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Sara Salatin, M Alami-Milani, R Daneshgar, M Jelvehgari
Selegiline hydrochloride (SL) is chosen as an adjunct for the control of clinical signs of Parkinsonian patients. The aim of the present work is to develop and optimize thermosensitive gels using Pluronic (F-127) for enhancing transport of SL into the brain through the nasal route. SL gels were prepared using a cold method and the Box-Behnken experimental design methodology. Drug (SL), gelling agent (F-127) and emulsifier (Propylene glycol, PG) were selected as independent variables while the gelation temperature, gel strength, pH, gel content, and gel erosion were considered as dependent variables...
June 22, 2018: Drug Development and Industrial Pharmacy
Marie Anneberg, Ole Brink
The aim for this review is to present general considerations in relation to malalignment after osteosynthesis with plate fixation and its consequences after fractures in adults in each of the following anatomical locations: humerus, forearm, femur, tibia. Recommendations for accepted malalignment in humerus diaphyseal fracture is varus <20 degrees, valgus <15 degrees, sagittal deformity <5 degrees and rotation <30 degrees. Recommendations when treating fractures of the forearm is anatomical reduction...
June 2018: Injury
Utku Kandemir
With advances in osteosynthesis technology providing improved stability of fixation and better outcomes, surgical treatment has become the standard of care for distal femur fractures. Pre-contoured distal femoral locking plates are the most commonly used implants for fixation. However, healing problems such as delayed union, failure of fixation, and /or nonunion are not uncommon. The fixation construct being "too stiff" is a commonly quoted reason when nonunion/failure of fixation occurs on distal femur fractures fixed with a plate...
June 2018: Injury
Peter Augat, Christian von Rüden
Internal fixation of bone fractures by plate osteosynthesis has continuously evolved for more than 100 years. The aim of internal fracture fixation has always been to restore the functional capacity of the broken bone. The principal requirements of operative fracture management, those being anatomical fracture reduction, durable fixation, preservation of biology, promotion of fracture healing and early patient mobilization, have always been crucial but were accomplished to different extents depending on the focus of the specific fracture fixation principle employed...
June 2018: Injury
Hiwa O Ahmed, Sarmad H Arif, Sabah Abid Abdulhakim, Aram Kakarash, Mohammad Amin Ali Omer, Aree Majid Nuri, Hallo H Omer, Hardi Kareem Jalal, Shahen H Omer, Nashadin Aziz Muhammad
BACKGROUND: The increasing incidence of morbid obesity suggests that the quantity of bariatric surgical procedures will continue to multiply each year, many patients who have experienced massive weight loss are left with the dissatisfying consequences of loose and redundant skin, resulting in contour irregularities, an aesthetic and functional problem, and profound dissatisfaction with appearance, residual body image dissatisfaction, There is a subsequent increase in the number of patients seeking additional corrective procedures including abdominoplasty which considered as one of the most popular body-contouring procedures...
June 18, 2018: International Journal of Surgery
Pierfrancesco Franco, Francesca Arcadipane, Elisabetta Trino, Elena Gallio, Stefania Martini, Giuseppe Carlo Iorio, Cristina Piva, Francesco Moretto, Maria Grazia Ruo Redda, Roberta Verna, Vassiliki Tseroni, Cristina Bona, Gabriele Pozzi, Christian Fiandra, Riccardo Ragona, Oscar Bertetto, Umberto Ricardi
Objective: Delineation of treatment volumes is a major source of uncertainties in radiotherapy (RT). This is also true for rectal cancer patients undergoing neoadjuvant RT, with a potential impact on treatment quality. We investigated the role of the digital platform Anatom-e (Anatom-e Information Sytems Ltd., Houston, Texas) in increasing the compliance to follow a specific treatment protocol in a multicentric setting. Materials and methods: Two clinical cases of locally advanced rectal cancer were chosen...
June 2018: Clinical and Translational Radiation Oncology
Jammula S Srinivas, Prakash Panagatla, Mukunda Reddy Damalacheru
Introduction: Reconstruction of complex abdominal wall defects is both challenging and technically demanding for plastic surgeon. Objectives in abdominal wall reconstruction are consistent and include restoration of abdominal wall integrity, protection of intra abdominal viscera and prevention of herniation. Materials: We conducted a retrospective study on five patients in whom lateral thigh flaps such as anterolateral thigh (ALT) flaps and tensor fascia lata (TFL) myocutaneous flaps as pedicled or free flaps were used for complex abdominal wall Type II defects over a 5- years period between 2007 and 2012...
