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https://www.readbyqxmd.com/read/28738253/size-distribution-and-elastic-properties-of-thermo-responsive-polymer-gel-microparticles-in-suspension-probed-by-ultrasonic-spectroscopy
#1
Takehisa Inoue, Tomohisa Norisuye, Kazuki Sugita, Hideyuki Nakanishi, Qui Tran-Cong-Miyata
The size distribution and the elasticity of thermo-responsive gel particles dispersed in water were examined in-situ by ultrasonic spectroscopy (US). Poly(N-isopropylacrylamide) (PNIPAM) gel particles, undergoing volume phase transition at 34°C were synthesized by redox polymerization in emulsion, and the temperature dependence of the acoustic properties was examined. The longitudinal velocity and the attenuation coefficient of particle exhibited a drastic change at the transition temperature, indicating the increase in the mechanical properties, such the longitudinal, bulk and shear moduli, due to the shrinkage of particles upon temperature stimulation...
July 14, 2017: Ultrasonics
https://www.readbyqxmd.com/read/28738008/randomized-placebo-controlled-study-of-the-effects-of-yunnan-baiyao-on-hemostasis-in-horses
#2
SallyAnne L Ness, Amelia H Frye, Thomas J Divers, Mark Rishniw, Hollis N Erb, Marjory B Brooks
OBJECTIVE To determine effects of oral administration of Yunnan Baiyao on platelet activation, coagulation, and fibrinolysis in healthy horses. ANIMALS 12 healthy adult horses. PROCEDURES In a randomized blinded crossover study that included a 4-week washout period between treatments, horses were orally administered a paste containing Yunnan Baiyao (15 mg/kg) or placebo at 12-hour intervals for 3 days. Blood samples were collected before start of treatment (time 0) and at 24 and 72 hours for a CBC, measurement of fibrinogen concentration, coagulation screening tests, and a panel of assays to assess platelet activation (including ADP- and collagen-induced aggregation and closure times, flow-cytometric variables of platelet-leukocyte aggregates, platelet membrane P-selectin and phosphatidylserine expression, and microparticle release), von Willebrand factor (vWF) concentration, and cofactor activity...
August 2017: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/28737691/coagulopathy-in-the-setting-of-mild-traumatic-brain-injury-truths-and-consequences
#3
REVIEW
Joseph P Herbert, Andrew R Guillotte, Richard D Hammer, N Scott Litofsky
Mild traumatic brain injury (mTBI) is a common, although poorly-defined clinical entity. Despite its initially mild presentation, patients with mTBI can rapidly deteriorate, often due to significant expansion of intracranial hemorrhage. TBI-associated coagulopathy is the topic of significant clinical and basic science research. Unlike trauma-induced coagulopathy (TIC), TBI-associated coagulopathy does not generally follow widespread injury or global hypoperfusion, suggesting a distinct pathogenesis. Although the fundamental mechanisms of TBI-associated coagulopathy are far from clearly elucidated, several candidate molecules (tissue plasminogen activator (tPA), urokinase plasminogen activator (uPA), tissue factor (TF), and brain-derived microparticles (BDMP)) have been proposed which might explain how even minor brain injury can induce local and systemic coagulopathy...
July 22, 2017: Brain Sciences
https://www.readbyqxmd.com/read/28736613/cd200-modulates-macrophage-cytokine-secretion-and-phagocytosis-in-response-to-poly-lactic-co-glycolic-acid-microparticles-and-films
#4
E Y Chen, S Chu, L Gov, Y K Kim, M B Lodoen, A J Tenner, W F Liu
Biocompatibility is a major concern for developing biomaterials used in medical devices, tissue engineering and drug delivery. Poly(lactic-co-glycolic acid) (PLGA) is one of the most widely used biodegradable materials, yet still triggers a significant foreign body response that impairs healing. Immune cells including macrophages respond to the implanted biomaterial and mediate the host response, which can eventually lead to device failure. Previously in our laboratory, we found that CD200, an immunomodulatory protein, suppressed macrophage inflammatory activation in vitro and reduced local immune cell infiltration around a biomaterial implant...
