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https://www.readbyqxmd.com/read/29782686/promotion-and-inhibition-of-synchronous-glycolytic-oscillations-in-yeast-by-chitosan
#1
Kenichi Shibata, Takashi Amemiya, Yu Kawakita, Kohei Obase, Kiminori Itoh, Masahiro Takinoue, Satoshi Nakata, Tomohiko Yamaguchi
Synchronous rhythmic activities play crucial roles in diverse biological systems. Glycolytic oscillations in yeast cells have been studied for 50 years with the aim of elucidating the mechanisms underlying the intracellular oscillations and their synchronization. We investigated the effects of chemical disturbances on the individual and collective glycolytic oscillations in yeast cells encapsulated in alginate microparticles, and demonstrated that the addition of chitosan, an antimicrobial agent, decreased the duration of these oscillations...
May 21, 2018: FEBS Journal
https://www.readbyqxmd.com/read/29782675/hierarchical-micro-nanostructures-from-human-hair-for-biomedical-applications
#2
Di-Wei Zheng, Sheng Hong, Lu Xu, Chu-Xin Li, Ke Li, Si-Xue Cheng, Xian-Zheng Zhang
With the prominent progress of biomedical engineering, materials with high biocompatibility and versatile functions are urgently needed. So far, hierarchical structures in nature have shed some light on the design of high performance materials both in concept and implementation. Inspired by these, the hierarchical micro-/nanostructures of human hair are explored and human hair is further broken into hierarchical microparticles (HMP) and hierarchical nanoparticles (HNP) with top-down procedures. Compared with commercialized carriers, such as liposomes or albumin nanoparticles, the obtained particles exhibit high hemocompatibility and negligible immunogenicity...
May 21, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29782226/microparticle-release-from-cell-lines-and-its-anti-influenza-activity
#3
Saharat Jantaratrirat, Chompunuch Boonarkart, Kanyarat Ruangrung, Ornpreya Suptawiwat, Prasert Auewarakul
Microparticles (MPs) are vesicles that are released by budding from plasma membrane of living cells. Recently, the role of MPs in antiviral activity has been proposed. We investigated quantity and anti-influenza activity of MPs from human alveolar epithelial cells A549, human bronchial epithelial cells BEAS-2B, human colon adenocarcinoma cells HT-29, and the human lung fibroblast cells MRC-5. MPs were found from all four cell lines. However, anti-influenza activity against an H1N1 influenza virus was found only from MPs of A549 and BEAS-2B...
May 21, 2018: Viral Immunology
https://www.readbyqxmd.com/read/29782160/novel-method-of-quantifying-radioactive-cesium-rich-microparticles-csmps-in-the-environment-from-the-fukushima-daiichi-nuclear-power-plant
#4
Ryohei Ikehara, Mizuki Suetake, Tatsuki Komiya, Genki Furuki, Asumi Ochiai, Shinya Yamasaki, William R Bower, Gareth T W Law, Toshihiko Ohnuki, Bernd Grambow, Rodney C Ewing, Satoshi Utsunomiya
Highly radioactive cesium-rich microparticles (CsMPs) were released from the Fukushima Daiichi nuclear power plant (FDNPP) to the surrounding environment at an early stage of the nuclear disaster in March of 2011; however, the quantity of released CsMPs remains undetermined. Here, we report a novel method to quantify the number of CsMPs in surface soils at or around Fukushima and the fraction of radioactivity they contribute, which we call "quantification of CsMPs" (QCP) and is based on autoradiography...
May 21, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29781012/microfluidic-curved-channel-centrifuge-for-solution-exchange-of-target-microparticles-and-their-simultaneous-separation-from-bacteria
#5
Pouriya Bayat, Pouya Rezai
One of the common operations in sample preparation is to separate specific particles (e.g. target cells, embryos or microparticles) from non-target substances (e.g. bacteria) in a fluid and to wash them into clean buffers for further processing like detection (called solution exchange in this paper). For instance, solution exchange is widely needed in preparing fluidic samples for biosensing at the point-of-care and point-of-use, but still conducted via the use of cumbersome and time-consuming off-chip analyte washing and purification techniques...