January 2018: Indian Journal of Plastic Surgery: Official Publication of the Association of Plastic Surgeons of India
Jeffrey H Lee, Leonard B Kaban, Michael J Yaremchuk
BACKGROUND: Le fort I maxillary osteotomies and sagittal split mandibular osteotomies are performed to correct significant dentofacial deformities. The multidimensional skeletal movements, particularly those of large magnitude may result in contour irregularities and facial imbalances. METHODS: Three dimensional images were reconstructed from computed tomographic (CT) scans in patients unhappy with their appearances after Le Fort I advancement and/or bilateral sagittal split osteotomies (BSSO)...
June 14, 2018: Plastic and Reconstructive Surgery
Luísa Fernandes Monken, Luiza Vale Coelho, Matheus Silva Costa, José Alcides Almeida de Arruda, Ricardo Alves Mesquita, Amália Moreno
The ocular prosthesis is a modality of facial prosthesis that acts on the repair of loss or deformity of the ocular globe. Prosthetic rehabilitations destined to anophthalmic cavities that suffered cicatricial retraction represent a challenge during fabrication since they often need to be reduced due to atrophic of the cavity and simultaneously need to have a good esthetic appearance regarding the contour and artificial iris. This clinical report describes the ocular prosthetic rehabilitation of a 77-year-old man with anophthalmic atrophic cavity due to herpes zoster-induced loss...
June 20, 2018: Journal of Craniofacial Surgery
Nina Jendrike, Annette Baumstark, Stefan Pleus, Christina Liebing, Ulrike Kamecke, Cornelia Haug, Guido Freckmann
OBJECTIVE: In this study, accuracy in the hands of intended users was evaluated for five self-monitoring of blood glucose (SMBG) systems based on ISO 15197:2013, and possibly related insulin dosing errors were calculated. In addition, accuracy was assessed in the hands of study personnel Methods: For each system (Accu-Chek® Aviva Connect (A), Contour® Next One (B), FreeStyle Freedom Lite (C), GlucoMen® areo (D), OneTouch® Verio® (E)) one test strip lot was evaluated as required by ISO 15197:2013, clause 8...
June 21, 2018: Current Medical Research and Opinion
Amitpal Singh Saini, Catherine S Hwang, Matthew C Biagioli, Indra J Das
PURPOSE: To compare doses to organs at risk (OARs) for left-sided whole-breast radiation therapy with comparable planning target volume (PTV) coverage using three techniques: free breathing in a supine position (SFB), deep inspirational breath-hold in a supine position (SDIBH), and free breathing in prone position (PFB). MATERIALS AND METHODS: Thirty-three patients with left-sided early-stage breast cancer underwent CT simulation following SFB, SDIBH, and PFB protocols for whole-breast radiation therapy...
June 21, 2018: Journal of Applied Clinical Medical Physics
Jong-Lim Kim, Jin Yong Shin, Si-Gyun Roh, Suk Choo Chang, Nae-Ho Lee
INTRODUCTION: Liposuction is one of the most widely performed aesthetic surgeries. It is mainly used for the correction of deep and superficial fat accumulations and remodeling of the body contour. CASE PRESENTATION: We present a rare case of unusual rubber foreign body found within the periumbilical area during the reconstruction of buried umbilicus after liposuction.A 61-year-old female had undergone a liposuction surgery 10 years ago. Last year, she experienced signs of inflammation around the periumbilical area...
June 2018: Medicine (Baltimore)
Ju-Hyang Lee, Kyung In Woo, Yoon-Duck Kim
PURPOSE: Undercorrected blepharoptosis can be encountered after frontalis sling operation. Revision surgery for undercorrection has commonly involved introducing a new sling material. We describe and evaluate a simple surgical technique to correct undercorrection by adjusting preexisting fascia. METHODS: This is a retrospective interventional case series of patients undergoing sling revision between February 2010 and February 2017. Skin incision was made on the previous incision line...
June 18, 2018: Ophthalmic Plastic and Reconstructive Surgery
Lawrence J Oh, Eugene Wong, Sol Bae, Angelo Tsirbas
Background: Repair of blepharoptosis from the posterior eyelid approach has usually been done utilizing a Müller's muscle-conjuctival resection (MMCR) or an "open sky" technique. We present a new technique to advance the levator muscle from the posterior-approach in a closed fashion that can be used in patients with severe involutional ptosis. Methods: A retrospective chart review was performed for consecutive patients with severe involutional blepharoptosis during a 6-year period treated by a single surgeon with a Closed Posterior Levator Advancement...
