Jacek Staszewski, Adam Stȩpień, Renata Piusińska-Macoch, Aleksander Dȩbiec, Katarzyna Gniadek-Olejniczak, Emilia Frankowska, Artur Maliborski, Zoltan Chadaide, David Balo, Beata Król, Rafael Namias, George Harston, Józef Mróz, Piotr Piasecki
This study is designed to determine the efficacy of Cerebrolysin treatment as an add-on therapy to mechanical thrombectomy (MT) in reducing global disability in subjects with acute ischemic stroke (AIS). We have planned a single center, prospective, open-label, single-arm study with a 12-month follow-up of 50 patients with moderate to severe AIS, with a small established infarct core and with good collateral circulation who achieve significant reperfusion following MT and who receive additional Cerebrolysin within 8 h of stroke onset compared to 50 historical controls treated with MT alone, matched for age, clinical severity, occlusion location, baseline perfusion lesion volume, onset to reperfusion time, and use of iv thrombolytic therapy...
2022: Frontiers in Neurology