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https://www.readbyqxmd.com/read/29352120/light-induced-assembly-and-self-sorting-of-silica-microparticles
#1
Neus Vilanova, Isja de Feijter, Abraham J P Teunissen, Ilja K Voets
To tailor the properties of colloidal materials, precise control over the self-assembly of their constituents is a prerequisite. Here, we govern the assembly of silica particles by functionalization with supramolecular moieties which interact with each other via directional and reversible hydrogen bonding. Through a generally applicable synthesis protocol, two different types of self-complementary hydrogen bonding moieties, BTA- and UPy-derivatives, are anchored to silica particles. Their self-assembly is initiated by the UV-induced removal of a photolabile protecting group, allowing the formation of hydrogen bonds between tethered molecules...
January 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29351854/electric-field-induced-charging-of-colloidal-particles-in-a-nonpolar-liquid
#2
Caspar Schreuer, Stijn Vandewiele, Filip Strubbe, Kristiaan Neyts, Filip Beunis
HYPOTHESIS: Colloidal particles in a pure nonpolar solvent are expected to be in a state of dynamic equilibrium where a particle's charge fluctuates around a stable mean value. However, we find that PHSA-coated PMMA microparticles in dodecane gain positive charge over time. We hypothesize that this phenomenon is prompted by the high electric field (∼1 V/µm) that is applied in these measurements. Hence, we expect the reaction rate at which charge builds up on the particle to change when modifying the measurement parameters...
January 11, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29348825/a-novel-anti-cd146-antibody-specifically-targets-cancer-cells-by-internalizing-the-molecule
#3
Marie Nollet, Jimmy Stalin, Anaïs Moyon, Waël Traboulsi, Amel Essaadi, Stéphane Robert, Nausicaa Malissen, Richard Bachelier, Laurent Daniel, Alexandrine Foucault-Bertaud, Caroline Gaudy-Marqueste, Romaric Lacroix, Aurélie S Leroyer, Benjamin Guillet, Nathalie Bardin, Françoise Dignat-George, Marcel Blot-Chabaud
CD146 is an adhesion molecule present on many tumors (melanoma, kidney, pancreas, breast, ...). In addition, it has been shown to be expressed on vascular endothelial and smooth muscle cells. Generating an antibody able to specifically recognize CD146 in cancer cells (designated as tumor CD146), but not in normal cells, would thus be of major interest for targeting tumor CD146 without affecting the vascular system. We thus generated antibodies against the extracellular domain of the molecule produced in cancer cells and selected an antibody that specifically recognizes tumor CD146...
December 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29348558/preparation-of-polyaniline-pbs-core-shell-nano-microcomposite-and-its-application-for-photocatalytic-h2-electrogeneration-from-h2o
#4
Mohamed Rabia, H S H Mohamed, Mohamed Shaban, S Taha
Lead sulfide (PbS) and polyaniline (PANI) nano/microparticles were prepared. Then, PANI/PbS core-shell nano/microcomposites (I, II, and III) were prepared by oxidative polymerization of different aniline concentrations (0.01, 0.03, and 0.05 M), respectively, in the presence of 0.05 M PbS. FT-IR, XRD, SEM, HR-TEM, and UV-Vis analyses were carried out to characterize the samples. From the FT-IR data, there are redshifts in PbS and PANI nano/microparticles bands in comparison with PANI/PbS nano/microcomposites...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29347234/pace-and-patterns-of-magnetic-swimmers-in-a-billiard-pool
#5
Florian J Maier, Markus Sesselmann, Ingo Rehberg, Reinhard Richter
We experimentally investigate magnetic surface swimmers on water. These objects self-assemble from ferromagnetic microparticles and a nonmagnetic disk. They are floating on the liquid surface due to interface tension and move under the influence of a harmonically oscillating homogeneous magnetic field oriented vertically, which is distinguished by its amplitude and frequency. The speed of the surface swimmers strongly depends on these parameters. The functional dependencies between speed and amplitude and between speed and frequency are investigated by independently varying both control parameters...
