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https://www.readbyqxmd.com/read/28106155/secreted-mir-27a-induced-by-cyclic-stretch-modulates-the-proliferation-of-endothelial-cells-in-hypertension-via-grk6
#1
Lu Wang, Han Bao, Kai-Xuan Wang, Ping Zhang, Qing-Ping Yao, Xiao-Hu Chen, Kai Huang, Ying-Xin Qi, Zong-Lai Jiang
Abnormal proliferation of endothelial cells (ECs) is important in vascular remodeling during hypertension, but the mechanisms are still unclear. In hypertensive rats caused by abdominal aortic coarctation, the expression of G-protein-coupled receptor kinase 6 (GRK6) in ECs at common carotid artery was repressed in vivo, and EC proliferation was increased. 15% cyclic stretch in vitro, which mimics the pathologically increased stretch in hypertension, repressed EC GRK6 expression via paracrine control by vascular smooth muscle cells (VSMCs)...
January 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28103286/mirnas-do-not-regulate-circadian-protein-synthesis-in-the-dinoflagellate-lingulodinium-polyedrum
#2
Steve Dagenais-Bellefeuille, Mathieu Beauchemin, David Morse
Dinoflagellates have been shown to express miRNA by bioinformatics and RNA blot (Northern) analyses. However, it is not yet known if miRNAs are able to alter gene expression in this class of organisms. We have assessed the possibility that miRNA may mediate circadian regulation of gene expression in the dinoflagellate Lingulodinium polyedrum using the Luciferin Binding Protein (LBP) as a specific example. LBP is a good candidate for regulation by miRNA since mRNA levels are constant over the daily cycle while protein synthesis is restricted by the circadian clock to a period of several hours at the start of the night phase...
2017: PloS One
https://www.readbyqxmd.com/read/28102766/soluble-p-selectin-rescues-mice-from-anthrax-lethal-toxin-induced-mortality-through-psgl-1-pathway-mediated-correction-of-hemostasis
#3
Der-Shan Sun, Yao-Wen Chang, Jyh-Hwa Kau, Hsin-Hsien Huang, Pei-Hsun Ho, Yin-Jeh Tzeng, Hsin-Hou Chang
As one of the virulence factors of Bacillus anthracis, lethal toxin (LT) induces various pathogenic responses including the suppression of the coagulation system. In this study, we observed that LT markedly increased the circulating soluble P-selectin (sP-sel) levels and microparticle (MP) count in wild-type but not P-selectin (P-sel, Selp(-)(-)(-)) or P-sel ligand-1 (PSGL-1, Selplg(-)(-)(-)) knockout mice. Because sP-sel induces a hypercoagulable state through PSGL-1 pathway to generate tissue factor-positive MPs, we hypothesized that the increase in plasma sP-sel levels can be a self-rescue response in hosts against the LT-mediated suppression of the coagulation system...
January 19, 2017: Virulence
https://www.readbyqxmd.com/read/28102737/platelet-microvesicles-in-health-and-disease
#4
Imene Melki, Nicolas Tessandier, Anne Zufferey, Eric Boilard
Interest in cell-derived extracellular vesicles and their physiological and pathological implications is constantly growing. Microvesicles, also known as microparticles, are small extracellular vesicles released by cells in response to activation or apoptosis. Among the different microvesicles present in the blood of healthy individuals, platelet-derived microvesicles (PMVs) are the most abundant. Their characterization has revealed a heterogeneous cargo that includes a set of adhesion molecules. Similarly to platelets, PMVs are also involved in thrombosis through support of the coagulation cascade...
January 19, 2017: Platelets
https://www.readbyqxmd.com/read/28101538/recent-advances-in-engineering-microparticles-and-their-nascent-utilization-in-biomedical-delivery-and-diagnostic-applications
#5
REVIEW
Andrew Choi, Kyoung Duck Seo, Do Wan Kim, Bum Chang Kim, Dong Sung Kim
Complex microparticles (MPs) bearing unique characteristics such as well-tailored sizes, various morphologies, and multi-compartments have been attempted to be produced by many researchers in the past decades. However, a conventionally used method of fabricating MPs, emulsion polymerization, has a limitation in achieving the aforementioned characteristics and several approaches such as the microfluidics-assisted (droplet-based microfluidics and flow lithography-based microfluidics), electrohydrodynamics (EHD)-based, centrifugation-based, and template-based methods have been recently suggested to overcome this limitation...