May 21, 2018: Soft Matter
https://www.readbyqxmd.com/read/29780989/a-long-chain-protic-ionic-liquid-inside-silica-nanopores-enhanced-proton-mobility-due-to-efficient-self-assembly-and-decoupled-proton-transport
#6
Mounesha N Garaga, Vassilios Dracopoulos, Ulrike Werner-Zwanziger, Josef W Zwanziger, Manuel Maréchal, Michael Persson, Lars Nordstierna, Anna Martinelli
We report enhanced protonic and ionic dynamics in an imidazole/protic ionic liquid mixture confined within the nanopores of silica particles. The ionic liquid is 1-octylimidazolium bis(trifluoromethanesulfonyl)imide ([HC8Im][TFSI]), while the silica particles are microsized and characterized by internal well connected nanopores. We demonstrate that the addition of imidazole is crucial to promote a proton motion decoupled from molecular diffusion, which occurs due to the establishment of new N-HN hydrogen bonds and fast proton exchange events in the ionic domains, as evidenced by both infrared and 1H NMR spectroscopy...
May 21, 2018: Nanoscale
https://www.readbyqxmd.com/read/29780505/macrophage-mediated-delivery-of-light-activated-nitric-oxide-prodrugs-with-spatial-temporal-and-concentration-control
#7
Michael A Evans, Po-Ju Huang, Yuji Iwamoto, Kelly N Ibsen, Emory M Chan, Yutaka Hitomi, Peter C Ford, Samir Mitragotri
Nitric oxide (NO) holds great promise as a treatment for cancer hypoxia, if its concentration and localization can be precisely controlled. Here, we report a "Trojan Horse" strategy to provide the necessary spatial, temporal, and dosage control of such drug-delivery therapies at targeted tissues. Described is a unique package consisting of (1) a manganese-nitrosyl complex, which is a photoactivated NO-releasing moiety (photoNORM), plus Nd3+ -doped upconverting nanoparticles (Nd-UCNPs) incorporated into (2) biodegradable polymer microparticles that are taken up by (3) bone-marrow derived murine macrophages...
April 21, 2018: Chemical Science
https://www.readbyqxmd.com/read/29777856/ocular-irritation-and-cyclosporine-a-distribution-in-the-eye-tissues-after-administration-of-solid-lipid-microparticles-in-the-rabbit-model
#8
Eliza Wolska, Małgorzata Sznitowska, Juliusz Chorążewicz, Oliwia Szerkus, Aleksandra Radwańska, Michał J Markuszewski, Roman Kaliszan, Krystyna Raczyńska
The aim of this study was to investigate the in vivo effect of Solid Lipid Microparticles (SLM), proposed for topical ocular administration of cyclosporine, on the rabbit eye. SLM carrier is an aqueous dispersion of lipid microparticles (20% w/w) with a size up to 15 μm. Cyclosporine was dissolved in the formulation in the concentration of 0.5 or 2.0% (w/w). Ocular tolerance of microsphere dispersion was assessed in rabbit model by the Draize eye test (SLM was compared with emulsion and oily solution), and cyclosporine distribution in ocular tissues was evaluated after multiple application of tested formulations (SLM dispersions, emulsions and oily solution) for 7 days...
May 16, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29777675/brain-derived-microparticles-activate-microglia-macrophages-and-induce-neuroinflammation
#9
Hongtao Rong, Yueshan Fan, Mengchen Yang, Baoliang Zhang, Dongdong Sun, Zilong Zhao, Dong Wang, Weidong Fan, Jianhao Wang, Gang Gu, Fanjian Li, Xilei Liu, Chenxu Rao, Huijiao Chen, Yi Wang, Ye Tian, Jianning Zhang
Microparticles are cell fragments derived from damaged cells that are able to present an antigen from the parent cells to other cells to activate intracellular signaling pathways. Microparticles are closely related to the inflammatory response. Brain-derived microparticles (BDMPs) play an important role in brain injury. However, the inflammatory effect of BDMPs on microglia/macrophages remains unclear. The BDMPs were consumed by microglia/macrophages in vivo and in vitro. The BDMPs activated microglia/macrophages and changed their morphology in vitro...
May 16, 2018: Brain Research
https://www.readbyqxmd.com/read/29776110/n-sma-smc-phase-transitions-probed-by-a-pair-of-elastically-bound-colloids
#10
Muhammed Rasi M, K P Zuhail, Arun Roy, Surajit Dhara
The competing effect of surface anchoring of dispersed microparticles and elasticity of nematic and cholesteric liquid crystals has been shown to stabilize a variety of topological defects. Here we study a pair of colloidal microparticles with homeotropic and planar surface anchoring across N-SmA-SmC phase transitions. We show that below the SmA-SmC phase transition the temperature dependence of interparticle separation (D) of colloids with homeotropic anchoring shows a power-law behavior; D∼(1-T/T_{AC})^{α}, with an exponent α≈0...