February 28, 2017: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://www.readbyqxmd.com/read/28732936/oxygen-and-indocyanine-green-loaded-microparticles-for-dual-mode-imaging-and-sonodynamic-treatment-of-cancer-cells
#5
Rong Ma, Qiang Wu, Ting Si, Shufang Chang, Ronald X Xu
Oxygen and Indocyanine Green (ICG) loaded microparticles (OI-MPs) were fabricated by a gas-driven coaxial flow focusing (CFF) process for dual-mode imaging and sonodynamic therapy (SDT). The produced OI-MPs agent showed stable optical properties, superior imaging depth in near infrared (NIR) fluorescence imaging, and enhanced acoustic contrast after ultrasound mediation. We hypothesized that encapsulating ICG and oxygen in microparticles would enhance reactive oxygen species (ROS) production in SDT. This hypothesis was validated in a cell-free environment...
November 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28732440/intravenous-injection-of-myelin-oligodendrocyte-glycoprotein-coated-plga-microparticles-have-tolerogenic-effects-in-experimental-autoimmune-encephalomyelitis
#6
Mehrdad Gholamzad, Masoumeh Ebtekar, Mehdi Shafiee Ardestani
The abnormal function of the T lymphocytes causes a range of autoimmune diseases, particularly multiple sclerosis; hence, several methods have been used to treat these disorders through the induction of antigen-specific tolerance in T cells. The present study aims to use a simple and low-cost method to produce poly (lactic-co-glycolic acid) (PLGA) nanoparticles for carrying antigens and inducing antigen-specific tolerance. In this study, PLGA nanoparticles were produced using the water/oil/water (W/O/W) method...
June 2017: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/28731155/marine-collagen-peptides-reduce-endothelial-cell-injury-in-diabetic-rats-by-inhibiting-apoptosis-and-the-expression-of-coupling-factor-6-and-microparticles
#7
Cuifeng Zhu, Wei Zhang, Jianguo Liu, Bo Mu, Fan Zhang, Nannan Lai, Jianxin Zhou, Aimin Xu, Yong Li
The present study aimed to elucidate the role of marine collagen peptides (MCPs) in protection of carotid artery vascular endothelial cells (CAVECs) in type 2 diabetes mellitus (T2DM), and the mechanism underlying this process. In an in vivo experiment, diabetic Wistar rats were divided randomly into four groups (n=10/group): Diabetes control, and three diabetes groups administered low, medium and high doses of MCPs (2.25, 4.5 and 9.0 g/kg body weight/day, respectively). Another 10 healthy rats served as the control...
July 21, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28729506/highly-elastic-binders-integrating-polyrotaxanes-for-silicon-microparticle-anodes-in-lithium-ion-batteries
#8
Sunghun Choi, Tae-Woo Kwon, Ali Coskun, Jang Wook Choi
Lithium-ion batteries with ever-increasing energy densities are needed for batteries for advanced devices and all-electric vehicles. Silicon has been highlighted as a promising anode material because of its superior specific capacity. During repeated charge-discharge cycles, silicon undergoes huge volume changes. This limits cycle life via particle pulverization and an unstable electrode-electrolyte interface, especially when the particle sizes are in the micrometer range. We show that the incorporation of 5 weight % polyrotaxane to conventional polyacrylic acid binder imparts extraordinary elasticity to the polymer network originating from the ring sliding motion of polyrotaxane...
July 21, 2017: Science
https://www.readbyqxmd.com/read/28726548/wnt-yap-interactions-during-neural-tissue-patterning-of-human-induced-pluripotent-stem-cells
#9
Julie Bejoy, Liqing Song, Yi Zhou, Yan Li
Human induced pluripotent stem cells (hiPSCs) have special ability to self-assemble into neural spheroids or mini-brain like structures. During the self-assembly process, Wnt signaling plays an important role in regional patterning and establishing positional identity of hiPSC-derived neural progenitors. Recently, the role of Wnt signaling in regulating Yes-associated protein (YAP) expression (nuclear or cytoplasmic), the pivotal regulator during organ growth and tissue generation, has attracted increasing interests...
July 20, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28726381/impact-of-the-metallic-crystalline-structure-on-the-properties-of-nanocrystals-and-their-mesoscopic-assemblies
#10
Marie-Paule Pileni
The spontaneous assembly of uniform-sized globular entities into ordered arrays is a universal phenomenon observed for objects with diameters spanning a broad range of length scales. These extend from the atomic scale (10(-8) cm), through molecular and macromolecular scales with proteins, synthetic low polymers, and colloidal crystals (∼10(-6) cm), to the wavelength of visible light (∼10(-5) cm). The associated concepts of sphere packing have had an influence in diverse fields ranging from pure geometrical analysis to architectural models or ideals...