January 17, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28099427/exposure-to-bisphenols-and-phthalates-and-association-with-oxidant-stress-insulinn-resistance-and-endothelial-dysfunction-in-children
#6
Anglina Kataria, Dov Levine, Sara Wertenteil, Suzanne Vento, Jingchuan Xue, Karthikraj Rajendiran, Kurunthachalam Kannan, Joshua M Thurman, Debra Morrison, Rachel Brody, Elaine Urbina, Teresa Attina, Leonardo Trasande, Howard Trachtman
BACKGROUND: The health effects of bisphenol A (BPA) and di-(2-ethylhexyl) phthalate (DEHP) have been studied extensively in children. The impact of other chemicals in these two classes has not been investigated as fully. METHODS: We conducted a cross-sectional pilot study of 10-13 year old healthy children. We assessed descriptive, univariable and multivariable associations of urinary metabolites of bisphenols and phthalates with oxidant stress, insulin resistance, body mass, and endothelial dysfunction...
January 18, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28099120/the-clinical-significance-of-platelet-microparticle-associated-micrornas
#7
Patrick Provost
Circulating blood platelets play a central role in the maintenance of hemostasis. They adhere to subendothelial extracellular matrix proteins that become exposed upon vessel wall damage, which is followed by platelet activation, further platelet recruitment, platelet aggregation and formation of an occlusive, or non-occlusive, platelet thrombus. Platelets host a surprisingly diverse transcriptome, which is comprised of ~9500 messenger RNAs (mRNAs) and different classes of non-coding RNAs, including microRNAs, as well as a significant repertoire of proteins that contribute to their primary (adhesion, aggregation, granule secretion) and alternative (RNA transfer, mRNA translation, immune regulation) functions...
January 18, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28098968/functional-microcapsules-via-thiol-ene-photopolymerization-in-droplet-based-microfluidics
#8
Douglas V Amato, Hyomin Lee, Jörg G Werner, David A Weitz, Derek L Patton
Thiol-ene chemistry was exploited in droplet-based microfluidics to fabricate advanced microcapsules with tunable encapsulation, degradation, and thermal properties. In addition, by utilizing the thiol-ene photopolymerization with tunable cross-link density, we demonstrate the importance of monomer conversion on the retention of omniphilic cargo in double emulsion templated microcapsules. Furthermore, we highlight the rapid cure kinetics afforded by thiol-ene chemistry in a continuous flow photopatterning device for hemispherical microparticle production...
January 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28098900/endothelial-microparticles-activate-endothelial-cells-to-facilitate-the-inflammatory-response
#9
Yiyun Liu, Ruyuan Zhang, Hongping Qu, Jun Wu, Lei Li, Yaoqing Tang
Endothelial microparticles (EMPs) and endothelial cells (ECs) are involved in the pathophysiological mechanisms of sepsis and septic shock. EMPs are small vesicles released by ECs and are considered biomarkers for endothelial cell function and mediators for intercellular information exchange. However, the effect of EMPs on their parental ECs remains unknown. The present study collected tumor necrosis factor‑α‑derived EMPs and detected the proinflammatory cytokines released from unstimulated and EMP‑stimulated ECs by proteome profiler array...
January 12, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28097040/effects-of-inhalable-microparticles-of-seonpyejeongcheon-tang-in-an-asthma-mouse-model-effects-of-microparticles-of-sjt
#10
Won-Kyung Yang, Chul-Hwa Lee, Min-Hee Kim, Seung-Hyeong Kim, Hae-Yoon Choi, Yoon Yeo, Yang-Chun Park
OBJECTIVES: Allergic asthma generally presents with symptoms of wheezing, coughing, breathlessness, and airway inflammation. Seonpyejeongcheon-tang (SJT) consists of 12 herbs. It originated from Jeongcheon-tang (JT), also known as Ding-chuan-tang, composed of 7 herbs, in She-sheng-zhong-miao-fang. This study aimed to evaluate the effects of local delivery of SJT via inhalable microparticles in an asthma mouse model. METHODS: Microparticles containing SJT were produced by spray-drying with leucine as an excipient...