March 2018: Physical Review. E
https://www.readbyqxmd.com/read/29774969/combined-effect-of-parathyroid-hormone-and-strontium-ranelate-on-bone-healing-in-ovariectomized-rats
#11
Funda Göker, Selim Ersanlı, Volkan Arısan, Erdal Cevher, Emine Elif Güzel, Halim İşsever, Beyhan Ömer, Gülay Durmuş Altun, Deniz Morina, Tuğba Ekiz Yılmaz, Elmire Dervişoğlu, Massimo Del Fabbro
OBJECTIVE: Parathyroid hormone (PTH) enhances bone healing. Strontium ranelate (SR) is an antiresorptive agent that increases bone formation. Reports about combined effects of PTH and SR on local bone regeneration in osteoporotic subjects are limited. We aimed at investigating the efficacy of PTH and SR for promoting new bone formation in critical sized defects of ovariectomized rats. MATERIALS AND METHODS: PTH- and/or SR-containing poloxamer implant tablets with/without chitosan microparticles were delivered locally to calvarial defects of 90 Wistar rats...
May 18, 2018: Oral Diseases
https://www.readbyqxmd.com/read/29774082/hierarchical-shape-by-shape-assembly-of-microparticles-for-micrometer-scale-viral-delivery-of-two-different-genes
#12
Daewon Lee, Amos Chungwon Lee, Sangkwon Han, Hyung Jong Bae, Seo Woo Song, Yunjin Jeong, Dong Yoon Oh, Seongkyu Cho, Junhoi Kim, Wook Park, Sunghoon Kwon
Understanding tissue engineering using a bottom-up approach has been hindered by technical limitations because no platform can demonstrate the controlled formation of a heterogeneous population of cells in microscale. Here, we demonstrate hierarchical shape-by-shape assembly of virus-laden particles into larger ones to transfect two different genes on the seeded cells. We show that smaller daughter particles with different sizes and shapes can be assembled into the matching indentations of larger parent particles with different sizes and shapes...
May 2018: Biomicrofluidics
https://www.readbyqxmd.com/read/29773369/cellulose-based-molecularly-imprinted-red-blood-cell-like-microparticles-for-the-selective-capture-of-cortisol
#13
Koichiro Hayashi, Hikaru Hayashi, Shota Yamada, Wataru Sakamoto, Toshinobu Yogo
Magnetite-nanoparticle-containing red-blood-cell-like-microparticles (M-RBC-MPs) with a selective ability for trapping cortisol (COR) were synthesized by an electrospray technique of a molecularly imprinted ethyl(hydroxyethyl) cellulose (EHEC)-based precursor. The as-synthezied M-RBC-MPs were ∼3-μm-disks with a dent. M-RBC-MPs contained magnetite nanoparticles below 15 nm in diameter, which exhibited magnetization and no room-temperature coercivity. The molecularly imprinted M-RBC-MPs (MI-M-RBC-MPs) passed through pores less than their diameter...
August 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29773365/a-synbiotic-multiparticulate-microcapsule-for-enhancing-inulin-intestinal-release-and-bifidobacterium-gastro-intestinal-survivability
#14
Bahgat Fayed, Amira Abood, Hoda S El-Sayed, Amal M Hashem, Nayra S H Mehanna
A novel synbiotic multiparticulate microparticle was produced in the current study to expand the synbiotic industrial applications. Initially, the inulin was fabricated into PLGA nanoparticles. After the inulin entrapment efficiency was boosted to reach 92.9 ± 8.4% by adjusting the formulation parameters, the developed particles were characterized by different techniques such as particle size analyzer, TEM, and TLC. The obtained data showed that the particle size was 115.8 ± 82.7 nm, the particles had smooth surface and round shape, and the fabrication procedure did not affect the integrity of the inulin...
August 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29771107/design-and-synthesis-of-a-biocompatible-1d-coordination-polymer-as-anti-breast-cancer-drug-carrier-5-fu-in-vitro-and-in-vivo-studies
#15
Mahsa Rezaei, Alireza Abbasi, Rassoul Dinarvand, Mahmood Jeddi-Tehrani, Jan Janczak
Designable coordination polymers with suitable chemical diversities and biocompatible structures have been proposed as a promising class of vehicles for drug delivery systems. Here, we hydrothermally synthesized a novel one-dimensional (1D) coordination polymer, [Zn(H2 O)6 K2 (H2 BTC)2 (H2 O)4 ](H2 BTC)2 ·2H2 O, where H3 BTC = benzene-1,3,5-tricarboxylic acid (trimesic acid), cp.1. As the hydrogen bonds stabilized 1D chains in three dimensions, the cp.1 could be a good candidate for delivering small-molecule chemotherapeutics such as 5-fluorouracil (5-Fu)...