July 20, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28726349/aspherical-nanostructured-microparticles-for-targeted-gene-delivery-to-alveolar-macrophages
#11
Michael Möhwald, Shashank Reddy Pinnapireddy, Bodo Wonnenberg, Marcel Pourasghar, Marijas Jurisic, Andrea Jung, Claudia Fink-Straube, Thomas Tschernig, Udo Bakowsky, Marc Schneider
Introducing novel shapes to particulate carrier systems adds unique features to modern drug and gene delivery. Depending on the route of administration, particle geometry can influence deposition and fate within biological environments. In this work, a template-assisted engineering technique is applied, providing full control of size and shape in the preparation of aspherical, nanostructured microparticles. Based on the interconnection of nanoparticles, stabilized by a functional layer-by-layer (LbL) coating, the resulting cylindrical micrometer architecture is especially qualified for pulmonary delivery...
July 20, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28725884/an-enzyme-mediated-competitive-colorimetric-sensor-based-on-au-ag-bimetallic-nanoparticles-for-highly-sensitive-detection-of-disease-biomarkers
#12
Binfeng Yin, Wenshu Zheng, Mingling Dong, Wenbo Yu, Yiping Chen, Sang Woo Joo, Xingyu Jiang
We developed a competitive colorimetric nanosensor based on Au@Ag bimetallic nanoparticles for the detection of interleukin-6 (IL-6) in clinical samples. Antibody-conjugated magnetic nanoparticles (MNPs) and polystyrene (PS) microparticles conjugated with both catalase and a secondary antibody can form sandwich structures that enable one-step target enrichment and separation. The catalase on the surface of the PS can catalyze the hydrolysis of hydrogen peroxide (H2O2) to regulate the deposition of Ag(+) on the surface of gold nanoparticles (AuNPs), and forms different sizes and amounts of Au@Ag bimetallic nanoparticles (Au@AgNPs) which produce a distinct color signal for readout with the naked eye...
July 20, 2017: Analyst
https://www.readbyqxmd.com/read/28724791/mitochondrial-dna-enriched-microparticles-promote-acute-on-chronic-alcoholic-neutrophilia-and-hepatotoxicity
#13
Yan Cai, Ming-Jiang Xu, Erik H Koritzinsky, Zhou Zhou, Wei Wang, Haixia Cao, Peter St Yuen, Ruth A Ross, Robert A Star, Suthat Liangpunsakul, Bin Gao
Over the last several years, one of the major advances in the field of alcoholic liver disease research was the discovery that binge alcohol consumption induced neutrophilia and hepatic neutrophil infiltration in chronically ethanol-fed mice and human subjects with excessive alcohol use (EAU); however, the underlying mechanisms remain obscure. Here, we demonstrated that chronic EAU patients with a history of recent excessive drinking (EAU + RD) had higher serum levels of mitochondrial DNA (mtDNA)-enriched microparticles (MPs) than EAU without recent drinking (EAU - RD) and healthy controls, which correlated positively with circulating neutrophils...
July 20, 2017: JCI Insight
https://www.readbyqxmd.com/read/28722448/chemical-sensing-on-a-single-sers-particle
#14
Ying Ma, Kittithat Promthaveepong, Nan Li
We report a new chemical sensing platform on a single surface-enhanced Raman scattering (SERS) particle. A cabbage-like Au microparticle (CLMP) with high SERS enhancement was applied as an ultrasensitive SERS substrate. A new Raman reporter bis[4,4'-[dithiodiphenyl azo-phenol] (DTDPAP) was synthesized to display multiple fingerprints and high reactivity toward sodium dithionite. The reaction of DTDPAP with sodium dithionite was in situ monitored by SERS on a single CLMP. The DTDPAP fingerprint change is dependent on the sodium dithionite concentration, providing a simple and sensitive method for sodium dithionite profiling...