July 2017: Physical Review. E
https://www.readbyqxmd.com/read/29347052/capacitively-coupled-rf-discharge-with-a-large-amount-of-microparticles-spatiotemporal-emission-pattern-and-microparticle-arrangement
#6
M Y Pustylnik, I L Semenov, E Zähringer, H M Thomas
The effect of micron-sized particles on a low-pressure capacitively coupled rf discharge is studied both experimentally and using numerical simulations. In the laboratory experiments, microparticle clouds occupying a considerable fraction of the discharge volume are supported against gravity with the help of the thermophoretic force. The spatiotemporally resolved optical emission measurements are performed with different arrangements of microparticles. The numerical simulations are carried out on the basis of a one-dimensional hybrid (fluid-kinetic) discharge model describing the interaction between plasma and microparticles in a self-consistent way...
September 2017: Physical Review. E
https://www.readbyqxmd.com/read/29345111/association-between-hepatitis-c-infection-in-thai-patients-with-oral-lichen-planus-a-case-control-study
#7
Trin Manomaivat, Surawut Pongsiriwet, Chatsri Kuansuwan, Wacharaporn Thosaporn, Kathawut Tachasuttirut, Anak Iamaroon
AIM: The aim of the present study was to investigate the prevalence of hepatitis C virus (HCV) infection and evaluate liver enzyme levels in patients from upper northern Thailand with oral lichen planus (OLP). METHODS: A case-control study of 101 patients with OLP and 101 patients without OLP was conducted. Peripheral blood was taken from each patient and screened for anti-HCV antibody using immunochromatography. Positive samples were further confirmed using chemiluminescent microparticle immunoassay (CMIA) and reverse transcription-polymerase chain reaction...
January 18, 2018: Journal of Investigative and Clinical Dentistry
https://www.readbyqxmd.com/read/29343815/microrna-145-5p-and-microrna-320a-encapsulated-in-endothelial-microparticles-contribute-to-the-progression-of-vasculitis-in-acute-kawasaki-disease
#8
Hideyuki Nakaoka, Keiichi Hirono, Seiji Yamamoto, Ichiro Takasaki, Kei Takahashi, Koshi Kinoshita, Asami Takasaki, Naonori Nishida, Mako Okabe, Wang Ce, Nariaki Miyao, Kazuyoshi Saito, Keijiro Ibuki, Sayaka Ozawa, Yuichi Adachi, Fukiko Ichida
Kawasaki Disease (KD) is an acute inflammatory disease that takes the form of systemic vasculitis. Endothelial microparticles (EMPs) have been recognized as an important transcellular delivery system. We hypothesized whether EMPs are involved in vasculitis in acute KD. Fifty patients with acute KD were enrolled, divided into two subgroups: those with coronary artery lesions (CAL) (n = 5) and those without CAL (NCAL) (n = 45). EMPs were measured using flow cytometry, and microRNA (miR) expression profiling was performed by microRNA array...
January 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29342127/enhancement-in-corneal-permeability-of-dissolved-carteolol-by-its-combination-with-magnesium-hydroxide-nanoparticles
#9
Noriaki Nagai, Sakie Yamaoka, Yuya Fukuoka, Miyu Ishii, Hiroko Otake, Kazutaka Kanai, Norio Okamoto, Yoshikazu Shimomura
We prepared magnesium hydroxide (MH) nanoparticles, and investigated their effect when combined with dissolved carteolol on the bioavailability and intraocular pressure (IOP)-reducing effect of carteolol. The carteolol was solved in saline containing additives (0.5% methylcellulose, 0.001% benzalkonium chloride, 0.5% mannitol; CRT-solution). MH nanoparticles were prepared by a bead mill method with additives. Then carteolol/MH microparticle and carteolol/MH nanoparticle fixed combinations (mCMFC and nCMFC) were prepared by mixing the CRT-solution and MH particles...
January 17, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29341917/a-novel-method-for-the-production-of-core-shell-microparticles-by-inverse-gelation-optimized-with-artificial-intelligent-tools
#10
Rosalia Rodríguez-Dorado, Mariana Landín, Ayça Altai, Paola Russo, Rita P Aquino, Pasquale Del Gaudio
Numerous studies have been focused on hydrophobic compounds encapsulation as oils. In fact, oils can provide numerous health benefits as synergic ingredient combined with other hydrophobic active ingredients. However, stable microparticles for pharmaceutical purposes are difficult to achieve when commonly techniques are used. In this work, sunflower oil was encapsulated in calcium-alginate capsules by prilling technique in co-axial configuration. Core-shell beads were produced by inverse gelation directly at the nozzle using w/o emulsion containing aqueous calcium chloride solution in sunflower oil pumped through the inner nozzle while an aqueous alginate solution, coming out from the annular nozzle, produced the bead shell...