May 17, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29770568/injection-of-synthetic-mesenchymal-stem-cell-mitigates-osteoporosis-in-rats-after-ovariectomy
#16
Miaoda Shen, Ronghuan Wu, Rilong Jin, Jun Pan, Fang Guo, Zhuoyang Li, Xiangjin Lin, Sanzhong Xu
Osteoporosis is a severe skeletal disorder. Patients have a low bone mineral density and bone structural deterioration. Mounting lines of evidence suggest that inappropriate apoptosis of osteoblasts/osteocytes leads to maladaptive bone remodelling in osteoporosis. It has been suggested that transplantation of stem cells, including mesenchymal stem cells, may alter the trajectory of bone remoulding and mitigate osteoporosis in animal models. However, stem cells needed to be carefully stored and characterized before usage...
May 16, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29770514/influence-of-heat-treatment-on-loading-of-polymeric-multilayer-microcapsules-with-rhodamine-b
#17
Alexey V Ermakov, Olga A Inozemtseva, Dmitry A Gorin, Gleb B Sukhorukov, Sergei Belyakov, Maria N Antipina
Layer-by-layer assembled polymeric multilayer capsules (PMC) of micrometer sizes are permeable for molecules below 1 KDa; therefore, the efficacy of such capsules in the delivery of low molecular weight water soluble bioactive compounds and drugs is frequently challenged. Thermally induced contraction of hollow PMC is explored here to enhance their loading efficacy with model compound, fluorescent rhodamine B (RhB). Four bilayered capsules obtained of poly(diallyldimethylammonium chloride)/polystyrene sulfonate ([PDADMAC/PSS]4 ) or poly-l-arginine/dextran sulfate ([PARG/DS]4 ) on sacrificial CaCO3 spherical microparticles are postloaded with RhB at ambient or elevated temperatures...
May 16, 2018: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/29768002/synergistic-enhancement-of-enzyme-performance-and-resilience-via-orthogonal-peptide-protein-chemistry-enabled-multilayer-construction
#18
Xue-Jian Zhang, Xiao-Wei Wang, Jiaxing Sun, Chao Su, Shuguang Yang, Wen-Bin Zhang
Protein immobilization is critical to utilize their unique functions in diverse applications. Herein, we report that orthogonal peptide-protein chemistry enabled multilayer construction can facilitate the incorporation of various folded structural domains, including calmodulin in different states, affibody and dihydrofolate reductase (DHFR). An extended conformation is found to be the most advantageous for steady film growth. The resulting protein thin films exhibit sensitive and selective responsive behaviors to bio-signals (Ca2+, TFP, NADPH, etc...
May 16, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29767993/multi-metallic-microparticles-increase-the-potency-of-rifampicin-against-intracellular-mycobacterium-tuberculosis
#19
Timothy Ellis, Michele Chiappi, Andres Garcia-Trenco, Maryam Al-Ejji, Srijata Sarkar, Theoni K Georgiou, Milo Sebastian Peter Shaffer, Teresa D Tetley, Stephan Schwander, Mary P Ryan, Alexandra E Porter
Mycobacterium tuberculosis (M.tb) has the extraordinary ability to adapt to the administration of antibiotics through the development of resistance mechanisms. By rapidly exporting drugs from within the cytosol, these pathogenic bacteria diminish antibiotic potency and drive the presentation of drug tolerant tuberculosis (TB). The membrane integrity of M.tb is pivotal in retaining these drug-resistant traits. Silver (Ag) and zinc oxide (ZnO) nanoparticles (NPs) are established antimicrobial agents that effectively compromise membrane stability, giving rise to increased bacterial permeability to antibiotics...
May 16, 2018: ACS Nano
https://www.readbyqxmd.com/read/29765412/neural-stem-cell-conditioned-medium-ameliorated-cerebral-ischemia-reperfusion-injury-in-rats
#20
HongNa Yang, Cuilan Wang, Hui Chen, Lan Li, Shuang Ma, Hao Wang, YaRu Fu, Tingyu Qu
Introduction: Our previous study suggested that NSC-CM (neural stem cell-conditioned medium) inhibited cell apoptosis in vitro . In addition, many studies have shown that neurotrophic factors and microparticles secreted into a conditioned medium by NSCs had neuroprotective effects. Thus, we hypothesized that NSC-CM had the capacity of protecting against cerebral I/R injury. Methods: Adult male Sprague-Dawley rats receiving middle cerebral artery occlusion surgery as an animal model of cerebral I/R injury were randomly assigned to two groups: the control group and NSC-CM-treated group...
2018: Stem Cells International
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