May 2018: Plastic and Reconstructive Surgery. Global Open
Chin Siang Ong, Gerard Deib, Pooja Yesantharao, Ye Qiao, Jina Pakpoor, Narutoshi Hibino, Ferdinand Hui, Juan R Garcia
Objectives: Virtual reality (VR) allows users to experience realistic, immersive 3D virtual environments with the depth perception and binocular field of view of real 3D settings. Newer VR technology has now allowed for interaction with 3D objects within these virtual environments through the use of VR controllers. This technical note describes our preliminary experience with VR as an adjunct tool to traditional angiographic imaging in the preprocedural workup of a patient with a complex pseudoaneurysm...
June 2018: Journal of Vascular and Interventional Neurology
Keying Xu, Junwei Shi, Ali Pourmand, Thirupandiyur S Udayakumar, Nesrin Dogan, Weizhao Zhao, Alan Pollack, Yidong Yang
Gold nanoparticles (GNP) have been intensively investigated for applications in cancer imaging and therapy. Most imaging studies focused on microscopic imaging. Their potential as optical imaging probes for whole body small animal imaging has rarely been explored. Taking advantage of their surface plasmon resonance (SPR) properties, we aim to develop a noninvasive diffuse optical imaging method to map the distribution of a special type of GNP, gold nanorods (GNR), in small animals. We developed an integrated dual-modality imaging system capable of both x-ray computed tomography (XCT) and diffuse optical tomography (DOT)...
June 19, 2018: Scientific Reports
Seongwon Cha, Ji Eun Lim, Ah Yeon Park, Jun-Hyeong Do, Si Woo Lee, Chol Shin, Nam Han Cho, Ji-One Kang, Jeong Min Nam, Jong-Sik Kim, Kwang-Man Woo, Seung-Hwan Lee, Jong Yeol Kim, Bermseok Oh
BACKGROUND: Face morphology is strongly determined by genetic factors. However, only a small number of genes related to face morphology have been identified to date. Here, we performed a two-stage genome-wide association study (GWAS) of 85 face morphological traits in 7569 Koreans (5643 in the discovery set and 1926 in the replication set). RESULTS: In this study, we analyzed 85 facial traits, including facial angles. After discovery GWAS, 128 single nucleotide polymorphisms (SNPs) showing an association of P < 5 × 10- 6 were selected to determine the replication of the associations, and meta-analysis of discovery GWAS and the replication analysis resulted in five genome-wide significant loci...
June 19, 2018: BMC Genomics
Irene Caprara, Elsie Premereur, Maria C Romero, Pedro Faria, Peter Janssen
The primate dorsal visual stream processes object shape to guide actions involving an object, but the transmission of shape information beyond posterior parietal cortex remains largely unknown. To clarify the information flow between parietal and frontal cortex, we applied electrical microstimulation during functional Magnetic Resonance Imaging (fMRI) in a shape-selective patch in the posterior part of the Anterior Intraparietal area (pAIP) to chart its connectivity. Subsequently, we recorded single-unit responses to images of objects in the fMRI activation in prefrontal cortex, corresponding to area 45B, elicited by pAIP microstimulation...
June 16, 2018: NeuroImage
David M Whitehead, Paul R Weiss, Dina Podolsky
BACKGROUND: Chest wall recontouring is a common surgical treatment of gender dysphoria in transmen and nonbinary individuals assigned female at birth. This study reviews more than 20 years of cases to identify risk factors for postoperative complications and likelihood of preservation of nipple sensation. METHODS: One hundred thirty-seven cases of female-to-male chest wall recontouring by a single surgeon from 1994 to 2016 were reviewed, 99 of which were included for final analysis...
June 19, 2018: Annals of Plastic Surgery
Bidhu K Mohanti
Since 201 4, there is a shift in terror targets, with a 1 72% increase in the deaths of common citizens. India ranks fourth in the global terrorism index. Intelligence, security and counter-terrorism conjointly form the contours of priority for governance and public engagement but the attendant aspects of health system remain neglected. Recurring acts of global terrorism have given rise to unique medical requirements that can be termed as 'terror medicine', geared towards managing health impacts of terrorism and not just a single patient...
September 2017: National Medical Journal of India
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