January 13, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29340882/circulating-small-sized-endothelial-microparticles-as-predictors-of-clinical-outcome-after-chemotherapy-for-breast-cancer-an-exploratory-analysis
#11
Elisa García Garre, Ginés Luengo Gil, Silvia Montoro García, Enrique Gonzalez Billalabeitia, Marta Zafra Poves, Elena García Martinez, Vanessa Roldán Schilling, Esther Navarro Manzano, Alejandra Ivars Rubio, Gregory Y H Lip, Francisco Ayala de la Peña
PURPOSE: Therapeutic exploitation of angiogenesis in breast cancer has been limited by the lack of reliable biomarkers. Circulating small-sized endothelial microparticles (sEMP) are likely to play a significant role as messengers of angiogenesis. Higher levels of EMP have been observed in cancer patients, but their prognostic value in breast cancer is unknown. Our aim was to determine the value of circulating sEMP as a marker of response to chemotherapy in breast cancer. METHODS: We included patients with breast cancer treated with neoadjuvant or first-line chemotherapy...
January 16, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29337670/sustained-release-biodegradable-solid-lipid-microparticles-formulation-evaluation-and-statistical-optimization-by-response-surface-methodology
#12
Muhammad Hanif, Hafeez Ullah Khan, Samina Afzal, Asif Mahmood, Safirah Maheen, Khurram Afzal, Nabila Iqbal, Mehwish Andleeb, Nazar Abbas
For preparing nebivolol loaded solid lipid microparticles (SLMs) by the solvent evaporation microencapsulation process from carnauba wax and glyceryl monostearate, central composite design was used to study the impact of independent variables on yield (Y1), entrapment efficiency (Y2) and drug release (Y3). SLMs having a 10-40 μm size range, with good rheological behavior and spherical smooth surfaces, were produced. Fourier transform infrared spectroscopy, differential scanning calorimetry and X-ray diffractometry pointed to compatibility between formulation components and the zeta-potential study confirmed better stability due to the presence of negative charge (-20 to -40 mV)...
December 20, 2017: Acta Pharmaceutica
https://www.readbyqxmd.com/read/29336552/engineering-the-surface-of-therapeutic-living-cells
#13
Jooyeon Park, Brenda Andrade, Yongbeom Seo, Myung-Joo Kim, Steven C Zimmerman, Hyunjoon Kong
Biological cells are complex living machines that have garnered significant attention for their potential to serve as a new generation of therapeutic and delivery agents. Because of their secretion, differentiation, and homing activities, therapeutic cells have tremendous potential to treat or even cure various diseases and injuries that have defied conventional therapeutic strategies. Therapeutic cells can be systemically or locally transplanted. In addition, with their ability to express receptors that bind specific tissue markers, cells are being studied as nano- or microsized drug carriers capable of targeted transport...
January 16, 2018: Chemical Reviews
https://www.readbyqxmd.com/read/29334279/uric-acid-and-the-vaccine-adjuvant-activity-of-aluminum-oxy-hydroxide-nanoparticles
#14
Sachin G Thakkar, Haiyue Xu, Xu Li, Zhengrong Cui
In an effort to improve the adjuvanticity of insoluble aluminum salts, we discovered that the adjuvant activity of aluminum salt nanoparticles is significantly stronger than aluminum salt microparticles, likely related to nanoparticle's stronger ability to directly activate NLRP3 inflammasome as the nanoparticles are more efficiently taken up by phagocytic cells. Endogenous signals such as uric acid from cell damage or death caused by the cytotoxicity of aluminum salts are thought to indirectly activate inflammasome, prompting us to hypothesize that the potent adjuvant activity of aluminum salt nanoparticles is also related to their ability to stimulate uric acid production...
January 15, 2018: Journal of Drug Targeting
https://www.readbyqxmd.com/read/29330877/characterization-of-biologic-response-modifiers-in-the-supernatant-of-conventional-refrigerated-and-cryopreserved-platelets
#15
Lacey Johnson, Shereen Tan, Emily Jenkins, Ben Wood, Denese C Marks
BACKGROUND: Alternatives to room temperature storage of platelets (PLTs) are of interest to support blood banking logistics. The aim of this study was to compare the presence of biologic response modifiers (BRMs) in PLT concentrates stored under conventional room temperature conditions with refrigerated or cryopreserved PLTs. STUDY DESIGN AND METHODS: A three-arm pool-and-split study was carried out using buffy coat-derived PLTs stored in 30% plasma/70% SSP+. The three matched treatment arms were as follows: room temperature (20-24°C), cold (2-6°C), and cryopreserved (-80°C with DMSO)...
