Eun-Ju Jeon, Ji Won Seo, Chang Gun Cho, Se-Joon Oh, Sung-Won Choi, Kwang-Dong Choi, Seo-Young Choi, Ji Eun Choi, Sung-Kwang Hong, Won-Ho Chung, Young Sang Cho, Hwan Ho Lee, Yong-Hwi An, Kyu-Hee Han, Hyung Lee, Hyun Ah Kim, Ho Yun Lee, Jong-Dae Lee, Se A Lee, Sun-Young Oh
OBJECTIVES: Persistent postural-perceptual dizziness (PPPD) is a chronic functional vestibular disorder for which the Bárány Society has established diagnostic criteria. This nationwide multicenter study aims to investigate the clinical features of individuals with definite PPPD and clinical variant PPPD who do not fully meet the diagnostic criteria, with a particular focus on visual exaggeration. METHODS: Between September 2020 and September 2021, a total of 76 individuals with definite PPPD and 109 individuals with clinical variant PPPD who did not meet all three exacerbating factors outlined in Criterion B were recruited from 18 medical centers in South Korea...
February 2024: Brain and Behavior
https://read.qxmd.com/read/38381945/the-association-of-the-sequential-organ-failure-assessment-score-at-intensive-care-unit-discharge-with-intensive-care-unit-readmission-in-the-cardiac-intensive-care-unit
#16
JOURNAL ARTICLE
Yonghoon Shin, Ji Hoon Jang, Ryoung-Eun Ko, Soo Jin Na, Chi Ryang Chung, Ki Hong Choi, Taek Kyu Park, Joo Myung Lee, Jeong Hoon Yang
AIMS: Unplanned intensive care unit (ICU) readmissions contribute to increased morbidity, mortality, and healthcare costs. The severity of patient illness at ICU discharge may predict early ICU readmission. Thus, in this study, we investigated the association of cardiac ICU (CICU) discharge Sequential Organ Failure Assessment (SOFA) score with unplanned CICU readmission in patients admitted to the CICU. METHODS AND RESULTS: We retrospectively reviewed the hospital medical records of 4659 patients who were admitted to the CICU from 2012 to 18...
February 21, 2024: European Heart Journal. Acute Cardiovascular Care
https://read.qxmd.com/read/38367259/donor-fat-to-muscle-ratio-and-kidney-transplant-outcomes-a%C3%A2-proposition-of-metabolic-memory
#17
JOURNAL ARTICLE
Youn Kyung Kee, Juhan Lee, Bo Young Nam, Young Su Joo, Shin-Wook Kang, Kyu Ha Huh, Jung Tak Park
AIMS: The impact of donor abdominal fat-to-muscle ratio (FMR) on kidney transplant (KT) outcomes was assessed. Given the transient nature of the donor's metabolic environment in transplant recipients, this study investigated the capacity of body composition to induce metabolic memory effects. MATERIALS AND METHODS: KT patients (n = 895) who received allografts from living donors (2003-2013) were included. Donor fat and muscle were quantified using pre-KT abdominal computed tomography scans...
February 2024: Diabetes/metabolism Research and Reviews
https://read.qxmd.com/read/38338338/stat3-decoy-oligodeoxynucleotides-suppress-liver-inflammation-and-fibrosis-in-liver-cancer-cells-and-a-ddc-induced-liver-injury-mouse-model
#18
JOURNAL ARTICLE
Hye Jin Choi, Young-Ah Kim, Junghwa Ryu, Kwan-Kyu Park, Sun-Jae Lee, Byung Seok Kim, Jeong-En Song, Joo Dong Kim
Liver damage caused by various factors results in fibrosis and inflammation, leading to cirrhosis and cancer. Fibrosis results in the accumulation of extracellular matrix components. The role of STAT proteins in mediating liver inflammation and fibrosis has been well documented; however, approved therapies targeting STAT3 inhibition against liver disease are lacking. This study investigated the anti-fibrotic and anti-inflammatory effects of STAT3 decoy oligodeoxynucleotides (ODN) in hepatocytes and liver fibrosis mouse models...
January 25, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38331894/unraveling-the-role-of-the-mitochondrial-one-carbon-pathway-in-undifferentiated-thyroid-cancer-by-multi-omics-analyses
#19
JOURNAL ARTICLE
Seong Eun Lee, Seongyeol Park, Shinae Yi, Na Rae Choi, Mi Ae Lim, Jae Won Chang, Ho-Ryun Won, Je Ryong Kim, Hye Mi Ko, Eun-Jae Chung, Young Joo Park, Sun Wook Cho, Hyeong Won Yu, June Young Choi, Min-Kyung Yeo, Boram Yi, Kijong Yi, Joonoh Lim, Jun-Young Koh, Min Jeong Lee, Jun Young Heo, Sang Jun Yoon, Sung Won Kwon, Jong-Lyul Park, In Sun Chu, Jin Man Kim, Seon-Young Kim, Yujuan Shan, Lihua Liu, Sung-A Hong, Dong Wook Choi, Junyoung O Park, Young Seok Ju, Minho Shong, Seon-Kyu Kim, Bon Seok Koo, Yea Eun Kang
The role of the serine/glycine metabolic pathway (SGP) has recently been demonstrated in tumors; however, the pathological relevance of the SGP in thyroid cancer remains unexplored. Here, we perform metabolomic profiling of 17 tumor-normal pairs; bulk transcriptomics of 263 normal thyroid, 348 papillary, and 21 undifferentiated thyroid cancer samples; and single-cell transcriptomes from 15 cases, showing the impact of mitochondrial one-carbon metabolism in thyroid tumors. High expression of serine hydroxymethyltransferase-2 (SHMT2) and methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) is associated with low thyroid differentiation scores and poor clinical features...
February 8, 2024: Nature Communications
https://read.qxmd.com/read/38330380/therapeutic-effects-of-surgical-debulking-of-metastatic-lymph-nodes-in-cervical-cancer-iiicr-a-trial-protocol-for-a-phase-iii-multicenter-randomized-controlled-study-kgog1047-debulk-trial
#20
JOURNAL ARTICLE
Bo Seong Yun, Kwang-Beom Lee, Keun Ho Lee, Ha Kyun Chang, Joo-Young Kim, Myong Cheol Lim, Chel Hun Choi, Hanbyoul Cho, Dae-Yeon Kim, Yun Hwan Kim, Joong Sub Choi, Chae Hyeong Lee, Jae-Weon Kim, Sang Wun Kim, Yong Bae Kim, Chi-Heum Cho, Dae Gy Hong, Yong Jung Song, Seob Jeon, Min Kyu Kim, Dae Hoon Jeong, Hyun Park, Seok Mo Kim, Sang-Il Park, Jae-Yun Song, Asima Mukhopadhyay, Dang Huy Quoc Thinh, Nirmala Chandralega Kampan, Grace J Lee, Jae-Hoon Kim, Keun-Yong Eom, Ju-Won Roh
BACKGROUND: Bulky or multiple lymph node (LN) metastases are associated with poor prognosis in cervical cancer, and the size or number of LN metastases is not yet reflected in the staging system and therapeutic strategy. Although the therapeutic effects of surgical resection of bulky LNs before standard treatment have been reported in several retrospective studies, well-planned randomized clinical studies are lacking. Therefore, the aim of the Korean Gynecologic Oncology Group (KGOG) 1047/DEBULK trial is to investigate whether the debulking surgery of bulky or multiple LNs prior to concurrent chemoradiation therapy (CCRT) improves the survival rate of patients with cervical cancer IIICr diagnosed by imaging tests...
January 22, 2024: Journal of Gynecologic Oncology
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