December 2016: Journal of Pharmacopuncture
https://www.readbyqxmd.com/read/28092631/optoelectrofluidic-printing-system-for-fabricating-hydrogel-sheets-with-on-demand-patterned-cells-and-microparticles
#11
Hyun Ji Gi, Dongsik Han, Je-Kyun Park
This paper presents a novel optoelectrofluidic printing system that facilitates not only the optoelectrofluidic patterning of microparticles and mammalian cells but also the harvesting of the patterned microparticles encapsulated within poly(ethylene glycol) dicarylate (PEGDA) hydrogel sheets. Although optoelectrofluidic technology has numerous advantages for programmable and on-demand patterning and the feasibility of manipulating single microparticles, practical applications using existing laboratory infrastructure in biological and clinical research fields have been strictly restricted due to the impossibility of recovering the final patterned product...
January 16, 2017: Biofabrication
https://www.readbyqxmd.com/read/28089929/impact-of-immobilizing-of-low-molecular-weight-hyaluronic-acid-within-gelatin-based-hydrogel-through-enzymatic-reaction-on-behavior-of-enclosed-endothelial-cells
#12
Mehdi Khanmohammadi, Shinji Sakai, Masahito Taya
The hydrogels having the ability to promote migration and morphogenesis of endothelial cells (ECs) are useful for fabricating vascularized dense tissues in vitro. The present study explores the immobilization of low molecular weight hyaluronic acid (LMWHA) derivative within gelatin-based hydrogel to stimulate migration of ECs. The LMWHA derivative possessing phenolic hydroxyl moieties (LMWHA-Ph) was bound to gelatin-based derivative hydrogel through the horseradish peroxidase-catalyzed reaction. The motility of ECs was analyzed by scratch migration assay and microparticle-based cell migration assay...
January 12, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28089410/microparticle-detection-to-guide-platelet-management-for-the-reduction-of-platelet-refractoriness-in-children-a-study-proposal
#13
REVIEW
Peter Kanzler, Andrew Mahoney, Gerda Leitner, Volker Witt, Elisabeth Maurer-Spurej
Microparticles have been shown to shed from a variety of viable cells as a consequence of inflammatory processes, activation or physical stress. Seventy to 90% of circulating microparticles are thought to be platelet-derived. The content of microparticles in blood collected from normal blood donors is highly variable and transfers into the final blood component. Elevated microparticle content (MPC) in donor blood might indicate an asymptomatic clinical condition of the donor which might affect the transfusion recipient, particularly pediatric patients...
December 29, 2016: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28088464/microparticles-inflammatory-and-haemostaticbiomarkers-in-polycystic-ovary-syndrome
#14
L M L Carvalho, C N Ferreira, M O Sóter, M F Sales, K F Rodrigues, S R Martins, A L Candido, F M Reis, I O Silva, F M F Campos, K B Gomes
Polycystic Ovary Syndrome (PCOS) is associated with a chronic low-grade inflammation and predisposition to hemostatic and atherosclerotic complications. This case-control study evaluated the microparticles (MPs) profile in patients with the PCOS and related these MPs to clinical and biochemical parameters. MPs derived from platelets (PMPs), leuckocytes (LMPs) and endothelial cells (EMPs) were evaluated, as well as MPs expressing tissue factor (TFMPs), by flow cytometry, comparing women with PCOS (n = 50) and a healthy control group (n = 50)...
January 11, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28088371/a-quality-by-design-qbd-study-on-enoxaparin-sodium-loaded-polymeric-microspheres-for-colon-specific-delivery
#15
Dana Hales, Laurian Vlase, Sebastian Alin Porav, Andreea Bodoki, Lucian Barbu-Tudoran, Marcela Achim, Ioan Tomuță
The aim of this study was to apply quality by design (QbD) for pharmaceutical development of enoxaparin sodium microspheres for colon-specific delivery. The Process Parameters (CPPs) and Critical Quality Attributes (CQAs) were identified. A central composite experimental design was used in order to develop the design space of microspheres for colon-specific delivery that have the desired Quality Target Product Profile (QTPP). The CPPs studied were Eudragit® FS-30D/Eudragit® RS-PO ratio, poly(vinyl alcohol) (PVA) concentration and sodium chloride (NaCl) concentration...