January 12, 2018: Transfusion
https://www.readbyqxmd.com/read/29330407/multiscale-and-luminescent-hollow-microspheres-for-gas-phase-thermometry
#16
Lothar Bischoff, Michael Stephan, Christina S Birkel, Christian F Litterscheid, Andreas Dreizler, Barbara Albert
Recently developed laser-based measurement techniques are used to image the temperatures and velocities in gas flows. They require new phosphor materials with an unprecedented combination of properties. A novel synthesis procedure is described here; it results in hierarchically structured, hollow microspheres of Eu3+-doped Y2O3, with unusual particle sizes and very good characteristics compared to full particles. Solution-based precipitation on polymer microballoons produces very stable and luminescent, ceramic materials of extremely low density...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29329679/standardization-of-a-fast-and-effective-method-for-the-generation-and-detection-of-platelet-derived-microparticles-by-a-flow-cytometer
#17
Daniela Recabarren-Leiva, Marcelo Alarcón
The Flow Cytometry is the principal method used to measure platelet-derived microparticles (PDMPs), by fluorescent properties analysis. PDMPs (0.1-1.0 microns) are abundant in circulation, accounting for approximately 90% of the microparticles and are associated with Cardiovascular Disease, the leading cause of death in the world.
January 9, 2018: Immunology Letters
https://www.readbyqxmd.com/read/29329052/efficient-and-cost-effective-generation-of-hepatocyte-like-cells-through-microparticle-mediated-delivery-of-growth-factors-in-a-3d-culture-of-human-pluripotent-stem-cells
#18
Zeinab Heidariyan, Mohammad Hossein Ghanian, Mohsen Ashjari, Zahra Farzaneh, Mostafa Najarasl, Mehran Rezaei Larijani, Abbas Piryaei, Massoud Vosough, Hossein Baharvand
Biomedical application of human pluripotent stem cell-derived hepatocyte-like cells (hPSC-HLCs) relies on efficient large-scale differentiation, which is commonly performed by a suspension culture of three-dimensional (3D) multicellular spheroids in bioreactors. However, this approach requires large amounts of growth factors (GFs) and the need to overcome limited diffusional transport posed by the inherent 3D structure of hPSC spheroids. Here, we have hypothesized that localized delivery of GFs by incorporation of GF-laden degradable polymeric microparticles (MPs) within the hPSC spheroids would circumvent such limitations...
January 2, 2018: Biomaterials
https://www.readbyqxmd.com/read/29328626/polystyrene-core-silica-shell-scintillant-nanoparticles-for-low-energy-radionuclide-quantification-in-aqueous-media
#19
Colleen M Janczak, Isen A C Calderon, Zeinab Mokhtari, Craig Alan Aspinwall
β-particle emitting radionuclides are useful molecular labels due to their abundance in biomolecules. Detection of -emission from 3H, 35S, and 33P, important biological isotopes, is challenging due to the low energies (Emax ≤ 300 keV) and short penetration depths (≤ 0.6 mm) in aqueous media. The activity of biologically relevant β-emitters is usually measured in liquid scintillation cocktail (LSC), a mixture of energy-absorbing organic solvents, surfactants, and scintillant fluorophores, which places significant limitations on the ability to acquire time-resolved measurements directly in aqueous biological systems...
January 12, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29328291/whispering-gallery-modes-in-a-single-silica-microparticle-attached-to-an-optical-microfiber-and-their-application-for-highly-sensitive-displacement-sensing
#20
Ningyu Liu, Lei Shi, Song Zhu, Xinbiao Xu, Shixing Yuan, Xinliang Zhang
A compact and relatively stable structure is experimentally demonstrated to excite whispering gallery modes (WGMs) in a single chemically fabricated silica microparticles with a diameter of around 10.6 μm attached to an optical microfiber. The resonance dip with an extinction ratio of 14 dB and Q factor of around 300 has been achieved. Based on the WGMs in this structure, an in-line fiber-optic displacement sensor is presented with a high sensitivity of 33 dB/mm and a measurement range of over 400 μm. The measurement resolution of this displacement sensor can reach to ~10 μm...
January 8, 2018: Optics Express
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