January 27, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28720779/mimicking-paracrine-tgf%C3%AE-1-signals-during-myofibroblast-differentiation-in-3d-collagen-networks
#15
Michael Ansorge, Jiranuwat Sapudom, Marina Chkolnikov, Martin Wilde, Ulf Anderegg, Stephanie Möller, Matthias Schnabelrauch, Tilo Pompe
TGFβ1 is a key regulator for induction of tissue remodeling after dermal wounding. We present a model of paracrine delivery of TGFβ1 for differentiation of dermal fibroblasts based on a fibrillar 3D collagen matrix and embedded TGFβ1 releasing microparticles. We found differentiation into myofibroblasts was achieved in a TGFβ1 dependent manner at much lower doses than systemic delivery. This effect is accounted to the slow and sustained TGFβ1 release mimicking paracrine cell signals.
July 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28719175/a-simple-cleated-dna-walker-that-hangs-on-to-surfaces
#16
Cheulhee Jung, Peter B Allen, Andrew D Ellington
We designed and demonstrated a single-legged or unipedal walker that has a "cleat" that allows it to persistently associate with a track and make autonomous decisions about movement. The walker is highly processive over long periods of time, as shown by its movement over a microparticle surface suffused with substrate. The simple design can be readily optimized on the basis of simple energetic considerations. The walker can be used for signal amplification and should prove especially valuable for programming amorphous computations within chemical reaction networks...
July 18, 2017: ACS Nano
https://www.readbyqxmd.com/read/28718695/enhanced-procoagulant-activity-of-platelets-after-chemotherapy-in-non-small-cell-lung-cancer
#17
Ruishuang Ma, Yayan Bi, Junjie Kou, Jin Zhou, Jialan Shi
The procoagulant status of patients with non-small cell lung cancer (NSCLC) after chemotherapy is poorly characterized and the role of platelets in hypercoagulative state of NSCLC is unknown. The aim of this study was to evaluate the procoagulant activity (PCA) of platelets in NSCLC before and after chemotherapy. The subjects were 52 patients newly diagnosed with NSCLC. The patients had decreased clotting time compared with healthy subjects, and the thrombin-antithrombin complex increased 2.5 fold after chemotherapy...
July 18, 2017: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/28718063/new-insights-on-platelets-and-platelet-derived-microparticles-in-systemic-lupus-erythematosus
#18
REVIEW
Marc Scherlinger, Vanja Sisirak, Christophe Richez, Estibaliz Lazaro, Pierre Duffau, Patrick Blanco
PURPOSE OF REVIEW: Current knowledge on the role of platelets and platelet-derived microparticles (PMPs) on the immune system has been fast-growing. Systemic lupus erythematosus (SLE) is a systemic auto-immune disorder characterized by a loss of tolerance toward nuclear auto-antigens. Although recent studies allowed a better understanding of SLE pathogenesis, there is an urgent need for the development of new treatments and the identification of new biomarkers to assess the disease activity...
August 2017: Current Rheumatology Reports
https://www.readbyqxmd.com/read/28717506/injectable-scaffold-materials-differ-in-their-cell-instructive-effects-on-primary-human-myoblasts
#19
Eva Kildall Hejbøl, Jeeva Sellathurai, Prabha Damodaran Nair, Henrik Daa Schrøder
Scaffolds are materials used for delivery of cells for regeneration of tissues. They support three-dimensional organization and improve cell survival. For the repair of small skeletal muscles, injections of small volumes of cells are attractive, and injectable scaffolds for delivery of cells offer a minimally invasive technique. In this study, we examined in vitro the cell instructive effects of three types of injectable scaffolds, fibrin, alginate, and poly(lactic-co-glycolic acid)-based microparticles on primary human myoblasts...
January 2017: Journal of Tissue Engineering
https://www.readbyqxmd.com/read/28717186/overstepping-the-upper-refractive-index-limit-to-form-ultra-narrow-photonic-nanojets
#20
Guoqiang Gu, Jun Song, Hongda Liang, Mengjie Zhao, Yue Chen, Junle Qu
In general, photonic nanojets (PNJs) occur only when the refractive index (Ri) difference between the microparticle and background media is less than 2. The minimum full width at half-maximum (FWHM) of the PNJ is ~130 nm (approximately one-third of the illumination wavelength λ = 400 nm) formed within the evanescent field region. This paper proposes and studies a method to overstep the Ri upper bound and generate ultra-narrow PNJs. Finite element method based numerical investigations and ray-optics theoretical analyses have realized ultra-narrow PNJs with FWHM as small as 114...
July 17, 2017: Scientific Reports
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