January 11, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28088279/archaeometric-analysis-of-roman-bronze-coins-from-the-magna-mater-temple-using-solid-state-voltammetry-and-electrochemical-impedance-spectroscopy
#16
Francesca Di Turo, Noemí Montoya, Joan Piquero-Cilla, Caterina De Vito, Fulvio Coletti, Gabriele Favero, Antonio Doménech-Carbó
Voltammetry of microparticles (VMP) and electrochemical impedance spectroscopy (EIS) techniques, complemented by SEM-EDX and Raman spectroscopy, were applied to a set of 15 Roman bronze coins and one Tessera from the temple of Magna Mater (Rome, Italy). The archaeological site, dated back between the second half and the end of the 4th century A.D., presented a complicated stratigraphic context. Characteristic voltammetric patterns for cuprite and tenorite for sub-microsamples of the corrosion layers of the coins deposited onto graphite electrodes in contact with 0...
February 22, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28087355/generation-of-quercetin-cellulose-acetate-phthalate-systems-for-delivery-by-supercritical-antisolvent-process
#17
I García-Casas, A Montes, C Pereyra, E J Martínez de la Ossa
Supercritical antisolvent process (SAS) has been used to precipitate microparticles of quercetin, a plant pigment found in many foods and used for medical treatments, pharmaceutical and cosmetic industries, together with nanoparticles of cellulose acetate phthalate (CAP), a polymer quite frequently used in drug delivery. Previously, precipitation of nanoparticles of CAP by the same process was studied at different conditions of pressure, temperature, CO2 and solution flow rates, nozzle diameter and initial concentration of the solution...
January 10, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28079006/a-new-vaccine-delivery-vehicle-and-adjuvant-candidate-bordetella-pertussis-inactivated-whole-cells-entrapped-in-alginate-microspheres
#18
Naser Mohammadpour Dounighi, Fereshteh Shahcheraghi, Mehdi Razzaghi-Abyaneh, Mojtaba Nofeli, Hossein Zolfagharian
There is no doubt about whole cell pertussis vaccine efficacy, but it is necessary to improve the vaccine quality specially to decreasing its toxicity by obtaining good immunogenicity with low bacteria number content. In this work, under optimum condition inactivated B. pertussis bacteria cells entrapped alginate microparticles were fabricated and in vivo immunogenicity and potency of new microparticle based vaccine evaluated in mice. Microspheres loaded inactive B. pertussis bacterium cells were prepared via an emulsification method and analyzed for morphology, size, polydispersity index, loading efficiency, loading capacity, release profile and in vivo potency...
January 12, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28075558/immunological-principles-guiding-the-rational-design-of-particles-for-vaccine-delivery
#19
Katelyn T Gause, Adam K Wheatley, Jiwei Cui, Yan Yan, Stephen J Kent, Frank Caruso
Despite the immense public health successes of immunization over the past century, effective vaccines are still lacking for globally important pathogens such as human immunodeficiency virus, malaria, and tuberculosis. Exciting recent advances in immunology and biotechnology over the past few decades have facilitated a shift from empirical to rational vaccine design, opening possibilities for improved vaccines. Some of the most important advancements include (i) the purification of subunit antigens with high safety profiles, (ii) the identification of innate pattern recognition receptors (PRRs) and cognate agonists responsible for inducing immune responses, and (iii) developments in nano- and microparticle fabrication and characterization techniques...
January 11, 2017: ACS Nano
https://www.readbyqxmd.com/read/28071713/sinonasal-delivery-of-resveratrol-via-mucoadhesive-nanostructured-microparticles-in-a-nasal-polyp-mouse-model
#20
Mingyu Lee, Chun Gwon Park, Beom Kang Huh, Se-Na Kim, Seung Ho Lee, Roza Khalmuratova, Jong-Wan Park, Hyun-Woo Shin, Young Bin Choy
Resveratrol (RSV) has been shown to effectively suppress chronic rhinosinusitis with nasal polyps in a mouse model; however, when locally administered to the sinonasal cavity, bolus RSV is limited by low drug bioavailability owing to its low aqueous solubility and relatively rapid clearance from the administration site. To address this limitation, we propose mucoadhesive nanostructured microparticles (PLGA/PEG NM) as a potential carrier for the sinonasal delivery of RSV. In this study, PLGA/PEG NM released RSV in a sustained manner...
January 10, 2017: Scientific Reports
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